3SHM

structure-function analysis of receptor binding in adeno-associated virus serotype 6 (aav-6)

• Total interactions analyzed: 190
• Total true interactions: 45
• Strongest Interaction:
  • Chains: D-E
  • Int. Res.: 340
  • Norm. En. per Res.: -5.0857
• Hub Node: B(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-G	-77.9503	-12.6378	-615.702	-706.2901	201	38	13	24985	1	18	17
A-M	-74.0141	-12.6684	-401.393	-488.0756	154	30	9	16968	1	13	13
B-C	-77.9056	-12.5173	-619.776	-710.1989	200	41	13	25073	1	18	17
B-E	0.0	0.0	-0.0209	-0.0209	7	0	0	21	0	0	0
B-G	-267.3211	-47.2538	-1416.75	-1731.3249	341	142	27	57436	4	64	62
B-H	0.0	0.0	-7.1509	-7.1509	11	0	2	460	0	0	1
B-N	-73.3465	-12.7041			23
C-E	-92.612	-12.8541	-628.857	-734.3231	201	38	13	25127	1	18	17
C-G	0.0	0.0	-7.1415	-7.1415	11	0	2	457	0	0	1
D-E	-257.0063	-46.0931	-1426.05	-1729.1494	340	140	27	57259	4	64	61
D-F	0.0	0.0	-6.8542	-6.8542	11	0	2	446	0	0	1
D-I	-71.7879	-12.6415	-620.707	-705.1364	203	43	13	25062	1	18	17
D-J	0.0	0.0	-0.0998	-0.0998	7	0	0	48	0	0	0
D-L	-87.4697	-12.651	-617.913	-718.0337	201	39	13	25009	1	18	17
E-I	-50.6357	-163.6985	-349.966	-564.3002	136	25	2	14330	14	32	35
E-L	0.0	0.0	-6.7974	-6.7974	11	0	2	452	0	0	1
E-P	-87.0943	-12.8485			25
F-H	-76.9748	-12.7298	-620.561	-710.2656	201	38	13	25005	1	18	17
F-I	-242.5442	-47.0758	-1406.58	-1696.2	341	142	27	57477	4	65	61
F-K	-92.2814	-12.8527	-626.27	-731.4041	202	40	13	25190	1	18	17
F-P	-257.2348	-48.2515			68
F-R	-52.3257	-165.5533			26
G-M	0.0	0.0	-0.0291	-0.0291	7	0	0	25	0	0	0
G-N	-50.5893	-162.3413			26
G-Q	-83.998	-12.8819			25
H-K	0.0	0.0	-0.0263	-0.0263	7	0	0	23	0	0	0
H-N	-273.337	-47.8655			70
H-O	-81.5028	-12.6035			21
H-P	-41.2343	-163.4727			24
H-Q	-264.4543	-46.4298			66
I-J	0.0	0.0	-0.0264	-0.0264	7	0	0	25	0	0	0
I-L	0.0	0.0	-0.0257	-0.0257	7	0	0	23	0	0	0
I-P	-259.2933	-47.9915			68
I-R	-90.675	-12.6236			25
J-L	-114.1487	-18.2831	-689.308	-821.7398	216	92	16	28326	2	18	17
J-R	-80.8488	-12.8476			19
K-R	-255.6769	-46.8528			67
K-S	-83.6622	-12.8274			25
M-T	-73.4559	-12.7171			21
N-P	-76.4306	-12.3032			24
N-Q	-245.9209	-47.033			67
O-Q	-49.8268	-163.0669			26
O-S	-72.3894	-12.9264			23
O-T	-245.0138	-46.659			67
Q-T	-88.1504	-12.6149			25

Interface residues

• A-G: ALA224A, ALA248A, ALA263G, ALA334A, ALA334G, ALA368A, ALA387G, ALA656G, ALA660G, ALA664G, ALA668G, ALA706A, ALA709A, ARG245A, ARG295A, ARG299A, ARG390G, ARG405A, ARG405G, ASN223A, ASN223G, ASN227A, ASN253A, ASN253G, ASN254A, ASN318A, ASN327G, ASN335A, ASN335G, ASN336A, ASN336G, ASN382G, ASN383G, ASN408A, ASN408G, ASN409G, ASN651A, ASN657G, ASN704A, ASN710A, ASN717A, ASN718A, ASP231A, ASP296A, ASP328A, ASP328G, ASP369A, ASP712A, ASP716A, CYS230A, CYS362A, CYS395G, GLN259G, GLN320A, GLN342G, GLN350G, GLN360A, GLN375A, GLN386G, GLN402G, GLN673A, GLN673G, GLN678A, GLU323A, GLU323G, GLU348G, GLU397G, GLU546A, GLU661G, GLY222A, GLY222G, GLY226A, GLY275G, GLY329A, GLY361A, GLY384G, GLY389G, GLY407A, GLY407G, GLY677A, GLY719A, HIS229A, HIS255G, HIS291A, HIS359A, ILE240A, ILE260G, ILE319A, ILE319G, ILE333A, ILE373A, ILE671G, LEU249A, LEU256G, LEU337A, LEU337G, LEU381G, LEU396G, LEU404G, LEU720A, LYS258G, LYS322A, LYS650G, LYS666G, LYS707A, MET372A, MET403G, PHE274G, PHE292A, PHE317A, PHE344G, PHE366A, PHE371A, PHE393G, PHE399G, PHE662G, PHE667G, PHE670G, PHE713A, PRO250A, PRO279G, PRO294A, PRO364A, PRO365A, PRO367A, PRO374A, PRO400G, PRO653G, PRO655G, PRO658G, PRO659G, SER225A, SER232A, SER243A, SER261G, SER277G, SER293A, SER339G, SER385G, SER391G, SER392G, SER401G, SER663G, SER669G, SER675A, SER703A, SER708A, THR233A, THR241A, THR242A, THR244A, THR246A, THR251A, THR278G, THR325A, THR325G, THR326A, THR326G, THR331A, THR332A, THR332G, THR338G, THR340G, THR380G, THR406A, THR406G, THR652G, THR665G, THR672A, THR672G, THR676A, THR702A, THR714A, TRP228A, TRP234A, TRP247A, TRP280G, TYR252A, TYR257G, TYR276G, TYR282A, TYR378G, TYR394G, TYR398G, TYR674A, TYR705A, TYR721A, VAL221A, VAL221G, VAL321A, VAL321G, VAL324A, VAL330A, VAL341G, VAL343G, VAL370A, VAL388G, VAL654G, VAL679A, VAL711A, VAL715A
