3T88

crystal structure of escherichia coli menb in complex with substrate analogue, osb-ncoa

• Total interactions analyzed: 15
• Total true interactions: 15
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 141
  • Norm. En. per Res.: -4.3409
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-116.8465	-52.3294	-442.894	-612.0699	141	16	9	16786	5	34	34
A-C	-96.9754	-53.5148	-419.618	-570.1082	137	12	8	16475	5	33	34
A-D	-57.6994	-10.7274	-362.978	-431.4048	153	8	17	14837	0	20	28
A-E	-82.7716	-56.8263	-766.782	-906.38	218	18	5	26280	12	46	56
A-F	0.0	0.0	-0.0894	-0.0894	8	0	0	40	0	0	0
B-C	-94.4465	-52.1646	-441.184	-587.7951	143	11	9	17003	5	35	34
B-D	0.0	0.0	-0.1245	-0.1245	8	0	0	45	0	0	0
B-E	-58.842	-10.8466	-362.129	-431.8176	149	8	17	14585	0	20	28
B-F	-88.2522	-70.1084	-768.533	-926.8935	220	20	5	26182	12	46	57
C-D	-85.1076	-53.6484	-730.789	-869.5451	219	19	5	25462	13	45	57
C-E	0.0	0.0	-0.1398	-0.1398	8	0	0	45	0	0	0
C-F	-61.6974	-29.4945	-366.457	-457.6489	149	5	16	14670	1	20	28
D-E	-104.6945	-52.5826	-445.395	-602.6721	140	13	9	16739	5	34	34
D-F	-95.6248	-47.9352	-434.816	-578.3759	138	12	8	16675	5	34	33
E-F	-95.6768	-47.9149	-427.199	-570.7908	137	17	8	16323	5	35	33

Interface residues

• A-B: ALA124B, ALA168A, ALA172A, ALA172B, ALA180A, ALA228B, ALA234B, ALA235B, ALA238B, ALA253B, ARG116B, ARG173A, ARG173B, ARG181A, ARG188A, ARG216B, ARG219B, ARG230B, ARG283B, ASN107A, ASN202B, ASN224B, ASN237B, ASN252B, ASN284B, ASP110A, ASP142B, ASP163A, ASP197A, ASP197B, ASP239A, ASP239B, ASP241B, ASP93A, ASP99A, CYS118B, CYS141B, CYS187A, CYS218B, CYS231B, CYS240A, CYS240B, GLN154A, GLN177A, GLN189A, GLN223B, GLU182A, GLU213B, GLU220B, GLU261B, GLU262B, GLY102A, GLY156A, GLY160A, GLY164A, GLY165A, GLY167A, GLY176A, GLY176B, GLY199B, GLY95A, GLY96A, HIS104A, HIS105A, HIS135B, HIS138B, ILE115B, ILE145B, ILE174B, ILE183A, LEU106A, LEU109A, LEU137B, LEU143B, LEU186A, LEU196B, LEU200B, LEU222B, LEU229B, LEU232B, LEU236B, LEU249B, LEU256B, LEU9B, LYS120B, LYS158A, LYS178A, LYS179A, LYS233B, LYS280B, LYS282B, MET139A, MET139B, MET140B, MET171A, MET171B, MET198A, MET198B, MET221B, MET227B, MET8B, PHE152B, PHE162A, PHE185A, PHE278B, PHE281B, PRO119B, PRO121B, PRO157A, PRO226B, PRO285B, PRO50A, SER161A, SER169A, SER169B, SER225B, THR144B, THR155A, THR203B, THR214B, THR260B, TRP166A, TRP184A, TRP217B, TYR10B, TYR170A, TYR170B, TYR190A, TYR94A, TYR97A, VAL103A, VAL122B, VAL123B, VAL126B, VAL136A, VAL136B, VAL159A, VAL175A, VAL175B, VAL201B, VAL71B
