3RWR

crystal structure of the human xrcc4-xlf complex

• Total interactions analyzed: 276
• Total true interactions: 34
• Strongest Interaction:
  • Chains: O-Q
  • Int. Res.: 216
  • Norm. En. per Res.: -5.2274
• Hub Node: F(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-22.2843	-17.6244	-299.017	-338.9258	102	28	11	14273	1	43	37
A-E	-9.0514	-14.815	-166.5	-190.3664	52	26	7	6758	3	23	12
B-H	-9.3655	-6.3022	-142.173	-157.8407	54	38	5	7271	1	22	14
D-E	-57.6716	-95.1475	-899.663	-1052.4821	216	169	40	40735	10	61	52
F-G	-22.881	-49.7447	-413.575	-486.2007	117	37	12	16538	6	46	37
F-I	-11.0456	-32.1221	-196.423	-239.5907	61	17	6	8311	1	22	16
F-S	0.0	-4.8294	-85.2476	-90.077	59	4	0	4151	1	12	15
F-U	0.0	0.0	-0.2187	-0.2187	13	0	0	79	0	2	0
F-Y	0.0	13.2184	-20.8156	-7.5972	26	1	0	897	0	8	7
G-U	0.0	4.7502	-57.6868	-52.9366	31	1	1	2445	0	16	19
G-Y	0.0	48.7855	-73.779	-24.9935	40	6	0	2941	2	34	36
H-I	-47.8351	-79.3855	-921.468	-1048.6885	219	109	43	40242	7	60	56
H-R	-5.1804	8.9836	-74.4717	-70.6685	44	7	1	3653	1	10	11
H-W	0.0	18.462	-40.8792	-22.4172	47	2	0	2191	0	15	8
I-S	-7.5065	6.1679	-82.2934	-83.632	54	17	0	3877	0	17	14
I-W	0.0	-32.7839	-64.6691	-97.453	42	3	10	3236	3	8	10
J-K	-21.3655	-48.029	-361.911	-431.3055	118	49	12	16402	3	52	34
J-M	-14.6193	-50.6063	-154.694	-219.9196	57	20	4	7083	2	17	12
J-X	0.0	-6.0876	-7.9978	-14.0854	17	0	0	437	1	7	7
K-T	0.0	-6.0645	-15.8827	-21.9472	22	3	0	936	0	3	5
K-X	0.0	-2.1052	-35.7949	-37.9001	37	1	0	1662	0	20	19
L-M	-53.4499	-107.1034	-895.474	-1056.0273	208	125	38	39775	8	55	54
L-O	0.0	-0.2936	-27.299	-27.5926	47	1	0	1690	0	16	6
L-Q	0.0	-1.5763	-77.4143	-78.9906	46	12	9	3730	0	9	10
M-N	0.0	-9.2343	-53.4201	-62.6544	42	3	0	2894	0	8	14
M-Q	0.0	9.7985	-33.8389	-24.0404	42	1	0	1938	0	11	5
N-P	-25.5906	-58.1106	-408.33	-492.0312	118	56	14	16646	3	49	40
N-Q	-24.868	-22.9811	-167.247	-215.0961	54	19	4	6955	1	17	10
O-Q	-88.6247	-108.8787	-931.61	-1129.1134	216	117	39	39808	6	60	55
R-V	-6.6686	-54.5947	-373.35	-434.6133	117	48	12	16363	3	50	35
R-W	-10.3385	-47.6481	-165.917	-223.9036	56	19	6	7319	4	23	11
S-W	-93.4922	-87.3224	-932.799	-1113.6136	215	96	41	39939	6	58	52
T-X	-97.2771	-67.5736	-967.941	-1132.7917	217	117	38	39549	8	62	55
U-Y	-32.9559	-38.184	-362.254	-433.394	117	42	11	15930	2	47	32

Interface residues

• A-B: ALA120A, ALA135A, ALA139A, ALA42A, ALA620B, ALA635B, ALA639B, ARG124A, ARG507B, ARG624B, ARG7A, ASN118A, ASN137A, ASN141A, ASN618B, ASN637B, ASN641B, ASN648B, ASP132A, ASP38A, ASP538B, ASP632B, CYS128A, CYS130A, CYS628B, CYS630B, GLN138A, GLN145A, GLN521B, GLN638B, GLN645B, GLU121A, GLU125A, GLU136A, GLU13A, GLU142A, GLU147A, GLU621B, GLU625B, GLU636B, GLU642B, GLU647B, GLU649B, GLY39A, GLY539B, HIS143A, HIS18A, HIS40A, HIS509B, HIS518B, HIS540B, HIS643B, HIS9A, ILE123A, ILE127A, ILE134A, ILE16A, ILE505B, ILE516B, ILE5A, ILE623B, ILE627B, ILE634B, ILE8A, LEU126A, LEU131A, LEU144A, LEU20A, LEU520B, LEU626B, LEU631B, LEU644B, LEU651B, LEU652B, LYS115A, LYS140A, LYS146A, LYS4A, LYS504B, LYS640B, LYS646B, PHE19A, PHE519B, PRO119A, PRO619B, SER15A, SER41A, SER506B, SER515B, SER541B, SER576B, SER6A, THR133A, THR17A, THR37A, THR517B, THR537B, THR633B, TYR129A, TYR629B, VAL122A, VAL622B
• A-E: ALA567E, ALA56A, ALA571E, ALA60A, ARG107A, ARG564E, ARG609E, ASN100A, ASN562E, ASN578E, ASP103A, ASP57A, ASP58A, GLN54A, GLU55A, GLU611E, GLU62A, GLU69A, GLU98A, GLY109A, GLY614E, HIS575E, LEU101A, LEU108A, LEU561E, LEU565E, LEU612E, LEU615E, LYS102A, LYS559E, LYS563E, LYS65A, LYS99A, MET59A, MET61A, PHE106A, PHE572E, PHE617E, PHE96A, PHE97A, PRO568E, PRO616E, SER105A, SER110A, SER610E, SER613E, THR566E, THR85A, TYR618E, TYR84A, TYR94A, VAL104A
