3SDJ

structure of rnase-inactive point mutant of oligomeric kinase/rnase ire1

• Total interactions analyzed: 91
• Total true interactions: 25
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 84
  • Norm. En. per Res.: -4.0359
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-82.0943	-200.9239	-345.532	-628.5503	202	37	4	15931	16	86	80
A-C	-5.0723	-41.8059	-22.0785	-68.9567	51	0	0	1673	3	28	16
A-D	-27.439	-145.0366	-166.542	-339.0176	84	0	0	7245	11	56	36
A-N	0.0	-5.6769	-9.5663	-15.2432	38	0	0	954	1	21	12
B-D	-13.573	-40.3276	-20.3645	-74.2651	49	2	0	1515	4	25	14
B-M	-4.9814	-49.8082	-31.0753	-85.8649	53	5	0	2192	3	32	16
B-N	-23.2401	-131.8822	-144.84	-299.9624	83	1	0	6919	9	57	37
C-D	-39.451	-147.9076	-301.513	-488.8717	195	39	4	14915	18	84	75
C-E	-27.6343	-134.0655	-140.257	-301.9568	83	0	0	6648	8	57	35
C-F	0.0	-2.2249	-3.1355	-5.3604	32	0	0	401	0	13	5
D-E	-2.1868	-46.182	-35.0997	-83.4685	55	0	0	2219	4	31	16
E-F	-93.7338	-213.3942	-318.035	-625.163	203	26	4	15474	17	87	79
E-G	-9.6812	-51.8562	-38.8496	-100.387	55	5	0	2536	3	32	17
F-G	-3.1072	-116.0902	-133.752	-252.9494	81	6	0	6637	9	55	33
F-H	-4.7784	-45.5683	-16.2311	-66.5778	45	1	0	1329	4	25	13
G-H	-106.7135	-204.0354	-364.583	-675.3318	201	36	4	16346	19	89	80
G-I	-7.9463	-50.4916	-35.91	-94.348	51	1	0	2124	4	29	15
H-I	-5.1697	-128.0116	-158.722	-291.9033	87	2	0	7341	9	60	37
H-J	0.0	-38.4395	-26.3825	-64.822	49	1	0	1884	3	26	15
I-J	-73.2819	-167.4393	-307.239	-547.9602	193	22	4	14863	17	79	80
K-L	-75.9094	-161.3166	-304.618	-541.844	195	32	4	15105	18	83	79
K-M	-14.8503	-56.1705	-31.5482	-102.569	56	4	0	2249	5	32	16
L-M	-18.458	-125.9037	-141.756	-286.1177	78	3	0	6674	8	55	32
L-N	0.0	0.0	-2.9234	-2.9234	29	0	0	376	0	11	6
M-N	-89.8017	-181.4851	-342.198	-613.4848	202	33	4	15928	18	88	80

Interface residues

• A-B: ALA1070A, ALA1070B, ALA744A, ALA744B, ALA782A, ALA782B, ALA786A, ALA786B, ALA813A, ALA813B, ALA971B, ARG1053A, ARG1053B, ARG1056A, ARG1056B, ARG1110A, ARG1110B, ARG697A, ARG697B, ARG730A, ARG730B, ARG779A, ARG779B, ARG810A, ARG810B, ARG823A, ARG823B, ARG976A, ARG976B, ARG996A, ARG996B, ASN1061A, ASN1061B, ASN672A, ASN672B, ASN727A, ASN727B, ASP1064A, ASP1064B, ASP1078A, ASP1078B, ASP1106A, ASP1106B, ASP723A, ASP723B, ASP724A, ASP724B, ASP814A, ASP814B, ASP995A, ASP995B, CYS733A, CYS733B, GLN1107A, GLN1107B, GLN695A, GLN695B, GLN780B, GLN815A, GLN815B, GLN816A, GLN816B, GLU1000A, GLU1000B, GLU1071A, GLU1071B, GLU1111A, GLU1111B, GLU721A, GLU721B, GLU735A, GLU735B, GLU746A, GLU746B, GLU988A, GLU988B, GLU998A, GLU998B, GLY1074A, GLY1074B, GLY1079A, GLY1079B, GLY696A, GLY696B, GLY784A, GLY784B, GLY818A, GLY818B, HIS1060A, HIS1060B, HIS725A, HIS725B, HIS787A, HIS787B, HIS789A, HIS789B, ILE1108A, ILE1108B, ILE716A, ILE716B, ILE729A, ILE729B, ILE743A, ILE743B, ILE999A, ILE999B, LEU1065A, LEU1109A, LEU1109B, LEU673A, LEU673B, LEU719A, LEU719B, LEU741A, LEU741B, LEU745A, LEU745B, LEU788A, LEU788B, LEU791A, LEU791B, LEU825A, LEU825B, LEU975A, LEU975B, LEU987A, LEU987B, LEU991A, LEU991B, LEU997A, LEU997B, LYS717A, LYS717B, LYS792A, LYS792B, LYS834A, LYS834B, LYS985A, LYS992A, LYS992