3T30

human nucleoplasmin (npm2): a histone chaperone in oocytes and early embryos

• Total interactions analyzed: 45
• Total true interactions: 22
• Strongest Interaction:
  • Chains: H-G
  • Int. Res.: 88
  • Norm. En. per Res.: -3.5333
• Hub Node: E(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
B-E	0.0	0.0	-0.0398	-0.0398	6	0	0	28	0	0	0
B-D	0.0	0.0	-0.0276	-0.0276	5	0	0	14	0	0	0
B-A	-15.847	-37.2189	-128.773	-181.8389	84	29	6	9490	2	10	11
B-C	-30.7073	-46.3769	-230.273	-307.3572	88	9	6	9522	3	11	12
E-D	-25.6854	-41.1182	-219.55	-286.3536	84	4	5	9072	2	9	12
E-A	-17.4042	-45.6857	-242.375	-305.4649	87	7	6	9666	2	10	11
E-C	0.0	0.0	-0.0275	-0.0275	5	0	0	15	0	0	0
E-J	0.0	0.0	-0.3081	-0.3081	4	0	0	107	0	0	1
E-F	0.0	0.0	-0.1588	-0.1588	7	0	0	53	0	0	0
D-A	0.0	0.0	-0.0191	-0.0191	4	0	0	10	0	0	0
D-C	-10.6893	-27.9579	-234.831	-273.4782	92	10	6	9893	2	10	11
A-C	0.0	0.0	-0.0074	-0.0074	5	0	0	7	0	0	0
H-I	-14.2674	-43.0612	-224.667	-281.9955	87	4	6	9492	2	9	13
H-J	0.0	0.0	-0.0281	-0.0281	5	0	0	17	0	0	0
H-F	0.0	0.0	-0.0524	-0.0524	5	0	0	20	0	0	0
H-G	-29.0954	-43.9893	-237.848	-310.9327	88	10	6	9919	2	10	12
I-J	-12.7585	-41.5424	-235.127	-289.428	91	12	8	10007	2	10	12
I-F	0.0	0.0	-0.0459	-0.0459	4	0	0	18	0	0	0
I-G	0.0	0.0	-0.0275	-0.0275	4	0	0	17	0	0	0
J-F	-12.3414	-31.8466	-235.072	-279.26	89	15	6	9723	2	11	13
J-G	0.0	0.0	-0.0262	-0.0262	4	0	0	13	0	0	0
F-G	-21.7831	-30.6	-232.072	-284.4552	89	9	6	9822	2	10	13

Interface residues

• B-E: LEU88B, LEU88E, PRO89B, SER86B, VAL87B, VAL87E
• B-D: LEU88B, LEU88D, SER86D, VAL87B, VAL87D
• B-A: ALA108A, ALA55B, ALA81A, ALA85B, ARG107A, ARG43A, ARG61A, CYS21B, CYS50B, GLN118B, GLN76A, GLN84A, GLN84B, GLN97A, GLU22B, GLU53B, GLU58A, GLU63A, GLY109A, GLY117B, GLY20B, GLY52B, GLY95A, GLY95B, HIS47A, HIS47B, HIS60A, ILE49A, ILE49B, ILE64A, ILE80A, LEU115B, LEU18B, LEU45B, LEU46A, LEU46B, LEU51A, LEU51B, LEU65A, LEU83A, LEU83B, LEU88A, LEU88B, LEU98A, LYS54B, MET59A, MET75A, MET90A, MET90B, MET93A, MET93B, PHE104A, PHE114B, PRO112B, PRO66A, PRO67A, PRO77A, PRO89A, PRO89B, SER116B, SER82A, SER86A, SER86B, SER92A, SER92B, SER99A, THR103A, THR15B, THR16B, THR48B, THR79A, TRP19B, VAL102A, VAL113B, VAL17B, VAL62A, VAL78A, VAL87A, VAL87B, VAL91A, VAL91B, VAL94A, VAL94B, VAL96A