• B-H: ALA556B, ALA560B, ALA67H, ALA71H, ARG109H, ARG607B, ARG64H, ASN600B, ASN62H, ASN78H, ASP557B, ASP558B, ASP603B, CYS74H, GLU111H, GLU555B, GLU562B, GLU569B, GLU598B, GLU92H, GLY114H, GLY609B, HIS75H, LEU112H, LEU115H, LEU570B, LEU601B, LEU608B, LEU61H, LEU65H, LEU76H, LYS563B, LYS565B, LYS599B, LYS602B, LYS63H, MET559B, MET561B, PHE117H, PHE596B, PHE597B, PHE606B, PHE72H, PRO116H, PRO68H, PRO69H, SER113H, SER605B, THR66H, TYR118H, TYR566B, TYR584B, VAL583B, VAL604B
• D-E: ALA126D, ALA145D, ALA154D, ALA172D, ALA201D, ALA220D, ALA626E, ALA645E, ALA654E, ALA672E, ALA701E, ALA720E, ARG137D, ARG151D, ARG176D, ARG178D, ARG637E, ARG651E, ARG676E, ARG678E, ASN213D, ASN713E, ASP102D, ASP161D, ASP166D, ASP177D, ASP206D, ASP216D, ASP40D, ASP540E, ASP602E, ASP661E, ASP666E, ASP677E, ASP706E, ASP716E, CYS148D, CYS202D, CYS648E, CYS702E, GLN133D, GLN147D, GLN149D, GLN165D, GLN168D, GLN192D, GLN215D, GLN224D, GLN42D, GLN43D, GLN542E, GLN543E, GLN633E, GLN647E, GLN649E, GLN665E, GLN668E, GLN692E, GLN715E, GLN724E, GLU152D, GLU163D, GLU169D, GLU182D, GLU185D, GLU186D, GLU191D, GLU200D, GLU652E, GLU663E, GLU669E, GLU682E, GLU685E, GLU686E, GLU691E, GLU700E, GLY141D, GLY171D, GLY205D, GLY207D, GLY641E, GLY671E, GLY705E, GLY707E, HIS134D, HIS158D, HIS225D, HIS226D, HIS227D, HIS634E, HIS658E, HIS725E, HIS726E, ILE136D, ILE164D, ILE175D, ILE195D, ILE204D, ILE636E, ILE664E, ILE675E, ILE695E, ILE704E, LEU125D, LEU130D, LEU135D, LEU139D, LEU144D, LEU146D, LEU153D, LEU156D, LEU157D, LEU162D, LEU174D, LEU179D, LEU190D, LEU198D, LEU214D, LEU217D, LEU24D, LEU41D, LEU524E, LEU541E, LEU625E, LEU630E, LEU635E, LEU639E, LEU644E, LEU646E, LEU653E, LEU656E, LEU657E, LEU662E, LEU674E, LEU679E, LEU690E, LEU698E, LEU714E, LEU717E, LYS160D, LYS180D, LYS197D, LYS208D, LYS660E, LYS680E, LYS697E, LYS708E, MET140D, MET142D, MET159D, MET194D, MET212D, MET219D, MET640E, MET642E, MET659E, MET694E, MET712E, MET719E, PHE184D, PHE189D, PHE193D, PHE210D, PHE684E, PHE689E, PHE693E, PHE710E, PRO128D, PRO138D, PRO183D, PRO199D, PRO209D, PRO628E, PRO638E, PRO683E, PRO699E, PRO709E, SER127D, SER129D, SER132D, SER143D, SER170D, SER203D, SER39D, SER539E, SER629E, SER632E, SER643E, SER670E, SER703E, THR155D, THR173D, THR181D, THR222D, THR223D, THR655E, THR673E, THR681E, THR722E, THR723E, TRP13D, TRP513E, TYR167D, TYR218D, TYR667E, TYR718E, VAL131D, VAL150D, VAL211D, VAL221D, VAL44D, VAL544E, VAL631E, VAL650E, VAL711E, VAL721E
• F-G: ALA120F, ALA135F, ALA139F, ALA620G, ALA635G, ALA639G, ARG124F, ARG150F, ARG153F, ARG3F, ARG507G, ARG624G, ARG650G, ARG7F, ASN118F, ASN137F, ASN141F, ASN148F, ASN156F, ASN618G, ASN637G, ASN641G, ASN648G, ASN656G, ASP132F, ASP154F, ASP157F, ASP38F, ASP538G, ASP632G, ASP654G, CYS128F, CYS130F, CYS628G, CYS630G, GLN138F, GLN145F, GLN21F, GLN521G, GLN638G, GLN645G, GLU121F, GLU125F, GLU136F, GLU13F, GLU142F, GLU147F, GLU149F, GLU617G, GLU621G, GLU625G, GLU636G, GLU642G, GLU647G, GLU649G, GLY39F, GLY539G, HIS143F, HIS18F, HIS40F, HIS509G, HIS518G, HIS540G, HIS643G, HIS9F, ILE123F, ILE127F, ILE134F, ILE16F, ILE505G, ILE508G, ILE516G, ILE5F, ILE623G, ILE627G, ILE634G, LEU126F, LEU131F, LEU144F, LEU151F, LEU152F, LEU20F, LEU520G, LEU626G, LEU631G, LEU644G, LEU651G, LEU652G, LYS140F, LYS146F, LYS4F, LYS504G, LYS640G, LYS646G, PHE19F, PHE519G, PRO119F, PRO619G, SER15F, SER41F, SER506G, SER515G, SER541G, SER6F, SER76F, THR133F, THR17F, THR37F, THR517G, THR537G, THR633G, TRP155F, TRP655G, TYR129F, TYR629G, VAL122F, VAL622G
