3SM5

influenza hemagglutinin in complex with a neutralizing antibody

• Total interactions analyzed: 66
• Total true interactions: 24
• Strongest Interaction:
  • Chains: E-N
  • Int. Res.: 31
  • Norm. En. per Res.: -3.5447
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-230.7767	-44.3829	-67.3998	-342.5594	229	81	30	32628	8	60	47
A-C	-21.4387	-23.418	-55.7871	-100.6438	50	5	2	2838	2	18	15
A-D	-2.21	0.0	-72.972	-75.182	41	8	0	2966	0	6	5
A-E	-24.3832	-22.2174	-57.028	-103.6287	50	4	2	2854	2	17	17
A-F	-26.5133	-27.1673	-108.701	-162.3815	58	7	0	4146	2	29	20
A-H	-24.7738	-20.359	-132.678	-177.8108	68	7	5	5354	2	19	13
A-L	-11.2028	-30.3644	-52.1141	-93.6813	34	8	0	2354	4	16	17
B-C	-26.3003	-32.1009	-105.266	-163.6672	58	9	0	4228	2	29	20
B-D	-66.5271	-82.8149	-237.887	-387.2291	129	20	4	12225	10	43	47
B-E	-3.658	0.0	-78.5441	-82.2021	41	5	0	3126	0	7	5
B-F	-46.4479	-97.1448	-258.62	-402.2126	132	20	3	12262	9	48	51
C-D	-201.5006	-45.7114	-194.724	-441.936	229	73	32	33174	8	60	49
C-E	-20.3993	-22.2868	-55.747	-98.4331	50	5	2	2839	2	17	18
C-F	-7.8802	0.0	-60.9629	-68.8431	41	9	0	2987	0	6	5
C-I	-32.8866	-25.4897	-131.082	-189.4583	69	8	4	5283	2	19	12
C-M	-15.5082	-34.5162	-73.6646	-123.6891	37	15	0	2715	4	17	18
D-E	-39.4958	-58.7859	-93.871	-192.1527	56	10	0	4034	1	29	20
D-F	-34.6628	-70.2561	-249.694	-354.6129	129	13	3	12110	9	44	46
E-F	-179.7295	-45.3944	-44.7974	-269.9213	226	56	29	31504	8	59	49
E-J	-13.3014	-16.7804	-130.324	-160.4058	68	4	5	5271	1	18	11
E-N	-10.2228	-32.5803	-67.0838	-109.8869	31	4	0	2400	4	16	17
H-L	-48.2662	-54.9973	-498.224	-601.4876	188	24	10	19093	2	22	26
I-M	-51.3711	-54.1753	-491.476	-597.0223	188	24	10	19063	2	22	26
J-N	-49.4061	-54.2351	-499.389	-603.0302	189	25	10	19128	2	22	26

Interface residues

• A-B: ALA100A, ALA13A, ALA280A, ALA313A, ALA505B, ALA507B, ALA535B, ALA536B, ALA544B, ALA565B, ALA596B, ALA630B, ARG106A, ARG311A, ARG316A, ARG322A, ARG606B, ASN14A, ASN15A, ASN270A, ASN27A, ASN297A, ASN323A, ASN35A, ASN528B, ASN553B, ASN560B, ASN571B, ASN581B, ASN595B, ASN604B, ASN614B, ASN617B, ASN635B, ASN645B, ASN669B, ASP101A, ASP21A, ASP519B, ASP537B, ASP585B, ASP586B, ASP590B, ASP5A, ASP609B, ASP612B, ASP646B, CB5.82448-23.44061, CB5.9671638.03670, CB8.65018-5.80645, CB9.392069.04458, CB9.75507-3.40109, CYS282A, CYS306A, CYS637B, CYS644B, CYS648B, CYS8A, GLN283A, GLN296A, GLN527B, GLN530B, GLN562B, GLN625B, GLU103A, GLU104A, GLU107A, GLU25A, GLU305A, GLU4A, GLU4A5, GLU511B, GLU529B, GLU557B, GLU569B, GLU574B, GLU597B, GLU603B, GLU605B, GLU620B, GLU639B, GLU650B, GLU85A, GLY10A, GLY265A, GLY267A, GLY304A, GLY320A, GLY501B, GLY508B, GLY512B, GLY513B, GLY516B, GLY520B, GLY523B, GLY533B, GLY567B, GLY587B, GLY634B, GLY636B, HIS12A, HIS299A, HIS32A, HIS525B, HIS526B, HIS611B, HIS642B, HIS98A, ILE268A, ILE303A, ILE324A, ILE506B, ILE510B, ILE545B, ILE548B, ILE556B, ILE589B, ILE591B, ILE633B, ILE7A, ILE9A, LEU105A, LEU24A, LEU293A, LEU315A, LEU321A, LEU36A, LEU37A, LEU48A, LEU502B, LEU573B, LEU598B, LEU599B, LEU601B, LEU602B, LEU608B, LEU618B, LEU626B, LYS26A, LYS281A, LYS308A, LYS314A, LYS49A, LYS551B, LYS558B, LYS568B, LYS572B, LYS582B, LYS616B, LYS621B, LYS623B, LYS631B, LYS643B, LYS653B, MET317A, MET517B, MET559B, MET649B, PHE264A, PHE295A, PHE509B, PHE563B, PHE570B, PHE588B, PHE610B, PHE638B, PHE640B, PHE99A, PRO285A, PRO294A, PRO300A, PRO307A, PRO325A, SER110A, SER111A, SER266A, SER291A, SER292A, SER312A, SER326A, SER33A, SER540B, SER554B, SER651B, SER81A, THR19A, THR22A, THR29A, THR302A, THR319A, THR31A, THR515B, THR541B, THR549B, THR561B, THR564B, THR593B, THR607B, THR6A, TRP514B, TRP521B, TRP592B, TYR102A, TYR11A, TYR309A, TYR522B, TYR524B, TYR534B, TYR594B, TYR619B, TYR641B, TYR82A, VAL20A, VAL23A, VAL28A, VAL301A, VAL30A, VAL310A, VAL318A, VAL34A, VAL518B, VAL552B, VAL555B, VAL566B, VAL600B, VAL615B, VAL61A, VAL622B, VAL652B
• A-C: ALA169C, ALA200A, ALA218A, ARG211A, ARG211C, ARG220A, ARG229A, ARG311A, ASN170C, ASN231A, ASP241C, GLU216A, GLU238C, GLU246C, GLY240C, GLY97A, HIS184A, HIS208C, HIS98A, ILE217A, ILE243C, ILE244C, LEU237C, LYS212A, LYS212C, LYS219A, LYS308C, MET317C, PHE213A, PHE99A, PRO215A, PRO221A, PRO96A, SER165C, SER167C, SER203C, SER206C, SER207C, SER210C, THR214A, THR214C, THR242C, TYR201A, TYR201C, TYR209C, TYR233A, VAL182A, VAL205C, VAL223A, VAL23A
• A-D: ALA313A, ALA544D, ARG311A, ARG606D, ASN27A, ASN543D, ASN546D, ASN550D, ASN553D, ASN560D, ASN614D, ASP21A, GLN562D, GLU25A, GLU557D, GLU603D, GLY547D, ILE545D, ILE548D, LEU24A, LEU315A, LEU599D, LYS26A, LYS314A, LYS551D, LYS558D, MET559D, PHE563D, PHE610D, SER312A, SER554D, THR22A, THR549D, THR561D, THR564D, THR607D, TYR309A, VAL23A, VAL310A, VAL552D, VAL555D
• A-E: ALA169A, ALA200E, ALA218E, ARG211A, ARG211E, ARG220E, ARG229E, ARG311E, ASN170A, ASN231E, ASP241A, GLU216E, GLU238A, GLU246A, GLY240A, GLY97E, HIS184E, HIS208A, HIS98E, ILE217E, ILE243A, ILE244A, LEU237A, LYS212A, LYS212E, LYS219E, LYS308A, MET317A, PHE213E, PHE99E, PRO215E, PRO221E, PRO96E, SER165A, SER167A, SER203A, SER206A, SER207A, SER210A, THR214E, THR242A, TYR168A, TYR201A, TYR209A, TYR233E, VAL182E, VAL204A, VAL205A, VAL223E, VAL23E
• A-F: ALA100A, ARG106A, ARG262A, ARG575F, ARG576F, ASN571F, ASN579F, ASN595F, ASP101A, ASP586F, ASP590F, CYS306A, GLN108A, GLU103A, GLU104A, GLU107A, GLU175A, GLU238A, GLU574F, GLU578F, GLY263A, GLY265A, GLY267A, GLY587F, HIS208A, ILE591F, LEU105A, LEU109A, LEU236A, LEU36A, LEU573F, LEU580F, LEU598F, LEU602F, LYS308A, LYS572F, LYS582F, LYS583F, MET317A, MET577F, PHE264A, PHE295A, PHE588F, PRO294A, PRO300A, SER110A, SER111A, SER207A, SER210A, SER266A, THR235A, THR302A, TRP234A, TYR102A, TYR209A, TYR594F, VAL112A, VAL301A
