3STJ

crystal structure of the protease + pdz1 domain of degq from escherichia coli

• Total interactions analyzed: 300
• Total true interactions: 35
• Strongest Interaction:
  • Chains: D-F
  • Int. Res.: 118
  • Norm. En. per Res.: -3.5363
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-70.6582	-31.1603	-303.984	-405.8025	115	15	10	11783	3	12	13
A-C	-71.266	-30.0204	-296.002	-397.2885	115	23	9	11740	3	12	13
A-K	-22.5106	3.1069	-43.2974	-62.7011	57	4	0	2553	0	16	13
A-M	-20.5629	0.0	-73.4379	-94.0008	33	4	0	3120	0	0	0
A-Z	-31.035	0.0	-85.851	-116.886	46	8	0	3999	0	0	0
B-C	-58.162	-27.9181	-300.921	-387.0011	117	20	9	11765	2	13	14
B-E	-25.8006	2.8929	-49.314	-72.2217	61	3	0	2655	0	16	14
B-N	-33.55	0.0	-74.9479	-108.4979	34	7	0	3140	0	0	0
C-I	-14.9155	-4.0802	-41.0032	-59.999	46	5	0	2225	0	11	12
C-O	-17.509	0.0	-73.11	-90.619	36	2	0	3160	0	0	0
C-Z	0.0	0.0	-11.513	-11.513	13	0	0	582	0	0	0
D-E	-56.7729	-31.0285	-298.652	-386.4534	115	18	9	11698	3	12	14
D-F	-69.629	-33.6624	-313.992	-417.2834	118	23	9	11949	3	12	14
D-G	-6.0361	3.9231	-18.5528	-20.6658	44	0	0	1420	0	8	10
D-J	0.0	0.0	-1.5975	-1.5975	8	0	0	124	0	4	3
D-P	-33.5306	0.0	-78.4771	-112.0077	34	3	0	3229	0	0	0
E-F	-74.2294	-32.0472	-303.293	-409.5697	117	14	10	11748	3	12	13
E-Q	-23.6757	0.0	-74.2605	-97.9362	33	4	0	3114	0	0	0
F-J	-22.4956	-25.8605	-23.3405	-71.6966	42	3	0	1117	4	9	12
F-K	0.0	0.0	-0.4667	-0.4667	4	0	0	62	0	3	3
F-R	-29.1898	0.0	-71.5191	-100.7089	35	4	0	3133	0	0	0
G-H	-59.2477	-29.1196	-301.69	-390.0574	114	15	9	11634	2	13	14
G-I	-62.5545	-31.9489	-293.233	-387.7365	117	17	9	11711	3	12	14
G-K	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
G-S	-29.1252	0.0	-70.4942	-99.6194	36	4	0	3093	0	0	0
H-I	-59.847	-31.6517	-298.035	-389.5337	119	18	9	11755	3	12	14
H-L	-14.3512	4.0122	-38.8961	-49.2351	51	2	0	2147	0	10	12
H-T	-31.0532	0.0	-79.3451	-110.3983	34	12	0	3454	0	0	0
I-U	-42.7278	0.0	-72.2427	-114.9705	34	6	0	3085	0	0	0
J-K	-77.0886	-31.365	-301.97	-410.4236	118	15	10	11699	3	12	14
J-L	-64.1164	-30.9927	-298.459	-393.5681	115	15	9	11723	3	12	14
J-V	-33.7371	0.0	-73.0186	-106.7557	34	4	0	3126	0	0	0
K-L	-70.3458	-30.2247	-300.399	-400.9695	114	17	9	11659	3	12	14
K-W	-35.7159	0.0	-74.4287	-110.1446	34	5	0	3160	0	0	0
L-X	-21.4313	0.0	-75.2007	-96.632	34	3	0	3126	0	0	0

Interface residues

• A-B: ALA141A, ALA143A, ALA154A, ALA161B, ALA16A, ALA180A, ALA180B, ALA207A, ALA207B, ALA251B, ALA254B, ARG136B, ARG164B, ARG184A, ARG263B, ARG98A, ASN120A, ASN146A, ASN183A, ASN186A, ASN193B, ASN195B, ASN296B, ASN95A, ASP101A, ASP139B, ASP179A, ASP179B, ASP252B, ASP260B, ASP96A, GLN152A, GLN177B, GLN262B, GLN93A, GLU197B, GLU20A, GLU99A, GLY138B, GLY145A, GLY149A, GLY151A, GLY157A, GLY157B, GLY166B, GLY196B, GLY209