B, MET1063A, MET1063B, MET1073A, MET972A, MET972B, PHE1062A, PHE1062B, PHE1080A, PHE1080B, PHE1112A, PHE1112B, PHE694A, PHE694B, PHE811A, PHE811B, PRO1075A, PRO1075B, PRO1077A, PRO1077B, PRO698A, PRO698B, PRO726A, PRO726B, PRO982A, PRO982B, SER1115A, SER1115B, SER722A, SER722B, SER734A, SER734B, SER783A, SER783B, SER790A, SER790B, SER808A, SER809A, SER809B, SER984A, SER984B, THR720A, THR720B, THR736A, THR736B, THR812A, THR812B, THR817A, THR817B, TYR1059A, TYR1059B, TYR731A, TYR731B, TYR732A, TYR732B, TYR742A, TYR742B, VAL1076A, VAL1076B, VAL728A, VAL728B, VAL785A, VAL785B
• A-C: ALA971C, ARG1110C, ARG810A, ARG843C, ARG896C, ARG899C, ARG947A, ARG968C, ARG976C, ASN749A, ASN760A, ASN765A, ASP1105C, ASP763A, GLN1107C, GLN691A, GLN769A, GLN839C, GLU1111C, GLU677A, GLU764A, GLY838C, HIS789C, HIS945A, ILE679A, LEU747A, LEU766A, LEU768A, LEU835C, LEU966C, LYS678A, LYS759A, LYS792C, LYS916A, LYS942A, LYS967C, LYS973C, MET972C, PRO698A, PRO969C, SER1115C, SER676A, SER762A, SER790C, SER808A, SER809A, SER837C, THR898C, THR970C, TYR1114C, VAL761A
• A-D: ALA1070A, ALA1070D, ALA819A, ALA819D, ARG1087A, ARG1087D, ARG947A, ARG947D, ASP1024A, ASP1024D, ASP1030A, ASP1030D, ASP1035A, ASP1035D, ASP1068A, ASP1068D, ASP1082A, ASP1082D, ASP946A, ASP946D, GLN815A, GLN815D, GLU1067A, GLU1067D, GLU1071A, GLU1071D, GLU771A, GLU771D, GLY1074A, GLY1074D, GLY1079A, GLY1079D, HIS945A, HIS945D, ILE1069A, ILE1069D, ILE950A, ILE950D, LEU1072A, LEU1072D, LEU766A, LEU766D, LEU949A, LEU949D, LYS1028A, LYS1028D, LYS1031A, LYS1031D, LYS1086A, LYS1086D, LYS770A, LYS770D, MET1034A, MET1034D, MET1073A, MET1073D, PHE1029A, PHE1029D, PHE1033A, PHE1033D, PHE1084A, PHE1084D, PHE1088A, PHE1088D, PRO1066A, PRO1066D, PRO1075A, PRO1075D, PRO1089A, PRO1089D, SER1022A, SER1022D, SER948A, SER948D, THR1026A, THR1026D, THR1032A, THR1032D, THR1085A, THR1085D, TYR1083A, TYR1083D, VAL1027A, VAL1027D
• A-N: ALA971A, ARG1110A, ARG843A, ARG896A, ARG899A, ARG976A, ASN749N, ASN760N, ASN765N, ASP1105A, ASP763N, GLN1107A, GLN691N, GLN769N, GLN839A, GLU677N, GLY838A, HIS789A, HIS945N, LEU747N, LEU835A, LEU966A, LYS678N, LYS792A, LYS942N, LYS973A, MET972A, PRO698N, PRO969A, SER676N, SER762N, SER790A, SER808N, SER809N, SER837A, THR970A, TYR1114A, VAL761N
• B-D: ALA971B, ARG1110B, ARG810D, ARG843B, ARG896B, ARG899B, ARG968B, ARG976B, ASN749D, ASN760D, ASN765D, ASP1105B, ASP763D, GLN1107B, GLN691D, GLN769D, GLN839B, GLU677D, GLU764D, GLY838B, HIS789B, HIS945D, ILE679D, LEU747D, LEU766D, LEU835B, LEU966B, LYS1100B, LYS678D, LYS759D, LYS792B, LYS942D, LYS967B, LYS973B, MET972B, PRO698D, PRO969B, SER1115B, SER676D, SER762D, SER790B, SER808D, SER809D, SER837B, THR807D, THR898B, THR970B, TYR1114B, VAL761D
• B-M: ALA971M, ARG1110M, ARG810B, ARG843M, ARG896M, ARG899M, ARG947B, ARG968M, ARG976M, ASN749B, ASN760B, ASN765B, ASP1105M, ASP763B, GLN1107M, GLN691B, GLN769B, GLN839M, GLU1111M, GLU677B, GLU764B, GLY838M, HIS789M, HIS945B, ILE679B, LEU680B, LEU747B, LEU766B, LEU768B, LEU835M, LEU966M, LYS678B, LYS759B, LYS792M, LYS916B, LYS942B, LYS967M, LYS973M, MET972M, PRO698B, PRO969M, SER1115M, SER676B, SER762B, SER790M, SER808B, SER809B, SER837M, THR807B, THR898M, THR970M, TYR1114M, VAL761B