• A-C: ALA124A, ALA168C, ALA172A, ALA172C, ALA180C, ALA228A, ALA234A, ALA235A, ALA238A, ALA253A, ARG113C, ARG116A, ARG173A, ARG173C, ARG181C, ARG188C, ARG216A, ARG219A, ARG230A, ARG283A, ASN107C, ASN202A, ASN224A, ASN237A, ASN252A, ASN284A, ASP110C, ASP142A, ASP163C, ASP197A, ASP197C, ASP239A, ASP239C, ASP241A, ASP99C, CYS118A, CYS141A, CYS187C, CYS218A, CYS231A, CYS240A, CYS240C, GLN154C, GLN177C, GLN189C, GLN223A, GLU182C, GLU213A, GLU220A, GLU261A, GLU262A, GLY102C, GLY156C, GLY160C, GLY164C, GLY165C, GLY167C, GLY176A, GLY176C, GLY199A, GLY95C, GLY96C, HIS104C, HIS105C, HIS135A, HIS138A, ILE115A, ILE145A, ILE174A, ILE183C, LEU106C, LEU109C, LEU137A, LEU143A, LEU186C, LEU196A, LEU200A, LEU222A, LEU229A, LEU232A, LEU236A, LEU249A, LEU256A, LEU9A, LYS120A, LYS158C, LYS178C, LYS179C, LYS233A, LYS280A, LYS282A, MET139A, MET140A, MET171A, MET171C, MET198A, MET198C, MET221A, MET227A, PHE152A, PHE162C, PHE185C, PHE281A, PRO119A, PRO121A, PRO157C, PRO226A, PRO285A, PRO50C, SER161C, SER169A, SER169C, SER225A, THR144A, THR155C, THR203A, THR214A, THR260A, TRP166C, TRP184C, TRP217A, TYR10A, TYR170A, TYR170C, TYR190C, TYR94C, TYR97C, VAL103C, VAL122A, VAL123A, VAL126A, VAL136A, VAL159C, VAL175A, VAL175C, VAL201A, VAL71A
• A-D: ALA228A, ALA228D, ALA234A, ALA234D, ALA235A, ALA235D, ALA238A, ALA238D, ALA250A, ALA250D, ALA253A, ALA253D, ALA61A, ALA61D, ALA63A, ALA63D, ARG173A, ARG173D, ARG230A, ARG230D, ARG283A, ARG283D, ARG64A, ARG64D, ASN224A, ASN224D, ASN237A, ASN237D, ASN252A, ASN252D, ASN284A, ASN284D, ASN68A, ASN68D, ASP239A, ASP239D, ASP241A, ASP241D, ASP277A, ASP277D, ASP32A, ASP32D, ASP5D, ASP66A, ASP66D, ASP67A, ASP67D, CYS118A, CYS118D, CYS218A, CYS218D, CYS231A, CYS231D, CYS240A, CYS240D, GLN223A, GLN223D, GLN243A, GLN243D, GLN247A, GLN247D, GLN264A, GLN264D, GLN275A, GLN275D, GLU248A, GLU248D, GLU261A, GLU261D, GLU262A, GLU262D, GLU265A, GLU265D, GLY242A, GLY242D, GLY245A, GLY245D, GLY251A, GLY251D, GLY263A, GLY263D, GLY266A, GLY266D, GLY33A, GLY33D, GLY70A, GLY70D, ILE34A, ILE34D, ILE69A, ILE69D, LEU222A, LEU222D, LEU229A, LEU229D, LEU232A, LEU232D, LEU236A, LEU236D, LEU246A, LEU246D, LEU249A, LEU249D, LEU256A, LEU256D, LYS120A, LYS120D, LYS280A, LYS280D, LYS282