• F-I: ALA567I, ALA56F, ALA570I, ALA571I, ALA60F, ARG107F, ARG564I, ARG609I, ASN100F, ASN562I, ASN578I, ASP103F, ASP577I, ASP57F, ASP58F, CYS574I, GLN54F, GLU55F, GLU592I, GLU611I, GLU62F, GLU69F, GLU98F, GLY109F, GLY614I, HIS575I, LEU101F, LEU108F, LEU561I, LEU565I, LEU573I, LEU576I, LEU612I, LEU615I, LYS102F, LYS531I, LYS559I, LYS563I, LYS65F, LYS72F, LYS99F, MET59F, MET61F, PHE106F, PHE572I, PHE617I, PHE96F, PHE97F, PRO568I, PRO569I, PRO616I, SER105F, SER110F, SER610I, SER613I, THR566I, TYR618I, TYR66F, TYR84F, TYR94F, VAL104F
• F-S: ALA67S, ALA70S, ALA71S, ARG107F, ASN100F, ASN112F, ASN87F, ASP103F, ASP50S, ASP58F, CYS74S, CYS93F, GLN32S, GLN48S, GLN54F, GLN56S, GLU13F, GLU2S, GLU3S, GLU60S, GLU91F, GLU98F, GLY33S, LEU101F, LEU10F, LEU73S, LYS102F, LYS31S, LYS59S, LYS90F, LYS99F, MET1S, PHE106F, PHE111F, PHE72S, PHE88F, PHE95F, PHE96F, PHE97F, PRO14F, PRO68S, PRO69S, SER105F, SER110F, SER12F, SER52S, SER55S, SER89F, SER92F, THR30S, THR51S, THR66S, THR85F, TYR94F, VAL104F, VAL11F, VAL49S, VAL53S, VAL54S
• F-U: ARG7F, ASN141F, ASN148F, ASN156U, ASP157U, GLN145F, GLN145U, GLU149U, GLY79F, LEU152U, LYS146U, PRO80F, TRP155U
• F-Y: ALA78F, ALA81F, ARG153F, ARG503Y, ARG653Y, ASN156F, ASN656Y, ASP154F, ASP157F, ASP654Y, ASP657Y, ASP82F, GLU502Y, GLU525Y, GLU636Y, GLY77F, GLY79F, LEU152F, LYS526Y, LYS640Y, MET501Y, PRO80F, SER76F, TRP155F, TRP655Y, TYR629Y
• G-U: ALA635G, ALA639G, ARG153U, ARG503G, ARG650G, ASN141U, ASN148U, ASN156U, ASN637G, ASN641G, ASP154U, ASP157U, ASP632G, CYS628G, CYS630G, GLN145U, GLN638G, GLU149U, GLU636G, GLU642G, GLU647G, HIS643G, ILE634G, LEU151U, LEU152U, LEU631G, LEU644G, LYS640G, THR633G, TRP155U, TYR629G
• G-Y: ALA635Y, ALA639G, ALA639Y, ARG650G, ARG650Y, ARG653G, ARG653Y, ASN637Y, ASN641G, ASN648G, ASN648Y, ASN656G, ASP632Y, ASP654G, ASP654Y, ASP657G, GLN638G, GLN645G, GLU636G, GLU636Y, GLU642G, GLU642Y, GLU647G, GLU647Y, GLU649G, GLU649Y, HIS643G, HIS643Y, LEU644G, LEU644Y, LEU651G, LEU651Y, LEU652G, LEU652Y, LYS640G, LYS640Y, LYS646G, LYS646Y, TRP655G, TRP655Y
• H-I: ALA126H, ALA145H, ALA154H, ALA172H, ALA201H, ALA220H, ALA626I, ALA645I, ALA654I, ALA672I, ALA701I, ALA720I, ARG137H, ARG151H, ARG176H, ARG178H, ARG637I, ARG651I, ARG676I, ARG678I, ASN213H, ASN713I, ASP102H, ASP161H, ASP166H, ASP177H, ASP206H, ASP216H, ASP40H, ASP540I, ASP602I, ASP661I, ASP666I, ASP677I, ASP706I, ASP716I, CYS148H, CYS202H, CYS648I, CYS702I, GLN133H, GLN147H, GLN149H, GLN165H, GLN168H, GLN192H, GLN215H, GLN224H, GLN42H, GLN43H, GLN542I, GLN543I, GLN633I, GLN647I, GLN649I, GLN665I, GLN668I, GLN692I, GLN715I, GLN724I, GLU152H, GLU163H, GLU169H, GLU182H, GLU185H, GLU186H, GLU191H, GLU196H, GLU200H, GLU652I, GLU663I, GLU669I, GLU682I, GLU685I, GLU686I, GLU691I, GLU696I, GLU700I, GLY141H, GLY171H, GLY205H, GLY207H, GLY641I, GLY671I, GLY705I, GLY707I, HIS134H, HIS158H, HIS225H, HIS227H, HIS634I, HIS658I, HIS725I, ILE136H, ILE164H, ILE175H, ILE195H, ILE204H, ILE636I, ILE664I, ILE675I, ILE695I, ILE704I, LEU125H, LEU130H, LEU135H, LEU139H, LEU144H, LEU146H, LEU153H, LEU156H, LEU157H, LEU162H, LEU174H, LEU179H, LEU190H, LEU198H, LEU214H, LEU217H, LEU24H, LEU41H, LEU524I, LEU541I, LEU625I, LEU630I, LEU635I, LEU639I, LEU644I, LEU646I, LEU653I, LEU656I, LEU657I, LEU662I, LEU674I, LEU679I, LEU690I, LEU698I, LEU714I, LEU717I, LYS160H, LYS180H, LYS197H, LYS208H, LYS660I, LYS680I, LYS697I, LYS708I, MET140H, MET142H, MET159H, MET194H, MET212H, MET219H, MET640I, MET642I, MET659I, MET694I, MET712I, MET719I, PHE184H, PHE189H, PHE193H, PHE210H, PHE684I, PHE689I, PHE693I, PHE710I, PRO128H, PRO138H, PRO183H, PRO199H, PRO209H, PRO628I, PRO638I, PRO683I, PRO699I, PRO709I, SER127H, SER129H, SER132H, SER143H, SER170H, SER203H, SER39H, SER539I, SER627I, SER629I, SER632I, SER643I, SER670I, SER703I, THR155H, THR173H, THR181H, THR222H, THR223H, THR655I, THR673I, THR681I, THR722I, THR723I, TRP13H, TRP45H, TRP513I, TRP515I, TYR167H, TYR218H, TYR667I, TYR718I, VAL131H, VAL150H, VAL211H, VAL221H, VAL44H, VAL544I, VAL631I, VAL650I, VAL711I, VAL721I
