3T89

crystal structure of escherichia coli menb, the 1,4-dihydroxy-2- naphthoyl-coa synthase in vitamin k2 biosynthesis

• Total interactions analyzed: 15
• Total true interactions: 15
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 121
  • Norm. En. per Res.: -4.9002
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	0.0	-0.0897	-0.0897	8	0	0	40	0	0	0
A-C	-96.0095	-47.5615	-449.392	-592.963	132	21	8	17345	5	29	29
A-D	-91.0398	-49.719	-409.662	-550.4209	131	18	8	16234	5	28	27
A-E	-59.4268	4.1364	-374.257	-429.5474	162	18	16	15756	0	17	24
A-F	-77.8698	-2.5635	-473.088	-553.5212	169	14	2	16133	8	28	32
B-C	-31.7442	0.0	-250.325	-282.0692	112	4	17	10648	0	11	16
B-D	-50.5097	-7.061	-471.157	-528.7276	168	12	2	16313	4	24	24
B-E	-91.7616	-50.7433	-399.832	-542.3369	124	13	8	15585	5	29	29
B-F	-94.818	-50.9647	-396.678	-542.4606	124	13	9	15688	5	29	28
C-D	-110.6175	-51.1592	-431.151	-592.9276	121	19	9	17267	5	29	28
C-E	-49.8098	20.0539	-485.66	-515.416	163	18	5	16483	8	25	29
C-F	0.0	0.0	-0.069	-0.069	8	0	0	36	0	0	0
D-E	0.0	0.0	-0.0795	-0.0795	8	0	0	39	0	0	0
D-F	-61.9364	4.2425	-374.154	-431.8479	157	10	17	15035	0	19	27
E-F	-97.4273	-50.1336	-407.622	-555.1828	127	13	8	15878	5	26	30

Interface residues

• A-B: ARG173A, ARG173B, ARG181A, ARG181B, GLN177A, GLN177B, GLN243A, GLN243B
• A-C: ALA124A, ALA168C, ALA172A, ALA172C, ALA180C, ALA195A, ALA228A, ALA234A, ALA235A, ALA238A, ALA253A, ARG113C, ARG116A, ARG173A, ARG173C, ARG181C, ARG188C, ARG216A, ARG219A, ARG230A, ASN107C, ASN202A, ASN224A, ASN237A, ASN252A, ASN284A, ASP110C, ASP142A, ASP163C, ASP197A, ASP197C, ASP239A, ASP239C, ASP241A, CYS118A, CYS141A, CYS187C, CYS218A, CYS231A, CYS240A, CYS240C, GLN154C, GLN177C, GLN189C, GLN194C, GLN223A, GLU182C, GLU213A, GLU220A, GLU6A, GLY132C, GLY153C, GLY156C, GLY160C, GLY164C, GLY165C, GLY167C, GLY176A, GLY176C, GLY199A, HIS104C, HIS105C, HIS135A, HIS138A, ILE115A, ILE131C, ILE145A, ILE174A, ILE183C, ILE2A, LEU106C, LEU137A, LEU143A, LEU186C, LEU196A, LEU200A, LEU222A, LEU229A, LEU232A, LEU236A, LEU249A, LEU256A, LEU9A, LYS120A, LYS158C, LYS178C, LYS179C, LYS233A, MET139A, MET140A, MET171A, MET171C, MET198A, MET198C, MET1A, MET221A, MET227A, MET8A, PHE152A, PHE162C, PHE185C, PRO121A, PRO157C, PRO226A, PRO285A, PRO4A, SER161C, SER169A, SER169C, SER225A, THR144A, THR155C, THR203A, THR214A, TRP166C, TRP184C, TRP217A, TYR10A, TYR129C, TYR170A, TYR170C, TYR190C, TYR3A, VAL122A, VAL123A, VAL126A, VAL136A, VAL159C, VAL175A, VAL175C, VAL201A, VAL71A
