3RL0

truncated snare complex with complexin (p1)

• Total interactions analyzed: 780
• Total true interactions: 142
• Strongest Interaction:
  • Chains: Q-k
  • Int. Res.: 25
  • Norm. En. per Res.: -4.876
• Hub Node: C(12)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-9.4096	0.0	-203.211	-212.6206	72	17	9	8705	0	17	17
A-C	-6.8501	0.0	-4.9891	-11.8392	26	1	0	475	0	1	0
A-D	-21.3138	-84.4914	-135.351	-241.1562	70	3	8	7061	5	25	14
A-G	0.0	0.0	-0.1679	-0.1679	4	0	0	31	0	0	0
A-K	0.0	0.0	-0.0296	-0.0296	6	0	0	6	0	3	9
A-L	0.0	0.0	-0.1168	-0.1168	7	0	0	42	0	2	6
A-O	-4.3516	-54.899	-19.9057	-79.1563	19	6	0	1143	3	6	4
A-P	0.0	0.0	-0.6806	-0.6806	11	0	0	133	0	0	0
A-g	-6.0398	-29.4691	-51.3203	-86.8291	24	2	1	2337	0	13	14
B-C	0.0	-55.3817	-258.342	-313.7237	119	12	15	12237	3	40	55
B-D	-13.4669	0.0	-36.9212	-50.3881	53	1	0	2500	4	9	9
B-O	0.0	0.0	-0.0025	-0.0025	3	0	0	7	0	0	0
B-f	0.0	0.0	-0.6123	-0.6123	6	0	0	85	0	0	0
B-g	-16.9736	-13.5753	-41.254	-71.8029	32	3	1	1798	1	12	11
C-D	-43.3623	-84.0938	-228.639	-356.0951	118	20	5	11311	5	29	39
C-G	0.0	0.0	-0.2613	-0.2613	9	0	0	74	0	8	7
C-H	0.0	0.0	-0.0735	-0.0735	5	0	0	37	0	0	0
C-I	0.0	0.0	-5.6158	-5.6158	8	1	0	299	0	4	2
C-O	0.0	0.0	-0.0511	-0.0511	4	0	0	11	0	1	2
C-e	0.0	1.9983	-3.7222	-1.7239	7	0	0	196	0	5	3
C-f	0.0	0.0	-0.0887	-0.0887	3	0	0	10	0	1	1
D-G	-8.5111	-5.1289	-8.1069	-21.7469	14	1	0	480	0	8	5
D-H	0.0	-37.6022	-25.1204	-62.7225	20	1	1	1275	2	9	5
D-I	0.0	0.0	-0.9834	-0.9834	10	0	0	159	0	2	4
D-K	0.0	0.0	-0.099	-0.099	2	0	0	13	0	2	0
D-L	0.0	-12.3279	-16.37	-28.6979	19	0	0	720	0	8	6
D-O	0.0	34.9905	-50.1645	-15.174	26	3	0	2201	0	10	17
D-P	0.0	0.0	-6.1418	-6.1418	13	0	0	445	0	6	7
E-F	-9.1125	0.0	-189.078	-198.1905	71	14	9	8295	0	16	17
E-G	-9.2446	0.0	-5.1807	-14.4253	25	2	0	530	0	1	0
E-H	-29.9704	-88.9417	-138.705	-257.6171	67	2	8	7033	5	25	14
E-K	-7.3109	-44.3434	7.246	-44.4082	15	3	0	535	3	6	3
E-L	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
E-h	0.0	-21.2911	-34.0281	-55.3192	24	1	0	1971	1	13	14
F-G	0.0	-78.8986	-276.531	-355.4296	129	17	15	12989	5	41	59
F-H	0.0	0.0	-22.0996	-22.0996	48	2	0	1945	0	6	7
F-N	-4.7996	-16.8012	-11.1271	-32.7279	56	18	0	3087	3	28	31
F-O	-16.8464	26.9179	-39.205	-29.1335	35	2	0	1635	4	23	29
F-h	0.0	-19.7142	-29.4442	-49.1584	31	2	0	1631	1	13	11
F-j	0.0	-15.9654	-7.6895	-23.6549	24	0	0	570	1	17	16
G-H	-38.8089	-69.0517	-238.813	-346.6737	120	18	5	11755	5	29	37
G-K	0.0	0.0	-1.1534	-1.1534	6	0	0	77	0	4	3
G-N	-15.894	24.3386	-64.9165	-56.4719	49	4	0	2644	2	28	34
G-O	-6.2067	18.7016	30.2803	42.7753	44	25	0	1831	3	29	32
H-K	0.0	29.5999	-55.121	-25.5211	29	8	0	2380	0	9	18
H-L	0.0	0.0	-1.5579	-1.5579	7	0	0	194	0	5	7
I-J	-8.4692	-12.9105	-166.73	-188.1097	70	15	6	7717	0	16	17
I-K	-6.1365	0.0	-5.3336	-11.4701	25	0	0	462	0	1	0
I-L	-33.9199	-91.0557	-140.509	-265.4846	69	13	8	7223	8	25	14
I-i	-13.108	-46.3543	-42.5347	-101.997	25	3	1	2095	2	13	14
I-n	-7.5358	0.0	-18.9517	-26.4875	9	2	1	822	0	3	2
J-K	0.0	-87.031	-254.558	-341.589	124	10	17	12437	6	42	53
J-L	0.0	0.0	-25.8005	-25.8005	47	1	0	2035	2	5	8
J-O	0.0	0.0	-0.6207	-0.6207	6	0	0	65	0	5	3
J-P	0.0	-2.555	-7.7499	-10.3048	10	0	0	385	0	5	5
J-i	-5.757	-17.685	-36.3863	-59.8283	31	6	0	1893	1	12	7
J-n	-4.705	-3.8749	-34.3214	-42.9013	40	18	5	3939	0	15	19
K-L	-25.8615	-70.6252	-262.959	-359.4457	122	24	7	12551	3	33	46
K-O	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	0
K-W	0.0	6.389	-6.8332	-0.4442	8	1	0	357	0	5	3
K-d	0.0	0.0	-0.444	-0.444	6	0	0	35	0	1	1
K-n	0.0	0.0	-1.7845	-1.7845	17	0	0	306	0	2	2
L-S	0.0	0.0	-0.148	-0.148	4	0	0	33	0	7	3
L-V	0.0	-5.3992	-21.1376	-26.5368	12	1	0	942	0	2	1
L-W	0.0	0.0	-5.9073	-5.9073	9	0	0	234	0	2	2
L-n	0.0	-6.7638	-64.4611	-71.225	46	11	4	3347	0	20	19
M-N	-12.0404	-11.9107	-174.998	-198.9491	72	9	8	8017	0	16	17
M-O	-5.2285	0.0	-7.3175	-12.546	26	1	0	607	0	2	0
M-P	-19.32	-84.307	-132.925	-236.552	70	4	8	6975	5	25	14
M-h	0.0	0.0	-0.0068	-0.0068	2	0	0	7	0	0	1
M-j	0.0	-38.7293	-34.5218	-73.2511	23	5	1	1850	1	13	14
N-O	0.0	-60.0439	-281.019	-341.0629	119	12	16	12993	6	42	55
N-P	0.0	0.0	-25.5114	-25.5114	46	3	0	1884	0	6	7
N-h	0.0	-10.1852	-8.2919	-18.477	20	1	0	445	1	14	9
N-j	0.0	-19.266	-44.1324	-63.3984	30	1	0	1667	1	12	6
O-P	-15.9227	-68.7098	-237.009	-321.6415	118	6	5	11374	4	31	42
P-n	0.0	0.0	-0.0012	-0.0012	4	0	0	3	0	0	0
Q-R	-9.77	-0.9309	-202.581	-213.2818	74	14	9	8623	0	16	17
Q-S	-6.6731	0.0	-4.0476	-10.7207	23	1	0	525	0	2	0
Q-T	-29.7037	-87.4367	-142.472	-259.6124	68	3	8	7143	5	25	15
Q-W	0.0	0.0	-0.2945	-0.2945	2	0	0	36	0	0	0
Q-X	0.0	0.0	-0.0008	-0.0008	2	0	0	2	0	0	1
Q-b	0.0	0.0	-0.034	-0.034	4	0	0	25	0	1	6
Q-e	-10.599	-45.6914	-0.4978	-56.7883	13	3	0	505	3	6	3
Q-f	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	0
Q-k	-15.0417	-56.1538	-50.7055	-121.9009	25	6	1	2419	3	13	14
R-S	0.0	-79.2735	-244.008	-323.2815	126	12	15	11951	5	42	54
R-T	0.0	0.0	-26.481	-26.481	49	2	0	2171	0	6	7
R-k	0.0	-20.4107	-42.9373	-63.348	33	1	0	2002	1	12	11
S-T	-50.3836	-85.5734	-243.895	-379.852	120	32	5	11975	5	30	39
S-W	0.0	3.1223	-22.3524	-19.2301	22	2	1	1649	0	15	18
S-X	0.0	0.0	-0.1067	-0.1067	4	0	0	37	0	0	0
S-Y	0.0	0.0	-2.0093	-2.0093	7	0	0	233	0	2	2
S-e	0.0	0.0	-1.4473	-1.4473	6	0	0	100	0	5	3
T-W	-38.221	1.1773	31.5569	-5.4867	20	9	0	846	0	9	8
T-X	-9.3817	-40.6982	-33.4142	-83.4941	21	10	1	1758	1	9	5
T-Y	0.0	0.0	-0.6354	-0.6354	10	0	0	114	0	2	4
T-a	0.0	0.0	-0.01	-0.01	2	0	0	3	0	1	0
T-b	0.0	-13.1801	-15.6127	-28.7928	15	3	0	647	0	7	5
T-e	0.0	30.3804	-54.1414	-23.761	29	4	0	2316	0	9	18
T-f	0.0	0.0	-1.4162	-1.4162	7	0	0	172	0	5	7
U-V	-9.0868	0.0	-181.947	-191.0338	72	17	8	8295	0	16	16
U-W	-11.3473	0.0	-5.3927	-16.74	23	1	0	430	0	1	0
U-X	-23.0841	-88.2833	-143.376	-254.7434	70	5	8	7164	6	26	14
U-a	0.0	-46.8113	-24.3405	-71.1518	18	5	0	1081	3	6	4
U-b	0.0	0.0	-1.0303	-1.0303	12	0	0	201	0	0	0
U-l	0.0	-6.2413	-30.5085	-36.7498	24	1	1	1727	0	13	14
V-W	0.0	-71.9298	-249.588	-321.5178	120	10	14	11913	4	40	55
V-X	-3.4695	0.0	-26.9694	-30.4389	53	2	0	2202	2	9	9
V-a	0.0	0.0	-0.0032	-0.0032	2	0	0	5	0	0	0
V-d	-7.0525	-11.0384	-35.8941	-53.985	54	11	0	2958	4	27	31
V-e	-16.4636	33.8405	-51.4664	-34.0895	35	3	0	1905	6	21	29
V-l	-11.3173	-13.8477	-31.5885	-56.7535	30	0	0	1524	1	11	12
V-n	0.0	-12.4986	-8.694	-21.1926	29	2	0	1092	0	21	20
W-X	-42.523	-74.7273	-222.576	-339.8263	117	16	5	11130	5	27	37
W-a	0.0	0.0	-0.0476	-0.0476	4	0	0	8	0	1	2
W-d	-19.5463	46.8514	-66.7338	-39.4287	54	12	0	3224	5	29	38
W-e	-2.6686	24.6242	33.099	55.0545	42	30	0	2241	0	30	35
W-n	0.0	0.0	-0.0492	-0.0492	3	0	0	10	0	1	2
X-a	0.0	33.8974	-47.909	-14.0116	26	3	0	2162	0	10	18
X-b	0.0	0.0	-5.9538	-5.9538	13	0	0	429	0	6	7
Y-Z	-10.3163	-1.7539	-184.039	-196.1091	73	9	9	8033	0	16	15
Y-a	-6.183	0.0	-6.8847	-13.0677	28	1	0	651	0	2	0
