3TDK

crystal structure of human udp-glucose dehydrogenase

• Total interactions analyzed: 66
• Total true interactions: 22
• Strongest Interaction:
  • Chains: D-C
  • Int. Res.: 211
  • Norm. En. per Res.: -3.719
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-42.4452	-48.252	-702.169	-792.8662	214	15	39	29839	3	41	47
A-F	0.0	0.0	-11.5964	-11.5964	10	3	0	248	0	0	0
A-E	-60.5581	-37.1303	-170.333	-268.0213	80	9	1	6658	4	19	24
A-C	-54.0939	-34.0626	-164.963	-253.1194	76	14	1	6603	4	20	24
B-F	-61.5463	-36.9703	-173.168	-271.6846	76	14	1	6686	4	19	24
B-D	-57.2215	-35.8743	-174.538	-267.6338	79	13	1	6702	3	19	24
B-C	0.0	0.0	-10.7728	-10.7728	10	0	0	217	0	0	0
G-H	-29.593	-52.5333	-705.842	-787.9683	215	22	39	30023	2	39	47
G-L	0.0	0.0	-0.835	-0.835	10	3	0	246	0	0	0
G-K	-67.0495	-34.3916	-172.355	-273.7961	78	14	1	6630	3	19	25
G-I	-46.6095	-34.2147	-163.956	-244.7801	78	14	1	6453	3	20	25
H-L	-51.6698	-34.6247	-102.041	-188.3354	80	13	1	6654	4	20	24
H-J	-46.9515	-34.4085	-152.974	-234.334	76	7	1	6218	4	19	24
H-I	0.0	0.0	-11.3026	-11.3026	9	0	0	227	0	0	0
L-K	-18.7494	-47.3667	-687.291	-753.4071	211	18	39	29644	3	43	47
L-D	-13.2336	2.6558	-57.8569	-68.4346	40	0	0	2484	2	15	17
K-C	0.0	1.2872	-37.4711	-36.1839	34	0	0	1907	2	10	14
F-E	-28.753	-46.8964	-703.36	-779.0094	213	16	38	30169	2	40	47
F-J	-12.3048	3.6524	-59.2133	-67.8657	41	1	0	2459	2	15	17
E-I	-3.4268	2.4198	-36.0047	-37.0117	35	1	0	1854	2	11	13
D-C	-36.4763	-49.4453	-698.796	-784.7176	211	20	40	29813	3	38	47
J-I	-45.6217	-50.3778	-682.612	-778.6115	215	23	40	29737	2	38	47

Interface residues

• A-B: ALA164A, ALA164B, ALA222A, ALA222B, ALA223A, ALA223B, ALA225A, ALA225B, ALA228A, ALA228B, ALA239A, ALA239B, ALA243A, ALA243B, ALA246A, ALA246B, ALA252A, ALA252B, ALA254A, ALA254B, ALA297A, ALA297B, ARG135A, ARG135B, ARG177A, ARG177B, ARG205A, ARG205B, ARG230A, ARG230B, ARG260A, ARG260B, ARG298A, ARG298B, ARG312A, ARG312B, ARG313A, ARG313B, ASN174A, ASN174B, ASN212A, ASN212B, ASN224A, ASN224B, ASN235A, ASN235B, ASN263A, ASN263B, ASN283A, ASN283B, ASN292A, ASN292B, ASN307A, ASN307B, ASP171A, ASP171B, ASP176A, ASP176B, ASP247A, ASP247B, ASP258A, ASP258B, ASP305A, ASP305B, ASP308A, ASP308B, CYS241A, CYS241B, CYS288A, CYS288B, GLN229A, GLN229B, GLN259A, GLN259B, GLN301A, GLN301B, GLN302A, GLN302B, GLN310A, GLN310B, GLU165A, GLU165B, GLU184A, GLU184B, GLU206A, GLU206B, GLU217A, GLU217B, GLU242A, GLU242B, GLU250A, GLU250B, GLU289A, GLU289B, GLU295A, GLU295B, GLY245A, GLY245B, GLY256A, GLY256B, GLY262A, GLY262B, ILE208A, ILE208B, ILE231A, ILE231B, ILE234A, ILE234B, ILE237A, ILE237B, ILE255A, ILE255B, ILE261A, ILE261B, ILE304A, ILE304B, LEU163A, LEU163B, LEU179A, LEU179B, LEU209A, LEU209B, LEU218A, LEU218B, LEU221A, LEU221B, LEU227A, LEU227B, LEU240A, LEU240B, LEU266A, LEU266B, LEU284A, LEU284B, LEU287A, LEU287B, LEU291A, LEU291B, LEU293A, LEU293B, LYS207A, LYS207B, LYS220A, LYS220B, LYS264A, LYS264B, LYS339A, LYS339B, LYS465A, MET257A, MET257B, MET306A, MET306B, PHE162A, PHE162B, PHE226A, PHE226B, PHE265A, PHE265B, PHE272A, PHE272B, PHE277A, PHE277B, PRO160A, PRO160B, PRO175A, PRO175B, PRO204A, PRO294A, PRO294B, SER215A, SER215B, SER216A, SER216B, SER219A, SER219B, SER232A, SER232B, SER233A, SER233B, SER236A, SER236B, SER238A, SER238B, THR167A, THR167B, THR210A, THR210B, THR211A, THR211B, THR244A, THR244B, THR253A, THR253B, TRP214A, TRP214B, TRP300A, TRP300B, TYR299A, TYR299B, TYR309A, TYR309B, VAL178A, VAL178B, VAL248A, VAL248B, VAL251A, VAL251B, VAL285A, VAL285B, VAL296A, VAL296B, VAL303A, VAL303B
• A-F: ALA290A, ALA290F, ASN292A, ASN292F, LEU291A, LEU291F, LEU293A, LEU293F, PRO294A, PRO294F
• A-E: ALA103A, ALA104A, ALA111A, ALA113A, ALA136A, ALA146A, ALA290A, ALA315E, ALA362E, ALA408E, ALA436E, ARG102A, ARG114A, ARG135A, ARG141A, ARG142A, ARG312E, ARG313E, ARG317E, ARG393E, ASN147A, ASN283A, ASN324E, ASP105A, ASP145A, ASP320E, ASP328E, ASP359E, GLN118A, GLN390E, GLN458E, GLU110A, GLU138A, GLU360E, GLU460E, GLY361E, GLY456E, GLY97A, GLY99A, HIS409E, HIS429E, ILE109A, ILE140A, ILE143A, ILE319E, LEU106A, LEU322E, LEU357E, LEU394E, LEU433E, LYS100A, LYS107A, LYS329E, LYS434E, LYS94A, MET358E, MET432E, MET98A, PHE144A, PHE323E, PHE437E, PHE439E, PRO435E, PRO92A, SER139A, SER316E, SER321E, THR148A, THR325E, THR327E, THR91A, THR95A, TYR108A, TYR286A, TYR356E, TYR96A, VAL117A, VAL134A, VAL326E, VAL466E
• A-C: ALA103C, ALA104C, ALA111C, ALA113C, ALA136C, ALA146C, ALA290C, ALA315A, ALA362A, ALA436A, ARG114C, ARG135C, ARG141C, ARG142C, ARG312A, ARG317A, ARG393A, ASN147C, ASN283C, ASN324A, ASP105C, ASP145C, ASP320A, ASP328A, ASP359A, GLN118C, GLN390A, GLN458A, GLU110C, GLU138C, GLU360A, GLU460A, GLY361A, GLY456A, GLY97C, GLY99C, HIS409A, HIS429A, ILE109C, ILE140C, ILE143C, ILE318A, ILE319A, LEU106C, LEU322A, LEU394A, LEU433A, LYS100C, LYS107C, LYS329A, LYS434A, LYS94C, MET358A, MET432A, MET98C, PHE144C, PHE323A, PHE437A, PHE439A, PRO435A, PRO92C, SER139C, SER316A, SER321A, THR148C, THR325A, THR327A, THR91C, THR95C, TYR108C, TYR286C, TYR356A, TYR96C, VAL117C, VAL134C, VAL326A