• A-M: ALA224M, ALA248M, ALA334A, ALA334M, ALA368M, ALA387A, ALA656A, ALA660A, ALA664A, ALA668A, ALA709M, ARG245M, ARG295M, ARG299M, ARG405A, ARG405M, ASN223A, ASN223M, ASN227M, ASN253M, ASN254M, ASN318M, ASN327A, ASN335A, ASN335M, ASN336A, ASN336M, ASN408A, ASN408M, ASN409A, ASN657A, ASP231M, ASP296M, ASP328A, ASP328M, ASP369M, ASP716M, CYS230M, CYS362M, CYS395A, GLN259A, GLN320M, GLN342A, GLN350A, GLN360M, GLN375M, GLN402A, GLN673A, GLU323A, GLU323M, GLU348A, GLU397A, GLU661A, GLY222A, GLY222M, GLY226M, GLY329M, GLY361M, GLY407A, GLY407M, HIS229M, HIS255A, HIS291M, HIS359M, ILE240M, ILE319A, ILE319M, ILE333M, ILE373M, ILE671A, LEU249M, LEU256A, LEU337A, LEU337M, LEU396A, LEU404A, LYS258A, LYS322M, LYS650A, LYS666A, MET372M, MET403A, PHE292M, PHE317M, PHE344A, PHE366M, PHE371M, PHE393A, PHE399A, PHE662A, PHE667A, PHE670A, PRO250M, PRO279A, PRO294M, PRO364M, PRO365M, PRO367M, PRO374M, PRO400A, PRO653A, PRO655A, PRO658A, PRO659A, SER225M, SER232M, SER243M, SER293M, SER339A, SER401A, SER663A, SER669A, SER708M, THR233M, THR241M, THR242M, THR244M, THR246M, THR251M, THR278A, THR325A, THR325M, THR326A, THR326M, THR331M, THR332A, THR332M, THR338A, THR340A, THR406A, THR406M, THR652A, THR665A, THR672A, TRP228M, TRP234M, TRP247M, TRP280A, TYR252M, TYR257A, TYR282M, TYR376M, TYR394A, TYR398A, VAL221A, VAL221M, VAL321A, VAL321M, VAL324M, VAL330M, VAL341A, VAL343A, VAL370M, VAL654A
• B-C: ALA224B, ALA248B, ALA263C, ALA334B, ALA334C, ALA368B, ALA387C, ALA656C, ALA660C, ALA664C, ALA668C, ALA706B, ALA709B, ARG245B, ARG295B, ARG299B, ARG390C, ARG405B, ARG405C, ASN223B, ASN223C, ASN227B, ASN253B, ASN253C, ASN254B, ASN318B, ASN327C, ASN335B, ASN335C, ASN336B, ASN336C, ASN382C, ASN383C, ASN408B, ASN408C, ASN409C, ASN651B, ASN657C, ASN704B, ASN710B, ASN717B, ASN718B, ASP231B, ASP296B, ASP328B, ASP328C, ASP369B, ASP712B, ASP716B, CYS230B, CYS362B, CYS395C, GLN259C, GLN320B, GLN342C, GLN350C, GLN360B, GLN375B, GLN386C, GLN402C, GLN673B, GLN673C, GLN678B, GLU323B, GLU323C, GLU348C, GLU397C, GLU546B, GLU661C, GLY222B, GLY222C, GLY226B, GLY275C, GLY329B, GLY361B, GLY384C, GLY389C, GLY407B, GLY407C, GLY677B, GLY719B, HIS229B, HIS255C, HIS291B, HIS359B, ILE240B, ILE260C, ILE319B, ILE333B, ILE373B, ILE671C, LEU249B, LEU256C, LEU337B, LEU337C, LEU381C, LEU396C, LEU404C, LEU720B, LYS258C, LYS322B, LYS650C, LYS666C, LYS707B, MET372B, MET403C, PHE274C, PHE292B, PHE317B, PHE344C, PHE366B, PHE371B, PHE393C, PHE399C, PHE662C, PHE667C, PHE670C, PHE713B, PRO250B, PRO279C, PRO294B, PRO364B, PRO367B, PRO374B, PRO400C, PRO653C, PRO655C, PRO658C, PRO659C, SER225B, SER232B, SER243B, SER261C, SER277C, SER293B, SER339C, SER385C, SER391C, SER392C, SER401C, SER663C, SER669C, SER675B, SER703B, SER708B, THR233B, THR241B, THR242B, THR244B, THR246B, THR251B, THR278C, THR325B, THR325C, THR326B, THR326C, THR331B, THR332B, THR332C, THR338C, THR340C, THR380C, THR406B, THR406C, THR652C, THR665C, THR672B, THR672C, THR676B, THR702B, THR714B, TRP228B, TRP234B, TRP247B, TRP280C, TYR252B, TYR257C, TYR276C, TYR282B, TYR376B, TYR378C, TYR394C, TYR398C, TYR674B, TYR705B, TYR721B, VAL221B, VAL221C, VAL321B, VAL321C, VAL324B, VAL330B, VAL341C, VAL343C, VAL370B, VAL388C, VAL654C, VAL679B, VAL711B, VAL715B
• B-E: ARG405E, GLY222B, LEU337B, LEU337E, THR338E, VAL221B, VAL221E
• B-G: ALA267B, ALA358B, ALA426G, ALA456G, ALA469G, ALA506B, ALA523B, ALA523G, ALA525G, ALA548B, ALA550B, ALA554B, ALA568G, ALA573B, ALA581G, ALA592G, ALA601B, ALA601G, ALA620B, ARG287B, ARG390B, ARG433G, ARG448G, ARG465G, ARG485B, ARG488B, ARG514B, ARG576B, ARG576G, ARG610B, ARG610G, ARG694G, ARG730G, ARG734G, ASN253B, ASN269B, ASN271B, ASN286B, ASN382B, ASN383B, ASN436G, ASN447G, ASN451G, ASN458G, ASN477G, ASN496B, ASN497B, ASN498B, ASN500B, ASN510B, ASN512B, ASN519B, ASN552B, ASN557B, ASN570B, ASN570G, ASN583G, ASN691G, ASN696G, ASP270B, ASP284B, ASP346B, ASP432G, ASP440G, ASP460G, ASP495B, ASP529G, ASP530G, ASP556B, ASP590G, ASP595B, ASP595G, ASP609B, ASP609G, ASP611G, ASP626B, CYS362B, CYS395B, CYS483B, CYS483G, GLN350B, GLN360B, GLN375B, GLN386B, GLN429G, GLN441G, GLN450G, GLN452G, GLN457G, GLN474G, GLN486B, GLN487B, GLN585G, GLN608B, GLN608G, GLN615B, GLN646B, GLN688G, GLN700G, GLU348B, GLU397B, GLU515B, GLU546B, GLU564G, GLU565G, GLU575B, GLU575G, GLU698G, GLY266B, GLY275B, GLY281B, GLY356B, GLY361B, GLY377B, GLY384B, GLY389B, GLY466G, GLY470G, GLY481B, GLY481G, GLY505B, GLY513B, GLY521B, GLY539B, GLY544B, GLY549B, GLY578G, GLY594G, GLY600B, GLY600G, GLY604G, GLY616B, GLY627B, GLY627G, GLY636B, GLY637B, GLY639B, GLY728G, HIS272B, HIS289B, HIS359B, HIS422G, HIS427G, HIS527G, HIS597B, HIS597G, HIS624B, HIS628B, HIS628G, HIS630B, HIS630G, ILE260B, ILE301G, ILE373B, ILE439G, ILE517B, ILE518B, ILE542B, ILE560B, ILE566G, ILE618B, ILE622B, LEU351B, LEU355B, LEU379B, LEU381B, LEU396B, LEU431G, LEU434G, LEU438G, LEU443G, LEU446G, LEU461G, LEU462G, LEU479G, LEU511B, LEU555B, LEU584G, LEU602B, LEU602G, LEU634B, LEU640B, LEU648B, LEU732G, LEU736G, LYS258B, LYS459G, LYS476G, LYS491B, LYS493B, LYS508B, LYS528B, LYS528G, LYS531B, LYS531G, LYS533B, LYS545B, LYS567G, LYS621B, LYS693G, MET372B, MET435G, MET471G, MET524B, MET537B, MET541B, MET559B, MET599B, MET599G, MET605B, MET605G, MET635B, PHE274B, PHE288B, PHE344B, PHE393B, PHE399B, PHE421G, PHE463G, PHE501