3SQG

crystal structure of a methyl-coenzyme m reductase purified from black sea mats

• Total interactions analyzed: 36
• Total true interactions: 21
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 431
  • Norm. En. per Res.: -6.0331
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-35.0201	-110.3174	-283.869	-429.2065	127	12	4	10910	11	21	25
A-C	-164.2861	-174.0867	-999.703	-1338.0759	247	47	18	36023	14	76	73
A-D	-437.7744	-226.912	-1935.57	-2600.2564	431	111	37	71454	26	132	135
A-E	-101.4101	-18.0508	-713.67	-833.1308	234	15	14	26085	0	29	25
A-F	-45.2355	-21.0804	-139.282	-205.5979	66	8	1	6698	4	32	36
A-G	-15.1819	-33.3148	-64.2308	-112.7275	53	2	0	2894	5	18	20
B-C	-195.1574	-133.5847	-802.976	-1131.7181	238	56	15	32460	12	76	61
B-D	-91.9411	-21.8984	-720.443	-834.2825	234	20	14	26160	1	29	25
B-E	-80.3798	33.0185	-433.218	-480.5793	178	20	9	19576	0	38	40
B-F	0.0	-2.9519	-52.5542	-55.5061	31	2	1	2327	0	2	3
C-D	-53.0246	-28.6502	-153.193	-234.8678	70	8	1	7050	4	32	36
C-E	0.0	-3.3368	-50.2724	-53.6092	31	0	1	2257	0	2	2
D-E	-31.01	-112.2833	-275.234	-418.5273	126	15	3	10846	11	21	25
D-F	-163.7754	-171.6886	-986.757	-1322.221	244	44	18	35745	13	76	75
D-G	-41.1873	18.7588	-311.829	-334.2575	164	15	6	13957	8	98	94
D-I	0.0	-0.9333	-8.721	-9.6543	8	1	0	328	0	2	3
E-F	-164.381	-128.011	-776.622	-1069.014	239	58	15	32202	12	76	60
F-G	0.0	0.263	-6.2363	-5.9733	7	0	0	303	0	2	3
G-H	-37.018	-73.8288	-273.625	-384.4718	126	13	3	10849	11	21	25
G-I	-182.5485	-154.7808	-1012.19	-1349.5193	248	47	18	35942	13	78	72
H-I	-186.9337	-120.3233	-780.623	-1087.88	239	61	15	32207	12	76	62

Interface residues

• A-B: ALA286A, ALA348B, ALA351B, ALA381B, ALA473A, ALA498A, ARG188B, ARG285A, ARG336B, ARG379B, ARG394A, ARG456A, ASN180B, ASN189B, ASN223B, ASN374B, ASN493A, ASN496A, ASN500A, ASP164B, ASP344B, ASP466A, ASP469A, ASP482A, CYS224B, CYS331B, CYS332B, CYS471A, CYS474A, GLN218B, GLN329B, GLN349B, GLN468A, GLN470A, GLN480A, GLU181B, GLU220B, GLU335B, GLU455A, GLU483A, GLY182B, GLY184B, GLY222B, GLY226B, GLY325B, GLY335A, GLY340A, GLY341A, GLY343A, GLY346B, GLY350B, GLY364B, GLY365B, GLY452A, GLY461A, GLY475A, GLY484A, HIS228B, HIS232B, HIS360B, HIS375B, HIS380B, HIS503A, ILE176B, ILE362B, ILE376B, LEU451A, LEU460A, LEU467A, LYS179B, LYS284A, LYS382B, MET178B, MET221B, MET225B, MET281A, MET283B, MET328B, MET338A, MET347B, PHE185B, PHE334A, PHE344A, PHE345B, PHE357B, PHE358B, PHE371B, PHE462A, PHE463A, PRO163B, PRO177B, PRO183B, PRO227B, PRO282A, PRO324B, PRO341B, PRO343B, PRO495A, SER339A, SER352B, SER354B, SER355B, SER356B, SER359B, SER361B, SER447A, SER476A, SER478A, SER481A, THR378B, THR472A, TYR280A, TYR347A, TYR363B, TYR372B, TYR454A, TYR465A, TYR479A, TYR494A, TYR497A, VAL283A, VAL342A, VAL353B, VAL370B, VAL377B, VAL492A, VAL501A
• A-C: ALA102C, ALA12C, ALA159C, ALA171C, ALA19A, ALA220C, ALA228C, ALA238C, ALA26A, ALA372A, ALA395A, ALA400A, ALA406A, ALA411A, ALA421A, ALA445A, ALA473A, ALA6C, ARG101C, ARG120C, ARG147C, ARG151C, ARG153C, ARG15C, ARG161C, ARG173C, ARG174C, ARG218C, ARG244C, ARG276C, ARG394A, ARG420A, ARG456A, ARG459A, ARG75A, ASN219C, ASN269C, ASN385A, ASN397A, ASN4A, ASN9A, ASP113C, ASP163C, ASP165C, ASP170C, ASP230C, ASP235C, ASP264C, ASP370A, ASP382A, ASP387A, ASP398A, ASP466A, ASP469A, ASP89C, CYS471A, CYS474A, GLN100C, GLN221C, GLN226C, GLN239C, GLN250C, GLN346A, GLN403A, GLN468A, GLN470A, GLN480A, GLN72A, GLN74A, GLN86C, GLU124C, GLU20A, GLU227C, GLU232C, GLU23A, GLU280C, GLU28A, GLU366A, GLU390A, GLU391A, GLU396A, GLU405A, GLU412A, GLU455A, GLU483A, GLY115C, GLY119C, GLY157C, GLY166C, GLY223C, GLY247C, GLY248C, GLY260C, GLY261C, GLY266C, GLY277C, GLY278C, GLY368A, GLY373A, GLY381A, GLY416A, GLY417A, GLY452A, GLY458A, GLY461A, GLY475A, GLY69A, GLY73A, GLY7C, HIS156C, HIS158C, HIS241C, HIS414A, HIS453A, ILE122C, ILE123C, ILE240C, ILE258C, ILE367A, ILE388A, ILE392A, ILE393A, ILE96C, LEU117C, LEU11A, LEU162C, LEU172