3RRR

structure of the rsv f protein in the post-fusion conformation

• Total interactions analyzed: 66
• Total true interactions: 33
• Strongest Interaction:
  • Chains: C-F
  • Int. Res.: 120
  • Norm. En. per Res.: -3.606
• Hub Node: B(8)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-262.4797	-46.1379	491.024	182.4064	236	84	34	38572	3	30	29
A-D	-67.7139	14.7883	-360.857	-413.7826	126	29	6	14474	0	18	17
A-F	0.0	0.0	-19.4307	-19.4307	15	0	0	582	0	2	1
B-C	0.0	1.1133	-17.1205	-16.0072	15	0	0	695	0	2	1
B-D	-62.2532	-75.8968	-959.963	-1098.1131	394	69	53	45304	8	61	53
B-E	-102.5396	12.0062	-360.073	-450.6063	125	18	5	13875	2	17	17
B-F	-75.1903	-42.9832	-925.058	-1043.2316	385	74	51	44718	6	61	54
B-H	-12.6115	-61.0044	-53.1592	-126.7751	43	14	0	2322	3	9	7
B-I	0.0	0.0	-0.0267	-0.0267	4	0	0	14	0	2	0
B-M	-6.3337	-0.345	-26.2736	-32.9523	17	1	0	1170	0	4	4
B-N	-8.405	4.1543	-5.6498	-9.9005	9	1	0	378	0	0	4
C-D	-278.4081	-38.6608	548.491	231.4221	232	81	35	37731	2	31	28
C-F	-85.5895	13.0125	-360.146	-432.723	120	27	5	14316	1	18	17
C-H	-7.2398	-2.9662	-30.8982	-41.1042	17	4	0	1219	0	4	6
C-L	0.0	0.0	-0.0044	-0.0044	2	0	0	5	0	1	0
D-E	0.0	0.0	-5.5043	-5.5043	12	0	0	491	0	2	1
D-F	-85.6206	-58.0632	-946.454	-1090.1378	391	79	55	44667	6	60	52
D-H	0.0	2.4329	-4.6577	-2.2248	11	0	0	265	0	0	4
E-F	-274.7207	-40.4151	545.077	229.9411	236	73	33	38410	2	30	28
E-H	0.0	0.0	-0.0354	-0.0354	4	0	0	13	0	2	0
F-M	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	1	0
G-H	-243.4295	-40.1018	586.143	302.6117	234	88	35	37969	2	29	30
G-L	0.0	0.0	-4.9872	-4.9872	12	0	0	396	0	2	1
G-N	-66.6403	20.4133	-327.572	-373.799	122	19	5	13710	0	18	17
H-I	-81.7845	14.8922	-370.591	-437.4833	122	14	6	14223	1	18	18
H-L	-65.0611	-69.3366	-932.989	-1067.3867	387	62	56	45059	8	60	56
H-M	0.0	3.6772	-15.4665	-11.7893	17	0	0	660	0	2	1
H-N	-72.3519	-63.523	-967.15	-1103.0248	396	76	54	45575	6	61	52
I-L	-260.8836	-50.2922	501.875	190.6992	233	72	37	38025	3	30	30
I-N	0.0	0.0	-5.032	-5.032	15	0	0	377	0	2	1
L-M	-96.3539	10.8641	-364.172	-449.6618	131	24	5	14590	1	19	16
L-N	-42.2948	-45.0751	-956.103	-1043.4728	388	66	51	44524	4	60	52
M-N	-244.7339	-49.1056	561.672	267.8325	229	80	33	37621	2	28	31

Interface residues

• A-B: ALA241B, ALA298B, ALA346B, ALA39A, ALA412B, ALA47A, ALA74A, ALA89A, ARG229B, ARG235B, ARG282B, ARG336B, ARG339B, ARG364B, ARG49A, ASN208B, ASN216B, ASN227B, ASN228B, ASN240B, ASN262B, ASN277B, ASN27A, ASN345B, ASN363B, ASN371B, ASN380B, ASN383B, ASN388B, ASN437B, ASN444B, ASN63A, ASN67A, ASN70A, ASN88A, ASP263B, ASP310B, ASP338B, ASP344B, ASP368B, ASP385B, ASP440B, ASP73A, CYS212B, CYS313B, CYS322B, CYS343B, CYS358B, CYS367B, CYS37A, CYS382B, CYS393B, CYS416B, CYS439B, CYS69A, GLN210B, GLN224B, GLN225B, GLN26A, GLN270B, GLN283B, GLN284B, GLN302B, GLN34A, GLN361B, GLN81A, GLN94A, GLN98A, GLU218B, GLU222B, GLU236B, GLU256B, GLU294B, GLU295B, GLU30A, GLU31A, GLU60A, GLU66A, GLU82A, GLU92A, GLY242B, GLY307B, GLY340B, GLY411B, GLY438B, GLY43A, GLY51A, GLY71A, HIS317B, ILE206B, ILE214B, ILE217B, ILE221B, ILE233B, ILE261B, ILE266B, ILE280B, ILE288B, ILE28A, ILE291B, ILE292B, ILE309B, ILE386B, ILE395B, ILE407B, ILE413B, ILE57A, ILE59A, ILE64A, ILE79A, LEU230B, LEU231B, LEU252B, LEU257B, LEU260B, LEU273B, LEU297B, LEU303B, LEU305B, LEU316B, LEU321B, LEU334B, LEU381B, LEU410B, LEU45A, LEU48A, LEU61A, LEU78A, LEU83A, LEU93A, LEU95A, LEU96A, LYS209B, LYS226B, LYS293B, LYS315B, LYS359B, LYS42A, LYS445B, LYS65A, LYS68A, LYS77A, LYS80A, LYS85A, LYS87A, MET251B, MET264B, MET274B, MET289B, MET370B, MET97A, PHE223B, PHE237B, PHE32A, PHE351B, PHE352B, PHE366B, PHE387B, PRO205B, PRO265B, PRO304B, PRO312B, PRO320B, SER211B, SER213B, SER215B, SER238B, SER259B, SER285B, SER287B, SER290B, SER319B, SER350B, SER35A, SER362B, SER372B, SER38A, SER409B, SER415B, SER41A, SER443B, SER46A, SER55A, SER62A, THR219B, THR234B, THR245B, THR253B, THR29A, THR311B, THR318B, THR335B, THR357B, THR369B, THR36A, THR408B, THR50A, THR54A, THR58A, THR72A, THR91A, TRP314B, TRP341B, TRP52A, TYR250B, TYR286B, TYR299B, TYR306B, TYR33A, TYR342B, TYR417B, TYR441B, TYR44A, TYR53A, TYR86A, VAL207B, VAL220B, VAL239B, VAL243B, VAL247B, VAL281B, VAL296B, VAL300B, VAL301B, VAL308B, VAL349B, VAL360B, VAL365B, VAL384B, VAL406B, VAL40A, VAL414B, VAL442B, VAL56A, VAL76A, VAL90A
• A-D: ALA74A, ALA89A, ARG229D, ARG282D, ARG49A, ASN227D, ASN228D, ASN254D, ASN276D, ASN277D, ASN460D, ASN476D, ASN63A, ASN67A, ASN70A, ASN88A, ASP73A, ASP84A, CYS212D, CYS69A, GLN210D, GLN224D, GLN225D, GLN279D, GLN283D, GLN361D, GLN462D, GLN81A, GLN94A, GLN98A, GLU218D, GLU222D, GLU232D, GLU256D, GLU463D, GLU472D, GLU60A, GLU66A, GLU82A, GLU92A, GLY464D, GLY471D, GLY51A, GLY71A, ILE214D, ILE217D, ILE221D, ILE280D, ILE407D, ILE474D, ILE475D, ILE57A, ILE59A, ILE64A, ILE79A, LEU231D, LEU252D, LEU257D, LEU258D, LEU273D, LEU456D, LEU467D, LEU48A, LEU61A, LEU78A, LEU83A, LEU93A, LEU95A, LEU96A, LYS226D, LYS461D, LYS465D, LYS470D, LYS65A, LYS68A, LYS75A, LYS77A, LYS80A, LYS85A, MET274D, MET97A, PHE223D, PHE477D, PRO246D, PRO473D, PRO480D, SER211D, SER215D, SER248D, SER255D, SER275D, SER362D, SER405D, SER466D, SER55A, SER62A, THR219D, THR249D, THR253D, THR449D, THR455D, THR50A, THR54A, THR58A, THR72A, THR91A, TRP52A, TYR250D, TYR457D, TYR458D, TYR468D, TYR478D, TYR53A, TYR86A, VAL207D, VAL220D, VAL247D, VAL278D, VAL281D, VAL450D, VAL452D, VAL459D, VAL469D, VAL56A, VAL76A, VAL90A
• A-F: ALA74A, ASN476F, ASP479F, ASP73A, GLN81A, GLY71A, ILE217F, ILE474F, ILE475F, LEU78A, LYS75A, PHE477F, THR72A, TYR478F, VAL76A