A, GLY209B, GLY210A, GLY211A, GLY211B, GLY214A, GLY214B, GLY216B, GLY97A, ILE158B, ILE182A, ILE199B, ILE205A, ILE215B, ILE92A, LEU12A, LEU135B, LEU150A, LEU15A, LEU15B, LEU162B, LEU167B, LEU169B, LEU194A, LEU194B, LEU19A, LEU206B, LEU23A, LEU259B, LEU94A, LYS123A, LYS21A, LYS255B, MET18A, MET18B, MET249B, PHE100A, PHE140A, PHE140B, PHE148A, PHE175B, PHE217B, PRO11A, PRO13A, PRO13B, PRO147A, PRO17A, PRO208B, SER122A, SER14A, SER156A, SER156B, SER160B, SER165B, SER181A, SER181B, SER212A, SER212B, SER250B, THR153A, THR155A, THR178B, VAL137B, VAL142A, VAL144A, VAL159B, VAL213A, VAL213B, VAL261B
• A-C: ALA130A, ALA141C, ALA143C, ALA154C, ALA161A, ALA16C, ALA180A, ALA180C, ALA207A, ALA207C, ALA251A, ALA254A, ARG136A, ARG164A, ARG184C, ARG263A, ARG30C, ARG98C, ASN120C, ASN146C, ASN183C, ASN186C, ASN193A, ASN195A, ASN296A, ASN95C, ASP101C, ASP139A, ASP179A, ASP179C, ASP252A, ASP260A, ASP96C, GLN152C, GLN177A, GLN262A, GLN93C, GLU197A, GLU20C, GLU99C, GLY138A, GLY145C, GLY149C, GLY151C, GLY157A, GLY157C, GLY166A, GLY196A, GLY209A, GLY209C, GLY210C, GLY211A, GLY211C, GLY214A, GLY214C, GLY216A, GLY97C, ILE158A, ILE182C, ILE199A, ILE205C, ILE215A, ILE92C, LEU12C, LEU135A, LEU150C, LEU15A, LEU15C, LEU162A, LEU167A, LEU169A, LEU194A, LEU194C, LEU19C, LEU206A, LEU23C, LEU259A, LEU94C, LYS123C, LYS21C, LYS255A, MET18A, MET18C, MET249A, PHE100C, PHE140A, PHE140C, PHE148C, PHE217A, PRO11C, PRO13A, PRO13C, PRO147C, PRO17C, PRO208A, SER14C, SER156A, SER156C, SER160A, SER165A, SER181A, SER181C, SER212A, SER212C, SER250A, THR153C, THR155C, THR178A, VAL137A, VAL142C, VAL144C, VAL159A, VAL213A, VAL213C, VAL261A
• A-K: ALA72A, ALA72K, ARG98A, ASN120A, ASN120K, ASN291A, ASN71A, ASP233A, ASP233K, GLN117K, GLN119K, GLN126A, GLN126K, GLN229A, GLN229K, GLU309K, GLU326A, GLU326K, GLU328A, GLU328K, GLY311K, GLY75A, ILE118A, ILE232A, LEU124A, LEU124K, LEU331K, LYS123A, LYS123K, LYS134A, LYS134K, LYS21A, LYS238K, LYS313A, LYS313K, LYS315A, LYS315K, LYS74A, LYS74K, PHE100A, PHE100K, PHE234K, PRO121A, PRO121K, PRO310K, SER122A, SER122K, SER73A, SER73K, THR125A, THR308A, THR312A, THR312K, THR330K, VAL314K, VAL327K, VAL329K
• A-M: ALA265A, ALA299A, ALA306A, ARG302A, ASP332A, GLU248A, GLU269A, GLY240A, GLY243A, GLY246A, ILE244A, ILE287A, ILE305A, LEU241A, LEU242A, LEU271A, LEU301A, LEU331A, LYS245A, PHE266A, PHE298A, SER268A, SER274A, SER276A, SER303A, SER334A, THR247A, UNK401M, UNK402M, UNK403M, UNK404M, UNK405M, VAL267A
• A-Z: ALA204A, ALA207A, ARG184A, ASN146A, ASN168A, ASN183A, ASN186A, ASN202A, ASN80A, ASP112A, GLU170A, GLU173A, GLY185A, GLY188A, GLY189A, GLY209A, GLY210A, GLY211A, GLY216A, GLY65A, HIS82A, ILE182A, ILE205A, ILE215A, LEU167A, LEU169A, LEU206A, LEU64A, PHE148A, PHE175A, PHE217A, PRO147A, PRO208A, SER187A, SER212A, SER66A, THR203A, UNK0Z, UNK1Z, UNK2Z, UNK3Z, UNK4Z, UNK5Z, UNK6Z, VAL213A, VAL83A