Y-b	-29.1717	-88.7485	-146.978	-264.8981	71	3	8	7338	6	25	15
Y-m	0.0	-40.6934	-31.7892	-72.4826	23	1	1	1618	4	12	14
Z-a	0.0	-64.9296	-273.099	-338.0286	119	8	15	12583	5	43	54
Z-b	0.0	0.0	-19.5384	-19.5384	45	1	0	1640	0	5	5
Z-m	0.0	-17.1215	-43.8254	-60.9469	27	0	0	1731	1	12	7
a-b	-20.9305	-78.2339	-266.406	-365.5704	121	11	5	12185	5	32	44
c-d	-7.8244	-11.5384	-173.03	-192.3928	69	11	6	7663	0	16	16
c-e	-5.6114	0.0	-5.7171	-11.3285	25	0	0	484	0	1	0
c-f	-20.001	-89.4029	-131.274	-240.678	68	9	8	6978	7	25	14
c-l	0.0	0.0	-0.0011	-0.0011	2	0	0	3	0	0	1
c-n	0.0	-49.8818	-32.1545	-82.0363	25	0	1	1881	4	13	15
d-e	0.0	-70.8552	-227.13	-297.9852	122	33	16	12627	5	42	54
d-f	0.0	0.0	-24.3405	-24.3405	49	1	0	1987	1	5	8
d-l	-5.1498	-14.4335	-5.27	-24.8532	17	0	0	280	1	13	10
d-n	0.0	-19.6555	-38.8526	-58.5081	28	3	0	1643	1	11	7
e-f	-19.5435	-69.8597	-258.355	-347.7582	118	28	8	12320	4	32	46
h-j	0.0	3.6664	-4.313	-0.6466	8	0	0	396	0	4	4
i-n	0.0	-6.97	-1.6753	-8.6453	7	0	0	184	0	4	5
l-n	0.0	1.8968	-2.2353	-0.3385	6	0	0	270	0	4	4

Interface residues

• A-B: ALA220B, ALA37A, ARG198B, ARG210B, ARG30A, ARG31A, ARG47A, ARG56A, ASN207B, ASN29A, ASN49A, ASP214B, ASP218B, ASP231B, ASP40A, ASP44A, ASP51A, ASP57A, GLN226B, GLN33A, GLN34A, GLN36A, GLN38A, GLN58A, GLU194B, GLU201B, GLU206B, GLU211B, GLU224B, GLU228B, GLU41A, GLU55A, GLY227B, GLY27A, HIS199B, HIS213B, ILE195B, ILE202B, ILE203B, ILE209B, ILE230B, ILE233B, ILE45A, LEU205B, LEU212B, LEU222B, LEU26A, LEU32A, LEU54A, LEU60A, LYS204B, LYS52A, LYS59A, MET215B, MET217B, MET219B, MET229B, MET46A, PHE216B, SER200B, SER208B, SER225B, SER28A, THR197B, THR35A, VAL223B, VAL39A, VAL42A, VAL43A, VAL48A, VAL50A, VAL53A
• A-C: ALA42C, ARG56A, ASN49A, ASP51C, GLN36A, GLN53C, GLN56C, GLY43C, GLY54C, LEU32A, LEU47C, LEU50C, LEU57C, LEU60A, MET32C, MET46A, MET49C, SER25C, SER39C, THR29C, THR35A, THR46C, VAL36C, VAL39A, VAL42A, VAL53A
• A-D: ALA164D, ALA37A, ARG161D, ARG176D, ARG180D, ARG31A, ARG47A, ARG56A, ASN159D, ASN169D, ASN175D, ASN29A, ASN49A, ASP147D, ASP166D, ASP172D, ASP179D, ASP40A, ASP44A, ASP51A, ASP57A, GLN174D, GLN177D, GLN33A, GLN34A, GLN36A, GLN38A, GLN58A, GLU143D, GLU148D, GLU151D, GLU170D, GLU41A, GLU55A, GLY155D, GLY158D, GLY168D, GLY27A, HIS162D, ILE156D, ILE157D, ILE171D, ILE178D, ILE181D, ILE45A, LEU150D, LEU160D, LEU165D, LEU26A, LEU32A, LEU54A, LEU60A, LYS52A, LYS59A, MET146D, MET163D, MET167D, MET182D, MET46A, SER154D, SER28A, THR173D, THR35A, VAL153D, VAL39A, VAL42A, VAL43A, VAL48A, VAL50A, VAL53A
• A-G: ARG30G, GLN34A, GLN34G, GLN38A
• A-K: ALA37A, ASP51K, ASP58K, GLN33A, GLU41A, GLU62K
• A-L: ASN169L, ASP166L, GLU170L, GLU41A, LEU165L, LYS52A, VAL48A
• A-O: ALA42O, ARG30A, ARG31A, ARG45O, ASN29A, ASP41O, GLN34A, GLN34O, GLU37O, GLU38O, GLY27A, GLY43O, ILE44O, LEU26A, LEU33O, LYS40O, SER28A, SER39O, VAL36O
• A-P: ARG30A, ARG31A, ASN149P, ASN159P, GLN152P, GLY27A, ILE156P, LEU160P, LEU26A, MET163P, SER28A
• A-g: ARG47A, ARG56A, ARG59g, ARG63g, ARG67g, ASP51A, ASP57A, ASP68g, GLN58A, GLN64g, GLU55A, GLU56g, GLU60g, GLY65g, ILE66g, LEU54A, LEU60A, LYS59A, LYS69g, MET46A, TYR70g, VAL50A, VAL53A, VAL62g
• B-C: ALA18C, ALA191B, ALA220B, ALA22C, ALA240B, ALA247B, ALA42C, ALA74C, ARG17C, ARG198B, ARG210B, ARG232B, ARG246B, ARG30C, ARG31C, ARG45C, ARG59C, ASN207B, ASN236B, ASN65C, ASN68C, ASN77C, ASP19C, ASP214B, ASP218B, ASP231B, ASP23C, ASP242B, ASP41C, ASP51C, ASP58C, ASP70C, GLN15C, GLN20C, GLN226B, GLN34C, GLN53C, GLN56C, GLN69C, GLU196B, GLU201B, GLU206B, GLU211B, GLU224B, GLU228B, GLU234B, GLU238B, GLU245B, GLU24C, GLU27C, GLU37C, GLU38C, GLU52C, GLU55C, GLU61C, GLU62C, GLU73C, GLU75C, GLY227B, GLY43C, GLY54C, GLY63C, HIS199B, HIS213B, HIS239B, HIS66C, ILE195B, ILE202B, ILE203B, ILE209B, ILE230B, ILE233B, ILE44C, ILE67C, LEU192B, LEU205B, LEU212B, LEU21C, LEU222B, LEU26C, LEU33C, LEU35C, LEU47C, LEU50C, LEU57C, LEU78C, LYS204B, LYS40C, LYS72C, MET14C, MET215B, MET217B, MET219B, MET221B, MET229B, MET32C, MET49C, MET64C, MET71C, PHE216B, SER200B, SER208B, SER225B, SER249B, SER25C, SER28C, SER39C, THR197B, THR29C, THR46C, TYR235B, TYR243B, VAL223B, VAL237B, VAL241B, VAL244B, VAL248B, VAL36C, VAL60C
• B-D: ALA164D, ALA185D, ALA191B, ALA220B, ALA240B, ARG142D, ARG161D, ARG198B, ASN159D, ASN175D, ASN188D, ASN236B, ASP147D, GLN174D, GLN226B, GLU143D, GLU148D, GLU234B, GLY139D, HIS162D, HIS199B, HIS213B, ILE157D, ILE171D, ILE178D, ILE181D, ILE192D, ILE195B, ILE202B, ILE209B, ILE230B, ILE233B, LEU150D, LEU160D, LEU165D, LEU205B, LEU212B, LEU222B, LYS189D, MET146D, MET163D, MET167D, MET182D, MET215B, MET219B, PHE216B, SER154D, SER208B, VAL153D, VAL223B, VAL237B, VAL241B, VAL244B
• B-O: ARG198B, ILE44O, LYS40O
• B-f: ALA191B, ALA199f, GLN197f, LEU192B, SER193B, THR200f
• B-g: ARG210B, ARG232B, ARG48g, ARG59g, ARG63g, ARG67g, ASN236B, ASP214B, ASP218B, GLN226B, GLU211B, GLU56g, GLU58g, GLU60g, HIS213B, ILE233B, ILE66g, LEU212B, LEU222B, LYS51g, LYS69g, MET215B, MET217B, MET219B, MET221B, MET229B, PHE216B, SER225B, TYR235B, TYR52g, TYR70g, VAL62g
• C-D: ALA141D, ALA164D, ALA185D, ALA18C, ALA195D, ALA199D, ALA22C, ALA42C, ALA74C, ARG142D, ARG16C, ARG176D, ARG17C, ARG180D, ARG191D, ARG198D, ARG30C, ARG31C, ARG45C, ARG59C, ASN144D, ASN149D, ASN159D, ASN169D, ASN175D, ASN188D, ASN196D, ASN65C, ASN68C, ASP147D, ASP166D, ASP186D, ASP193D, ASP19C, ASP23C, ASP41C, ASP51C, ASP58C, ASP70C, GLN152D, GLN15C, GLN174D, GLN177D, GLN20C, GLN34C, GLN53C, GLN56C, GLN69C, GLU143D, GLU145D, GLU148D, GLU151D, GLU170D, GLU183D, GLU194D, GLU24C, GLU27C, GLU37C, GLU38C, GLU52C, GLU55C, GLU61C, GLU62C, GLU73C, GLU75C, GLY139D, GLY155D, GLY158D, GLY168D, GLY43C, GLY54C, GLY63C, HIS162D, HIS66C, ILE156D, ILE157D, ILE171D, ILE178D, ILE181D, ILE192D, ILE44C, ILE67C, LEU150D, LEU160D, LEU165D, LEU21C, LEU26C, LEU33C, LEU35C, LEU47C, LEU50C, LEU57C, LYS184D, LYS189D, LYS40C, LYS72C, LYS76C, LYS79C, MET146D, MET163D, MET167D, MET182D, MET32C, MET49C, MET64C, MET71C, SER154D, SER187D, SER25C, SER28C, SER39C, THR173D, THR190D, THR29C, THR46C, VAL153D, VAL36C, VAL60C
• C-G: ARG16G, ASP19G, ASP23G, ASP51C, GLN15G, GLU12G, ILE44C, LYS40C, VAL48C
• C-H: ARG142H, GLY139H, ILE44C, LEU47C, LYS40C
• C-I: ARG30I, ASN65C, ASN68C, GLN34I, GLN69C, GLU61C, LYS72C, LYS76C
• C-O: GLU37C, GLU52O, LEU33C, VAL48O
• C-e: ARG8C, ASN77e, GLU10C, GLU75e, LEU78e, LYS76e, LYS79e
• C-f: ALA199f, MET14C, THR200f
• D-G: ALA22G, ARG161D, ARG30G, ASN159D, ASP19G, ASP23G, GLU27G, GLY155D, GLY158D, HIS162D, ILE156D, ILE157D, LEU26G, SER154D
• D-H: ALA141H, ALA164D, ARG142H, ARG161D, ASN144H, ASN149H, ASN159D, ASN169D, ASP166D, GLU143H, GLU145H, GLU148H, GLY139H, GLY158D, HIS162D, LEU165D, MET146H, MET163D, MET167D, SER140H