• A-H: ALA137A, ALA193A, ARG104H, ARG192A, ARG226A, ASN158A, ASN54H, ASN59H, ASP107H, ASP190A, ASP225A, ASP31H, ASP57H, CYS139A, GLN191A, GLN65H, GLU102H, GLU227A, GLY134A, GLY156A, GLY159A, GLY189A, GLY228A, GLY56H, HIS183A, HIS196A, HIS33H, HIS52H, ILE188A, ILE230A, ILE252A, LEU154A, LEU160A, LEU194A, LYS157A, PHE147A, PRO103H, PRO162A, PRO185A, PRO186A, PRO53H, SER105H, SER136A, SER138A, SER145A, SER146A, SER55H, THR131A, THR133A, THR155A, THR197A, THR28H, THR30H, THR58H, TRP153A, TRP47H, TRP50H, TYR108H, TYR109H, TYR110H, TYR111H, TYR161A, TYR195A, TYR32H, TYR60H, TYR95A, VAL106H, VAL135A
• A-L: ALA137A, ALA193A, ARG192A, ARG224A, ARG226A, ARG229A, ARG29L, ASN187A, ASN25L, ASP190A, ASP225A, ASP26L, ASP91L, ASP95L, GLN191A, GLU227A, GLY189A, GLY228A, GLY28L, HIS96L, ILE188A, ILE217A, LEU194A, LYS219A, LYS222A, PRO185A, PRO186A, SER138A, SER92L, SER93L, SER94L, TRP90L, TYR95A, VAL223A
• B-C: ALA100C, ARG106C, ARG262C, ARG575B, ARG576B, ASN571B, ASN579B, ASN595B, ASP101C, ASP586B, ASP590B, CYS306C, GLN108C, GLU103C, GLU104C, GLU107C, GLU175C, GLU238C, GLU574B, GLU578B, GLY263C, GLY265C, GLY267C, GLY587B, HIS208C, ILE591B, LEU105C, LEU109C, LEU236C, LEU260C, LEU36C, LEU573B, LEU580B, LEU598B, LEU602B, LYS308C, LYS572B, LYS582B, LYS583B, MET317C, MET577B, PHE264C, PHE295C, PHE588B, PRO294C, PRO300C, SER110C, SER111C, SER207C, SER210C, SER266C, THR235C, TRP234C, TYR102C, TYR209C, TYR594B, VAL112C, VAL301C
• B-D: ALA505B, ALA565D, ALA596B, ALA596D, ARG575B, ARG576B, ARG606B, ARG606D, ARG670B, ARG670D, ASN550D, ASN553D, ASN560D, ASN571D, ASN579B, ASN579D, ASN581B, ASN581D, ASN595B, ASN595D, ASN604B, ASN614D, ASN617D, ASN628D, ASN635B, ASP585B, ASP585D, ASP586B, ASP586D, ASP590B, ASP590D, ASP609B, ASP609D, ASP612B, ASP612D, GLN562D, GLU557D, GLU569D, GLU574B, GLU574D, GLU578B, GLU578D, GLU597B, GLU603B, GLU603D, GLU605B, GLU620D, GLU632B, GLU671B, GLY501B, GLY504B, GLY508B, GLY567D, GLY587B, GLY587D, GLY634B, HIS611D, ILE506B, ILE556D, ILE589B, ILE589D, ILE591B, ILE591D, ILE633B, ILE673B, LEU502B, LEU502D, LEU580B, LEU580D, LEU598B, LEU599B, LEU599D, LEU601B, LEU602B, LEU602D, LEU608B, LEU608D, LYS551D, LYS558D, LYS568D, LYS582B, LYS582D, LYS583B, LYS583D, LYS616B, LYS616D, LYS621D, LYS623B, LYS623D, LYS627D, LYS631B, LYS667D, LYS672B, MET559D, MET577B, MET577D, PHE503B, PHE503D, PHE509B, PHE563D, PHE570B, PHE570D, PHE588B, PHE588D, PHE610B, PHE610D, SER554D, SER613B, SER613D, SER624D, SER663D, THR561D, THR564D, THR593B, THR607B, THR607D, TRP592B, TRP592D, TYR594B, TYR594D, TYR619B, TYR659D, VAL552D, VAL555D, VAL566D, VAL584B, VAL584D, VAL600B, VAL600D
• B-E: ALA313E, ALA544B, ARG311E, ARG606B, ASN27E, ASN543B, ASN546B, ASN550B, ASN553B, ASN560B, ASN614B, ASP21E, GLN562B, GLU25E, GLU557B, GLU603B, GLY547B, ILE545B, ILE548B, LEU24E, LEU315E, LEU599B, LYS26E, LYS314E, LYS551B, LYS558B, MET559B, PHE563B, PHE610B, SER312E, SER554B, THR22E, THR549B, THR561B, THR564B, THR607B, TYR309E, VAL23E, VAL310E, VAL552B, VAL555B
