3RKO

crystal structure of the membrane domain of respiratory complex i from e. coli at 3.0 angstrom resolution

• Total interactions analyzed: 66
• Total true interactions: 34
• Strongest Interaction:
  • Chains: B-G
  • Int. Res.: 46
  • Norm. En. per Res.: -3.5073
• Hub Node: L(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
L-M	-21.3483	-12.2068	-547.195	-580.7501	238	51	21	24554	1	18	19
L-N	-4.6776	-5.5891	-298.918	-309.1848	120	25	23	14746	0	7	6
L-K	-30.0664	-22.065	-107.36	-159.4914	46	5	5	4713	2	3	5
L-J	0.0	0.0	-48.4159	-48.4159	37	10	7	3078	0	0	1
L-E	0.0	0.0	-0.0072	-0.0072	3	0	0	6	0	3	0
L-F	0.0	-2.3413	-0.0437	-2.385	6	0	0	23	0	1	4
M-N	-9.2849	-7.9745	-300.301	-317.5604	151	29	24	16650	1	4	9
M-D	0.0	0.0	-43.8963	-43.8963	48	0	0	2147	0	7	1
M-G	0.0	0.0	-55.3773	-55.3773	31	4	0	2579	0	1	6
M-E	0.0	0.0	-0.0011	-0.0011	2	0	0	3	0	0	0
M-F	0.0	0.0	-18.5648	-18.5648	29	6	3	1649	0	0	0
N-K	-39.4958	10.3542	-436.585	-465.7265	163	35	26	19536	0	17	24
N-A	-13.9386	2.2798	-66.9844	-78.6432	57	5	7	3447	0	4	3
N-J	0.0	-21.1893	-275.994	-297.1832	146	31	26	14887	1	12	15
N-B	0.0	0.0	-0.0011	-0.0011	4	0	0	3	0	0	0
N-C	-11.037	-2.0269	-80.9513	-94.0152	53	10	0	4302	0	11	8
N-D	0.0	0.0	-0.3299	-0.3299	4	0	0	31	0	1	0
K-A	-2.5066	14.1046	-65.2636	-53.6655	46	8	5	3014	0	0	6
K-J	-37.8413	-37.9281	-753.009	-828.7784	245	82	59	37243	0	18	15
K-C	0.0	0.0	-0.0396	-0.0396	3	0	0	24	0	0	1
A-J	0.0	-23.2927	-494.921	-518.2137	170	30	32	23676	2	11	17
A-B	0.0	17.2346	-8.7723	8.4623	7	0	0	319	0	6	6
J-C	0.0	0.0	-0.0072	-0.0072	2	0	0	10	0	0	0
B-C	-10.8876	-12.2665	-554.986	-578.1401	240	38	21	24588	1	18	19
B-D	-8.6348	-5.9173	-299.586	-314.1381	121	22	23	14795	0	7	6
B-G	-30.3618	-22.34	-108.633	-161.3348	46	9	5	4764	2	3	5
B-F	0.0	0.0	-41.7683	-41.7683	37	11	7	3071	0	0	1
C-D	-9.3168	-8.0589	-295.287	-312.6627	150	32	24	16679	1	4	9
D-G	-43.5473	10.4837	-430.075	-463.1386	164	42	26	19586	0	17	24
D-E	-26.0333	2.2914	-68.233	-91.9749	57	6	7	3525	0	4	3
D-F	0.0	-20.7213	-277.786	-298.5073	145	34	26	14943	1	12	15
G-E	0.0	14.4564	-62.9129	-48.4565	46	9	5	3006	0	0	6
G-F	-35.0223	-38.2138	-753.356	-826.5921	245	76	59	37259	0	18	15
E-F	0.0	-23.2036	-492.106	-515.3096	171	31	32	23670	2	11	17

Interface residues

