3T8W

a bestatin-based chemical biology strategy reveals distinct roles for malaria m1- and m17-family aminopeptidases

• Total interactions analyzed: 66
• Total true interactions: 26
• Strongest Interaction:
  • Chains: H-I
  • Int. Res.: 145
  • Norm. En. per Res.: -4.0109
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-90.1539	-30.2861	-408.704	-529.1439	144	21	12	16216	4	31	31
A-C	-94.7492	-14.9244	-424.499	-534.1726	148	17	12	16650	4	34	33
A-D	-73.0202	-7.2366	-220.078	-300.3348	105	13	4	8756	0	27	34
A-F	-50.0193	38.7748	-293.711	-304.9555	110	7	9	10828	0	17	15
B-C	-123.5402	-21.3181	-434.041	-578.8993	145	16	12	16850	4	34	33
B-E	-29.0831	29.5118	-284.962	-284.5333	110	12	10	10959	0	17	17
B-F	-62.8521	-2.1826	-199.94	-264.9747	93	9	4	7812	0	27	35
C-D	-20.0436	25.3152	-270.619	-265.3474	103	10	10	10088	1	14	16
C-E	-58.9134	-7.8699	-216.563	-283.3464	93	8	4	8267	0	26	35
D-E	-96.109	-30.7639	-395.003	-521.8759	140	16	12	15940	4	29	28
D-F	-82.5413	-29.0314	-394.515	-506.0877	142	23	12	15881	4	30	28
E-F	-87.7186	-29.2788	-395.684	-512.6814	140	16	12	15805	4	30	28
F-I	0.0	-0.8653	-4.7622	-5.6276	30	0	0	727	0	31	28
F-K	0.0	0.0	-3.941	-3.941	16	0	0	325	0	14	15
G-H	-104.3912	-18.794	-429.891	-553.0762	147	24	12	16723	4	35	34
G-I	-94.373	-22.2804	-432.412	-549.0654	148	18	12	16827	4	34	33
G-J	-55.3705	-5.6396	-217.548	-278.5582	103	8	4	8518	0	27	33
G-L	-41.4972	37.0727	-271.99	-276.4146	106	4	10	10014	0	15	16
H-I	-130.2437	-16.7045	-434.639	-581.5872	145	17	12	16864	5	34	34
H-K	-20.4856	28.9566	-290.437	-281.966	108	12	10	10933	0	15	16
H-L	-39.2535	-2.7132	-178.583	-220.5497	90	8	4	6796	1	26	31
I-J	-19.9202	33.1989	-277.192	-263.9133	106	10	10	10288	0	16	16
I-K	-48.5317	-9.8937	-202.863	-261.2884	93	5	4	7912	1	27	35
J-K	-115.2542	-31.2748	-402.893	-549.4221	141	16	12	15890	4	30	28
J-L	-85.0323	-29.0458	-390.492	-504.57	140	22	12	15803	4	30	28
K-L	-92.4242	-29.6796	-394.837	-516.9407	140	18	12	15729	4	30	28

Interface residues

• A-B: ALA299B, ALA300B, ALA340A, ALA387A, ALA387B, ALA388A, ALA388B, ALA447A, ALA535A, ALA542A, ALA585B, ARG251B, ARG440A, ARG586B, ASN303B, ASN306B, ASN352A, ASN384A, ASN432B, ASN437A, ASN437B, ASN449A, ASN457A, ASN538A, ASN545A, ASN582B, ASP249B, ASP379B, ASP394B, ASP443A, ASP468A, ASP543A, ASP95B, CYS305B, GLN296B, GLN90B, GLU245B, GLU250B, GLU332A, GLU334A, GLU335A, GLU431B, GLU454A, GLY339A, GLY345A, GLY345B, GLY347A, GLY347B, GLY381B, GLY382A, GLY382B, GLY442A, GLY450A, GLY456A, HIS215B, ILE298B, ILE393B, ILE444A, ILE445A, ILE453A, ILE544A, ILE547A, LEU333A, LEU336A, LEU342A, LEU385A, LEU385B, LEU395B, LEU537A, LEU94B, LYS253B, LYS257B, LYS331A, LYS337A, LYS346A, LYS346B, LYS386A, LYS386B, LYS397B, LYS436A, LYS436B, LYS451A, LYS540A, LYS584B, LYS587B, MET247B, MET338A, MET349A, MET349B, MET392B, MET396B, MET433B, PHE252B, PHE378B, PHE398B, PRO301B, PRO307B, PRO351A, PRO389A, PRO389B, PRO441A, PRO588B, PRO89B, PRO96B, SER254B, SER295B, SER302B, SER343A, SER348A, SER348B, SER380B, SER391B, SER435A, SER435B, SER438A, SER438B, SER448A, SER539A, SER549A, SER93B, THR248B, THR255B, THR377B, THR446A, THR452A, THR458A, THR536A, TRP581B, TYR244B, TYR292B, TYR304B, TYR341A, TYR350B, TYR383A, TYR383B, TYR439A, TYR541A, VAL330A, VAL434A, VAL434B, VAL455A, VAL91A, VAL91B, VAL92B