• D-I: ARG176D, ARG180D, ARG191D, ARG30I, GLN34I, GLN38I, GLU41I, ILE45I, LYS184D, VAL42I
• D-K: ARG161D, ASP51K
• D-L: ARG161D, ARG161L, ARG176D, ASN159L, ASN169D, ASP166D, ASP166L, ASP172D, GLN174D, GLU170D, GLU170L, GLY158L, GLY168D, HIS162L, ILE171D, LEU165D, LEU165L, MET163L, THR173D
• D-O: ALA42O, ARG45O, ASN144D, ASN149D, ASP147D, ASP41O, ASP51O, GLN152D, GLU143D, GLU145D, GLU148D, GLU151D, GLU52O, GLY155D, GLY43O, ILE156D, ILE44O, LEU150D, LEU47O, LYS40O, MET146D, MET49O, SER140D, THR46O, VAL153D, VAL48O
• D-P: ALA141D, ALA164P, ASN144D, ASN159P, ASP147D, ASP166P, GLU143D, GLU148D, GLY158P, HIS162P, MET163P, MET167P, SER140D
• E-F: ALA220F, ALA37E, ARG198F, ARG210F, ARG30E, ARG31E, ARG47E, ARG56E, ASN207F, ASN29E, ASN49E, ASP214F, ASP218F, ASP231F, ASP40E, ASP44E, ASP51E, ASP57E, GLN226F, GLN33E, GLN34E, GLN36E, GLN38E, GLN58E, GLU194F, GLU201F, GLU206F, GLU211F, GLU224F, GLU228F, GLU41E, GLU55E, GLY227F, GLY27E, HIS199F, HIS213F, ILE202F, ILE203F, ILE209F, ILE230F, ILE233F, ILE45E, LEU205F, LEU212F, LEU222F, LEU26E, LEU32E, LEU54E, LEU60E, LYS204F, LYS52E, LYS59E, MET215F, MET217F, MET219F, MET229F, MET46E, PHE216F, SER200F, SER208F, SER225F, SER28E, THR197F, THR35E, VAL223F, VAL39E, VAL42E, VAL43E, VAL48E, VAL50E, VAL53E
• E-G: ALA42G, ARG56E, ASN49E, ASP51G, GLN36E, GLN53G, GLN56G, GLY43G, GLY54G, LEU32E, LEU47G, LEU50G, LEU57G, LEU60E, MET32G, MET46E, MET49G, SER39G, THR29G, THR35E, THR46G, VAL36G, VAL39E, VAL42E, VAL53E
• E-H: ALA164H, ALA37E, ARG161H, ARG176H, ARG180H, ARG31E, ARG47E, ARG56E, ASN159H, ASN169H, ASN175H, ASN29E, ASN49E, ASP147H, ASP166H, ASP172H, ASP179H, ASP40E, ASP44E, ASP51E, ASP57E, GLN174H, GLN177H, GLN34E, GLN36E, GLN38E, GLN58E, GLU143H, GLU148H, GLU151H, GLU170H, GLU41E, GLU55E, GLY155H, GLY158H, GLY168H, HIS162H, ILE156H, ILE157H, ILE171H, ILE178H, ILE181H, ILE45E, LEU150H, LEU160H, LEU165H, LEU32E, LEU54E, LEU60E, LYS52E, LYS59E, MET146H, MET163H, MET167H, MET182H, MET46E, SER154H, SER28E, THR173H, THR35E, VAL153H, VAL39E, VAL42E, VAL43E, VAL48E, VAL50E, VAL53E
• E-K: ALA42K, ARG30E, ARG31E, ARG45K, ASP41K, GLN34K, GLU37K, GLU38K, GLY27E, GLY43K, ILE44K, LYS40K, SER28E, SER39K, VAL36K
• E-L: ARG31E, MET163L
• E-h: ARG47E, ARG56E, ARG59h, ARG63h, ARG67h, ASP51E, ASP57E, GLN58E, GLN64h, GLU55E, GLU56h, GLU60h, GLY65h, ILE66h, LEU54E, LEU60E, LYS59E, LYS69h, TYR52h, TYR70h, VAL43E, VAL50E, VAL53E, VAL62h
• F-G: ALA18G, ALA191F, ALA220F, ALA22G, ALA240F, ALA247F, ALA42G, ALA74G, ARG16G, ARG17G, ARG198F, ARG210F, ARG232F, ARG246F, ARG30G, ARG31G, ARG45G, ARG59G, ASN207F, ASN236F, ASN65G, ASN68G, ASN77G, ASP19G, ASP214F, ASP218F, ASP231F, ASP23G, ASP242F, ASP250F, ASP41G, ASP51G, ASP58G, ASP70G, GLN15G, GLN20G, GLN226F, GLN34G, GLN53G, GLN56G, GLN69G, GLU10G, GLU13G, GLU196F, GLU201F, GLU206F, GLU211F, GLU224F, GLU228F, GLU234F, GLU238F, GLU245F, GLU24G, GLU27G, GLU37G, GLU38G, GLU52G, GLU55G, GLU61G, GLU62G, GLU73G, GLU75G, GLY227F, GLY43G, GLY54G, GLY63G, HIS199F, HIS213F, HIS239F, HIS66G, ILE195F, ILE202F, ILE203F, ILE209F, ILE230F, ILE233F, ILE44G, ILE67G, LEU11G, LEU192F, LEU205F, LEU212F, LEU21G, LEU222F, LEU26G, LEU33G, LEU35G, LEU47G, LEU50G, LEU57G, LEU78G, LYS204F, LYS40G, LYS72G, LYS76G, LYS79G, MET14G, MET215F, MET217F, MET219F, MET221F, MET229F, MET32G, MET49G, MET64G, MET71G, PHE216F, SER193F, SER200F, SER208F, SER225F, SER249F, SER25G, SER28G, SER39G, THR197F, THR251F, THR29G, THR46G, TYR235F, TYR243F, VAL223F, VAL237F, VAL241F, VAL244F, VAL248F, VAL36G, VAL48G, VAL60G
• F-H: ALA164H, ALA185H, ALA220F, ALA240F, ARG142H, ARG161H, ARG198F, ASN159H, ASN175H, ASN188H, ASP147H, GLN174H, GLN226F, GLU143H, GLU234F, GLY139H, GLY168H, HIS162H, HIS199F, HIS213F, ILE157H, ILE171H, ILE178H, ILE181H, ILE192H, ILE195F, ILE202F, ILE209F, ILE230F, ILE233F, LEU150H, LEU160H, LEU165H, LEU205F, LEU212F, LEU222F, MET146H, MET163H, MET167H, MET215F, MET219F, PHE216F, SER154H, VAL153H, VAL223F, VAL237F, VAL241F, VAL244F
• F-N: ALA220F, ALA220N, ARG210F, ARG210N, ARG232F, ARG232N, ASN207F, ASN207N, ASP214F, ASP214N, ASP218F, ASP218N, ASP231F, GLN226F, GLU196F, GLU196N, GLU206F, GLU206N, GLU211N, GLU224F, GLU224N, GLU228F, GLU228N, GLY227F, HIS199F, HIS199N, HIS213F, HIS213N, HIS239F, ILE195N, ILE202N, ILE203F, ILE203N, ILE230F, ILE233F, LEU192F, LEU192N, LEU222F, LYS204N, MET215N, MET217F, MET217N, MET219F, MET219N, MET221F, MET221N, MET229F, PHE216F, PHE216N, SER193N, SER200N, SER208N, SER225F, SER225N, THR197N, TYR235F
• F-O: ALA220F, ARG17O, ARG232F, ARG246F, ARG31O, ARG8O, ASN236F, ASN9O, ASP231F, ASP242F, GLN20O, GLU10O, GLU13O, GLU224F, GLU228F, GLU234F, GLU238F, GLU245F, GLU24O, GLU27O, GLY227F, HIS213F, HIS239F, ILE230F, ILE233F, LEU11O, LEU21O, LEU35O, MET14O, MET217F, MET221F, SER25O, SER28O, TYR235F, VAL241F
• F-h: ARG210F, ARG232F, ARG48h, ARG59h, ARG63h, ASP214F, ASP218F, GLN226F, GLU211F, GLU56h, GLU60h, GLY65h, HIS213F, ILE233F, ILE66h, LEU212F, LEU222F, LYS49h, LYS51h, LYS69h, MET215F, MET217F, MET219F, MET221F, MET229F, PHE216F, SER225F, TYR235F, TYR52h, TYR70h, VAL62h
• F-j: ALA61j, ARG210F, ARG48j, ARG59j, ARG63j, ASN207F, ASP214F, ASP218F, GLU196F, GLU211F, GLU58j, GLY65j, ILE203F, ILE66j, LYS204F, LYS51j, LYS54j, LYS69j, SER193F, SER200F, THR197F, TYR52j, TYR70j, VAL62j
• G-H: ALA141H, ALA164H, ALA185H, ALA18G, ALA195H, ALA199H, ALA22G, ALA42G, ALA74G, ARG142H, ARG16G, ARG176H, ARG17G, ARG180H, ARG191H, ARG198H, ARG30G, ARG31G, ARG45G, ARG59G, ASN144H, ASN149H, ASN159H, ASN169H, ASN175H, ASN188H, ASN196H, ASN65G, ASN68G, ASP147H, ASP166H, ASP172H, ASP186H, ASP193H, ASP19G, ASP23G, ASP41G, ASP51G, ASP58G, ASP70G, GLN152H, GLN15G, GLN174H, GLN177H, GLN197H, GLN20G, GLN34G, GLN53G, GLN56G, GLN69G, GLU143H, GLU145H, GLU148H, GLU151H, GLU170H, GLU183H, GLU194H, GLU24G, GLU27G, GLU37G, GLU38G, GLU52G, GLU55G, GLU61G, GLU62G, GLU73G, GLU75G, GLY139H, GLY155H, GLY158H, GLY168H, GLY43G, GLY54G, GLY63G, HIS162H, HIS66G, ILE156H, ILE157H, ILE171H, ILE178H, ILE181H, ILE192H, ILE44G, ILE67G, LEU150H, LEU160H, LEU165H, LEU21G, LEU26G, LEU33G, LEU35G, LEU47G, LEU50G, LEU57G, LYS184H, LYS189H, LYS40G, LYS72G, LYS79G, MET146H, MET163H, MET167H, MET182H, MET32G, MET49G, MET64G, MET71G, SER154H, SER187H, SER25G, SER28G, SER39G, THR173H, THR190H, THR29G, THR46G, VAL153H, VAL36G, VAL48G, VAL60G
• G-K: ASP51K, GLU37G, GLU52K, GLU55K, LEU33G, VAL48K
• G-N: ALA220N, ALA42G, ARG16G, ARG17G, ARG210N, ARG232N, ARG31G, ARG45G, ARG8G, ASN236N, ASN9G, ASP214N, ASP218N, ASP231N, ASP23G, ASP242N, GLN20G, GLN34G, GLU10G, GLU12G, GLU13G, GLU206N, GLU224N, GLU228N, GLU234N, GLU238N, GLU24G, GLU27G, GLU38G, GLY227N, HIS199N, HIS213N, HIS239N, ILE203N, ILE230N, ILE233N, LEU11G, LEU21G, LEU222N, LEU35G, MET14G, MET217N, MET221N, MET229N, MET49G, SER225N, SER25G, SER28G, TYR235N