C, LEU270C, LEU272C, LEU384A, LEU389A, LEU401A, LEU443A, LEU448A, LEU451A, LEU460A, LEU467A, LEU77A, LYS164C, LYS17A, LYS188C, LYS21A, LYS243C, LYS259C, LYS262C, LYS263C, LYS268C, LYS271C, LYS363A, LYS380A, LYS383A, MET14A, MET167C, MET168C, MET216C, MET234C, MET255C, MET386A, MET450A, MET70A, MET78A, MET91C, PHE10A, PHE169C, PHE18A, PHE249C, PHE273C, PHE29A, PHE415A, PHE462A, PHE463A, PHE92C, PHE93C, PRO114C, PRO22A, PRO231C, PRO251C, PRO275C, PRO2A, PRO408A, PRO441A, PRO71A, PRO98C, SER118C, SER233C, SER245C, SER24A, SER413A, SER418A, SER444A, SER447A, SER449A, SER476A, SER478A, SER90C, SER94C, THR121C, THR154C, THR214C, THR215C, THR237C, THR25A, THR274C, THR27A, THR31A, THR402A, THR409A, THR472A, THR5C, THR88C, THR97C, TRP103C, TRP175C, TRP225C, TRP242C, TRP252C, TRP446A, TYR217C, TYR30A, TYR32A, TYR347A, TYR371A, TYR399A, TYR3A, TYR404A, TYR407A, TYR454A, TYR465A, TYR477A, TYR479A, TYR76A, TYR87C, TYR99C, VAL116C, VAL11C, VAL155C, VAL160C, VAL224C, VAL236C, VAL246C, VAL265C, VAL267C, VAL279C, VAL410A, VAL419A, VAL432A, VAL457A
• A-D: ALA100A, ALA100D, ALA101A, ALA101D, ALA105A, ALA105D, ALA147A, ALA147D, ALA152A, ALA152D, ALA171A, ALA171D, ALA229A, ALA229D, ALA252A, ALA257A, ALA257D, ALA286A, ALA286D, ALA48A, ALA48D, ALA50A, ALA50D, ALA552A, ALA552D, ALA560A, ALA560D, ALA568A, ALA568D, ALA63A, ALA63D, ALA68A, ALA68D, ALA91A, ALA91D, ARG111A, ARG111D, ARG186A, ARG186D, ARG187A, ARG187D, ARG230A, ARG230D, ARG239A, ARG239D, ARG285A, ARG285D, ARG287A, ARG287D, ARG42A, ARG42D, ARG535A, ARG535D, ARG554A, ARG554D, ARG563A, ARG563D, ARG573A, ARG573D, ARG57A, ARG57D, ARG75A, ARG75D, ASN139A, ASN139D, ASN145A, ASN145D, ASN167A, ASN167D, ASN251A, ASN251D, ASN279A, ASN279D, ASN290A, ASN290D, ASN553A, ASN553D, ASN59A, ASN59D, ASN65A, ASN65D, ASN90A, ASN90D, ASN98A, ASN98D, ASN99A, ASN99D, ASP107A, ASP107D, ASP108A, ASP108D, ASP168A, ASP168D, ASP185A, ASP185D, ASP191A, ASP191D, ASP233A, ASP233D, ASP534A, ASP534D, ASP536A, ASP536D, ASP564A, ASP564D, ASP67A, ASP67D, ASP92A, ASP92D, ASP93A, ASP93D, CYS256D, GLN103A, GLN103D, GLN104A, GLN104D, GLN155A, GLN155D, GLN231A, GLN231D, GLN244A, GLN244D, GLN331A, GLN331D, GLN346A, GLN346D, GLN37A, GLN37D, GLN72A, GLN72D, GLN74A, GLN74D, GLU142A, GLU142D, GLU156A, GLU156D, GLU160A, GLU160D, GLU195A, GLU195D, GLU259A, GLU259D, GLU291A, GLU291D, GLU412A, GLU412D, GLU45A, GLU45D, GLU49A, GLU49D, GLU555A, GLU555D, GLU562A, GLU562D, GLU574A, GLU574D, GLY150A, GLY150D, GLY151A, GLY151D, GLY234A, GLY234D, GLY235A, GLY235D, GLY242A, GLY242D, GLY258A, GLY258D, GLY335A, GLY335D, GLY340A, GLY340D, GLY341A, GLY341D, GLY343A, GLY343D, GLY34A, GLY34D, GLY39A, GLY39D, GLY416A, GLY416D, GLY551A, GLY551D, GLY561A, GLY561D, GLY569A, GLY569D, GLY572A, GLY572D, GLY576D, GLY69A, GLY69D, GLY73A, GLY73D, HIS146A, HIS146D, HIS157A, HIS157D, HIS289A, HIS289D, HIS570A, HIS570D, HIS95A, HIS95D, ILE154A, ILE154D, ILE173A, ILE189A, ILE189D, ILE35A, ILE35D, ILE47A, ILE47D, ILE53A, ILE53D, ILE566A, ILE566D, ILE567A, ILE567D, ILE97A, ILE97D, LEU144A, LEU144D, LEU148A, LEU148D, LEU165A, LEU165D, LEU190A, LEU190D, LEU332A, LEU332D, LEU537A, LEU537D, LEU550A, LEU550D, LEU565A, LEU565D, LEU77A, LEU77D, LEU94A, LEU94D, LYS110A, LYS110D, LYS162A, LYS162D, LYS172A, LYS172D, LYS17A, LYS17D, LYS194A, LYS194D, LYS270A, LYS270D, LYS284A, LYS284D, LYS43A, LYS43D, LYS52A, LYS52D, LYS558A, LYS558D, LYS578A, LYS578D, MET102A, MET102D, MET109A, MET141A, MET141D, MET158A, MET158D, MET164A, MET164D, MET224A, MET224D, MET237A, MET237D, MET243A, MET243D, MET247A, MET247D, MET281A, MET281D, MET327A, MET327D, MET338A, MET338D, MET41A, MET70A, MET70D, MET78A, MET78D, PHE188A, PHE188D, PHE18A, PHE18D, PHE238A, PHE238D, PHE334A, PHE334D, PHE344A, PHE344D, PHE415A, PHE415D, PHE463A, PHE463D, PHE46A, PHE46D, PHE539A, PHE539D, PRO149A, PRO149D, PRO163A, PRO163D, PRO225A, PRO225D, PRO282A, PRO282D, PRO292A, PRO292D, PRO538A, PRO538D, PRO575A, PRO575D, PRO62A, PRO62D, PRO66A, PRO66D, PRO71A, PRO71D, PRO79A, PRO79D, SER138A, SER138D, SER169A, SER169D, SER260A, SER260D, SER288A, SER288D, SER339A, SER339D, SER349A, SER349D, SER413A, SER413D, SER51A, SER51D, SER533D, SER56A, SER56D, SER60A, SER60D, THR161A, THR161D, THR226A, THR226D, THR232A, THR232D, THR236A, THR236D, THR248A, THR248D, THR262A, THR262D, THR336A, THR336D, THR345A, THR345D, THR557A, THR557D, THR61A, THR61D, TRP106A, TRP106D, TRP223A, TRP223D, TRP240A, TRP240D, TRP96A, TRP96D, TYR140A, TYR140D, TYR170A, TYR170D, TYR267A, TYR267D, TYR280A, TYR280D, TYR30A, TYR30D, TYR337A, TYR337D, TYR347A, TYR347D, TYR556A, TYR556D, TYR571A, TYR571D, TYR64A, TYR64D, TYR76A, TYR76D, TYR80A, TYR80D, VAL143A, VAL143D, VAL153A, VAL153D, VAL159A, VAL159D, VAL166A, VAL166D, VAL227A, VAL227D, VAL228A, VAL228D, VAL241A, VAL241D, VAL283A, VAL283D, VAL328A, VAL328D, VAL342A, VAL342D, VAL54A, VAL54D, VAL559A, VAL559D, VAL58A, VAL58D
• A-E: ALA120A, ALA126A, ALA132E, ALA136E, ALA148E, ALA153E, ALA213A, ALA257A, ALA266A, ALA269A, ALA272A, ALA273A, ALA319E, ALA439A, ALA442A, ALA445A, ALA498A, ALA521A, ALA58E, ALA60E, ARG127A, ARG239A, ARG285A, ARG406E, ARG490A, ARG62E, ARG67E, ARG71E, ASN162E, ASN180E, ASN193E, ASN279A, ASN385A, ASN493A, ASN496A, ASN518A, ASN70E, ASP118A, ASP119A, ASP139E, ASP147E, ASP164E, ASP167E, ASP175E, ASP208A, ASP212A, ASP302A, ASP387A, ASP396E, ASP398E, ASP482A, ASP520A, CYS256A, CYS474A, GLN155A, GLN161E, GLN206A, GLN209A, GLN244A, GLN276A, GLN321E, GLN440A, GLN480A, GLU125A, GLU205A, GLU259A, GLU264A, GLU291A, GLU390A, GLU483A, GLU488A, GLY116A, GLY122A, GLY131E, GLY154E, GLY157E, GLY242A, GLY246A, GLY258A, GLY263A, GLY293A, GLY294A, GLY298A, GLY320E, GLY364E, GLY365E, GLY366E, GLY367E, GLY369E, GLY381A, GLY437A, GLY475A, GLY484A, GLY491A, GLY57E, GLY61E, GLY63E, GLY68E, HIS121A, HIS135E, HIS152E, HIS289A, HIS360E, HIS375E, HIS515A, HIS519A, ILE138E, ILE154A, ILE176E, ILE214A, ILE250A, ILE299A, ILE362E, ILE376E, ILE388A, ILE393A, ILE59E, ILE66E, LEU115A, LEU123A, LEU124A, LEU133E, LEU210A, LEU277A, LEU297A, LEU384A, LEU389A, LEU438A, LEU443A, LEU524A, LEU527A, LYS179E, LYS270A, LYS284A, LYS380A, LYS529A, LYS53E, MET130E, MET145E, MET158E, MET178E, MET243A, MET247A, MET249A, MET281A, MET295A, MET386A, MET393E, MET400E, MET485A, MET489A, MET64E, MET89E, PHE238A, PHE265A, PHE357E, PHE358E, PHE371E, PHE402E, PHE487A, PRO149E, PRO160E, PRO163E, PRO165E, PRO191E, PRO282A, PRO292A, PRO296A, PRO322E, PRO324E, PRO368E, PRO441A, PRO486A, PRO495A, PRO526A, SER144E, SER260A, SER278A, SER356E, SER359E, SER361E, SER403E, SER444A, SER476A, SER478A, SER481A, SER525A, THR127E, THR134E, THR248A, THR262A, THR399E, THR407E, THR436A, THR56E, TRP146E, TRP156E, TRP219A, TRP240A, TRP522A, TRP528A, TYR150E, TYR159E, TYR200A, TYR267A, TYR268A, TYR280A, TYR329A, TYR363E, TYR372E, TYR401E, TYR477A, TYR479A, TYR494A, TYR497A, VAL114A, VAL143E, VAL151E, VAL153A, VAL155E, VAL241A, VAL245A, VAL261A, VAL274A, VAL275A, VAL283A, VAL370E, VAL377E, VAL432A, VAL492A, VAL511A, VAL523A, VAL65E, VAL69E
• A-F: ALA126A, ALA152A, ALA171F, ALA194F, ALA252A, ALA257A, ALA41F, ARG120F, ARG127A, ARG151F, ARG153F, ARG81F, ARG83F, ASN251A, ASP113F, ASP170F, ASP189F, ASP80F, CYS256A, GLN155A, GLN86F, GLU124F, GLU125A, GLU131A, GLU156A, GLU259A, GLY115F, GLY129A, GLY152F, GLY157F, GLY193F, GLY258A, GLY263A, HIS156F, HIS157A, HIS42F, HIS53F, ILE122F, ILE154A, ILE191F, ILE250A, ILE52F, ILE82F, LEU117F, LEU124A, LEU128A, LEU172F, LEU255A, LYS130A, LYS254A, LYS50F, MET158A, MET190F, MET247A, PHE169F, SER260A, SER51F, THR154F, THR262A, TYR253A, TYR84F, VAL153A, VAL155F, VAL160F, VAL261A, VAL85F
• A-G: ALA19G, ALA36G, ALA48G, ALA50G, ALA552G, ALA568A, ALA577A, ARG42G, ARG44G, ARG554G, ARG573A, ARG573G, ARG57A, ASN553G, ASN59A, ASN90G, ASP16G, ASP55A, ASP93G, GLU45G, GLU49G, GLU555G, GLU574A, GLU574G, GLY569A, GLY572G, GLY576A, HIS570G, ILE53A, ILE53G, LEU550G, LEU579A, LYS38G, LYS52A, LYS52G, LYS578A, LYS578G, MET41G, MET88G, PHE18G, PHE46G, PRO575A, PRO79G, SER15G, SER51A, SER56A, SER60A, THR557G, THR61A, TYR556G, TYR76G, VAL54A, VAL58A