• B-C: ALA74C, ASN476B, ASP479B, ASP73C, GLN81C, GLY71C, ILE217B, ILE474B, ILE475B, LEU78C, LYS75C, PHE477B, THR72C, TYR478B, VAL76C
• B-D: ALA149B, ALA153B, ALA153D, ALA170B, ALA170D, ALA177B, ALA177D, ALA241B, ALA298B, ALA346B, ALA355D, ALA490B, ALA490D, ALA504B, ALA504D, ARG229B, ARG235B, ARG235D, ARG282D, ARG336D, ARG339D, ARG507B, ARG507D, ASN165D, ASN175B, ASN175D, ASN183B, ASN183D, ASN197B, ASN197D, ASN208B, ASN208D, ASN216B, ASN216D, ASN227B, ASN228D, ASN240B, ASN240D, ASN262B, ASN345B, ASN371B, ASN388B, ASN454D, ASN460D, ASN476D, ASN496B, ASN496D, ASN500B, ASN500D, ASP194B, ASP194D, ASP200B, ASP200D, ASP263B, ASP338D, ASP344B, ASP392B, ASP401D, ASP479B, ASP479D, ASP486D, ASP489B, ASP489D, ASP510B, ASP510D, CYS212B, CYS212D, CYS333D, CYS393B, CYS422D, GLN202B, GLN202D, GLN210B, GLN210D, GLN224B, GLN224D, GLN225B, GLN225D, GLN270B, GLN279D, GLN283D, GLN284D, GLN302B, GLN354B, GLN354D, GLN462D, GLN494B, GLN494D, GLN501B, GLN501D, GLU161B, GLU161D, GLU163B, GLU163D, GLU218B, GLU218D, GLU222B, GLU222D, GLU232B, GLU232D, GLU236B, GLU236D, GLU256B, GLU295B, GLU356B, GLU356D, GLU378B, GLU463D, GLU472D, GLU487B, GLU487D, GLU497B, GLU497D, GLU511B, GLU511D, GLY151B, GLY162B, GLY162D, GLY184B, GLY184D, GLY242B, GLY307B, GLY340D, GLY347B, GLY453D, GLY464D, GLY471D, GLY514B, GLY514D, HIS159B, HIS159D, HIS317D, ILE167B, ILE167D, ILE199B, ILE199D, ILE206B, ILE206D, ILE214B, ILE214D, ILE217B, ILE217D, ILE221B, ILE221D, ILE233B, ILE233D, ILE261B, ILE266B, ILE280D, ILE288B, ILE309B, ILE407D, ILE474D, ILE475D, ILE492B, ILE492D, ILE499B, ILE499D, ILE506B, ILE506D, LEU158B, LEU158D, LEU160B, LEU160D, LEU171B, LEU171D, LEU172B, LEU172D, LEU181B, LEU181D, LEU188B, LEU188D, LEU193B, LEU193D, LEU195B, LEU195D, LEU203B, LEU203D, LEU204B, LEU204D, LEU230B, LEU231B, LEU231D, LEU252B, LEU252D, LEU257B, LEU258B, LEU260B, LEU297B, LEU303B, LEU305B, LEU373B, LEU375B, LEU381B, LEU456D, LEU467D, LEU481B, LEU481D, LEU503B, LEU503D, LEU512B, LEU512D, LEU513B, LEU513D, LYS156B, LYS156D, LYS166B, LYS166D, LYS168B, LYS168D, LYS176B, LYS176D, LYS191B, LYS191D, LYS196B, LYS196D, LYS201B, LYS201D, LYS209B, LYS209D, LYS226B, LYS315D, LYS390B, LYS394B, LYS394D, LYS399D, LYS421D, LYS427D, LYS461D, LYS465D, LYS470D, LYS498B, LYS498D, LYS508B, LYS508D, MET251B, MET251D, MET264B, MET289B, MET370B, MET396D, PHE223B, PHE237B, PHE351B, PHE352B, PHE387B, PHE477B, PHE477D, PHE483B, PHE483D, PHE488B, PHE488D, PHE505B, PHE505D, PRO205B, PRO205D, PRO246D, PRO265B, PRO320D, PRO353D, PRO376B, PRO389B, PRO473D, PRO480B, PRO480D, PRO484B, PRO484D, SER155B, SER155D, SER169B, SER169D, SER173B, SER173D, SER180B, SER180D, SER182B, SER182D, SER186B, SER186D, SER190B, SER190D, SER211B, SER211D, SER213B, SER213D, SER215B, SER215D, SER238B, SER248D, SER255B, SER259B, SER287B, SER290B, SER319D, SER348B, SER350B, SER372B, SER377B, SER398D, SER403D, SER404D, SER405D, SER415D, SER451D, SER466D, SER485D, SER491B, SER491D, SER493B, SER493D, SER502B, SER502D, SER509B, SER509D, THR174B, THR174D, THR189B, THR189D, THR219B, THR219D, THR234B, THR244B, THR244D, THR245B, THR245D, THR249D, THR253B, THR267B, THR311B, THR318D, THR335D, THR337D, THR369B, THR374B, THR397D, THR400D, THR408D, THR420D, THR449D, THR455D, TYR198B, TYR198D, TYR250B, TYR250D, TYR286B, TYR299B, TYR306B, TYR391B, TYR417D, TYR457D, TYR458D, TYR468D, TYR478B, TYR478D, VAL152B, VAL152D, VAL154B, VAL154D, VAL157B, VAL157D, VAL164B, VAL164D, VAL178B, VAL178D, VAL179B, VAL179D, VAL185B, VAL185D, VAL187B, VAL187D, VAL192B, VAL192D, VAL207B, VAL207D, VAL220B, VAL239B, VAL239D, VAL243B, VAL247D, VAL278D, VAL296B, VAL300B, VAL301B, VAL308B, VAL349B, VAL379B, VAL402D, VAL406D, VAL452D, VAL469D, VAL482B, VAL482D, VAL495B, VAL495D
• B-E: ALA74E, ALA89E, ARG229B, ARG235B, ARG282B, ARG49E, ASN216B, ASN227B, ASN228B, ASN254B, ASN276B, ASN277B, ASN460B, ASN476B, ASN63E, ASN67E, ASN70E, ASN88E, ASP73E, ASP84E, CYS212B, CYS69E, GLN210B, GLN224B, GLN225B, GLN279B, GLN283B, GLN361B, GLN462B, GLN81E, GLN94E, GLN98E, GLU218B, GLU222B, GLU232B, GLU256B, GLU463B, GLU472B, GLU60E, GLU66E, GLU82E, GLU92E, GLY464B, GLY471B, GLY51E, GLY71E, ILE214B, ILE217B, ILE221B, ILE280B, ILE407B, ILE474B, ILE475B, ILE57E, ILE59E, ILE64E, ILE79E, LEU231B, LEU252B, LEU257B, LEU258B, LEU456B, LEU467B, LEU48E, LEU61E, LEU78E, LEU83E, LEU93E, LEU95E, LEU96E, LYS226B, LYS461B, LYS465B, LYS470B, LYS65E, LYS68E, LYS75E, LYS77E, LYS80E, LYS85E, MET274B, MET97E, PHE223B, PHE477B, PRO246B, PRO473B, PRO480B, SER211B, SER213B, SER215B, SER248B, SER255B, SER275B, SER362B, SER405B, SER466B, SER55E, SER62E, THR219B, THR249B, THR253B, THR455B, THR50E, THR54E, THR58E, THR72E, THR91E, TRP52E, TYR250B, TYR457B, TYR458B, TYR468B, TYR478B, TYR53E, TYR86E, VAL220B, VAL247B, VAL278B, VAL406B, VAL450B, VAL459B, VAL469B, VAL56E, VAL76E, VAL90E