• A-C: ALA299A, ALA300A, ALA340C, ALA387A, ALA387C, ALA388A, ALA388C, ALA447C, ALA535C, ALA542C, ALA585A, ARG251A, ARG440C, ARG534C, ARG586A, ASN303A, ASN306A, ASN352C, ASN384C, ASN432A, ASN437A, ASN437C, ASN449C, ASN457C, ASN538C, ASN545C, ASN582A, ASP249A, ASP256A, ASP379A, ASP394A, ASP443C, ASP468C, ASP543C, ASP95A, CYS305A, GLN296A, GLN90A, GLU245A, GLU250A, GLU332C, GLU334C, GLU335C, GLU431A, GLU454C, GLU564C, GLY339C, GLY345A, GLY345C, GLY347A, GLY347C, GLY381A, GLY382A, GLY382C, GLY442C, GLY450C, GLY456C, HIS215A, ILE298A, ILE393A, ILE444C, ILE445C, ILE453C, ILE544C, ILE547C, LEU333C, LEU336C, LEU342C, LEU385A, LEU385C, LEU395A, LEU537C, LEU94A, LYS253A, LYS257A, LYS331C, LYS337C, LYS346A, LYS346C, LYS386A, LYS386C, LYS397A, LYS436A, LYS436C, LYS451C, LYS540C, LYS584A, LYS587A, MET247A, MET338C, MET349A, MET349C, MET392A, MET396A, MET433A, PHE252A, PHE378A, PHE398A, PRO301A, PRO307A, PRO351C, PRO389A, PRO389C, PRO441C, PRO588A, PRO89A, PRO96A, SER254A, SER295A, SER302A, SER343C, SER348A, SER348C, SER380A, SER391A, SER435A, SER435C, SER438A, SER438C, SER448C, SER539C, SER549C, SER93A, THR248A, THR255A, THR377A, THR446C, THR452C, THR458C, THR536C, TRP581A, TYR244A, TYR292A, TYR304A, TYR341C, TYR350A, TYR383A, TYR383C, TYR439C, TYR541C, VAL330C, VAL344C, VAL434A, VAL434C, VAL455C, VAL91A, VAL91C, VAL92A
• A-D: ALA186A, ALA186D, ASN139A, ASN139D, ASN161A, ASN161D, ASN166A, ASN166D, ASN183A, ASN217A, ASN217D, ASN258A, ASN260A, ASN260D, ASP216A, ASP216D, ASP256A, GLN152A, GLN152D, GLU125A, GLU138D, GLU155A, GLU155D, GLU160A, GLU160D, GLU163A, GLU163D, GLU262A, GLY126A, GLY140D, GLY188A, HIS174A, HIS174D, HIS215A, HIS215D, ILE129A, ILE264A, LEU127A, LEU127D, LEU157A, LEU157D, LEU214A, LEU214D, LEU219A, LEU219D, LYS137D, LYS151D, LYS158A, LYS158D, LYS164A, LYS164D, LYS168A, LYS168D, LYS173A, LYS173D, LYS182A, LYS182D, LYS218A, LYS218D, LYS221A, LYS257A, MET162A, MET162D, MET177A, MET177D, MET213A, MET213D, MET261A, MET261D, PHE156A, PHE156D, PHE165A, PHE165D, PHE175A, PHE175D, PHE178A, PHE178D, PRO141A, PRO141D, PRO389A, PRO389D, SER154D, SER172A, SER172D, SER184A, SER184D, SER220A, THR128A, THR171A, THR171D, THR212A, THR212D, TYR176A, TYR176D, TYR189A, TYR189D, VAL142D, VAL153D, VAL167D, VAL185A, VAL185D, VAL187A, VAL187D, VAL211A, VAL259A
• A-F: ALA201A, ALA201F, ALA490A, ALA490F, ALA500A, ALA500F, ALA535A, ALA535F, ALA553A, ALA553F, ARG205A, ARG205F, ASN531A, ASN531F, ASN538A, ASN538F, ASP202A, ASP202F, GLU200A, GLU200F, GLU507A, GLU507F, GLU532A, GLU532F, GLY489A, GLY489F, GLY496A, GLY496F, GLY578A, GLY578F, ILE510A, ILE510F, ILE529A, ILE529F, ILE530A, ILE530F, ILE556A, ILE556F, LEU169F, LEU208A, LEU208F, LEU395A, LEU492A, LEU492F, LEU495A, LEU495F, LEU514A, LEU514F, LEU527A, LEU527F, LYS168A, LYS168F, LYS204A, LYS204F, LYS552A, LYS552F, LYS584A, LYS589A, LYS589F, MET392A, MET491A, MET491F, PHE503A, PHE503F, PHE583A, PHE583F, PRO523A, PRO523F, PRO528A, PRO528F, SER199A, SER199F, SER494A, SER494F, SER498A, SER498F, SER550A, SER550F, SER554A, SER554F, SER555A, SER555F, THR488A, THR488F, THR497A, THR497F, THR536A, THR536F, TRP525A, TRP525F, TRP526A, TRP526F, TRP581A, TYR493A, TYR493F, TYR499A, TYR499F, TYR533A, TYR533F, VAL195F, VAL502A, VAL502F, VAL524A, VAL524F, VAL551A, VAL551F, VAL557A, VAL557F, VAL579A, VAL579F
• B-C: ALA299C, ALA300C, ALA340B, ALA387B, ALA387C, ALA388B, ALA388C, ALA447B, ALA535B, ALA542B, ALA585C, ARG251C, ARG440B, ARG534B, ARG586C, ASN303C, ASN306C, ASN352B, ASN384B, ASN432C, ASN437B, ASN437C, ASN449B, ASN457B, ASN538B, ASN545B, ASN582C, ASP249C, ASP256C, ASP379C, ASP394C, ASP443B, ASP468B, ASP543B, ASP95C, CYS305C, GLN296C, GLN90C, GLU245C, GLU250C, GLU334B, GLU335B, GLU431C, GLU454B, GLY339B, GLY345B, GLY345C, GLY347B, GLY347C, GLY381C, GLY382B, GLY382C, GLY442B, GLY450B, GLY456B, HIS215C, ILE298C, ILE393C, ILE444B, ILE445B, ILE453B, ILE544B, ILE547B, LEU333B, LEU336B, LEU342B, LEU385B, LEU385C, LEU395C, LEU537B, LEU94C, LYS253C, LYS257C, LYS331B, LYS337B, LYS346B, LYS346C, LYS386B, LYS386C, LYS397C, LYS436B, LYS436C, LYS451B, LYS540B, LYS584C, LYS587C, MET247C, MET338B, MET349C, MET392C, MET396C, MET433C, PHE252C, PHE378C, PHE398C, PHE565B, PRO301C, PRO307C, PRO351B, PRO389B, PRO389C, PRO441B, PRO588C, PRO89C, PRO96C, SER254C, SER295C, SER302C, SER343B, SER348B, SER348C, SER380C, SER391C, SER435B, SER435C, SER438B, SER438C, SER448B, SER539B, SER549B, SER93C, THR248C, THR255C, THR377C, THR446B, THR452B, THR458B, THR536B, TRP581C, TYR244C, TYR292C, TYR304C, TYR341B, TYR350C, TYR383B, TYR383C, TYR439B, TYR541B, VAL330B, VAL434B, VAL434C, VAL455B, VAL91B, VAL91C, VAL92C
• B-E: ALA201B, ALA201E, ALA490B, ALA490E, ALA500B, ALA500E, ALA535B, ALA535E, ALA553B, ALA553E, ARG205B, ARG205E, ASN531B, ASN531E, ASN538B, ASN538E, ASP202B, ASP202E, GLU200B, GLU200E, GLU507B, GLU507E, GLU532B, GLU532E, GLY489B, GLY489E, GLY496B, GLY496E, GLY578B, GLY578E, ILE510B, ILE510E, ILE529B, ILE529E, ILE530B, ILE530E, ILE556B, ILE556E, LEU169E, LEU208E, LEU395B, LEU492B, LEU492E, LEU495B, LEU495E, LEU514B, LEU514E, LEU527B, LEU527E, LYS168E, LYS204B, LYS204E, LYS518E, LYS552B, LYS552E, LYS584B, LYS584E, LYS589B, LYS589E, MET392B, MET491B, MET491E, PHE503B, PHE503E, PHE583B, PHE583E, PRO523B, PRO523E, PRO528B, PRO528E, SER199B, SER199E, SER494B, SER494E, SER498B, SER498E, SER550B, SER550E, SER554B, SER554E, SER555B, SER555E, THR488B, THR488E, THR497B, THR497E, THR536B, THR536E, TRP525B, TRP525E, TRP526B, TRP526E, TRP581B, TYR493B, TYR493E, TYR499B, TYR499E, TYR533B, TYR533E, VAL195E, VAL502B, VAL502E, VAL524B, VAL524E, VAL551B, VAL551E, VAL557B, VAL557E, VAL579B, VAL579E
• B-F: ALA186B, ALA186F, ASN139F, ASN161B, ASN161F, ASN166B, ASN166F, ASN179F, ASN183F, ASN217B, ASN217F, ASN258B, ASN260B, ASP216B, ASP216F, GLN152B, GLN152F, GLU138F, GLU155B, GLU155F, GLU160B, GLU163F, GLY126B, GLY140F, GLY188B, HIS174B, HIS174F, HIS215B, HIS215F, ILE129B, LEU127B, LEU127F, LEU157B, LEU157F, LEU210B, LEU214B, LEU219B, LEU219F, LYS137F, LYS151F, LYS158B, LYS158F, LYS164B, LYS164F, LYS168B, LYS168F, LYS173B, LYS173F, LYS182F, LYS218B, LYS218F, LYS257B, MET162B, MET162F, MET177B, MET177F, MET213B, MET213F, MET261B, PHE156B, PHE156F, PHE165B, PHE165F, PHE175B, PHE175F, PHE178B, PHE178F, PRO141F, PRO389B, PRO389F, SER154F, SER172B, SER172F, SER184B, SER184F, THR128B, THR171B, THR171F, THR212B, THR212F, TYR176B, TYR176F, TYR189B, TYR189F, VAL142F, VAL153F, VAL167F, VAL185B, VAL185F, VAL187B, VAL187F, VAL211B, VAL259B
• C-D: ALA201C, ALA201D, ALA490C, ALA490D, ALA500C, ALA500D, ALA535C, ALA535D, ALA553C, ALA553D, ARG205C, ARG205D, ARG534C, ASN531C, ASN531D, ASN538C, ASN538D, ASP202C, ASP202D, GLU200C, GLU200D, GLU507C, GLU507D, GLU532C, GLU532D, GLY489C, GLY489D, GLY496C, GLY496D, GLY578C, ILE510C, ILE510D, ILE529C, ILE529D, ILE530C, ILE530D, ILE556C, ILE556D, LEU169D, LEU208D, LEU492C, LEU492D, LEU495C, LEU495D, LEU514C, LEU514D, LEU527C, LEU527D, LYS168C, LYS168D, LYS204C, LYS204D, LYS518D, LYS552C, LYS552D, LYS584D, LYS589C, LYS589D, MET491C, MET491D, PHE503C, PHE503D, PHE583C, PRO523C, PRO523D, PRO528C, PRO528D, SER199C, SER199D, SER494C, SER494D, SER498C, SER498D, SER550D, SER554C, SER554D, SER555C, SER555D, THR488C, THR488D, THR497C, THR497D, THR536C, TRP525C, TRP525D, TRP526C, TRP526D, TYR493C, TYR493D, TYR499C, TYR499D, TYR533C, TYR533D, VAL195D, VAL502C, VAL502D, VAL524C, VAL524D, VAL551D, VAL557C, VAL557D, VAL579C, VAL579D