• B-C: ALA102C, ALA105C, ALA125C, ALA12C, ALA203B, ALA207B, ALA238C, ALA253C, ALA266B, ALA292B, ALA308B, ALA315B, ALA319B, ALA330B, ALA391B, ALA392B, ALA397B, ALA65C, ALA6C, ALA76C, ALA77C, ARG101C, ARG108C, ARG120C, ARG126C, ARG15C, ARG16C, ARG200B, ARG202B, ARG230B, ARG244C, ARG318B, ARG336B, ARG67C, ARG81C, ARG83C, ASN107C, ASN223B, ASN254B, ASN299B, ASN313B, ASN326B, ASN8C, ASP10B, ASP113C, ASP129C, ASP20C, ASP230C, ASP235C, ASP253B, ASP257B, ASP262B, ASP264C, ASP291B, ASP293B, ASP294B, ASP344B, ASP396B, ASP398B, ASP63C, ASP80C, ASP9B, CYS311B, CYS314B, CYS331B, CYS332B, CYS394B, CYS64C, GLN100C, GLN13C, GLN205B, GLN226C, GLN239C, GLN250C, GLN256B, GLN296B, GLN321B, GLN329B, GLN349B, GLN3C, GLN68C, GLU104C, GLU124C, GLU229B, GLU232C, GLU269B, GLU335B, GLU337B, GLU61C, GLU74C, GLY111C, GLY115C, GLY12B, GLY226B, GLY231B, GLY247C, GLY248C, GLY255B, GLY258B, GLY261B, GLY266C, GLY286B, GLY309B, GLY320B, GLY325B, GLY339B, GLY342B, GLY346B, GLY350B, GLY75C, GLY79C, GLY7C, HIS228B, HIS232B, HIS241C, HIS360B, HIS53C, ILE122C, ILE123C, ILE130C, ILE133C, ILE240C, ILE251B, ILE264B, ILE327B, ILE334B, ILE362B, ILE395B, ILE52C, ILE69C, ILE82C, LEU106C, LEU117C, LEU234B, LEU247B, LEU250B, LEU260B, LEU280B, LEU297B, LEU307B, LEU333B, LEU340B, LEU56C, LYS110C, LYS11B, LYS201B, LYS243C, LYS252B, LYS254C, LYS256C, LYS262C, LYS263C, LYS268C, LYS272B, LYS278B, LYS281B, LYS282B, LYS382B, LYS71C, MET19C, MET204B, MET225B, MET234C, MET255C, MET283B, MET295B, MET317B, MET328B, MET347B, MET393B, MET400B, MET59C, PHE249C, PHE287B, PHE345B, PHE357B, PHE4C, PRO114C, PRO21C, PRO227B, PRO231C, PRO251C, PRO284B, PRO2C, PRO322B, PRO324B, PRO341B, PRO343B, PRO54C, PRO62C, PRO72C, PRO98C, SER233C, SER245C, SER249B, SER259B, SER279B, SER285B, SER316B, SER356B, SER359B, SER361B, SER9C, THR121C, THR237C, THR288B, THR338B, THR399B, THR5C, THR73C, TRP103C, TRP242C, TRP252C, TRP298B, TYR109C, TYR217C, TYR248B, TYR265B, TYR290B, TYR363B, TYR84C, TYR99C, VAL112C, VAL116C, VAL199B, VAL236C, VAL246C, VAL263B, VAL265C, VAL267C, VAL268B, VAL289B, VAL310B, VAL312B, VAL323B, VAL353B, VAL66C, VAL70C
• B-D: ALA120D, ALA126D, ALA132B, ALA136B, ALA148B, ALA153B, ALA213D, ALA257D, ALA266D, ALA269D, ALA272D, ALA273D, ALA319B, ALA439D, ALA442D, ALA445D, ALA498D, ALA521D, ALA58B, ALA60B, ARG127D, ARG239D, ARG285D, ARG406B, ARG490D, ARG62B, ARG67B, ARG71B, ASN162B, ASN193B, ASN279D, ASN385D, ASN493D, ASN496D, ASN518D, ASN70B, ASP118D, ASP119D, ASP139B, ASP147B, ASP164B, ASP167B, ASP175B, ASP208D, ASP212D, ASP302D, ASP387D, ASP396B, ASP398B, ASP482D, ASP520D, CYS256D, CYS474D, GLN155D, GLN161B, GLN206D, GLN209D, GLN244D, GLN276D, GLN321B, GLN440D, GLN480D, GLN504D, GLU125D, GLU205D, GLU259D, GLU264D, GLU291D, GLU390D, GLU483D, GLU488D, GLY116D, GLY122D, GLY131B, GLY154B, GLY157B, GLY166B, GLY242D, GLY246D, GLY258D, GLY263D, GLY293D, GLY294D, GLY298D, GLY320B, GLY364B, GLY365B, GLY366B, GLY367B, GLY369B, GLY381D, GLY437D, GLY475D, GLY484D, GLY491D, GLY57B, GLY61B, GLY63B, GLY68B, HIS121D, HIS135B, HIS152B, HIS289D, HIS360B, HIS375B, HIS515D, HIS519D, ILE138B, ILE154D, ILE176B, ILE214D, ILE250D, ILE299D, ILE362B, ILE376B, ILE388D, ILE393D, ILE59B, ILE66B, LEU115D, LEU123D, LEU124D, LEU133B, LEU210D, LEU277D, LEU297D, LEU384D, LEU389D, LEU438D, LEU443D, LEU524D, LEU527D, LYS179B, LYS270D, LYS284D, LYS380D, LYS529D, LYS53B, MET130B, MET145B, MET158B, MET178B, MET243D, MET247D, MET249D, MET281D, MET295D, MET386D, MET393B, MET400B, MET485D, MET489D, MET64B, MET89B, PHE238D, PHE265D, PHE357B, PHE358B, PHE371B, PHE402B, PHE487D, PHE54B, PRO149B, PRO160B, PRO163B, PRO165B, PRO191B, PRO282D, PRO292D, PRO296D, PRO322B, PRO368B, PRO441D, PRO486D, PRO495D, PRO526D, SER144B, SER260D, SER278D, SER356B, SER359B, SER361B, SER403B, SER444D, SER476D, SER478D, SER481D, SER525D, THR127B, THR134B, THR248D, THR262D, THR399B, THR407B, THR436D, THR56B, TRP146B, TRP156B, TRP219D, TRP240D, TRP522D, TRP528D, TYR150B, TYR159B, TYR200D, TYR267D, TYR268D, TYR280D, TYR329D, TYR363B, TYR372B, TYR401B, TYR477D, TYR479D, TYR494D, TYR497D, VAL114D, VAL143B, VAL151B, VAL153D, VAL155B, VAL241D, VAL245D, VAL261D, VAL274D, VAL275D, VAL283D, VAL370B, VAL432D, VAL492D, VAL511D, VAL523D, VAL65B, VAL69B