B, PHE534B, PHE535B, PHE543B, PHE577G, PHE629B, PHE629G, PHE638B, PRO279B, PRO352B, PRO374B, PRO400B, PRO420G, PRO437G, PRO468G, PRO475G, PRO480G, PRO482B, PRO482G, PRO520B, PRO536B, PRO571G, PRO591G, PRO603B, PRO603G, PRO617B, PRO623B, PRO631B, PRO633B, PRO697G, PRO735G, SER261B, SER262B, SER268B, SER277B, SER357B, SER385B, SER391B, SER392B, SER423G, SER424G, SER428G, SER430G, SER464G, SER467G, SER472G, SER490B, SER499B, SER507B, SER516B, SER538B, SER547B, SER551B, SER586G, SER587G, SER588G, SER632B, SER632G, SER692G, THR265B, THR278B, THR380B, THR449G, THR492B, THR494B, THR502B, THR504B, THR522B, THR553B, THR561B, THR569G, THR574B, THR574G, THR579G, THR589G, THR593G, THR625B, THR729G, THR733G, TRP280B, TRP305G, TRP478G, TRP503B, TRP607B, TRP607G, TRP619B, TRP695G, TYR252B, TYR273B, TYR276B, TYR282B, TYR349B, TYR353B, TYR376B, TYR378B, TYR394B, TYR398B, TYR425G, TYR442G, TYR444G, TYR445G, TYR484B, TYR509B, TYR613B, TYR701G, TYR731G, VAL354B, VAL388B, VAL473G, VAL489B, VAL540B, VAL558B, VAL572B, VAL572G, VAL580G, VAL582G, VAL596B, VAL596G, VAL598B, VAL598G, VAL606G, VAL699G
• B-H: ALA664B, ARG465H, ASN436H, ASP440H, GLU661B, ILE439H, LEU438H, PHE662B, SER663B, THR665B, TYR442H
• B-N: ALA224N, ALA387B, ALA709N, ARG245N, ARG405B, ASN227N, ASN408B, ASP369N, ASP716N, GLN259B, GLN320N, GLU397B, GLY222N, GLY407B, LYS258B, LYS666B, MET403B, SER401B, SER708N, THR338B, THR406N, TRP228N, VAL221N
• C-E: ALA224C, ALA248C, ALA263E, ALA334C, ALA334E, ALA368C, ALA387E, ALA656E, ALA660E, ALA664E, ALA668E, ALA706C, ALA709C, ARG245C, ARG295C, ARG299C, ARG390E, ARG405C, ARG405E, ASN223C, ASN223E, ASN227C, ASN253C, ASN253E, ASN254C, ASN318C, ASN327E, ASN335C, ASN335E, ASN336C, ASN336E, ASN382E, ASN383E, ASN408C, ASN408E, ASN409E, ASN651C, ASN657E, ASN704C, ASN710C, ASN717C, ASN718C, ASP231C, ASP296C, ASP328C, ASP328E, ASP369C, ASP712C, ASP716C, CYS230C, CYS362C, CYS395E, GLN259E, GLN320C, GLN342E, GLN350E, GLN360C, GLN375C, GLN386E, GLN402E, GLN673C, GLN673E, GLN678C, GLU323C, GLU323E, GLU348E, GLU397E, GLU546C, GLU661E, GLY222C, GLY222E, GLY226C, GLY275E, GLY329C, GLY361C, GLY384E, GLY389E, GLY407C, GLY407E, GLY677C, GLY719C, HIS229C, HIS255E, HIS291C, HIS359C, ILE240C, ILE260E, ILE319C, ILE333C, ILE373C, ILE671E, LEU249C, LEU256E, LEU337C, LEU337E, LEU381E, LEU396E, LEU404E, LEU720C, LYS258E, LYS322C, LYS650E, LYS666E, LYS707C, MET372C, MET403E, PHE274E, PHE292C, PHE317C, PHE344E, PHE366C, PHE371C, PHE393E, PHE399E, PHE662E, PHE667E, PHE670E, PHE713C, PRO250C, PRO279E, PRO294C, PRO364C, PRO367C, PRO374C, PRO400E, PRO653E, PRO655E, PRO658E, PRO659E, SER225C, SER232C, SER243C, SER261E, SER277E, SER293C, SER339E, SER385E, SER391E, SER392E, SER401E, SER663E, SER669E, SER675C, SER703C, SER708C, THR233C, THR241C, THR242C, THR244C, THR246C, THR251C, THR278E, THR325C, THR325E, THR326C, THR326E, THR331C, THR332C, THR332E, THR338E, THR340E, THR380E, THR406C, THR406E, THR652E, THR665E, THR672C, THR672E, THR676C, THR702C, THR714C, TRP228C, TRP234C, TRP247C, TRP280E, TRP297C, TYR252C, TYR257E, TYR276E, TYR282C, TYR376C, TYR378E, TYR394E, TYR398E, TYR674C, TYR705C, TYR721C, VAL221C, VAL221E, VAL321C, VAL321E, VAL324C, VAL330C, VAL341E, VAL343E, VAL370C, VAL388E, VAL654E, VAL679C, VAL711C, VAL715C
• C-G: ALA664C, ARG465G, ASN436G, ASP440G, GLU661C, ILE439G, LEU438G, PHE662C, SER663C, THR665C, TYR442G
• D-E: ALA267D, ALA358D, ALA426E, ALA456E, ALA469E, ALA506D, ALA523D, ALA523E, ALA525E, ALA548D, ALA550D, ALA554D, ALA568E, ALA573D, ALA581E, ALA592E, ALA601D, ALA601E, ALA620D, ARG287D, ARG390D, ARG433E, ARG448E, ARG465E, ARG485D, ARG488D, ARG514D, ARG576D, ARG576E, ARG610D, ARG610E, ARG694E, ARG730E, ARG734E, ASN253D, ASN269D, ASN271D, ASN286D, ASN382D, ASN383D, ASN436E, ASN447E, ASN451E, ASN458E, ASN477E, ASN496D, ASN497D, ASN498D, ASN500D, ASN510D, ASN512D, ASN519D, ASN552D, ASN557D, ASN570D, ASN570E, ASN583E, ASN691E, ASN696E, ASP270D, ASP284D, ASP346D, ASP432E, ASP440E, ASP460E, ASP495D, ASP529E, ASP530E, ASP556D, ASP590E, ASP595D, ASP595E, ASP609D, ASP609E, ASP611E, ASP626D, CYS362D, CYS395D, CYS483D, CYS483E, GLN350D, GLN360D, GLN375D, GLN386D, GLN429E, GLN441E, GLN450E, GLN452E, GLN457E, GLN474E, GLN486D, GLN487D, GLN585E, GLN608D, GLN608E, GLN615D, GLN646D, GLN688E, GLN700E, GLU348D, GLU397D, GLU515D, GLU546D, GLU564E, GLU565E, GLU575D, GLU575E, GLU698E, GLY266D, GLY275D, GLY281D, GLY356D, GLY361D, GLY377D, GLY384D, GLY389D, GLY466E, GLY470E, GLY481D, GLY481E, GLY505D, GLY513D, GLY521D, GLY539D, GLY544D, GLY549D, GLY578E, GLY594E, GLY600D, GLY600E, GLY604E, GLY616D, GLY627D, GLY627E, GLY636D, GLY637D, GLY639D, GLY728E, HIS272D, HIS289D, HIS359D, HIS422E, HIS427E, HIS527E, HIS597D, HIS597E