• B-N: ALA1070B, ALA1070N, ALA819B, ALA819N, ARG1087B, ARG1087N, ARG947B, ARG947N, ASP1024B, ASP1024N, ASP1030B, ASP1030N, ASP1035B, ASP1035N, ASP1068B, ASP1068N, ASP1082B, ASP1082N, ASP946B, ASP946N, GLN815B, GLN815N, GLU1067B, GLU1067N, GLU1071B, GLU1071N, GLU771B, GLU771N, GLY1074B, GLY1074N, GLY1079B, GLY1079N, HIS945B, HIS945N, ILE1069B, ILE1069N, ILE950B, LEU1072B, LEU1072N, LEU766B, LEU766N, LEU949B, LEU949N, LYS1028B, LYS1028N, LYS1031B, LYS1031N, LYS1086B, LYS1086N, LYS770B, LYS770N, MET1034B, MET1034N, MET1073B, MET1073N, PHE1029B, PHE1029N, PHE1033B, PHE1033N, PHE1084B, PHE1084N, PHE1088B, PHE1088N, PRO1066B, PRO1066N, PRO1075B, PRO1075N, PRO1089B, PRO1089N, SER1022B, SER1022N, SER948B, SER948N, THR1026B, THR1026N, THR1032B, THR1032N, THR1085B, THR1085N, TYR1083B, TYR1083N, VAL1027B, VAL1027N
• C-D: ALA1070C, ALA1070D, ALA744C, ALA744D, ALA782C, ALA782D, ALA786C, ALA786D, ALA813C, ALA813D, ALA971D, ARG1053C, ARG1053D, ARG1056C, ARG1056D, ARG1110C, ARG1110D, ARG697C, ARG697D, ARG730C, ARG730D, ARG779C, ARG779D, ARG810C, ARG810D, ARG823C, ARG823D, ARG976C, ARG976D, ARG996C, ARG996D, ASN1061C, ASN1061D, ASN672C, ASN672D, ASN727C, ASN727D, ASP1064C, ASP1064D, ASP1078C, ASP1078D, ASP1106C, ASP1106D, ASP723C, ASP723D, ASP724C, ASP724D, ASP814C, ASP814D, ASP995C, ASP995D, CYS733C, CYS733D, GLN1107C, GLN1107D, GLN695C, GLN695D, GLN780C, GLN780D, GLN815C, GLN815D, GLN816C, GLN816D, GLU1000C, GLU1000D, GLU1071C, GLU1071D, GLU1111C, GLU1111D, GLU721C, GLU721D, GLU735C, GLU735D, GLU746C, GLU746D, GLU988C, GLU988D, GLU998C, GLU998D, GLY1074C, GLY1074D, GLY696C, GLY696D, GLY784C, GLY784D, GLY818C, GLY818D, HIS1060C, HIS1060D, HIS725C, HIS725D, HIS787C, HIS787D, HIS789D, ILE1108C, ILE1108D, ILE716C, ILE716D, ILE729C, ILE729D, ILE743C, ILE743D, ILE999C, ILE999D, LEU1109D, LEU673C, LEU673D, LEU719C, LEU719D, LEU741C, LEU741D, LEU745C, LEU745D, LEU788C, LEU788D, LEU791C, LEU791D, LEU825C, LEU825D, LEU975C, LEU975D, LEU987C, LEU987D, LEU991C, LEU991D, LEU997C, LEU997D, LYS717C, LYS717D, LYS792C, LYS792D, LYS834C, LYS834D, LYS992C, LYS992D, MET1063C, MET1063D, MET972C, MET972D, PHE1062C, PHE1062D, PHE1080C, PHE1080D, PHE1112C, PHE1112D, PHE694C, PHE694D, PHE811C, PHE811D, PRO1075C, PRO1075D, PRO1077C, PRO1077D, PRO698C, PRO698D, PRO726C, PRO726D, SER1115C, SER1115D, SER722C, SER722D, SER734C, SER734D, SER783C, SER783D, SER790C, SER790D, SER808C, SER809C, SER809D, SER984C, SER984D, SER994D, THR720C, THR720D, THR736C, THR736D, THR812C, THR812D, THR817C, THR817D, TYR1059C, TYR1059D, TYR731C, TYR731D, TYR732C, TYR732D, TYR742C, TYR742D, VAL1076C, VAL1076D, VAL728C, VAL728D, VAL785C, VAL785D