• H-R: ALA70H, ALA71H, ARG107R, ASN100R, ASN87R, ASP103R, ASP50H, CYS74H, CYS93R, GLN32H, GLN48H, GLU13R, GLU2H, GLU3H, GLU91R, GLU98R, GLY33H, LEU10R, LEU4H, LEU73H, LYS31H, LYS90R, MET1H, PHE28H, PHE88R, PHE95R, PHE96R, PRO14R, PRO68H, PRO69H, SER105R, SER110R, SER12R, SER15R, SER52H, SER55H, SER89R, SER92R, THR30H, THR51H, THR85R, TYR94R, VAL11R, VAL54H
• H-W: ALA101H, ALA103H, ALA126H, ALA567W, ALA570W, ARG557W, ARG564W, ARG57H, ASP102H, ASP50H, ASP550W, CYS123H, GLN48H, GLN532W, GLN556W, GLN56H, GLU2H, GLU47H, GLU560W, HIS122H, HIS46H, LEU104H, LEU125H, LEU130H, LEU565W, LYS559W, LYS563W, MET124H, MET1H, MET501W, PRO128H, PRO568W, PRO569W, SER127H, SER129H, SER52H, SER552W, SER555W, THR551W, THR566W, TRP45H, VAL100H, VAL49H, VAL53H, VAL549W, VAL553W, VAL554W
• I-S: ALA101S, ALA103S, ALA126S, ALA558I, ALA567I, ALA570I, ALA571I, ARG557I, ARG564I, ARG57S, ASP102S, ASP50S, ASP550I, CYS123S, GLN48S, GLN532I, GLN556I, GLN56S, GLU2S, GLU47S, GLU560I, GLU60S, HIS122S, HIS46S, LEU104S, LEU125S, LEU130S, LEU565I, LYS559I, LYS563I, MET124S, MET1S, MET501I, PRO128S, PRO568I, PRO569I, SER127S, SER129S, SER52S, SER552I, SER555I, SER55S, THR51S, THR551I, THR566I, TRP45S, VAL100S, VAL44S, VAL49S, VAL53S, VAL549I, VAL54S, VAL553I, VAL554I
• I-W: ALA601I, ALA601W, ALA603I, ALA603W, ARG557I, ARG557W, ARG607I, ARG607W, ASN620I, ASN620W, ASP598I, ASP598W, ASP602I, ASP602W, CYS599I, CYS599W, CYS623I, CYS623W, GLN543W, GLN556I, GLN556W, GLU547W, GLU560I, HIS622I, HIS622W, ILE605I, ILE605W, LEU604I, LEU604W, LEU606I, LEU606W, LEU625I, LEU625W, MET624I, MET624W, PHE621I, PHE621W, PRO628W, VAL553I, VAL553W, VAL600I, VAL600W
• J-K: ALA120J, ALA135J, ALA139J, ALA542K, ALA620K, ALA635K, ALA639K, ARG124J, ARG150J, ARG153J, ARG507K, ARG624K, ARG650K, ARG653K, ARG7J, ASN137J, ASN141J, ASN148J, ASN156J, ASN618K, ASN637K, ASN641K, ASN648K, ASP132J, ASP154J, ASP38J, ASP538K, ASP632K, ASP654K, CYS128J, CYS130J, CYS628K, CYS630K, GLN138J, GLN145J, GLN21J, GLN521K, GLN638K, GLN645K, GLU121J, GLU125J, GLU136J, GLU13J, GLU142J, GLU147J, GLU149J, GLU513K, GLU617K, GLU621K, GLU625K, GLU636K, GLU642K, GLU647K, GLU649K, GLY39J, GLY539K, HIS143J, HIS18J, HIS40J, HIS518K, HIS540K, HIS643K, HIS9J, ILE123J, ILE127J, ILE134J, ILE16J, ILE505K, ILE508K, ILE516K, ILE5J, ILE623K, ILE627K, ILE634K, ILE8J, LEU126J, LEU131J, LEU144J, LEU151J, LEU152J, LEU20J, LEU510K, LEU520K, LEU626K, LEU631K, LEU644K, LEU651K, LEU652K, LYS140J, LYS146J, LYS4J, LYS504K, LYS640K, LYS646K, PHE19J, PHE519K, PRO119J, PRO619K, SER15J, SER41J, SER506K, SER515K, SER541K, SER6J, SER76J, THR133J, THR17J, THR37J, THR517K, THR537K, THR633K, TRP155J, TRP655K, TYR129J, TYR629K, VAL122J, VAL616K, VAL622K
• J-M: ALA567M, ALA56J, ALA571M, ALA60J, ALA81J, ARG107J, ARG564M, ARG609M, ASN100J, ASN562M, ASP103J, ASP57J, ASP58J, ASP82J, CYS574M, GLN54J, GLU51J, GLU55J, GLU611M, GLU62J, GLU69J, GLU98J, GLY109J, GLY614M, HIS575M, LEU101J, LEU108J, LEU561M, LEU565M, LEU612M, LEU615M, LEU70J, LYS102J, LYS559M, LYS563M, LYS65J, LYS72J, LYS99J, MET59J, MET61J, PHE106J, PHE111J, PHE572M, PHE617M, PHE96J, PHE97J, PRO568M, PRO616M, SER105J, SER110J, SER613M, THR566M, TYR618M, TYR66J, TYR84J, TYR94J, VAL104J