, HIS624D, HIS628D, HIS628E, HIS630D, HIS630E, ILE260D, ILE301E, ILE373D, ILE439E, ILE517D, ILE518D, ILE542D, ILE560D, ILE566E, ILE618D, ILE622D, LEU351D, LEU355D, LEU379D, LEU381D, LEU396D, LEU431E, LEU434E, LEU438E, LEU443E, LEU446E, LEU461E, LEU462E, LEU479E, LEU511D, LEU555D, LEU584E, LEU602D, LEU602E, LEU634D, LEU640D, LEU648D, LEU732E, LEU736E, LYS258D, LYS459E, LYS476E, LYS491D, LYS493D, LYS508D, LYS528D, LYS528E, LYS531D, LYS531E, LYS533D, LYS545D, LYS567E, LYS621D, LYS693E, MET435E, MET471E, MET524D, MET537D, MET541D, MET559D, MET599D, MET599E, MET605D, MET605E, MET635D, PHE274D, PHE288D, PHE344D, PHE393D, PHE399D, PHE421E, PHE463E, PHE501D, PHE534D, PHE535D, PHE543D, PHE577E, PHE629D, PHE629E, PHE638D, PRO279D, PRO352D, PRO374D, PRO400D, PRO420E, PRO437E, PRO468E, PRO475E, PRO480E, PRO482D, PRO482E, PRO520D, PRO536D, PRO571E, PRO591E, PRO603D, PRO603E, PRO617D, PRO623D, PRO631D, PRO633D, PRO697E, PRO735E, SER261D, SER262D, SER268D, SER277D, SER357D, SER385D, SER391D, SER392D, SER423E, SER424E, SER428E, SER430E, SER464E, SER467E, SER472E, SER490D, SER499D, SER507D, SER516D, SER538D, SER547D, SER551D, SER586E, SER587E, SER588E, SER632D, SER632E, SER692E, THR265D, THR278D, THR380D, THR449E, THR492D, THR494D, THR502D, THR504D, THR522D, THR553D, THR561D, THR569E, THR574D, THR574E, THR579E, THR589E, THR593E, THR625D, THR729E, THR733E, TRP280D, TRP305E, TRP478E, TRP503D, TRP607D, TRP607E, TRP619D, TRP695E, TYR252D, TYR273D, TYR276D, TYR282D, TYR349D, TYR353D, TYR376D, TYR378D, TYR394D, TYR398D, TYR425E, TYR442E, TYR444E, TYR445E, TYR484D, TYR509D, TYR613D, TYR701E, TYR731E, VAL354D, VAL388D, VAL473E, VAL489D, VAL540D, VAL558D, VAL572D, VAL572E, VAL580E, VAL582E, VAL596D, VAL596E, VAL598D, VAL598E, VAL606E, VAL699E
• D-F: ALA664D, ARG465F, ASN436F, ASP440F, GLU661D, ILE439F, LEU438F, PHE662D, SER663D, THR665D, TYR442F
• D-I: ALA224I, ALA248I, ALA263D, ALA334D, ALA334I, ALA368I, ALA387D, ALA656D, ALA660D, ALA664D, ALA668D, ALA706I, ALA709I, ARG245I, ARG295I, ARG299I, ARG390D, ARG405D, ARG405I, ASN223D, ASN223I, ASN227I, ASN253D, ASN253I, ASN254I, ASN318I, ASN327D, ASN335D, ASN335I, ASN336D, ASN336I, ASN382D, ASN383D, ASN408D, ASN408I, ASN409D, ASN651I, ASN657D, ASN704I, ASN710I, ASN717I, ASN718I, ASP231I, ASP296I, ASP328D, ASP328I, ASP369I, ASP712I, ASP716I, CYS230I, CYS362I, CYS395D, GLN259D, GLN320I, GLN342D, GLN350D, GLN360I, GLN375I, GLN386D, GLN402D, GLN673D, GLN673I, GLN678I, GLU323D, GLU323I, GLU348D, GLU397D, GLU546I, GLU661D, GLY222D, GLY222I, GLY226I, GLY275D, GLY329I, GLY361I, GLY384D, GLY389D, GLY407D, GLY407I, GLY677I, GLY719I, HIS229I, HIS255D, HIS291I, HIS359I, ILE240I, ILE260D, ILE319D, ILE319I, ILE333I, ILE373I, ILE671D, LEU249I, LEU256D, LEU337D, LEU337I, LEU381D, LEU396D, LEU404D, LEU720I, LYS258D, LYS322I, LYS650D, LYS666D, LYS707I, MET372I, MET403D, PHE274D, PHE292I, PHE317I, PHE344D, PHE366I, PHE371I, PHE393D, PHE399D, PHE662D, PHE667D, PHE670D, PHE713I, PRO250I, PRO279D, PRO294I, PRO364I, PRO367I, PRO374I, PRO400D, PRO653D, PRO655D, PRO658D, PRO659D, SER225D, SER225I, SER232I, SER243I, SER261D, SER264D, SER277D, SER293I, SER339D, SER385D, SER391D, SER392D, SER401D, SER663D, SER669D, SER675I, SER703I, SER708I, THR233I, THR241I, THR242I, THR244I, THR246I, THR251I, THR278D, THR325D, THR325I, THR326D, THR326I, THR331I, THR332D, THR332I, THR338D, THR340D, THR380D, THR406D, THR406I, THR652D, THR665D, THR672D, THR672I, THR676I, THR702I, THR714I, TRP228I, TRP234I, TRP247I, TRP280D, TYR252I, TYR257D, TYR276D, TYR282I, TYR376I, TYR378D, TYR394D, TYR398D, TYR674I, TYR705I, TYR721I, VAL221D, VAL221I, VAL321D, VAL321I, VAL324I, VAL330I, VAL341D, VAL343D, VAL370I, VAL388D, VAL654D, VAL679I, VAL711I, VAL715I
• D-J: ARG405J, GLY222D, LEU337D, LEU337J, THR338J, VAL221D, VAL221J
• D-L: ALA224D, ALA248D, ALA263L, ALA334D, ALA334L, ALA368D, ALA387L, ALA656L, ALA660L, ALA664L, ALA668L, ALA706D, ALA709D, ARG245D, ARG295D, ARG299D, ARG390L, ARG405D, ARG405L, ASN223D, ASN223L, ASN227D, ASN253D, ASN253L, ASN254D, ASN318D, ASN327L, ASN335D, ASN335L, ASN336D, ASN336L, ASN382L, ASN383L, ASN408D, ASN408L, ASN409L, ASN651D, ASN657L, ASN704D, ASN710D, ASN717D, ASN718D, ASP231D, ASP296D, ASP328D, ASP328L, ASP369D, ASP712D, ASP716D, CYS230D, CYS362D, CYS395L, GLN259L, GLN320D, GLN342L, GLN350L, GLN360D, GLN375D, GLN386L, GLN402L, GLN673D, GLN673L, GLN678D, GLU323D, GLU323L, GLU348L, GLU397L, GLU546D, GLU661L, GLY222D, GLY222L, GLY226D, GLY275L, GLY329D, GLY361D, GLY384L, GLY389L, GLY407D, GLY407L, GLY677D, GLY719D, HIS229D, HIS255L, HIS291D, HIS359D, ILE240D, ILE260L, ILE319D, ILE319L, ILE333D, ILE373D, ILE671L, LEU249D, LEU256L, LEU337D, LEU337L, LEU381L, LEU396L, LEU404