3S37

structural basis for the function of two anti-vegf receptor antibodies

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: H-X
  • Int. Res.: 61
  • Norm. En. per Res.: -3.698
• Hub Node: L(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
L-H	-26.076	15.4279	-389.937	-400.5851	177	10	14	15712	2	18	15
L-X	0.0	-16.8	-52.251	-69.051	27	0	1	2244	1	6	5
H-X	-41.9721	-5.8955	-177.709	-225.5766	61	16	2	6939	0	7	3

Interface residues

• L-H: ALA102H, ALA128H, ALA130L, ALA139H, ALA140H, ALA171H, ALA43L, ALA51L, ALA61H, ALA91L, ALA97H, ARG142L, ARG213H, ARG38H, ARG98H, ASN137L, ASN138L, ASN158L, ASN35H, ASN53L, ASP101H, ASP104H, ASP122L, ASP147H, ASP167L, ASP170L, ASP50L, ASP55L, ASP62H, CYS134L, CYS143H, CYS88L, CYS96H, GLN108H, GLN124L, GLN160L, GLN166L, GLN174H, GLN37L, GLN38L, GLN39H, GLN6H, GLN89L, GLN90L, GLU123L, GLU161L, GLU165L, GLU46H, GLY100L, GLY101L, GLY107H, GLY109H, GLY137H, GLY142H, GLY157L, GLY165H, GLY177H, GLY34L, GLY41L, GLY42H, GLY44H, GLY99L, HIS167H, ILE105H, ILE117L, ILE48L, ILE58H, LEU125L, LEU127H, LEU135L, LEU136L, LEU141H, LEU144H, LEU173H, LEU175L, LEU178H, LEU179L, LEU181H, LEU181L, LEU33L, LEU45H, LEU46L, LEU47L, LYS126L, LYS146H, LYS169L, LYS212H, LYS39L, LYS42L, LYS43H, LYS45L, LYS65H, PHE103H, PHE116L, PHE118L, PHE125H, PHE139L, PHE169H, PHE209L, PHE87L, PHE94L, PHE98L, PRO119L, PRO120L, PRO126H, PRO129H, PRO170H, PRO216H, PRO40L, PRO44L, PRO95L, PRO96L, SER114L, SER121L, SER123H, SER127L, SER130H, SER131L, SER159L, SER162L, SER164H, SER168L, SER171L, SER174L, SER175H, SER176H, SER176L, SER177L, SER180H, SER182H, SER183H, SER189H, SER49H, SER50H, THR100H, THR110H, THR129L, THR138H, THR163H, THR164L, THR168H, THR172L, THR178L, THR180L, THR186H, THR56L, THR97L, TRP106H, TRP32L, TRP35L, TRP36H, TRP47H, TYR173L, TYR179H, TYR36L, TYR49L, TYR59H, TYR60H, TYR94H, TYR95H, VAL115L, VAL124H, VAL132L, VAL133L, VAL145H, VAL163L, VAL166H, VAL172H, VAL184H, VAL185H, VAL187H, VAL214H, VAL37H, VAL48H, VAL85L, VAL93H, VAL99H
• L-X: ALA91L, ALA93L, ARG222X, ASN253X, ASN31L, ASP225X, ASP30L, ASP50L, GLN89L, GLN90L, GLU251X, GLY220X, GLY312X, ILE223X, ILE29L, LEU313X, LYS316X, LYS92L, MET314X, PHE94L, PRO95L, PRO96L, TRP32L, TYR221X, TYR224X, TYR49L, VAL254X
• H-X: ALA102H, ALA308X, ALA309X, ARG222X, ARG72H, ARG98H, ASN253X, ASN259X, ASN35H, ASN74H, ASP101H, ASP257X, CYS307X, GLU261X, GLY255X, GLY312X, HIS269X, ILE223X, ILE256X, ILE51H, ILE58H, ILE70H, LEU277X, LEU313X, LYS316X, LYS317X, MET314X, MET34H, PHE103H, PHE258X, PHE27H, PHE288X, PHE29H, SER30H, SER310X, SER311X, SER31H, SER33H, SER49H, SER50H, SER52H, SER53H, SER54H, SER55H, SER56H, THR100H, THR279X, THR28H, THR306X, THR315X, TRP260X, TRP36H, TRP47H, TYR221X, TYR262X, TYR32H, TYR57H, TYR59H, TYR60H, VAL254X, VAL99H