• B-E: ALA116B, ALA116E, ALA128B, ALA128E, ALA132B, ALA132E, ALA136B, ALA136E, ALA216B, ALA216E, ALA217B, ALA217E, ALA85B, ALA85E, ARG117B, ARG117E, ARG188B, ARG188E, ARG379B, ARG379E, ARG91B, ARG91E, ASN162E, ASN180B, ASN180E, ASN223B, ASN223E, ASN29B, ASN29E, ASN37B, ASN37E, ASP121B, ASP121E, ASP139B, ASP139E, ASP164B, ASP164E, ASP175B, ASP175E, ASP88B, ASP88E, CYS224B, CYS224E, GLN161B, GLN218B, GLN218E, GLN22B, GLN22E, GLU181B, GLU181E, GLU215B, GLU215E, GLU220B, GLU220E, GLU229B, GLU229E, GLU93B, GLU93E, GLY125B, GLY125E, GLY131B, GLY131E, GLY182B, GLY182E, GLY184B, GLY184E, GLY222B, GLY222E, GLY226B, GLY226E, HIS135B, HIS135E, HIS152B, HIS152E, HIS228B, HIS228E, ILE118B, ILE118E, ILE138B, ILE138E, ILE176B, ILE176E, ILE190E, ILE212B, ILE212E, ILE32B, ILE32E, ILE40B, ILE40E, LEU119B, LEU119E, LEU126B, LEU126E, LEU133B, LEU133E, LEU187B, LEU187E, LEU213B, LEU213E, LEU27B, LEU27E, LEU90B, LEU90E, LYS179B, LYS179E, LYS28B, LYS28E, LYS33B, LYS33E, LYS34B, MET130B, MET130E, MET178B, MET178E, MET221B, MET221E, MET225B, MET225E, MET89B, MET89E, PHE185B, PHE185E, PHE219B, PHE219E, PRO113B, PRO113E, PRO114B, PRO114E, PRO160B, PRO160E, PRO163B, PRO163E, PRO165B, PRO165E, PRO177B, PRO177E, PRO183B, PRO183E, PRO227B, PRO227E, PRO26B, PRO26E, SER120B, SER120E, SER123B, SER123E, SER129B, SER129E, SER25B, SER25E, SER94B, SER94E, THR115B, THR115E, THR127B, THR127E, THR134B, THR134E, THR186B, THR186E, THR39B, THR39E, TRP156B, TRP156E, TYR122B, TYR122E, TYR159B, TYR159E, VAL124B, VAL124E, VAL174B, VAL174E, VAL36B, VAL36E, VAL86B, VAL86E, VAL92B, VAL92E
• B-F: ALA148B, ALA253F, ARG71B, ASN142B, ASP139B, ASP147B, ASP257F, GLN250F, GLY247F, GLY248F, GLY260F, GLY261F, HIS135B, HIS241F, ILE138B, ILE258F, LYS259F, LYS262F, MET145B, MET255F, PHE249F, PRO149B, SER144B, SER245F, THR134B, TRP146B, TRP242F, TRP252F, VAL143B, VAL151B, VAL246F
• C-D: ALA126D, ALA152D, ALA171C, ALA194C, ALA252D, ALA257D, ALA41C, ARG120C, ARG127D, ARG151C, ARG153C, ARG174C, ARG81C, ARG83C, ASN251D, ASP113C, ASP170C, ASP189C, ASP80C, CYS256D, GLN155D, GLN86C, GLU124C, GLU125D, GLU127C, GLU131D, GLU156D, GLU259D, GLY115C, GLY129D, GLY152C, GLY157C, GLY193C, GLY258D, GLY263D, HIS156C, HIS157D, HIS42C, HIS53C, ILE122C, ILE123C, ILE154D, ILE191C, ILE250D, ILE52C, ILE82C, LEU117C, LEU124D, LEU128D, LEU172C, LEU255D, LYS130D, LYS254D, LYS50C, MET158D, MET190C, MET247D, PHE169C, SER260D, SER51C, THR121C, THR154C, THR262D, TYR253D, TYR84C, VAL153D, VAL155C, VAL160C, VAL261D, VAL85C
• C-E: ALA148E, ALA253C, ARG71E, ASN142E, ASP139E, ASP147E, ASP257C, GLN250C, GLY247C, GLY248C, GLY260C, GLY261C, HIS135E, HIS241C, ILE138E, ILE258C, LYS259C, LYS262C, MET145E, MET255C, PHE249C, PRO149E, PRO251C, SER144E, SER245C, TRP146E, TRP242C, TRP252C, VAL143E, VAL151E, VAL246C
• D-E: ALA217E, ALA286D, ALA348E, ALA351E, ALA381E, ALA473D, ALA498D, ARG188E, ARG285D, ARG336E, ARG379E, ARG456D, ASN180E, ASN189E, ASN223E, ASN374E, ASN493D, ASN496D, ASN500D, ASP164E, ASP344E, ASP466D, ASP469D, ASP482D, CYS224E, CYS331E, CYS332E, CYS471D, CYS474D, GLN218E, GLN329E, GLN349E, GLN468D, GLN470D, GLN480D, GLU181E, GLU220E, GLU335E, GLU455D, GLU483D, GLY182E, GLY184E, GLY222E, GLY226E, GLY325E, GLY335D, GLY340D, GLY341D, GLY343D, GLY346E, GLY350E, GLY364E, GLY365E, GLY452D, GLY461D, GLY475D, GLY484D, HIS228E, HIS232E, HIS360E, HIS375E, HIS380E, HIS503D, ILE176E, ILE362E, ILE376E, LEU451D, LEU460D, LEU467D, LYS179E, LYS284D, LYS382E, MET178E, MET221E, MET225E, MET281D, MET328E, MET338D, MET347E, PHE185E, PHE334D, PHE344D, PHE345E, PHE357E, PHE358E, PHE371E, PHE462D, PHE463D, PRO163E, PRO177E, PRO183E, PRO227E, PRO282D, PRO324E, PRO341E, PRO343E, PRO495D, SER339D, SER352E, SER354E, SER355E, SER356E, SER359E, SER361E, SER447D, SER476D, SER478D, SER481D, THR378E, THR472D, TYR280D, TYR347D, TYR363E, TYR372E, TYR454D, TYR465D, TYR479D, TYR494D, TYR497D, VAL283D, VAL342D, VAL353E, VAL370E, VAL377E, VAL492D, VAL501D