• B-F: ALA505F, ALA565B, ALA596B, ALA596F, ARG575F, ARG576F, ARG606B, ARG606F, ARG670B, ARG670F, ASN543B, ASN550B, ASN553B, ASN560B, ASN571B, ASN579B, ASN579F, ASN581B, ASN581F, ASN595B, ASN595F, ASN604F, ASN614B, ASN617B, ASN628B, ASN635F, ASP585B, ASP585F, ASP586B, ASP586F, ASP590B, ASP590F, ASP609B, ASP609F, ASP612B, ASP612F, GLN562B, GLN625B, GLU557B, GLU569B, GLU574B, GLU574F, GLU578B, GLU578F, GLU597F, GLU603B, GLU603F, GLU605F, GLU620B, GLU632F, GLU671F, GLY501F, GLY504F, GLY508F, GLY547B, GLY567B, GLY587B, GLY587F, GLY634F, HIS611B, ILE506F, ILE556B, ILE589B, ILE589F, ILE591B, ILE591F, ILE633F, ILE673F, LEU502B, LEU502F, LEU580B, LEU580F, LEU598B, LEU598F, LEU599B, LEU599F, LEU601F, LEU602B, LEU602F, LEU608F, LYS551B, LYS558B, LYS568B, LYS582B, LYS582F, LYS583B, LYS583F, LYS616B, LYS616F, LYS621B, LYS623B, LYS623F, LYS627B, LYS631F, LYS667B, LYS672F, MET559B, MET577B, MET577F, PHE503B, PHE503F, PHE509F, PHE563B, PHE570B, PHE570F, PHE588B, PHE588F, PHE610B, PHE610F, SER554B, SER613B, SER613F, SER624B, SER663B, THR561B, THR564B, THR593B, THR593F, THR607F, TRP592B, TRP592F, TYR594F, TYR619F, TYR641F, TYR659B, VAL552B, VAL555B, VAL566B, VAL584B, VAL584F, VAL600B, VAL600F
• C-D: ALA100C, ALA13C, ALA280C, ALA313C, ALA505D, ALA507D, ALA535D, ALA536D, ALA544D, ALA565D, ALA596D, ALA630D, ARG106C, ARG311C, ARG316C, ARG322C, ARG606D, ASN14C, ASN15C, ASN270C, ASN27C, ASN297C, ASN323C, ASN35C, ASN528D, ASN553D, ASN560D, ASN571D, ASN581D, ASN595D, ASN604D, ASN614D, ASN617D, ASN635D, ASN645D, ASN669D, ASP101C, ASP21C, ASP519D, ASP537D, ASP585D, ASP586D, ASP590D, ASP5C, ASP609D, ASP612D, ASP646D, CYS282C, CYS306C, CYS637D, CYS644D, CYS648D, CYS8C, GLN283C, GLN296C, GLN527D, GLN530D, GLN562D, GLN625D, GLU103C, GLU104C, GLU107C, GLU25C, GLU305C, GLU4C, GLU511D, GLU529D, GLU557D, GLU569D, GLU574D, GLU597D, GLU603D, GLU605D, GLU620D, GLU632D, GLU639D, GLU650D, GLU665D, GLU85C, GLY10C, GLY265C, GLY267C, GLY304C, GLY320C, GLY501D, GLY504D, GLY508D, GLY512D, GLY513D, GLY516D, GLY520D, GLY523D, GLY533D, GLY567D, GLY587D, GLY634D, GLY636D, HIS12C, HIS299C, HIS32C, HIS525D, HIS526D, HIS611D, HIS642D, HIS98C, ILE268C, ILE269C, ILE303C, ILE324C, ILE506D, ILE510D, ILE51C, ILE545D, ILE548D, ILE556D, ILE589D, ILE591D, ILE633D, ILE7C, ILE9C, LEU105C, LEU24C, LEU293C, LEU315C, LEU321C, LEU36C, LEU37C, LEU48C, LEU502D, LEU573D, LEU598D, LEU599D, LEU601D, LEU602D, LEU608D, LEU618D, LEU626D, LYS26C, LYS281C, LYS308C, LYS314C, LYS49C, LYS551D, LYS558D, LYS568D, LYS572D, LYS582D, LYS616D, LYS621D, LYS623D, LYS631D, LYS643D, LYS653D, MET317C, MET517D, MET559D, MET577D, MET649D, PHE264C, PHE295C, PHE509D, PHE563D, PHE570D, PHE588D, PHE610D, PHE638D, PHE640D, PHE99C, PRO285C, PRO294C, PRO300C, PRO307C, PRO325C, SER110C, SER111C, SER266C, SER291C, SER292C, SER312C, SER326C, SER33C, SER554D, SER651D, SER81C, THR19C, THR22C, THR29C, THR302C, THR319C, THR31C, THR515D, THR541D, THR549D, THR561D, THR564D, THR593D, THR607D, THR6C, TRP514D, TRP521D, TRP592D, TYR102C, TYR11C, TYR309C, TYR522D, TYR524D, TYR534D, TYR594D, TYR619D, TYR641D, TYR657D, TYR82C, VAL20C, VAL23C, VAL28C, VAL301C, VAL30C, VAL310C, VAL318C, VAL34C, VAL518D, VAL552D, VAL555D, VAL566D, VAL600D, VAL615D, VAL61C, VAL622D, VAL652D