• C-E: ALA1070C, ALA1070E, ALA819C, ALA819E, ARG1087C, ARG1087E, ARG947C, ARG947E, ASP1024C, ASP1024E, ASP1030C, ASP1030E, ASP1035C, ASP1035E, ASP1068C, ASP1068E, ASP1082C, ASP1082E, ASP946C, ASP946E, GLN769E, GLN815C, GLN815E, GLU1067C, GLU1067E, GLU1071C, GLU1071E, GLU771C, GLU771E, GLY1074C, GLY1074E, GLY1079C, GLY1079E, HIS945C, HIS945E, ILE1069C, ILE1069E, ILE950E, LEU1072C, LEU1072E, LEU766C, LEU766E, LEU949E, LYS1028C, LYS1028E, LYS1031C, LYS1031E, LYS1086C, LYS1086E, LYS770C, LYS770E, MET1034C, MET1034E, MET1073C, MET1073E, PHE1029C, PHE1029E, PHE1033C, PHE1033E, PHE1084E, PHE1088C, PHE1088E, PRO1066C, PRO1066E, PRO1075C, PRO1075E, PRO1089C, PRO1089E, SER1022C, SER1022E, SER948C, SER948E, THR1026C, THR1026E, THR1032C, THR1032E, THR1085C, THR1085E, TRP1025E, TYR1083C, TYR1083E, VAL1027C, VAL1027E
• C-F: ARG1110F, ARG843F, ARG896F, ARG899F, ARG976F, ASN749C, ASN760C, ASN765C, ASP1105F, ASP763C, GLN1107F, GLN691C, GLN769C, GLN839F, GLU677C, GLY838F, HIS789F, HIS945C, LEU835F, LEU966F, LYS678C, LYS792F, LYS942C, LYS973F, MET972F, SER762C, SER790F, SER809C, SER837F, THR970F, TYR1114F, VAL761C
• D-E: ALA971D, ARG1110D, ARG843D, ARG896D, ARG899D, ARG947E, ARG968D, ARG976D, ASN1102D, ASN749E, ASN760E, ASN765E, ASP1105D, ASP1106D, ASP763E, GLN1107D, GLN691E, GLN769E, GLN839D, GLU1111D, GLU677E, GLU764E, GLY838D, HIS789D, HIS945E, ILE679E, LEU1103D, LEU680E, LEU747E, LEU768E, LEU835D, LEU966D, LYS678E, LYS759E, LYS792D, LYS916E, LYS942E, LYS967D, LYS973D, MET972D, PRO698E, PRO965D, PRO969D, SER1104D, SER1115D, SER676E, SER762E, SER790D, SER808E, SER809E, SER837D, THR898D, THR970D, TYR1114D, VAL761E
• E-F: ALA1070E, ALA1070F, ALA744E, ALA744F, ALA782E, ALA782F, ALA786E, ALA786F, ALA813E, ALA813F, ALA971E, ALA971F, ARG1053E, ARG1053F, ARG1056E, ARG1056F, ARG1110E, ARG1110F, ARG697E, ARG697F, ARG730E, ARG730F, ARG779E, ARG779F, ARG810E, ARG810F, ARG823E, ARG823F, ARG976E, ARG976F, ARG996E, ARG996F, ASN1061E, ASN1061F, ASN672E, ASN672F, ASN727E, ASN727F, ASP1064E, ASP1064F, ASP1078E, ASP1078F, ASP1106E, ASP1106F, ASP723E, ASP723F, ASP724E, ASP724F, ASP814E, ASP814F, ASP995E, ASP995F, CYS733E, CYS733F, GLN1107E, GLN1107F, GLN695E, GLN695F, GLN780E, GLN780F, GLN815E, GLN815F, GLN816E, GLN816F, GLU1000E, GLU1000F, GLU1071E, GLU1071F, GLU1111E, GLU1111F, GLU721E, GLU721F, GLU735E, GLU735F, GLU746E, GLU746F, GLU988E, GLU988F, GLU998E, GLU998F, GLY1074E, GLY1074F, GLY1079E, GLY1079F, GLY696E, GLY696F, GLY784E, GLY784F, GLY818E, GLY818F, HIS1060E, HIS1060F, HIS725E, HIS725F, HIS787E, HIS787F, HIS789E, HIS789F, ILE1108E, ILE1108F, ILE716E, ILE716F, ILE729E, ILE729F, ILE743E, ILE743F, ILE999E, ILE999F, LEU1109E, LEU1109F, LEU673E, LEU673F, LEU719E, LEU719F, LEU741E, LEU741F, LEU745E, LEU788E, LEU788F, LEU791E, LEU791F, LEU825E, LEU825F, LEU975E, LEU975F, LEU987E, LEU987F, LEU991E, LEU991F, LEU997E, LEU997F, LYS717E, LYS717F, LYS792E, LYS792F, LYS834E, LYS834F, LYS985E, LYS985F, LYS992E, LYS992F, MET1063E, MET1063F, MET1073E, MET1073F, MET972E, MET972F, PHE1062E, PHE1062F, PHE1080E, PHE1080F, PHE1112E, PHE1112F, PHE694E, PHE694F, PHE811E, PHE811F, PRO1075E, PRO1075F, PRO1077E, PRO1077F, PRO698E, PRO698F, PRO726E, PRO726F, PRO982E, PRO982F, SER1115E, SER1115F, SER722E, SER722F, SER734E, SER734F, SER783E, SER783F, SER790E, SER790F, SER809E, SER809F, SER984E, SER984F, THR720E, THR720F, THR736E, THR736F, THR812E, THR812F, THR817E, THR817F, TYR1059E, TYR1059F, TYR731E, TYR731F, TYR732E, TYR732F, TYR742E, TYR742F, VAL1076E, VAL1076F, VAL728E, VAL728F, VAL785E, VAL785F