• C-E: ALA186C, ALA186E, ASN139E, ASN161C, ASN161E, ASN166C, ASN166E, ASN183C, ASN183E, ASN217C, ASN217E, ASN258C, ASN260C, ASP216C, ASP216E, ASP256C, GLN152C, GLN152E, GLU138E, GLU155C, GLU155E, GLU160C, GLU160E, GLU163E, GLU262C, GLY126C, GLY140E, GLY188C, HIS174C, HIS174E, HIS215C, HIS215E, ILE129C, LEU127C, LEU157C, LEU157E, LEU214C, LEU219C, LEU219E, LYS151E, LYS158C, LYS158E, LYS164C, LYS164E, LYS168C, LYS168E, LYS173C, LYS173E, LYS182E, LYS218C, LYS218E, LYS257C, MET162C, MET162E, MET177C, MET177E, MET213C, MET213E, MET261C, PHE156C, PHE156E, PHE165C, PHE165E, PHE175C, PHE175E, PHE178C, PHE178E, PRO141E, PRO389C, PRO389E, SER154E, SER172C, SER172E, SER184C, SER184E, SER220C, THR171C, THR171E, THR212C, THR212E, TYR176C, TYR176E, TYR189C, TYR189E, VAL142E, VAL153E, VAL167E, VAL185C, VAL185E, VAL187C, VAL187E, VAL211C, VAL259C
• D-E: ALA299E, ALA300E, ALA340D, ALA387D, ALA387E, ALA388D, ALA388E, ALA447D, ALA535D, ALA542D, ALA585E, ARG251E, ARG440D, ARG586E, ASN303E, ASN306E, ASN352D, ASN384D, ASN432E, ASN437D, ASN437E, ASN449D, ASN457D, ASN538D, ASN545D, ASN582E, ASP249E, ASP379E, ASP394E, ASP443D, ASP468D, ASP543D, ASP95E, CYS305E, GLN296E, GLN90E, GLU245E, GLU250E, GLU334D, GLU335D, GLU431E, GLU454D, GLY339D, GLY345D, GLY345E, GLY347D, GLY347E, GLY381E, GLY382D, GLY382E, GLY442D, GLY450D, GLY456D, HIS215E, ILE298E, ILE393E, ILE444D, ILE445D, ILE453D, ILE544D, ILE547D, LEU333D, LEU336D, LEU342D, LEU385D, LEU385E, LEU395E, LEU537D, LEU94E, LYS253E, LYS331D, LYS337D, LYS346D, LYS346E, LYS386D, LYS386E, LYS397E, LYS436D, LYS436E, LYS451D, LYS540D, LYS584E, LYS587E, MET247E, MET338D, MET349D, MET349E, MET392E, MET396E, MET433E, PHE252E, PHE378E, PHE398E, PRO301E, PRO307E, PRO389D, PRO389E, PRO441D, PRO588E, PRO89E, PRO96E, SER254E, SER295E, SER302E, SER343D, SER348D, SER348E, SER380E, SER391E, SER435D, SER435E, SER438D, SER438E, SER448D, SER539D, SER549D, SER93E, THR248E, THR377E, THR446D, THR452D, THR458D, THR536D, TRP581E, TYR244E, TYR292E, TYR304E, TYR341D, TYR350E, TYR383D, TYR383E, TYR439D, TYR541D, VAL330D, VAL434D, VAL434E, VAL455D, VAL91D, VAL91E, VAL92E
• D-F: ALA299D, ALA300D, ALA340F, ALA387D, ALA387F, ALA388D, ALA388F, ALA447F, ALA535F, ALA542F, ALA585D, ARG251D, ARG440F, ARG586D, ASN303D, ASN306D, ASN352F, ASN384F, ASN432D, ASN437D, ASN437F, ASN449F, ASN457F, ASN538F, ASN545F, ASN582D, ASP249D, ASP379D, ASP394D, ASP443F, ASP468F, ASP543F, ASP95D, CYS305D, GLN296D, GLN90D, GLU245D, GLU250D, GLU332F, GLU334F, GLU335F, GLU431D, GLU454F, GLY339F, GLY345D, GLY345F, GLY347D, GLY347F, GLY381D, GLY382D, GLY382F, GLY442F, GLY450F, GLY456F, HIS215D, ILE298D, ILE393D, ILE444F, ILE445F, ILE453F, ILE544F, ILE547F, LEU333F, LEU336F, LEU342F, LEU385D, LEU385F, LEU395D, LEU537F, LEU94D, LYS253D, LYS331F, LYS337F, LYS346D, LYS346F, LYS386D, LYS386F, LYS397D, LYS436D, LYS436F, LYS451F, LYS540F, LYS584D, LYS587D, MET247D, MET338F, MET349D, MET349F, MET392D, MET396D, MET433D, PHE252D, PHE378D, PHE398D, PRO301D, PRO307D, PRO389D, PRO389F, PRO441F, PRO588D, PRO89D, PRO96D, SER254D, SER295D, SER302D, SER343F, SER348D, SER348F, SER380D, SER391D, SER435D, SER435F, SER438D, SER438F, SER448F, SER539F, SER549F, SER93D, THR248D, THR377D, THR446F, THR452F, THR458F, THR536F, TRP581D, TYR244D, TYR292D, TYR304D, TYR341F, TYR350D, TYR383D, TYR383F, TYR439F, TYR541F, VAL211D, VAL330F, VAL434D, VAL434F, VAL455F, VAL91D, VAL91F, VAL92D