• B-F: ALA103F, ALA104F, ALA111F, ALA113F, ALA136F, ALA146F, ALA290F, ALA315B, ALA362B, ALA408B, ALA436B, ARG102F, ARG114F, ARG135F, ARG141F, ARG142F, ARG312B, ARG317B, ARG393B, ASN147F, ASN283F, ASN324B, ASP105F, ASP145F, ASP320B, ASP328B, ASP359B, GLN118F, GLN390B, GLN458B, GLU110F, GLU138F, GLU360B, GLU460B, GLY361B, GLY456B, GLY97F, GLY99F, HIS409B, HIS429B, ILE109F, ILE140F, ILE143F, ILE318B, ILE319B, LEU106F, LEU322B, LEU357B, LEU394B, LEU433B, LYS100F, LYS107F, LYS329B, LYS434B, LYS94F, MET358B, MET432B, MET98F, PHE144F, PHE323B, PHE437B, PHE439B, PRO435B, SER139F, SER316B, SER321B, THR148F, THR325B, THR327B, THR95F, TYR108F, TYR286F, TYR356B, TYR96F, VAL117F, VAL326B
• B-D: ALA103B, ALA104B, ALA111B, ALA113B, ALA136B, ALA146B, ALA290B, ALA315D, ALA362D, ALA436D, ARG102B, ARG114B, ARG135B, ARG141B, ARG142B, ARG312D, ARG313D, ARG317D, ARG393D, ASN147B, ASN283B, ASN324D, ASP105B, ASP145B, ASP320D, ASP328D, ASP359D, GLN118B, GLN390D, GLN458D, GLU110B, GLU138B, GLU360D, GLU460D, GLY361D, GLY456D, GLY97B, GLY99B, HIS409D, HIS429D, ILE109B, ILE140B, ILE143B, ILE318D, ILE319D, LEU106B, LEU322D, LEU357D, LEU394D, LEU433D, LYS100B, LYS107B, LYS329D, LYS434D, LYS94B, MET358D, MET432D, MET98B, PHE144B, PHE323D, PHE437D, PHE439D, PRO435D, PRO92B, SER139B, SER316D, SER321D, THR148B, THR325D, THR327D, THR91B, THR95B, TYR108B, TYR286B, TYR356D, TYR96B, VAL117B, VAL326D, VAL466D
• B-C: ALA290B, ALA290C, ASN292B, ASN292C, LEU291B, LEU291C, LEU293B, LEU293C, PRO294B, PRO294C
• G-H: ALA164G, ALA164H, ALA222G, ALA222H, ALA223G, ALA223H, ALA225G, ALA225H, ALA228G, ALA228H, ALA239G, ALA239H, ALA243G, ALA243H, ALA246G, ALA246H, ALA252G, ALA252H, ALA254G, ALA254H, ALA297G, ALA297H, ARG135G, ARG135H, ARG177G, ARG177H, ARG205G, ARG205H, ARG230G, ARG230H, ARG260G, ARG260H, ARG298G, ARG298H, ARG312G, ARG312H, ARG313G, ARG313H, ASN174G, ASN174H, ASN212G, ASN212H, ASN224G, ASN224H, ASN235G, ASN235H, ASN263G, ASN263H, ASN283G, ASN283H, ASN292G, ASN292H, ASN307G, ASN307H, ASP171G, ASP171H, ASP176G, ASP176H, ASP247G, ASP247H, ASP258G, ASP258H, ASP305G, ASP305H, ASP308G, ASP308H, CYS241G, CYS241H, CYS276H, CYS288G, CYS288H, GLN229G, GLN229H, GLN259G, GLN259H, GLN301G, GLN301H, GLN302G, GLN302H, GLN310G, GLN310H, GLU165G, GLU165H, GLU184G, GLU184H, GLU206G, GLU206H, GLU217G, GLU217H, GLU242G, GLU242H, GLU250G, GLU250H, GLU289G, GLU289H, GLU295G, GLU295H, GLY245G, GLY245H, GLY256G, GLY256H, GLY262G, GLY262H, ILE208G, ILE208H, ILE231G, ILE231H, ILE234G, ILE234H, ILE237G, ILE237H, ILE255G, ILE255H, ILE261G, ILE261H, ILE304G, ILE304H, LEU163G, LEU163H, LEU179G, LEU179H, LEU209G, LEU209H, LEU218G, LEU218H, LEU221G, LEU221H, LEU227G, LEU227H, LEU240G, LEU240H, LEU266G, LEU266H, LEU284G, LEU284H, LEU287G, LEU287H, LEU291G, LEU291H, LEU293G, LEU293H, LYS207G, LYS207H, LYS220G, LYS220H, LYS264G, LYS264H, LYS339G, LYS339H, LYS465G, LYS465H, MET257G, MET257H, MET306G, MET306H, PHE162G, PHE162H, PHE226G, PHE226H, PHE265G, PHE265H, PHE272G, PHE272H, PHE277G, PHE277H, PRO160G, PRO160H, PRO175G, PRO175H, PRO294G, PRO294H, SER215G, SER215H, SER216G, SER216H, SER219G, SER219H, SER232G, SER232H, SER233G, SER233H, SER236G, SER236H, SER238G, SER238H, THR167G, THR167H, THR210G, THR210H, THR211G, THR211H, THR244G, THR244H, THR253G, THR253H, TRP214G, TRP214H, TRP300G, TRP300H, TYR299G, TYR299H, TYR309G, TYR309H, VAL178G, VAL178H, VAL248G, VAL248H, VAL251G, VAL251H, VAL285G, VAL285H, VAL296G, VAL296H, VAL303G, VAL303H
• G-L: ALA290G, ASN292G, ASN292L, GLU289G, LEU291G, LEU291L, LEU293G, LEU293L, PRO294G, PRO294L
• G-K: ALA103G, ALA104G, ALA111G, ALA113G, ALA146G, ALA290G, ALA315K, ALA362K, ALA408K, ALA436K, ARG102G, ARG114G, ARG135G, ARG141G, ARG142G, ARG312K, ARG313K, ARG317K, ARG393K, ASN147G, ASN283G, ASN324K, ASP105G, ASP145G, ASP320K, ASP328K, ASP359K, GLN118G, GLN390K, GLN458K, GLU110G, GLU138G, GLU360K, GLU460K, GLY361K, GLY456K, GLY97G, GLY99G, HIS409K, HIS429K, ILE109G, ILE140G, ILE143G, ILE319K, LEU106G, LEU322K, LEU357K, LEU394K, LEU433K, LYS100G, LYS107G, LYS329K, LYS434K, LYS94G, MET358K, MET432K, MET98G, PHE144G, PHE323K, PHE437K, PHE439K, PRO435K, PRO92G, SER139G, SER316K, SER321K, THR148G, THR325K, THR327K, THR95G, TYR108G, TYR286G, TYR356K, TYR96G, VAL117G, VAL134G, VAL326K, VAL466K
• G-I: ALA103I, ALA104I, ALA111I, ALA113I, ALA136I, ALA146I, ALA290I, ALA315G, ALA362G, ALA408G, ALA436G, ARG114I, ARG135I, ARG141I, ARG142I, ARG312G, ARG313G, ARG317G, ARG393G, ASN147I, ASN283I, ASN324G, ASP105I, ASP145I, ASP320G, ASP328G, ASP359G, GLN118I, GLN390G, GLN458G, GLU110I, GLU138I, GLU360G, GLU460G, GLY361G, GLY456G, GLY97I, GLY99I, HIS409G, HIS429G, ILE109I, ILE140I, ILE143I, ILE319G, LEU106I, LEU322G, LEU394G, LEU433G, LYS100I, LYS107I, LYS329G, LYS434G, LYS94I, MET358G, MET432G, MET98I, PHE144I, PHE323G, PHE437G, PHE439G, PRO435G, PRO92I, SER139I, SER316G, SER321G, THR148I, THR325G, THR327G, THR91I, THR95I, TYR108I, TYR286I, TYR356G, TYR96I, VAL117I, VAL134I, VAL326G, VAL466G