• B-F: ALA147B, ALA149B, ALA153B, ALA170B, ALA170F, ALA177B, ALA177F, ALA241F, ALA298F, ALA346F, ALA355B, ALA490B, ALA490F, ALA504B, ALA504F, ARG229F, ARG235B, ARG235F, ARG282B, ARG336B, ARG339B, ARG507B, ARG507F, ASN165B, ASN165F, ASN175B, ASN175F, ASN183B, ASN183F, ASN197B, ASN197F, ASN208B, ASN208F, ASN216B, ASN216F, ASN227F, ASN228B, ASN240B, ASN240F, ASN262F, ASN345F, ASN371F, ASN388F, ASN454B, ASN460B, ASN476B, ASN496B, ASN496F, ASN500B, ASN500F, ASP194B, ASP194F, ASP200B, ASP200F, ASP263F, ASP344F, ASP392F, ASP401B, ASP479B, ASP479F, ASP486B, ASP489B, ASP489F, ASP510B, ASP510F, CYS212B, CYS212F, CYS333B, CYS393F, CYS422B, GLN202B, GLN202F, GLN210B, GLN210F, GLN224B, GLN224F, GLN225B, GLN225F, GLN270F, GLN279B, GLN283B, GLN284B, GLN302F, GLN354B, GLN354F, GLN462B, GLN494B, GLN494F, GLN501F, GLU161B, GLU161F, GLU163B, GLU163F, GLU218B, GLU218F, GLU222B, GLU222F, GLU232B, GLU232F, GLU236B, GLU236F, GLU256F, GLU295F, GLU356B, GLU356F, GLU378F, GLU463B, GLU472B, GLU487B, GLU487F, GLU497B, GLU497F, GLU511B, GLU511F, GLY162B, GLY162F, GLY184B, GLY184F, GLY242F, GLY307F, GLY340B, GLY347F, GLY453B, GLY464B, GLY471B, GLY514B, GLY514F, HIS159B, HIS159F, HIS317B, ILE148B, ILE167B, ILE167F, ILE199B, ILE199F, ILE206B, ILE206F, ILE214B, ILE214F, ILE217B, ILE217F, ILE221B, ILE221F, ILE233B, ILE233F, ILE261F, ILE266F, ILE280B, ILE288F, ILE309F, ILE407B, ILE474B, ILE475B, ILE492B, ILE492F, ILE499B, ILE499F, ILE506B, ILE506F, LEU158B, LEU158F, LEU160B, LEU160F, LEU171B, LEU171F, LEU172B, LEU172F, LEU181B, LEU181F, LEU188B, LEU188F, LEU193B, LEU193F, LEU195B, LEU195F, LEU203B, LEU203F, LEU204B, LEU204F, LEU230F, LEU231B, LEU231F, LEU252B, LEU252F, LEU257F, LEU258F, LEU260F, LEU297F, LEU303F, LEU305F, LEU373F, LEU375F, LEU456B, LEU467B, LEU481B, LEU481F, LEU503B, LEU503F, LEU512B, LEU512F, LEU513B, LEU513F, LYS156B, LYS156F, LYS166B, LYS166F, LYS168B, LYS168F, LYS176B, LYS176F, LYS191B, LYS191F, LYS196B, LYS196F, LYS201F, LYS209B, LYS209F, LYS226F, LYS315B, LYS390F, LYS394F, LYS399B, LYS421B, LYS461B, LYS465B, LYS470B, LYS498B, LYS498F, LYS508B, LYS508F, MET251B, MET251F, MET264F, MET289F, MET370F, MET396B, PHE223F, PHE237F, PHE351F, PHE387F, PHE477B, PHE477F, PHE483B, PHE483F, PHE488B, PHE488F, PHE505B, PHE505F, PRO205B, PRO205F, PRO246B, PRO265F, PRO304F, PRO320B, PRO353B, PRO353F, PRO376F, PRO389F, PRO473B, PRO480B, PRO480F, PRO484B, PRO484F, SER155F, SER169B, SER169F, SER173B, SER173F, SER180B, SER180F, SER182B, SER182F, SER186B, SER186F, SER190B, SER190F, SER211B, SER211F, SER213B, SER213F, SER215B, SER215F, SER238F, SER248B, SER255F, SER259F, SER319B, SER348F, SER350F, SER372F, SER377F, SER398B, SER403B, SER404B, SER405B, SER415B, SER451B, SER466B, SER485B, SER485F, SER491B, SER491F, SER493B, SER493F, SER502B, SER502F, SER509B, SER509F, THR174B, THR174F, THR189B, THR189F, THR219B, THR219F, THR234F, THR244B, THR244F, THR245B, THR249B, THR253F, THR267F, THR311F, THR318B, THR335B, THR337B, THR357F, THR369F, THR374F, THR397B, THR400B, THR408B, THR420B, THR455B, TYR198B, TYR198F, TYR250B, TYR250F, TYR286F, TYR299F, TYR306F, TYR391F, TYR417B, TYR457B, TYR458B, TYR468B, TYR478B, TYR478F, VAL152B, VAL154B, VAL157B, VAL157F, VAL164B, VAL164F, VAL178B, VAL178F, VAL179B, VAL179F, VAL185B, VAL185F, VAL187B, VAL187F, VAL192B, VAL192F, VAL207B, VAL207F, VAL220F, VAL239B, VAL239F, VAL243F, VAL247B, VAL278B, VAL296F, VAL300F, VAL301F, VAL308F, VAL349F, VAL379F, VAL402B, VAL406B, VAL452B, VAL469B, VAL482B, VAL482F, VAL495B, VAL495F
• B-H: ARG429B, ARG429H, ASN426B, ASN426H, ASN428B, ASN428H, ASN476B, ASN476H, ASP479B, ASP479H, GLU463B, GLU463H, GLU472B, GLU472H, GLY430H, GLY464B, GLY464H, GLY471B, GLY471H, ILE432B, ILE432H, ILE475B, ILE475H, LEU467B, LEU467H, LEU481H, LYS427B, LYS427H, LYS465B, LYS465H, LYS470B, LYS470H, PHE477B, PHE477H, PRO480B, PRO480H, SER466B, SER466H, TYR468B, TYR468H, TYR478B, TYR478H, VAL482H
• B-I: GLU60I, LYS470B, THR58I, TYR468B
• B-M: ALA74M, ARG429B, ASN426B, ASN428B, ASN70M, ASP448B, ASP73M, GLN462B, GLU463B, GLY430B, GLY71M, ILE431B, LYS427B, LYS75M, LYS77M, THR72M, VAL76M
• B-N: ARG429B, ASN426B, ASN428B, GLN202N, GLY430B, ILE206N, ILE431B, ILE432B, LYS209N
• C-D: ALA241D, ALA298D, ALA346D, ALA39C, ALA412D, ALA47C, ALA74C, ALA89C, ARG229D, ARG235D, ARG282D, ARG336D, ARG339D, ARG364D, ARG49C, ASN208D, ASN216D, ASN227D, ASN228D, ASN240D, ASN262D, ASN277D, ASN27C, ASN345D, ASN363D, ASN371D, ASN380D, ASN383D, ASN444D, ASN63C, ASN67C, ASN70C, ASN88C, ASP263D, ASP310D, ASP344D, ASP368D, ASP385D, ASP440D, ASP73C, ASP84C, CYS212D, CYS313D, CYS322D, CYS343D, CYS358D, CYS367D, CYS37C, CYS382D, CYS393D, CYS416D, CYS439D, CYS69C, GLN210D, GLN224D, GLN225D, GLN26C, GLN270D, GLN283D, GLN284D, GLN302D, GLN34C, GLN361D, GLN81C, GLN94C, GLU218D, GLU222D, GLU232D, GLU236D, GLU256D, GLU294D, GLU295D, GLU30C, GLU31C, GLU60C, GLU66C, GLU82C, GLU92C, GLY242D, GLY307D, GLY340D, GLY411D, GLY438D, GLY43C, GLY51C, GLY71C, HIS317D, ILE206D, ILE214D, ILE217D, ILE221D, ILE233D, ILE261D, ILE266D, ILE280D, ILE288D, ILE28C, ILE291D, ILE292D, ILE309D, ILE386D, ILE395D, ILE407D, ILE413D, ILE57C, ILE59C, ILE64C, ILE79C, LEU230D, LEU231D, LEU252D, LEU257D, LEU260D, LEU273D, LEU297D, LEU303D, LEU305D, LEU316D, LEU321D, LEU334D, LEU381D, LEU410D, LEU45C, LEU48C, LEU61C, LEU78C, LEU83C, LEU93C, LEU95C, LEU96C, LYS209D, LYS226D, LYS293D, LYS315D, LYS359D, LYS42C, LYS445D, LYS65C, LYS68C, LYS77C, LYS80C, LYS85C, LYS87C, MET251D, MET264D, MET274D, MET289D, MET370D, MET97C, PHE223D, PHE237D, PHE32C, PHE352D, PHE366D, PHE387D, PRO205D, PRO265D, PRO304D, PRO312D, PRO320D, SER211D, SER213D, SER215D, SER238D, SER259D, SER285D, SER287D, SER290D, SER319D, SER350D, SER35C, SER362D, SER372D, SER38C, SER409D, SER415D, SER41C, SER443D, SER46C, SER55C, SER62C, THR219D, THR234D, THR245D, THR253D, THR29C, THR311D, THR318D, THR335D, THR357D, THR369D, THR36C, THR408D, THR50C, THR54C, THR58C, THR72C, THR91C, TRP314D, TRP341D, TRP52C, TYR250D, TYR286D, TYR299D, TYR306D, TYR33C, TYR342D, TYR417D, TYR441D, TYR44C, TYR53C, TYR86C, VAL220D, VAL239D, VAL243D, VAL247D, VAL281D, VAL296D, VAL300D, VAL301D, VAL308D, VAL349D, VAL360D, VAL365D, VAL384D, VAL406D, VAL40C, VAL414D, VAL442D, VAL56C, VAL76C, VAL90C