• E-F: ALA299F, ALA300F, ALA340E, ALA387E, ALA387F, ALA388E, ALA388F, ALA447E, ALA535E, ALA542E, ALA585F, ARG251F, ARG440E, ARG586F, ASN303F, ASN306F, ASN352E, ASN384E, ASN432F, ASN437E, ASN437F, ASN449E, ASN457E, ASN538E, ASN545E, ASN582F, ASP249F, ASP379F, ASP394F, ASP443E, ASP468E, ASP543E, ASP95F, CYS305F, GLN296F, GLN90F, GLU245F, GLU250F, GLU334E, GLU335E, GLU431F, GLU454E, GLY339E, GLY345E, GLY345F, GLY347E, GLY347F, GLY381F, GLY382E, GLY382F, GLY442E, GLY450E, GLY456E, HIS215F, ILE298F, ILE393F, ILE444E, ILE445E, ILE453E, ILE544E, ILE547E, LEU333E, LEU336E, LEU342E, LEU385E, LEU385F, LEU395F, LEU537E, LEU94F, LYS253F, LYS331E, LYS337E, LYS346E, LYS346F, LYS386E, LYS386F, LYS397F, LYS436E, LYS436F, LYS451E, LYS540E, LYS584F, LYS587F, MET247F, MET338E, MET349E, MET349F, MET392F, MET396F, MET433F, PHE252F, PHE378F, PHE398F, PRO301F, PRO307F, PRO389E, PRO389F, PRO441E, PRO588F, PRO89F, PRO96F, SER254F, SER295F, SER302F, SER343E, SER348E, SER348F, SER380F, SER391F, SER435E, SER435F, SER438E, SER438F, SER448E, SER539E, SER549E, SER93F, THR248F, THR377F, THR446E, THR452E, THR458E, THR536E, TRP581F, TYR244F, TYR292F, TYR304F, TYR341E, TYR350F, TYR383E, TYR383F, TYR439E, TYR541E, VAL330E, VAL434E, VAL434F, VAL455E, VAL91E, VAL91F, VAL92F
• F-I: ASN181I, ASN183I, ASP180I, ASP364F, GLU125I, GLU262I, GLU324F, GLY363F, HIS266I, HIS356F, HIS424F, ILE264I, LEU219I, LYS182I, LYS218I, LYS221I, LYS265I, LYS326F, LYS360F, LYS362F, LYS366F, LYS368F, MET261I, SER184I, SER220I, THR358F, TYR263I, TYR325F, TYR472F, VAL365F
• F-K: ASN161K, ASN322F, ASP159K, GLU160K, GLU163K, GLU324F, GLY363F, LEU323F, LYS158K, LYS164K, LYS360F, LYS362F, LYS417F, PRO141K, SER361F, TYR359F
• G-H: ALA299H, ALA300H, ALA340G, ALA387G, ALA387H, ALA388G, ALA388H, ALA447G, ALA535G, ALA542G, ALA585H, ARG251H, ARG440G, ARG534G, ARG586H, ASN303H, ASN306H, ASN352G, ASN384G, ASN432H, ASN437G, ASN437H, ASN449G, ASN457G, ASN538G, ASN545G, ASN582H, ASP249H, ASP256H, ASP379H, ASP394H, ASP443G, ASP468G, ASP543G, ASP95H, CYS305H, GLN296H, GLN90H, GLU245H, GLU250H, GLU332G, GLU334G, GLU335G, GLU431H, GLU454G, GLU564G, GLY339G, GLY345G, GLY345H, GLY347G, GLY347H, GLY381H, GLY382G, GLY382H, GLY442G, GLY450G, GLY456G, HIS215H, ILE298H, ILE393H, ILE444G, ILE445G, ILE453G, ILE544G, ILE547G, LEU333G, LEU336G, LEU342G, LEU385G, LEU385H, LEU395H, LEU537G, LEU94H, LYS253H, LYS257H, LYS331G, LYS337G, LYS346G, LYS346H, LYS386G, LYS386H, LYS397H, LYS436G, LYS436H, LYS451G, LYS540G, LYS584H, LYS587H, MET247H, MET338G, MET349G, MET349H, MET392H, MET396H, MET433H, PHE252H, PHE378H, PHE398H, PHE565G, PRO301H, PRO307H, PRO389G, PRO389H, PRO441G, PRO588H, PRO89H, PRO96H, SER254H, SER295H, SER302H, SER343G, SER348G, SER348H, SER380H, SER391H, SER435G, SER435H, SER438G, SER438H, SER448G, SER539G, SER549G, SER93H, THR248H, THR255H, THR377H, THR446G, THR452G, THR458G, THR536G, TRP581H, TYR244H, TYR292H, TYR304H, TYR341G, TYR350H, TYR383G, TYR383H, TYR439G, TYR541G, VAL330G, VAL434G, VAL434H, VAL455G, VAL91G, VAL91H, VAL92H
• G-I: ALA299G, ALA300G, ALA340I, ALA387G, ALA387I, ALA388G, ALA388I, ALA447I, ALA535I, ALA542I, ALA585G, ARG251G, ARG440I, ARG534I, ARG586G, ASN303G, ASN306G, ASN352I, ASN384I, ASN432G, ASN437G, ASN437I, ASN449I, ASN457I, ASN538I, ASN545I, ASN582G, ASP249G, ASP256G, ASP379G, ASP394G, ASP443I, ASP468I, ASP543I, ASP95G, CYS305G, GLN296G, GLN90G, GLU245G, GLU250G, GLU332I, GLU334I, GLU335I, GLU431G, GLU454I, GLU564I, GLY339I, GLY345G, GLY345I, GLY347G, GLY347I, GLY381G, GLY382G, GLY382I, GLY442I, GLY450I, GLY456I, HIS215G, ILE298G, ILE393G, ILE444I, ILE445I, ILE453I, ILE544I, ILE547I, LEU333I, LEU336I, LEU342I, LEU385G, LEU385I, LEU395G, LEU537I, LEU94G, LYS253G, LYS257G, LYS331I, LYS337I, LYS346G, LYS346I, LYS386G, LYS386I, LYS397G, LYS436G, LYS436I, LYS451I, LYS540I, LYS584G, LYS587G, MET247G, MET338I, MET349G, MET349I, MET392G, MET396G, MET433G, PHE252G, PHE378G, PHE398G, PHE565I, PRO301G, PRO307G, PRO351I, PRO389G, PRO389I, PRO441I, PRO588G, PRO89G, PRO96G, SER254G, SER295G, SER302G, SER343I, SER348G, SER348I, SER380G, SER391G, SER435G, SER435I, SER438G, SER438I, SER448I, SER539I, SER549I, SER93G, THR248G, THR255G, THR377G, THR446I, THR452I, THR458I, THR536I, TRP581G, TYR244G, TYR292G, TYR304G, TYR341I, TYR350G, TYR383G, TYR383I, TYR439I, TYR541I, VAL330I, VAL434G, VAL434I, VAL455I, VAL91G, VAL91I, VAL92G
