3S35

structural basis for the function of two anti-vegf receptor antibodies

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: H-X
  • Int. Res.: 59
  • Norm. En. per Res.: -4.2385
• Hub Node: H(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
H-L	-43.3703	-24.2137	-412.279	-479.8629	176	13	8	16815	1	26	18
H-X	-50.7433	-32.3356	-166.994	-250.0729	59	4	2	6684	4	26	19
L-X	-16.731	-18.763	-97.9956	-133.4896	54	3	1	4257	0	11	15

Interface residues

• H-L: ALA104L, ALA129H, ALA134L, ALA172H, ARG215L, ARG217H, ARG40H, ARG54L, ASN103H, ASN137H, ASN141L, ASN142L, ASN165L, ASN214L, ASN57L, ASN61H, ASP100H, ASP105H, ASP169L, ASP171L, ASP174L, ASP1L, ASP98L, CYS138L, CYS144H, CYS92L, CYS96H, GLN109H, GLN128L, GLN175H, GLN39H, GLN41L, GLN42L, GLN43H, GLN46L, GLN6H, GLN93L, GLN94L, GLU127L, GLU217L, GLU46H, GLU59L, GLU62H, GLU97L, GLY101H, GLY103L, GLY105L, GLY108H, GLY110H, GLY132L, GLY133L, GLY143H, GLY166H, GLY42H, GLY44H, GLY45L, GLY49H, HIS168H, HIS35H, HIS38L, HIS99H, ILE121L, ILE214H, ILE33H, ILE48H, ILE52L, LEU100L, LEU128H, LEU129L, LEU140L, LEU142H, LEU145H, LEU164L, LEU174H, LEU178H, LEU181H, LEU183L, LEU185L, LEU45H, LEU50L, LEU51L, LYS107L, LYS147H, LYS173L, LYS211L, LYS212H, LYS213H, LYS38H, LYS43L, LYS49L, LYS59H, LYS63H, MET139H, MET179L, MET37L, PHE102L, PHE104H, PHE122L, PHE139L, PHE143L, PHE170H, PHE213L, PHE36L, PHE64H, PHE95H, PRO123L, PRO124L, PRO127H, PRO130H, PRO171H, PRO44L, PRO47L, PRO48L, PRO99L, SER120L, SER124H, SER125L, SER126L, SER131L, SER135L, SER165H, SER166L, SER176H, SER178L, SER180L, SER181L, SER182H, SER183H, SER184H, SER95L, THR101L, THR102H, THR118L, THR130L, THR141H, THR168L, THR169H, THR176L, THR180H, THR182L, THR184L, THR186H, THR89L, THR97H, TRP107H, TRP158H, TRP167L, TRP192H, TRP36H, TRP39L, TRP47H, TRP50H, TYR106H, TYR126H, TYR177L, TYR179H, TYR190L, TYR40L, TYR53L, TYR60H, TYR90L, TYR91L, VAL119L, VAL125H, VAL136L, VAL137L, VAL140H, VAL146H, VAL163L, VAL167H, VAL173H, VAL185H, VAL215H, VAL37H, VAL3L, VAL93H
• H-X: ARG275X, ARG299X, ARG98H, ASN103H, ASN56H, ASP100H, ASP105H, ASP295X, ASP301X, GLN268X, GLU240X, GLU31H, GLU326X, GLU54H, GLY101H, GLY239X, GLY296X, HIS267X, HIS325X, HIS35H, HIS99H, ILE28H, ILE294X, ILE33H, ILE57H, ILE58H, LEU242X, LEU272X, LEU51H, LYS241X, LYS266X, LYS270X, LYS271X, LYS327X, LYS59H, LYS74H, PHE104H, PHE329X, PRO328X, PRO53H, SER237X, SER264X, SER265X, SER300X, SER55H, THR102H, THR293X, THR298X, THR30H, TRP50H, TYR106H, TYR27H, TYR32H, TYR52H, TYR60H, VAL238X, VAL297X, VAL324X, VAL330X
• L-X: ARG275X, ARG54L, ASN245X, ASN274X, ASN34L, ASN57L, ASN96L, ASP276X, ASP295X, ASP30L, ASP98L, GLN268X, GLN93L, GLN94L, GLU240X, GLU59L, GLU97L, GLY239X, GLY296X, GLY33L, HIS269X, HIS38L, ILE294X, ILE52L, LEU100L, LEU236X, LEU242X, LEU244X, LEU272X, LEU289X, LEU292X, LEU50L, LEU51L, LEU58L, LYS241X, LYS270X, LYS271X, LYS278X, PHE329X, PHE36L, PRO230X, SER31L, SER35L, SER56L, SER60L, SER95L, THR291X, THR293X, TYR32L, TYR53L, VAL243X, VAL273X, VAL29L, VAL330X