3TDU

n-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex: structure of a human cul1whb- dcn1p-acetylated ubc12n complex

• Total interactions analyzed: 15
• Total true interactions: 7
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 60
  • Norm. En. per Res.: -4.3868
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-28.4626	-1.6499	-100.169	-130.2815	82	7	0	4601	3	43	52
A-C	-52.5706	-57.2041	-155.474	-265.2486	64	11	0	5854	5	50	26
A-D	-11.2006	7.0006	-46.4991	-50.6992	29	3	0	1672	0	19	13
A-F	-34.2397	-17.0584	-103.926	-155.2241	55	5	6	4803	1	15	7
B-C	0.0	4.0359	-24.8105	-20.7746	26	0	0	1441	1	17	16
B-D	-60.6727	-55.627	-146.906	-263.2057	60	9	0	5818	4	50	27
B-E	-20.8691	-16.5285	-111.253	-148.6506	57	6	6	4778	1	15	4

Interface residues

• A-B: ALA106A, ALA111A, ALA111B, ALA112A, ALA112B, ARG110A, ARG110B, ARG153A, ARG153B, ARG62A, ARG62B, ASN163A, ASN163B, ASN214A, ASN214B, ASN79A, ASN79B, ASP124A, ASP124B, ASP156A, ASP156B, GLN120A, GLN120B, GLN159A, GLN159B, GLU121A, GLU121B, GLU128A, GLU128B, GLU147A, GLU147B, GLU150A, GLU66A, GLU66B, GLY125A, GLY125B, GLY130A, GLY130B, GLY169A, GLY60A, GLY60B, ILE105A, LEU129A, LEU129B, LYS108A, LYS108B, LYS119A, LYS119B, LYS143A, LYS143B, LYS155A, LYS155B, LYS166A, LYS166B, LYS171A, LYS171B, LYS210A, LYS210B, LYS63A, LYS63B, LYS80A, MET123A, MET123B, MET126A, MET126B, PHE109A, PHE109B, PHE117A, PHE117B, PHE122A, PHE122B, PHE160A, PHE160B, PRO168B, SER118A, SER118B, SER61A, SER61B, THR127A, THR127B, TRP107A, TRP107B
• A-C: ALA235A, ARG745C, ARG764C, ASN214A, ASP211A, ASP218A, ASP231A, ASP241A, ASP242A, ASP754C, ASP766C, ASP770C, CYS752C, GLN159A, GLN728C, GLU232A, GLU233A, GLU245A, GLU758C, GLU760C, GLU763C, GLU768C, GLY172A, GLY234A, GLY767C, HIS727C, ILE208A, ILE240A, ILE749C, ILE753C, ILE755C, ILE757C, LEU215A, LEU217A, LEU239A, LEU731C, LEU762C, LYS155A, LYS171A, LYS205A, LYS210A, LYS726C, LYS750C, LYS751C, LYS759C, LYS769C, MET222A, PHE162A, PHE219A, PRO209A, PRO237A, PRO747C, SER207A, THR212A, THR221A, THR771C, TRP236A, TYR230A, TYR761C, TYR772C, VAL238A, VAL746C, VAL748C, VAL765C
• A-D: ALA776D, ARG62A, ARG764D, ASP132A, ASP766D, GLN140A, GLN67A, GLU66A, GLU758D, GLU760D, GLU763D, GLY130A, GLY60A, ILE755D, ILE757D, LEU65A, LEU756D, LEU762D, LEU775D, LYS136A, LYS63A, LYS64A, LYS759D, SER133A, SER61A, SER773D, TYR761D, TYR774D, VAL765D
• A-F: ALA165A, ALA178A, ALA180A, ALA98A, ASN167A, ASN183A, ASP174A, ASP74A, ASP84A, ASP91A, ASP96A, CYS115A, CYS90A, GLN10F, GLN114A, GLN76A, GLN87A, GLN88A, GLN9F, GLU116A, GLU14F, GLU15F, GLU176A, GLY82A, GLY85A, ILE100A, ILE179A, ILE2F, ILE81A, ILE83A, ILE86A, LEU103A, LEU173A, LEU184A, LEU4F, LEU7F, LYS11F, LYS12F, LYS166A, LYS3F, LYS8F, MET177A, PHE164A, PHE5F, PHE89A, PRO168A, PRO75A, PRO97A, SER6F, SER99A, THR113A, THR161A, TRP182A, TYR181A, VAL102A
• B-C: ALA776C, ARG62B, ARG764C, ASP132B, ASP766C, CYS131B, GLN140B, GLN67B, GLU760C, GLU763C, GLY130B, GLY60B, GLY767C, LEU129B, LEU65B, LEU762C, LEU775C, LYS136B, LYS63B, LYS64B, LYS759C, SER61B, SER773C, TYR761C, TYR774C, VAL765C
• B-D: ALA235B, ARG745D, ARG764D, ASN214B, ASN229B, ASP211B, ASP218B, ASP231B, ASP241B, ASP242B, ASP754D, ASP766D, ASP770D, CYS752D, GLN159B, GLN728D, GLU232B, GLU233B, GLU245B, GLU758D, GLU760D, GLU763D, GLU768D, GLY172B, GLY234B, GLY767D, HIS727D, ILE208B, ILE240B, ILE749D, ILE753D, ILE755D, ILE757D, LEU215B, LEU239B, LEU730D, LEU731D, LYS155B, LYS171B, LYS210B, LYS726D, LYS750D, LYS751D, LYS759D, LYS769D, MET222B, PHE219B, PRO209B, PRO237B, PRO747D, SER207B, THR212B, THR771D, TRP236B, TYR230B, TYR772D, VAL238B, VAL746D, VAL748D, VAL765D
• B-E: ALA165B, ALA178B, ALA180B, ALA98B, ASN167B, ASN183B, ASP174B, ASP74B, ASP84B, ASP91B, ASP96B, CYS115B, CYS90B, GLN10E, GLN114B, GLN170B, GLN76B, GLN87B, GLN88B, GLN9E, GLU116B, GLU15E, GLU176B, GLY82B, GLY85B, ILE100B, ILE179B, ILE2E, ILE81B, ILE83B, ILE86B, LEU103B, LEU173B, LEU184B, LEU4E, LEU7E, LYS11E, LYS12E, LYS166B, LYS3E, LYS80B, LYS8E, MET177B, PHE164B, PHE5E, PHE89B, PRO168B, PRO75B, PRO97B, SER6E, SER99B, THR113B, THR161B, TRP182B, TYR181B, VAL102B, VAL185B