• A-D: ALA124D, ALA168A, ALA172A, ALA172D, ALA180A, ALA228D, ALA234D, ALA235D, ALA238D, ALA253D, ARG113A, ARG116D, ARG173A, ARG173D, ARG181A, ARG188A, ARG216D, ARG219D, ARG230D, ASN107A, ASN202D, ASN224D, ASN237D, ASN252D, ASN284D, ASP110A, ASP142D, ASP163A, ASP197A, ASP197D, ASP239A, ASP239D, ASP241D, CYS118D, CYS141D, CYS187A, CYS218D, CYS231D, CYS240A, CYS240D, GLN154A, GLN177A, GLN189A, GLN194A, GLN223D, GLU182A, GLU213D, GLU220D, GLY153A, GLY156A, GLY160A, GLY164A, GLY165A, GLY167A, GLY176A, GLY176D, GLY199D, HIS105A, HIS135D, HIS138D, ILE115D, ILE131A, ILE145D, ILE151A, ILE174D, ILE183A, ILE2D, LEU106A, LEU109A, LEU137D, LEU143D, LEU186A, LEU196D, LEU200D, LEU222D, LEU229D, LEU232D, LEU236D, LEU249D, LEU256D, LEU9D, LYS120D, LYS158A, LYS178A, LYS179A, LYS233D, MET139A, MET139D, MET140D, MET171A, MET171D, MET198A, MET198D, MET221D, MET227D, MET8D, PHE152A, PHE152D, PHE162A, PHE185A, PRO121D, PRO157A, PRO226D, PRO285D, PRO4D, SER161A, SER169A, SER169D, SER225D, THR144D, THR155A, THR203D, THR214D, TRP166A, TRP184A, TRP217D, TYR10D, TYR129A, TYR170A, TYR170D, TYR190A, TYR3D, VAL122D, VAL123D, VAL126D, VAL136D, VAL159A, VAL175A, VAL175D, VAL201D, VAL71D
• A-E: ALA228A, ALA228E, ALA234A, ALA234E, ALA235A, ALA235E, ALA238A, ALA238E, ALA250A, ALA250E, ALA253A, ALA253E, ALA269E, ALA61A, ALA61E, ALA63A, ALA63E, ARG173A, ARG173E, ARG219E, ARG230A, ARG230E, ARG274E, ARG283A, ARG283E, ARG64A, ARG64E, ASN224A, ASN224E, ASN237A, ASN237E, ASN252A, ASN252E, ASN284A, ASN284E, ASN68A, ASN68E, ASP239A, ASP239E, ASP241A, ASP241E, ASP277A, ASP277E, ASP32A, ASP32E, ASP5A, ASP62A, ASP62E, ASP66A, ASP66E, ASP67A, ASP67E, CYS118A, CYS118E, CYS218E, CYS231A, CYS231E, CYS240A, CYS240E, GLN223A, GLN223E, GLN243A, GLN243E, GLN247A, GLN247E, GLN264A, GLN264E, GLN275A, GLN275E, GLU248A, GLU248E, GLU261A, GLU261E, GLU262A, GLU262E, GLU265A, GLU265E, GLY242A, GLY242E, GLY245A, GLY245E, GLY251A, GLY251E, GLY263A, GLY263E, GLY266A, GLY266E, GLY33A, GLY33E, GLY70A, GLY70E, ILE2A, ILE2E, ILE69A, ILE69E, LEU222A, LEU222E, LEU229A, LEU229E, LEU232A, LEU232E, LEU236A, LEU236E, LEU246A, LEU246E, LEU249A, LEU249E, LEU256A, LEU256E, LYS120A, LYS120E, LYS273E, LYS280A, LYS280E, LYS282A, LYS282E, MET1A, MET221A, MET221E, MET227A, MET227E, MET255A, MET255E, MET259A, MET259E, MET8A, PHE257A, PHE257E, PHE270E, PHE278A, PHE278E, PHE281A, PHE281E, PRO119A, PRO119E, PRO121A, PRO121E, PRO226A, PRO226E, PRO276A, PRO276E, PRO285A, PRO285E, PRO4A, SER225A, SER225E, SER279A, SER279E, THR117A, THR117E, THR254A, THR254E, THR260A, THR260E, TYR258A, TYR258E, TYR3A, TYR3E, TYR65A, TYR65E, VAL71A, VAL71E