• H-L: ALA103L, ALA104L, ALA111L, ALA113L, ALA136L, ALA146L, ALA290L, ALA315H, ALA362H, ALA408H, ALA436H, ARG102L, ARG114L, ARG135L, ARG141L, ARG142L, ARG312H, ARG317H, ARG393H, ASN147L, ASN283L, ASN324H, ASP105L, ASP145L, ASP320H, ASP328H, ASP359H, GLN118L, GLN390H, GLN458H, GLU110L, GLU138L, GLU360H, GLU460H, GLY361H, GLY456H, GLY97L, GLY99L, HIS409H, HIS429H, ILE109L, ILE140L, ILE143L, ILE318H, ILE319H, LEU106L, LEU322H, LEU357H, LEU394H, LEU433H, LYS100L, LYS107L, LYS329H, LYS434H, LYS94L, MET358H, MET432H, MET98L, PHE144L, PHE323H, PHE437H, PHE439H, PRO435H, PRO92L, SER139L, SER316H, SER321H, THR148L, THR325H, THR327H, THR91L, THR95L, TYR108L, TYR286L, TYR356H, TYR96L, VAL117L, VAL134L, VAL326H, VAL466H
• H-J: ALA103H, ALA104H, ALA111H, ALA113H, ALA136H, ALA146H, ALA290H, ALA315J, ALA362J, ALA408J, ALA436J, ARG102H, ARG114H, ARG135H, ARG141H, ARG142H, ARG312J, ARG313J, ARG317J, ARG393J, ASN147H, ASN283H, ASN324J, ASP105H, ASP145H, ASP320J, ASP328J, ASP359J, GLN118H, GLN390J, GLN458J, GLU110H, GLU138H, GLU360J, GLY361J, GLY456J, GLY97H, GLY99H, HIS409J, HIS429J, ILE109H, ILE140H, ILE143H, ILE319J, LEU106H, LEU322J, LEU357J, LEU394J, LEU433J, LYS100H, LYS107H, LYS329J, LYS434J, LYS94H, MET358J, MET432J, MET98H, PHE144H, PHE323J, PHE437J, PRO435J, SER139H, SER316J, SER321J, THR148H, THR325J, THR327J, THR91H, THR95H, TYR108H, TYR286H, TYR356J, TYR96H, VAL117H, VAL134H, VAL326J
• H-I: ALA290H, ASN292H, ASN292I, LEU291H, LEU291I, LEU293H, LEU293I, PRO294H, PRO294I
• L-K: ALA164K, ALA164L, ALA222K, ALA222L, ALA223K, ALA223L, ALA225K, ALA225L, ALA228K, ALA228L, ALA239K, ALA239L, ALA243K, ALA243L, ALA246K, ALA246L, ALA252K, ALA252L, ALA254K, ALA254L, ALA297K, ALA297L, ARG135K, ARG135L, ARG177K, ARG177L, ARG205K, ARG230K, ARG230L, ARG260K, ARG260L, ARG298K, ARG298L, ARG312K, ARG312L, ARG313K, ARG313L, ASN174L, ASN212K, ASN212L, ASN224K, ASN224L, ASN235K, ASN235L, ASN263K, ASN263L, ASN283K, ASN292K, ASN292L, ASN307K, ASN307L, ASP171K, ASP171L, ASP176K, ASP176L, ASP247K, ASP247L, ASP258K, ASP258L, ASP305K, ASP305L, ASP308K, ASP308L, CYS241K, CYS241L, CYS288K, CYS288L, GLN229K, GLN229L, GLN259K, GLN259L, GLN301K, GLN301L, GLN302K, GLN302L, GLN310K, GLN310L, GLU165K, GLU165L, GLU184K, GLU184L, GLU206K, GLU206L, GLU217K, GLU217L, GLU242K, GLU242L, GLU250K, GLU250L, GLU289L, GLU295K, GLU295L, GLY245K, GLY245L, GLY256K, GLY256L, GLY262K, GLY262L, ILE208K, ILE208L, ILE231K, ILE231L, ILE234K, ILE234L, ILE237K, ILE237L, ILE255K, ILE255L, ILE261K, ILE261L, ILE304K, ILE304L, LEU163K, LEU163L, LEU179K, LEU179L, LEU209K, LEU209L, LEU218K, LEU218L, LEU221K, LEU221L, LEU227K, LEU227L, LEU240K, LEU240L, LEU266K, LEU266L, LEU284K, LEU284L, LEU287K, LEU287L, LEU291K, LEU291L, LEU293K, LEU293L, LYS207K, LYS207L, LYS220K, LYS220L, LYS264K, LYS264L, LYS339K, LYS339L, LYS465K, LYS465L, MET257K, MET257L, MET306K