• B-C: ALA108B, ALA55C, ALA81B, ALA85B, ALA85C, ARG107B, ARG120C, ARG43B, ARG61B, CYS21C, CYS50C, GLN118C, GLN76B, GLN84B, GLN84C, GLN97B, GLU119C, GLU22C, GLU53C, GLU57C, GLU58B, GLU63B, GLY109B, GLY117C, GLY20C, GLY52C, GLY95B, GLY95C, HIS47B, HIS47C, HIS60B, ILE49B, ILE49C, ILE64B, ILE80B, LEU115C, LEU18C, LEU44B, LEU45C, LEU46B, LEU46C, LEU51B, LEU51C, LEU65B, LEU83B, LEU83C, LEU88B, LEU88C, LEU98B, LYS54C, MET59B, MET90B, MET90C, MET93B, MET93C, PHE104B, PHE114C, PRO101B, PRO112C, PRO66B, PRO77B, PRO89B, PRO89C, SER116C, SER82B, SER86B, SER86C, SER92B, SER92C, SER99B, THR103B, THR15C, THR16C, THR48C, THR79B, TRP19C, VAL102B, VAL113C, VAL17C, VAL62B, VAL78B, VAL87B, VAL87C, VAL91B, VAL91C, VAL94B, VAL94C, VAL96B
• E-D: ALA108D, ALA55E, ALA81D, ALA85D, ALA85E, ARG107D, ARG43D, ARG61D, CYS21E, CYS50E, GLN118E, GLN84D, GLN84E, GLN97D, GLU22E, GLU53E, GLU57E, GLU58D, GLU63D, GLY109D, GLY117E, GLY20E, GLY52E, GLY95D, GLY95E, HIS47D, HIS47E, HIS60D, ILE49D, ILE49E, ILE64D, ILE80D, LEU115E, LEU18E, LEU44D, LEU45E, LEU46D, LEU46E, LEU51D, LEU51E, LEU65D, LEU83D, LEU83E, LEU88D, LEU88E, LEU98D, LYS54E, LYS56E, MET59D, MET90D, MET90E, MET93D, MET93E, PHE104D, PHE114E, PRO101D, PRO112E, PRO66D, PRO77D, PRO89D, PRO89E, SER116E, SER82D, SER86D, SER86E, SER92D, SER92E, SER99D, THR103D, THR48E, THR79D, TRP19E, VAL102D, VAL113E, VAL17E, VAL62D, VAL78D, VAL87D, VAL87E, VAL91D, VAL91E, VAL94D, VAL94E, VAL96D
• E-A: ALA108E, ALA55A, ALA81E, ALA85A, ALA85E, ARG107E, ARG120A, ARG27A, ARG43E, ARG61E, CYS21A, CYS50A, GLN118A, GLN76E, GLN84A, GLN84E, GLN97E, GLU22A, GLU53A, GLU58E, GLU63E, GLY109E, GLY117A, GLY20A, GLY52A, GLY95A, GLY95E, HIS47A, HIS47E, HIS60E, ILE49A, ILE49E, ILE64E, ILE80E, LEU115A, LEU18A, LEU44E, LEU45A, LEU46A, LEU46E, LEU51A, LEU51E, LEU65E, LEU83A, LEU83E, LEU88A, LEU88E, LEU98E, LYS54A, MET59E, MET90A, MET90E, MET93A, MET93E, PHE104E, PHE114A, PRO101E, PRO112A, PRO66E, PRO67E, PRO77E, PRO89A, PRO89E, SER116A, SER82E, SER86A, SER86E, SER92A, SER92E, SER99E, THR103E, THR16A, THR48A, THR79E, TRP19A, VAL102E, VAL113A, VAL17A, VAL62E, VAL78E, VAL87A, VAL87E, VAL91A, VAL91E, VAL94A, VAL94E, VAL96E
• E-C: LEU88C, LEU88E, SER86E, VAL87C, VAL87E
• E-J: ARG33E, CYS42E, PRO34E, THR15J
• E-F: ARG33F, CYS42F, GLN40E, PRO100F, PRO101F, PRO34F, SER99F
• D-A: LEU88A, LEU88D, VAL87A, VAL87D