• A-F: ALA168A, ALA168F, ALA172A, ALA172F, ALA234A, ALA234F, ALA238A, ALA238F, ALA244A, ALA244F, ALA250A, ALA250F, ALA253A, ALA253F, ALA269A, ALA269F, ARG113A, ARG113F, ARG116A, ARG116F, ARG173A, ARG173F, ARG230A, ARG230F, ARG267A, ARG267F, ARG274F, ARG64A, ARG64F, ASN107A, ASN107F, ASN237A, ASN237F, ASN252A, ASN252F, ASN268A, ASN268F, ASP110A, ASP110F, ASP163A, ASP163F, ASP239A, ASP239F, ASP241A, ASP241F, ASP277A, ASP87F, CYS118A, CYS118F, CYS240A, CYS240F, GLN112A, GLN112F, GLN114A, GLN114F, GLN177A, GLN177F, GLN243A, GLN243F, GLN247A, GLN247F, GLN264A, GLN264F, GLN275A, GLN275F, GLN88A, GLU248A, GLU248F, GLU261A, GLU261F, GLU262A, GLU262F, GLU265A, GLU265F, GLY156A, GLY156F, GLY160A, GLY160F, GLY164A, GLY164F, GLY165A, GLY165F, GLY167A, GLY167F, GLY242A, GLY242F, GLY245A, GLY245F, GLY251A, GLY251F, GLY263A, GLY263F, GLY266A, GLY266F, GLY86A, GLY86F, HIS104F, HIS105A, HIS105F, ILE115A, ILE115F, ILE174A, ILE174F, ILE57A, ILE57F, LEU106A, LEU106F, LEU109A, LEU109F, LEU246A, LEU246F, LEU249A, LEU249F, LEU256A, LEU256F, LYS158A, LYS158F, LYS54F, MET140A, MET140F, MET171A, MET171F, MET255A, MET255F, PHE111A, PHE111F, PHE162A, PHE162F, PHE257A, PHE257F, PHE270A, PHE278A, PHE278F, PHE281A, PRO119A, PRO119F, PRO157A, PRO157F, PRO276A, PRO276F, SER161A, SER161F, SER169A, SER169F, THR117A, THR117F, THR155A, THR155F, THR254A, THR254F, THR260A, THR260F, TRP166A, TRP166F, TRP184F, TYR170A, TYR170F, TYR258A, TYR258F, TYR65A, TYR65F, VAL103F, VAL108A, VAL108F, VAL136A, VAL136F, VAL159A, VAL159F, VAL44F
• B-C: ALA228B, ALA228C, ALA234B, ALA234C, ALA235B, ALA235C, ALA238B, ALA238C, ALA250B, ALA250C, ALA253B, ALA253C, ALA61C, ALA63C, ARG173B, ARG173C, ARG230C, ARG283B, ARG64C, ASN224C, ASN237B, ASN237C, ASN252B, ASN252C, ASN284B, ASN68C, ASP239B, ASP239C, ASP241B, ASP241C, ASP277B, ASP32C, ASP62C, ASP66C, ASP67C, CYS118C, CYS231B, CYS231C, CYS240B, CYS240C, GLN223C, GLN243B, GLN243C, GLN247B, GLN247C, GLN275B, GLU248B, GLU248C, GLU261B, GLU261C, GLU262B, GLU262C, GLU265B, GLY242B, GLY242C, GLY245B, GLY245C, GLY251B, GLY251C, GLY263B, GLY263C, GLY266B, GLY33C, GLY70C, ILE69C, LEU222C, LEU229B, LEU229C, LEU232B, LEU232C, LEU236B, LEU236C, LEU246B, LEU246C, LEU249B, LEU249C, LEU256B, LEU256C, LYS120C, LYS280B, LYS282B, MET221C, MET227B, MET227C, MET255B, MET255C, MET259B, MET259C, PHE257B, PHE257C, PHE278B, PHE281B, PRO119C, PRO121C, PRO226B, PRO226C, PRO276B, PRO285B, PRO4C, SER225B, SER225C, SER279B, THR117C, THR254B, THR254C, THR260B, THR260C, TYR258B, TYR258C, TYR3C, TYR65C, VAL71C
• B-D: ALA168B, ALA168D, ALA172B, ALA172D, ALA234D, ALA238B, ALA238D, ALA244B, ALA244D, ALA250B, ALA250D, ALA253B, ALA253D, ALA269B, ALA269D, ARG113B, ARG113D, ARG116B, ARG116D, ARG173B, ARG173D, ARG230B, ARG230D, ARG267B, ARG267D, ARG274D, ARG64B, ARG64D, ASN107B, ASN107D, ASN237B, ASN237D, ASN252B, ASN252D, ASN268B, ASN268D, ASN271D, ASP110B, ASP110D, ASP163B, ASP163D, ASP239B, ASP239D, ASP241B, ASP241D, ASP277B, ASP67B, ASP87B, CYS118D, CYS240B, CYS240D, GLN112B, GLN112D, GLN114B, GLN114D, GLN177B, GLN177D, GLN243B, GLN243D, GLN247B, GLN247D, GLN264B, GLN264D, GLN275B, GLN275D, GLN88B, GLN88D, GLU248B, GLU248D, GLU261B, GLU261D, GLU262B, GLU262D, GLU265B, GLU265D, GLY156B, GLY156D, GLY160B, GLY160D, GLY164B, GLY164D, GLY165B, GLY165D, GLY167B, GLY167D, GLY242B, GLY242D, GLY245B, GLY245D, GLY251B, GLY251D, GLY263B, GLY263D, GLY266B, GLY266D, GLY86B, GLY86D, HIS105D, ILE115B, ILE115D, ILE174B, ILE174D, ILE57B, ILE57D, LEU106B, LEU106D, LEU109B, LEU109D, LEU246B, LEU246D, LEU249B, LEU249D, LEU256B, LEU256D, LYS158B, LYS158D, LYS54B, LYS89B, MET140B, MET140D, MET171B, MET171D, MET227D, MET255B, MET255D, MET259B, MET259D, PHE111B, PHE111D, PHE162B, PHE162D, PHE257B, PHE257D, PHE270B, PHE270D, PHE278B, PHE278D, PRO119B, PRO119D, PRO157B, PRO157D, PRO276B, PRO276D, SER161B, SER161D, SER169B, SER169D, THR117B, THR117D, THR155B, THR155D, THR254B, THR254D, TRP166B, TRP166D, TYR170B, TYR170D, TYR258B, TYR258D, TYR65B, TYR65D, VAL108B, VAL108D, VAL136B, VAL136D, VAL159B, VAL159D, VAL90B
• B-E: ALA124B, ALA168E, ALA172B, ALA172E, ALA180E, ALA228B, ALA234B, ALA235B, ALA238B, ALA253B, ARG113E, ARG116B, ARG173B, ARG173E, ARG181E, ARG188E, ARG216B, ARG219B, ARG230B, ASN107E, ASN202B, ASN224B, ASN237B, ASN252B, ASN284B, ASP110E, ASP142B, ASP163E, ASP197B, ASP197E, ASP239B, ASP239E, ASP241B, CYS118B, CYS141B, CYS187E, CYS218B, CYS231B, CYS240B, CYS240E, GLN154E, GLN177E, GLN189E, GLN223B, GLU182E, GLU213B, GLU220B, GLY156E, GLY160E, GLY164E, GLY165E, GLY167E, GLY176B, GLY176E, GLY199B, HIS104E, HIS105E, HIS135B, HIS138B, ILE115B, ILE145B, ILE174B, ILE183E, LEU106E, LEU109E, LEU137B, LEU143B, LEU186E, LEU196B, LEU200B, LEU222B, LEU229B, LEU232B, LEU236B, LEU249B, LEU256B, LEU9B, LYS120B, LYS158E, LYS178E, LYS179E, LYS233B, MET139B, MET140B, MET171B, MET171E, MET198B, MET198E, MET221B, MET227B, MET8B, PHE152B, PHE162E, PHE185E, PRO121B, PRO157E, PRO226B, PRO285B, PRO4B, SER161E, SER169B, SER169E, SER225B, THR144B, THR155E, THR203B, THR214B, TRP166E, TRP184E, TRP217B, TYR10B, TYR170B, TYR170E, TYR190E, VAL103E, VAL122B, VAL123B, VAL126B, VAL136B, VAL159E, VAL175B, VAL175E, VAL201B, VAL71B
• B-F: ALA124F, ALA168B, ALA172B, ALA172F, ALA180B, ALA195F, ALA228F, ALA234F, ALA235F, ALA238F, ALA253F, ARG113B, ARG116F, ARG173B, ARG173F, ARG181B, ARG188B, ARG216F, ARG219F, ARG230F, ASN107B, ASN202F, ASN224F, ASN237F, ASN252F, ASN284F, ASP110B, ASP142F, ASP163B, ASP197B, ASP197F, ASP239B, ASP239F, ASP241F, CYS118F, CYS141F, CYS187B, CYS218F, CYS231F, CYS240B, CYS240F, GLN154B, GLN177B, GLN189B, GLN223F, GLU182B, GLU213F, GLU220F, GLY156B, GLY160B, GLY164B, GLY165B, GLY167B, GLY176B, GLY176F, GLY199F, HIS135F, HIS138F, ILE115F, ILE145F, ILE174F, ILE183B, LEU106B, LEU109B, LEU137F, LEU143F, LEU186B, LEU196F, LEU200F, LEU222F, LEU229F, LEU232F, LEU236F, LEU249F, LEU256F, LEU9F, LYS120F, LYS158B, LYS178B, LYS179B, LYS233F, MET139F, MET140F, MET171B, MET171F, MET198B, MET198F, MET221F, MET227F, MET8F, PHE152F, PHE162B, PHE185B, PRO119F, PRO121F, PRO157B, PRO226F, PRO285F, PRO4F, SER161B, SER169B, SER169F, SER225F, THR144F, THR155B, THR203F, THR214F, TRP166B, TRP184B, TRP217F, TYR10F, TYR170B, TYR170F, TYR190B, TYR3F, VAL122F, VAL123F, VAL126F, VAL136F, VAL159B, VAL175B, VAL175F, VAL201F, VAL71F
• C-D: ALA124C, ALA168D, ALA172C, ALA172D, ALA180D, ALA228C, ALA234C, ALA235C, ALA238C, ALA253C, ARG116C, ARG173C, ARG173D, ARG181D, ARG188D, ARG216C, ARG219C, ARG230C, ASN202C, ASN224C, ASN237C, ASN252C, ASP142C, ASP163D, ASP197C, ASP197D, ASP239C, ASP239D, ASP241C, CYS118C, CYS141C, CYS187D, CYS218C, CYS231C, CYS240C, CYS240D, GLN154D, GLN177D, GLN189D, GLN194D, GLN223C, GLU182D, GLU213C, GLU220C, GLU6C, GLY153D, GLY156D, GLY160D, GLY164D, GLY165D, GLY167D, GLY176C, GLY176D, GLY199C, HIS135C, HIS138C, ILE115C, ILE131D, ILE145C, ILE151D, ILE174C, ILE183D, LEU137C, LEU143C, LEU186D, LEU196C, LEU200C, LEU222C, LEU229C, LEU232C, LEU236C, LEU249C, LEU256C, LEU9C, LYS120C, LYS158D, LYS178D, LYS179D, LYS233C, MET139C, MET140C, MET171C, MET171D, MET198C, MET198D, MET221C, MET227C, PHE152C, PHE152D, PHE162D, PHE185D, PRO121C, PRO157D, PRO226C, PRO4C, SER161D, SER169C, SER169D, SER225C, THR144C, THR155D, THR203C, THR214C, TRP166D, TRP184D, TRP217C, TYR10C, TYR129D, TYR170C, TYR170D, TYR190D, TYR3C, VAL122C, VAL123C, VAL126C, VAL136C, VAL159D, VAL175C, VAL175D, VAL201C, VAL71C
• C-E: ALA168C, ALA168E, ALA172C, ALA172E, ALA238C, ALA238E, ALA244C, ALA244E, ALA250C, ALA250E, ALA253C, ALA253E, ALA269E, ALA47C, ARG113C, ARG113E, ARG116C, ARG116E, ARG173C, ARG173E, ARG230C, ARG230E, ARG267E, ARG274E, ARG64C, ARG64E, ASN107C, ASN107E, ASN237C, ASN237E, ASN252C, ASN252E, ASN268E, ASN271E, ASP110C, ASP110E, ASP163C, ASP163E, ASP239C, ASP239E, ASP241C, ASP241E, ASP87C, CYS118C, CYS118E, CYS240C, CYS240E, GLN112C, GLN112E, GLN114C, GLN114E, GLN177C, GLN177E, GLN243C, GLN243E, GLN247C, GLN247E, GLN264E, GLN275E, GLN88C, GLU248C, GLU248E, GLU261C, GLU261E, GLU262C, GLU262E, GLU265E, GLY156C, GLY156E, GLY160C, GLY160E, GLY164C, GLY164E, GLY165C, GLY165E, GLY167C, GLY167E, GLY242C, GLY242E, GLY245C, GLY245E, GLY251C, GLY251E, GLY263C, GLY263E, GLY266E, GLY85C, GLY86C, GLY86E, HIS104C, HIS104E, HIS105C, HIS105E, ILE115C, ILE115E, ILE131C, ILE174C, ILE174E, ILE57C, ILE57E, LEU106C, LEU106E, LEU109C, LEU109E, LEU246C, LEU246E, LEU249C, LEU249E, LEU256C, LEU256E, LYS158C, LYS158E, LYS54C, LYS54E, MET140C, MET140E, MET171C, MET171E, MET227C, MET255C, MET255E, MET259C, MET259E, PHE111C, PHE111E, PHE162C, PHE162E, PHE257C, PHE257E, PHE270E, PHE278E, PRO119C, PRO119E, PRO157C, PRO157E, PRO276E, SER161C, SER161E, SER169C, SER169E, SER84C, THR117C, THR117E, THR155C, THR254C, THR254E, THR260C, THR260E, TRP166C, TRP166E, TYR170C, TYR170E, TYR258C, TYR258E, TYR65C, TYR65E, VAL103E, VAL108C, VAL108E, VAL136C, VAL136E, VAL159C, VAL159E
• C-F: ARG173C, ARG173F, ARG181C, ARG181F, GLN177C, GLN177F, GLN243C, GLN243F
• D-E: ARG173D, ARG173E, ARG181D, ARG181E, GLN177D, GLN177E, GLN243D, GLN243E