• C-E: ALA169E, ALA200C, ALA218C, ARG211C, ARG211E, ARG220C, ARG229C, ARG311C, ASN170E, ASN231C, ASP241E, GLU216C, GLU238E, GLU246E, GLY240E, GLY97C, HIS184C, HIS208E, HIS98C, ILE217C, ILE243E, ILE244E, LEU237E, LYS212C, LYS212E, LYS219C, LYS308E, MET317E, PHE213C, PHE99C, PRO215C, PRO221C, PRO96C, SER165E, SER167E, SER203E, SER206E, SER207E, SER210E, THR214C, THR214E, THR242E, TYR201E, TYR209E, TYR233C, VAL182C, VAL204E, VAL205E, VAL223C, VAL23C
• C-F: ALA313C, ALA544F, ARG311C, ARG606F, ASN543F, ASN546F, ASN550F, ASN553F, ASN560F, ASN614F, ASP21C, GLN562F, GLU25C, GLU557F, GLU603F, GLY547F, ILE545F, ILE548F, LEU24C, LEU315C, LEU599F, LYS26C, LYS314C, LYS551F, LYS558F, MET559F, PHE563F, PHE610F, PRO300C, SER312C, SER554F, THR22C, THR549F, THR561F, THR564F, THR607F, TYR309C, VAL23C, VAL310C, VAL552F, VAL555F
• C-I: ALA137C, ALA193C, ARG104I, ARG192C, ARG226C, ASN158C, ASN54I, ASN59I, ASP107I, ASP190C, ASP225C, ASP31I, ASP57I, CYS139C, GLN65I, GLU102I, GLU144C, GLU227C, GLY134C, GLY156C, GLY159C, GLY189C, GLY228C, GLY56I, HIS183C, HIS196C, HIS33I, HIS52I, ILE188C, ILE230C, ILE252C, LEU154C, LEU160C, LEU194C, LYS157C, PHE147C, PRO103I, PRO162C, PRO185C, PRO186C, PRO53I, PRO96C, SER105I, SER136C, SER138C, SER145C, SER146C, SER55I, THR131C, THR133C, THR155C, THR197C, THR28I, THR30I, THR58I, TRP153C, TRP47I, TRP50I, TYR108I, TYR109I, TYR110I, TYR111I, TYR161C, TYR195C, TYR32I, TYR60I, TYR95C, VAL106I, VAL135C
• C-M: ALA137C, ALA193C, ARG192C, ARG220C, ARG224C, ARG226C, ARG229C, ARG29M, ASN187C, ASN25M, ASP190C, ASP225C, ASP26M, ASP91M, ASP95M, GLN191C, GLU198C, GLU227C, GLY189C, GLY228C, GLY28M, GLY67M, HIS96M, ILE188C, ILE217C, LEU194C, LYS219C, LYS222C, PRO185C, PRO186C, SER138C, SER92M, SER93M, SER94M, TRP90M, TYR95C, VAL223C
• D-E: ALA100E, ARG106E, ARG262E, ARG575D, ARG576D, ASN571D, ASN579D, ASN595D, ASP101E, ASP586D, ASP590D, GLN108E, GLU103E, GLU104E, GLU107E, GLU175E, GLU238E, GLU574D, GLU578D, GLY263E, GLY265E, GLY267E, GLY587D, HIS208E, ILE591D, LEU105E, LEU109E, LEU236E, LEU36E, LEU573D, LEU580D, LEU598D, LEU602D, LYS308E, LYS572D, LYS582D, LYS583D, MET317E, MET577D, PHE264E, PHE295E, PHE588D, PRO294E, PRO300E, SER110E, SER111E, SER207E, SER210E, SER266E, THR235E, THR302E, TRP234E, TYR102E, TYR209E, TYR594D, VAL301E