• D-C: ALA108C, ALA55D, ALA81C, ALA85C, ALA85D, ARG107C, ARG120D, ARG43C, ARG61C, CYS21D, CYS50D, GLN118D, GLN76C, GLN84C, GLN84D, GLN97C, GLU119D, GLU22D, GLU53D, GLU57D, GLU58C, GLU63C, GLY109C, GLY117D, GLY20D, GLY52D, GLY95C, GLY95D, HIS47C, HIS47D, HIS60C, ILE49C, ILE49D, ILE64C, ILE80C, LEU115D, LEU18D, LEU44C, LEU45D, LEU46C, LEU46D, LEU51C, LEU51D, LEU65C, LEU83C, LEU83D, LEU88C, LEU88D, LEU98C, LYS54D, LYS56D, MET59C, MET75C, MET90C, MET90D, MET93C, MET93D, PHE104C, PHE114D, PRO101C, PRO112D, PRO66C, PRO67C, PRO77C, PRO89C, PRO89D, SER116D, SER82C, SER86C, SER86D, SER92C, SER92D, SER99C, THR103C, THR15D, THR16D, THR48D, THR79C, TRP19D, TRP30D, VAL102C, VAL113D, VAL17D, VAL62C, VAL78C, VAL87C, VAL87D, VAL91C, VAL91D, VAL94C, VAL94D, VAL96C
• A-C: LEU88A, LEU88C, PRO89C, VAL87A, VAL87C
• H-I: ALA108I, ALA55H, ALA81I, ALA85H, ALA85I, ARG107I, ARG120H, ARG43I, ARG61I, CYS21H, CYS50H, GLN118H, GLN84H, GLN84I, GLN97I, GLU22H, GLU53H, GLU57H, GLU58I, GLU63I, GLY109I, GLY117H, GLY20H, GLY52H, GLY95H, GLY95I, HIS47H, HIS47I, HIS60I, ILE49H, ILE49I, ILE64I, ILE80I, LEU115H, LEU18H, LEU45H, LEU46H, LEU46I, LEU51H, LEU51I, LEU65I, LEU83H, LEU83I, LEU88H, LEU88I, LEU98I, LYS54H, LYS56H, MET59I, MET90H, MET90I, MET93H, MET93I, PHE104I, PHE114H, PRO101I, PRO112H, PRO66I, PRO67I, PRO77I, PRO89H, PRO89I, SER116H, SER82I, SER86H, SER86I, SER92H, SER92I, SER99I, THR103I, THR15H, THR16H, THR48H, THR79I, TRP19H, VAL102I, VAL113H, VAL17H, VAL62I, VAL78I, VAL87H, VAL87I, VAL91H, VAL91I, VAL94H, VAL94I, VAL96I
• H-J: LEU88H, LEU88J, SER86H, VAL87H, VAL87J
• H-F: LEU88F, LEU88H, SER86F, VAL87F, VAL87H
• H-G: ALA108H, ALA55G, ALA81H, ALA85G, ALA85H, ARG107H, ARG120G, ARG43H, ARG61H, CYS21G, CYS50G, GLN118G, GLN76H, GLN84G, GLN84H, GLN97H, GLU119G, GLU22G, GLU53G, GLU58H, GLU63H, GLY109H, GLY117G, GLY20G, GLY52G, GLY95G, GLY95H, HIS47G, HIS47H, HIS60H, ILE49G, ILE49H, ILE64H, ILE80H, LEU115G, LEU18G, LEU44H, LEU45G, LEU46G, LEU46H, LEU51G, LEU51H, LEU65H, LEU83G, LEU83H, LEU88G, LEU88H, LEU98H, LYS54G, MET59H, MET90G, MET90H, MET93G, MET93H, PHE104H, PHE114G, PRO100H, PRO101H, PRO112G, PRO66H, PRO77H, PRO89G, PRO89H, SER116G, SER82H, SER86G, SER86H, SER92G, SER92H, SER99H, THR103H, THR15G, THR16G, THR48G, THR79H, TRP19G, VAL102H, VAL113G, VAL17G, VAL62H, VAL78H, VAL87G, VAL87H, VAL91G, VAL91H, VAL94G, VAL94H, VAL96H