• D-F: ALA228D, ALA228F, ALA234D, ALA234F, ALA235D, ALA235F, ALA238D, ALA238F, ALA250D, ALA250F, ALA253D, ALA253F, ALA61D, ALA61F, ALA63D, ALA63F, ARG173D, ARG173F, ARG219F, ARG230D, ARG230F, ARG274F, ARG283D, ARG283F, ARG64D, ARG64F, ASN224D, ASN224F, ASN237D, ASN237F, ASN252D, ASN252F, ASN284D, ASN284F, ASN68D, ASN68F, ASP239D, ASP239F, ASP241D, ASP241F, ASP277D, ASP277F, ASP32D, ASP32F, ASP5D, ASP62F, ASP66D, ASP66F, ASP67D, ASP67F, CYS118D, CYS118F, CYS218F, CYS231D, CYS231F, CYS240D, CYS240F, GLN223D, GLN223F, GLN243D, GLN243F, GLN247D, GLN247F, GLN264D, GLN264F, GLN275D, GLN275F, GLU248D, GLU248F, GLU261D, GLU261F, GLU262D, GLU262F, GLU265D, GLU265F, GLY242D, GLY242F, GLY245D, GLY245F, GLY251D, GLY251F, GLY263D, GLY263F, GLY266D, GLY266F, GLY33D, GLY33F, GLY70D, GLY70F, ILE2D, ILE69D, ILE69F, LEU222D, LEU222F, LEU229D, LEU229F, LEU232D, LEU232F, LEU236D, LEU236F, LEU246D, LEU246F, LEU249D, LEU249F, LEU256D, LEU256F, LYS120D, LYS120F, LYS280D, LYS280F, LYS282D, LYS282F, MET221D, MET221F, MET227D, MET227F, MET255D, MET255F, MET259D, MET259F, MET8D, PHE257D, PHE257F, PHE278D, PHE278F, PHE281D, PHE281F, PRO119D, PRO119F, PRO121D, PRO121F, PRO226D, PRO226F, PRO276D, PRO276F, PRO285D, PRO285F, PRO4D, PRO4F, SER225D, SER225F, SER279D, SER279F, THR117D, THR117F, THR254D, THR254F, THR260D, THR260F, TYR258D, TYR258F, TYR3D, TYR3F, TYR65D, TYR65F, VAL71D, VAL71F
• E-F: ALA124E, ALA168F, ALA172E, ALA172F, ALA180F, ALA228E, ALA234E, ALA235E, ALA238E, ALA253E, ARG113F, ARG116E, ARG173E, ARG173F, ARG181F, ARG188F, ARG216E, ARG219E, ARG230E, ASN107F, ASN202E, ASN224E, ASN237E, ASN252E, ASN284E, ASP110F, ASP142E, ASP163F, ASP197E, ASP197F, ASP239E, ASP239F, ASP241E, CYS118E, CYS141E, CYS187F, CYS218E, CYS231E, CYS240E, CYS240F, GLN154F, GLN177F, GLN189F, GLN223E, GLU182F, GLU213E, GLU220E, GLY156F, GLY160F, GLY164F, GLY165F, GLY167F, GLY176E, GLY176F, GLY199E, HIS104F, HIS105F, HIS135E, HIS138E, ILE115E, ILE145E, ILE174E, ILE183F, ILE2E, LEU106F, LEU109F, LEU137E, LEU143E, LEU186F, LEU196E, LEU200E, LEU222E, LEU229E, LEU232E, LEU236E, LEU249E, LEU256E, LEU9E, LYS120E, LYS158F, LYS178F, LYS179F, LYS233E, MET139E, MET139F, MET140E, MET171E, MET171F, MET198E, MET198F, MET221E, MET227E, MET8E, PHE152E, PHE162F, PHE185F, PRO121E, PRO157F, PRO226E, PRO285E, PRO4E, SER161F, SER169E, SER169F, SER225E, THR144E, THR155F, THR203E, THR214E, TRP166F, TRP184F, TRP217E, TYR10E, TYR170E, TYR170F, TYR190F, TYR3E, VAL103F, VAL122E, VAL123E, VAL126E, VAL136E, VAL159F, VAL175E, VAL175F, VAL201E, VAL71E