• D-F: ALA505D, ALA565F, ALA596D, ALA596F, ARG575D, ARG576D, ARG576F, ARG606D, ARG606F, ARG670D, ASN550F, ASN553F, ASN560F, ASN571F, ASN579D, ASN579F, ASN581D, ASN581F, ASN595D, ASN595F, ASN604D, ASN614F, ASN617F, ASN635D, ASP585D, ASP585F, ASP586D, ASP586F, ASP590D, ASP609D, ASP609F, ASP612D, ASP612F, GLN562F, GLN625F, GLU557F, GLU569F, GLU574D, GLU574F, GLU578D, GLU578F, GLU597D, GLU603D, GLU603F, GLU605D, GLU620F, GLU632D, GLU671D, GLY501D, GLY504D, GLY508D, GLY567F, GLY587D, GLY587F, GLY634D, HIS611F, ILE556F, ILE589D, ILE589F, ILE591D, ILE591F, ILE633D, ILE673D, LEU502D, LEU502F, LEU580D, LEU580F, LEU598D, LEU598F, LEU599D, LEU599F, LEU601D, LEU602D, LEU602F, LEU608D, LEU608F, LYS551F, LYS558F, LYS568F, LYS582D, LYS582F, LYS583D, LYS583F, LYS616D, LYS616F, LYS621F, LYS623D, LYS623F, LYS627F, LYS631D, LYS667F, LYS672D, MET559F, MET577D, MET577F, PHE503D, PHE503F, PHE509D, PHE563F, PHE570D, PHE570F, PHE588D, PHE588F, PHE610D, PHE610F, SER554F, SER613D, SER613F, SER624F, SER663F, THR561F, THR564F, THR593D, THR607D, THR607F, TRP592D, TRP592F, TYR594D, TYR594F, TYR619D, TYR641D, TYR659F, VAL552F, VAL555F, VAL566F, VAL584D, VAL584F, VAL600D, VAL600F
• E-F: ALA100E, ALA13E, ALA280E, ALA313E, ALA505F, ALA507F, ALA535F, ALA536F, ALA544F, ALA565F, ALA596F, ALA630F, ARG106E, ARG311E, ARG316E, ARG322E, ARG606F, ASN14E, ASN15E, ASN270E, ASN27E, ASN297E, ASN323E, ASN35E, ASN528F, ASN553F, ASN560F, ASN571F, ASN581F, ASN595F, ASN604F, ASN614F, ASN617F, ASN635F, ASN645F, ASN669F, ASP101E, ASP21E, ASP519F, ASP537F, ASP585F, ASP586F, ASP590F, ASP5E, ASP609F, ASP612F, ASP646F, CYS282E, CYS306E, CYS637F, CYS644F, CYS648F, CYS8E, GLN283E, GLN296E, GLN527F, GLN530F, GLN562F, GLN625F, GLU103E, GLU104E, GLU107E, GLU25E, GLU305E, GLU4E, GLU511F, GLU529F, GLU557F, GLU569F, GLU574F, GLU597F, GLU603F, GLU605F, GLU620F, GLU639F, GLU650F, GLU85E, GLY10E, GLY265E, GLY267E, GLY304E, GLY320E, GLY501F, GLY508F, GLY512F, GLY513F, GLY516F, GLY520F, GLY523F, GLY533F, GLY567F, GLY587F, GLY634F, GLY636F, HIS12E, HIS299E, HIS32E, HIS525F, HIS526F, HIS611F, HIS642F, HIS98E, ILE268E, ILE269E, ILE303E, ILE324E, ILE506F, ILE510F, ILE545F, ILE548F, ILE556F, ILE589F, ILE591F, ILE633F, ILE7E, ILE9E, LEU105E, LEU24E, LEU293E, LEU315E, LEU321E, LEU36E, LEU37E, LEU48E, LEU502F, LEU573F, LEU598F, LEU599F, LEU601F, LEU602F, LEU608F, LEU618F, LEU626F, LYS26E, LYS281E, LYS308E, LYS314E, LYS49E, LYS551F, LYS558F, LYS568F, LYS572F, LYS582F, LYS616F, LYS621F, LYS623F, LYS631F, LYS643F, LYS653F, MET317E, MET517F, MET559F, MET577F, MET649F, PHE264E, PHE295E, PHE509F, PHE563F, PHE570F, PHE588F, PHE610F, PHE638F, PHE640F, PHE99E, PRO285E, PRO294E, PRO300E, PRO307E, PRO325E, SER110E, SER111E, SER266E, SER291E, SER292E, SER312E, SER326E, SER33E, SER532F, SER540F, SER554F, SER651F, SER81E, THR19E, THR22E, THR29E, THR302E, THR319E, THR31E, THR515F, THR541F, THR549F, THR561F, THR564F, THR593F, THR607F, THR6E, TRP514F, TRP521F, TRP592F, TYR102E, TYR11E, TYR309E, TYR522F, TYR524F, TYR534F, TYR594F, TYR619F, TYR641F, TYR82E, VAL20E, VAL23E, VAL28E, VAL301E, VAL30E, VAL310E, VAL318E, VAL34E, VAL518F, VAL552F, VAL555F, VAL566F, VAL600F, VAL615F, VAL61E, VAL622F, VAL652F