• B-C: ALA141B, ALA143B, ALA154B, ALA161C, ALA16B, ALA180B, ALA180C, ALA207B, ALA207C, ALA251C, ALA254C, ARG136C, ARG164C, ARG184B, ARG263C, ARG30B, ARG98B, ASN120B, ASN146B, ASN183B, ASN186B, ASN193C, ASN195C, ASN296C, ASN95B, ASP101B, ASP139C, ASP179B, ASP179C, ASP252C, ASP260C, ASP96B, GLN119B, GLN152B, GLN177C, GLN262C, GLN93B, GLU197C, GLU20B, GLU99B, GLY138C, GLY145B, GLY149B, GLY151B, GLY157B, GLY157C, GLY166C, GLY196C, GLY209B, GLY209C, GLY210B, GLY211B, GLY211C, GLY214B, GLY214C, GLY216C, GLY97B, ILE118B, ILE158C, ILE182B, ILE199C, ILE205B, ILE215C, LEU12B, LEU135C, LEU150B, LEU15B, LEU15C, LEU162C, LEU167C, LEU169C, LEU194B, LEU194C, LEU19B, LEU206C, LEU23B, LEU259C, LEU94B, LYS123B, LYS21B, LYS255C, MET18B, MET18C, MET249C, PHE100B, PHE140B, PHE140C, PHE148B, PHE217C, PRO11B, PRO13B, PRO13C, PRO147B, PRO17B, PRO208B, PRO208C, SER122B, SER14B, SER156B, SER156C, SER160C, SER165C, SER181B, SER181C, SER212B, SER212C, SER250C, THR153B, THR155B, THR178C, VAL137C, VAL142B, VAL144B, VAL159C, VAL213B, VAL213C, VAL261C
• B-E: ALA72B, ALA72E, ARG225E, ARG98E, ASN120B, ASN120E, ASN291E, ASN71E, ASP233B, ASP233E, GLN117B, GLN119B, GLN126B, GLN126E, GLN229B, GLN229E, GLU309B, GLU326B, GLU326E, GLU328B, GLU328E, GLY311B, GLY75B, GLY75E, ILE118B, ILE118E, ILE232B, ILE232E, LEU124B, LEU124E, LEU331B, LYS123B, LYS123E, LYS134B, LYS134E, LYS21E, LYS238B, LYS313B, LYS313E, LYS315B, LYS315E, LYS74B, LYS74E, PHE100B, PHE100E, PHE234B, PRO121B, PRO121E, PRO310B, SER122B, SER122E, SER73B, SER73E, THR125E, THR308E, THR312B, THR312E, THR330B, VAL314B, VAL327B, VAL329B
• B-N: ALA265B, ALA299B, ALA306B, ARG302B, ASP332B, GLU248B, GLU269B, GLY240B, GLY243B, GLY246B, ILE244B, ILE287B, ILE305B, LEU172B, LEU241B, LEU242B, LEU271B, LEU301B, LEU331B, LYS245B, PHE266B, PHE298B, SER268B, SER274B, SER276B, SER303B, SER334B, THR247B, UNK401N, UNK402N, UNK403N, UNK404N, UNK405N, VAL267B
• C-I: ALA72I, ARG98I, ASN120C, ASN120I, ASN291I, ASN71I, ASP233C, ASP233I, GLN126I, GLN229I, GLU309C, GLU326C, GLU328C, GLU328I, GLY311C, GLY75I, ILE118I, ILE232I, LEU124I, LEU331C, LYS123C, LYS123I, LYS134C, LYS21I, LYS313C, LYS313I, LYS315C, LYS315I, LYS74C, LYS74I, PHE100I, PHE234C, PRO121C, PRO121I, PRO310C, SER122C, SER122I, SER73C, SER73I, THR125I, THR312C, THR312I, THR330C, VAL314C, VAL327C, VAL329C
• C-O: ALA265C, ALA299C, ALA306C, ARG239C, ARG302C, ARG304C, ASP332C, GLU248C, GLU269C, GLY240C, GLY243C, GLY246C, ILE244C, ILE287C, ILE305C, LEU172C, LEU241C, LEU242C, LEU271C, LEU301C, LEU331C, LYS245C, PHE266C, PHE298C, SER268C, SER274C, SER276C, SER303C, SER334C, THR247C, UNK401O, UNK402O, UNK403O, UNK404O, UNK405O, VAL267C