, MET306L, PHE162K, PHE162L, PHE226K, PHE226L, PHE265K, PHE265L, PHE272K, PHE272L, PHE277K, PHE277L, PRO160K, PRO160L, PRO175K, PRO175L, PRO204K, PRO294K, PRO294L, SER215K, SER215L, SER216K, SER216L, SER219K, SER219L, SER232K, SER232L, SER233K, SER233L, SER236K, SER236L, SER238K, SER238L, THR167K, THR167L, THR210K, THR210L, THR211K, THR211L, THR244K, THR244L, THR253K, THR253L, TRP214K, TRP214L, TRP300K, TRP300L, TYR299K, TYR299L, TYR309K, TYR309L, VAL178K, VAL178L, VAL248K, VAL248L, VAL251K, VAL251L, VAL285K, VAL285L, VAL296K, VAL296L, VAL303K, VAL303L
• L-D: ALA191D, ALA436L, ARG190D, ASN121D, ASN151D, ASN153D, ASN450L, ASP424L, ASP83D, GLN155D, GLN189D, GLN453L, GLU187D, GLU3D, GLU426L, GLU451L, GLY122D, GLY188D, GLY456L, HIS409L, HIS429L, ILE455L, ILE4D, LEU152D, LEU433L, LEU452L, LYS430L, LYS434L, LYS5D, MET1D, MET432L, PHE2D, PHE457L, PRO150D, PRO186D, PRO435L, THR185D, THR454L, TYR123D, TYR425L
• K-C: ALA191K, ALA436C, ARG190K, ASN151K, ASN153K, ASN450C, ASP83K, GLN189K, GLN453C, GLU187K, GLU3K, GLU426C, GLU451C, GLY122K, GLY188K, GLY456C, HIS429C, ILE455C, ILE4K, LEU152K, LEU433C, LYS430C, LYS434C, LYS5K, MET1K, PHE2K, PHE457C, PRO150K, PRO186K, PRO435C, THR185K, THR454C, TYR123K, TYR425C
• F-E: ALA164E, ALA164F, ALA222E, ALA222F, ALA223E, ALA223F, ALA225E, ALA225F, ALA228E, ALA228F, ALA239E, ALA239F, ALA243E, ALA243F, ALA246E, ALA246F, ALA252E, ALA252F, ALA254E, ALA254F, ALA297E, ALA297F, ARG135E, ARG135F, ARG177E, ARG177F, ARG205E, ARG230E, ARG230F, ARG260E, ARG260F, ARG298E, ARG298F, ARG312E, ARG312F, ARG313E, ARG313F, ASN174E, ASN212E, ASN212F, ASN224E, ASN224F, ASN235E, ASN235F, ASN263E, ASN263F, ASN283E, ASN292E, ASN292F, ASN307E, ASN307F, ASP171E, ASP171F, ASP176E, ASP176F, ASP247E, ASP247F, ASP258E, ASP258F, ASP305E, ASP305F, ASP308E, ASP308F, CYS241E, CYS241F, CYS288E, CYS288F, GLN229E, GLN229F, GLN259E, GLN259F, GLN301E, GLN301F, GLN302E, GLN302F, GLN310E, GLN310F, GLU165E, GLU165F, GLU184E, GLU184F, GLU206E, GLU206F, GLU217E, GLU217F, GLU242E, GLU242F, GLU250E, GLU250F, GLU289E, GLU289F, GLU295E, GLU295F, GLY245E, GLY245F, GLY256E, GLY256F, GLY262E, GLY262F, ILE208E, ILE208F, ILE231E, ILE231F, ILE234E, ILE234F, ILE237E, ILE237F, ILE255E, ILE255F, ILE261E, ILE261F, ILE304E, ILE304F, LEU163E, LEU163F, LEU179E, LEU179F, LEU209E, LEU209F, LEU218E, LEU218F, LEU221E, LEU221F, LEU227E, LEU227F, LEU240E, LEU240F, LEU266E, LEU266F, LEU284E, LEU284F, LEU287E, LEU287F, LEU291E, LEU291F, LEU293E, LEU293F, LYS170F, LYS207E, LYS207F, LYS220E, LYS220F, LYS264E, LYS264F, LYS339E, LYS339F, LYS465E, LYS465F