• G-O: ALA42G, ALA42O, ARG16G, ARG16O, ARG17O, ARG31G, ARG31O, ARG45G, ARG45O, ARG59G, ARG8O, ASN9O, ASP41G, GLN20G, GLN20O, GLN34G, GLN34O, GLN53G, GLN56G, GLN56O, GLU10O, GLU12O, GLU13O, GLU24O, GLU27G, GLU27O, GLU38G, GLU38O, GLU52G, GLU55G, GLU62G, HIS66G, ILE44G, LEU21O, LEU35G, LEU35O, MET14O, MET49G, MET49O, SER28G, SER28O, THR46G, VAL48G, VAL60G
• H-K: ALA42K, ARG45K, ASN144H, ASN149H, ASP147H, ASP41K, ASP51K, GLN152H, GLN53K, GLU143H, GLU145H, GLU148H, GLU151H, GLU52K, GLU55K, GLY155H, GLY43K, ILE156H, ILE44K, LEU150H, LEU47K, LYS40K, MET146H, MET49K, SER140H, SER154H, THR46K, VAL153H, VAL48K
• H-L: ASN144H, ASN159L, ASP166L, GLU148H, HIS162L, MET163L, SER140H
• I-J: ALA220J, ALA37I, ARG198J, ARG210J, ARG30I, ARG31I, ARG47I, ARG56I, ASN207J, ASN29I, ASN49I, ASP214J, ASP218J, ASP231J, ASP40I, ASP44I, ASP51I, ASP57I, GLN226J, GLN33I, GLN34I, GLN36I, GLN38I, GLN58I, GLU194J, GLU201J, GLU206J, GLU211J, GLU224J, GLU228J, GLU41I, GLU55I, GLY227J, GLY27I, HIS199J, HIS213J, ILE202J, ILE203J, ILE209J, ILE230J, ILE233J, ILE45I, LEU205J, LEU212J, LEU222J, LEU32I, LEU54I, LEU60I, LYS204J, LYS52I, LYS59I, MET215J, MET217J, MET219J, MET229J, MET46I, PHE216J, SER200J, SER208J, SER225J, SER28I, THR197J, THR35I, VAL223J, VAL39I, VAL42I, VAL43I, VAL48I, VAL50I, VAL53I
• I-K: ALA42K, ARG56I, ASN49I, GLN36I, GLN53K, GLN56K, GLY43K, GLY54K, LEU32I, LEU47K, LEU50K, LEU57K, LEU60I, MET32K, MET46I, MET49K, SER25K, SER39K, THR29K, THR35I, THR46K, VAL36K, VAL39I, VAL42I, VAL53I
• I-L: ALA164L, ALA37I, ARG161L, ARG176L, ARG180L, ARG31I, ARG47I, ARG56I, ASN144L, ASN159L, ASN169L, ASN175L, ASN29I, ASN49I, ASP147L, ASP166L, ASP172L, ASP179L, ASP40I, ASP44I, ASP51I, ASP57I, GLN174L, GLN177L, GLN34I, GLN36I, GLN38I, GLN58I, GLU143L, GLU148L, GLU151L, GLU170L, GLU41I, GLU55I, GLY155L, GLY158L, GLY168L, GLY27I, HIS162L, ILE156L, ILE157L, ILE171L, ILE178L, ILE181L, ILE45I, LEU150L, LEU160L, LEU165L, LEU32I, LEU54I, LEU60I, LYS52I, LYS59I, MET146L, MET163L, MET167L, MET182L, MET46I, SER154L, SER28I, THR173L, THR35I, VAL153L, VAL39I, VAL42I, VAL43I, VAL48I, VAL50I, VAL53I
• I-i: ALA61i, ARG47I, ARG56I, ARG59i, ARG63i, ARG67i, ASP51I, ASP57I, ASP68i, GLN58I, GLN64i, GLU55I, GLU56i, GLU60i, GLY65i, ILE66i, LEU54I, LEU60I, LYS59I, LYS69i, TYR70i, VAL43I, VAL50I, VAL53I, VAL62i
• I-n: ARG56I, ASP29n, ASP57I, GLN58I, LEU27n, LEU60I, LYS26n, LYS59I, PRO28n
• J-K: ALA18K, ALA191J, ALA220J, ALA22K, ALA240J, ALA247J, ALA42K, ALA74K, ARG16K, ARG17K, ARG198J, ARG210J, ARG232J, ARG246J, ARG30K, ARG31K, ARG45K, ARG59K, ASN207J, ASN236J, ASN65K, ASN68K, ASN77K, ASP19K, ASP214J, ASP218J, ASP231J, ASP23K, ASP242J, ASP41K, ASP51K, ASP58K, ASP70K, GLN15K, GLN20K, GLN226J, GLN34K, GLN53K, GLN56K, GLN69K, GLU13K, GLU194J, GLU196J, GLU201J, GLU206J, GLU211J, GLU224J, GLU228J, GLU234J, GLU238J, GLU245J, GLU24K, GLU27K, GLU37K, GLU38K, GLU52K, GLU55K, GLU61K, GLU62K, GLU73K, GLU75K, GLY227J, GLY43K, GLY54K, GLY63K, HIS199J, HIS213J, HIS239J, HIS66K, ILE195J, ILE202J, ILE203J, ILE209J, ILE230J, ILE233J, ILE44K, ILE67K, LEU192J, LEU205J, LEU212J, LEU21K, LEU222J, LEU26K, LEU33K, LEU35K, LEU47K, LEU50K, LEU57K, LEU78K, LYS204J, LYS40K, LYS72K, MET14K, MET215J, MET217J, MET219J, MET221J, MET229J, MET32K, MET49K, MET64K, MET71K, PHE216J, SER190J, SER193J, SER200J, SER208J, SER225J, SER25K, SER28K, SER39K, THR197J, THR29K, THR46K, TYR235J, TYR243J, VAL223J, VAL237J, VAL241J, VAL244J, VAL248J, VAL36K, VAL48K, VAL60K
• J-L: ALA164L, ALA185L, ALA220J, ALA240J, ARG161L, ARG198J, ASN159L, ASN175L, ASN188L, ASP147L, GLN174L, GLN226J, GLU143L, GLY139L, GLY168L, HIS162L, HIS199J, HIS213J, ILE157L, ILE171L, ILE178L, ILE181L, ILE192L, ILE195J, ILE202J, ILE209J, ILE230J, ILE233J, LEU150L, LEU160L, LEU165L, LEU205J, LEU212J, LEU222J, MET146L, MET163L, MET167L, MET182L, MET215J, MET219J, PHE216J, SER154L, SER208J, VAL153L, VAL223J, VAL237J, VAL244J
• J-O: ARG246J, ARG30O, ASP23O, ASP242J, GLU238J, LEU26O
• J-P: ALA141P, ARG142P, ARG246J, ASN144P, ASP242J, GLU143P, GLU145P, GLU245J, GLY139P, SER140P
• J-i: ARG210J, ARG232J, ARG48i, ARG59i, ARG63i, ARG67i, ASP214J, ASP218J, GLN226J, GLU211J, GLU224J, GLU228J, GLU56i, GLY227J, HIS213J, ILE230J, ILE66i, LEU212J, LEU222J, LYS69i, MET215J, MET217J, MET219J, MET221J, MET229J, PHE216J, SER225J, TYR52i, TYR70i, VAL223J, VAL62i
• J-n: ALA240J, ALA247J, ALA30n, ALA31n, ALA37n, ALA40n, ALA44n, ARG232J, ARG246J, ARG42n, ASN236J, ASP242J, ASP29n, GLN38n, GLN43n, GLU234J, GLU238J, GLU245J, GLU35n, GLU36n, GLU39n, GLU45n, GLU46n, HIS239J, ILE230J, ILE233J, LEU27n, LEU41n, LYS26n, LYS32n, LYS33n, LYS49n, MET229J, PRO28n, TYR235J, TYR243J, VAL237J, VAL241J, VAL244J, VAL248J
• K-L: ALA141L, ALA164L, ALA185L, ALA18K, ALA195L, ALA199L, ALA22K, ALA42K, ALA74K, ARG142L, ARG16K, ARG176L, ARG180L, ARG191L, ARG198L, ARG30K, ARG31K, ARG45K, ARG59K, ASN144L, ASN149L, ASN159L, ASN169L, ASN175L, ASN188L, ASN196L, ASN65K, ASN68K, ASP147L, ASP166L, ASP172L, ASP179L, ASP186L, ASP193L, ASP19K, ASP23K, ASP41K, ASP51K, ASP58K, ASP70K, GLN152L, GLN174L, GLN177L, GLN197L, GLN20K, GLN34K, GLN53K, GLN56K, GLN69K, GLU143L, GLU145L, GLU148L, GLU151L, GLU170L, GLU183L, GLU194L, GLU24K, GLU27K, GLU37K, GLU38K, GLU52K, GLU55K, GLU61K, GLU62K, GLU73K, GLU75K, GLY139L, GLY155L, GLY158L, GLY168L, GLY43K, GLY54K, GLY63K, HIS162L, HIS66K, ILE156L, ILE157L, ILE171L, ILE178L, ILE181L, ILE192L, ILE44K, ILE67K, LEU150L, LEU160L, LEU165L, LEU21K, LEU26K, LEU33K, LEU35K, LEU47K, LEU50K, LEU57K, LEU78K, LYS184L, LYS189L, LYS40K, LYS72K, LYS76K, LYS79K, MET146L, MET163L, MET167L, MET182L, MET202L, MET32K, MET49K, MET64K, MET71K, SER154L, SER187L, SER25K, SER28K, SER39K, THR173L, THR190L, THR29K, THR46K, VAL153L, VAL36K, VAL48K, VAL60K
• K-O: ARG59K, GLN34O
• K-W: ARG8W, ASN77K, GLU10W, GLU75K, LEU78K, LYS76K, LYS79K, MET14W
• K-d: ASN77K, HIS239d, LYS76K, LYS79K, TYR235d, TYR243d
• K-n: ALA30n, ALA31n, ALA37n, ALA74K, ARG48n, ASP70K, GLN38n, GLU35n, GLU45n, ILE67K, LEU27n, LEU41n, LEU57K, LEU78K, MET64K, MET71K, VAL60K
• L-S: ARG198L, ARG59S, GLU55S, MET202L
• L-V: ALA191V, ALA199L, GLN197L, GLU194V, GLU196V, ILE195V, LEU192V, LYS201L, MET202L, SER193V, THR197V, THR200L
• L-W: ALA199L, ARG198L, ARG8W, GLN15W, GLU10W, LEU11W, LYS201L, MET14W, MET202L
• L-n: ALA185L, ALA195L, ALA199L, ALA30n, ALA31n, ALA37n, ALA40n, ALA44n, ARG180L, ARG198L, ARG42n, ARG48n, ASN188L, ASN196L, ASP179L, ASP186L, ASP193L, ASP29n, GLN177L, GLN197L, GLN38n, GLN43n, GLU183L, GLU35n, GLU36n, GLU39n, GLU45n, GLU47n, ILE178L, ILE181L, ILE192L, LEU27n, LEU41n, LYS184L, LYS189L, LYS201L, LYS26n, LYS32n, LYS33n, LYS51n, MET182L, MET202L, PRO28n, SER187L, THR190L, THR200L