• D-F: ALA12F, ALA159F, ALA171F, ALA19D, ALA220F, ALA228F, ALA238F, ALA26D, ALA395D, ALA400D, ALA406D, ALA411D, ALA421D, ALA445D, ALA473D, ALA6F, ARG101F, ARG120F, ARG147F, ARG151F, ARG153F, ARG15F, ARG161F, ARG173F, ARG174F, ARG218F, ARG244F, ARG276F, ARG394D, ARG420D, ARG456D, ARG459D, ARG75D, ASN219F, ASN269F, ASN385D, ASN397D, ASN4D, ASN9D, ASP113F, ASP163F, ASP165F, ASP170F, ASP230F, ASP235F, ASP264F, ASP370D, ASP382D, ASP387D, ASP398D, ASP466D, ASP469D, ASP89F, CYS471D, CYS474D, GLN100F, GLN221F, GLN226F, GLN239F, GLN250F, GLN346D, GLN403D, GLN468D, GLN470D, GLN480D, GLN72D, GLN74D, GLN86F, GLU124F, GLU20D, GLU227F, GLU232F, GLU23D, GLU280F, GLU28D, GLU366D, GLU390D, GLU391D, GLU396D, GLU405D, GLU412D, GLU455D, GLU483D, GLY115F, GLY119F, GLY157F, GLY166F, GLY223F, GLY247F, GLY248F, GLY260F, GLY261F, GLY266F, GLY277F, GLY278F, GLY368D, GLY373D, GLY381D, GLY416D, GLY417D, GLY452D, GLY458D, GLY461D, GLY475D, GLY69D, GLY73D, GLY7F, HIS156F, HIS158F, HIS241F, HIS414D, HIS453D, ILE122F, ILE123F, ILE240F, ILE258F, ILE367D, ILE388D, ILE392D, ILE393D, ILE96F, LEU117F, LEU11D, LEU162F, LEU172F, LEU270F, LEU272F, LEU384D, LEU389D, LEU401D, LEU443D, LEU448D, LEU451D, LEU460D, LEU467D, LEU77D, LYS164F, LYS17D, LYS21D, LYS243F, LYS259F, LYS262F, LYS263F, LYS268F, LYS271F, LYS363D, LYS380D, LYS383D, MET14D, MET167F, MET168F, MET216F, MET234F, MET255F, MET386D, MET450D, MET70D, MET78D, MET91F, PHE10D, PHE169F, PHE18D, PHE249F, PHE273F, PHE29D, PHE415D, PHE462D, PHE463D, PHE92F, PHE93F, PRO114F, PRO22D, PRO231F, PRO251F, PRO275F, PRO2D, PRO408D, PRO441D, PRO71D, PRO98F, SER118F, SER233F, SER245F, SER24D, SER413D, SER418D, SER444D, SER447D, SER449D, SER476D, SER478D, SER90F, SER94F, THR121F, THR154F, THR214F, THR215F, THR237F, THR25D, THR274F, THR27D, THR31D, THR402D, THR409D, THR472D, THR5F, THR88F, THR97F, TRP103F, TRP175F, TRP225F, TRP242F, TRP252F, TRP446D, TYR217F, TYR30D, TYR32D, TYR347D, TYR371D, TYR399D, TYR3D, TYR404D, TYR407D, TYR454D, TYR465D, TYR477D, TYR479D, TYR76D, TYR87F, TYR99F, VAL116F, VAL11F, VAL155F, VAL160F, VAL224F, VAL236F, VAL246F, VAL265F, VAL267F, VAL279F, VAL410D, VAL419D, VAL432D, VAL457D
• D-G: ALA13D, ALA13G, ALA197D, ALA197G, ALA198D, ALA198G, ALA19D, ALA19G, ALA308D, ALA308G, ARG186D, ARG186G, ARG187D, ARG187G, ARG305D, ARG305G, ARG316D, ARG316G, ARG535D, ARG535G, ARG541D, ARG541G, ARG546D, ARG546G, ARG554D, ARG554G, ASN193D, ASN193G, ASN312D, ASN312G, ASN355D, ASN355G, ASN4D, ASN4G, ASN553D, ASN553G, ASN83G, ASN9D, ASN9G, ASP16D, ASP16G, ASP178D, ASP178G, ASP179D, ASP182D, ASP182G, ASP191D, ASP191G, ASP201D, ASP201G, ASP313D, ASP313G, ASP536D, ASP536G, ASP540D, ASP540G, ASP5D, ASP5G, ASP86D, ASP86G, GLN206D, GLN206G, GLN7D, GLN7G, GLU195D, GLU195G, GLU20D, GLU20G, GLU23D, GLU23G, GLU547D, GLU547G, GLU555D, GLU555G, GLY199D, GLY199G, GLY204D, GLY204G, GLY542D, GLY542G, HIS84D, HIS84G, HIS8D, HIS8G, ILE192D, ILE192G, ILE6D, ILE6G, ILE87D, ILE87G, LEU11D, LEU11G, LEU309D, LEU309G, LEU550D, LEU550G, LYS12D, LYS12G, LYS17D, LYS17G, LYS194D, LYS194G, LYS202D, LYS202G, LYS211D, LYS211G, LYS21D, LYS21G, LYS38D, LYS38G, LYS558D, LYS558G, MET14D, MET14G, MET81D, MET81G, MET88D, MET88G, PHE10D, PHE18D, PHE18G, PHE196D, PHE196G, PHE310D, PHE310G, PRO203D, PRO203G, PRO22D, PRO22G, PRO2D, PRO2G, PRO307D, PRO307G, PRO311D, PRO311G, PRO79D, PRO79G, SER15D, SER15G, SER24G, SER306D, SER306G, SER533D, SER533G, THR409D, THR409G, THR557D, THR557G, THR85D, THR85G, TYR200D, TYR200G, TYR32D, TYR32G, TYR3D, TYR3G, TYR407D, TYR407G, TYR543D, TYR543G, TYR556D, TYR556G, TYR76D, TYR76G
