3SRV

crystal structure of spleen tyrosine kinase (syk) in complex with a diaminopyrimidine carboxamide inhibitor

• Total interactions analyzed: 1
• Total true interactions: 1
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 67
  • Norm. En. per Res.: -2.1129
• Hub Node: A(1)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-37.4497	9.1524	-113.268	-141.5654	67	6	0	5607	0	33	29

Interface residues

• A-B: ARG367A, ARG434A, ARG574B, ARG590B, ARG599B, ARG616B, ARG625B, ASN606B, ASN615B, ASP366A, ASP374A, ASP603B, ASP612B, CYS593B, CYS608B, GLN391A, GLN505A, GLU373A, GLU449A, GLU452A, GLU586B, GLU589B, GLU600B, GLY388A, GLY588B, GLY592B, HIS506A, LEU369A, LEU370A, LEU372A, LEU377A, LEU453A, LEU585B, LEU604B, LEU607B, LYS368A, LYS375A, LYS387A, LYS393A, LYS394A, LYS397A, LYS587B, MET392A, MET450A, MET576B, MET584B, MET591B, MET605B, PRO617B, THR371A, THR398A, THR504A, THR610B, TRP556B, TRP563B, TRP609B, TYR389A, TYR390A, TYR507A, TYR546B, TYR573B, TYR602B, TYR611B, VAL395A, VAL396A, VAL399A, VAL503A