• I-J: ALA108J, ALA55I, ALA68J, ALA81J, ALA85I, ALA85J, ARG107J, ARG120I, ARG27I, ARG43J, ARG61J, CYS21I, CYS50I, GLN118I, GLN76J, GLN84I, GLN84J, GLN97J, GLU119I, GLU22I, GLU53I, GLU57I, GLU58J, GLU63J, GLY109J, GLY117I, GLY20I, GLY52I, GLY95I, GLY95J, HIS47I, HIS47J, HIS60J, ILE49I, ILE49J, ILE64J, ILE80J, LEU115I, LEU18I, LEU44J, LEU45I, LEU46I, LEU46J, LEU51I, LEU51J, LEU65J, LEU83I, LEU83J, LEU88I, LEU88J, LEU98J, LYS54I, MET59J, MET90I, MET90J, MET93I, MET93J, PHE114I, PRO101J, PRO112I, PRO66J, PRO67J, PRO77J, PRO89I, PRO89J, SER116I, SER82J, SER86I, SER86J, SER92I, SER92J, SER99J, THR103J, THR15I, THR16I, THR48I, THR79J, TRP19I, TRP30I, VAL102J, VAL113I, VAL17I, VAL62J, VAL78J, VAL87I, VAL87J, VAL91I, VAL91J, VAL94I, VAL94J, VAL96J
• I-F: LEU88F, LEU88I, VAL87F, VAL87I
• I-G: LEU88G, LEU88I, VAL87G, VAL87I
• J-F: ALA108F, ALA55J, ALA81F, ALA85F, ALA85J, ARG107F, ARG120F, ARG120J, ARG43F, ARG61F, CYS21J, CYS50J, GLN118J, GLN76F, GLN84F, GLN84J, GLN97F, GLU119J, GLU22J, GLU53J, GLU57J, GLU58F, GLU63F, GLY109F, GLY117J, GLY20J, GLY52J, GLY95F, GLY95J, HIS47F, HIS47J, HIS60F, ILE49F, ILE49J, ILE64F, ILE80F, LEU115J, LEU18J, LEU44F, LEU45J, LEU46F, LEU46J, LEU51F, LEU51J, LEU65F, LEU83F, LEU83J, LEU88F, LEU88J, LEU98F, LYS54J, MET59F, MET90F, MET90J, MET93F, MET93J, PHE104F, PHE114J, PRO112J, PRO66F, PRO67F, PRO77F, PRO89F, PRO89J, SER116J, SER82F, SER86F, SER86J, SER92F, SER92J, SER99F, THR103F, THR15J, THR16J, THR48J, THR79F, TRP19J, VAL102F, VAL113J, VAL17J, VAL62F, VAL78F, VAL87F, VAL87J, VAL91F, VAL91J, VAL94F, VAL94J, VAL96F
• J-G: LEU88G, LEU88J, VAL87G, VAL87J
• F-G: ALA108G, ALA55F, ALA81G, ALA85F, ALA85G, ARG107G, ARG43G, ARG61G, CYS21F, CYS50F, GLN118F, GLN76G, GLN84F, GLN84G, GLN97G, GLU22F, GLU53F, GLU57F, GLU58G, GLU63G, GLY109G, GLY117F, GLY20F, GLY52F, GLY95F, GLY95G, HIS47F, HIS47G, HIS60G, ILE49F, ILE49G, ILE64G, ILE80G, LEU115F, LEU18F, LEU44G, LEU45F, LEU46F, LEU46G, LEU51F, LEU51G, LEU65G, LEU83F, LEU83G, LEU88F, LEU88G, LEU98G, LYS54F, LYS56F, MET59G, MET75G, MET90F, MET90G, MET93F, MET93G, PHE104G, PHE114F, PRO101G, PRO112F, PRO66G, PRO67G, PRO77G, PRO89F, PRO89G, SER116F, SER82G, SER86F, SER86G, SER92F, SER92G, SER99G, THR103G, THR16F, THR48F, THR79G, TRP19F, TRP30F, VAL102G, VAL113F, VAL17F, VAL62G, VAL78G, VAL87F, VAL87G, VAL91F, VAL91G, VAL94F, VAL94G, VAL96G