• C-Z: ARG184C, ASN183C, GLY149C, GLY185C, GLY210C, GLY211C, LEU150C, PHE148C, PRO147C, UNK0Z, UNK1Z, UNK2Z, UNK3Z
• D-E: ALA130E, ALA141D, ALA143D, ALA154D, ALA161E, ALA16D, ALA180D, ALA180E, ALA207D, ALA207E, ALA251E, ALA254E, ARG136E, ARG164E, ARG184D, ARG263E, ARG98D, ASN120D, ASN146D, ASN183D, ASN186D, ASN193E, ASN195E, ASN296E, ASN95D, ASP101D, ASP139E, ASP179D, ASP179E, ASP252E, ASP260E, ASP96D, GLN119D, GLN152D, GLN177E, GLN262E, GLN93D, GLU197E, GLU20D, GLU99D, GLY138E, GLY145D, GLY149D, GLY151D, GLY157D, GLY157E, GLY166E, GLY196E, GLY209D, GLY209E, GLY210D, GLY211D, GLY211E, GLY214D, GLY214E, GLY216E, GLY97D, ILE158E, ILE182D, ILE199E, ILE205D, ILE215E, ILE92D, LEU12D, LEU135E, LEU150D, LEU15D, LEU15E, LEU162E, LEU167E, LEU169E, LEU194D, LEU194E, LEU19D, LEU206E, LEU23D, LEU259E, LEU94D, LYS123D, LYS21D, LYS255E, MET18D, MET18E, MET249E, PHE100D, PHE140D, PHE140E, PHE148D, PHE217E, PRO11D, PRO13D, PRO13E, PRO147D, PRO17D, PRO208E, SER14D, SER156D, SER156E, SER160E, SER165E, SER181D, SER181E, SER212D, SER212E, SER250E, THR153D, THR155D, THR178E, VAL137E, VAL142D, VAL144D, VAL159E, VAL213D, VAL213E, VAL261E
• D-F: ALA130D, ALA141F, ALA143F, ALA154F, ALA161D, ALA16F, ALA180D, ALA180F, ALA207D, ALA207F, ALA251D, ALA254D, ARG136D, ARG164D, ARG184F, ARG263D, ARG30F, ARG98F, ASN120F, ASN146F, ASN183F, ASN186F, ASN193D, ASN195D, ASN296D, ASN95F, ASP101F, ASP139D, ASP179D, ASP179F, ASP252D, ASP260D, ASP96F, GLN119F, GLN152F, GLN177D, GLN262D, GLN93F, GLU197D, GLU20F, GLU99F, GLY138D, GLY145F, GLY149F, GLY151F, GLY157D, GLY157F, GLY166D, GLY196D, GLY209D, GLY209F, GLY210F, GLY211D, GLY211F, GLY214D, GLY214F, GLY216D, GLY97F, ILE158D, ILE182F, ILE199D, ILE205F, ILE215D, ILE92F, LEU12F, LEU135D, LEU150F, LEU15D, LEU15F, LEU162D, LEU167D, LEU169D, LEU194D, LEU194F, LEU19F, LEU206D, LEU23F, LEU259D, LEU94F, LYS123F, LYS134D, LYS21F, LYS255D, MET18D, MET18F, MET249D, PHE100F, PHE140D, PHE140F, PHE148F, PHE217D, PRO11F, PRO13D, PRO13F, PRO147F, PRO17F, PRO208D, PRO208F, SER14F, SER156D, SER156F, SER160D, SER165D, SER181D, SER181F, SER212D, SER212F, SER250D, THR153F, THR155F, THR178D, VAL137D, VAL142F, VAL144F, VAL159D, VAL213D, VAL213F, VAL261D
• D-G: ARG98D, ARG98G, ASN120D, ASN120G, ASN71G, ASP233D, ASP233G, GLN229D, GLN229G, GLN230D, GLN230G, GLU309D, GLU309G, GLU326D, GLU328D, GLU328G, GLY311D, ILE232D, ILE232G, LEU124G, LYS123D, LYS123G, LYS238D, LYS313D, LYS313G, LYS315D, LYS315G, LYS74D, LYS74G, PHE100G, PHE234D, PHE234G, PRO121D, PRO121G, PRO310D, SER122D, SER122G, SER73D, SER73G, THR312D, THR312G, THR330D, THR330G, TYR76G
• D-J: ASN258D, ASP260D, GLU326J, GLU328J, LEU325J, LYS313J, LYS315J, LYS323D