• L-M: ALA165L, ALA166L, ALA167L, ALA170L, ALA182L, ALA184L, ALA19L, ALA302M, ALA305M, ALA307M, ALA337M, ALA386M, ALA394M, ALA432M, ALA438M, ALA448M, ALA557L, ALA573L, ARG115L, ARG175L, ARG22L, ARG24L, ARG313M, ARG372M, ARG442M, ARG562L, ARG577L, ASN163L, ASN190L, ASN566L, ASN570L, ASN74L, ASP160L, ASP163M, ASP178L, ASP246M, ASP487M, ASP563L, ASP72L, CYS149L, GLN308M, GLN335M, GLN339M, GLN416M, GLN483M, GLU111L, GLU144L, GLU191L, GLU407M, GLY112L, GLY142L, GLY145L, GLY147L, GLY155L, GLY164L, GLY177L, GLY193L, GLY242M, GLY297M, GLY301M, GLY340M, GLY375M, GLY376M, GLY397M, GLY400M, GLY402M, GLY406M, GLY413M, GLY428M, GLY446M, GLY479M, GLY555L, GLY71L, GLY76L, HIS241M, HIS441M, HIS490M, ILE176M, ILE187L, ILE296M, ILE343M, ILE410M, ILE421M, ILE424M, ILE493M, ILE556L, ILE75L, ILE8L, LEU122L, LEU12L, LEU136L, LEU137L, LEU138L, LEU141L, LEU148L, LEU152L, LEU181L, LEU185L, LEU188L, LEU192L, LEU195L, LEU240M, LEU244M, LEU336M, LEU377M, LEU387M, LEU389M, LEU396M, LEU411M, LEU429M, LEU437M, LEU440M, LEU465M, LEU469M, LEU477M, LEU478M, LEU486M, LEU554L, LEU559L, LEU560L, LEU565L, LEU64L, LYS162L, LYS165M, LYS169L, LYS173M, LYS229L, LYS380M, LYS382M, LYS447M, LYS561L, MET139L, MET168L, MET214L, MET221L, MET304M, MET381M, MET398M, MET409M, MET568L, MET569L, MET68L, PHE156L, PHE15L, PHE171L, PHE180L, PHE183L, PHE186L, PHE20L, PHE299M, PHE306M, PHE325M, PHE390M, PHE404M, PHE408M, PHE412M, PHE415M, PHE427M, PHE431M, PHE445M, PHE480M, PHE549L, PHE553L, PHE73L, PHE77L, PRO161L, PRO239M, PRO245M, PRO385M, PRO399M, PRO419M, PRO482M, PRO484M, PRO552L, PRO564L, PRO572L, SER126L, SER334M, SER379M, SER414M, SER425M, SER433M, SER436M, SER567L, SER69L, THR159L, THR169M, THR174L, THR309M, THR395M, THR401M, THR422M, THR426M, THR66L, TRP143L, TRP217L, TRP243M, TRP303M, TRP378M, TRP383M, TRP558L, TRP65L, TRP67L, TYR119L, TYR140L, TYR151L, TYR157L, TYR158L, TYR177M, TYR189L, TYR300M, TYR317M, TYR338M, TYR435M, TYR444M, TYR481M, VAL129L, VAL146L, VAL172L, VAL173L, VAL176L, VAL179L, VAL233M, VAL237M, VAL238M, VAL320M, VAL393M, VAL405M, VAL417M, VAL420M, VAL423M, VAL430M, VAL434M, VAL472M, VAL473M, VAL476M, VAL550L, VAL70L
• L-N: ALA155N, ALA164N, ALA165N, ALA166N, ALA205N, ALA268N, ALA279N, ALA288N, ALA573L, ALA579L, ALA596L, ALA602L, ALA607L, ARG270N, ARG296N, ARG427N, ARG577L, ARG592L, ASN199N, ASN285N, ASN588L, ASP229N, GLN291N, GLU154N, GLU200N, GLU267N, GLU587L, GLY173N, GLY206N, GLY208N, GLY213N, GLY215N, GLY284N, GLY580L, GLY582L, GLY589L, GLY601L, HIS224N, ILE157N, ILE161N, ILE211N, ILE269N, ILE275N, ILE276N, ILE282N, ILE303N, ILE420N, ILE600L, LEU162N, LEU170N, LEU176N, LEU202N, LEU203N, LEU204N, LEU209N, LEU225N, LEU273N, LEU286N, LEU289N, LEU575L, LEU583L, LEU584L, LEU585L, LEU591L, LEU606L, LEU608L, LEU609L, LEU612L, LYS158N