• J-X: ALA120J, ALA570X, ARG124J, ASN118J, ASP550X, GLN532X, GLU117J, GLU121J, GLU502X, GLU503X, LYS115J, LYS531X, MET501X, PRO119J, SER552X, THR551X, VAL116J
• K-T: ALA101T, ALA103T, ARG107T, ARG607K, ASN587K, ASP102T, ASP40T, ASP558K, ASP98T, CYS99T, GLN42T, GLN43T, GLU591K, GLU598K, LEU41T, LYS590K, PHE596K, SER589K, SER592K, TRP45T, TYR594K, VAL100T
• K-X: ARG637X, ASP538K, ASP550X, GLN506X, GLN548X, GLN633X, GLU502X, GLU503X, GLU505X, GLU513K, GLU591K, HIS540K, HIS546X, HIS634X, ILE516K, LEU504X, LEU509X, LEU510K, LEU630X, LYS590K, LYS615K, MET501X, PHE588K, PRO514K, PRO628X, SER512K, SER515K, SER541K, SER552X, SER589K, SER592K, SER627X, SER629X, SER632X, TRP543K, TYR594K, VAL631X
• L-M: ALA126L, ALA145L, ALA154L, ALA172L, ALA201L, ALA220L, ALA626M, ALA645M, ALA654M, ALA672M, ALA701M, ALA720M, ARG137L, ARG151L, ARG176L, ARG637M, ARG651M, ARG676M, ARG678M, ASN213L, ASN713M, ASP161L, ASP166L, ASP206L, ASP216L, ASP40L, ASP540M, ASP602M, ASP661M, ASP666M, ASP677M, ASP706M, ASP716M, CYS148L, CYS202L, CYS648M, CYS702M, GLN133L, GLN147L, GLN149L, GLN165L, GLN168L, GLN192L, GLN215L, GLN224L, GLN42L, GLN43L, GLN542M, GLN543M, GLN633M, GLN647M, GLN649M, GLN665M, GLN668M, GLN715M, GLN724M, GLU152L, GLU163L, GLU169L, GLU182L, GLU185L, GLU186L, GLU191L, GLU200L, GLU652M, GLU663M, GLU669M, GLU682M, GLU685M, GLU686M, GLU691M, GLU696M, GLU700M, GLY141L, GLY171L, GLY205L, GLY207L, GLY641M, GLY671M, GLY705M, GLY707M, HIS134L, HIS158L, HIS225L, HIS634M, HIS658M, HIS725M, ILE136L, ILE164L, ILE175L, ILE195L, ILE204L, ILE636M, ILE664M, ILE675M, ILE704M, LEU125L, LEU130L, LEU135L, LEU139L, LEU144L, LEU146L, LEU153L, LEU156L, LEU157L, LEU162L, LEU174L, LEU179L, LEU190L, LEU198L, LEU214L, LEU217L, LEU24L, LEU41L, LEU524M, LEU541M, LEU625M, LEU630M, LEU635M, LEU639M, LEU644M, LEU646M, LEU653M, LEU656M, LEU657M, LEU662M, LEU674M, LEU679M, LEU690M, LEU698M, LEU714M, LEU717M, LYS160L, LYS180L, LYS197L, LYS208L, LYS660M, LYS680M, LYS697M, LYS708M, MET140L, MET142L, MET159L, MET194L, MET212L, MET640M, MET642M, MET659M, MET694M, MET712M, MET719M, PHE184L, PHE189L, PHE193L, PHE210L, PHE684M, PHE689M, PHE693M, PHE710M, PRO128L, PRO138L, PRO183L, PRO199L, PRO209L, PRO628M, PRO638M, PRO683M, PRO699M, PRO709M, SER127L, SER129L, SER132L, SER143L, SER170L, SER203L, SER39L, SER539M, SER629M, SER632M, SER643M, SER670M, SER703M, THR155L, THR173L, THR181L, THR222L, THR223L, THR655M, THR673M, THR681M, THR722M, THR723M, TRP513M, TRP515M, TYR167L, TYR218L, TYR667M, TYR718M, VAL131L, VAL150L, VAL211L, VAL221L, VAL44L, VAL544M, VAL631M, VAL650M, VAL711M, VAL721M
• L-O: ALA101O, ALA103O, ALA126O, ALA67L, ARG57L, ARG64L, ASP102O, ASP50L, ASP50O, CYS123O, GLN48L, GLN48O, GLN56L, GLN56O, GLN6O, GLU2O, GLU3O, GLU47O, GLU5O, GLU60L, HIS46O, LEU125O, LEU130O, LEU37O, LEU65L, LYS59L, LYS63L, MET124O, MET1L, MET1O, PRO128O, PRO68L, PRO69L, SER127O, SER129O, SER52L, SER52O, SER55L, THR51L, THR51O, THR66L, TRP45O, VAL131O, VAL44O, VAL53L, VAL53O, VAL54L
• L-Q: ALA101L, ALA103L, ALA601Q, ALA603Q, ARG107L, ARG557Q, ARG57L, ARG607Q, ASN120L, ASN620Q, ASP102L, ASP598Q, ASP602Q, ASP98L, CYS123L, CYS597Q, CYS599Q, CYS623Q, CYS97L, CYS99L, GLN43L, GLN543Q, GLU47L, GLU547Q, GLU560Q, GLU60L, HIS122L, HIS46L, HIS622Q, ILE105L, ILE605Q, LEU104L, LEU106L, LEU125L, LEU604Q, LEU606Q, LEU625Q, MET124L, MET624Q, PHE121L, PHE621Q, TRP45L, VAL100L, VAL549Q, VAL553Q, VAL600Q