• D-P: ALA265D, ALA299D, ALA306D, ARG302D, ASP332D, GLU248D, GLU269D, GLY240D, GLY243D, GLY246D, ILE244D, ILE287D, ILE305D, LEU172D, LEU241D, LEU242D, LEU271D, LEU301D, LEU331D, LYS245D, PHE266D, PHE298D, SER268D, SER274D, SER276D, SER303D, SER334D, THR247D, UNK401P, UNK402P, UNK403P, UNK404P, UNK405P, VAL267D
• E-F: ALA130F, ALA141E, ALA143E, ALA154E, ALA161F, ALA16E, ALA180E, ALA180F, ALA207E, ALA207F, ALA251F, ALA254F, ARG136F, ARG164F, ARG184E, ARG263F, ARG98E, ASN120E, ASN146E, ASN183E, ASN186E, ASN193F, ASN195F, ASN296F, ASN95E, ASP101E, ASP139F, ASP179E, ASP179F, ASP252F, ASP260F, ASP96E, GLN119E, GLN152E, GLN177F, GLN262F, GLN93E, GLU197F, GLU20E, GLU99E, GLY138F, GLY145E, GLY149E, GLY151E, GLY157E, GLY157F, GLY166F, GLY196F, GLY209E, GLY209F, GLY210E, GLY211E, GLY211F, GLY214E, GLY214F, GLY216F, GLY97E, ILE158F, ILE182E, ILE199F, ILE205E, ILE215F, ILE92E, LEU12E, LEU135F, LEU150E, LEU15E, LEU15F, LEU162F, LEU167F, LEU169F, LEU194E, LEU194F, LEU19E, LEU206F, LEU23E, LEU259F, LEU94E, LYS123E, LYS134F, LYS21E, LYS255F, MET18E, MET18F, MET249F, PHE100E, PHE140E, PHE140F, PHE148E, PHE217F, PRO11E, PRO13E, PRO147E, PRO17E, PRO208E, PRO208F, SER122E, SER14E, SER156E, SER156F, SER160F, SER165F, SER181E, SER181F, SER212E, SER212F, SER250F, THR153E, THR155E, THR178F, VAL137F, VAL142E, VAL144E, VAL159F, VAL213E, VAL213F, VAL261F
• E-Q: ALA265E, ALA299E, ALA306E, ARG302E, ASP332E, GLU248E, GLU269E, GLY240E, GLY243E, GLY246E, ILE244E, ILE287E, ILE305E, LEU241E, LEU242E, LEU271E, LEU301E, LEU331E, LYS245E, PHE266E, PHE298E, SER268E, SER274E, SER276E, SER303E, SER334E, THR247E, UNK401Q, UNK402Q, UNK403Q, UNK404Q, UNK405Q, VAL267E
• F-J: ARG225F, ARG225J, ASN120F, ASN120J, ASN291J, ASN71F, ASN71J, ASP233F, ASP233J, GLN126F, GLN229F, GLN229J, GLN230F, GLN230J, GLU309F, GLU309J, GLU328J, GLY311F, GLY311J, ILE232F, ILE232J, LYS123F, LYS123J, LYS313F, LYS313J, LYS315F, LYS315J, LYS74F, LYS74J, PHE234F, PHE234J, PRO121F, SER122F, SER122J, SER73F, SER73J, THR226F, THR226J, THR312F, THR312J, TYR76F, TYR76J
• F-K: ASN258K, ASP260K, GLU328F, LYS315F
• F-R: ALA265F, ALA299F, ALA306F, ARG239F, ARG302F, ASP332F, GLU248F, GLU269F, GLY240F, GLY243F, GLY246F, ILE244F, ILE287F, ILE305F, LEU172F, LEU241F, LEU242F, LEU271F, LEU301F, LEU331F, LYS245F, PHE266F, PHE298F, SER268F, SER274F, SER276F, SER303F, SER334F, THR247F, UNK401R, UNK402R, UNK403R, UNK404R, UNK405R, VAL267F