, LYS217N, LYS581L, MET210N, MET287N, MET598L, MET610L, PHE169N, PHE172N, PHE207N, PHE216N, PHE223N, PHE258N, PHE283N, PHE578L, PRO201N, PRO222N, PRO228N, PRO572L, SER156N, SER163N, SER167N, SER168N, SER266N, SER290N, SER576L, SER586L, SER597L, SER599L, THR160N, THR227N, THR292N, TRP226N, TRP593L, TYR159N, TYR300N, TYR423N, TYR590L, TYR594L, VAL212N, VAL221N, VAL230N, VAL263N, VAL271N, VAL272N, VAL416N, VAL574L, VAL595L, VAL603L, VAL604L, VAL605L, VAL611L
• L-K: ALA596L, ALA602L, ARG25K, ARG26K, ARG592L, ARG99K, ASN27K, ASN588L, ASN91K, ASP93K, GLU587L, GLU97K, GLY100K, GLY21K, GLY589L, ILE24K, ILE600L, ILE92K, LEU19K, LEU22K, LEU28K, LEU35K, LEU583L, LEU584L, LEU585L, LEU591L, LEU606L, MET31K, MET38K, MET598L, MET98K, PHE15K, SER586L, SER597L, SER599L, SER94K, SER96K, THR20K, TRP593L, TYR590L, TYR594L, VAL16K, VAL23K, VAL595L, VAL603L, VAL95K
• L-J: ALA101J, ALA110J, ALA596L, ALA602L, ALA607L, ARG592L, GLY601L, ILE102J, ILE107J, ILE111J, ILE600L, ILE98J, LEU104J, LEU606L, LEU608L, LEU609L, LEU99J, MET103J, MET598L, MET610L, PRO96J, SER100J, SER597L, SER599L, TRP593L, TRP87J, TRP93J, TYR109J, VAL105J, VAL106J, VAL108J, VAL595L, VAL603L, VAL604L, VAL605L, VAL611L, VAL92J
• L-E: ALA206L, LEU203L, TRP125E
• L-F: ARG163F, ASN190L, ASP72L, GLU166F, GLY165F, GLY71L
• M-N: ALA155M, ALA171M, ALA180M, ALA188M, ALA191M, ALA325N, ALA374N, ALA384N, ALA400N, ALA405N, ALA413N, ALA419N, ALA429N, ALA436N, ARG167M, ARG22M, ARG363N, ARG427N, ARG479N, ARG74M, ASN198M, GLN179M, GLN404N, GLN472N, GLU110M, GLU144M, GLU320N, GLU324N, GLY182M, GLY319N, GLY364N, GLY385N, GLY402N, GLY412N, GLY417N, GLY421N, GLY468N, GLY76M, HIS406N, HIS435N, ILE154M, ILE168M, ILE176M, ILE187M, ILE189M, ILE371N, ILE386N, ILE393N, ILE420N, ILE475N, ILE72M, ILE77M, ILE79M, LEU138M, LEU147M, LEU156M, LEU183M, LEU186M, LEU190M, LEU192M, LEU222M, LEU223M, LEU289N, LEU381N, LEU399N, LEU407N, LEU422N, LEU426N, LEU432N, LEU434N, LEU465N, LYS111M, LYS173M, LYS395N, MET136M, MET145M, MET146M, MET321N, MET380N, MET388N, MET69M, PHE115M, PHE11M, PHE137M, PHE140M, PHE141M, PHE142M, PHE152M, PHE175M, PHE194M, PHE205M, PHE366N, PHE392N, PHE396N, PHE75M, PRO149M, PRO370N, PRO387N, PRO471N, PRO473N, PRO70M, PRO73M, SER181M, SER322N, SER418N, SER431N, SER476N, SER78M, THR166M, THR169M, THR172M, THR178M, THR318N, THR377N, THR389N, TRP122M, TRP143M, TRP157M, TRP18M, TRP203M, TRP367N, TRP408N, TRP470N, TRP71M, TYR112M, TYR151M, TYR177M, TYR197M, TYR308N, TYR397N, TYR423N, TYR424N, TYR425N, TYR433N, VAL148M, VAL184M, VAL193M, VAL195M, VAL219M, VAL328N, VAL378N, VAL398N, VAL401N, VAL403N, VAL411N, VAL414N, VAL415N, VAL416N, VAL428N, VAL430N, VAL469N