• M-N: ALA570M, ALA571M, ARG107N, ASN100N, ASN112N, ASN87N, ASP550M, CYS93N, GLN532M, GLU13N, GLU502M, GLU503M, GLU91N, GLU98N, GLY533M, ILE529M, LEU10N, LEU504M, LEU573M, LYS531M, LYS90N, MET501M, PHE528M, PHE88N, PHE95N, PHE96N, PRO14N, PRO568M, PRO569M, SER105N, SER110N, SER12N, SER15N, SER552M, SER555M, SER89N, SER92N, THR530M, THR551M, THR85N, TYR94N, VAL11N
• M-Q: ALA570Q, ALA601M, ALA603M, ALA626M, ARG557Q, ASP550M, ASP550Q, ASP602M, CYS623M, GLN506M, GLN548M, GLN556Q, GLU502M, GLU505M, GLU547M, GLU560Q, HIS546M, HIS622M, LEU565Q, LEU625M, LEU630M, LYS559Q, LYS563Q, MET501M, MET501Q, MET624M, PRO568Q, PRO569Q, PRO628M, SER552M, SER552Q, SER555Q, SER627M, SER629M, THR551Q, THR566Q, TRP545M, VAL549M, VAL553M, VAL553Q, VAL554Q, VAL600M
• N-P: ALA120N, ALA135N, ALA139N, ALA620P, ALA635P, ALA639P, ARG124N, ARG150N, ARG153N, ARG507P, ARG624P, ARG650P, ARG653P, ARG7N, ASN118N, ASN137N, ASN141N, ASN148N, ASN156N, ASN618P, ASN637P, ASN641P, ASN648P, ASN656P, ASP132N, ASP154N, ASP157N, ASP38N, ASP538P, ASP632P, ASP654P, ASP657P, CYS128N, CYS130N, CYS628P, CYS630P, GLN138N, GLN145N, GLN21N, GLN521P, GLN638P, GLN645P, GLU121N, GLU125N, GLU136N, GLU142N, GLU147N, GLU149N, GLU621P, GLU625P, GLU636P, GLU642P, GLU647P, GLU649P, GLY39N, GLY539P, GLY577P, HIS143N, HIS18N, HIS40N, HIS509P, HIS518P, HIS540P, HIS643P, HIS9N, ILE123N, ILE127N, ILE134N, ILE16N, ILE505P, ILE516P, ILE5N, ILE623P, ILE627P, ILE634P, ILE8N, LEU126N, LEU131N, LEU144N, LEU151N, LEU152N, LEU20N, LEU520P, LEU626P, LEU631P, LEU644P, LEU651P, LEU652P, LYS140N, LYS146N, LYS4N, LYS504P, LYS590P, LYS640P, LYS646P, LYS90N, PHE19N, PHE519P, PRO119N, PRO619P, SER15N, SER41N, SER506P, SER515P, SER541P, SER6N, THR133N, THR17N, THR37N, THR517P, THR537P, THR633P, TRP155N, TRP655P, TYR129N, TYR629P, VAL122N, VAL622P
• N-Q: ALA567Q, ALA56N, ALA571Q, ALA60N, ARG107N, ARG564Q, ARG609Q, ASN100N, ASN562Q, ASN87N, ASP103N, ASP57N, ASP58N, ASP82N, CYS574Q, GLN54N, GLU55N, GLU611Q, GLU62N, GLU69N, GLU98N, GLY109N, GLY614Q, HIS575Q, ILE52N, LEU101N, LEU108N, LEU565Q, LEU612Q, LEU615Q, LYS102N, LYS559Q, LYS563Q, LYS65N, LYS99N, MET59N, MET61N, PHE106N, PHE572Q, PHE617Q, PHE96N, PHE97N, PRO568Q, PRO616Q, SER105N, SER110N, SER53N, SER613Q, THR566Q, TYR618Q, TYR66N, TYR84N, TYR94N, VAL104N
• O-Q: ALA126O, ALA145O, ALA154O, ALA172O, ALA201O, ALA220O, ALA626Q, ALA645Q, ALA654Q, ALA672Q, ALA701Q, ALA720Q, ARG137O, ARG151O, ARG176O, ARG178O, ARG637Q, ARG651Q, ARG676Q, ARG678Q, ASN213O, ASN713Q, ASP102O, ASP161O, ASP166O, ASP177O, ASP206O, ASP216O, ASP40O, ASP540Q, ASP661Q, ASP666Q, ASP677Q, ASP706Q, ASP716Q, CYS148O, CYS202O, CYS648Q, CYS702Q, GLN133O, GLN147O, GLN149O, GLN165O, GLN168O, GLN192O, GLN215O, GLN224O, GLN42O, GLN43O, GLN542Q, GLN543Q, GLN633Q, GLN647Q, GLN649Q, GLN665Q, GLN668Q, GLN692Q, GLN715Q, GLN724Q, GLU152O, GLU163O, GLU169O, GLU182O, GLU185O, GLU186O, GLU191O, GLU196O, GLU200O, GLU652Q, GLU663Q, GLU669Q, GLU682Q, GLU685Q, GLU686Q, GLU691Q, GLU696Q, GLU700Q, GLY141O, GLY171O, GLY205O, GLY207O, GLY641Q, GLY671Q, GLY705Q, GLY707Q, HIS134O, HIS158O, HIS225O, HIS227O, HIS634Q, HIS658Q, HIS725Q, ILE136O, ILE164O, ILE175O, ILE195O, ILE204O, ILE636Q, ILE664Q, ILE675Q, ILE695Q, ILE704Q, LEU125O, LEU130O, LEU135O, LEU139O, LEU144O, LEU146O, LEU153O, LEU156O, LEU157O, LEU162O, LEU174O, LEU179O, LEU190O, LEU198O, LEU214O, LEU217O, LEU24O, LEU41O, LEU524Q, LEU541Q, LEU625Q, LEU630Q, LEU635Q, LEU639Q, LEU644Q, LEU646Q, LEU653Q, LEU656Q, LEU657Q, LEU662Q, LEU674Q, LEU679Q, LEU690Q, LEU698Q, LEU714Q, LEU717Q, LYS160O, LYS180O, LYS197O, LYS208O, LYS660Q, LYS680Q, LYS697Q, LYS708Q