• G-H: ALA141G, ALA143G, ALA154G, ALA161H, ALA16G, ALA180G, ALA180H, ALA207G, ALA207H, ALA251H, ALA254H, ARG136H, ARG164H, ARG184G, ARG263H, ARG30G, ARG98G, ASN120G, ASN146G, ASN183G, ASN186G, ASN193H, ASN195H, ASN296H, ASN95G, ASP101G, ASP139H, ASP179G, ASP179H, ASP252H, ASP260H, ASP96G, GLN152G, GLN177H, GLN262H, GLN93G, GLU197H, GLU20G, GLU99G, GLY138H, GLY145G, GLY149G, GLY151G, GLY157G, GLY157H, GLY166H, GLY196H, GLY209G, GLY209H, GLY210G, GLY210H, GLY211G, GLY211H, GLY214G, GLY214H, GLY216H, GLY97G, ILE158H, ILE182G, ILE205G, ILE215H, ILE92G, LEU12G, LEU135H, LEU150G, LEU15G, LEU15H, LEU162H, LEU167H, LEU169H, LEU194G, LEU194H, LEU19G, LEU206H, LEU23G, LEU259H, LEU94G, LYS123G, LYS21G, LYS255H, MET18G, MET18H, MET249H, PHE100G, PHE140G, PHE140H, PHE148G, PHE217H, PRO11G, PRO13G, PRO13H, PRO147G, PRO17G, PRO208H, SER14G, SER156G, SER156H, SER160H, SER165H, SER181G, SER181H, SER212G, SER212H, SER250H, THR153G, THR155G, THR178H, VAL137H, VAL142G, VAL144G, VAL159H, VAL213G, VAL213H, VAL261H
• G-I: ALA130G, ALA141I, ALA143I, ALA154I, ALA161G, ALA16I, ALA180G, ALA180I, ALA207G, ALA207I, ALA251G, ALA254G, ARG136G, ARG164G, ARG184I, ARG263G, ARG98I, ASN120I, ASN146I, ASN183I, ASN186I, ASN193G, ASN195G, ASN296G, ASN95I, ASP101I, ASP139G, ASP179G, ASP179I, ASP252G, ASP260G, ASP96I, GLN152I, GLN177G, GLN262G, GLN93I, GLU197G, GLU20I, GLU99I, GLY138G, GLY145I, GLY149I, GLY151I, GLY157G, GLY157I, GLY166G, GLY196G, GLY209G, GLY209I, GLY210I, GLY211G, GLY211I, GLY214G, GLY214I, GLY216G, GLY97I, ILE158G, ILE182I, ILE199G, ILE205I, ILE215G, ILE92I, LEU12I, LEU135G, LEU150I, LEU15G, LEU15I, LEU162G, LEU167G, LEU169G, LEU194G, LEU194I, LEU19I, LEU206G, LEU23I, LEU259G, LEU94I, LYS123I, LYS134G, LYS21I, LYS255G, MET18G, MET18I, MET249G, PHE100I, PHE140G, PHE140I, PHE148I, PHE217G, PRO11I, PRO13G, PRO13I, PRO147I, PRO17I, PRO208G, PRO208I, SER122I, SER14I, SER156G, SER156I, SER160G, SER165G, SER181G, SER181I, SER212G, SER212I, SER250G, THR153I, THR155I, THR178G, VAL137G, VAL142I, VAL144I, VAL159G, VAL213G, VAL213I, VAL261G
• G-K: PRO11G, PRO11K
• G-S: ALA265G, ALA299G, ALA306G, ARG239G, ARG302G, ARG304G, ASP332G, GLU248G, GLU269G, GLY240G, GLY243G, GLY246G, ILE244G, ILE287G, ILE305G, LEU172G, LEU241G, LEU242G, LEU271G, LEU301G, LEU331G, LYS245G, PHE266G, PHE298G, SER268G, SER274G, SER276G, SER303G, SER334G, THR247G, UNK401S, UNK402S, UNK403S, UNK404S, UNK405S, VAL267G
• H-I: ALA130I, ALA141H, ALA143H, ALA154H, ALA161I, ALA16H, ALA180H, ALA180I, ALA207H, ALA207I, ALA251I, ALA254I, ARG136I, ARG164I, ARG184H, ARG263I, ARG30H, ARG98H, ASN120H, ASN146H, ASN183H, ASN186H, ASN193I, ASN195I, ASN296I, ASN95H, ASP101H, ASP139I, ASP179H, ASP179I, ASP252I, ASP260I, ASP96H, GLN152H, GLN177I, GLN262I, GLN93H, GLU197I, GLU20H, GLU99H, GLY138I, GLY145H, GLY149H, GLY151H, GLY157H, GLY157I, GLY166I, GLY196I, GLY209H, GLY209I, GLY210H, GLY210I, GLY211H, GLY211I, GLY214H, GLY214I, GLY216I, GLY97H, ILE158I, ILE182H, ILE199I, ILE205H, ILE205I, ILE215I, ILE92H, LEU12H, LEU135I, LEU150H, LEU15H, LEU15I, LEU162I, LEU167I, LEU169I, LEU194H, LEU194I, LEU19H, LEU206I, LEU23H, LEU259I, LEU94H, LYS123H, LYS21H, LYS255I, MET18H, MET18I, MET249I, PHE100H, PHE140H, PHE140I, PHE148H, PHE175I, PHE217I, PRO11H, PRO13H, PRO13I, PRO147H, PRO17H, PRO208H, PRO208I, SER14H, SER156H, SER156I, SER160I, SER165I, SER181H, SER181I, SER212H, SER212I, SER250I, THR153H, THR155H, THR178I, VAL137I, VAL142H, VAL144H, VAL159I, VAL213H, VAL213I, VAL261I