L, LEU720D, LYS258L, LYS322D, LYS650L, LYS666L, LYS707D, MET372D, MET403L, PHE274L, PHE292D, PHE317D, PHE344L, PHE366D, PHE371D, PHE393L, PHE399L, PHE662L, PHE667L, PHE670L, PHE713D, PRO250D, PRO279L, PRO294D, PRO364D, PRO367D, PRO374D, PRO400L, PRO653L, PRO655L, PRO658L, PRO659L, SER225D, SER232D, SER243D, SER261L, SER277L, SER293D, SER339L, SER385L, SER391L, SER392L, SER401L, SER663L, SER669L, SER675D, SER703D, SER708D, THR233D, THR241D, THR242D, THR244D, THR246D, THR251D, THR278L, THR325D, THR325L, THR326D, THR326L, THR331D, THR332D, THR332L, THR338L, THR340L, THR380L, THR406D, THR406L, THR652L, THR665L, THR672D, THR672L, THR676D, THR702D, THR714D, TRP228D, TRP234D, TRP247D, TRP280L, TRP297D, TYR252D, TYR257L, TYR276L, TYR282D, TYR378L, TYR394L, TYR398L, TYR674D, TYR705D, TYR721D, VAL221D, VAL221L, VAL321D, VAL321L, VAL324D, VAL330D, VAL341L, VAL343L, VAL370D, VAL388L, VAL654L, VAL679D, VAL711D, VAL715D
• E-I: ALA368E, ALA368I, ALA706E, ALA706I, ARG245E, ARG245I, ARG295E, ARG295I, ARG299E, ARG299I, ARG694E, ARG694I, ARG725E, ARG725I, ASN302E, ASN302I, ASN303E, ASN303I, ASN304E, ASN304I, ASN691E, ASN691I, ASN696E, ASN696I, ASN704E, ASN704I, ASP231E, ASP231I, ASP296E, ASP296I, ASP529E, ASP529I, ASP530E, ASP530I, ASP532E, ASP532I, ASP562I, ASP712E, ASP712I, CYS230E, CYS230I, CYS290E, CYS290I, GLN298E, GLN298I, GLN700E, GLN700I, GLU564E, GLU564I, GLU565E, GLU565I, GLU690E, GLU690I, GLU698E, GLU698I, GLU723E, GLU723I, GLY236E, GLY236I, HIS289E, HIS289I, HIS291E, HIS291I, HIS527E, HIS527I, ILE727E, ILE727I, LEU614E, LEU614I, LEU732E, LEU732I, LYS531I, LYS689E, LYS689I, LYS693E, LYS693I, LYS707E, LYS707I, PHE292E, PHE292I, PHE366E, PHE366I, PHE713E, PHE713I, PRO294E, PRO294I, PRO364E, PRO364I, PRO365E, PRO365I, PRO367E, PRO367I, PRO697E, PRO697I, PRO724E, PRO724I, SER232E, SER232I, SER243E, SER243I, SER293E, SER293I, SER692E, SER692I, SER703E, SER703I, THR233E, THR233I, THR702E, THR702I, THR714E, THR714I, THR733E, THR733I, TRP234E, TRP234I, TRP297E, TRP297I, TRP305E, TRP305I, TRP695E, TRP695I, TYR701E, TYR701I, TYR705E, TYR705I, TYR721E, TYR721I, TYR731E, TYR731I, VAL699E, VAL699I, VAL711E, VAL711I, VAL715E, VAL715I
• E-L: ALA664L, ARG465E, ASN436E, ASP440E, GLU661L, ILE439E, LEU438E, PHE662L, SER663L, THR665L, TYR442E
• E-P: ALA224E, ALA387P, ALA709E, ARG245E, ARG405P, ASN227E, ASN335E, ASN408P, ASP296E, ASP369E, ASP716E, GLN259P, GLU397P, GLY222E, GLY407P, LYS258P, LYS666P, MET403P, SER401P, SER708E, THR338P, THR406E, TRP228E, TYR398P, VAL221E
• F-H: ALA224H, ALA248H, ALA263F, ALA334F, ALA334H, ALA368H, ALA387F, ALA656F, ALA660F, ALA664F, ALA668F, ALA706H, ALA709H, ARG245H, ARG295H, ARG299H, ARG390F, ARG405F, ARG405H, ASN223F, ASN223H, ASN227H, ASN253F, ASN253H, ASN254H, ASN318H, ASN327F, ASN335F, ASN335H, ASN336F, ASN336H, ASN382F, ASN383F, ASN408F, ASN408H, ASN409F, ASN651H, ASN657F, ASN704H, ASN710H, ASN717H, ASN718H, ASP231H, ASP296H, ASP328F, ASP328H, ASP369H, ASP712H, ASP716H, CYS230H, CYS362H, CYS395F, GLN259F, GLN320H, GLN342F, GLN350F, GLN360H, GLN375H, GLN386F, GLN402F, GLN673F, GLN673H, GLN678H, GLU323F, GLU323H, GLU348F, GLU397F, GLU546H, GLU661F, GLY222F, GLY222H, GLY226H, GLY275F, GLY329H, GLY361H, GLY384F, GLY389F, GLY407F, GLY407H, GLY677H, GLY719H, HIS229H, HIS255F, HIS291H, HIS359H, ILE240H, ILE260F, ILE319H, ILE333H, ILE373H, ILE671F, LEU249H, LEU256F, LEU337F, LEU337H, LEU381F, LEU396F, LEU404F, LEU720H, LYS258F, LYS322H, LYS650F, LYS666F, LYS707H, MET372H, MET403F, PHE274F, PHE292H, PHE317H, PHE344F, PHE366H, PHE371H, PHE393F, PHE399F, PHE662F, PHE667F, PHE670F, PHE713H, PRO250H, PRO279F, PRO294H, PRO364H, PRO367H, PRO374H, PRO400F, PRO653F, PRO655F, PRO658F, PRO659F, SER225H, SER232H, SER243H, SER261F, SER277F, SER293H, SER339F, SER385F, SER391F, SER392F, SER401F, SER663F, SER669F, SER675H, SER703H, SER708H, THR233H, THR241H, THR242H, THR244H, THR246H, THR251H, THR278F, THR325F, THR325H, THR326F, THR326H, THR331H, THR332F, THR332H, THR338F, THR340F, THR380F, THR406F, THR406H, THR652F, THR665F, THR672F, THR672H, THR676H, THR702H, THR714H, TRP228H, TRP234H, TRP247H, TRP280F, TRP297H, TYR252H, TYR257F, TYR276F, TYR282H, TYR376H, TYR378F, TYR394F, TYR398F, TYR674H, TYR705H, TYR721H, VAL221F, VAL221H, VAL321F, VAL321H, VAL324H, VAL330H, VAL341F, VAL343F, VAL370H, VAL388F, VAL654F, VAL679H, VAL711H, VAL715H