• E-G: ALA971E, ARG1110E, ARG810G, ARG843E, ARG896E, ARG899E, ARG968E, ARG976E, ASN749G, ASN760G, ASN765G, ASP1105E, ASP763G, GLN1107E, GLN691G, GLN769G, GLN839E, GLU677G, GLU764G, GLY692G, GLY838E, HIS789E, HIS945G, ILE679G, LEU680G, LEU747G, LEU766G, LEU768G, LEU835E, LEU966E, LYS678G, LYS759G, LYS792E, LYS916G, LYS942G, LYS967E, LYS973E, MET972E, PRO698G, PRO965E, PRO969E, SER1115E, SER676G, SER762G, SER790E, SER808G, SER809G, SER837E, SER900E, THR807G, THR898E, THR970E, TYR1114E, VAL761G, VAL974E
• F-G: ALA1070F, ALA1070G, ALA813F, ALA819F, ALA819G, ARG1087F, ARG1087G, ARG947F, ARG947G, ASP1024F, ASP1024G, ASP1030F, ASP1030G, ASP1035F, ASP1035G, ASP1068F, ASP1068G, ASP1082F, ASP1082G, ASP946F, ASP946G, GLN815F, GLN815G, GLU1067F, GLU1067G, GLU1071F, GLU1071G, GLU771F, GLU771G, GLY1074F, GLY1074G, GLY1079F, GLY1079G, HIS945F, HIS945G, ILE1069F, ILE1069G, LEU1072F, LEU1072G, LEU766F, LEU766G, LEU949F, LEU949G, LYS1028F, LYS1028G, LYS1031F, LYS1031G, LYS1086F, LYS1086G, LYS770F, LYS770G, MET1034F, MET1034G, MET1073F, MET1073G, PHE1029F, PHE1029G, PHE1033F, PHE1033G, PHE1084F, PHE1084G, PHE1088G, PRO1066F, PRO1066G, PRO1075F, PRO1075G, PRO1089F, PRO1089G, SER1022G, SER948F, SER948G, THR1026F, THR1026G, THR1032F, THR1032G, THR1085F, THR1085G, TYR1083F, TYR1083G, VAL1027F, VAL1027G
• F-H: ALA971H, ARG1110H, ARG810F, ARG843H, ARG896H, ARG899H, ARG976H, ASN749F, ASN760F, ASN765F, ASP1105H, ASP763F, GLN1107H, GLN691F, GLN769F, GLN839H, GLU677F, GLU764F, GLY838H, HIS789H, HIS945F, ILE679F, LEU680F, LEU747F, LEU766F, LEU835H, LEU966H, LYS678F, LYS759F, LYS792H, LYS942F, LYS973H, MET972H, PRO698F, PRO969H, SER676F, SER762F, SER790H, SER808F, SER809F, SER837H, THR898H, THR970H, TYR1114H, VAL761F
• G-H: ALA1070G, ALA1070H, ALA744G, ALA744H, ALA782G, ALA782H, ALA786G, ALA786H, ALA813G, ALA813H, ALA971G, ARG1053G, ARG1053H, ARG1056G, ARG1056H, ARG1110G, ARG1110H, ARG697G, ARG697H, ARG730G, ARG730H, ARG779G, ARG779H, ARG810G, ARG810H, ARG823G, ARG823H, ARG976G, ARG976H, ARG996G, ARG996H, ASN1061G, ASN1061H, ASN672G, ASN672H, ASN727G, ASN727H, ASP1064G, ASP1064H, ASP1078G, ASP1078H, ASP1106G, ASP1106H, ASP723G, ASP723H, ASP724G, ASP724H, ASP814G, ASP814H, ASP995G, ASP995H, CYS733G, CYS733H, GLN1107G, GLN1107H, GLN695G, GLN695H, GLN780G, GLN780H, GLN815G, GLN815H, GLN816G, GLN816H, GLU1000G, GLU1000H, GLU1071G, GLU1071H, GLU1111G, GLU1111H, GLU721G, GLU721H, GLU735G, GLU735H, GLU746G, GLU746H, GLU988G, GLU988H, GLU998G, GLU998H, GLY1074G, GLY1074H, GLY1079H, GLY696G, GLY696H, GLY784G, GLY784H, GLY818H, HIS1060G, HIS1060H, HIS725G, HIS725H, HIS787G, HIS787H, HIS789G, HIS789H, ILE1108G, ILE1108H, ILE716G, ILE716H, ILE729G, ILE729H, ILE743G, ILE743H, ILE999G, ILE999H, LEU1109G, LEU1109H, LEU673G, LEU673H, LEU719G, LEU719H, LEU741G, LEU741H, LEU745G, LEU745H, LEU788G, LEU788H, LEU791G, LEU791H, LEU825G, LEU825H, LEU975G, LEU975H, LEU987G, LEU987H, LEU991G, LEU991H, LEU997G, LEU997H, LYS717G, LYS717H, LYS792G, LYS792H, LYS834G, LYS834H, LYS992G, LYS992H, MET1063G, MET1063H, MET1073G, MET1073H, MET972G, MET972H, PHE1062G, PHE1062H, PHE1080G, PHE1080H, PHE1112G, PHE1112H, PHE694G, PHE694H, PHE811G, PHE811H, PRO1075G, PRO1075H, PRO1077G, PRO1077H, PRO698G, PRO698H, PRO726G, PRO726H, PRO982G, PRO982H, SER1115G, SER1115H, SER722G, SER722H, SER734G, SER734H, SER783G, SER783H, SER790G, SER790H, SER808H, SER809G, SER809H, SER984G, SER984H, SER994H, THR720G, THR720H, THR736G, THR736H, THR812G, THR812H, THR817G, THR817H, TYR1059G, TYR1059H, TYR731G, TYR731H, TYR732G, TYR732H, TYR742G, TYR742H, VAL1076G, VAL1076H, VAL728G, VAL728H, VAL785G, VAL785H
• G-I: ALA971G, ARG1110G, ARG810I, ARG843G, ARG896G, ARG899G, ARG968G, ARG976G, ASN749I, ASN760I, ASN765I, ASP1105G, ASP763I, GLN1107G, GLN691I, GLN769I, GLN839G, GLU677I, GLU764I, GLY692I, GLY838G, HIS789G, HIS945I, ILE679I, LEU680I, LEU747I, LEU766I, LEU835G, LEU966G, LYS678I, LYS759I, LYS792G, LYS916I, LYS942I, LYS967G, LYS973G, MET972G, PRO698I, PRO969G, SER1115G, SER676I, SER762I, SER790G, SER808I, SER809I, SER837G, THR807I, THR898G, THR970G, TYR1114G, VAL761I
• H-I: ALA1070H, ALA1070I, ALA813H, ALA813I, ALA819H, ALA819I, ARG1087H, ARG1087I, ARG947H, ARG947I, ASP1024H, ASP1024I, ASP1030H, ASP1030I, ASP1035H, ASP1035I, ASP1068H, ASP1068I, ASP1082H, ASP1082I, ASP946H, ASP946I, GLN769H, GLN769I, GLN815H, GLN815I, GLU1067H, GLU1067I, GLU1071H, GLU1071I, GLU771H, GLU771I, GLY1074H, GLY1074I, GLY1079H, GLY1079I, HIS945H, HIS945I, ILE1069H, ILE1069I, ILE950H, LEU1072H, LEU1072I, LEU766H, LEU766I, LEU949H, LEU949I, LYS1028H, LYS1028I, LYS1031H, LYS1031I, LYS1086H, LYS1086I, LYS770H, LYS770I, MET1034H, MET1034I, MET1073H, MET1073I, PHE1029H, PHE1029I, PHE1033H, PHE1033I, PHE1084H, PHE1084I, PHE1088H, PHE1088I, PRO1066H, PRO1066I, PRO1075H, PRO1075I, PRO1089H, PRO1089I, SER1022H, SER1022I, SER948H, SER948I, THR1026H, THR1026I, THR1032H, THR1032I, THR1085H, THR1085I, TYR1083H, TYR1083I, VAL1027H, VAL1027I
• H-J: ALA971J, ARG1110J, ARG810H, ARG843J, ARG896J, ARG899J, ARG976J, ASN749H, ASN760H, ASN765H, ASP1105J, ASP763H, GLN1107J, GLN691H, GLN769H, GLN839J, GLU1111J, GLU677H, GLU764H, GLY692H, GLY838J, HIS789J, HIS945H, ILE679H, LEU680H, LEU747H, LEU768H, LEU835J, LEU966J, LYS678H, LYS759H, LYS792J, LYS916H, LYS942H, LYS973J, MET972J, PRO698H, PRO969J, SER1115J, SER676H, SER762H, SER790J, SER808H, SER809H, SER837J, THR898J, THR970J, TYR1114J, VAL761H
• I-J: ALA1070I, ALA1070J, ALA744I, ALA744J, ALA782I, ALA782J, ALA786I, ALA786J, ALA813I, ALA813J, ALA971J, ARG1053I, ARG1053J, ARG1056I, ARG1056J, ARG1110I, ARG1110J, ARG697I, ARG697J, ARG730I, ARG730J, ARG779I, ARG779J, ARG810I, ARG810J, ARG823I, ARG823J, ARG976I, ARG976J, ARG996I, ARG996J, ASN1061I, ASN1061J, ASN672I, ASN672J, ASN727I, ASN727J, ASP1064I, ASP1064J, ASP1078I, ASP1078J, ASP1106I, ASP1106J, ASP723I, ASP723J, ASP724I, ASP724J, ASP814I, ASP814J, ASP995I, ASP995J, CYS733I, CYS733J, GLN1107I, GLN1107J, GLN695I, GLN695J, GLN815I, GLN815J, GLN816I, GLN816J, GLU1000I, GLU1000J, GLU1071I, GLU1071J, GLU1111I, GLU1111J, GLU721I, GLU721J, GLU735I, GLU735J, GLU746I, GLU746J, GLU988I, GLU988J, GLU998I, GLU998J, GLY1074I, GLY1074J, GLY1079I, GLY696I, GLY784I, GLY784J, GLY818I, HIS1060I, HIS1060J, HIS725I, HIS725J, HIS787I, HIS787J, HIS789I, HIS789J, ILE1108I, ILE1108J, ILE716I, ILE716J, ILE729I, ILE729J, ILE743I, ILE743J, ILE999I, ILE999J, LEU1109I, LEU1109J, LEU673I, LEU673J, LEU719I, LEU719J, LEU741I, LEU741J, LEU745I, LEU745J, LEU788I, LEU788J, LEU791I, LEU791J, LEU825I, LEU825J, LEU975I, LEU975J, LEU987I, LEU987J, LEU991I, LEU991J, LEU997I, LEU997J, LYS717I, LYS717J, LYS792I, LYS792J, LYS834I, LYS834J, LYS992I, LYS992J, MET1063I, MET1063J, MET1073J, MET972I, MET972J, PHE1062I, PHE1062J, PHE1080I, PHE1080J, PHE1112I, PHE1112J, PHE694I, PHE694J, PHE811I, PHE811J, PRO1075I, PRO1075J, PRO1077I, PRO1077J, PRO698I, PRO698J, PRO726I, PRO726J, PRO982I, SER1115J, SER722I, SER722J, SER734I, SER734J, SER783I, SER783J, SER790I, SER790J, SER809I, SER809J, SER984I, SER984J, THR720I, THR720J, THR736I, THR736J, THR812I, THR812J, THR817I, THR817J, TYR1059I, TYR1059J, TYR731I, TYR731J, TYR732I, TYR732J, TYR742I, TYR742J, VAL1076I, VAL1076J, VAL728I, VAL728J, VAL785I, VAL785J
• K-L: ALA1070K, ALA1070L, ALA744K, ALA744L, ALA782K, ALA782L, ALA786K, ALA786L, ALA813K, ALA813L, ALA971K, ARG1053K, ARG1053L, ARG1056K, ARG1056L, ARG1110K, ARG1110L, ARG697K, ARG697L, ARG730K, ARG730L, ARG779K, ARG779L, ARG810K, ARG810L, ARG823K, ARG823L, ARG976K, ARG976L, ARG996K, ARG996L, ASN1061K, ASN1061L, ASN672K, ASN672L, ASN727K, ASN727L, ASP1064K, ASP1064L, ASP1078K, ASP1078L, ASP1106K, ASP1106L, ASP723K, ASP723L, ASP724K, ASP724L, ASP814K, ASP814L, ASP995K, ASP995L, CYS733K, CYS733L, GLN1107K, GLN1107L, GLN695K, GLN695L, GLN780K, GLN780L, GLN815K, GLN815L, GLN816K, GLN816L, GLU1000K, GLU1000L, GLU1071K, GLU1071L, GLU1111K, GLU1111L, GLU721K, GLU721L, GLU735K, GLU735L, GLU746K, GLU746L, GLU988K, GLU988L, GLU998K, GLU998L, GLY1074K, GLY1074L, GLY696K, GLY696L, GLY784K, GLY784L, GLY818L, HIS1060K, HIS1060L, HIS725K, HIS725L, HIS787K, HIS787L, HIS789K, ILE1108K, ILE1108L, ILE716K, ILE716L, ILE729K, ILE729L, ILE743K, ILE743L, ILE999K, ILE999L, LEU1109K, LEU1109L, LEU673K, LEU673L, LEU719K, LEU719L, LEU741K, LEU741L, LEU745K, LEU745L, LEU788K, LEU788L, LEU791K, LEU791L, LEU825K, LEU825L, LEU975K, LEU975L, LEU987K, LEU987L, LEU991K, LEU991L, LEU997K, LEU997L, LYS717K, LYS717L, LYS792K, LYS792L, LYS834K, LYS834L, LYS992K, LYS992L, MET1063K, MET1063L, MET1073L, MET972K, MET972L, PHE1062K, PHE1062L, PHE1080K, PHE1080L, PHE1112K, PHE1112L, PHE694K, PHE694L, PHE811K, PHE811L, PRO1075K, PRO1075L, PRO1077K, PRO1077L, PRO698K, PRO698L, PRO726K, PRO726L, PRO982L, SER1115K, SER1115L, SER722K, SER722L, SER734K, SER734L, SER783K, SER783L, SER790K, SER790L, SER809K, SER809L, SER984K, SER984L, THR720K, THR720L, THR736K, THR736L, THR812K, THR812L, THR817K, THR817L, TYR1059K, TYR1059L, TYR731K, TYR731L, TYR732K, TYR732L, TYR742K, TYR742L, VAL1076K, VAL1076L, VAL728K, VAL728L, VAL785K, VAL785L
• K-M: ALA971K, ARG1110K, ARG810M, ARG843K, ARG896K, ARG899K, ARG947M, ARG968K, ARG976K, ASN1102K, ASN749M, ASN760M, ASN765M, ASP1105K, ASP763M, GLN1107K, GLN691M, GLN769M, GLN839K, GLU677M, GLU764M, GLY838K, HIS789K, HIS945M, ILE679M, LEU680M, LEU747M, LEU766M, LEU768M, LEU835K, LEU966K, LYS678M, LYS759M, LYS792K, LYS916M, LYS942M, LYS967K, LYS973K, MET972K, PRO698M, PRO965K, PRO969K, SER1104K, SER1115K, SER676M, SER762M, SER790K, SER808M, SER809M, SER837K, SER900K, THR807M, THR898K, THR970K, TYR1114K, VAL761M