• H-L: ALA72H, ALA72L, ARG98L, ASN120H, ASN120L, ASN291L, ASN71L, ASP233H, ASP233L, GLN126L, GLN229L, GLU309H, GLU326H, GLU328H, GLU328L, GLY311H, GLY311L, GLY75L, ILE118L, ILE232L, LEU124H, LEU124L, LEU331H, LYS123H, LYS123L, LYS134H, LYS21L, LYS238H, LYS313H, LYS313L, LYS315H, LYS315L, LYS74H, LYS74L, PHE100L, PHE234H, PRO121H, PRO121L, PRO310H, SER122H, SER122L, SER73H, SER73L, THR125L, THR312H, THR312L, THR330H, VAL314H, VAL314L, VAL327H, VAL329H
• H-T: ALA265H, ALA299H, ALA306H, ARG239H, ARG302H, ASP332H, GLU248H, GLU269H, GLY240H, GLY243H, GLY246H, ILE244H, ILE287H, ILE305H, LEU172H, LEU241H, LEU242H, LEU271H, LEU301H, LEU331H, LYS245H, PHE266H, PHE298H, SER268H, SER276H, SER303H, SER334H, THR247H, UNK401T, UNK402T, UNK403T, UNK404T, UNK405T, VAL267H
• I-U: ALA265I, ALA299I, ALA306I, ARG302I, ASP332I, GLU248I, GLU269I, GLY240I, GLY243I, GLY246I, ILE244I, ILE287I, ILE305I, LEU241I, LEU242I, LEU271I, LEU301I, LEU316I, LEU331I, LYS245I, PHE266I, PHE298I, SER268I, SER274I, SER276I, SER303I, SER334I, THR247I, UNK401U, UNK402U, UNK403U, UNK404U, UNK405U, VAL267I
• J-K: ALA130K, ALA141J, ALA143J, ALA154J, ALA161K, ALA16J, ALA180J, ALA180K, ALA207J, ALA207K, ALA251K, ALA254K, ARG136K, ARG164K, ARG184J, ARG263K, ARG30J, ARG98J, ASN120J, ASN146J, ASN183J, ASN186J, ASN193K, ASN195K, ASN296K, ASN95J, ASP101J, ASP139K, ASP179J, ASP179K, ASP252K, ASP260K, ASP96J, GLN119J, GLN152J, GLN177K, GLN262K, GLN93J, GLU197K, GLU20J, GLU99J, GLY138K, GLY145J, GLY149J, GLY151J, GLY157J, GLY157K, GLY166K, GLY196K, GLY209J, GLY209K, GLY210J, GLY211J, GLY211K, GLY214J, GLY214K, GLY216K, GLY97J, ILE158K, ILE182J, ILE199K, ILE205J, ILE215K, ILE92J, LEU12J, LEU135K, LEU150J, LEU15J, LEU15K, LEU162K, LEU167K, LEU169K, LEU194J, LEU194K, LEU19J, LEU206K, LEU23J, LEU259K, LEU94J, LYS123J, LYS134K, LYS21J, LYS255K, MET18J, MET18K, MET249K, PHE100J, PHE140J, PHE140K, PHE148J, PHE175K, PHE217K, PRO11J, PRO13J, PRO13K, PRO147J, PRO17J, PRO208K, SER14J, SER156J, SER156K, SER160K, SER165K, SER181J, SER181K, SER212J, SER212K, SER250K, THR153J, THR155J, THR178K, VAL137K, VAL142J, VAL144J, VAL159K, VAL213J, VAL213K, VAL261K