• G-J: ALA186G, ALA186J, ASN139G, ASN139J, ASN161G, ASN161J, ASN166G, ASN166J, ASN179J, ASN183G, ASN217G, ASN217J, ASN258G, ASN260G, ASN260J, ASP216G, ASP216J, ASP256G, GLN152G, GLN152J, GLU138J, GLU155G, GLU155J, GLU160G, GLU160J, GLU163G, GLU163J, GLU262G, GLY126G, GLY140G, GLY140J, GLY170G, GLY188G, HIS174G, HIS174J, HIS215G, HIS215J, ILE129G, LEU127G, LEU127J, LEU157G, LEU157J, LEU214G, LEU214J, LEU219G, LEU219J, LYS137J, LYS151J, LYS158G, LYS158J, LYS164G, LYS164J, LYS168G, LYS168J, LYS173G, LYS173J, LYS182G, LYS218G, LYS218J, LYS257G, MET162G, MET162J, MET177G, MET177J, MET213G, MET213J, MET261G, MET261J, PHE156G, PHE156J, PHE165G, PHE165J, PHE175G, PHE175J, PHE178G, PHE178J, PRO141G, PRO141J, PRO389G, PRO389J, SER154J, SER172G, SER172J, SER184G, SER184J, SER220G, THR128G, THR171G, THR171J, THR212G, THR212J, TYR176G, TYR176J, TYR189G, TYR189J, VAL142G, VAL153J, VAL167J, VAL185G, VAL185J, VAL187G, VAL187J, VAL211G
• G-L: ALA201G, ALA201L, ALA490G, ALA490L, ALA500G, ALA500L, ALA535G, ALA535L, ALA553G, ALA553L, ARG205G, ARG205L, ASN531G, ASN531L, ASN538G, ASN538L, ASP202G, ASP202L, GLU200G, GLU200L, GLU507G, GLU507L, GLU532G, GLU532L, GLY489G, GLY489L, GLY496G, GLY496L, GLY504G, GLY578G, ILE510G, ILE510L, ILE529G, ILE529L, ILE530G, ILE530L, ILE556G, ILE556L, LEU169L, LEU208G, LEU208L, LEU492G, LEU492L, LEU495G, LEU495L, LEU514G, LEU514L, LEU527G, LEU527L, LYS168G, LYS168L, LYS204G, LYS204L, LYS552G, LYS552L, LYS584G, LYS584L, LYS589G, LYS589L, MET491G, MET491L, PHE503G, PHE503L, PHE583L, PRO523G, PRO523L, PRO528G, PRO528L, SER199G, SER199L, SER494G, SER494L, SER498G, SER498L, SER550G, SER550L, SER554G, SER554L, SER555G, SER555L, THR488G, THR488L, THR497G, THR497L, THR536G, THR536L, TRP525G, TRP525L, TRP526G, TRP526L, TYR493G, TYR493L, TYR499G, TYR499L, TYR533G, TYR533L, VAL195L, VAL502G, VAL502L, VAL524G, VAL524L, VAL551L, VAL557G, VAL557L, VAL579G, VAL579L
• H-I: ALA299I, ALA300I, ALA340H, ALA387H, ALA387I, ALA388H, ALA388I, ALA447H, ALA535H, ALA542H, ALA585I, ARG251I, ARG440H, ARG534H, ARG586I, ASN303I, ASN306I, ASN352H, ASN384H, ASN432I, ASN437H, ASN437I, ASN449H, ASN457H, ASN538H, ASN545H, ASN582I, ASP249I, ASP256I, ASP379I, ASP394I, ASP443H, ASP468H, ASP543H, ASP95I, CYS305I, GLN296I, GLN90I, GLU245I, GLU250I, GLU332H, GLU334H, GLU335H, GLU431I, GLU454H, GLY339H, GLY345H, GLY345I, GLY347H, GLY347I, GLY381I, GLY382H, GLY382I, GLY442H, GLY450H, GLY456H, HIS215I, ILE298I, ILE393I, ILE444H, ILE445H, ILE453H, ILE544H, ILE547H, LEU333H, LEU336H, LEU342H, LEU385H, LEU385I, LEU395I, LEU537H, LEU94I, LYS253I, LYS257I, LYS331H, LYS337H, LYS346H, LYS346I, LYS386H, LYS386I, LYS397I, LYS436H, LYS436I, LYS451H, LYS540H, LYS584I, LYS587I, MET247I, MET338H, MET349I, MET392I, MET396I, MET433I, PHE252I, PHE378I, PHE398I, PRO301I, PRO307I, PRO351H, PRO389H, PRO389I, PRO441H, PRO588I, PRO89I, PRO96I, SER254I, SER295I, SER302I, SER343H, SER348H, SER348I, SER380I, SER391I, SER435H, SER435I, SER438H, SER438I, SER448H, SER539H, SER549H, SER93I, THR248I, THR255I, THR377I, THR446H, THR452H, THR458H, THR536H, TRP581I, TYR244I, TYR292I, TYR304I, TYR341H, TYR350I, TYR383H, TYR383I, TYR439H, TYR541H, VAL330H, VAL434H, VAL434I, VAL455H, VAL91H, VAL91I, VAL92I
