3SN6

crystal structure of the beta2 adrenergic receptor-gs protein complex

• Total interactions analyzed: 10
• Total true interactions: 7
• Strongest Interaction:
  • Chains: B-G
  • Int. Res.: 178
  • Norm. En. per Res.: -3.9564
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-86.9806	-152.3911	-411.475	-650.8467	168	24	4	17210	12	74	58
A-R	-28.2461	-28.4237	-296.914	-353.5838	125	10	8	13662	2	44	55
A-N	-4.3008	3.9465	-192.47	-192.8243	89	22	0	8511	1	31	27
B-G	-65.25	-68.2069	-570.778	-704.2348	178	30	34	24917	4	48	49
B-R	0.0	21.8184	-5.6326	16.1857	15	0	0	380	0	10	11
B-N	-15.2623	-9.0094	-128.815	-153.0867	74	9	3	5298	0	13	11
G-N	0.0	0.0	-0.0275	-0.0275	11	0	0	26	0	0	0

Interface residues

• A-B: ALA109A, ALA18A, ALA203B, ALA206B, ALA22A, ALA56B, ALA92B, ARG129B, ARG134B, ARG165A, ARG201A, ARG20A, ARG228A, ARG231A, ARG232A, ARG280A, ARG314B, ARG38A, ARG42A, ARG52B, ARG68B, ARG96B, ASN119B, ASN132B, ASN167A, ASN230B, ASN239A, ASN23A, ASN279A, ASN313B, ASN88B, ASP118B, ASP163B, ASP173A, ASP186B, ASP205B, ASP223A, ASP228B, ASP240A, ASP246B, ASP290B, ASP291B, ASP33A, ASP76B, ASP83B, CYS174A, CYS204B, CYS237A, CYS271B, GLN170A, GLN19A, GLN227A, GLN236A, GLN29A, GLN31A, GLN35A, GLN75B, GLU130B, GLU15A, GLU168A, GLU16A, GLU209A, GLU21A, GLU230A, GLU27A, GLY116B, GLY131B, GLY144B, GLY162B, GLY185B, GLY206A, GLY225A, GLY226A, GLY272B, GLY53B, GLY77B, HIS142B, HIS183B, HIS220A, HIS41A, HIS54B, HIS91B, ILE120B, ILE172A, ILE207A, ILE229B, ILE235A, ILE26A, ILE270B, ILE273B, ILE285A, ILE80B, ILE81B, ILE93B, LEU113A, LEU117B, LEU146B, LEU171A, LEU282A, LEU30A, LEU43A, LEU44A, LEU55B, LEU69B, LEU79B, LEU95B, LYS17A, LYS211A, LYS233A, LYS24A, LYS25A, LYS32A, LYS34A, LYS57B, LYS78B, LYS89B, MET101B, MET188B, MET221A, PHE208A, PHE219A, PHE222A, PHE238A, PHE292B, PRO94B, SER147B, SER161B, SER166A, SER205A, SER227B, SER245B, SER74B, SER84B, SER97B, SER98B, THR128B, THR143B, THR164B, THR165B, THR184B, THR210A, THR242A, THR274B, THR40A, THR86B, THR87B, TRP234A, TRP281A, TRP332B, TRP82B, TRP99B, TYR145B, TYR169A, TYR289B, TYR37A, TYR59B, TYR85B, VAL100B, VAL114A, VAL133B, VAL135B, VAL187B, VAL202A, VAL224A, VAL241A, VAL315B, VAL36A, VAL90B
• A-R: ALA134R, ALA226R, ALA271R, ALA324A, ALA351A, ALA39A, ARG131R, ARG221R, ARG228R, ARG239R, ARG328R, ARG342A, ARG347A, ARG356A, ARG373A, ARG380A, ARG385A, ARG389A, ARG38A, ASN148R, ASN218A, ASN377A, ASN69R, ASP130R, ASP139A, ASP215A, ASP234R, ASP323A, ASP343A, ASP378A, ASP381A, CYS359A, CYS379A, GLN142R, GLN224R, GLN229R, GLN231R, GLN31A, GLN35A, GLN384A, GLN390A, GLU225R, GLU237R, GLU268R, GLU344A, GLU392A, GLY238R, GLY276R, GLY353A, GLY355A, HIS269R, HIS387A, HIS41A, ILE127R, ILE135R, ILE233R, ILE277R, ILE278R, ILE325R, ILE348A, ILE382A, ILE383A, LEU144R, LEU145R, LEU230R, LEU272R, LEU275R, LEU346A, LEU388A, LEU393A, LEU394A, LEU43A, LYS140R, LYS147R, LYS216A, LYS227R, LYS232R, LYS235R, LYS267R, LYS270R, LYS273R, LYS34A, MET386A, PHE133R, PHE139R, PHE219A, PHE223R, PHE332R, PHE345A, PHE376A, PRO138A, PRO138R, PRO321A, PRO330R, PRO361A, SER137R, SER143R, SER236R, SER329R, SER349A, THR136R, THR146R, THR242A, THR274R, THR325A, THR350A, THR40A, THR66R, THR68R, TYR132R, TYR141R, TYR219R, TYR318A, TYR326R, TYR339A, TYR358A, TYR360A, TYR37A, TYR391A, VAL214A, VAL217A, VAL222R, VAL36A, VAL375A, VAL67R