• C-F: ALA74C, ALA89C, ARG229F, ARG235F, ARG282F, ARG49C, ASN216F, ASN227F, ASN228F, ASN254F, ASN276F, ASN277F, ASN460F, ASN476F, ASN63C, ASN67C, ASN70C, ASN88C, ASP73C, ASP84C, CYS212F, CYS69C, GLN210F, GLN224F, GLN225F, GLN279F, GLN283F, GLN361F, GLN462F, GLN81C, GLN94C, GLU218F, GLU222F, GLU232F, GLU256F, GLU463F, GLU472F, GLU60C, GLU66C, GLU82C, GLU92C, GLY464F, GLY471F, GLY51C, GLY71C, ILE214F, ILE217F, ILE221F, ILE280F, ILE407F, ILE474F, ILE475F, ILE57C, ILE59C, ILE64C, ILE79C, LEU231F, LEU252F, LEU257F, LEU258F, LEU456F, LEU467F, LEU48C, LEU61C, LEU78C, LEU83C, LEU93C, LEU95C, LEU96C, LYS226F, LYS461F, LYS465F, LYS470F, LYS65C, LYS68C, LYS75C, LYS77C, LYS80C, LYS85C, MET97C, PHE223F, PHE477F, PRO473F, PRO480F, SER211F, SER215F, SER248F, SER255F, SER405F, SER466F, SER55C, SER62C, THR219F, THR249F, THR253F, THR449F, THR455F, THR50C, THR54C, THR58C, THR72C, THR91C, TRP52C, TYR250F, TYR457F, TYR458F, TYR468F, TYR478F, TYR53C, TYR86C, VAL220F, VAL247F, VAL278F, VAL281F, VAL450F, VAL452F, VAL459F, VAL469F, VAL56C, VAL76C
• C-H: ALA74C, ARG429H, ASN426H, ASN428H, ASN70C, ASP448H, ASP73C, GLN462H, GLU463H, GLY430H, GLY71C, ILE431H, LYS427H, LYS75C, LYS77C, THR72C, VAL76C
• C-L: LYS75C, PRO265L
• D-E: ALA74E, ASN476D, ASP479D, ASP73E, GLN81E, ILE474D, ILE475D, LYS75E, PHE477D, THR72E, TYR478D, VAL76E
• D-F: ALA153D, ALA170D, ALA170F, ALA177D, ALA177F, ALA241D, ALA298D, ALA346D, ALA355F, ALA490D, ALA490F, ALA504D, ALA504F, ARG229D, ARG235D, ARG235F, ARG282F, ARG336F, ARG339F, ARG507D, ARG507F, ASN165D, ASN165F, ASN175D, ASN175F, ASN183D, ASN183F, ASN197D, ASN197F, ASN208D, ASN208F, ASN216D, ASN216F, ASN227D, ASN228F, ASN240D, ASN240F, ASN262D, ASN345D, ASN371D, ASN388D, ASN454F, ASN460F, ASN476F, ASN496D, ASN496F, ASN500D, ASN500F, ASP194D, ASP194F, ASP200D, ASP200F, ASP263D, ASP338F, ASP344D, ASP392D, ASP401F, ASP479D, ASP479F, ASP486D, ASP486F, ASP489D, ASP489F, ASP510D, ASP510F, CYS212D, CYS212F, CYS333F, CYS393D, CYS422F, GLN202D, GLN202F, GLN210D, GLN210F, GLN224D, GLN224F, GLN225D, GLN225F, GLN270D, GLN279F, GLN283F, GLN284F, GLN302D, GLN354D, GLN354F, GLN462F, GLN494D, GLN494F, GLN501D, GLU161D, GLU161F, GLU163D, GLU163F, GLU218D, GLU218F, GLU222D, GLU222F, GLU232D, GLU232F, GLU236D, GLU236F, GLU256D, GLU295D, GLU356D, GLU356F, GLU378D, GLU463F, GLU472F, GLU487D, GLU487F, GLU497D, GLU497F, GLU511D, GLU511F, GLY162D, GLY162F, GLY184D, GLY184F, GLY242D, GLY307D, GLY340F, GLY347D, GLY453F, GLY464F, GLY471F, GLY514D, GLY514F, HIS159D, HIS159F, HIS317F, ILE167D, ILE167F, ILE199D, ILE199F, ILE206D, ILE206F, ILE214D, ILE214F, ILE217D, ILE217F, ILE221D, ILE221F, ILE233D, ILE233F, ILE261D, ILE266D, ILE280F, ILE288D, ILE309D, ILE332F, ILE407F, ILE474F, ILE475F, ILE492D, ILE492F, ILE499D, ILE499F, ILE506D, ILE506F, LEU158D, LEU158F, LEU160D, LEU160F, LEU171D, LEU171F, LEU172D, LEU172F, LEU181D, LEU181F, LEU188D, LEU188F, LEU193D, LEU193F, LEU195D, LEU195F, LEU203D, LEU203F, LEU204D, LEU204F, LEU230D, LEU231D, LEU231F, LEU252D, LEU257D, LEU258D, LEU260D, LEU297D, LEU303D, LEU305D, LEU373D, LEU375D, LEU381D, LEU456F, LEU467F, LEU481D, LEU481F, LEU503D, LEU503F, LEU512D, LEU512F, LEU513D, LEU513F, LYS156D, LYS156F, LYS166D, LYS166F, LYS168D, LYS168F, LYS176D, LYS176F, LYS191D, LYS191F, LYS196D, LYS196F, LYS201D, LYS201F, LYS209D, LYS209F, LYS226D, LYS315F, LYS359F, LYS390D, LYS394D, LYS394F, LYS399F, LYS419F, LYS421F, LYS427F, LYS461F, LYS465F, LYS470F, LYS498D, LYS498F, LYS508D, LYS508F, MET251D, MET251F, MET264D, MET289D, MET370D, MET396F, PHE223D, PHE237D, PHE351D, PHE477D, PHE477F, PHE483D, PHE483F, PHE488D, PHE488F, PHE505D, PHE505F, PRO205D, PRO205F, PRO246F, PRO265D, PRO304D, PRO320F, PRO353D, PRO353F, PRO376D, PRO389D, PRO473F, PRO480D, PRO480F, PRO484D, PRO484F, SER155D, SER155F, SER169D, SER169F, SER173D, SER173F, SER180D, SER180F, SER182D, SER182F, SER186D, SER186F, SER190D, SER190F, SER211D, SER211F, SER213D, SER213F, SER215D, SER215F, SER238D, SER248F, SER255D, SER259D, SER319F, SER348D, SER350D, SER372D, SER377D, SER398F, SER403F, SER404F, SER405F, SER415F, SER451F, SER466F, SER485D, SER485F, SER491D, SER491F, SER493D, SER493F, SER502D, SER502F, SER509D, SER509F, THR174D, THR174F, THR189D, THR189F, THR219D, THR219F, THR234D, THR244D, THR244F, THR245F, THR249F, THR253D, THR267D, THR311D, THR318F, THR335F, THR337F, THR369D, THR374D, THR397F, THR400F, THR420F, THR449F, THR455F, TYR198D, TYR198F, TYR250D, TYR250F, TYR286D, TYR299D, TYR306D, TYR391D, TYR417F, TYR457F, TYR458F, TYR468F, TYR478D, TYR478F, VAL152D, VAL154D, VAL157D, VAL157F, VAL164D, VAL164F, VAL178D, VAL178F, VAL179D, VAL179F, VAL185D, VAL185F, VAL187D, VAL187F, VAL192D, VAL192F, VAL207D, VAL207F, VAL220D, VAL220F, VAL239D, VAL239F, VAL243D, VAL247F, VAL278F, VAL281F, VAL296D, VAL300D, VAL301D, VAL308D, VAL349D, VAL379D, VAL402F, VAL406F, VAL452F, VAL469F, VAL482D, VAL482F, VAL495D, VAL495F
• D-H: ARG429H, ASN426H, ASN428H, GLN202D, GLY430H, ILE206D, ILE431H, ILE432H, LYS201D, LYS209D, PRO205D