• D-I: ARG161I, ASP201D, GLU280I, GLY204D, LYS194D, LYS202D, PRO203D, VAL279I
• E-F: ALA102F, ALA105F, ALA125F, ALA12F, ALA203E, ALA207E, ALA238F, ALA253F, ALA266E, ALA292E, ALA308E, ALA315E, ALA319E, ALA330E, ALA391E, ALA392E, ALA397E, ALA65F, ALA6F, ALA76F, ALA77F, ARG101F, ARG108F, ARG120F, ARG126F, ARG15F, ARG16F, ARG200E, ARG202E, ARG230E, ARG244F, ARG318E, ARG336E, ARG67F, ARG81F, ARG83F, ASN107F, ASN223E, ASN254E, ASN299E, ASN313E, ASN326E, ASN8F, ASP10E, ASP113F, ASP129F, ASP20F, ASP230F, ASP235F, ASP253E, ASP257E, ASP262E, ASP264F, ASP291E, ASP293E, ASP294E, ASP344E, ASP396E, ASP398E, ASP63F, ASP80F, ASP9E, CYS311E, CYS314E, CYS331E, CYS332E, CYS394E, CYS64F, GLN100F, GLN13F, GLN205E, GLN226F, GLN239F, GLN250F, GLN256E, GLN296E, GLN321E, GLN329E, GLN349E, GLN3F, GLN68F, GLU104F, GLU124F, GLU127F, GLU229E, GLU232F, GLU269E, GLU335E, GLU337E, GLU61F, GLU74F, GLY111F, GLY115F, GLY12E, GLY226E, GLY231E, GLY247F, GLY248F, GLY255E, GLY258E, GLY261E, GLY266F, GLY286E, GLY309E, GLY320E, GLY325E, GLY339E, GLY342E, GLY346E, GLY350E, GLY75F, GLY79F, GLY7F, HIS228E, HIS232E, HIS241F, HIS360E, HIS53F, ILE122F, ILE123F, ILE130F, ILE133F, ILE240F, ILE251E, ILE264E, ILE327E, ILE334E, ILE362E, ILE395E, ILE52F, ILE69F, ILE82F, LEU106F, LEU117F, LEU234E, LEU247E, LEU250E, LEU260E, LEU280E, LEU297E, LEU307E, LEU333E, LEU340E, LEU56F, LYS110F, LYS11E, LYS201E, LYS243F, LYS252E, LYS254F, LYS256F, LYS262F, LYS263F, LYS268F, LYS272E, LYS278E, LYS281E, LYS282E, LYS382E, LYS71F, MET19F, MET204E, MET225E, MET234F, MET255F, MET283E, MET295E, MET317E, MET328E, MET347E, MET393E, MET400E, MET59F, PHE249F, PHE287E, PHE345E, PHE357E, PHE4F, PRO114F, PRO21F, PRO227E, PRO231F, PRO251F, PRO284E, PRO2F, PRO322E, PRO324E, PRO341E, PRO343E, PRO54F, PRO62F, PRO72F, PRO98F, SER233F, SER245F, SER249E, SER259E, SER279E, SER285E, SER316E, SER356E, SER359E, SER361E, SER9F, THR121F, THR237F, THR288E, THR338E, THR399E, THR5F, THR73F, TRP103F, TRP242F, TRP252F, TRP298E, TYR109F, TYR217F, TYR248E, TYR265E, TYR290E, TYR363E, TYR84F, TYR99F, VAL112F, VAL116F, VAL199E, VAL236F, VAL246F, VAL263E, VAL265F, VAL267F, VAL268E, VAL289E, VAL310E, VAL312E, VAL323E, VAL353E, VAL66F, VAL70F
• F-G: ARG161F, ASP201G, GLU280F, LYS194G, LYS202G, PRO203G, VAL279F
• G-H: ALA217H, ALA286G, ALA348H, ALA351H, ALA381H, ALA473G, ALA498G, ARG188H, ARG285G, ARG336H, ARG379H, ARG394G, ARG456G, ASN180H, ASN189H, ASN223H, ASN374H, ASN493G, ASN496G, ASN500G, ASP164H, ASP344H, ASP466G, ASP469G, ASP482G, CYS224H, CYS331H, CYS332H, CYS471G, CYS474G, GLN218H, GLN329H, GLN349H, GLN468G, GLN470G, GLN480G, GLU181H, GLU220H, GLU335H, GLU455G, GLU483G, GLY182H, GLY184H, GLY222H, GLY226H, GLY325H, GLY335G, GLY340G, GLY341G, GLY343G, GLY346H, GLY350H, GLY364H, GLY365H, GLY452G, GLY461G, GLY475G, GLY484G, HIS228H, HIS232H, HIS360H, HIS375H, HIS380H, HIS503G, ILE176H, ILE362H, ILE376H, LEU451G, LEU460G, LEU467G, LYS179H, LYS284G, LYS382H, MET178H, MET221H, MET225H, MET281G, MET283H, MET328H, MET338G, MET347H, PHE185H, PHE334G, PHE344G, PHE345H, PHE357H, PHE358H, PHE371H, PHE462G, PHE463G, PRO163H, PRO177H, PRO183H, PRO227H, PRO282G, PRO324H, PRO341H, PRO495G, SER339G, SER352H, SER354H, SER355H, SER356H, SER359H, SER361H, SER447G, SER476G, SER478G, SER481G, THR378H, THR472G, TYR347G, TYR363H, TYR372H, TYR454G, TYR465G, TYR479G, TYR494G, TYR497G, VAL283G, VAL342G, VAL353H, VAL370H, VAL377H, VAL492G, VAL501G