• E-J: ALA137E, ALA193E, ARG104J, ARG192E, ARG226E, ARG72J, ASN158E, ASN54J, ASN59J, ASP107J, ASP190E, ASP225E, ASP31J, ASP57J, CYS139E, GLN191E, GLN65J, GLU102J, GLU227E, GLY134E, GLY156E, GLY159E, GLY189E, GLY56J, HIS183E, HIS196E, HIS33J, HIS52J, ILE230E, ILE252E, LEU154E, LEU160E, LEU194E, LYS157E, PHE147E, PRO103J, PRO162E, PRO185E, PRO186E, PRO53J, SER105J, SER136E, SER138E, SER145E, SER146E, SER55J, THR131E, THR132E, THR133E, THR155E, THR197E, THR28J, THR30J, THR58J, TRP153E, TRP47J, TRP50J, TYR108J, TYR109J, TYR110J, TYR111J, TYR161E, TYR195E, TYR32J, TYR60J, TYR95E, VAL106J, VAL135E
• E-N: ALA137E, ALA193E, ARG192E, ARG224E, ARG226E, ARG29N, ASN187E, ASP190E, ASP225E, ASP26N, ASP91N, ASP95N, GLN191E, GLU198E, GLU227E, GLY189E, GLY228E, HIS96N, ILE188E, ILE217E, LEU194E, LYS219E, LYS222E, PRO185E, PRO186E, SER92N, SER93N, SER94N, TRP90N, TYR95E, VAL223E
• H-L: ALA129L, ALA132L, ALA138H, ALA149H, ALA150H, ALA175L, ALA176L, ALA181H, ALA40H, ALA42L, ALA61H, ALA97H, ARG104H, ARG223H, ARG29L, ARG38H, ARG53L, ARG98H, ASN171L, ASN35H, ASN35L, ASN59H, ASP107H, ASP114H, ASP140L, ASP157H, ASP50L, ASP52L, ASP84L, ASP91L, ASP95L, CYS136L, CYS153H, CYS48L, CYS87L, CYS96H, GLN118H, GLN128L, GLN169L, GLN184H, GLN36L, GLN37L, GLN39H, GLN41L, GLN43H, GLN62H, GLN65H, GLN6H, GLN88L, GLU102H, GLU125L, GLU126L, GLU162L, GLU225H, GLU46H, GLY100H, GLY100L, GLY101L, GLY102L, GLY112H, GLY117H, GLY119H, GLY152H, GLY160L, GLY187H, GLY40L, GLY42H, GLY44H, GLY49H, GLY99H, HIS177H, HIS33L, HIS96L, ILE138L, ILE27L, ILE98L, LEU101H, LEU119L, LEU127L, LEU134L, LEU137H, LEU137L, LEU151H, LEU154H, LEU180L, LEU182L, LEU183H, LEU188H, LEU191H, LEU45H, LEU45L, LEU4L, LYS104L, LYS130H, LYS131L, LYS156H, LYS168L, LYS173L, LYS206L, LYS222H, LYS227H, LYS30L, LYS63H, MET113H, MET48H, PHE120L, PHE135H, PHE141L, PHE179H, PHE64H, PHE99L, PRO103H, PRO121L, PRO122L, PRO136H, PRO139H, PRO166L, PRO180H, PRO39L, PRO43L, PRO54L, SER105H, SER116L, SER123L, SER124L, SER133H, SER139L, SER140H, SER167L, SER170L, SER177L, SER178L, SER181L, SER185H, SER186H, SER190H, SER192H, SER193H, SER31L, SER51L, SER92L, SER94L, THR118L, THR133L, THR163L, THR164L, THR165L, THR178H, THR196H, THR211L, TRP116H, TRP34L, TRP36H, TRP47H, TRP50H, TRP90L, TYR108H, TYR109H, TYR110H, TYR111H, TYR174L, TYR179L, TYR189H, TYR49L, TYR60H, TYR85L, TYR86L, TYR95H, VAL106H, VAL115H, VAL117L, VAL134H, VAL135L, VAL155H, VAL161L, VAL176H, VAL182H, VAL194H, VAL195H, VAL224H, VAL32L, VAL37H, VAL44L, VAL46L, VAL47L, VAL89L, VAL93H, VAL97L