• E-F: ALA241F, ALA298F, ALA346F, ALA39E, ALA412F, ALA47E, ALA74E, ALA89E, ARG229F, ARG235F, ARG336F, ARG339F, ARG364F, ARG49E, ASN208F, ASN216F, ASN227F, ASN228F, ASN240F, ASN262F, ASN277F, ASN27E, ASN345F, ASN363F, ASN371F, ASN380F, ASN383F, ASN388F, ASN437F, ASN444F, ASN63E, ASN67E, ASN70E, ASN88E, ASP263F, ASP310F, ASP338F, ASP344F, ASP368F, ASP385F, ASP440F, ASP73E, ASP84E, CYS212F, CYS313F, CYS322F, CYS343F, CYS358F, CYS367F, CYS37E, CYS382F, CYS393F, CYS416F, CYS439F, CYS69E, GLN210F, GLN224F, GLN26E, GLN270F, GLN283F, GLN284F, GLN302F, GLN34E, GLN361F, GLN81E, GLN94E, GLN98E, GLU218F, GLU222F, GLU236F, GLU256F, GLU294F, GLU295F, GLU30E, GLU31E, GLU60E, GLU66E, GLU82E, GLU92E, GLY242F, GLY307F, GLY340F, GLY411F, GLY438F, GLY43E, GLY51E, GLY71E, HIS317F, ILE206F, ILE214F, ILE217F, ILE221F, ILE233F, ILE261F, ILE266F, ILE280F, ILE288F, ILE28E, ILE291F, ILE292F, ILE309F, ILE386F, ILE395F, ILE407F, ILE413F, ILE57E, ILE59E, ILE64E, ILE79E, LEU230F, LEU231F, LEU252F, LEU257F, LEU260F, LEU273F, LEU297F, LEU303F, LEU305F, LEU316F, LEU321F, LEU334F, LEU381F, LEU410F, LEU45E, LEU48E, LEU61E, LEU78E, LEU83E, LEU93E, LEU95E, LEU96E, LYS209F, LYS226F, LYS293F, LYS315F, LYS359F, LYS42E, LYS445F, LYS65E, LYS68E, LYS77E, LYS80E, LYS85E, LYS87E, MET251F, MET264F, MET274F, MET289F, MET370F, MET97E, PHE223F, PHE237F, PHE32E, PHE351F, PHE352F, PHE366F, PHE387F, PRO205F, PRO265F, PRO304F, PRO312F, PRO320F, SER211F, SER213F, SER215F, SER238F, SER259F, SER285F, SER287F, SER290F, SER319F, SER350F, SER35E, SER362F, SER372F, SER38E, SER404F, SER409F, SER415F, SER41E, SER443F, SER46E, SER55E, SER62E, THR219F, THR234F, THR245F, THR253F, THR29E, THR311F, THR318F, THR335F, THR357F, THR369F, THR36E, THR408F, THR50E, THR54E, THR58E, THR72E, THR91E, TRP314F, TRP341F, TRP52E, TYR250F, TYR286F, TYR299F, TYR306F, TYR33E, TYR342F, TYR417F, TYR441F, TYR44E, TYR53E, TYR86E, VAL207F, VAL220F, VAL239F, VAL243F, VAL247F, VAL281F, VAL296F, VAL300F, VAL301F, VAL308F, VAL349F, VAL360F, VAL365F, VAL384F, VAL406F, VAL40E, VAL414F, VAL442F, VAL56E, VAL76E, VAL90E
• E-H: GLU60E, LYS470H, THR58E, TYR468H
• F-M: LYS75M, PRO265F
• G-H: ALA241H, ALA298H, ALA346H, ALA39G, ALA412H, ALA47G, ALA74G, ALA89G, ARG229H, ARG235H, ARG336H, ARG339H, ARG364H, ARG49G, ASN208H, ASN216H, ASN227H, ASN228H, ASN240H, ASN262H, ASN277H, ASN27G, ASN345H, ASN363H, ASN371H, ASN380H, ASN383H, ASN388H, ASN444H, ASN63G, ASN67G, ASN70G, ASN88G, ASP263H, ASP310H, ASP338H, ASP344H, ASP368H, ASP385H, ASP440H, ASP73G, ASP84G, CYS212H, CYS313H, CYS322H, CYS343H, CYS358H, CYS367H, CYS37G, CYS382H, CYS393H, CYS439H, CYS69G, GLN210H, GLN224H, GLN225H, GLN26G, GLN270H, GLN283H, GLN284H, GLN302H, GLN34G, GLN361H, GLN81G, GLN94G, GLU218H, GLU222H, GLU232H, GLU236H, GLU256H, GLU294H, GLU295H, GLU30G, GLU31G, GLU60G, GLU66G, GLU82G, GLU92G, GLY242H, GLY307H, GLY340H, GLY411H, GLY438H, GLY43G, GLY51G, GLY71G, HIS317H, ILE206H, ILE214H, ILE217H, ILE221H, ILE233H, ILE261H, ILE266H, ILE280H, ILE288H, ILE28G, ILE291H, ILE292H, ILE309H, ILE386H, ILE395H, ILE407H, ILE413H, ILE57G, ILE59G, ILE64G, ILE79G, LEU230H, LEU231H, LEU252H, LEU257H, LEU260H, LEU273H, LEU297H, LEU303H, LEU305H, LEU316H, LEU321H, LEU334H, LEU381H, LEU410H, LEU45G, LEU48G, LEU61G, LEU78G, LEU83G, LEU93G, LEU95G, LEU96G, LYS209H, LYS226H, LYS293H, LYS315H, LYS359H, LYS42G, LYS445H, LYS65G, LYS68G, LYS77G, LYS80G, LYS85G, LYS87G, MET251H, MET264H, MET274H, MET289H, MET370H, MET97G, PHE223H, PHE237H, PHE32G, PHE352H, PHE366H, PHE387H, PRO205H, PRO265H, PRO304H, PRO312H, PRO320H, SER211H, SER213H, SER215H, SER238H, SER259H, SER285H, SER287H, SER290H, SER319H, SER350H, SER35G, SER362H, SER372H, SER38G, SER404H, SER409H, SER415H, SER41G, SER443H, SER46G, SER55G, SER62G, THR219H, THR234H, THR245H, THR253H, THR29G, THR311H, THR318H, THR335H, THR357H, THR369H, THR36G, THR408H, THR50G, THR54G, THR58G, THR72G, THR91G, TRP314H, TRP341H, TRP52G, TYR250H, TYR286H, TYR299H, TYR306H, TYR33G, TYR342H, TYR417H, TYR441H, TYR44G, TYR53G, TYR86G, VAL207H, VAL220H, VAL239H, VAL243H, VAL247H, VAL281H, VAL296H, VAL300H, VAL301H, VAL308H, VAL349H, VAL360H, VAL365H, VAL384H, VAL406H, VAL40G, VAL414H, VAL442H, VAL56G, VAL76G, VAL90G
• G-L: ALA74G, ASN476L, ASP479L, ASP73G, GLN81G, ILE474L, ILE475L, LYS75G, PHE477L, THR72G, TYR478L, VAL76G
• G-N: ALA74G, ALA89G, ARG229N, ARG282N, ARG49G, ASN216N, ASN227N, ASN228N, ASN254N, ASN276N, ASN277N, ASN460N, ASN476N, ASN63G, ASN67G, ASN70G, ASN88G, ASP73G, ASP84G, CYS212N, CYS69G, GLN210N, GLN224N, GLN225N, GLN279N, GLN283N, GLN361N, GLN462N, GLN81G, GLN94G, GLU218N, GLU222N, GLU232N, GLU256N, GLU463N, GLU472N, GLU60G, GLU66G, GLU82G, GLU92G, GLY464N, GLY471N, GLY51G, GLY71G, ILE214N, ILE217N, ILE221N, ILE280N, ILE407N, ILE474N, ILE475N, ILE57G, ILE59G, ILE64G, ILE79G, LEU231N, LEU252N, LEU257N, LEU258N, LEU456N, LEU467N, LEU48G, LEU61G, LEU78G, LEU83G, LEU93G, LEU95G, LEU96G, LYS226N, LYS461N, LYS465N, LYS470N, LYS65G, LYS68G, LYS75G, LYS77G, LYS80G, LYS85G, MET97G, PHE223N, PHE477N, PRO473N, PRO480N, SER211N, SER213N, SER215N, SER248N, SER255N, SER275N, SER405N, SER466N, SER46G, SER55G, SER62G, THR219N, THR249N, THR253N, THR449N, THR455N, THR50G, THR54G, THR58G, THR72G, THR91G, TRP52G, TYR250N, TYR457N, TYR458N, TYR468N, TYR478N, TYR53G, TYR86G, VAL220N, VAL247N, VAL278N, VAL281N, VAL450N, VAL452N, VAL459N, VAL469N, VAL56G, VAL76G
• H-I: ALA74I, ALA89I, ARG229H, ARG235H, ARG282H, ARG49I, ASN216H, ASN227H, ASN228H, ASN254H, ASN276H, ASN277H, ASN460H, ASN476H, ASN63I, ASN67I, ASN70I, ASN88I, ASP73I, ASP84I, CYS212H, CYS69I, GLN210H, GLN224H, GLN225H, GLN279H, GLN283H, GLN361H, GLN462H, GLN81I, GLN94I, GLU218H, GLU222H, GLU232H, GLU256H, GLU463H, GLU472H, GLU60I, GLU66I, GLU82I, GLU92I, GLY464H, GLY471H, GLY51I, GLY71I, ILE214H, ILE217H, ILE221H, ILE280H, ILE407H, ILE474H, ILE475H, ILE57I, ILE59I, ILE64I, ILE79I, LEU231H, LEU252H, LEU257H, LEU258H, LEU456H, LEU467H, LEU48I, LEU61I, LEU78I, LEU83I, LEU93I, LEU95I, LEU96I, LYS226H, LYS461H, LYS465H, LYS470H, LYS65I, LYS68I, LYS75I, LYS77I, LYS80I, LYS85I, MET97I, PHE223H, PHE477H, PRO473H, PRO480H, SER211H, SER213H, SER215H, SER248H, SER255H, SER275H, SER405H, SER466H, SER46I, SER55I, SER62I, THR219H, THR249H, THR253H, THR455H, THR50I, THR54I, THR58I, THR72I, THR91I, TRP52I, TYR250H, TYR457H, TYR458H, TYR468H, TYR478H, TYR53I, TYR86I, VAL207H, VAL220H, VAL247H, VAL278H, VAL281H, VAL450H, VAL459H, VAL469H, VAL56I, VAL76I
