3RQG

cerebral cavernous malformation 3 (ccm3) in complex with paxillin ld4

• Total interactions analyzed: 10
• Total true interactions: 7
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 147
  • Norm. En. per Res.: -3.003
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-51.9958	-19.7219	-369.73	-441.4477	147	20	26	19621	4	34	40
A-C	-8.822	25.6103	-165.915	-149.1267	64	4	7	6242	0	18	21
A-D	0.0	0.0	-16.9255	-16.9255	17	0	0	824	0	3	2
B-C	0.0	0.0	-25.4723	-25.4723	28	0	0	1507	0	6	5
B-D	-8.8357	37.5653	-84.5104	-55.7808	55	6	0	3418	2	23	26
C-D	-39.0012	-37.1992	-380.576	-456.7765	153	16	23	19451	5	30	38
C-E	0.0	-17.6207	-103.717	-121.3377	50	3	8	5247	2	13	11

Interface residues

• A-B: ALA187A, ALA24A, ALA24B, ALA40A, ALA40B, ALA41A, ALA41B, ALA46A, ALA46B, ALA47A, ALA47B, ALA51A, ALA51B, ALA84A, ARG196A, ARG196B, ARG35B, ARG45A, ARG45B, ARG82A, ASN189A, ASN189B, ASN195A, ASN195B, ASN31A, ASN31B, ASN37A, ASN37B, ASN55A, ASN55B, ASN75A, ASN75B, ASP184B, ASP61A, ASP61B, GLN60A, GLN60B, GLU32A, GLU32B, GLU34A, GLU34B, GLU52A, GLU52B, GLU54A, GLU54B, GLU68A, GLU68B, GLU73A, GLU73B, GLU78A, GLY185A, GLY57A, GLY57B, ILE188A, ILE188B, ILE49A, ILE49B, ILE62A, ILE62B, ILE63A, ILE63B, ILE66A, ILE66B, LEU22A, LEU22B, LEU33A, LEU33B, LEU38A, LEU44A, LEU44B, LEU58A, LEU58B, LEU67A, LEU67B, LEU80A, LEU80B, LEU81A, LYS186A, LYS186B, LYS50A, LYS50B, LYS65A, LYS65B, LYS69A, LYS69B, LYS70A, LYS70B, MET17A, MET17B, MET20A, MET20B, MET26A, MET26B, MET64A, MET64B, MET83A, MET83B, PHE191A, PHE191B, PHE30A, PHE30B, PHE48A, PHE48B, PHE76A, PHE76B, PRO21A, PRO21B, PRO28A, PRO28B, PRO56A, PRO56B, SER16A, SER16B, SER193A, SER193B, SER19A, SER19B, SER39A, SER39B, SER71A, SER71B, SER79A, SER79B, THR43A, THR43B, THR59A, THR59B, THR77A, THR77B, TYR23A, TYR23B, TYR27A, TYR27B, VAL18A, VAL18B, VAL192A, VAL192B, VAL25A, VAL25B, VAL29A, VAL29B, VAL36A, VAL36B, VAL72A, VAL72B, VAL74A, VAL74B
• A-C: ALA12C, ALA24A, ALA24C, ALA41A, ALA46A, ARG2C, ARG35A, ARG35C, ARG45A, ARG45C, ASN10C, ASN31A, ASN31C, ASN37A, GLN42A, GLU11C, GLU13C, GLU32A, GLU32C, GLU34A, GLU34C, GLU7C, GLY-1C, HIS0C, ILE49A, ILE49C, LEU22A, LEU22C, LEU33A, LEU38A, LYS9C, MET17A, MET17C, MET1C, MET20A, MET20C, MET26A, MET26C, MET3C, MET5C, MET8C, PHE30A, PHE30C, PRO21A, PRO21C, PRO28A, PRO28C, SER19A, SER19C, SER39A, THR14C, THR15C, THR43A, THR4C, TYR170A, TYR23A, TYR23C, TYR27A, TYR27C, VAL25A, VAL25C, VAL29A, VAL29C, VAL36A