• F-I: ALA267I, ALA358I, ALA426F, ALA456F, ALA469F, ALA506I, ALA523F, ALA523I, ALA525F, ALA548I, ALA550I, ALA554I, ALA568F, ALA573I, ALA581F, ALA592F, ALA601F, ALA601I, ALA620I, ARG287I, ARG390I, ARG433F, ARG448F, ARG465F, ARG485I, ARG488I, ARG514I, ARG576F, ARG576I, ARG610F, ARG610I, ARG694F, ARG730F, ARG734F, ASN253I, ASN269I, ASN271I, ASN286I, ASN382I, ASN383I, ASN436F, ASN447F, ASN451F, ASN458F, ASN477F, ASN496I, ASN497I, ASN498I, ASN500I, ASN510I, ASN512I, ASN519I, ASN552I, ASN557I, ASN570F, ASN570I, ASN583F, ASN691F, ASN696F, ASP270I, ASP284I, ASP346I, ASP432F, ASP440F, ASP460F, ASP495I, ASP529F, ASP530F, ASP556I, ASP590F, ASP595F, ASP595I, ASP609F, ASP609I, ASP611F, ASP626I, CYS362I, CYS395I, CYS483F, CYS483I, GLN350I, GLN360I, GLN375I, GLN386I, GLN429F, GLN441F, GLN450F, GLN452F, GLN457F, GLN474F, GLN486I, GLN487I, GLN585F, GLN608F, GLN608I, GLN615I, GLN646I, GLN688F, GLN700F, GLU348I, GLU397I, GLU515I, GLU546I, GLU564F, GLU565F, GLU575F, GLU575I, GLU698F, GLY266I, GLY275I, GLY281I, GLY356I, GLY361I, GLY377I, GLY384I, GLY389I, GLY466F, GLY470F, GLY481F, GLY481I, GLY505I, GLY513I, GLY521I, GLY539I, GLY544I, GLY549I, GLY578F, GLY594F, GLY600F, GLY600I, GLY604F, GLY616I, GLY627F, GLY627I, GLY636I, GLY637I, GLY639I, GLY728F, HIS272I, HIS289I, HIS359I, HIS422F, HIS427F, HIS527F, HIS597F, HIS597I, HIS624I, HIS628F, HIS628I, HIS630F, HIS630I, ILE260I, ILE301F, ILE373I, ILE439F, ILE517I, ILE518I, ILE542I, ILE560I, ILE566F, ILE618I, ILE622I, LEU351I, LEU355I, LEU379I, LEU381I, LEU396I, LEU431F, LEU434F, LEU438F, LEU443F, LEU446F, LEU461F, LEU462F, LEU479F, LEU511I, LEU555I, LEU584F, LEU602F, LEU602I, LEU634I, LEU640I, LEU648I, LEU732F, LEU736F, LYS258I, LYS459F, LYS476F, LYS491I, LYS493I, LYS508I, LYS528F, LYS528I, LYS531F, LYS531I, LYS533I, LYS545I, LYS567F, LYS621I, LYS693F, MET372I, MET435F, MET471F, MET524I, MET537I, MET541I, MET559I, MET599F, MET599I, MET605F, MET605I, MET635I, PHE274I, PHE288I, PHE344I, PHE393I, PHE399I, PHE421F, PHE463F, PHE501I, PHE534I, PHE535I, PHE543I, PHE577F, PHE629F, PHE629I, PHE638I, PRO279I, PRO352I, PRO374I, PRO400I, PRO420F, PRO437F, PRO468F, PRO475F, PRO480F, PRO482F, PRO482I, PRO520I, PRO536I, PRO571F, PRO591F, PRO603F, PRO603I, PRO617I, PRO623I, PRO631I, PRO633I, PRO697F, PRO735F, SER261I, SER262I, SER268I, SER277I, SER357I, SER385I, SER391I, SER392I, SER423F, SER424F, SER428F, SER430F, SER464F, SER467F, SER472F, SER490I, SER499I, SER507I, SER516I, SER538I, SER547I, SER551I, SER586F, SER587F, SER588F, SER632F, SER632I, SER692F, THR265I, THR278I, THR380I, THR449F, THR492I, THR494I, THR502I, THR504I, THR522I, THR553I, THR561I, THR569F, THR574F, THR574I, THR579F, THR589F, THR593F, THR625I, THR729F, THR733F, TRP280I, TRP305F, TRP478F, TRP503I, TRP607F, TRP607I, TRP619I, TRP695F, TYR252I, TYR273I, TYR276I, TYR282I, TYR349I, TYR353I, TYR376I, TYR378I, TYR394I, TYR398I, TYR425F, TYR442F, TYR444F, TYR445F, TYR484I, TYR509I, TYR613I, TYR701F, TYR731F, VAL354I, VAL388I, VAL473F, VAL489I, VAL540I, VAL558I, VAL572F, VAL572I, VAL580F, VAL582F, VAL596F, VAL596I, VAL598F, VAL598I, VAL606F, VAL699F
• F-K: ALA224F, ALA248F, ALA263K, ALA334F, ALA334K, ALA368F, ALA387K, ALA656K, ALA660K, ALA664K, ALA668K, ALA706F, ALA709F, ARG245F, ARG295F, ARG299F, ARG390K, ARG405F, ARG405K, ASN223F, ASN223K, ASN227F, ASN253F, ASN253K, ASN254F, ASN318F, ASN327K, ASN335F, ASN335K, ASN336F, ASN336K, ASN382K, ASN383K, ASN408F, ASN408K, ASN409K, ASN651F, ASN657K, ASN704F, ASN710F, ASN717F, ASN718F, ASP231F, ASP296F, ASP328F, ASP328K, ASP369F, ASP712F, ASP716F, CYS230F, CYS362F, CYS395K, GLN259K, GLN320F, GLN342K, GLN350K, GLN360F, GLN375F, GLN386K, GLN402K, GLN673F, GLN673K, GLN678F, GLU323F, GLU323K, GLU348K, GLU397K, GLU546F, GLU661K, GLY222F, GLY222K, GLY226F, GLY275K, GLY329F, GLY361F, GLY384K, GLY389K, GLY407F, GLY407K, GLY677F, GLY719F, HIS229F, HIS255K, HIS291F, HIS359F, ILE240F, ILE260K, ILE319F, ILE319K, ILE333F, ILE373F, ILE671K, LEU249F, LEU256K, LEU337F, LEU337K, LEU381K, LEU396K, LEU404K, LEU720F, LYS258K, LYS322F, LYS650K, LYS666K, LYS707F, MET372F, MET403K, PHE274K, PHE292F, PHE317F, PHE344K, PHE366F, PHE371F, PHE393K, PHE399K, PHE662K, PHE667K, PHE670K, PHE713F, PRO250F, PRO279K, PRO294F, PRO364F, PRO367F, PRO374F, PRO400K, PRO653K, PRO655K, PRO658K, PRO659K, SER225F, SER232F, SER243F, SER261K, SER277K, SER293F, SER339K, SER385K, SER391K, SER392K, SER401K, SER663K, SER669K, SER675F, SER703F, SER708F, THR233F, THR241F, THR242F, THR244F, THR246F, THR251F, THR278K, THR325F, THR325K, THR326F, THR326K, THR331F, THR332F, THR332K, THR338K, THR340K, THR380K, THR406F, THR406K, THR652K, THR665K, THR672F, THR672K, THR676F, THR702F, THR714F, TRP228F, TRP234F, TRP247F, TRP280K, TRP297F, TYR252F, TYR257K, TYR276K, TYR282F, TYR376F, TYR378K, TYR394K, TYR398K, TYR674F, TYR705F, TYR721F, VAL221F, VAL221K, VAL321F, VAL321K, VAL324F, VAL330F, VAL341K, VAL343K, VAL370F, VAL388K, VAL654K, VAL679F, VAL711F, VAL715F