A, LYS282D, MET221A, MET221D, MET227A, MET227D, MET255A, MET255D, MET259A, MET259D, MET8A, MET8D, PHE257A, PHE257D, PHE278A, PHE278D, PHE281A, PHE281D, PRO119A, PRO119D, PRO121A, PRO121D, PRO226A, PRO226D, PRO276A, PRO276D, PRO285A, PRO285D, SER225A, SER225D, SER279A, SER279D, THR117A, THR117D, THR254A, THR254D, THR260A, THR260D, TYR258A, TYR258D, TYR65A, TYR65D, VAL71A, VAL71D
• A-E: ALA168A, ALA168E, ALA172A, ALA172E, ALA238A, ALA238E, ALA244A, ALA244E, ALA250A, ALA250E, ALA253A, ALA253E, ALA269A, ALA269E, ALA47A, ALA47E, ARG113A, ARG113E, ARG116A, ARG116E, ARG173A, ARG173E, ARG230A, ARG230E, ARG267A, ARG267E, ARG274A, ARG274E, ARG45A, ARG45E, ARG64A, ARG64E, ARG91A, ARG91E, ASN107A, ASN107E, ASN237A, ASN237E, ASN252A, ASN252E, ASN268A, ASN268E, ASN271A, ASN271E, ASP110A, ASP110E, ASP163A, ASP163E, ASP239A, ASP239E, ASP241A, ASP241E, ASP67A, ASP67E, ASP87A, ASP87E, ASP93A, ASP93E, ASP99A, ASP99E, CYS118E, CYS240A, CYS240E, GLN112A, GLN112E, GLN114A, GLN114E, GLN177A, GLN177E, GLN243A, GLN243E, GLN247A, GLN247E, GLN264A, GLN264E, GLN275A, GLN275E, GLN88A, GLN88E, GLU248A, GLU248E, GLU261A, GLU261E, GLU262A, GLU262E, GLU265A, GLU265E, GLY133A, GLY133E, GLY156A, GLY156E, GLY160A, GLY160E, GLY164A, GLY164E, GLY165A, GLY165E, GLY167A, GLY167E, GLY242A, GLY242E, GLY245A, GLY245E, GLY251A, GLY251E, GLY263A, GLY263E, GLY266A, GLY266E, GLY86A, GLY86E, GLY92A, GLY92E, GLY95A, GLY95E, GLY96A, GLY96E, HIS104A, HIS104E, HIS105A, HIS105E, ILE115A, ILE115E, ILE131A, ILE131E, ILE174A, ILE174E, ILE57A, ILE57E, LEU106A, LEU106E, LEU109A, LEU109E, LEU246A, LEU246E, LEU249A, LEU249E, LEU256A, LEU256E, LYS158A, LYS158E, LYS273A, LYS273E, LYS54A, LYS54E, LYS89A, LYS89E, LYS98A, LYS98E, MET140A, MET140E, MET171A, MET171E, MET227A, MET227E, MET255A, MET255E, MET259A, MET259E, PHE111A, PHE111E, PHE162A, PHE162E, PHE257A, PHE257E, PHE270A, PHE270E, PHE278A, PHE278E, PHE48A, PRO119E, PRO157A, PRO157E, PRO226A, PRO226E, PRO276A, PRO276E, PRO50A, PRO50E, SER161A, SER161E, SER169A, SER169E, SER84A, SER84E, THR117A, THR117E, THR155A, THR155E, THR254A, THR254E, THR260A, THR260E, TRP166A, TRP166E, TYR170A, TYR170E, TYR258A, TYR258E, TYR65A, TYR65E, TYR94A, TYR94E, TYR97A, TYR97E, VAL103A, VAL103E, VAL108A, VAL108E, VAL136A, VAL136E, VAL159A, VAL159E, VAL44A, VAL44E, VAL53E, VAL90A, VAL90E