• H-K: ALA201H, ALA201K, ALA490H, ALA490K, ALA500H, ALA500K, ALA535H, ALA535K, ALA553H, ALA553K, ARG205H, ARG205K, ASN531H, ASN531K, ASN538H, ASN538K, ASP202H, ASP202K, GLU200H, GLU200K, GLU507H, GLU507K, GLU532H, GLU532K, GLY489H, GLY489K, GLY496H, GLY496K, GLY578H, GLY578K, ILE510H, ILE510K, ILE529H, ILE529K, ILE530H, ILE530K, ILE556H, ILE556K, LEU169K, LEU208K, LEU395H, LEU492H, LEU492K, LEU495H, LEU495K, LEU514H, LEU514K, LEU527H, LEU527K, LYS168K, LYS204H, LYS204K, LYS518K, LYS552H, LYS552K, LYS584H, LYS589H, LYS589K, MET392H, MET491H, MET491K, PHE503H, PHE503K, PHE583H, PRO523H, PRO523K, PRO528H, PRO528K, SER199H, SER199K, SER494H, SER494K, SER498H, SER498K, SER550H, SER550K, SER554H, SER554K, SER555H, SER555K, THR488H, THR488K, THR497H, THR497K, THR536H, THR536K, TRP525H, TRP525K, TRP526H, TRP526K, TRP581H, TYR493H, TYR493K, TYR499H, TYR499K, TYR533H, TYR533K, VAL195K, VAL502H, VAL502K, VAL524H, VAL524K, VAL551H, VAL551K, VAL557H, VAL557K, VAL579H, VAL579K
• H-L: ALA186H, ALA186L, ASN139L, ASN161H, ASN161L, ASN166H, ASN166L, ASN183L, ASN217H, ASN217L, ASN258H, ASN260H, ASP216H, ASP216L, ASP256H, GLN152H, GLN152L, GLU138L, GLU155H, GLU155L, GLU160H, GLU163L, GLU262H, GLY126H, GLY126L, GLY140L, GLY188H, HIS174H, HIS174L, HIS215H, HIS215L, ILE129H, LEU127H, LEU157H, LEU157L, LEU219H, LEU219L, LYS137L, LYS151L, LYS158H, LYS158L, LYS164H, LYS164L, LYS168H, LYS168L, LYS173H, LYS173L, LYS182L, LYS218H, LYS218L, LYS257H, MET162H, MET162L, MET177H, MET177L, MET213H, MET213L, MET261H, PHE156H, PHE156L, PHE165H, PHE165L, PHE175H, PHE175L, PHE178H, PHE178L, PRO141L, PRO389H, PRO389L, SER154L, SER172H, SER172L, SER184H, SER184L, THR128H, THR171H, THR171L, THR212H, THR212L, TYR176H, TYR176L, TYR189H, TYR189L, VAL153L, VAL167L, VAL185H, VAL185L, VAL187H, VAL187L, VAL259H
• I-J: ALA201I, ALA201J, ALA490I, ALA490J, ALA500I, ALA500J, ALA535I, ALA535J, ALA553I, ALA553J, ARG205I, ARG205J, ARG534I, ASN531I, ASN531J, ASN538I, ASN538J, ASP202I, ASP202J, GLU200I, GLU200J, GLU507I, GLU507J, GLU532I, GLU532J, GLY489I, GLY489J, GLY496I, GLY496J, GLY578I, ILE510I, ILE510J, ILE529I, ILE529J, ILE530I, ILE530J, ILE556I, ILE556J, LEU169J, LEU208J, LEU492I, LEU492J, LEU495I, LEU495J, LEU514I, LEU514J, LEU527I, LEU527J, LYS168I, LYS168J, LYS204I, LYS204J, LYS518J, LYS552I, LYS552J, LYS584J, LYS589I, LYS589J, MET491I, MET491J, PHE503I, PHE503J, PHE583I, PHE583J, PRO523I, PRO523J, PRO528I, PRO528J, SER199I, SER199J, SER494I, SER494J, SER498I, SER498J, SER550I, SER550J, SER554I, SER554J, SER555I, SER555J, THR488I, THR488J, THR497I, THR497J, THR536I, TRP525I, TRP525J, TRP526I, TRP526J, TYR493I, TYR493J, TYR499I, TYR499J, TYR533I, TYR533J, VAL195J, VAL502I, VAL502J, VAL524I, VAL524J, VAL551I, VAL551J, VAL557I, VAL557J, VAL579I, VAL579J
• I-K: ALA186I, ALA186K, ASN139K, ASN161I, ASN161K, ASN166I, ASN166K, ASN179K, ASN183K, ASN217I, ASN217K, ASN258I, ASN260I, ASP216I, ASP216K, ASP256I, GLN152I, GLN152K, GLU138K, GLU155I, GLU155K, GLU160I, GLU160K, GLU163K, GLU262I, GLY126I, GLY140K, GLY170I, GLY188I, HIS174I, HIS174K, HIS215I, HIS215K, LEU127I, LEU157I, LEU157K, LEU214I, LEU219I, LEU219K, LYS137K, LYS151K, LYS158I, LYS158K, LYS164I, LYS164K, LYS168I, LYS168K, LYS173I, LYS173K, LYS182I, LYS182K, LYS218I, LYS218K, LYS257I, MET162I, MET162K, MET177I, MET177K, MET213I, MET213K, PHE156I, PHE156K, PHE165I, PHE165K, PHE175I, PHE175K, PHE178I, PHE178K, PRO141K, PRO389I, PRO389K, SER154K, SER172I, SER172K, SER184I, SER184K, THR171I, THR171K, THR212I, THR212K, TYR176I, TYR176K, TYR189I, TYR189K, VAL142K, VAL153K, VAL167K, VAL185I, VAL185K, VAL187I, VAL187K, VAL211I, VAL259I