• F-P: ALA550F, ARG390F, ARG433P, ARG465P, ARG514F, ARG576P, ARG694P, ARG730P, ARG734P, ASN271F, ASN436P, ASN477P, ASN496F, ASN497F, ASN500F, ASN510F, ASN552F, ASP270F, ASP346F, ASP432P, ASP440P, ASP460P, ASP495F, ASP529P, ASP609P, ASP626F, GLN375F, GLN450P, GLN608P, GLU348F, GLU515F, GLU564P, GLU565P, GLU575P, GLU698P, GLY356F, GLY604P, HIS272F, HIS359F, HIS422P, HIS427P, HIS624F, HIS628F, HIS630P, ILE517F, ILE542F, LEU381F, LEU634F, LYS459P, LYS493F, LYS508F, LYS693P, MET635F, PHE393F, PHE463P, PHE577P, PHE629F, SER391F, SER423P, SER428P, SER472P, SER588P, THR449P, THR553F, THR579P, TRP695P, TYR444P, TYR484F
• F-R: ARG295F, ARG295R, ARG299F, ARG299R, ARG694F, ARG694R, ASN303F, ASN303R, ASP231F, ASP231R, ASP529F, ASP529R, ASP530F, ASP530R, GLN700F, GLU690F, GLU690R, GLU698F, GLU698R, LYS693F, LYS693R, LYS707F, LYS707R, SER692F, SER692R, THR702R
• G-M: ARG405G, GLY222M, LEU337G, LEU337M, THR338G, VAL221G, VAL221M
• G-N: ARG295G, ARG295N, ARG299G, ARG299N, ARG694G, ARG694N, ASN303G, ASN303N, ASP231G, ASP231N, ASP529G, ASP529N, ASP530G, ASP530N, GLN700G, GLU690G, GLU690N, GLU698G, GLU698N, LYS693G, LYS693N, LYS707G, LYS707N, SER692G, SER692N, THR702N
• G-Q: ALA224G, ALA387Q, ALA709G, ARG245G, ARG405Q, ASN227G, ASN335G, ASN408Q, ASP296G, ASP369G, ASP716G, GLN259Q, GLU397Q, GLY222G, GLY407Q, LYS258Q, LYS666Q, MET403Q, SER401Q, SER708G, THR338Q, THR406G, TRP228G, TYR398Q, VAL221G
• H-K: ARG405K, GLY222H, LEU337H, LEU337K, THR338K, VAL221H, VAL221K
• H-N: ALA550N, ARG390N, ARG433H, ARG465H, ARG514N, ARG576H, ARG694H, ARG730H, ARG734H, ASN271N, ASN436H, ASN477H, ASN496N, ASN497N, ASN500N, ASN510N, ASN691H, ASP270N, ASP346N, ASP432H, ASP440H, ASP460H, ASP495N, ASP529H, ASP609H, ASP626N, GLN375N, GLN450H, GLN608H, GLU348N, GLU515N, GLU564H, GLU565H, GLU575H, GLU698H, GLY356N, GLY549N, GLY604H, GLY627N, HIS272N, HIS359N, HIS422H, HIS427H, HIS624N, HIS628N, HIS630H, ILE517N, ILE542N, LEU381N, LEU634N, LYS459H, LYS493N, LYS508N, LYS693H, MET635N, PHE393N, PHE463H, PHE577H, PHE629N, SER391N, SER392N, SER428H, SER472H, SER588H, THR449H, THR553N, THR579H, TRP607H, TRP695H, TYR444H
• H-O: ALA224O, ALA387H, ALA709O, ARG245O, ARG405H, ASN227O, ASN408H, ASP369O, ASP716O, GLN259H, GLU397H, GLY222O, GLY407H, LYS258H, LYS666H, MET403H, SER401H, SER708O, THR406O, TRP228O, VAL221O
• H-P: ARG295H, ARG295P, ARG299H, ARG299P, ARG694H, ARG694P, ASN303H, ASN303P, ASP231H, ASP231P, ASP529H, ASP529P, ASP530H, ASP530P, GLN700H, GLU690H, GLU690P, GLU698H, GLU698P, LYS693H, LYS693P, LYS707H, LYS707P, THR702P
• H-Q: ALA550H, ARG390H, ARG433Q, ARG465Q, ARG514H, ARG576Q, ARG694Q, ARG730Q, ARG734Q, ASN271H, ASN436Q, ASN477Q, ASN496H, ASN497H, ASN500H, ASN510H, ASP270H, ASP346H, ASP432Q, ASP440Q, ASP460Q, ASP495H, ASP529Q, ASP609Q, ASP626H, GLN375H, GLN450Q, GLN608Q, GLU348H, GLU515H, GLU564Q, GLU565Q, GLU575Q, GLU698Q, GLY356H, GLY604Q, HIS272H, HIS359H, HIS422Q, HIS427Q, HIS624H, HIS628H, HIS630Q, ILE517H, ILE542H, LEU381H, LEU634H, LYS459Q, LYS493H, LYS508H, LYS693Q, MET635H, PHE393H, PHE463Q, PHE577Q, PHE629H, SER391H, SER428Q, SER472Q, SER588Q, THR380H, THR449Q, THR553H, THR579Q, TRP695Q, TYR444Q
• I-J: ARG405I, GLY222J, LEU337I, LEU337J, THR338I, VAL221I, VAL221J
• I-L: ARG405L, GLY222I, LEU337I, LEU337L, THR338L, VAL221I, VAL221L
• I-P: ALA550P, ARG390P, ARG433I, ARG465I, ARG514P, ARG576I, ARG694I, ARG730I, ARG734I, ASN271P, ASN436I, ASN477I, ASN496P, ASN497P, ASN500P, ASN510P, ASP270P, ASP346P, ASP432I, ASP440I, ASP460I, ASP495P, ASP529I, ASP609I, ASP626P, GLN375P, GLN450I, GLN608I, GLU348P, GLU515P, GLU564I, GLU565I, GLU575I, GLU698I, GLY356P, GLY549P, GLY604I, HIS272P, HIS359P, HIS422I, HIS427I, HIS624P, HIS628P, HIS630I, ILE517P, ILE542P, LEU381P, LEU634P, LYS459I, LYS493P, LYS508P, LYS693I, MET635P, PHE393P, PHE463I, PHE577I, PHE629P, SER391P, SER392P, SER428I, SER472I, SER588I, THR449I, THR553P, THR579I, TRP695I, TYR444I, TYR484P
• I-R: ALA224R, ALA387I, ALA709R, ARG245R, ARG405I, ASN227R, ASN336I, ASN408I, ASP369R, ASP716R, GLN259I, GLU397I, GLY222R, GLY407I, LYS258I, LYS322R, LYS666I, MET403I, PRO655I, SER401I, SER708R, THR406R, TRP228R, TYR674R, VAL221R