• A-F: ARG173A, ARG173F, ARG181A, ARG181F, GLN177A, GLN177F, GLN243A, GLN243F
• B-C: ALA124C, ALA168B, ALA172B, ALA172C, ALA180B, ALA228C, ALA234C, ALA235C, ALA238C, ALA253C, ARG113B, ARG116C, ARG173B, ARG173C, ARG181B, ARG188B, ARG216C, ARG219C, ARG230C, ARG283C, ASN107B, ASN202C, ASN224C, ASN237C, ASN252C, ASN284C, ASP110B, ASP142C, ASP163B, ASP197B, ASP197C, ASP239B, ASP239C, ASP241C, ASP5C, ASP93B, ASP99B, CYS118C, CYS141C, CYS187B, CYS218C, CYS231C, CYS240B, CYS240C, GLN154B, GLN177B, GLN189B, GLN223C, GLU182B, GLU213C, GLU220C, GLU261C, GLU262C, GLY102B, GLY156B, GLY160B, GLY164B, GLY165B, GLY167B, GLY176B, GLY176C, GLY199C, GLY95B, GLY96B, HIS104B, HIS105B, HIS135C, HIS138C, ILE115C, ILE145C, ILE174C, ILE183B, LEU106B, LEU109B, LEU137C, LEU143C, LEU186B, LEU196C, LEU200C, LEU222C, LEU229C, LEU232C, LEU236C, LEU249C, LEU256C, LEU9C, LYS120C, LYS158B, LYS178B, LYS179B, LYS193C, LYS233C, LYS280C, LYS282C, MET139B, MET139C, MET140C, MET171B, MET171C, MET198B, MET198C, MET221C, MET227C, PHE152C, PHE162B, PHE185B, PHE278C, PHE281C, PRO119C, PRO121C, PRO157B, PRO226C, PRO285C, PRO50B, SER101B, SER161B, SER169B, SER169C, SER225C, THR144C, THR155B, THR203C, THR214C, THR260C, TRP166B, TRP184B, TRP217C, TYR10C, TYR170B, TYR170C, TYR190B, TYR94B, TYR97B, VAL103B, VAL122C, VAL123C, VAL126C, VAL136C, VAL159B, VAL175B, VAL175C, VAL201C, VAL71C
• B-D: ARG173B, ARG173D, ARG181B, ARG181D, GLN177B, GLN177D, GLN243B, GLN243D
• B-E: ALA228B, ALA228E, ALA234B, ALA234E, ALA235B, ALA235E, ALA238B, ALA238E, ALA250B, ALA250E, ALA253B, ALA253E, ALA61B, ALA61E, ALA63B, ALA63E, ARG173B, ARG173E, ARG230B, ARG230E, ARG283B, ARG283E, ARG64B, ARG64E, ASN224B, ASN224E, ASN237B, ASN237E, ASN252B, ASN252E, ASN284B, ASN284E, ASN68B, ASN68E, ASP239B, ASP239E, ASP241B, ASP241E, ASP277B, ASP277E, ASP32B, ASP32E, ASP5B, ASP66B, ASP66E, ASP67B, ASP67E, CYS118B, CYS118E, CYS218B, CYS218E, CYS231B, CYS231E, CYS240B, CYS240E, GLN223B, GLN223E, GLN243B, GLN243E, GLN247B, GLN247E, GLN264B, GLN264E, GLN275B, GLN275E, GLU248B, GLU248E, GLU261B, GLU261E, GLU262B, GLU262E, GLU265B, GLU265E, GLY242B, GLY242E, GLY245B, GLY245E, GLY251B, GLY251E, GLY263B, GLY263E, GLY266B, GLY266E, GLY33B, GLY33E, GLY70B, GLY70E, ILE34B, ILE69B, ILE69E, LEU222B, LEU222E, LEU229B, LEU229E, LEU232B, LEU232E, LEU236B, LEU236E, LEU246B, LEU246E, LEU249B, LEU249E, LEU256B, LEU256E, LYS120B, LYS120E, LYS282