• H-L: ALA147H, ALA149H, ALA153H, ALA170H, ALA170L, ALA177H, ALA177L, ALA241L, ALA298L, ALA346L, ALA355H, ALA490H, ALA490L, ALA504H, ALA504L, ARG229L, ARG235H, ARG235L, ARG282H, ARG336H, ARG339H, ARG507H, ARG507L, ASN165H, ASN165L, ASN175H, ASN175L, ASN183H, ASN183L, ASN197H, ASN197L, ASN208H, ASN208L, ASN216H, ASN216L, ASN227L, ASN228H, ASN240H, ASN240L, ASN262L, ASN345L, ASN371L, ASN388L, ASN454H, ASN460H, ASN476H, ASN496H, ASN496L, ASN500H, ASN500L, ASP194H, ASP194L, ASP200H, ASP200L, ASP263L, ASP344L, ASP392L, ASP401H, ASP479H, ASP479L, ASP486H, ASP486L, ASP489H, ASP489L, ASP510H, ASP510L, CYS212H, CYS212L, CYS333H, CYS393L, GLN202H, GLN202L, GLN210H, GLN210L, GLN224H, GLN224L, GLN225H, GLN225L, GLN270L, GLN279H, GLN283H, GLN284H, GLN302L, GLN354H, GLN354L, GLN462H, GLN494H, GLN494L, GLN501L, GLU161H, GLU161L, GLU163H, GLU163L, GLU218H, GLU218L, GLU222H, GLU222L, GLU232H, GLU232L, GLU236H, GLU236L, GLU256L, GLU295L, GLU356H, GLU356L, GLU378L, GLU463H, GLU472H, GLU487H, GLU487L, GLU497H, GLU497L, GLU511H, GLU511L, GLY162H, GLY162L, GLY184H, GLY184L, GLY242L, GLY307L, GLY340H, GLY347L, GLY453H, GLY464H, GLY471H, GLY514H, GLY514L, HIS159H, HIS159L, HIS317H, ILE148H, ILE167H, ILE167L, ILE199H, ILE199L, ILE206H, ILE206L, ILE214H, ILE214L, ILE217H, ILE217L, ILE221H, ILE221L, ILE233H, ILE233L, ILE261L, ILE266L, ILE280H, ILE288L, ILE309L, ILE407H, ILE474H, ILE475H, ILE492H, ILE492L, ILE499H, ILE499L, ILE506H, ILE506L, LEU158H, LEU160H, LEU160L, LEU171H, LEU171L, LEU172H, LEU172L, LEU181H, LEU181L, LEU188H, LEU188L, LEU193H, LEU193L, LEU195H, LEU195L, LEU203H, LEU203L, LEU204H, LEU204L, LEU230L, LEU231H, LEU231L, LEU252H, LEU252L, LEU257L, LEU258L, LEU260L, LEU297L, LEU303L, LEU305L, LEU373L, LEU375L, LEU456H, LEU467H, LEU481H, LEU481L, LEU503H, LEU503L, LEU512H, LEU512L, LEU513H, LEU513L, LYS156H, LYS156L, LYS166H, LYS166L, LYS168H, LYS168L, LYS176H, LYS176L, LYS191H, LYS191L, LYS196H, LYS196L, LYS201H, LYS201L, LYS209H, LYS209L, LYS226L, LYS315H, LYS359H, LYS390L, LYS394H, LYS394L, LYS399H, LYS421H, LYS461H, LYS465H, LYS470H, LYS498H, LYS498L, LYS508H, LYS508L, MET251H, MET251L, MET264L, MET289L, MET370L, MET396H, PHE223L, PHE237L, PHE351L, PHE387L, PHE477H, PHE477L, PHE483H, PHE483L, PHE488H, PHE488L, PHE505H, PHE505L, PRO205H, PRO205L, PRO246H, PRO265L, PRO320H, PRO353H, PRO376L, PRO389L, PRO473H, PRO480H, PRO480L, PRO484H, PRO484L, SER155L, SER169H, SER169L, SER173H, SER173L, SER180H, SER180L, SER182H, SER182L, SER186H, SER186L, SER190H, SER190L, SER211H, SER211L, SER213H, SER213L, SER215H, SER215L, SER238L, SER248H, SER255L, SER259L, SER319H, SER348L, SER350L, SER372L, SER377L, SER398H, SER403H, SER404H, SER405H, SER415H, SER451H, SER466H, SER485H, SER485L, SER491H, SER491L, SER493H, SER493L, SER502H, SER502L, SER509H, SER509L, THR174H, THR174L, THR189H, THR189L, THR219H, THR219L, THR234L, THR244H, THR244L, THR245H, THR249H, THR253L, THR267L, THR311L, THR318H, THR335H, THR337H, THR357L, THR369L, THR374L, THR397H, THR400H, THR408H, THR420H, THR455H, TYR198H, TYR198L, TYR250H, TYR250L, TYR286L, TYR299L, TYR306L, TYR391L, TYR417H, TYR457H, TYR458H, TYR468H, TYR478H, TYR478L, VAL152H, VAL154H, VAL154L, VAL157H, VAL157L, VAL164H, VAL164L, VAL178H, VAL178L, VAL179H, VAL179L, VAL185H, VAL185L, VAL187H, VAL187L, VAL192H, VAL192L, VAL207H, VAL207L, VAL220L, VAL239H, VAL239L, VAL243L, VAL247H, VAL278H, VAL281H, VAL296L, VAL300L, VAL301L, VAL308L, VAL349L, VAL379L, VAL402H, VAL406H, VAL452H, VAL469H, VAL482H, VAL482L, VAL495H, VAL495L
• H-M: ALA74M, ASN476H, ASP479H, ASP73M, GLN81M, GLY71M, ILE214H, ILE217H, ILE221H, ILE474H, ILE475H, LEU78M, LYS75M, PHE477H, THR72M, TYR478H, VAL76M
• H-N: ALA149H, ALA153H, ALA153N, ALA170H, ALA170N, ALA177H, ALA177N, ALA241H, ALA298H, ALA346H, ALA355N, ALA490H, ALA490N, ALA504H, ALA504N, ARG229H, ARG235H, ARG235N, ARG282N, ARG336N, ARG339N, ARG507H, ARG507N, ASN165H, ASN165N, ASN175H, ASN175N, ASN183H, ASN183N, ASN197H, ASN197N, ASN208H, ASN208N, ASN216H, ASN216N, ASN227H, ASN228N, ASN240H, ASN240N, ASN262H, ASN345H, ASN371H, ASN388H, ASN454N, ASN460N, ASN476N, ASN496H, ASN496N, ASN500H, ASN500N, ASP194H, ASP194N, ASP200H, ASP200N, ASP263H, ASP338N, ASP344H, ASP392H, ASP401N, ASP479H, ASP479N, ASP486H, ASP486N, ASP489H, ASP489N, ASP510H, ASP510N, CYS212H, CYS212N, CYS333N, CYS393H, GLN202H, GLN202N, GLN210H, GLN210N, GLN224H, GLN224N, GLN225H, GLN225N, GLN270H, GLN279N, GLN283N, GLN284N, GLN302H, GLN354H, GLN354N, GLN462N, GLN494H, GLN494N, GLN501H, GLU161H, GLU161N, GLU163H, GLU163N, GLU218H, GLU218N, GLU222H, GLU232H, GLU232N, GLU236H, GLU236N, GLU256H, GLU295H, GLU356H, GLU356N, GLU378H, GLU463N, GLU472N, GLU487H, GLU487N, GLU497H, GLU497N, GLU511H, GLU511N, GLY151H, GLY162H, GLY162N, GLY184H, GLY184N, GLY242H, GLY307H, GLY340N, GLY347H, GLY453N, GLY464N, GLY471N, GLY514H, GLY514N, HIS159H, HIS159N, HIS317N, ILE167H, ILE167N, ILE199H, ILE199N, ILE206H, ILE206N, ILE214H, ILE214N, ILE217H, ILE217N, ILE221H, ILE221N, ILE233H, ILE233N, ILE261H, ILE266H, ILE280N, ILE288H, ILE309H, ILE407N, ILE474N, ILE475N, ILE492H, ILE492N, ILE499H, ILE499N, ILE506H, ILE506N, LEU158H, LEU158N, LEU160H, LEU160N, LEU171H, LEU171N, LEU172H, LEU172N, LEU181H, LEU181N, LEU188H, LEU188N, LEU193H, LEU193N, LEU195H, LEU195N, LEU203H, LEU203N, LEU204H, LEU204N, LEU230H, LEU231H, LEU231N, LEU252H, LEU252N, LEU257H, LEU258H, LEU260H, LEU297H, LEU303H, LEU305H, LEU316N, LEU373H, LEU375H, LEU381H, LEU456N, LEU467N, LEU481H, LEU481N, LEU503H, LEU503N, LEU512H, LEU512N, LEU513H, LEU513N, LYS156H, LYS156N, LYS166H, LYS166N, LYS168H, LYS168N, LYS176H, LYS176N, LYS191H, LYS191N, LYS196H, LYS196N, LYS201H, LYS201N, LYS209H, LYS209N, LYS226H, LYS315N, LYS359N, LYS390H, LYS394H, LYS394N, LYS399N, LYS421N, LYS427N, LYS461N, LYS465N, LYS470N, LYS498H, LYS498N, LYS508H, LYS508N, MET251H, MET251N, MET264H, MET289H, MET370H, MET396N, PHE223H, PHE237H, PHE351H, PHE352H, PHE387H, PHE477H, PHE477N, PHE483H, PHE483N, PHE488H, PHE488N, PHE505H, PHE505N, PRO205H, PRO205N, PRO246N, PRO265H, PRO320N, PRO353H, PRO353N, PRO376H, PRO389H, PRO473N, PRO480H, PRO480N, PRO484H, PRO484N, SER155H, SER155N, SER169H, SER169N, SER173H, SER173N, SER180H, SER180N, SER182H, SER182N, SER186H, SER186N, SER190H, SER190N, SER211H, SER211N, SER213H, SER213N, SER215H, SER215N, SER238H, SER248N, SER255H, SER259H, SER319N, SER348H, SER350H, SER372H, SER377H, SER398N, SER403N, SER404N, SER405N, SER415N, SER451N, SER466N, SER485H, SER485N, SER491H, SER491N, SER493H, SER493N, SER502H, SER502N, SER509H, SER509N, THR174H, THR174N, THR189H, THR189N, THR219H, THR219N, THR234H, THR244H, THR244N, THR245N, THR249N, THR253H, THR267H, THR311H, THR318N, THR335N, THR337N, THR369H, THR374H, THR397N, THR400N, THR408N, THR420N, THR449N, THR455N, TYR198H, TYR198N, TYR250H, TYR250N, TYR286H, TYR299H, TYR306H, TYR391H, TYR417N, TYR457N, TYR458N, TYR468N, TYR478H, TYR478N, VAL152H, VAL152N, VAL154H, VAL154N, VAL157H, VAL157N, VAL164H, VAL164N, VAL178H, VAL178N, VAL179H, VAL179N, VAL185H, VAL185N, VAL187H, VAL187N, VAL192H, VAL192N, VAL207H, VAL207N, VAL220H, VAL220N, VAL239H, VAL239N, VAL243H, VAL247N, VAL278N, VAL281N, VAL296H, VAL300H, VAL301H, VAL308H, VAL349H, VAL379H, VAL402N, VAL406N, VAL452N, VAL469N, VAL482H, VAL482N, VAL495H, VAL495N
• I-L: ALA241L, ALA298L, ALA346L, ALA39I, ALA412L, ALA47I, ALA74I, ALA89I, ARG229L, ARG235L, ARG282L, ARG336L, ARG339L, ARG364L, ARG49I, ASN208L, ASN216L, ASN227L, ASN228L, ASN240L, ASN262L, ASN277L, ASN27I, ASN345L, ASN363L, ASN371L, ASN380L, ASN383L, ASN388L, ASN444L, ASN63I, ASN67I, ASN70I, ASN88I, ASP263L, ASP310L, ASP338L, ASP344L, ASP368L, ASP385L, ASP440L, ASP73I, CYS212L, CYS313L, CYS322L, CYS343L, CYS358L, CYS367L, CYS37I, CYS382L, CYS393L, CYS416L, CYS439L, CYS69I, GLN210L, GLN224L, GLN225L, GLN270L, GLN283L, GLN284L, GLN302L, GLN34I, GLN361L, GLN81I, GLN94I, GLU218L, GLU222L, GLU236L, GLU256L, GLU294L, GLU295L, GLU30I, GLU31I, GLU60I, GLU66I, GLU82I, GLU92I, GLY242L, GLY307L, GLY340L, GLY411L, GLY438L, GLY43I, GLY51I, GLY71I, HIS317L, ILE206L, ILE214L, ILE217L, ILE221L, ILE233L, ILE261L, ILE266L, ILE280L, ILE288L, ILE28I, ILE291L, ILE292L, ILE309L, ILE386L, ILE395L, ILE407L, ILE413L, ILE57I, ILE59I, ILE64I, ILE79I, LEU230L, LEU231L, LEU252L, LEU257L, LEU260L, LEU273L, LEU297L, LEU303L, LEU305L, LEU316L, LEU321L, LEU334L, LEU381L, LEU410L, LEU45I, LEU48I, LEU61I, LEU78I, LEU83I, LEU93I, LEU95I, LEU96I, LYS209L, LYS226L, LYS293L, LYS315L, LYS359L, LYS42I, LYS65I, LYS68I, LYS77I, LYS80I, LYS85I, LYS87I, MET251L, MET264L, MET274L, MET289L, MET370L, MET97I, PHE223L, PHE237L, PHE32I, PHE351L, PHE352L, PHE366L, PHE387L, PRO205L, PRO265L, PRO304L, PRO312L, PRO320L, SER211L, SER213L, SER215L, SER238L, SER259L, SER285L, SER287L, SER290L, SER319L, SER348L, SER350L, SER35I, SER362L, SER372L, SER38I, SER409L, SER415L, SER41I, SER443L, SER46I, SER55I, SER62I, THR219L, THR234L, THR245L, THR253L, THR29I, THR311L, THR318L, THR335L, THR357L, THR369L, THR36I, THR408L, THR50I, THR54I, THR58I, THR72I, THR91I, TRP314L, TRP341L, TRP52I, TYR250L, TYR286L, TYR299L, TYR306L, TYR33I, TYR342L, TYR417L, TYR441L, TYR44I, TYR53I, TYR86I, VAL207L, VAL220L, VAL239L, VAL243L, VAL247L, VAL281L, VAL296L, VAL300L, VAL301L, VAL308L, VAL349L, VAL360L, VAL365L, VAL384L, VAL406L, VAL40I, VAL414L, VAL442L, VAL56I, VAL76I, VAL90I
• I-N: ALA74I, ASN476N, ASP479N, ASP73I, GLN81I, ILE217N, ILE221N, ILE474N, ILE475N, LEU78I, LYS75I, PHE477N, THR72I, TYR478N, VAL76I
• L-M: ALA74M, ALA89M, ARG229L, ARG235L, ARG282L, ARG49M, ASN216L, ASN227L, ASN228L, ASN254L, ASN276L, ASN277L, ASN460L, ASN476L, ASN63M, ASN67M, ASN70M, ASN88M, ASP479L, ASP73M, ASP84M, CYS212L, CYS69M, GLN210L, GLN224L, GLN225L, GLN279L, GLN283L, GLN361L, GLN462L, GLN81M, GLN94M, GLN98M, GLU218L, GLU222L, GLU232L, GLU256L, GLU463L, GLU472L, GLU60M, GLU66M, GLU82M, GLU92M, GLY464L, GLY471L, GLY51M, GLY71M, ILE214L, ILE217L, ILE221L, ILE280L, ILE407L, ILE474L, ILE475L, ILE57M, ILE59M, ILE64M, ILE79M, LEU231L, LEU252L, LEU257L, LEU258L, LEU273L, LEU456L, LEU467L, LEU48M, LEU61M, LEU78M, LEU83M, LEU93M, LEU95M, LEU96M, LYS226L, LYS272L, LYS461L, LYS465L, LYS470L, LYS65M, LYS68M, LYS75M, LYS77M, LYS80M, LYS85M, MET274L, MET97M, PHE223L, PHE477L, PRO246L, PRO473L, PRO480L, SER211L, SER213L, SER215L, SER248L, SER255L, SER275L, SER362L, SER405L, SER451L, SER466L, SER46M, SER55M, SER62M, THR219L, THR249L, THR253L, THR455L, THR50M, THR54M, THR58M, THR72M, THR91M, TRP52M, TYR250L, TYR457L, TYR458L, TYR468L, TYR478L, TYR53M, TYR86M, VAL220L, VAL247L, VAL278L, VAL281L, VAL406L, VAL450L, VAL452L, VAL459L, VAL469L, VAL56M, VAL76M