• J-L: ALA224L, ALA248L, ALA263J, ALA334J, ALA334L, ALA368L, ALA387J, ALA548L, ALA656J, ALA660J, ALA664J, ALA668J, ALA706L, ALA709L, ARG245L, ARG295L, ARG299L, ARG390J, ARG405J, ARG405L, ASN223J, ASN223L, ASN227L, ASN253J, ASN253L, ASN254J, ASN254L, ASN318L, ASN327J, ASN335J, ASN335L, ASN336J, ASN336L, ASN382J, ASN383J, ASN408J, ASN408L, ASN409J, ASN409L, ASN651L, ASN657J, ASN704L, ASN710L, ASN717L, ASN718L, ASP231L, ASP296L, ASP328J, ASP328L, ASP369L, ASP712L, ASP716L, CYS230L, CYS290L, CYS362L, CYS395J, GLN259J, GLN320L, GLN342J, GLN350J, GLN360L, GLN375L, GLN386J, GLN402J, GLN673J, GLN673L, GLN678L, GLU323J, GLU323L, GLU348J, GLU397J, GLU546L, GLU661J, GLY222J, GLY222L, GLY226L, GLY275J, GLY329L, GLY361L, GLY384J, GLY389J, GLY407J, GLY407L, GLY677L, GLY719L, HIS229L, HIS255J, HIS291L, HIS359L, ILE240L, ILE260J, ILE319J, ILE319L, ILE333L, ILE373L, ILE671J, LEU249L, LEU256J, LEU337J, LEU337L, LEU381J, LEU396J, LEU404J, LEU720L, LYS258J, LYS258L, LYS322L, LYS650J, LYS666J, LYS707L, MET372L, MET403J, PHE274J, PHE292L, PHE317L, PHE344J, PHE366L, PHE371L, PHE393J, PHE399J, PHE410J, PHE662J, PHE667J, PHE670J, PHE713L, PRO250L, PRO279J, PRO294L, PRO364L, PRO365L, PRO367L, PRO374L, PRO400J, PRO653J, PRO655J, PRO658J, PRO659J, SER225J, SER225L, SER232L, SER243L, SER261J, SER277J, SER293L, SER339J, SER339L, SER385J, SER391J, SER392J, SER401J, SER547L, SER663J, SER669J, SER675L, SER703L, SER708L, THR233L, THR241L, THR242L, THR244L, THR246L, THR251L, THR278J, THR325J, THR325L, THR326J, THR326L, THR331L, THR332J, THR332L, THR338J, THR338L, THR340J, THR380J, THR406J, THR406L, THR652J, THR665J, THR672J, THR672L, THR676L, THR702L, THR714L, THR722L, TRP228L, TRP234L, TRP247L, TRP280J, TRP297L, TYR252L, TYR257J, TYR276J, TYR282L, TYR376L, TYR378J, TYR394J, TYR398J, TYR674L, TYR705L, TYR721L, VAL221J, VAL221L, VAL239L, VAL321J, VAL321L, VAL324L, VAL330J, VAL330L, VAL341J, VAL343J, VAL370L, VAL388J, VAL654J, VAL679L, VAL711L, VAL715L
• J-R: ALA387R, ALA709J, ARG245J, ARG405R, ASP369J, ASP716J, GLN259R, GLN320J, GLU397R, GLY389R, GLY719J, LYS258R, LYS666R, SER401R, SER708J, THR338R, TRP228J, TYR705J, VAL221J
• K-R: ALA550K, ARG390K, ARG433R, ARG465R, ARG514K, ARG576R, ARG694R, ARG730R, ARG734R, ASN271K, ASN436R, ASN477R, ASN496K, ASN497K, ASN500K, ASN510K, ASP270K, ASP346K, ASP432R, ASP440R, ASP460R, ASP495K, ASP529R, ASP609R, ASP626K, GLN375K, GLN450R, GLN608R, GLU348K, GLU515K, GLU564R, GLU565R, GLU575R, GLU698R, GLY356K, GLY604R, HIS272K, HIS359K, HIS422R, HIS427R, HIS624K, HIS628K, HIS630R, ILE517K, ILE542K, LEU381K, LEU634K, LYS459R, LYS493K, LYS508K, LYS693R, MET635K, PHE393K, PHE463R, PHE577R, PHE629K, SER391K, SER423R, SER428R, SER472R, SER588R, THR449R, THR553K, THR579R, TRP695R, TYR444R, TYR484K
• K-S: ALA224K, ALA387S, ALA709K, ARG245K, ARG405S, ASN227K, ASN335K, ASN408S, ASP369K, ASP716K, GLN259S, GLU397S, GLY222K, GLY407S, LYS258S, LYS666S, MET403S, PRO655S, SER401S, SER708K, THR338S, THR406K, TRP228K, TYR674K, VAL221K
• M-T: ALA224T, ALA387M, ALA709T, ARG245T, ARG405M, ASN227T, ASN408M, ASP369T, ASP716T, GLN259M, GLU397M, GLY222T, GLY407M, LYS258M, LYS666M, MET403M, SER401M, SER708T, THR406T, TRP228T, VAL221T
• N-P: ALA224P, ALA387N, ALA709P, ARG245P, ARG405N, ASN408N, ASP369P, ASP716P, GLN259N, GLN320P, GLU397N, GLY222P, GLY407N, GLY719P, LYS258N, LYS666N, PRO655N, SER401N, SER708P, THR338N, THR406P, TRP228P, TYR674P, VAL221P
• N-Q: ALA550Q, ARG390Q, ARG433N, ARG465N, ARG514Q, ARG576N, ARG694N, ARG730N, ARG734N, ASN271Q, ASN436N, ASN477N, ASN496Q, ASN497Q, ASN500Q, ASN510Q, ASP270Q, ASP346Q, ASP432N, ASP440N, ASP460N, ASP495Q, ASP529N, ASP609N, ASP626Q, GLN375Q, GLN450N, GLN608N, GLU348Q, GLU515Q, GLU564N, GLU565N, GLU575N, GLU698N, GLY356Q, GLY604N, HIS272Q, HIS359Q, HIS422N, HIS427N, HIS624Q, HIS628Q, HIS630N, ILE517Q, ILE542Q, LEU381Q, LEU634Q, LYS459N, LYS493Q, LYS508Q, LYS693N, MET635Q, PHE393Q, PHE463N, PHE577N, PHE629Q, SER391Q, SER392Q, SER428N, SER472N, SER588N, THR449N, THR553Q, THR579N, TRP695N, TYR444N, TYR484Q
• O-Q: ARG295O, ARG295Q, ARG299O, ARG299Q, ARG694O, ARG694Q, ASN303O, ASN303Q, ASP231O, ASP231Q, ASP529O, ASP529Q, ASP530O, ASP530Q, GLN700O, GLU690O, GLU690Q, GLU698O, GLU698Q, LYS693O, LYS693Q, LYS707O, LYS707Q, SER692O, SER692Q, THR702Q
• O-S: ALA224S, ALA387O, ALA709S, ARG245S, ARG405O, ASN227S, ASN408O, ASP369S, ASP716S, GLN259O, GLN320S, GLU397O, GLY222S, GLY407O, LYS258O, LYS666O, MET403O, SER401O, SER708S, THR338O, THR406S, TRP228S, VAL221S
• O-T: ALA550T, ARG390T, ARG433O, ARG465O, ARG514T, ARG576O, ARG694O, ARG730O, ARG734O, ASN271T, ASN436O, ASN477O, ASN496T, ASN497T, ASN500T, ASN510T, ASP270T, ASP346T, ASP432O, ASP440O, ASP460O, ASP495T, ASP529O, ASP609O, ASP626T, GLN375T, GLN450O, GLN608O, GLU348T, GLU515T, GLU564O, GLU565O, GLU575O, GLU698O, GLY356T, GLY549T, GLY604O, HIS272T, HIS359T, HIS422O, HIS427O, HIS624T, HIS628T, HIS630O, ILE517T, ILE542T, LEU381T, LEU634T, LYS459O, LYS493T, LYS508T, LYS693O, MET635T, PHE393T, PHE463O, PHE577O, PHE629T, SER391T, SER392T, SER428O, SER472O, SER588O, THR449O, THR553T, THR579O, TRP695O, TYR444O
• Q-T: ALA224Q, ALA387T, ALA709Q, ARG245Q, ARG405T, ASN227Q, ASN335Q, ASN408T, ASP296Q, ASP369Q, ASP716Q, GLN259T, GLU397T, GLY222Q, GLY407T, LYS258T, LYS666T, MET403T, SER401T, SER708Q, THR338T, THR406Q, TRP228Q, TYR398T, VAL221Q