• A-D: ASN75D, GLU73D, GLU94D, LYS183A, LYS69D, LYS70D, MET17A, MET20A, PHE76D, SER16A, SER19A, SER71D, SER79D, TYR23A, VAL18A, VAL72D, VAL74D
• B-C: ALA12C, ALA24C, ARG82B, ASN75B, GLU11C, GLU13C, GLU68B, GLU73B, GLU78B, LEU80B, LYS65B, LYS69B, LYS70B, LYS9C, MET17C, MET20C, MET83B, MET8C, PHE76B, SER16C, SER19C, SER71B, SER79B, THR14C, THR15C, TYR23C, VAL18C, VAL72B
• B-D: ALA84B, ALA84D, ALA85B, ALA85D, ARG108D, ARG126B, ARG126D, ARG82B, ARG82D, ASN122B, ASN122D, ASN75B, ASN75D, ASP119B, ASP119D, ASP123B, ASP86B, ASP86D, ASP87B, ASP87D, GLN112B, GLN112D, GLU78B, GLU78D, GLU89D, ILE121B, ILE121D, LEU80B, LEU80D, LEU81B, LEU81D, LYS116B, LYS116D, MET83B, MET83D, PHE191B, PHE191D, PHE76B, PHE76D, PRO118B, PRO118D, SER115B, SER115D, SER71B, SER71D, SER79B, SER79D, THR77B, THR77D, VAL72B, VAL72D, VAL74B, VAL74D, VAL88B, VAL88D
• C-D: ALA24C, ALA24D, ALA40C, ALA40D, ALA41C, ALA41D, ALA46C, ALA46D, ALA47C, ALA47D, ALA51C, ALA51D, ALA84D, ARG196C, ARG196D, ARG35D, ARG45C, ARG45D, ARG82C, ARG82D, ASN189C, ASN189D, ASN195C, ASN195D, ASN202D, ASN31D, ASN37C, ASN37D, ASN55C, ASN55D, ASN75C, ASN75D, ASP61C, ASP61D, ASP87D, GLN42C, GLN42D, GLN60C, GLN60D, GLU32C, GLU32D, GLU52C, GLU52D, GLU54C, GLU54D, GLU68C, GLU68D, GLU73C, GLU73D, GLU78C, GLU78D, GLU90D, GLY57C, GLY57D, HIS199D, ILE188C, ILE188D, ILE198D, ILE49C, ILE49D, ILE62C, ILE62D, ILE63C, ILE63D, ILE66C, ILE66D, LEU22C, LEU22D, LEU33C, LEU33D, LEU38C, LEU38D, LEU44C, LEU44D, LEU58C, LEU58D, LEU67C, LEU67D, LEU80C, LEU80D, LEU81C, LEU81D, LYS186C, LYS186D, LYS50C, LYS50D, LYS65C, LYS65D, LYS69C, LYS69D, LYS70C, LYS70D, MET17C, MET17D, MET20C, MET20D, MET26C, MET26D, MET64C, MET64D, MET83C, MET83D, PHE191C, PHE191D, PHE30C, PHE30D, PHE48C, PHE48D, PHE76C, PHE76D, PRO21C, PRO21D, PRO28C, PRO28D, PRO56C, PRO56D, SER16C, SER16D, SER193D, SER19C, SER19D, SER39C, SER39D, SER71C, SER71D, SER79C, SER79D, THR43C, THR43D, THR59C, THR59D, THR77C, THR77D, TYR170D, TYR23C, TYR23D, TYR27C, TYR27D, TYR91D, VAL18C, VAL18D, VAL192C, VAL192D, VAL25C, VAL25D, VAL29C, VAL29D, VAL36C, VAL36D, VAL72C, VAL72D, VAL74C, VAL74D
• C-E: ALA135C, ALA137C, ALA262E, ALA271E, ARG124C, ARG264E, ASN146C, ASP133C, ASP143C, ASP176C, ASP267E, GLN129C, GLU140C, GLU265E, GLU268E, ILE131C, ILE134C, ILE138C, LEU110C, LEU114C, LEU128C, LEU141C, LEU142C, LEU178C, LEU197C, LEU266E, LEU269E, LEU273E, LYS132C, LYS139C, LYS164C, LYS169C, LYS172C, LYS179C, MET270E, PHE127C, PHE167C, PHE174C, PHE182C, SER136C, SER171C, SER173C, SER175C, SER272E, THR130C, THR177C, THR263E, TYR170C, VAL125C, VAL168C