B, LYS282E, MET221B, MET221E, MET227B, MET227E, MET255B, MET255E, MET259B, MET259E, MET8B, PHE257B, PHE257E, PHE278B, PHE278E, PHE281B, PHE281E, PRO119B, PRO119E, PRO121B, PRO121E, PRO226B, PRO226E, PRO276B, PRO276E, PRO285B, PRO285E, SER225B, SER225E, SER279B, SER279E, THR117B, THR117E, THR254B, THR254E, THR260B, THR260E, TYR258B, TYR258E, TYR65B, TYR65E, VAL71B, VAL71E
• B-F: ALA168B, ALA168F, ALA172B, ALA172F, ALA234B, ALA238B, ALA238F, ALA244B, ALA244F, ALA250B, ALA250F, ALA253B, ALA253F, ALA269B, ALA269F, ALA47B, ALA47F, ARG113B, ARG113F, ARG116B, ARG116F, ARG173B, ARG173F, ARG230B, ARG230F, ARG267B, ARG267F, ARG274B, ARG45B, ARG45F, ARG64B, ARG64F, ARG91B, ARG91F, ASN107B, ASN107F, ASN237B, ASN237F, ASN252B, ASN252F, ASN268B, ASN268F, ASN271B, ASN271F, ASP110B, ASP110F, ASP163B, ASP163F, ASP239B, ASP239F, ASP241B, ASP241F, ASP277F, ASP67B, ASP67F, ASP87B, ASP87F, ASP93B, ASP93F, ASP99B, ASP99F, CYS118B, CYS118F, CYS240B, CYS240F, GLN112B, GLN112F, GLN114B, GLN114F, GLN177B, GLN177F, GLN243B, GLN243F, GLN247B, GLN247F, GLN264B, GLN264F, GLN275B, GLN275F, GLN88B, GLN88F, GLU248B, GLU248F, GLU261B, GLU261F, GLU262B, GLU262F, GLU265B, GLU265F, GLY156B, GLY156F, GLY160B, GLY160F, GLY164B, GLY164F, GLY165B, GLY165F, GLY167B, GLY167F, GLY242B, GLY242F, GLY245B, GLY245F, GLY251B, GLY251F, GLY263B, GLY263F, GLY266B, GLY266F, GLY86B, GLY86F, GLY92B, GLY92F, GLY95B, GLY95F, GLY96B, GLY96F, HIS104B, HIS104F, HIS105B, HIS105F, ILE115B, ILE115F, ILE131B, ILE131F, ILE174B, ILE174F, ILE57B, ILE57F, LEU106B, LEU106F, LEU109B, LEU109F, LEU246B, LEU246F, LEU249B, LEU249F, LEU256B, LEU256F, LYS158B, LYS158F, LYS273B, LYS273F, LYS54B, LYS54F, LYS89B, LYS89F, LYS98B, LYS98F, MET140B, MET140F, MET171B, MET171F, MET227B, MET227F, MET255B, MET255F, MET259B, MET259F, PHE111B, PHE111F, PHE162B, PHE162F, PHE257B, PHE257F, PHE270B, PHE270F, PHE278B, PHE278F, PHE48B, PRO119B, PRO119F, PRO157B, PRO157F, PRO226B, PRO226F, PRO276B, PRO276F, PRO50B, PRO50F, SER161B, SER161F, SER169B, SER169F, SER84B, SER84F, THR117B, THR117F, THR155B, THR155F, THR254B, THR254F, THR260B, THR260F, TRP166B, TRP166F, TRP184B, TYR170B, TYR170F, TYR258B, TYR258F, TYR65B, TYR65F, TYR94B, TYR94F, TYR97B, TYR97F, VAL103B, VAL103F, VAL108B, VAL108F, VAL136B, VAL136F, VAL159B, VAL159F, VAL44B, VAL44F, VAL53B, VAL90B, VAL90F