• L-N: ALA153N, ALA170L, ALA170N, ALA177L, ALA177N, ALA241N, ALA298N, ALA346N, ALA355L, ALA490L, ALA490N, ALA504L, ALA504N, ARG229N, ARG235L, ARG235N, ARG282L, ARG336L, ARG339L, ARG507L, ARG507N, ASN165L, ASN165N, ASN175L, ASN175N, ASN183L, ASN183N, ASN197L, ASN197N, ASN208L, ASN208N, ASN216L, ASN216N, ASN227N, ASN228L, ASN228N, ASN240L, ASN240N, ASN262N, ASN345N, ASN371N, ASN388N, ASN454L, ASN460L, ASN476L, ASN496L, ASN496N, ASN500L, ASN500N, ASP194L, ASP194N, ASP200L, ASP200N, ASP263N, ASP344N, ASP392N, ASP401L, ASP479L, ASP479N, ASP486L, ASP489L, ASP489N, ASP510L, ASP510N, CYS212L, CYS212N, CYS322L, CYS333L, CYS393N, CYS422L, GLN202L, GLN202N, GLN210L, GLN210N, GLN224L, GLN224N, GLN225L, GLN225N, GLN270N, GLN279L, GLN283L, GLN302N, GLN354L, GLN354N, GLN462L, GLN494L, GLN494N, GLN501N, GLU161L, GLU161N, GLU163L, GLU163N, GLU218L, GLU218N, GLU222L, GLU222N, GLU232L, GLU232N, GLU236L, GLU236N, GLU256N, GLU295N, GLU356L, GLU356N, GLU378N, GLU463L, GLU472L, GLU487L, GLU487N, GLU497L, GLU497N, GLU511L, GLU511N, GLY162L, GLY162N, GLY184L, GLY184N, GLY242N, GLY307N, GLY340L, GLY347N, GLY453L, GLY464L, GLY471L, GLY514L, GLY514N, HIS159L, HIS159N, HIS317L, ILE167L, ILE167N, ILE199L, ILE199N, ILE206L, ILE206N, ILE214L, ILE214N, ILE217L, ILE217N, ILE221L, ILE221N, ILE233L, ILE233N, ILE261N, ILE266N, ILE280L, ILE288N, ILE309N, ILE332L, ILE407L, ILE474L, ILE475L, ILE492L, ILE492N, ILE499L, ILE499N, ILE506L, ILE506N, LEU158L, LEU158N, LEU160L, LEU160N, LEU171L, LEU171N, LEU172L, LEU172N, LEU181L, LEU181N, LEU188L, LEU188N, LEU193L, LEU193N, LEU195L, LEU195N, LEU203L, LEU203N, LEU204L, LEU204N, LEU230N, LEU231L, LEU231N, LEU252N, LEU257N, LEU258N, LEU260N, LEU297N, LEU303N, LEU305N, LEU316L, LEU373N, LEU375N, LEU381N, LEU456L, LEU467L, LEU481L, LEU481N, LEU503L, LEU503N, LEU512L, LEU512N, LEU513L, LEU513N, LYS156L, LYS156N, LYS166L, LYS166N, LYS168L, LYS168N, LYS176L, LYS176N, LYS191L, LYS191N, LYS196L, LYS196N, LYS201L, LYS201N, LYS209L, LYS209N, LYS226N, LYS315L, LYS359L, LYS390N, LYS394L, LYS394N, LYS399L, LYS421L, LYS427L, LYS461L, LYS465L, LYS470L, LYS498L, LYS498N, LYS508L, LYS508N, MET251L, MET251N, MET264N, MET289N, MET370N, MET396L, PHE223N, PHE237N, PHE351N, PHE387N, PHE477L, PHE477N, PHE483L, PHE483N, PHE488L, PHE488N, PHE505L, PHE505N, PRO205L, PRO205N, PRO246L, PRO265N, PRO320L, PRO353L, PRO376N, PRO389N, PRO473L, PRO480L, PRO480N, PRO484L, PRO484N, SER155N, SER169L, SER169N, SER173L, SER173N, SER180L, SER180N, SER182L, SER182N, SER186L, SER186N, SER190L, SER190N, SER211L, SER211N, SER213L, SER213N, SER215L, SER215N, SER238N, SER248L, SER255N, SER259N, SER319L, SER348N, SER350N, SER372N, SER377N, SER398L, SER403L, SER404L, SER405L, SER415L, SER451L, SER466L, SER485L, SER491L, SER491N, SER493L, SER493N, SER502L, SER502N, SER509L, SER509N, THR174L, THR174N, THR189L, THR189N, THR219L, THR219N, THR234N, THR244L, THR244N, THR245L, THR249L, THR253N, THR267N, THR311N, THR318L, THR335L, THR337L, THR369N, THR374N, THR397L, THR400L, THR420L, THR449L, THR455L, TYR198L, TYR198N, TYR250L, TYR250N, TYR286N, TYR299N, TYR306N, TYR391N, TYR417L, TYR457L, TYR458L, TYR468L, TYR478L, TYR478N, VAL152N, VAL154L, VAL154N, VAL157L, VAL157N, VAL164L, VAL164N, VAL178L, VAL178N, VAL179L, VAL179N, VAL185L, VAL185N, VAL187L, VAL187N, VAL192L, VAL192N, VAL207L, VAL207N, VAL220L, VAL220N, VAL239L, VAL239N, VAL243N, VAL247L, VAL278L, VAL281L, VAL296N, VAL300N, VAL301N, VAL308N, VAL349N, VAL379N, VAL402L, VAL406L, VAL452L, VAL469L, VAL482L, VAL482N, VAL495L, VAL495N
• M-N: ALA241N, ALA298N, ALA346N, ALA39M, ALA412N, ALA47M, ALA74M, ALA89M, ARG229N, ARG235N, ARG336N, ARG339N, ARG364N, ARG49M, ASN208N, ASN216N, ASN227N, ASN228N, ASN240N, ASN262N, ASN277N, ASN27M, ASN345N, ASN363N, ASN371N, ASN380N, ASN383N, ASN388N, ASN444N, ASN63M, ASN67M, ASN70M, ASN88M, ASP263N, ASP310N, ASP344N, ASP368N, ASP385N, ASP440N, ASP73M, ASP84M, CYS212N, CYS313N, CYS322N, CYS343N, CYS358N, CYS367N, CYS37M, CYS382N, CYS393N, CYS439N, CYS69M, GLN210N, GLN224N, GLN270N, GLN283N, GLN284N, GLN302N, GLN34M, GLN361N, GLN81M, GLN94M, GLU218N, GLU222N, GLU232N, GLU236N, GLU256N, GLU294N, GLU295N, GLU30M, GLU31M, GLU60M, GLU66M, GLU82M, GLU92M, GLY242N, GLY307N, GLY340N, GLY411N, GLY438N, GLY43M, GLY51M, GLY71M, HIS317N, ILE206N, ILE214N, ILE217N, ILE221N, ILE233N, ILE261N, ILE266N, ILE280N, ILE288N, ILE28M, ILE291N, ILE292N, ILE309N, ILE386N, ILE395N, ILE407N, ILE413N, ILE57M, ILE59M, ILE64M, ILE79M, LEU230N, LEU231N, LEU252N, LEU257N, LEU260N, LEU273N, LEU297N, LEU303N, LEU305N, LEU316N, LEU321N, LEU334N, LEU381N, LEU410N, LEU45M, LEU48M, LEU61M, LEU78M, LEU83M, LEU93M, LEU95M, LEU96M, LYS209N, LYS226N, LYS293N, LYS315N, LYS359N, LYS42M, LYS65M, LYS68M, LYS77M, LYS80M, LYS85M, LYS87M, MET251N, MET264N, MET274N, MET289N, MET370N, MET97M, PHE223N, PHE237N, PHE32M, PHE351N, PHE352N, PHE366N, PHE387N, PRO205N, PRO265N, PRO304N, PRO312N, PRO320N, SER211N, SER213N, SER215N, SER238N, SER259N, SER285N, SER287N, SER290N, SER319N, SER350N, SER35M, SER362N, SER372N, SER38M, SER409N, SER415N, SER41M, SER443N, SER46M, SER55M, SER62M, THR219N, THR234N, THR245N, THR253N, THR29M, THR311N, THR318N, THR335N, THR357N, THR369N, THR36M, THR408N, THR50M, THR54M, THR58M, THR72M, THR91M, TRP314N, TRP341N, TRP52M, TYR250N, TYR286N, TYR299N, TYR306N, TYR33M, TYR342N, TYR417N, TYR441N, TYR44M, TYR53M, TYR86M, VAL220N, VAL239N, VAL243N, VAL247N, VAL281N, VAL296N, VAL300N, VAL301N, VAL308N, VAL349N, VAL360N, VAL365N, VAL384N, VAL406N, VAL40M, VAL414N, VAL442N, VAL56M, VAL76M, VAL90M