, MET140O, MET142O, MET159O, MET194O, MET212O, MET219O, MET640Q, MET642Q, MET659Q, MET694Q, MET719Q, PHE184O, PHE189O, PHE193O, PHE210O, PHE684Q, PHE689Q, PHE693Q, PHE710Q, PRO128O, PRO138O, PRO183O, PRO199O, PRO209O, PRO628Q, PRO638Q, PRO683Q, PRO699Q, PRO709Q, SER129O, SER132O, SER143O, SER170O, SER188O, SER203O, SER39O, SER539Q, SER627Q, SER629Q, SER632Q, SER643Q, SER670Q, SER703Q, THR155O, THR173O, THR181O, THR222O, THR223O, THR655Q, THR673Q, THR681Q, THR722Q, THR723Q, TRP13O, TRP513Q, TRP515Q, TYR167O, TYR218O, TYR667Q, TYR718Q, VAL131O, VAL150O, VAL211O, VAL221O, VAL44O, VAL544Q, VAL631Q, VAL650Q, VAL711Q, VAL721Q
• R-V: ALA120R, ALA135R, ALA139R, ALA620V, ALA635V, ALA639V, ARG124R, ARG150R, ARG153R, ARG3R, ARG503V, ARG507V, ARG624V, ARG650V, ARG653V, ARG7R, ASN137R, ASN141R, ASN148R, ASN156R, ASN618V, ASN637V, ASN641V, ASN648V, ASN656V, ASP132R, ASP154R, ASP157R, ASP38R, ASP538V, ASP632V, ASP654V, ASP657V, CYS128R, CYS130R, CYS628V, CYS630V, GLN138R, GLN145R, GLN21R, GLN638V, GLN645V, GLU121R, GLU125R, GLU136R, GLU13R, GLU142R, GLU147R, GLU149R, GLU621V, GLU625V, GLU636V, GLU642V, GLU647V, GLU649V, GLY39R, GLY539V, HIS143R, HIS18R, HIS40R, HIS509V, HIS518V, HIS540V, HIS643V, HIS9R, ILE123R, ILE127R, ILE134R, ILE16R, ILE505V, ILE516V, ILE5R, ILE623V, ILE627V, ILE634V, ILE8R, LEU126R, LEU131R, LEU144R, LEU151R, LEU152R, LEU20R, LEU520V, LEU626V, LEU631V, LEU644V, LEU651V, LEU652V, LYS140R, LYS146R, LYS4R, LYS504V, LYS640V, LYS646V, PHE19R, PHE519V, PRO119R, PRO14R, PRO619V, SER15R, SER41R, SER506V, SER515V, SER541V, SER6R, THR133R, THR17R, THR37R, THR517V, THR537V, THR633V, TRP155R, TRP655V, TYR129R, TYR629V, VAL122R, VAL622V
• R-W: ALA567W, ALA56R, ALA570W, ALA571W, ALA60R, ARG107R, ARG564W, ARG609W, ASN100R, ASN562W, ASP103R, ASP57R, ASP58R, CYS574W, GLN54R, GLU51R, GLU55R, GLU611W, GLU62R, GLU69R, GLU98R, GLY109R, GLY614W, HIS575W, ILE52R, LEU101R, LEU108R, LEU565W, LEU576W, LEU579W, LEU612W, LEU615W, LEU70R, LYS102R, LYS559W, LYS563W, LYS65R, LYS99R, MET59R, MET61R, PHE106R, PHE572W, PHE617W, PHE96R, PHE97R, PRO568W, PRO616W, SER105R, SER110R, SER613W, THR566W, TYR618W, TYR66R, TYR84R, TYR94R, VAL104R
• S-W: ALA126S, ALA145S, ALA154S, ALA172S, ALA201S, ALA220S, ALA626W, ALA645W, ALA654W, ALA672W, ALA701W, ALA720W, ARG137S, ARG151S, ARG176S, ARG178S, ARG637W, ARG651W, ARG676W, ARG678W, ASN213S, ASN713W, ASP102S, ASP161S, ASP166S, ASP177S, ASP206S, ASP216S, ASP40S, ASP540W, ASP602W, ASP661W, ASP666W, ASP677W, ASP706W, ASP716W, CYS148S, CYS202S, CYS648W, CYS702W, GLN133S, GLN147S, GLN149S, GLN165S, GLN168S, GLN192S, GLN215S, GLN224S, GLN42S, GLN43S, GLN542W, GLN543W, GLN633W, GLN647W, GLN649W, GLN665W, GLN668W, GLN692W, GLN715W, GLN724W, GLU152S, GLU163S, GLU169S, GLU182S, GLU185S, GLU186S, GLU191S, GLU200S, GLU652W, GLU663W, GLU669W, GLU682W, GLU685W, GLU686W, GLU696W, GLU700W, GLY141S, GLY171S, GLY205S, GLY207S, GLY641W, GLY671W, GLY705W, GLY707W, HIS134S, HIS158S, HIS225S, HIS634W, HIS658W, HIS725W, HIS726W, ILE136S, ILE164S, ILE175S, ILE195S, ILE204S, ILE636W, ILE664W, ILE675W, ILE695W, ILE704W, LEU125S, LEU130S, LEU135S, LEU139S, LEU144S, LEU146S, LEU153S, LEU156S, LEU157S, LEU162S, LEU174S, LEU179S, LEU190S, LEU198S, LEU214S, LEU217S, LEU24S, LEU41S, LEU524W, LEU541W, LEU625W, LEU630W, LEU635W, LEU639W, LEU644W, LEU646W, LEU653W, LEU656W, LEU657W, LEU662W, LEU674W, LEU679W, LEU690W, LEU698W, LEU714W, LEU717W, LYS160S, LYS180S, LYS197S, LYS208S, LYS660W, LYS680W, LYS697W, LYS708W, MET140S, MET142S, MET159S, MET194S, MET212S, MET219S, MET640W, MET642W, MET659