• C-D: ALA168C, ALA168D, ALA172C, ALA172D, ALA238C, ALA238D, ALA244C, ALA244D, ALA250C, ALA250D, ALA253C, ALA253D, ALA269C, ALA269D, ALA47C, ALA47D, ARG113C, ARG113D, ARG116C, ARG116D, ARG173C, ARG173D, ARG230C, ARG230D, ARG267C, ARG267D, ARG274C, ARG274D, ARG45C, ARG45D, ARG64C, ARG64D, ARG91C, ARG91D, ASN107C, ASN107D, ASN237C, ASN237D, ASN252C, ASN252D, ASN268C, ASN268D, ASN271C, ASN271D, ASP110C, ASP110D, ASP163C, ASP163D, ASP239C, ASP239D, ASP241C, ASP241D, ASP277C, ASP67C, ASP67D, ASP87C, ASP87D, ASP93C, ASP93D, ASP99C, ASP99D, CYS118D, CYS187C, CYS187D, CYS240C, CYS240D, GLN112C, GLN112D, GLN114C, GLN114D, GLN177C, GLN177D, GLN243C, GLN243D, GLN247C, GLN247D, GLN264C, GLN264D, GLN275C, GLN275D, GLN88C, GLN88D, GLU248C, GLU248D, GLU261C, GLU261D, GLU262C, GLU262D, GLU265C, GLU265D, GLY133C, GLY156C, GLY156D, GLY160C, GLY160D, GLY164C, GLY164D, GLY165C, GLY165D, GLY167C, GLY167D, GLY242C, GLY242D, GLY245C, GLY245D, GLY251C, GLY251D, GLY263C, GLY263D, GLY266C, GLY266D, GLY86C, GLY86D, GLY92C, GLY92D, GLY95C, GLY95D, GLY96C, GLY96D, HIS104C, HIS104D, HIS105C, HIS105D, ILE115C, ILE115D, ILE131C, ILE131D, ILE174C, ILE174D, ILE57C, ILE57D, LEU106C, LEU106D, LEU109C, LEU109D, LEU246C, LEU246D, LEU249C, LEU249D, LEU256C, LEU256D, LYS158C, LYS158D, LYS273C, LYS273D, LYS54C, LYS54D, LYS89C, LYS89D, LYS98C, LYS98D, MET140C, MET140D, MET171C, MET171D, MET227C, MET227D, MET255C, MET255D, MET259C, MET259D, PHE111C, PHE111D, PHE162C, PHE162D, PHE257C, PHE257D, PHE270C, PHE270D, PHE278C, PHE278D, PHE48C, PRO119C, PRO119D, PRO157C, PRO157D, PRO226C, PRO276C, PRO276D, PRO50C, PRO50D, SER161C, SER161D, SER169C, SER169D, SER84C, SER84D, THR117C, THR117D, THR155C, THR155D, THR254C, THR254D, THR260C, THR260D, TRP166C, TRP166D, TYR170C, TYR170D, TYR258C, TYR258D, TYR65C, TYR65D, TYR94C, TYR94D, TYR97C, TYR97D, VAL103C, VAL103D, VAL108C, VAL108D, VAL136C, VAL136D, VAL159C, VAL159D, VAL44C, VAL44D, VAL90C, VAL90D
• C-E: ARG173C, ARG173E, ARG181C, ARG181E, GLN177C, GLN177E, GLN243C, GLN243E
• C-F: ALA228C, ALA228F, ALA234C, ALA234F, ALA235C, ALA235F, ALA238C, ALA238F, ALA250C, ALA250F, ALA253C, ALA253F, ALA61C, ALA61F, ALA63C, ALA63F, ARG173C, ARG173F, ARG230C, ARG230F, ARG283C, ARG283F, ARG64C, ARG64F, ASN224C, ASN224F, ASN237C, ASN237F, ASN252C, ASN252F, ASN284C, ASN284F, ASN68C, ASN68F, ASP239C, ASP239F, ASP241C, ASP241F, ASP277C, ASP277F, ASP32C, ASP32F, ASP5C, ASP66C, ASP66F, ASP67C, ASP67F, CYS118C, CYS118F, CYS218C, CYS218F, CYS231C, CYS231F, CYS240C, CYS240F, GLN223C, GLN223F, GLN243C, GLN243F, GLN247C, GLN247F, GLN264C, GLN264F, GLN275C, GLN275F, GLU248C, GLU248F, GLU261C, GLU261F, GLU262C, GLU262F, GLU265C, GLU265F, GLY242C, GLY242F, GLY245C, GLY245F, GLY251C, GLY251F, GLY263C, GLY263F, GLY266C, GLY266F, GLY33C, GLY33F, GLY70C, GLY70F, ILE34C, ILE34F, ILE69C, ILE69F, LEU222C, LEU222F, LEU229C, LEU229F, LEU232C, LEU232F, LEU236C, LEU236F, LEU246C, LEU246F, LEU249C, LEU249F, LEU256C, LEU256F, LYS120C, LYS120F, LYS282C, LYS282F, MET221C, MET221F, MET227C, MET227F, MET255C, MET255F, MET259C, MET259F, PHE257C, PHE257F, PHE278C, PHE278F, PHE281C, PHE281F, PRO119C, PRO119F, PRO121C, PRO121F, PRO226C, PRO226F, PRO276C, PRO276F, PRO285C, PRO285F, SER225C, SER225F, SER279C, SER279F, THR117C, THR117F, THR254C, THR254F, THR260C, THR260F, TYR258C, TYR258F, TYR65C, TYR65F, VAL71C, VAL71F
• D-E: ALA124D, ALA168E, ALA172D, ALA172E, ALA180E, ALA228D, ALA234D, ALA235D, ALA238D, ALA253D, ARG116D, ARG173D, ARG173E, ARG181E, ARG188E, ARG216D, ARG219D, ARG230D, ARG283D, ASN107E, ASN202D, ASN224D, ASN237D, ASN252D, ASN284D, ASP110E, ASP142D, ASP163E, ASP197D, ASP197E, ASP239D, ASP239E, ASP241D, ASP93E, ASP99E, CYS118D, CYS141D, CYS187E, CYS218D, CYS231D, CYS240D, CYS240E, GLN154E, GLN177E, GLN189E, GLN223D, GLU182E, GLU213D, GLU220D, GLU261D, GLU262D, GLY102E, GLY156E, GLY160E, GLY164E, GLY165E, GLY167E, GLY176D, GLY176E, GLY199D, GLY95E, GLY96E, HIS104E, HIS105E, HIS135D, HIS138D, ILE115D, ILE145D, ILE174D, ILE183E, LEU106E, LEU109E, LEU137D, LEU143D, LEU186E, LEU196D, LEU200D, LEU222D, LEU229D, LEU232D, LEU236D, LEU249D, LEU256D, LEU9D, LYS120D, LYS158E, LYS178E, LYS179E, LYS233D, LYS280D, LYS282D, MET139D, MET139E, MET140D, MET171D, MET171E, MET198D, MET198E, MET221D, MET227D, PHE152D, PHE162E, PHE185E, PHE257D, PHE281D, PRO119D, PRO121D, PRO157E, PRO226D, PRO285D, PRO50E, SER161E, SER169D, SER169E, SER225D, THR144D, THR155E, THR203D, THR214D, THR260D, TRP166E, TRP184E, TRP217D, TYR10D, TYR170D, TYR170E, TYR190E, TYR94E, TYR97E, VAL103E, VAL122D, VAL123D, VAL126D, VAL136D, VAL159E, VAL175D, VAL175E, VAL201D, VAL204D, VAL71D