• M-N: ALA220N, ALA37M, ARG198N, ARG210N, ARG30M, ARG31M, ARG47M, ARG56M, ASN207N, ASN29M, ASN49M, ASP214N, ASP218N, ASP231N, ASP40M, ASP44M, ASP51M, ASP57M, GLN226N, GLN33M, GLN34M, GLN36M, GLN38M, GLN58M, GLU194N, GLU201N, GLU206N, GLU211N, GLU224N, GLU228N, GLU41M, GLU55M, GLY227N, HIS199N, HIS213N, ILE195N, ILE202N, ILE203N, ILE209N, ILE230N, ILE233N, ILE45M, LEU205N, LEU212N, LEU222N, LEU26M, LEU32M, LEU54M, LEU60M, LYS204N, LYS52M, LYS59M, MET215N, MET217N, MET219N, MET229N, MET46M, PHE216N, PRO25M, SER200N, SER208N, SER225N, SER28M, THR197N, THR35M, VAL223N, VAL39M, VAL42M, VAL43M, VAL48M, VAL50M, VAL53M
• M-O: ALA42O, ARG56M, ASN49M, ASP51O, GLN36M, GLN53O, GLN56O, GLY43O, GLY54O, LEU32M, LEU47O, LEU50O, LEU57O, LEU60M, MET32O, MET46M, MET49O, SER25O, SER39O, THR29O, THR35M, THR46O, VAL36O, VAL39M, VAL42M, VAL53M
• M-P: ALA164P, ALA37M, ARG161P, ARG176P, ARG180P, ARG31M, ARG47M, ARG56M, ASN159P, ASN169P, ASN175P, ASN29M, ASN49M, ASP147P, ASP166P, ASP172P, ASP179P, ASP40M, ASP44M, ASP51M, ASP57M, GLN174P, GLN177P, GLN34M, GLN36M, GLN38M, GLN58M, GLU143P, GLU148P, GLU151P, GLU170P, GLU41M, GLU55M, GLY155P, GLY158P, GLY168P, GLY27M, HIS162P, ILE156P, ILE157P, ILE171P, ILE178P, ILE181P, ILE45M, LEU150P, LEU160P, LEU165P, LEU32M, LEU54M, LEU60M, LYS52M, LYS59M, MET146P, MET163P, MET167P, MET182P, MET46M, PRO25M, SER140P, SER154P, SER28M, THR173P, THR35M, VAL153P, VAL39M, VAL42M, VAL43M, VAL48M, VAL50M, VAL53M
• M-h: ASN29M, LYS51h
• M-j: ARG47M, ARG56M, ARG59j, ARG63j, ARG67j, ASP51M, ASP57M, ASP68j, GLN58M, GLN64j, GLU55M, GLU60j, ILE66j, LEU54M, LEU60M, LYS59M, LYS69j, MET46M, TYR70j, VAL43M, VAL50M, VAL53M, VAL62j
• N-O: ALA18O, ALA191N, ALA220N, ALA22O, ALA240N, ALA247N, ALA42O, ALA74O, ARG16O, ARG17O, ARG198N, ARG210N, ARG232N, ARG246N, ARG30O, ARG31O, ARG45O, ARG59O, ASN207N, ASN236N, ASN65O, ASN68O, ASP19O, ASP214N, ASP218N, ASP231N, ASP23O, ASP242N, ASP41O, ASP51O, ASP58O, ASP70O, GLN15O, GLN20O, GLN226N, GLN34O, GLN53O, GLN56O, GLN69O, GLU10O, GLU13O, GLU196N, GLU201N, GLU206N, GLU211N, GLU224N, GLU228N, GLU234N, GLU238N, GLU245N, GLU24O, GLU27O, GLU37O, GLU38O, GLU52O, GLU55O, GLU61O, GLU62O, GLU73O, GLY227N, GLY43O, GLY54O, GLY63O, HIS199N, HIS213N, HIS239N, HIS66O, ILE195N, ILE202N, ILE203N, ILE209N, ILE230N, ILE233N, ILE44O, ILE67O, LEU11O, LEU192N, LEU205N, LEU212N, LEU21O, LEU222N, LEU26O, LEU33O, LEU35O, LEU47O, LEU50O, LEU57O, LYS204N, LYS40O, MET14O, MET215N, MET217N, MET219N, MET221N, MET229N, MET32O, MET49O, MET64O, MET71O, PHE216N, SER193N, SER200N, SER208N, SER225N, SER25O, SER28O, SER39O, THR197N, THR29O, THR46O, TYR235N, TYR243N, VAL223N, VAL237N, VAL241N, VAL244N, VAL36O, VAL48O, VAL60O
• N-P: ALA164P, ALA185P, ALA220N, ALA240N, ARG142P, ARG161P, ARG198N, ASN159P, ASN188P, ASP147P, GLN174P, GLN226N, GLU143P, GLY139P, HIS162P, HIS199N, HIS213N, ILE157P, ILE171P, ILE178P, ILE181P, ILE192P, ILE195N, ILE202N, ILE209N, ILE230N, ILE233N, LEU150P, LEU160P, LEU165P, LEU205N, LEU212N, LEU222N, MET146P, MET163P, MET167P, MET182P, MET215N, MET219N, PHE216N, SER154P, SER208N, VAL153P, VAL223N, VAL237N, VAL244N
• N-h: ARG198N, ARG48h, ARG59h, ASN207N, ASP214N, GLU194N, GLU196N, GLU201N, GLU211N, GLU58h, ILE203N, ILE66h, LYS204N, LYS51h, LYS54h, LYS69h, SER193N, SER200N, THR197N, VAL62h
• N-j: ARG210N, ARG232N, ARG59j, ARG63j, ARG67j, ASP214N, ASP218N, GLN226N, GLU211N, GLU224N, GLU228N, GLU56j, GLU60j, GLY227N, HIS213N, ILE66j, LEU212N, LEU222N, LYS69j, MET215N, MET217N, MET219N, MET221N, MET229N, PHE216N, SER225N, TYR52j, TYR70j, VAL223N, VAL62j
• O-P: ALA141P, ALA164P, ALA185P, ALA18O, ALA195P, ALA199P, ALA22O, ALA42O, ALA74O, ARG142P, ARG16O, ARG176P, ARG17O, ARG180P, ARG191P, ARG198P, ARG30O, ARG31O, ARG45O, ARG59O, ASN144P, ASN149P, ASN159P, ASN169P, ASN175P, ASN188P, ASN196P, ASN65O, ASN68O, ASP147P, ASP166P, ASP186P, ASP193P, ASP19O, ASP23O, ASP41O, ASP51O, ASP58O, ASP70O, GLN152P, GLN15O, GLN174P, GLN177P, GLN197P, GLN20O, GLN34O, GLN53O, GLN56O, GLN69O, GLU143P, GLU145P, GLU148P, GLU151P, GLU170P, GLU194P, GLU24O, GLU27O, GLU37O, GLU38O, GLU52O, GLU55O, GLU61O, GLU62O, GLU75O, GLY139P, GLY155P, GLY158P, GLY168P, GLY43O, GLY54O, GLY63O, HIS162P, HIS66O, ILE156P, ILE157P, ILE171P, ILE178P, ILE181P, ILE192P, ILE44O, ILE67O, LEU150P, LEU160P, LEU165P, LEU21O, LEU26O, LEU33O, LEU35O, LEU47O, LEU50O, LEU57O, LEU78O, LYS184P, LYS189P, LYS40O, LYS72O, LYS79O, MET146P, MET163P, MET167P, MET182P, MET202P, MET32O, MET49O, MET64O, MET71O, SER154P, SER187P, SER25O, SER28O, SER39O, THR173P, THR190P, THR29O, THR46O, VAL153P, VAL36O, VAL60O
• P-n: ALA141P, ARG142P, ARG42n, LYS49n
• Q-R: ALA220R, ALA37Q, ARG198R, ARG210R, ARG30Q, ARG31Q, ARG47Q, ARG56Q, ASN207R, ASN29Q, ASN49Q, ASP214R, ASP218R, ASP231R, ASP40Q, ASP44Q, ASP51Q, ASP57Q, GLN226R, GLN33Q, GLN34Q, GLN36Q, GLN38Q, GLN58Q, GLU194R, GLU201R, GLU206R, GLU211R, GLU224R, GLU228R, GLU41Q, GLU55Q, GLY227R, GLY27Q, HIS199R, HIS213R, ILE195R, ILE202R, ILE203R, ILE209R, ILE230R, ILE233R, ILE45Q, LEU205R, LEU212R, LEU222R, LEU26Q, LEU32Q, LEU54Q, LEU60Q, LYS204R, LYS52Q, LYS59Q, MET215R, MET217R, MET219R, MET221R, MET229R, MET46Q, PHE216R, SER193R, SER200R, SER208R, SER225R, SER28Q, THR197R, THR35Q, VAL223R, VAL39Q, VAL42Q, VAL43Q, VAL48Q, VAL50Q, VAL53Q
• Q-S: ALA42S, ARG56Q, ASN49Q, ASP51S, GLN53S, GLN56S, GLY43S, GLY54S, LEU32Q, LEU47S, LEU50S, LEU57S, LEU60Q, MET32S, MET46Q, MET49S, SER39S, THR29S, THR35Q, THR46S, VAL36S, VAL39Q, VAL53Q
• Q-T: ALA164T, ALA37Q, ARG161T, ARG176T, ARG180T, ARG31Q, ARG47Q, ARG56Q, ASN159T, ASN169T, ASN175T, ASN29Q, ASN49Q, ASP147T, ASP166T, ASP172T, ASP179T, ASP40Q, ASP44Q, ASP51Q, ASP57Q, GLN174T, GLN177T, GLN34Q, GLN36Q, GLN38Q, GLN58Q, GLU143T, GLU148T, GLU151T, GLU170T, GLU41Q, GLU55Q, GLY155T, GLY158T, GLY168T, GLY27Q, HIS162T, ILE156T, ILE157T, ILE171T, ILE178T, ILE181T, ILE45Q, LEU150T, LEU160T, LEU165T, LEU32Q, LEU54Q, LEU60Q, LYS52Q, LYS59Q, MET146T, MET163T, MET167T, MET182T, MET46Q, SER154T, SER28Q, THR173T, THR35Q, VAL153T, VAL39Q, VAL42Q, VAL43Q, VAL48Q, VAL50Q, VAL53Q
• Q-W: ARG30W, GLN38Q
• Q-X: ALA141X, ILE45Q
• Q-b: ASN169b, LEU165b, LYS52Q, VAL48Q
• Q-e: ALA42e, ARG31Q, ARG45e, ASP41e, GLU37e, GLU38e, GLY27Q, GLY43e, ILE44e, LYS40e, SER28Q, SER39e, VAL36e
• Q-f: ARG31Q, MET163f
• Q-k: ARG47Q, ARG56Q, ARG59k, ARG63k, ARG67k, ASP51Q, ASP57Q, ASP68k, GLN58Q, GLN64k, GLU55Q, GLU56k, GLU60k, GLY65k, ILE66k, LEU54Q, LEU60Q, LYS59Q, LYS69k, TYR52k, TYR70k, VAL43Q, VAL50Q, VAL53Q, VAL62k