, MET257E, MET257F, MET306E, MET306F, PHE162E, PHE162F, PHE226E, PHE226F, PHE265E, PHE265F, PHE272E, PHE272F, PHE277E, PHE277F, PRO160E, PRO160F, PRO175E, PRO175F, PRO204E, PRO294E, PRO294F, SER215E, SER215F, SER216E, SER216F, SER219E, SER219F, SER232E, SER232F, SER233E, SER233F, SER236E, SER236F, SER238E, SER238F, THR167E, THR167F, THR210E, THR210F, THR211E, THR211F, THR244E, THR244F, THR253E, THR253F, TRP214E, TRP214F, TRP300E, TRP300F, TYR299E, TYR299F, TYR309E, TYR309F, VAL178E, VAL178F, VAL248E, VAL248F, VAL251E, VAL251F, VAL285E, VAL285F, VAL296E, VAL296F, VAL303E, VAL303F
• F-J: ALA191J, ALA436F, ARG190J, ASN121J, ASN151J, ASN153J, ASN450F, ASP424F, ASP83J, GLN155J, GLN189J, GLN453F, GLU187J, GLU3J, GLU426F, GLU451F, GLY122J, GLY188J, GLY456F, HIS409F, HIS429F, ILE455F, ILE4J, LEU152J, LEU433F, LEU452F, LYS430F, LYS434F, LYS5J, MET1J, MET432F, PHE2J, PHE323F, PHE457F, PRO150J, PRO186J, PRO435F, THR185J, THR454F, TYR123J, TYR425F
• E-I: ALA191E, ARG190E, ASN151E, ASN153E, ASN450I, ASP424I, ASP83E, GLN189E, GLN453I, GLU187E, GLU3E, GLU426I, GLU451I, GLY122E, GLY188E, GLY456I, HIS429I, ILE455I, ILE4E, LEU152E, LEU433I, LYS430I, LYS434I, LYS5E, MET1E, MET432I, PHE2E, PHE457I, PRO150E, PRO186E, PRO435I, THR185E, THR454I, TYR123E, TYR425I
• D-C: ALA164C, ALA164D, ALA222C, ALA222D, ALA223C, ALA223D, ALA225C, ALA225D, ALA228C, ALA228D, ALA239C, ALA239D, ALA243C, ALA243D, ALA246C, ALA246D, ALA252C, ALA252D, ALA254C, ALA254D, ALA297C, ALA297D, ARG135C, ARG135D, ARG177C, ARG177D, ARG205C, ARG205D, ARG230C, ARG230D, ARG260C, ARG260D, ARG298C, ARG298D, ARG312C, ARG312D, ARG313C, ARG313D, ASN174C, ASN174D, ASN212C, ASN212D, ASN224C, ASN224D, ASN235C, ASN235D, ASN263C, ASN263D, ASN292C, ASN292D, ASN307C, ASN307D, ASP171C, ASP171D, ASP176C, ASP176D, ASP247C, ASP247D, ASP258C, ASP258D, ASP305C, ASP305D, ASP308C, ASP308D, CYS241C, CYS241D, CYS288C, CYS288D, GLN229C, GLN229D, GLN259C, GLN259D, GLN301C, GLN301D, GLN302C, GLN302D, GLN310C, GLN310D, GLU165D, GLU184C, GLU184D, GLU206C, GLU206D, GLU217C, GLU217D, GLU242C, GLU242D, GLU250C, GLU250D, GLU289C, GLU289D, GLU295C, GLU295D, GLY245C, GLY245D, GLY256C, GLY256D, GLY262C, GLY262D, ILE208C, ILE208D, ILE231C, ILE231D, ILE234C, ILE234D, ILE237C, ILE237D, ILE255C, ILE255D, ILE261C, ILE261D, ILE304C, ILE304D, LEU163C, LEU163D, LEU179C, LEU179D, LEU209C, LEU209D, LEU218C, LEU218D, LEU221C, LEU221D, LEU227C, LEU227D, LEU240C, LEU240D, LEU266C, LEU266D, LEU284C, LEU284D, LEU287C, LEU287D, LEU291C, LEU291D, LEU293C, LEU293D, LYS207C, LYS207D, LYS220C, LYS220D, LYS264C, LYS264D, LYS339C, LYS339D, LYS465C, LYS465D, MET257C, MET257D, MET306C, MET306D, PHE162C, PHE162D, PHE226C, PHE226D, PHE265C, PHE265D, PHE272C, PHE272D, PHE277C, PHE277D, PRO160C, PRO160D, PRO175C, PRO175D, PRO204C, PRO294C, PRO294D, SER215C, SER215D, SER216C, SER216D, SER219C, SER219D, SER232C, SER232D, SER233C, SER233D, SER236C, SER236D, SER238C, SER238D, THR167C, THR167D, THR210C, THR210D, THR211C, THR211D, THR244C, THR244D, THR253C, THR253D, TRP214C, TRP214D, TRP300C, TRP300D, TYR299C, TYR299D, TYR309C, TYR309D, VAL178C, VAL178D, VAL248C, VAL248D, VAL251C, VAL251D, VAL285C, VAL296C, VAL296D, VAL303C, VAL303D
• J-I: ALA164I, ALA164J, ALA222I, ALA222J, ALA223I, ALA223J, ALA225I, ALA225J, ALA228I, ALA228J, ALA239I, ALA239J, ALA243I, ALA243J, ALA246I, ALA246J, ALA252I, ALA252J, ALA254I, ALA254J, ALA290I, ALA290J, ALA297I, ALA297J, ARG135I, ARG135J, ARG177I, ARG177J, ARG205I, ARG205J, ARG230I, ARG230J, ARG260I, ARG260J, ARG298I, ARG298J, ARG312I, ARG312J, ARG313I, ARG313J, ASN174I, ASN174J, ASN212I, ASN212J, ASN224I, ASN224J, ASN235I, ASN235J, ASN263I, ASN263J, ASN292I, ASN292J, ASN307I, ASN307J, ASP171I, ASP171J, ASP176I, ASP176J, ASP247I, ASP247J, ASP258I, ASP258J, ASP305I, ASP305J, ASP308I, ASP308J, CYS241I, CYS241J, CYS276I, CYS288I, CYS288J, GLN229I, GLN229J, GLN259I, GLN259J, GLN301I, GLN301J, GLN302I, GLN302J, GLN310I, GLN310J, GLU165J, GLU184J, GLU206I, GLU206J, GLU217I, GLU217J, GLU242I, GLU242J, GLU250I, GLU250J, GLU289I, GLU289J, GLU295I, GLU295J, GLY245I, GLY245J, GLY256I, GLY256J, GLY262I, GLY262J, ILE208I, ILE208J, ILE231I, ILE231J, ILE234I, ILE234J, ILE237I, ILE237J, ILE255I, ILE255J, ILE261I, ILE261J, ILE304I, ILE304J, LEU163I, LEU163J, LEU179I, LEU179J, LEU209I, LEU209J, LEU218I, LEU218J, LEU221I, LEU221J, LEU227I, LEU227J, LEU240I, LEU240J, LEU266I, LEU266J, LEU284I, LEU284J, LEU287I, LEU287J, LEU291I, LEU291J, LEU293I, LEU293J, LYS207I, LYS207J, LYS220I, LYS220J, LYS264I, LYS264J, LYS339I, LYS339J, LYS464J, LYS465I, LYS465J, MET257I, MET257J, MET306I, MET306J, PHE162I, PHE162J, PHE226I, PHE226J, PHE265I, PHE265J, PHE272I, PHE272J, PHE277I, PHE277J, PRO160I, PRO160J, PRO175I, PRO175J, PRO204I, PRO294I, PRO294J, SER215I, SER215J, SER216I, SER216J, SER219I, SER219J, SER232I, SER232J, SER233I, SER233J, SER236I, SER236J, SER238I, SER238J, THR167I, THR167J, THR210I, THR210J, THR211I, THR211J, THR244I, THR244J, THR253I, THR253J, TRP214I, TRP214J, TRP300I, TRP300J, TYR299I, TYR299J, TYR309I, TYR309J, VAL178I, VAL178J, VAL248I, VAL248J, VAL251I, VAL251J, VAL285I, VAL285J, VAL296I, VAL296J, VAL303I, VAL303J