• G-I: ALA102I, ALA12I, ALA159I, ALA171I, ALA19G, ALA220I, ALA228I, ALA238I, ALA26G, ALA372G, ALA395G, ALA400G, ALA406G, ALA411G, ALA421G, ALA445G, ALA473G, ALA6I, ARG101I, ARG120I, ARG147I, ARG151I, ARG153I, ARG15I, ARG161I, ARG173I, ARG174I, ARG218I, ARG244I, ARG276I, ARG394G, ARG420G, ARG456G, ARG459G, ARG75G, ASN219I, ASN269I, ASN385G, ASN397G, ASN4G, ASN9G, ASP113I, ASP163I, ASP165I, ASP170I, ASP230I, ASP235I, ASP264I, ASP370G, ASP382G, ASP387G, ASP398G, ASP466G, ASP469G, ASP89I, CYS471G, CYS474G, GLN100I, GLN221I, GLN226I, GLN239I, GLN250I, GLN346G, GLN403G, GLN468G, GLN470G, GLN480G, GLN72G, GLN74G, GLN86I, GLU124I, GLU20G, GLU227I, GLU232I, GLU23G, GLU280I, GLU28G, GLU366G, GLU390G, GLU391G, GLU396G, GLU405G, GLU412G, GLU455G, GLU483G, GLY115I, GLY119I, GLY157I, GLY166I, GLY223I, GLY247I, GLY248I, GLY260I, GLY261I, GLY266I, GLY277I, GLY278I, GLY368G, GLY373G, GLY381G, GLY416G, GLY417G, GLY452G, GLY458G, GLY461G, GLY475G, GLY69G, GLY73G, GLY7I, HIS156I, HIS158I, HIS241I, HIS414G, HIS453G, ILE122I, ILE123I, ILE240I, ILE258I, ILE367G, ILE388G, ILE392G, ILE393G, ILE96I, LEU117I, LEU11G, LEU162I, LEU172I, LEU270I, LEU272I, LEU369G, LEU384G, LEU389G, LEU401G, LEU443G, LEU448G, LEU451G, LEU460G, LEU467G, LEU77G, LYS164I, LYS17G, LYS21G, LYS243I, LYS254I, LYS259I, LYS262I, LYS263I, LYS268I, LYS271I, LYS363G, LYS380G, LYS383G, MET14G, MET167I, MET168I, MET216I, MET234I, MET255I, MET386G, MET450G, MET70G, MET78G, MET91I, PHE10G, PHE169I, PHE18G, PHE249I, PHE273I, PHE29G, PHE415G, PHE462G, PHE463G, PHE92I, PHE93I, PRO114I, PRO22G, PRO231I, PRO251I, PRO275I, PRO2G, PRO408G, PRO441G, PRO71G, PRO98I, SER118I, SER233I, SER245I, SER24G, SER413G, SER418G, SER444G, SER447G, SER449G, SER476G, SER478G, SER90I, SER94I, THR121I, THR154I, THR214I, THR215I, THR237I, THR25G, THR274I, THR27G, THR31G, THR402G, THR409G, THR472G, THR5I, THR88I, THR97I, TRP103I, TRP175I, TRP225I, TRP242I, TRP252I, TRP446G, TYR217I, TYR30G, TYR32G, TYR347G, TYR371G, TYR399G, TYR3G, TYR404G, TYR407G, TYR454G, TYR465G, TYR477G, TYR479G, TYR76G, TYR87I, TYR99I, VAL116I, VAL11I, VAL155I, VAL160I, VAL224I, VAL236I, VAL246I, VAL265I, VAL267I, VAL279I, VAL410G, VAL419G, VAL432G, VAL457G
• H-I: ALA102I, ALA105I, ALA125I, ALA12I, ALA203H, ALA207H, ALA238I, ALA253I, ALA266H, ALA292H, ALA308H, ALA315H, ALA319H, ALA330H, ALA391H, ALA392H, ALA397H, ALA65I, ALA6I, ALA76I, ALA77I, ARG101I, ARG108I, ARG120I, ARG126I, ARG15I, ARG16I, ARG200H, ARG202H, ARG230H, ARG244I, ARG318H, ARG336H, ARG426H, ARG67I, ARG81I, ARG83I, ASN107I, ASN223H, ASN254H, ASN299H, ASN313H, ASN326H, ASN8I, ASP10H, ASP113I, ASP129I, ASP20I, ASP230I, ASP235I, ASP253H, ASP257H, ASP262H, ASP264I, ASP291H, ASP293H, ASP294H, ASP344H, ASP396H, ASP398H, ASP63I, ASP80I, ASP9H, CYS224H, CYS311H, CYS314H, CYS331H, CYS332H, CYS394H, CYS64I, GLN100I, GLN13I, GLN205H, GLN226I, GLN239I, GLN250I, GLN256H, GLN296H, GLN321H, GLN329H, GLN349H, GLN3I, GLN68I, GLU104I, GLU124I, GLU127I, GLU229H, GLU232I, GLU269H, GLU335H, GLU337H, GLU61I, GLU74I, GLY111I, GLY115I, GLY12H, GLY226H, GLY231H, GLY247I, GLY248I, GLY255H, GLY258H, GLY261H, GLY266I, GLY286H, GLY309H, GLY320H, GLY325H, GLY339H, GLY342H, GLY346H, GLY350H, GLY75I, GLY79I, GLY7I, HIS228H, HIS232H, HIS241I, HIS360H, HIS53I, ILE122I, ILE123I, ILE130I, ILE133I, ILE240I, ILE251H, ILE264H, ILE327H, ILE334H, ILE362H, ILE395H, ILE52I, ILE69I, ILE82I, LEU106I, LEU117I, LEU247H, LEU250H, LEU260H, LEU280H, LEU297H, LEU307H, LEU333H, LEU340H, LEU56I, LYS110I, LYS11H, LYS201H, LYS243I, LYS252H, LYS254I, LYS256I, LYS263I, LYS272H, LYS278H, LYS281H, LYS282H, LYS382H, LYS71I, MET19I, MET204H, MET225H, MET234I, MET255I, MET283H, MET295H, MET317H, MET328H, MET347H, MET393H, MET400H, MET425H, MET59I, PHE249I, PHE287H, PHE345H, PHE357H, PHE4I, PRO114I, PRO21I, PRO227H, PRO231I, PRO251I, PRO284H, PRO2I, PRO322H, PRO324H, PRO341H, PRO343H, PRO54I, PRO62I, PRO72I, PRO98I, SER233I, SER245I, SER249H, SER259H, SER279H, SER285H, SER316H, SER356H, SER359H, SER361H, SER9I, THR121I, THR237I, THR288H, THR338H, THR399H, THR5I, THR73I, TRP103I, TRP242I, TRP252I, TRP298H, TYR109I, TYR217I, TYR248H, TYR265H, TYR290H, TYR363H, TYR84I, TYR99I, VAL112I, VAL116I, VAL199H, VAL236I, VAL246I, VAL263H, VAL265I, VAL267I, VAL268H, VAL289H, VAL310H, VAL312H, VAL323H, VAL353H, VAL66I, VAL70I