• A-N: ALA101N, ALA116N, ALA40N, ARG105N, ARG118N, ARG228A, ARG231A, ARG232A, ARG265A, ARG280A, ARG283A, ARG317A, ARG347A, ARG38N, ARG67N, ARG98N, ASN254A, ASN264A, ASN271A, ASN278A, ASN279A, ASN35N, ASP106N, ASP109N, ASP229A, ASP310A, ASP50N, CYS107N, CYS99N, GLN236A, GLN267A, GLN39N, GLU230A, GLU268A, GLU309A, GLU314A, GLU344A, GLU46N, GLU89N, GLY44N, GLY62N, GLY66N, ILE235A, ILE276A, ILE308A, ILE58N, LEU270A, LEU272A, LEU282A, LEU45N, LEU46A, LYS233A, LYS274A, LYS33N, LYS43N, LYS65N, LYS87N, MET255A, PHE103N, PHE108N, PHE273A, PHE312A, PRO100N, PRO313A, SER112N, SER275A, SER352A, SER49N, SER57N, SER59N, SER63N, THR104N, THR111N, THR113N, THR114N, THR263A, THR61N, TRP234A, TRP277A, TRP281A, TRP47N, TYR115N, TYR117N, TYR311A, TYR60N, VAL110N, VAL37N, VAL48N, VAL64N
• B-G: ALA10G, ALA11B, ALA12G, ALA21B, ALA23G, ALA240B, ALA24B, ALA257B, ALA26B, ALA28B, ALA299B, ALA305B, ALA326B, ALA328B, ALA33G, ALA34G, ALA35G, ALA39G, ALA43G, ALA45G, ALA56G, ALA7G, ARG13G, ARG19B, ARG219B, ARG22B, ARG256B, ARG27G, ARG283B, ARG46B, ARG48B, ARG49B, ARG62G, ARG68B, ARG8B, ASN16B, ASN237B, ASN239B, ASN24G, ASN340B, ASN35B, ASN36B, ASN59G, ASN5G, ASP20B, ASP254B, ASP258B, ASP26G, ASP27B, ASP298B, ASP323B, ASP36G, ASP38B, ASP48G, ASP5B, ASP83B, CYS218B, CYS25B, CYS41G, GLN11G, GLN13B, GLN17B, GLN18G, GLN220B, GLN259B, GLN32B, GLN44B, GLN6B, GLN9B, GLU10B, GLU12B, GLU17G, GLU215B, GLU22G, GLU260B, GLU3B, GLU42G, GLU47G, GLU58G, GLY182B, GLY238B, GLY282B, GLY319B, GLY324B, HIS183B, HIS44G, ILE18B, ILE25G, ILE28G, ILE338B, ILE33B, ILE37B, ILE43B, ILE9G, LEU14B, LEU15G, LEU19G, LEU210B, LEU252B, LEU255B, LEU261B, LEU284B, LEU286B, LEU300B, LEU308B, LEU30B, LEU318B, LEU37G, LEU4B, LEU50G, LEU51B, LEU51G, LEU70B, LEU7B, LYS14G, LYS15B, LYS209B, LYS20G, LYS23B, LYS280B, LYS29G, LYS301B, LYS32G, LYS46G, MET217B, MET21G, MET262B, MET325B, MET38G, MET45B, PHE222B, PHE235B, PHE241B, PHE253B, PHE278B, PHE61G, PRO194B, PRO236B, PRO39B, PRO49G, PRO53G, PRO55G, PRO60G, SER277B, SER279B, SER281B, SER31B, SER31G, SER67B, SER84B, SER8G, THR164B, THR181B, THR184B, THR221B, THR223B, THR29B, THR321B, THR34B, THR47B, THR52G, THR6G, THR86B, THR87B, TRP211B, TRP297B, TRP339B, TRP63B, TYR264B, TYR40G, TYR85B, VAL16G, VAL296B, VAL30G, VAL320B, VAL327B, VAL40B, VAL54G
• B-R: ARG52B, ARG63R, ASP312B, ASP331R, ASP333B, GLN65R, GLU62R, GLY310B, HIS311B, ILE334R, LEU64R, LYS337B, PHE335B, PHE61R, THR50B
• B-N: ALA101N, ALA116N, ALA11B, ALA203B, ALA206B, ALA248B, ARG118N, ARG19B, ARG22B, ARG251B, ARG8B, ARG98N, ASN16B, ASN230B, ASN31N, ASP163B, ASP186B, ASP205B, ASP228B, ASP246B, ASP247B, ASP5B, CYS204B, CYS271B, CYS99N, GLN120N, GLN1N, GLN3N, GLN5N, GLN9B, GLU12B, GLU226B, GLU260B, GLY119N, GLY121N, GLY162B, GLY185B, GLY224B, GLY26N, GLY272B, HIS183B, HIS225B, ILE18B, ILE229B, ILE269B, ILE270B, LEU4B, LYS15B, PHE103N, PHE222B, PHE253B, PHE27N, PHE29N, PRO100N, PRO102N, SER207B, SER227B, SER245B, SER25N, THR111N, THR113N, THR114N, THR164B, THR184B, THR221B, THR223B, THR249B, THR28N, TYR115N, TYR117N, TYR32N, TYR95N, VAL2N, VAL93N
• G-N: ASN5G, GLN11G, GLN1N, GLN39N, GLY42N, LEU19G, SER8G, THR113N, THR114N, TYR95N, VAL93N