• M-D: ALA199M, ALA436D, ALA58M, ARG148D, ARG151D, ARG352D, ARG363D, ASN198M, ASN212M, ASN502M, ASN99D, ASP357D, GLN149D, GLN439D, GLN498M, GLN62M, GLU438D, GLY201M, GLY353D, GLY59M, HIS196M, ILE60M, LEU153D, LEU211M, LEU359D, LYS150D, MET215M, PHE194M, PHE360D, PRO214M, PRO354D, PRO437D, PRO61M, SER216M, SER358D, SER361D, SER503M, SER57M, THR200M, THR213M, TRP499M, TYR197M, TYR351D, VAL195M, VAL202M, VAL219M, VAL501M, VAL504M
• M-G: ALA58M, ARG85G, ARG86G, ARG87G, ASN212M, ASN495M, ASN502M, ASN89G, GLN497M, GLN498M, GLN56M, GLN62M, GLN64M, GLN82G, GLN88G, GLU97G, GLY51M, GLY59M, HIS490M, HIS84G, ILE60M, LEU54M, LEU83G, PRO61M, SER491M, SER53M, SER57M, SER94G, THR55M, TRP63M, VAL95G
• M-E: ARG63E, GLN56M
• M-F: ALA164F, ALA284M, ALA337M, ARG163F, ASN502M, GLN335M, GLN416M, GLN497M, GLN498M, GLU166F, GLU80F, GLY165F, GLY333M, GLY413M, GLY494M, LEU168F, LEU336M, LEU54M, MET291M, PHE500M, SER334M, THR332M, THR55M, TYR331M, TYR338M, VAL167F, VAL417M, VAL501M, VAL504M
• N-K: ALA11K, ALA126N, ALA12K, ALA146N, ALA155N, ALA164N, ALA165N, ALA166N, ALA175N, ALA179N, ALA234N, ALA41K, ALA43K, ALA45K, ALA49K, ALA65K, ALA69K, ALA70K, ALA71K, ALA73K, ALA78K, ARG148N, ARG151N, ARG296N, ARG85K, ARG86K, ARG87K, ARG99K, ASN27K, ASN293N, ASN40K, ASP183N, ASP229N, ASP57K, ASP93K, GLN149N, GLN180N, GLN232N, GLN291N, GLN55K, GLN59K, GLN5K, GLN82K, GLU133N, GLU154N, GLU36K, GLU72K, GLU97K, GLY100K, GLY141N, GLY144N, GLY173N, GLY182N, GLY190N, GLY233N, GLY34K, GLY50K, GLY54K, GLY58K, GLY76K, GLY7K, HIS124N, HIS84K, ILE132N, ILE13K, ILE157N, ILE161N, ILE37K, ILE39K, ILE63K, ILE66K, ILE75K, ILE92K, ILE9K, LEU108N, LEU10K, LEU118N, LEU125N, LEU130N, LEU134N, LEU137N, LEU139N, LEU142N, LEU14K, LEU153N, LEU162N, LEU170N, LEU171N, LEU176N, LEU184N, LEU19K, LEU202N, LEU209N, LEU22K, LEU28K, LEU29K, LEU32K, LEU35K, LEU44K, LEU4K, LEU64K, LEU66N, LEU68K, LEU77K, LEU79K, LEU80K, LEU83K, LEU8K, LEU90K, LYS150N, LYS158N, LYS295N, MET174N, MET287N, MET31K, MET38K, MET61K, MET98K, PHE129N, PHE140N, PHE147N, PHE15K, PHE169N, PHE172N, PHE46K, PRO138N, PRO228N, SER127N, SER136N, SER152N, SER156N, SER163N, SER167N, SER168N, SER181N, SER185N, SER290N, SER42K, SER51K, SER67K, SER74K, SER94K, SER96K, THR160N, THR292N, THR56K, TRP226N, TRP53K, TYR159N, TYR178N, TYR231N, TYR300N, TYR52K, TYR62K, VAL143N, VAL16K, VAL177N, VAL212N, VAL230N, VAL47K, VAL48K, VAL60K, VAL95K