• L-M: ALA1070L, ALA1070M, ALA819L, ARG1087L, ARG1087M, ARG947L, ARG947M, ASP1024L, ASP1024M, ASP1030L, ASP1030M, ASP1035L, ASP1035M, ASP1068L, ASP1068M, ASP1082L, ASP1082M, ASP946L, ASP946M, GLN815L, GLN815M, GLU1067L, GLU1067M, GLU1071L, GLU1071M, GLU771L, GLY1074L, GLY1074M, GLY1079L, GLY1079M, HIS945L, HIS945M, ILE1069L, ILE1069M, LEU1072L, LEU1072M, LEU766L, LEU766M, LEU949M, LYS1028L, LYS1028M, LYS1031L, LYS1031M, LYS1086L, LYS1086M, LYS770L, LYS770M, MET1034L, MET1034M, MET1073L, MET1073M, PHE1029L, PHE1029M, PHE1033L, PHE1033M, PHE1084L, PHE1084M, PHE1088M, PRO1066L, PRO1066M, PRO1075L, PRO1075M, PRO1089L, PRO1089M, SER1022M, SER948L, SER948M, THR1026L, THR1026M, THR1032L, THR1032M, THR1085L, THR1085M, TRP1025M, TYR1083L, TYR1083M, VAL1027L, VAL1027M
• L-N: ALA971N, ARG1110N, ARG843N, ARG896N, ARG899N, ARG976N, ASN760L, ASN765L, ASP1105N, ASP763L, GLN1107N, GLN691L, GLN769L, GLN839N, GLY838N, HIS945L, LEU835N, LEU966N, LYS678L, LYS792N, LYS942L, LYS973N, MET972N, SER762L, SER809L, SER837N, THR970N, TYR1114N, VAL761L
• M-N: ALA1070M, ALA1070N, ALA744M, ALA744N, ALA782M, ALA782N, ALA786M, ALA786N, ALA813M, ALA813N, ALA971M, ALA971N, ARG1053M, ARG1053N, ARG1056M, ARG1056N, ARG1110M, ARG1110N, ARG697M, ARG697N, ARG730M, ARG730N, ARG779M, ARG779N, ARG810M, ARG810N, ARG823M, ARG823N, ARG976M, ARG976N, ARG996M, ARG996N, ASN1061M, ASN1061N, ASN672M, ASN672N, ASN727M, ASN727N, ASP1064M, ASP1064N, ASP1078M, ASP1078N, ASP1106M, ASP1106N, ASP723M, ASP723N, ASP724M, ASP724N, ASP814M, ASP814N, ASP995M, ASP995N, CYS733M, CYS733N, GLN1107M, GLN1107N, GLN695M, GLN695N, GLN780M, GLN780N, GLN815M, GLN815N, GLN816M, GLN816N, GLU1000M, GLU1000N, GLU1071M, GLU1071N, GLU1111M, GLU1111N, GLU721M, GLU721N, GLU735M, GLU735N, GLU746M, GLU746N, GLU988M, GLU988N, GLU998M, GLU998N, GLY1074M, GLY1074N, GLY1079M, GLY1079N, GLY696M, GLY696N, GLY784M, GLY784N, GLY818M, GLY818N, HIS1060M, HIS1060N, HIS725M, HIS725N, HIS787M, HIS787N, HIS789M, HIS789N, ILE1108M, ILE1108N, ILE716M, ILE716N, ILE729M, ILE729N, ILE743M, ILE743N, ILE999M, ILE999N, LEU1109M, LEU1109N, LEU673M, LEU673N, LEU719M, LEU719N, LEU741M, LEU741N, LEU745M, LEU745N, LEU788M, LEU788N, LEU791M, LEU791N, LEU825M, LEU825N, LEU975M, LEU975N, LEU987M, LEU987N, LEU991M, LEU991N, LEU997M, LEU997N, LYS717M, LYS717N, LYS792M, LYS792N, LYS834M, LYS834N, LYS992M, LYS992N, MET1063M, MET1063N, MET1073M, MET1073N, MET972M, MET972N, PHE1062M, PHE1062N, PHE1080M, PHE1080N, PHE1112M, PHE1112N, PHE694M, PHE694N, PHE811M, PHE811N, PRO1075M, PRO1075N, PRO1077M, PRO1077N, PRO698M, PRO698N, PRO726M, PRO726N, PRO982M, PRO982N, SER1115M, SER1115N, SER722M, SER722N, SER734M, SER734N, SER783M, SER783N, SER790M, SER790N, SER809M, SER809N, SER984M, SER984N, THR720M, THR720N, THR736M, THR736N, THR812M, THR812N, THR817M, THR817N, TYR1059M, TYR1059N, TYR731M, TYR731N, TYR732M, TYR732N, TYR742M, TYR742N, VAL1076M, VAL1076N, VAL728M, VAL728N, VAL785M, VAL785N