W, MET694W, MET712W, MET719W, PHE184S, PHE189S, PHE193S, PHE210S, PHE684W, PHE689W, PHE693W, PHE710W, PRO128S, PRO138S, PRO183S, PRO199S, PRO209S, PRO628W, PRO638W, PRO683W, PRO699W, PRO709W, SER127S, SER129S, SER132S, SER143S, SER170S, SER203S, SER39S, SER539W, SER627W, SER629W, SER632W, SER643W, SER670W, SER703W, THR155S, THR173S, THR181S, THR222S, THR223S, THR655W, THR673W, THR681W, THR722W, THR723W, TRP513W, TRP515W, TYR167S, TYR218S, TYR667W, TYR718W, VAL131S, VAL150S, VAL211S, VAL221S, VAL44S, VAL544W, VAL631W, VAL650W, VAL711W, VAL721W
• T-X: ALA126T, ALA145T, ALA154T, ALA172T, ALA201T, ALA220T, ALA626X, ALA645X, ALA654X, ALA672X, ALA701X, ALA720X, ARG137T, ARG151T, ARG176T, ARG178T, ARG637X, ARG651X, ARG676X, ARG678X, ASN187T, ASN213T, ASN687X, ASN713X, ASP161T, ASP166T, ASP177T, ASP206T, ASP216T, ASP40T, ASP540X, ASP661X, ASP666X, ASP677X, ASP706X, ASP716X, CYS148T, CYS202T, CYS648X, CYS702X, GLN133T, GLN147T, GLN149T, GLN165T, GLN168T, GLN192T, GLN215T, GLN224T, GLN42T, GLN43T, GLN542X, GLN543X, GLN633X, GLN647X, GLN649X, GLN665X, GLN668X, GLN692X, GLN715X, GLN724X, GLU152T, GLU163T, GLU169T, GLU182T, GLU185T, GLU186T, GLU196T, GLU200T, GLU652X, GLU663X, GLU669X, GLU682X, GLU685X, GLU686X, GLU691X, GLU696X, GLU700X, GLY141T, GLY171T, GLY205T, GLY207T, GLY641X, GLY671X, GLY705X, GLY707X, HIS134T, HIS158T, HIS225T, HIS227T, HIS634X, HIS658X, HIS725X, HIS727X, ILE136T, ILE164T, ILE175T, ILE195T, ILE204T, ILE636X, ILE664X, ILE675X, ILE695X, ILE704X, LEU125T, LEU130T, LEU135T, LEU139T, LEU144T, LEU146T, LEU153T, LEU156T, LEU157T, LEU162T, LEU174T, LEU179T, LEU190T, LEU198T, LEU214T, LEU217T, LEU24T, LEU41T, LEU524X, LEU541X, LEU625X, LEU630X, LEU635X, LEU639X, LEU644X, LEU646X, LEU653X, LEU656X, LEU657X, LEU662X, LEU674X, LEU679X, LEU690X, LEU698X, LEU714X, LEU717X, LYS160T, LYS180T, LYS197T, LYS208T, LYS660X, LYS680X, LYS697X, LYS708X, MET140T, MET142T, MET159T, MET194T, MET212T, MET219T, MET640X, MET642X, MET659X, MET694X, MET712X, MET719X, PHE184T, PHE189T, PHE193T, PHE210T, PHE684X, PHE689X, PHE693X, PHE710X, PRO128T, PRO138T, PRO183T, PRO199T, PRO209T, PRO628X, PRO638X, PRO683X, PRO699X, PRO709X, SER127T, SER129T, SER132T, SER143T, SER170T, SER203T, SER39T, SER539X, SER627X, SER629X, SER632X, SER643X, SER670X, SER703X, THR155T, THR173T, THR181T, THR222T, THR223T, THR655X, THR673X, THR681X, THR722X, THR723X, TRP13T, TRP513X, TYR167T, TYR218T, TYR667X, TYR718X, VAL131T, VAL150T, VAL211T, VAL221T, VAL44T, VAL544X, VAL631X, VAL650X, VAL711X, VAL721X
• U-Y: ALA120U, ALA135U, ALA139U, ALA620Y, ALA635Y, ALA639Y, ARG124U, ARG150U, ARG153U, ARG507Y, ARG624Y, ARG650Y, ARG653Y, ARG7U, ASN118U, ASN137U, ASN141U, ASN148U, ASN156U, ASN618Y, ASN637Y, ASN641Y, ASN648Y, ASP132U, ASP154U, ASP157U, ASP38U, ASP538Y, ASP632Y, ASP654Y, ASP657Y, CYS128U, CYS130U, CYS628Y, CYS630Y, GLN138U, GLN145U, GLN21U, GLN638Y, GLN645Y, GLU121U, GLU125U, GLU136U, GLU142U, GLU147U, GLU149U, GLU621Y, GLU625Y, GLU636Y, GLU642Y, GLU647Y, GLU649Y, GLY39U, GLY539Y, GLY577Y, HIS143U, HIS18U, HIS40U, HIS518Y, HIS540Y, HIS643Y, HIS9U, ILE123U, ILE127U, ILE134U, ILE16U, ILE505Y, ILE508Y, ILE516Y, ILE5U, ILE623Y, ILE627Y, ILE634Y, ILE8U, LEU126U, LEU131U, LEU144U, LEU151U, LEU152U, LEU20U, LEU520Y, LEU626Y, LEU631Y, LEU644Y, LEU651Y, LEU652Y, LYS140U, LYS146U, LYS4U, LYS504Y, LYS590Y, LYS640Y, LYS646Y, PHE19U, PHE519Y, PRO119U, PRO619Y, SER15U, SER41U, SER506Y, SER515Y, SER541Y, SER576Y, SER6U, SER76U, THR133U, THR17U, THR37U, THR517Y, THR537Y, THR633Y, TRP155U, TRP655Y, TYR129U, TYR629Y, VAL122U, VAL622Y