• R-S: ALA18S, ALA191R, ALA220R, ALA22S, ALA240R, ALA247R, ALA42S, ALA74S, ARG17S, ARG198R, ARG210R, ARG232R, ARG246R, ARG31S, ARG45S, ARG59S, ASN207R, ASN236R, ASN65S, ASN68S, ASN77S, ASP19S, ASP214R, ASP218R, ASP231R, ASP23S, ASP242R, ASP250R, ASP41S, ASP51S, ASP58S, ASP70S, GLN15S, GLN20S, GLN226R, GLN34S, GLN53S, GLN56S, GLN69S, GLU10S, GLU13S, GLU196R, GLU201R, GLU206R, GLU211R, GLU224R, GLU228R, GLU234R, GLU238R, GLU245R, GLU24S, GLU27S, GLU37S, GLU38S, GLU52S, GLU55S, GLU61S, GLU62S, GLU73S, GLU75S, GLY227R, GLY43S, GLY54S, GLY63S, HIS199R, HIS213R, HIS239R, HIS66S, ILE195R, ILE202R, ILE203R, ILE209R, ILE230R, ILE233R, ILE44S, ILE67S, LEU11S, LEU192R, LEU205R, LEU212R, LEU21S, LEU222R, LEU26S, LEU33S, LEU35S, LEU47S, LEU50S, LEU57S, LEU78S, LYS204R, LYS40S, LYS72S, LYS76S, LYS79S, MET14S, MET215R, MET217R, MET219R, MET221R, MET229R, MET32S, MET49S, MET64S, MET71S, PHE216R, SER193R, SER200R, SER208R, SER225R, SER249R, SER25S, SER28S, SER39S, THR197R, THR251R, THR29S, THR46S, TYR235R, TYR243R, VAL223R, VAL237R, VAL241R, VAL244R, VAL248R, VAL36S, VAL60S
• R-T: ALA164T, ALA185T, ALA220R, ALA240R, ARG142T, ARG161T, ARG198R, ASN159T, ASN175T, ASN188T, ASP147T, GLN174T, GLN226R, GLU143T, GLU234R, GLY139T, GLY168T, HIS162T, HIS199R, HIS213R, ILE157T, ILE171T, ILE178T, ILE181T, ILE192T, ILE195R, ILE202R, ILE209R, ILE230R, ILE233R, LEU150T, LEU160T, LEU165T, LEU205R, LEU212R, LEU222R, MET146T, MET163T, MET167T, MET215R, MET219R, PHE216R, SER154T, SER208R, VAL153T, VAL223R, VAL237R, VAL241R, VAL244R
• R-k: ALA53k, ARG210R, ARG232R, ARG48k, ARG59k, ARG63k, ARG67k, ASP214R, ASP218R, GLN226R, GLU211R, GLU56k, GLU60k, GLY65k, HIS213R, ILE230R, ILE233R, ILE66k, LEU212R, LEU222R, LYS49k, LYS69k, MET215R, MET217R, MET219R, MET221R, MET229R, PHE216R, SER225R, TYR235R, TYR52k, TYR70k, VAL62k
• S-T: ALA141T, ALA164T, ALA185T, ALA18S, ALA195T, ALA199T, ALA22S, ALA42S, ALA74S, ARG142T, ARG16S, ARG176T, ARG17S, ARG180T, ARG191T, ARG198T, ARG30S, ARG31S, ARG45S, ARG59S, ASN144T, ASN149T, ASN159T, ASN169T, ASN175T, ASN188T, ASN196T, ASN65S, ASN68S, ASP147T, ASP166T, ASP172T, ASP186T, ASP193T, ASP19S, ASP23S, ASP41S, ASP51S, ASP58S, ASP70S, GLN152T, GLN15S, GLN174T, GLN177T, GLN197T, GLN20S, GLN34S, GLN53S, GLN56S, GLN69S, GLU143T, GLU145T, GLU148T, GLU151T, GLU170T, GLU183T, GLU194T, GLU24S, GLU27S, GLU37S, GLU38S, GLU52S, GLU55S, GLU61S, GLU62S, GLU73S, GLU75S, GLY139T, GLY155T, GLY158T, GLY168T, GLY43S, GLY54S, GLY63S, HIS162T, HIS66S, ILE156T, ILE157T, ILE171T, ILE178T, ILE181T, ILE192T, ILE44S, ILE67S, LEU150T, LEU160T, LEU165T, LEU21S, LEU26S, LEU33S, LEU35S, LEU47S, LEU50S, LEU57S, LYS184T, LYS189T, LYS40S, LYS72S, LYS79S, MET146T, MET163T, MET167T, MET182T, MET32S, MET49S, MET64S, MET71S, SER154T, SER187T, SER25S, SER28S, SER39S, THR173T, THR190T, THR200T, THR29S, THR46S, VAL153T, VAL36S, VAL60S
• S-W: ARG16W, ARG17W, ARG45S, ARG8W, ASN9W, ASP19W, ASP23W, ASP41S, ASP51S, GLN15W, GLN20W, GLU12W, GLU13W, GLU52S, GLU55S, ILE44S, LEU11W, LEU47S, LEU50S, LYS40S, MET49S, VAL48S
• S-X: ARG142X, ILE44S, LEU47S, LYS40S
• S-Y: ARG30Y, ASN65S, ASN68S, GLN34Y, GLN69S, GLU61S, LYS72S
• S-e: ASP51e, GLU37S, GLU52e, GLU55e, LEU33S, VAL48e
• T-W: ALA22W, ARG161T, ARG30W, ASN159T, ASP166T, ASP19W, ASP23W, GLN20W, GLU24W, GLU27W, GLY155T, GLY158T, HIS162T, ILE156T, ILE157T, LEU160T, LEU26W, MET163T, SER154T, SER25W
• T-X: ALA141X, ALA164T, ARG142X, ARG161T, ASN144X, ASN159T, ASN169T, ASP166T, GLU143X, GLU145X, GLU170T, GLY139X, GLY158T, GLY168T, HIS162T, LEU160T, LEU165T, MET146X, MET163T, MET167T, SER140X
• T-Y: ARG176T, ARG180T, ARG191T, ARG30Y, GLN34Y, GLN38Y, GLU41Y, ILE45Y, LYS184T, VAL42Y
• T-a: ARG161T, ASP51a
• T-b: ARG161b, ARG176T, ASN159b, ASN169T, ASP166T, ASP166b, ASP172T, GLU170T, GLY158b, GLY168T, HIS162b, LEU165T, LEU165b, MET163b, THR173T
• T-e: ALA42e, ARG45e, ASN144T, ASN149T, ASP147T, ASP41e, ASP51e, GLN152T, GLN53e, GLU143T, GLU145T, GLU148T, GLU151T, GLU52e, GLU55e, GLY155T, GLY43e, ILE156T, ILE44e, LEU150T, LEU47e, LYS40e, MET146T, MET49e, SER140T, SER154T, THR46e, VAL153T, VAL48e
• T-f: ASN144T, ASN159f, ASP166f, GLU148T, HIS162f, MET163f, SER140T
• U-V: ALA220V, ALA37U, ARG198V, ARG210V, ARG30U, ARG31U, ARG47U, ARG56U, ASN207V, ASN29U, ASN49U, ASP214V, ASP218V, ASP231V, ASP40U, ASP44U, ASP51U, ASP57U, GLN226V, GLN33U, GLN34U, GLN36U, GLN38U, GLN58U, GLU194V, GLU201V, GLU206V, GLU211V, GLU224V, GLU228V, GLU41U, GLU55U, GLY227V, GLY27U, HIS199V, HIS213V, ILE195V, ILE202V, ILE203V, ILE209V, ILE230V, ILE233V, ILE45U, LEU205V, LEU212V, LEU222V, LEU26U, LEU32U, LEU54U, LEU60U, LYS204V, LYS52U, LYS59U, MET215V, MET217V, MET219V, MET229V, MET46U, PHE216V, SER200V, SER208V, SER225V, SER28U, THR197V, THR35U, VAL223V, VAL39U, VAL42U, VAL43U, VAL48U, VAL50U, VAL53U
• U-W: ALA42W, ARG56U, ASN49U, GLN53W, GLN56W, GLY43W, GLY54W, LEU32U, LEU47W, LEU50W, LEU57W, LEU60U, MET32W, MET46U, MET49W, SER39W, THR29W, THR35U, THR46W, VAL36W, VAL39U, VAL42U, VAL53U
• U-X: ALA164X, ALA37U, ARG161X, ARG176X, ARG180X, ARG31U, ARG47U, ARG56U, ASN144X, ASN159X, ASN169X, ASN175X, ASN29U, ASN49U, ASP147X, ASP166X, ASP172X, ASP179X, ASP40U, ASP44U, ASP51U, ASP57U, GLN174X, GLN177X, GLN34U, GLN36U, GLN38U, GLN58U, GLU143X, GLU148X, GLU151X, GLU170X, GLU41U, GLU55U, GLY155X, GLY158X, GLY168X, GLY27U, HIS162X, ILE156X, ILE157X, ILE171X, ILE178X, ILE181X, ILE45U, LEU150X, LEU160X, LEU165X, LEU26U, LEU32U, LEU54U, LEU60U, LYS52U, LYS59U, MET146X, MET163X, MET167X, MET182X, MET46U, SER154X, SER28U, THR173X, THR35U, VAL153X, VAL39U, VAL42U, VAL43U, VAL48U, VAL50U, VAL53U
• U-a: ALA42a, ARG30U, ARG31U, ARG45a, ASP41a, GLN34U, GLN34a, GLU37a, GLU38a, GLY27U, GLY43a, ILE44a, LEU26U, LEU33a, LYS40a, SER28U, SER39a, VAL36a
• U-b: ARG30U, ARG31U, ASN149b, ASN159b, GLN152b, GLY155b, GLY27U, ILE156b, LEU160b, LEU26U, MET163b, SER28U
• U-l: ARG47U, ARG59l, ARG63l, ARG67l, ASP51U, ASP57U, ASP68l, GLN58U, GLN64l, GLU55U, GLU56l, GLU60l, ILE66l, LEU54U, LEU60U, LYS59U, LYS69l, MET46U, TYR52l, TYR70l, VAL43U, VAL50U, VAL53U, VAL62l
• V-W: ALA18W, ALA191V, ALA220V, ALA22W, ALA240V, ALA247V, ALA42W, ALA74W, ARG17W, ARG198V, ARG210V, ARG232V, ARG246V, ARG30W, ARG31W, ARG45W, ARG59W, ASN207V, ASN236V, ASN65W, ASN68W, ASN77W, ASP19W, ASP214V, ASP218V, ASP231V, ASP23W, ASP242V, ASP41W, ASP51W, ASP58W, ASP70W, GLN15W, GLN20W, GLN226V, GLN34W, GLN53W, GLN56W, GLN69W, GLU13W, GLU196V, GLU201V, GLU206V, GLU211V, GLU224V, GLU228V, GLU234V, GLU238V, GLU245V, GLU24W, GLU27W, GLU37W, GLU38W, GLU52W, GLU55W, GLU61W, GLU62W, GLU73W, GLU75W, GLY227V, GLY43W, GLY54W, GLY63W, HIS199V, HIS213V, HIS239V, HIS66W, ILE195V, ILE202V, ILE203V, ILE209V, ILE230V, ILE233V, ILE44W, ILE67W, LEU192V, LEU205V, LEU212V, LEU21W, LEU222V, LEU26W, LEU33W, LEU35W, LEU47W, LEU50W, LEU57W, LYS204V, LYS40W, LYS72W, LYS76W, MET14W, MET215V, MET217V, MET219V, MET221V, MET229V, MET32W, MET49W, MET64W, MET71W, PHE216V, SER193V, SER200V, SER208V, SER225V, SER25W, SER28W, SER39W, THR197V, THR29W, THR46W, TYR235V, TYR243V, VAL223V, VAL237V, VAL241V, VAL244V, VAL248V, VAL36W, VAL60W
