3S2K

structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6.

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 117
  • Norm. En. per Res.: -3.1135
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-6.0556	8.5483	-14.7107	-12.2179	19	3	0	736	0	14	14
A-C	-58.9458	-60.8639	-196.588	-316.3977	114	13	0	9115	6	69	44
B-C	-54.2545	-71.8699	-238.154	-364.2784	117	13	2	10221	8	43	38

Interface residues

• A-B: ARG638A, ARG639A, ARG852B, ARG853A, ARG853B, ASP874A, ASP874B, GLU663A, HIS872B, ILE681A, LEU873B, PRO833B, SER851A, SER851B, TRP850A, TRP850B, TYR706A, TYR875A, TYR875B
• A-C: ALA1183A, ALA202C, ALA666A, ALA752A, ALA793A, ALA829A, ARG1184A, ARG191C, ARG203C, ARG224C, ARG225C, ARG236C, ARG246C, ARG259C, ARG751A, ARG792A, ASN727A, ASN794A, ASN813A, ASP680A, ASP705A, ASP748A, ASP809A, ASP811A, ASP830A, ASP831A, ASP874A, ASP878A, CYS200C, CYS201C, CYS220C, CYS237C, CYS239C, CYS245C, CYS263C, GLN1165A, GLN235C, GLN248C, GLN264C, GLU232C, GLU241C, GLU663A, GLU708A, GLY227C, GLY230C, GLY240C, GLY242C, GLY709A, GLY725A, GLY768A, GLY769A, GLY791A, GLY795A, GLY837A, HIS223C, HIS229C, HIS261C, HIS266C, HIS834A, ILE233C, ILE247C, ILE681A, ILE879A, LEU190C, LEU214C, LEU231C, LEU243C, LEU667A, LEU683A, LEU747A, LEU753A, LEU796A, LEU810A, LEU814A, LEU832A, LEU838A, LYS1180A, LYS208C, LYS222C, LYS226C, LYS249C, LYS684A, LYS770A, MET710A, MET877A, PHE836A, PRO707A, PRO750A, PRO771A, PRO833A, PRO835A, SER192C, SER193C, SER228C, SER244C, SER637A, SER665A, SER682A, SER749A, SER851A, THR221C, THR262C, THR724A, THR765A, THR808A, THR812A, TRP206C, TRP767A, TRP850A, TYR238C, TYR706A, TYR875A, VAL827A, VAL876A
• B-C: ALA1186B, ALA196C, ALA202C, ALA664B, ALA666B, ALA793B, ARG1184B, ARG203C, ARG224C, ARG225C, ARG236C, ARG259C, ARG638B, ARG639B, ARG751B, ARG792B, ARG825B, ARG852B, ARG853B, ASN727B, ASN789B, ASN794B, ASN813B, ASP705B, ASP748B, ASP809B, ASP811B, ASP830B, ASP831B, ASP849B, ASP874B, CYS189C, CYS210C, CYS220C, CYS263C, GLN1163B, GLN1164B, GLN1165B, GLN184C, GLN218C, GLN235C, GLN248C, GLU185C, GLU232C, GLU663B, GLU708B, GLU816B, GLY183C, GLY186C, GLY198C, GLY217C, GLY227C, GLY230C, GLY709B, GLY725B, GLY768B, GLY769B, GLY791B, HIS204C, HIS223C, HIS229C, HIS261C, HIS834B, ILE1185B, ILE209C, ILE233C, ILE247C, ILE681B, LEU199C, LEU214C, LEU231C, LEU260C, LEU810B, LEU814B, LEU832B, LYS182C, LYS208C, LYS211C, LYS215C, LYS222C, LYS662B, LYS684B, LYS770B, LYS772B, MET877B, PHE205C, PHE234C, PHE836B, PRO212C, PRO707B, PRO771B, PRO788B, PRO833B, PRO835B, SER187C, SER197C, SER207C, SER228C, SER665B, SER682B, SER749B, SER851B, THR221C, THR262C, THR679B, THR724B, THR812B, TRP206C, TRP767B, TRP850B, TYR706B, TYR875B, VAL188C, VAL219C, VAL790B, VAL827B, VAL876B