• D-F: ALA124F, ALA168D, ALA172D, ALA172F, ALA180D, ALA228F, ALA234F, ALA235F, ALA238F, ALA253F, ARG116F, ARG173D, ARG173F, ARG181D, ARG188D, ARG216F, ARG219F, ARG230F, ARG283F, ASN107D, ASN202F, ASN224F, ASN237F, ASN252F, ASN284F, ASP110D, ASP142F, ASP163D, ASP197D, ASP197F, ASP239D, ASP239F, ASP241F, ASP93D, ASP99D, CYS118F, CYS141F, CYS187D, CYS218F, CYS231F, CYS240D, CYS240F, GLN154D, GLN177D, GLN189D, GLN223F, GLU182D, GLU213F, GLU220F, GLU261F, GLU262F, GLY102D, GLY156D, GLY160D, GLY164D, GLY165D, GLY167D, GLY176D, GLY176F, GLY199F, GLY95D, GLY96D, HIS104D, HIS105D, HIS135F, HIS138F, ILE115F, ILE145F, ILE174F, ILE183D, LEU106D, LEU109D, LEU137F, LEU143F, LEU186D, LEU196F, LEU200F, LEU222F, LEU229F, LEU232F, LEU236F, LEU249F, LEU256F, LEU9F, LYS120F, LYS158D, LYS178D, LYS179D, LYS233F, LYS280F, LYS282F, MET139F, MET140F, MET171D, MET171F, MET198D, MET198F, MET221F, MET227F, PHE152F, PHE162D, PHE185D, PHE278F, PHE281F, PRO121F, PRO157D, PRO226F, PRO285F, PRO50D, SER101D, SER161D, SER169D, SER169F, SER225F, THR144F, THR155D, THR203F, THR214F, THR260F, TRP166D, TRP184D, TRP217F, TYR10F, TYR170D, TYR170F, TYR190D, TYR94D, TYR97D, VAL103D, VAL122F, VAL123F, VAL126F, VAL136F, VAL159D, VAL175D, VAL175F, VAL201F, VAL71F
• E-F: ALA124E, ALA168F, ALA172E, ALA172F, ALA180F, ALA228E, ALA234E, ALA235E, ALA238E, ALA253E, ARG113F, ARG116E, ARG173E, ARG173F, ARG181F, ARG188F, ARG216E, ARG219E, ARG230E, ARG283E, ASN107F, ASN202E, ASN224E, ASN237E, ASN252E, ASN284E, ASP110F, ASP142E, ASP163F, ASP197E, ASP197F, ASP239E, ASP239F, ASP241E, ASP93F, ASP99F, CYS118E, CYS141E, CYS187F, CYS218E, CYS231E, CYS240E, CYS240F, GLN154F, GLN177F, GLN223E, GLU182F, GLU213E, GLU220E, GLU261E, GLU262E, GLY102F, GLY156F, GLY160F, GLY164F, GLY165F, GLY167F, GLY176E, GLY176F, GLY199E, GLY95F, GLY96F, HIS104F, HIS105F, HIS135E, HIS138E, ILE115E, ILE145E, ILE174E, ILE183F, LEU106F, LEU109F, LEU137E, LEU143E, LEU186F, LEU196E, LEU200E, LEU222E, LEU229E, LEU232E, LEU236E, LEU249E, LEU256E, LEU9E, LYS120E, LYS158F, LYS178F, LYS179F, LYS233E, LYS280E, LYS282E, MET139E, MET140E, MET171E, MET171F, MET198E, MET198F, MET221E, MET227E, PHE152E, PHE162F, PHE185F, PHE278E, PHE281E, PRO121E, PRO157F, PRO226E, PRO285E, PRO50F, SER161F, SER169E, SER169F, SER225E, THR144E, THR155F, THR203E, THR214E, THR260E, TRP166F, TRP184F, TRP217E, TYR10E, TYR170E, TYR170F, TYR190F, TYR94F, TYR97F, VAL103F, VAL122E, VAL123E, VAL126E, VAL136E, VAL159F, VAL175E, VAL175F, VAL201E, VAL71E