3RNM

the crystal structure of the subunit binding of human dihydrolipoamide transacylase (e2b) bound to human dihydrolipoamide dehydrogenase (e3)

• Total interactions analyzed: 15
• Total true interactions: 8
• Strongest Interaction:
  • Chains: A-E
  • Int. Res.: 46
  • Norm. En. per Res.: -4.071
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-198.4872	-77.5444	-1053.26	-1329.2916	338	44	31	42956	21	104	116
A-C	-16.205	-21.3187	-23.8284	-61.3522	45	4	0	1775	3	35	35
A-E	-33.6417	-67.8598	-85.7631	-187.2646	46	4	0	4113	5	20	18
B-C	0.0	24.2233	-4.5122	19.7111	15	0	0	286	0	6	6
B-E	0.0	10.9368	-29.8169	-18.8801	35	1	0	1413	0	11	9
C-D	-201.7878	-23.6123	-1041.09	-1266.4901	340	40	29	42684	21	106	117
C-F	0.0	8.0735	-26.9019	-18.8284	31	0	0	1283	1	11	9
D-F	-19.8118	-64.9509	-84.2067	-168.9694	45	2	0	4063	4	17	19

Interface residues

• A-B: ALA21A, ALA21B, ALA22A, ALA22B, ALA25A, ALA25B, ALA26A, ALA26B, ALA328A, ALA328B, ALA331A, ALA331B, ALA346A, ALA346B, ALA365A, ALA365B, ALA389A, ALA389B, ALA390A, ALA390B, ALA394A, ALA394B, ALA398A, ALA398B, ALA425A, ALA425B, ALA432A, ALA432B, ALA433A, ALA433B, ALA435A, ALA435B, ALA440A, ALA440B, ALA446A, ALA446B, ALA451A, ALA451B, ALA458A, ALA458B, ALA55A, ALA55B, ALA66A, ALA66B, ALA72A, ALA72B, ALA95A, ALA95B, ALA98A, ALA98B, ARG393A, ARG393B, ARG447A, ARG447B, ARG460A, ARG460B, ARG74A, ARG74B, ARG82A, ARG82B, ASN110A, ASN110B, ASN391A, ASN391B, ASN397A, ASN397B, ASN430A, ASN430B, ASN463A, ASN463B, ASN473A, ASN473B, ASN58A, ASN58B, ASN59A, ASN59B, ASN84A, ASN84B, ASP333A, ASP333B, ASP350A, ASP350B, ASP399A, ASP399B, ASP444A, ASP444B, ASP70A, ASP70B, ASP86A, ASP86B, CYS353A, CYS353B, CYS442A, CYS442B, CYS449A, CYS449B, CYS45A, CYS45B, CYS50A, CYS50B, GLN109A, GLN109B, GLN27A, GLN27B, GLN91A, GLN91B, GLU192A, GLU192B, GLU332A, GLU332B, GLU334A, GLU334B, GLU340A, GLU340B, GLU363A, GLU363B, GLU427A, GLU427B, GLU431A, GLU431B, GLU437A, GLU437B, GLU443A, GLU443B, GLU457A, GLU457B, GLU461A, GLU461B, GLU77A, GLU77B, GLU80A, GLU80B, GLU90A, GLU90B, GLY102A, GLY102B, GLY29A, GLY29B, GLY345A, GLY345B, GLY424A, GLY424B, GLY426A, GLY426B, GLY439A, GLY439B, GLY469A, GLY469B, GLY49A, GLY49B, GLY75A, GLY75B, HIS105A, HIS105B, HIS329A, HIS329B, HIS348A, HIS348B, HIS361A, HIS361B, HIS450A, HIS450B, HIS452A, HIS452B, HIS61A, HIS61B, HIS64A, HIS64B, HIS67A, HIS67B, ILE103A, ILE103B, ILE23A, ILE23B, ILE336A, ILE336B, ILE337A, ILE337B, ILE349A, ILE349B, ILE358A, ILE358B, ILE445A, ILE445B, ILE472A, ILE472B, ILE51A, ILE51B, ILE76A, ILE76B, LEU106A, LEU106B, LEU200A, LEU200B, LEU28A, LEU28B, LEU327A, LEU327B, LEU434A, LEU434B, LEU436A, LEU436B, LEU455A, LEU455B, LEU464A, LEU464B, LEU46A, LEU46B, LEU56A, LEU56B, LEU57A, LEU57B, LEU83A, LEU83B, LEU85A, LEU85B, LEU99A, LEU99B, LYS111A, LYS111B, LYS24A, LYS24B, LYS330A, LYS330B, LYS395A, LYS395B, LYS470A, LYS470B, LYS54A, LYS54B, LYS69A, LYS69B, LYS87A, LYS87B, LYS92A, LYS92B, LYS97A, LYS97B, MET428A, MET428B, MET65A, MET65B, MET78A, MET78B, MET88A, MET88B, MET89A, MET89B, PHE107A, PHE107B, PHE386A, PHE386B, PHE388A, PHE388B, PHE459A, PHE459B, PHE468A, PHE468B, PHE474A, PHE474B, PHE71A, PHE71B, PRO16A, PRO16B, PRO325A, PRO355A, PRO355B, PRO423A, PRO423B, PRO453A, PRO453B, PRO52A, PRO52B, SER356A, SER356B, SER392A, SER392B, SER441A, SER441B, SER456A, SER456B, SER471A, SER471B, SER53A, SER53B, SER60A, SER60B, SER73A, SER73B, SER79A, SER79B, THR100A, THR100B, THR360A, THR360B, THR396A, THR396B, THR400A, THR400B, THR454A, THR454B, THR94A, THR94B, TRP366A, TRP366B, TYR19A, TYR19B, TYR351A, TYR351B, TYR359A, TYR359B, TYR438A, TYR438B, TYR62A, TYR62B, TYR63A, TYR63B, VAL20A, VAL20B, VAL339B, VAL347A, VAL347B, VAL354A, VAL354B, VAL357A, VAL357B, VAL367A, VAL367B, VAL415A, VAL415B, VAL429A, VAL429B, VAL448A, VAL448B, VAL81A, VAL81B, VAL96A, VAL96B
• A-C: ALA132A, ARG82A, ARG82C, ASN84A, ASP133A, ASP161A, ASP163A, ASP203C, ASP251C, ASP255C, ASP272C, ASP86A, CYS271C, GLN198C, GLU179C, GLU267C, GLU80A, GLU80C, GLU90A, GLY234C, ILE258C, ILE269C, LEU85A, LYS175A, LYS176A, LYS180C, LYS232C, LYS236C, LYS238C, LYS248A, LYS249C, LYS253C, LYS265C, LYS69C, LYS87A, LYS97A, MET89A, SER93A, THR164A, THR205C, THR270C, THR94A, VAL204C, VAL256C, VAL268C
• A-E: ALA112E, ALA115E, ALA440A, ALA446A, ARG117E, ARG138E, ARG414A, ARG447A, ASN118E, ASN146E, ASP136E, ASP143E, ASP413A, ASP444A, CYS442A, GLN409A, GLU122E, GLU142E, GLU437A, GLU443A, GLY134E, GLY439A, ILE139E, ILE445A, LEU111E, LEU119E, LEU140E, LEU145E, LEU416A, LEU434A, LEU436A, LYS135E, LYS141E, LYS382A, LYS410A, PRO114E, SER133E, SER411A, SER441A, SER467A, THR113E, THR412A, TYR438A, VAL116E, VAL415A, VAL448A
• B-C: ALA266C, ALA72B, GLU267C, GLU77B, GLU80B, GLY264C, ILE258C, ILE269C, LYS238C, LYS265C, LYS69B, MET78B, SER73B, SER79B, VAL268C
• B-E: ALA112E, ALA115E, ALA346B, ALA435B, ALA440B, ARG117E, ARG138E, ARG414B, ARG447B, ASN118E, ASP136E, ASP444B, GLU122E, GLU340B, GLU437B, GLU443B, GLY344B, GLY345B, GLY439B, HIS348B, ILE139E, ILE445B, LEU111E, LEU140E, LEU434B, LEU436B, LYS135E, MET121E, PRO114E, SER441B, THR113E, TYR438B, VAL116E, VAL347B, VAL448B
• C-D: ALA21C, ALA21D, ALA22C, ALA22D, ALA25C, ALA25D, ALA26C, ALA26D, ALA328C, ALA328D, ALA331C, ALA331D, ALA346C, ALA346D, ALA365C, ALA365D, ALA389C, ALA389D, ALA390C, ALA390D, ALA394C, ALA394D, ALA398C, ALA398D, ALA425C, ALA425D, ALA432C, ALA432D, ALA433C, ALA433D, ALA435C, ALA435D, ALA440C, ALA440D, ALA446C, ALA446D, ALA451C, ALA451D, ALA458C, ALA458D, ALA55C, ALA55D, ALA66C, ALA66D, ALA72C, ALA72D, ALA95C, ALA95D, ALA98C, ALA98D, ARG393C, ARG393D, ARG447C, ARG447D, ARG460C, ARG460D, ARG74C, ARG74D, ARG82C, ARG82D, ASN110C, ASN110D, ASN391C, ASN391D, ASN397C, ASN397D, ASN430C, ASN430D, ASN463C, ASN463D, ASN473C, ASN473D, ASN58C, ASN58D, ASN59C, ASN59D, ASN84C, ASN84D, ASP333C, ASP333D, ASP350C, ASP350D, ASP399C, ASP399D, ASP444C, ASP444D, ASP70C, ASP70D, ASP86C, ASP86D, CYS353C, CYS353D, CYS442C, CYS442D, CYS449C, CYS449D, CYS45C, CYS45D, CYS50C, CYS50D, GLN109C, GLN109D, GLN27C, GLN27D, GLN91C, GLN91D, GLU192C, GLU192D, GLU332C, GLU332D, GLU334C, GLU334D, GLU340C, GLU340D, GLU363C, GLU363D, GLU427C, GLU427D, GLU431C, GLU431D, GLU437C, GLU437D, GLU443C, GLU443D, GLU457C, GLU457D, GLU461C, GLU461D, GLU77C, GLU77D, GLU80C, GLU80D, GLU90C, GLU90D, GLY102C, GLY102D, GLY29C, GLY29D, GLY345C, GLY345D, GLY424C, GLY424D, GLY426C, GLY426D, GLY439C, GLY439D, GLY469C, GLY469D, GLY49C, GLY49D, GLY68C, GLY75C, GLY75D, HIS105C, HIS105D, HIS329C, HIS329D, HIS348C, HIS348D, HIS361C, HIS361D, HIS450C, HIS450D, HIS452C, HIS452D, HIS61C, HIS61D, HIS64C, HIS64D, HIS67C, HIS67D, ILE103C, ILE103D, ILE23C, ILE23D, ILE336C, ILE336D, ILE337C, ILE337D, ILE349C, ILE349D, ILE358C, ILE358D, ILE445C, ILE445D, ILE472C, ILE472D, ILE51C, ILE51D, ILE76C, ILE76D, LEU106C, LEU106D, LEU200C, LEU200D, LEU28C, LEU28D, LEU327C, LEU327D, LEU434C, LEU434D, LEU436C, LEU436D, LEU455C, LEU455D, LEU464C, LEU464D, LEU46C, LEU46D, LEU56C, LEU56D, LEU57C, LEU57D, LEU83C, LEU83D, LEU85C, LEU85D, LEU99C, LEU99D, LYS111C, LYS111D, LYS24C, LYS24D, LYS330C, LYS330D, LYS395C, LYS395D, LYS470C, LYS470D, LYS54C, LYS54D, LYS69C, LYS69D, LYS87C, LYS87D, LYS92C, LYS92D, LYS97C, LYS97D, MET428C, MET428D, MET65C, MET65D, MET78C, MET78D, MET88C, MET88D, MET89C, MET89D, PHE107C, PHE107D, PHE386C, PHE386D, PHE388C, PHE388D, PHE459C, PHE459D, PHE468C, PHE468D, PHE474C, PHE474D, PHE71C, PHE71D, PRO16C, PRO16D, PRO355C, PRO355D, PRO423C, PRO423D, PRO453C, PRO453D, PRO52C, PRO52D, SER356C, SER356D, SER392C, SER392D, SER441C, SER441D, SER456C, SER456D, SER467C, SER471C, SER471D, SER53C, SER53D, SER60C, SER60D, SER73C, SER73D, SER79C, SER79D, THR100C, THR100D, THR360C, THR360D, THR396C, THR396D, THR400C, THR400D, THR454C, THR454D, THR94C, THR94D, TRP366C, TRP366D, TYR19C, TYR19D, TYR351C, TYR351D, TYR359C, TYR359D, TYR438C, TYR438D, TYR62C, TYR62D, TYR63C, TYR63D, VAL20C, VAL20D, VAL339C, VAL339D, VAL347C, VAL347D, VAL354C, VAL354D, VAL357C, VAL357D, VAL367C, VAL367D, VAL415C, VAL415D, VAL429C, VAL429D, VAL448C, VAL448D, VAL81C, VAL81D, VAL96C, VAL96D
• C-F: ALA112F, ALA115F, ALA346C, ALA435C, ALA440C, ARG138F, ARG414C, ARG447C, ASN118F, ASP136F, ASP444C, GLU340C, GLU437C, GLU443C, GLY345C, GLY439C, HIS348C, ILE139F, ILE445C, LEU111F, LEU140F, LEU434C, LEU436C, LYS135F, MET121F, PRO114F, SER441C, THR113F, TYR438C, VAL116F, VAL448C
• D-F: ALA112F, ALA115F, ALA440D, ALA446D, ARG117F, ARG138F, ARG414D, ARG447D, ASN118F, ASN146F, ASP136F, ASP143F, ASP413D, ASP444D, CYS442D, GLN409D, GLU122F, GLU142F, GLU437D, GLU443D, GLY134F, GLY439D, ILE139F, ILE445D, LEU111F, LEU119F, LEU140F, LEU145F, LEU416D, LEU434D, LEU436D, LYS135F, LYS141F, LYS382D, LYS410D, PRO114F, SER133F, SER411D, SER441D, SER467D, THR113F, THR412D, TYR438D, VAL116F, VAL448D