• I-M: ALA129M, ALA132M, ALA138I, ALA149I, ALA150I, ALA175M, ALA176M, ALA181I, ALA40I, ALA42M, ALA61I, ALA97I, ARG104I, ARG223I, ARG29M, ARG38I, ARG53M, ARG98I, ASN171M, ASN35I, ASN35M, ASN59I, ASP107I, ASP114I, ASP140M, ASP157I, ASP50M, ASP52M, ASP84M, ASP91M, ASP95M, CYS136M, CYS153I, CYS48M, CYS87M, CYS96I, GLN118I, GLN128M, GLN169M, GLN184I, GLN36M, GLN37M, GLN39I, GLN41M, GLN43I, GLN62I, GLN65I, GLN6I, GLN88M, GLU102I, GLU125M, GLU126M, GLU162M, GLU225I, GLU46I, GLY100I, GLY100M, GLY101M, GLY102M, GLY112I, GLY117I, GLY119I, GLY152I, GLY160M, GLY187I, GLY40M, GLY42I, GLY44I, GLY49I, GLY99I, HIS177I, HIS33M, HIS96M, ILE138M, ILE27M, ILE98M, LEU101I, LEU119M, LEU127M, LEU134M, LEU137I, LEU137M, LEU151I, LEU154I, LEU180M, LEU182M, LEU183I, LEU188I, LEU191I, LEU45I, LEU45M, LEU4M, LYS104M, LYS130I, LYS131M, LYS156I, LYS168M, LYS173M, LYS206M, LYS222I, LYS227I, LYS30M, LYS63I, MET113I, MET48I, PHE120M, PHE135I, PHE141M, PHE179I, PHE64I, PHE99M, PRO103I, PRO121M, PRO122M, PRO136I, PRO139I, PRO166M, PRO180I, PRO39M, PRO43M, PRO54M, SER105I, SER116M, SER123M, SER124M, SER133I, SER139M, SER140I, SER167M, SER170M, SER177M, SER178M, SER181M, SER185I, SER186I, SER190I, SER192I, SER193I, SER31M, SER51M, SER92M, SER94M, THR118M, THR133M, THR163M, THR164M, THR165M, THR178I, THR196I, THR211M, TRP116I, TRP34M, TRP36I, TRP47I, TRP50I, TRP90M, TYR108I, TYR109I, TYR110I, TYR111I, TYR174M, TYR179M, TYR189I, TYR49M, TYR60I, TYR85M, TYR86M, TYR95I, VAL106I, VAL115I, VAL117M, VAL134I, VAL135M, VAL155I, VAL161M, VAL176I, VAL182I, VAL194I, VAL195I, VAL224I, VAL32M, VAL37I, VAL44M, VAL46M, VAL47M, VAL89M, VAL93I, VAL97M
• J-N: ALA129N, ALA132N, ALA138J, ALA149J, ALA150J, ALA175N, ALA176N, ALA181J, ALA40J, ALA42N, ALA61J, ALA97J, ARG104J, ARG223J, ARG29N, ARG38J, ARG53N, ARG98J, ASN171N, ASN35J, ASN35N, ASN59J, ASP107J, ASP114J, ASP140N, ASP157J, ASP50N, ASP52N, ASP84N, ASP91N, ASP95N, CYS136N, CYS153J, CYS48N, CYS87N, CYS96J, GLN118J, GLN128N, GLN169N, GLN184J, GLN36N, GLN37N, GLN39J, GLN41N, GLN43J, GLN62J, GLN65J, GLN6J, GLN88N, GLU102J, GLU125N, GLU126N, GLU162N, GLU225J, GLU46J, GLY100J, GLY100N, GLY101N, GLY102N, GLY112J, GLY117J, GLY119J, GLY152J, GLY160N, GLY187J, GLY40N, GLY42J, GLY44J, GLY49J, GLY99J, HIS177J, HIS33N, HIS96N, ILE138N, ILE27N, ILE98N, LEU101J, LEU119N, LEU127N, LEU134N, LEU137J, LEU137N, LEU151J, LEU154J, LEU180N, LEU182N, LEU183J, LEU188J, LEU191J, LEU45J, LEU45N, LEU4N, LYS104N, LYS130J, LYS131N, LYS156J, LYS168N, LYS173N, LYS206N, LYS222J, LYS227J, LYS30N, LYS63J, MET113J, MET48J, PHE120N, PHE135J, PHE141N, PHE179J, PHE64J, PHE99N, PRO103J, PRO121N, PRO122N, PRO136J, PRO139J, PRO166N, PRO180J, PRO39N, PRO41J, PRO43N, PRO54N, SER105J, SER116N, SER123N, SER124N, SER133J, SER139N, SER140J, SER167N, SER170N, SER177N, SER178N, SER181N, SER185J, SER186J, SER190J, SER192J, SER193J, SER31N, SER51N, SER92N, SER94N, THR118N, THR133N, THR163N, THR164N, THR165N, THR178J, THR196J, THR211N, TRP116J, TRP34N, TRP36J, TRP47J, TRP50J, TRP90N, TYR108J, TYR109J, TYR110J, TYR111J, TYR174N, TYR179N, TYR189J, TYR49N, TYR60J, TYR85N, TYR86N, TYR95J, VAL106J, VAL115J, VAL117N, VAL134J, VAL135N, VAL155J, VAL161N, VAL176J, VAL182J, VAL194J, VAL195J, VAL224J, VAL32N, VAL37J, VAL44N, VAL46N, VAL47N, VAL89N, VAL93J, VAL97N