• J-L: ALA141L, ALA143L, ALA154L, ALA161J, ALA16L, ALA180J, ALA180L, ALA207J, ALA207L, ALA251J, ALA254J, ARG136J, ARG164J, ARG184L, ARG263J, ARG98L, ASN120L, ASN146L, ASN183L, ASN186L, ASN193J, ASN195J, ASN258J, ASN296J, ASN95L, ASP101L, ASP139J, ASP179J, ASP179L, ASP252J, ASP260J, ASP96L, GLN119L, GLN152L, GLN177J, GLN262J, GLN93L, GLU197J, GLU20L, GLU99L, GLY138J, GLY145L, GLY149L, GLY151L, GLY157J, GLY157L, GLY166J, GLY196J, GLY209J, GLY209L, GLY210L, GLY211J, GLY211L, GLY214J, GLY214L, GLY216J, GLY97L, ILE158J, ILE182L, ILE199J, ILE205L, ILE215J, ILE92L, LEU12L, LEU135J, LEU150L, LEU15J, LEU15L, LEU162J, LEU167J, LEU169J, LEU194J, LEU194L, LEU19L, LEU206J, LEU23L, LEU259J, LEU94L, LYS123L, LYS21L, LYS255J, MET18J, MET18L, MET249J, PHE100L, PHE140J, PHE140L, PHE148L, PHE217J, PRO11L, PRO13J, PRO13L, PRO147L, PRO17L, PRO208J, SER14L, SER156J, SER156L, SER160J, SER165J, SER181J, SER181L, SER212J, SER212L, SER250J, THR153L, THR155L, THR178J, VAL137J, VAL142L, VAL144L, VAL159J, VAL213J, VAL213L, VAL261J
• J-V: ALA265J, ALA299J, ALA306J, ARG302J, ASP332J, GLU248J, GLU269J, GLY240J, GLY243J, GLY246J, ILE244J, ILE287J, ILE305J, LEU172J, LEU241J, LEU242J, LEU271J, LEU301J, LEU331J, LYS245J, PHE266J, PHE298J, SER268J, SER274J, SER276J, SER303J, SER334J, THR247J, UNK401V, UNK402V, UNK403V, UNK404V, UNK405V, VAL267J
• K-L: ALA141K, ALA143K, ALA154K, ALA161L, ALA16K, ALA180K, ALA180L, ALA207K, ALA207L, ALA251L, ALA254L, ARG136L, ARG164L, ARG184K, ARG263L, ARG98K, ASN120K, ASN146K, ASN183K, ASN186K, ASN193L, ASN195L, ASN296L, ASN95K, ASP101K, ASP139L, ASP179K, ASP179L, ASP252L, ASP260L, ASP96K, GLN152K, GLN177L, GLN262L, GLN93K, GLU197L, GLU20K, GLU99K, GLY138L, GLY145K, GLY149K, GLY151K, GLY157K, GLY157L, GLY166L, GLY196L, GLY209K, GLY209L, GLY210K, GLY211K, GLY211L, GLY214K, GLY214L, GLY216L, GLY97K, ILE158L, ILE182K, ILE199L, ILE205K, ILE215L, ILE92K, LEU12K, LEU135L, LEU150K, LEU15K, LEU15L, LEU162L, LEU167L, LEU169L, LEU194K, LEU194L, LEU19K, LEU206L, LEU23K, LEU259L, LEU94K, LYS123K, LYS21K, LYS255L, MET18K, MET18L, MET249L, PHE100K, PHE140K, PHE140L, PHE148K, PHE217L, PRO11K, PRO13K, PRO13L, PRO147K, PRO17K, PRO208L, SER122K, SER14K, SER156K, SER156L, SER160L, SER165L, SER181K, SER181L, SER212K, SER212L, SER250L, THR153K, THR155K, THR178L, VAL137L, VAL142K, VAL144K, VAL159L, VAL213K, VAL213L, VAL261L
• K-W: ALA265K, ALA299K, ALA306K, ARG302K, ASP332K, GLU248K, GLU269K, GLY240K, GLY243K, GLY246K, ILE244K, ILE287K, ILE305K, LEU241K, LEU242K, LEU271K, LEU301K, LEU316K, LEU331K, LYS245K, PHE266K, PHE298K, SER268K, SER274K, SER276K, SER303K, SER334K, THR247K, UNK401W, UNK402W, UNK403W, UNK404W, UNK405W, VAL267K
• L-X: ALA265L, ALA299L, ALA306L, ARG302L, ASP332L, GLU248L, GLU269L, GLY240L, GLY243L, GLY246L, ILE244L, ILE287L, ILE305L, LEU172L, LEU241L, LEU242L, LEU271L, LEU301L, LEU331L, LYS245L, PHE266L, PHE298L, SER268L, SER274L, SER276L, SER303L, SER334L, THR247L, UNK401X, UNK402X, UNK403X, UNK404X, UNK405X, VAL267L