• V-X: ALA164X, ALA185X, ALA191V, ALA220V, ALA240V, ARG142X, ARG161X, ARG198V, ASN149X, ASN159X, ASN175X, ASN188X, ASN236V, ASP147X, GLN174X, GLN226V, GLU143X, GLU234V, GLY139X, GLY168X, HIS162X, HIS199V, HIS213V, ILE157X, ILE171X, ILE178X, ILE181X, ILE192X, ILE195V, ILE202V, ILE209V, ILE230V, ILE233V, LEU150X, LEU160X, LEU165X, LEU205V, LEU212V, LEU222V, LYS189X, MET146X, MET163X, MET167X, MET215V, MET219V, PHE216V, SER154X, SER208V, VAL153X, VAL223V, VAL237V, VAL241V, VAL244V
• V-a: ARG198V, LYS40a
• V-d: ALA220V, ARG210V, ARG210d, ARG232V, ARG232d, ASN207V, ASN207d, ASP214V, ASP214d, ASP218V, ASP218d, ASP231V, GLN226V, GLU196V, GLU196d, GLU206V, GLU206d, GLU211d, GLU224V, GLU228V, GLU228d, GLU234V, GLY227V, HIS199V, HIS199d, HIS213V, HIS213d, HIS239V, ILE195d, ILE202d, ILE203V, ILE203d, ILE230V, ILE233V, LEU192V, LEU192d, LEU222V, LEU222d, LYS204d, MET215d, MET217V, MET217d, MET219d, MET221V, MET221d, MET229V, SER190d, SER193d, SER200d, SER208d, SER225V, SER225d, THR197d, TYR235V
• V-e: ALA18e, ALA220V, ARG17e, ARG232V, ARG246V, ARG31e, ARG8e, ASN236V, ASN9e, ASP231V, ASP242V, GLN20e, GLU10e, GLU13e, GLU224V, GLU228V, GLU234V, GLU238V, GLU245V, GLU24e, GLU27e, GLY227V, HIS213V, HIS239V, ILE230V, ILE233V, LEU21e, LEU35e, MET14e, MET217V, MET221V, SER25e, SER28e, TYR235V, VAL241V
• V-l: ARG210V, ARG232V, ARG48l, ARG59l, ARG63l, ARG67l, ASP214V, ASP218V, GLN226V, GLU211V, GLU56l, GLU58l, GLU60l, HIS213V, ILE233V, ILE66l, LEU212V, LEU222V, LYS51l, LYS69l, MET215V, MET217V, MET219V, MET221V, MET229V, PHE216V, SER225V, TYR52l, TYR70l, VAL62l
• V-n: ALA61n, ARG198V, ARG210V, ARG48n, ARG59n, ARG63n, ASN207V, ASP214V, GLU194V, GLU196V, GLU201V, GLU211V, GLU47n, GLU58n, GLY65n, ILE195V, ILE203V, ILE66n, LEU192V, LYS204V, LYS51n, LYS54n, LYS69n, SER193V, SER200V, THR197V, TYR52n, TYR70n, VAL62n
• W-X: ALA141X, ALA164X, ALA185X, ALA18W, ALA195X, ALA199X, ALA22W, ALA42W, ALA74W, ARG142X, ARG16W, ARG176X, ARG17W, ARG180X, ARG191X, ARG198X, ARG30W, ARG31W, ARG45W, ARG59W, ASN144X, ASN149X, ASN159X, ASN169X, ASN175X, ASN188X, ASN196X, ASN65W, ASN68W, ASP147X, ASP166X, ASP186X, ASP193X, ASP19W, ASP23W, ASP41W, ASP51W, ASP58W, ASP70W, GLN152X, GLN15W, GLN174X, GLN177X, GLN20W, GLN34W, GLN53W, GLN56W, GLN69W, GLU143X, GLU145X, GLU148X, GLU151X, GLU170X, GLU183X, GLU194X, GLU24W, GLU27W, GLU37W, GLU38W, GLU52W, GLU55W, GLU61W, GLU62W, GLU73W, GLU75W, GLY139X, GLY155X, GLY158X, GLY168X, GLY43W, GLY54W, GLY63W, HIS162X, HIS66W, ILE156X, ILE157X, ILE171X, ILE178X, ILE181X, ILE192X, ILE44W, ILE67W, LEU150X, LEU160X, LEU165X, LEU21W, LEU26W, LEU33W, LEU35W, LEU47W, LEU50W, LEU57W, LYS184X, LYS189X, LYS40W, LYS72W, LYS76W, MET146X, MET163X, MET167X, MET182X, MET32W, MET49W, MET64W, MET71W, SER154X, SER187X, SER25W, SER28W, SER39W, THR173X, THR190X, THR29W, THR46W, VAL153X, VAL36W, VAL60W
• W-a: GLU37W, GLU52a, LEU33W, VAL48a
• W-d: ALA220d, ALA42W, ARG16W, ARG17W, ARG210d, ARG232d, ARG246d, ARG31W, ARG45W, ARG8W, ASN236d, ASN9W, ASP214d, ASP218d, ASP231d, ASP23W, ASP242d, ASP41W, GLN20W, GLN226d, GLN34W, GLN56W, GLU10W, GLU12W, GLU13W, GLU206d, GLU224d, GLU228d, GLU234d, GLU238d, GLU24W, GLU27W, GLU38W, GLY227d, HIS199d, HIS213d, HIS239d, ILE203d, ILE230d, ILE233d, LEU11W, LEU192d, LEU21W, LEU222d, LEU35W, MET14W, MET217d, MET221d, MET229d, MET49W, SER225d, SER28W, TYR235d, TYR243d
• W-e: ALA42W, ARG16W, ARG16e, ARG17e, ARG31W, ARG31e, ARG45W, ARG45e, ARG59W, ARG8e, ASN9e, ASP23e, ASP41W, GLN20e, GLN34W, GLN34e, GLN53W, GLN56W, GLN56e, GLU12e, GLU13e, GLU24e, GLU27W, GLU27e, GLU38W, GLU38e, GLU52W, GLU55W, GLU62W, ILE44W, LEU11e, LEU21e, LEU35W, LEU35e, LEU57W, MET14e, MET49W, MET49e, SER28e, THR46W, VAL48W, VAL60W
• W-n: ARG17W, ARG48n, MET14W
• X-a: ALA42a, ARG45a, ASN144X, ASN149X, ASP147X, ASP41a, ASP51a, GLN152X, GLU143X, GLU145X, GLU148X, GLU151X, GLU52a, GLY155X, GLY43a, ILE156X, ILE44a, LEU150X, LEU47a, LYS40a, MET146X, MET49a, SER140X, THR46a, VAL153X, VAL48a
• X-b: ALA141X, ALA164b, ASN144X, ASN159b, ASP147X, ASP166b, GLU143X, GLU148X, GLY158b, HIS162b, MET163b, MET167b, SER140X
• Y-Z: ALA191Z, ALA220Z, ALA37Y, ARG198Z, ARG210Z, ARG30Y, ARG31Y, ARG47Y, ARG56Y, ASN207Z, ASN29Y, ASN49Y, ASP214Z, ASP218Z, ASP231Z, ASP40Y, ASP44Y, ASP51Y, ASP57Y, GLN226Z, GLN33Y, GLN34Y, GLN36Y, GLN38Y, GLN58Y, GLU194Z, GLU201Z, GLU206Z, GLU211Z, GLU224Z, GLU228Z, GLU41Y, GLU55Y, GLY227Z, GLY27Y, HIS199Z, HIS213Z, ILE195Z, ILE202Z, ILE203Z, ILE209Z, ILE230Z, ILE233Z, ILE45Y, LEU205Z, LEU212Z, LEU222Z, LEU26Y, LEU32Y, LEU54Y, LEU60Y, LYS204Z, LYS52Y, LYS59Y, MET215Z, MET217Z, MET219Z, MET229Z, MET46Y, PHE216Z, SER200Z, SER208Z, SER225Z, SER28Y, THR197Z, THR35Y, VAL223Z, VAL39Y, VAL42Y, VAL43Y, VAL48Y, VAL50Y, VAL53Y
• Y-a: ALA42a, ARG56Y, ASN49Y, ASP51a, GLN36Y, GLN53a, GLN56a, GLU52a, GLY43a, GLY54a, LEU32Y, LEU47a, LEU50a, LEU57a, LEU60Y, MET32a, MET46Y, MET49a, SER25a, SER39a, THR29a, THR35Y, THR46a, VAL36a, VAL39Y, VAL42Y, VAL53Y, VAL60a
• Y-b: ALA164b, ALA37Y, ARG161b, ARG176b, ARG180b, ARG31Y, ARG47Y, ARG56Y, ASN144b, ASN159b, ASN169b, ASN175b, ASN29Y, ASN49Y, ASP147b, ASP166b, ASP172b, ASP179b, ASP40Y, ASP44Y, ASP51Y, ASP57Y, GLN174b, GLN177b, GLN33Y, GLN34Y, GLN36Y, GLN38Y, GLN58Y, GLU143b, GLU148b, GLU151b, GLU170b, GLU41Y, GLU55Y, GLY155b, GLY158b, GLY168b, GLY27Y, HIS162b, ILE156b, ILE157b, ILE171b, ILE178b, ILE181b, ILE45Y, LEU150b, LEU160b, LEU165b, LEU26Y, LEU32Y, LEU54Y, LEU60Y, LYS52Y, LYS59Y, MET146b, MET163b, MET167b, MET182b, MET46Y, SER154b, SER28Y, THR173b, THR35Y, VAL153b, VAL39Y, VAL42Y, VAL43Y, VAL48Y, VAL50Y, VAL53Y
• Y-m: ARG47Y, ARG56Y, ARG59m, ARG63m, ARG67m, ASP51Y, ASP57Y, ASP68m, GLN58Y, GLN64m, GLU55Y, GLU60m, ILE66m, LEU54Y, LEU60Y, LYS59Y, LYS69m, MET46Y, TYR70m, VAL43Y, VAL50Y, VAL53Y, VAL62m
• Z-a: ALA18a, ALA191Z, ALA220Z, ALA22a, ALA240Z, ALA247Z, ALA42a, ALA74a, ARG16a, ARG17a, ARG198Z, ARG210Z, ARG232Z, ARG246Z, ARG30a, ARG31a, ARG45a, ARG59a, ASN207Z, ASN236Z, ASN65a, ASN68a, ASP19a, ASP214Z, ASP218Z, ASP231Z, ASP23a, ASP242Z, ASP41a, ASP51a, ASP58a, ASP70a, GLN15a, GLN20a, GLN226Z, GLN34a, GLN53a, GLN56a, GLN69a, GLU13a, GLU196Z, GLU201Z, GLU206Z, GLU211Z, GLU224Z, GLU228Z, GLU234Z, GLU238Z, GLU245Z, GLU24a, GLU27a, GLU37a, GLU38a, GLU52a, GLU55a, GLU61a, GLU62a, GLU73a, GLY227Z, GLY43a, GLY54a, GLY63a, HIS199Z, HIS213Z, HIS239Z, HIS66a, ILE195Z, ILE202Z, ILE203Z, ILE209Z, ILE230Z, ILE233Z, ILE44a, ILE67a, LEU11a, LEU192Z, LEU205Z, LEU212Z, LEU21a, LEU222Z, LEU26a, LEU33a, LEU35a, LEU47a, LEU50a, LEU57a, LYS204Z, LYS40a, MET14a, MET215Z, MET217Z, MET219Z, MET221Z, MET229Z, MET32a, MET49a, MET64a, MET71a, PHE216Z, SER190Z, SER193Z, SER200Z, SER208Z, SER225Z, SER25a, SER28a, SER39a, THR197Z, THR29a, THR46a, TYR235Z, TYR243Z, VAL223Z, VAL237Z, VAL241Z, VAL244Z, VAL36a, VAL48a, VAL60a