• J-K: ALA299K, ALA300K, ALA340J, ALA387J, ALA387K, ALA388J, ALA388K, ALA447J, ALA535J, ALA542J, ALA585K, ARG251K, ARG440J, ARG586K, ASN303K, ASN306K, ASN352J, ASN384J, ASN432K, ASN437J, ASN437K, ASN449J, ASN457J, ASN538J, ASN545J, ASN582K, ASP249K, ASP379K, ASP394K, ASP443J, ASP468J, ASP543J, ASP95K, CYS305K, GLN296K, GLN90K, GLU245K, GLU250K, GLU334J, GLU335J, GLU431K, GLU454J, GLY339J, GLY345J, GLY345K, GLY347J, GLY347K, GLY381K, GLY382J, GLY382K, GLY442J, GLY450J, GLY456J, HIS215K, ILE298K, ILE393K, ILE444J, ILE445J, ILE453J, ILE544J, ILE547J, LEU333J, LEU336J, LEU342J, LEU385J, LEU385K, LEU395K, LEU537J, LEU94K, LYS253K, LYS331J, LYS337J, LYS346J, LYS346K, LYS386J, LYS386K, LYS397K, LYS436J, LYS436K, LYS451J, LYS540J, LYS584K, LYS587K, MET247K, MET338J, MET349J, MET349K, MET392K, MET396K, MET433K, PHE252K, PHE378K, PHE398K, PRO301K, PRO307K, PRO389J, PRO389K, PRO441J, PRO588K, PRO89K, PRO96K, SER254K, SER295K, SER302K, SER343J, SER348J, SER348K, SER380K, SER391K, SER435J, SER435K, SER438J, SER438K, SER448J, SER539J, SER549J, SER93K, THR248K, THR377K, THR446J, THR452J, THR458J, THR536J, TRP581K, TYR244K, TYR292K, TYR304K, TYR341J, TYR350K, TYR383J, TYR383K, TYR439J, TYR541J, VAL211K, VAL330J, VAL434J, VAL434K, VAL455J, VAL91J, VAL91K, VAL92K
• J-L: ALA299J, ALA300J, ALA340L, ALA387J, ALA387L, ALA388J, ALA388L, ALA447L, ALA535L, ALA542L, ALA585J, ARG251J, ARG440L, ARG586J, ASN303J, ASN306J, ASN352L, ASN384L, ASN432J, ASN437J, ASN437L, ASN449L, ASN457L, ASN538L, ASN545L, ASN582J, ASP249J, ASP379J, ASP394J, ASP443L, ASP468L, ASP543L, ASP95J, CYS305J, GLN296J, GLN90J, GLU245J, GLU250J, GLU334L, GLU335L, GLU431J, GLU454L, GLY339L, GLY345J, GLY345L, GLY347J, GLY347L, GLY381J, GLY382J, GLY382L, GLY442L, GLY450L, GLY456L, HIS215J, ILE298J, ILE393J, ILE444L, ILE445L, ILE453L, ILE544L, ILE547L, LEU333L, LEU336L, LEU342L, LEU385J, LEU385L, LEU395J, LEU537L, LEU94J, LYS253J, LYS331L, LYS337L, LYS346J, LYS346L, LYS386J, LYS386L, LYS397J, LYS436J, LYS436L, LYS451L, LYS540L, LYS584J, LYS587J, MET247J, MET338L, MET349J, MET349L, MET392J, MET396J, MET433J, PHE252J, PHE378J, PHE398J, PRO301J, PRO307J, PRO389J, PRO389L, PRO441L, PRO588J, PRO89J, PRO96J, SER254J, SER295J, SER302J, SER343L, SER348J, SER348L, SER380J, SER391J, SER435J, SER435L, SER438J, SER438L, SER448L, SER539L, SER549L, SER93J, THR248J, THR377J, THR446L, THR452L, THR458L, THR536L, TRP581J, TYR244J, TYR292J, TYR304J, TYR341L, TYR350J, TYR383J, TYR383L, TYR439L, TYR541L, VAL330L, VAL434J, VAL434L, VAL455L, VAL91J, VAL91L, VAL92J
• K-L: ALA299L, ALA300L, ALA340K, ALA387K, ALA387L, ALA388K, ALA388L, ALA447K, ALA535K, ALA542K, ALA585L, ARG251L, ARG440K, ARG586L, ASN303L, ASN306L, ASN352K, ASN384K, ASN432L, ASN437K, ASN437L, ASN449K, ASN457K, ASN538K, ASN545K, ASN582L, ASP249L, ASP379L, ASP394L, ASP443K, ASP468K, ASP543K, ASP95L, CYS305L, GLN296L, GLN90L, GLU245L, GLU250L, GLU334K, GLU335K, GLU431L, GLU454K, GLY339K, GLY345K, GLY345L, GLY347K, GLY347L, GLY381L, GLY382K, GLY382L, GLY442K, GLY450K, GLY456K, HIS215L, ILE298L, ILE393L, ILE444K, ILE445K, ILE453K, ILE544K, ILE547K, LEU333K, LEU336K, LEU342K, LEU385K, LEU385L, LEU395L, LEU537K, LEU94L, LYS253L, LYS331K, LYS337K, LYS346K, LYS346L, LYS386K, LYS386L, LYS397L, LYS436K, LYS436L, LYS451K, LYS540K, LYS584L, LYS587L, MET247L, MET338K, MET349K, MET349L, MET392L, MET396L, MET433L, PHE252L, PHE378L, PHE398L, PRO301L, PRO307L, PRO389K, PRO389L, PRO441K, PRO588L, PRO89L, PRO96L, SER254L, SER295L, SER302L, SER343K, SER348K, SER348L, SER380L, SER391L, SER435K, SER435L, SER438K, SER438L, SER448K, SER539K, SER549K, SER93L, THR248L, THR377L, THR446K, THR452K, THR458K, THR536K, TRP581L, TYR244L, TYR292L, TYR304L, TYR341K, TYR350L, TYR383K, TYR383L, TYR439K, TYR541K, VAL330K, VAL434K, VAL434L, VAL455K, VAL91K, VAL91L, VAL92L