• Z-b: ALA164b, ALA185b, ALA220Z, ALA240Z, ARG142b, ARG161b, ARG198Z, ASN159b, ASN188b, ASP147b, GLN174b, GLN226Z, GLU143b, GLY139b, HIS162b, HIS199Z, HIS213Z, ILE157b, ILE171b, ILE178b, ILE181b, ILE192b, ILE195Z, ILE202Z, ILE209Z, ILE230Z, ILE233Z, LEU150b, LEU160b, LEU165b, LEU205Z, LEU212Z, LEU222Z, MET146b, MET163b, MET167b, MET215Z, MET219Z, PHE216Z, SER154b, SER208Z, VAL153b, VAL223Z, VAL237Z, VAL244Z
• Z-m: ARG210Z, ARG232Z, ARG48m, ARG59m, ARG63m, ARG67m, ASP214Z, ASP218Z, GLN226Z, GLU211Z, GLU228Z, GLU56m, HIS213Z, ILE66m, LEU212Z, LEU222Z, LYS69m, MET215Z, MET217Z, MET219Z, MET221Z, MET229Z, PHE216Z, SER225Z, TYR52m, TYR70m, VAL62m
• a-b: ALA141b, ALA164b, ALA185b, ALA18a, ALA195b, ALA199b, ALA22a, ALA42a, ALA74a, ARG142b, ARG16a, ARG176b, ARG17a, ARG180b, ARG191b, ARG198b, ARG30a, ARG31a, ARG45a, ARG59a, ASN144b, ASN149b, ASN159b, ASN169b, ASN175b, ASN188b, ASN196b, ASN65a, ASN68a, ASP147b, ASP166b, ASP172b, ASP186b, ASP193b, ASP19a, ASP23a, ASP41a, ASP51a, ASP58a, ASP70a, GLN152b, GLN15a, GLN174b, GLN177b, GLN197b, GLN20a, GLN34a, GLN53a, GLN56a, GLN69a, GLU143b, GLU145b, GLU148b, GLU151b, GLU170b, GLU183b, GLU194b, GLU24a, GLU27a, GLU37a, GLU38a, GLU52a, GLU55a, GLU61a, GLU62a, GLU75a, GLY139b, GLY155b, GLY158b, GLY168b, GLY43a, GLY54a, GLY63a, HIS162b, HIS66a, ILE156b, ILE157b, ILE171b, ILE178b, ILE181b, ILE192b, ILE44a, ILE67a, LEU150b, LEU160b, LEU165b, LEU21a, LEU26a, LEU33a, LEU35a, LEU47a, LEU50a, LEU57a, LEU78a, LYS184b, LYS189b, LYS40a, LYS72a, LYS76a, LYS79a, MET146b, MET163b, MET167b, MET182b, MET32a, MET49a, MET64a, MET71a, SER154b, SER187b, SER25a, SER28a, SER39a, THR173b, THR190b, THR29a, THR46a, VAL153b, VAL36a, VAL48a, VAL60a
• c-d: ALA220d, ALA37c, ARG198d, ARG210d, ARG30c, ARG31c, ARG47c, ARG56c, ASN207d, ASN29c, ASN49c, ASP214d, ASP218d, ASP231d, ASP40c, ASP44c, ASP51c, ASP57c, GLN226d, GLN33c, GLN34c, GLN36c, GLN38c, GLN58c, GLU194d, GLU201d, GLU206d, GLU211d, GLU224d, GLU41c, GLU55c, GLY227d, GLY27c, HIS199d, HIS213d, ILE202d, ILE203d, ILE209d, ILE230d, ILE233d, ILE45c, LEU205d, LEU212d, LEU222d, LEU32c, LEU54c, LEU60c, LYS204d, LYS52c, LYS59c, MET215d, MET217d, MET219d, MET229d, MET46c, PHE216d, SER200d, SER208d, SER225d, SER28c, THR197d, THR35c, VAL223d, VAL39c, VAL42c, VAL43c, VAL48c, VAL50c, VAL53c
• c-e: ALA42e, ARG56c, ASN49c, GLN36c, GLN53e, GLN56e, GLY43e, GLY54e, LEU32c, LEU47e, LEU50e, LEU57e, LEU60c, MET32e, MET46c, MET49e, SER25e, SER39e, THR29e, THR35c, THR46e, VAL36e, VAL39c, VAL42c, VAL53c
• c-f: ALA164f, ALA37c, ARG161f, ARG176f, ARG180f, ARG31c, ARG47c, ARG56c, ASN159f, ASN169f, ASN175f, ASN29c, ASN49c, ASP147f, ASP166f, ASP172f, ASP179f, ASP40c, ASP44c, ASP51c, ASP57c, GLN174f, GLN177f, GLN33c, GLN34c, GLN36c, GLN38c, GLU143f, GLU148f, GLU151f, GLU170f, GLU41c, GLU55c, GLY155f, GLY158f, GLY168f, GLY27c, HIS162f, ILE156f, ILE157f, ILE171f, ILE178f, ILE181f, ILE45c, LEU150f, LEU160f, LEU165f, LEU32c, LEU54c, LEU60c, LYS52c, LYS59c, MET146f, MET163f, MET167f, MET182f, MET46c, SER154f, SER28c, THR173f, THR35c, VAL153f, VAL39c, VAL42c, VAL43c, VAL48c, VAL50c, VAL53c
• c-l: ASN29c, LYS51l
• c-n: ARG47c, ARG56c, ARG59n, ARG63n, ARG67n, ASP51c, ASP57c, ASP68n, GLN58c, GLN64n, GLU55c, GLU56n, GLU60n, GLY65n, ILE66n, LEU54c, LEU60c, LYS59c, LYS69n, TYR52n, TYR70n, VAL43c, VAL50c, VAL53c, VAL62n
• d-e: ALA18e, ALA191d, ALA220d, ALA22e, ALA240d, ALA247d, ALA42e, ALA74e, ARG17e, ARG198d, ARG210d, ARG232d, ARG246d, ARG30e, ARG31e, ARG45e, ARG59e, ASN207d, ASN236d, ASN65e, ASN68e, ASN77e, ASP19e, ASP214d, ASP218d, ASP231d, ASP23e, ASP242d, ASP41e, ASP51e, ASP58e, ASP70e, GLN15e, GLN20e, GLN226d, GLN34e, GLN53e, GLN56e, GLN69e, GLU10e, GLU13e, GLU196d, GLU201d, GLU206d, GLU211d, GLU224d, GLU228d, GLU234d, GLU238d, GLU245d, GLU24e, GLU27e, GLU37e, GLU38e, GLU52e, GLU55e, GLU61e, GLU62e, GLU73e, GLU75e, GLY227d, GLY43e, GLY54e, GLY63e, HIS199d, HIS213d, HIS239d, HIS66e, ILE195d, ILE202d, ILE203d, ILE209d, ILE230d, ILE233d, ILE44e, ILE67e, LEU192d, LEU205d, LEU212d, LEU21e, LEU222d, LEU26e, LEU33e, LEU35e, LEU47e, LEU50e, LEU57e, LEU78e, LYS204d, LYS40e, MET14e, MET215d, MET217d, MET219d, MET221d, MET229d, MET32e, MET49e, MET64e, MET71e, PHE216d, SER190d, SER193d, SER200d, SER208d, SER225d, SER25e, SER28e, SER39e, THR197d, THR29e, THR46e, TYR235d, TYR243d, VAL223d, VAL237d, VAL241d, VAL244d, VAL248d, VAL36e, VAL48e, VAL60e
• d-f: ALA164f, ALA185f, ALA220d, ALA240d, ALA247d, ARG161f, ARG198d, ASN159f, ASN175f, ASN188f, ASN196f, ASP147f, GLN174f, GLN226d, GLU143f, GLY139f, GLY168f, HIS162f, HIS199d, HIS213d, ILE157f, ILE171f, ILE178f, ILE181f, ILE192f, ILE195d, ILE202d, ILE209d, ILE230d, ILE233d, LEU150f, LEU160f, LEU165f, LEU205d, LEU212d, LEU222d, MET146f, MET163f, MET167f, MET215d, MET219d, PHE216d, SER154f, SER208d, VAL153f, VAL223d, VAL237d, VAL241d, VAL244d
• d-l: ARG48l, ASN207d, ASP214d, GLU201d, GLU211d, GLU58l, ILE203d, ILE66l, LYS204d, LYS51l, LYS54l, LYS69l, SER190d, SER193d, SER200d, THR197d, VAL62l
• d-n: ARG210d, ARG232d, ARG48n, ARG59n, ARG63n, ASP214d, ASP218d, GLN226d, GLU211d, GLU228d, GLU56n, GLY227d, HIS213d, ILE66n, LEU212d, LEU222d, LYS69n, MET215d, MET217d, MET219d, MET221d, MET229d, PHE216d, SER225d, TYR52n, TYR70n, VAL223d, VAL62n
• e-f: ALA141f, ALA164f, ALA185f, ALA18e, ALA195f, ALA199f, ALA22e, ALA42e, ALA74e, ARG142f, ARG16e, ARG176f, ARG180f, ARG191f, ARG198f, ARG30e, ARG31e, ARG45e, ARG59e, ASN144f, ASN149f, ASN159f, ASN169f, ASN175f, ASN188f, ASN196f, ASN65e, ASN68e, ASP147f, ASP166f, ASP172f, ASP186f, ASP193f, ASP19e, ASP23e, ASP41e, ASP51e, ASP58e, ASP70e, GLN152f, GLN174f, GLN177f, GLN197f, GLN20e, GLN34e, GLN53e, GLN56e, GLN69e, GLU143f, GLU145f, GLU148f, GLU151f, GLU170f, GLU183f, GLU194f, GLU24e, GLU27e, GLU37e, GLU38e, GLU52e, GLU55e, GLU61e, GLU62e, GLU75e, GLY139f, GLY155f, GLY158f, GLY168f, GLY43e, GLY54e, GLY63e, HIS162f, HIS66e, ILE156f, ILE157f, ILE171f, ILE178f, ILE181f, ILE192f, ILE44e, ILE67e, LEU150f, LEU160f, LEU165f, LEU21e, LEU26e, LEU33e, LEU35e, LEU47e, LEU50e, LEU57e, LEU78e, LYS184f, LYS189f, LYS40e, LYS72e, LYS79e, MET146f, MET163f, MET167f, MET182f, MET32e, MET49e, MET64e, MET71e, SER154f, SER187f, SER25e, SER28e, SER39e, THR173f, THR190f, THR29e, THR46e, VAL153f, VAL36e, VAL48e, VAL60e
• h-j: ASP68h, ASP68j, GLY65h, GLY65j, LYS69h, LYS69j, TYR70h, TYR70j
• i-n: ARG63i, GLU56i, GLU60i, LYS26n, LYS32n, PRO28n, TYR52i
• l-n: ASP68l, ASP68n, LYS69l, LYS69n, TYR70l, TYR70n