• N-A: ALA112A, ALA29N, ARG119A, ARG31N, ARG32N, ARG61A, ASN101N, ASN37N, ASN7N, ASP100N, ASP103N, GLU102A, GLU104N, GLU94A, GLY113A, GLY18N, GLY96A, GLY99A, ILE105A, ILE120A, ILE28N, ILE3N, LEU107N, LEU108N, LEU110A, LEU111A, LEU114A, LEU117A, LEU130N, LEU15N, LEU19N, LEU26N, LEU62A, LEU8N, MET1N, MET25N, PHE108A, PHE74A, PRO5N, SER27N, SER95A, THR2N, THR4N, THR64N, TRP30N, TRP97A, TYR116A, TYR84A, VAL101A, VAL109A, VAL115A, VAL118A, VAL21N, VAL22N, VAL23N, VAL24N, VAL98A
• N-J: ALA110J, ALA112N, ALA126N, ALA140J, ALA144J, ALA146N, ALA150J, ALA155J, ALA164J, ALA179N, ALA205N, ARG148N, ARG160J, ARG163J, ARG32N, ASN101N, ASN115J, ASN121N, ASN7N, ASN99N, ASP100N, ASP103N, ASP116J, ASP183N, GLN180N, GLU104N, GLU133N, GLU142J, GLU161J, GLU162J, GLU200N, GLY113J, GLY115N, GLY131N, GLY135J, GLY141N, GLY144N, GLY151J, GLY165J, GLY173N, GLY18N, GLY206N, HIS124N, HIS157J, ILE107J, ILE111J, ILE111N, ILE117N, ILE132N, ILE135N, ILE157N, ILE28N, ILE3N, LEU104J, LEU107N, LEU108N, LEU110N, LEU112J, LEU114N, LEU118N, LEU119N, LEU11N, LEU125N, LEU130N, LEU133J, LEU134N, LEU137N, LEU139J, LEU139N, LEU142N, LEU143J, LEU147J, LEU148J, LEU149J, LEU14N, LEU152J, LEU153N, LEU15N, LEU176N, LEU184N, LEU19N, LEU202N, LEU203N, LEU204N, LEU209N, LEU26N, LEU66N, LEU8N, LEU95N, LEU99J, LYS102N, MET103J, MET146J, MET1N, MET25N, MET67N, PHE105N, PHE129N, PHE134J, PHE140N, PHE147N, PHE156J, PHE169N, PHE172N, PRO136J, PRO138N, PRO201N, PRO235N, PRO65N, SER127N, SER136N, SER145J, SER152N, SER156N, SER181N, SER185N, THR132J, THR160N, THR20N, THR2N, THR64N, TRP94N, TYR106N, TYR109J, TYR137J, TYR145N, TYR178N, TYR98N, VAL106J, VAL108J, VAL109N, VAL114J, VAL138J, VAL141J, VAL143N, VAL153J, VAL154J, VAL158J, VAL177N, VAL17N, VAL212N, VAL21N, VAL22N, VAL23N, VAL24N, VAL63N
• N-B: PRO161B, THR159B, THR2N, THR4N
• N-C: ALA122N, ALA188N, ALA448C, ALA453C, ALA60N, ARG256N, ARG365C, ARG372C, ARG68N, ASN121N, ASN123N, ASN7N, ASP183N, ASP62N, GLN451C, GLN455C, GLN6N, GLY182N, GLY446C, GLY59N, HIS124N, HIS367C, ILE366C, ILE3N, ILE452C, LEU184N, LEU457C, LEU484N, LEU66N, LYS191N, LYS380C, LYS447C, LYS449C, MET1N, MET373C, MET485N, MET61N, MET67N, PHE186N, PRO458C, PRO65N, SER127N, SER185N, SER450C, SER454C, THR2N, THR368C, THR4N, THR64N, TYR260N, VAL187N, VAL63N, VAL69N
• N-D: GLN404N, GLU438D, HIS406N, THR318N
• K-A: ALA65K, ALA66A, ALA69K, ALA70K, ALA71K, ALA73K, ALA78K, ALA87A, ARG63A, ARG85K, ASP79A, GLN59K, GLN82K, GLU72K, GLU81A, GLY76K, HIS84K, ILE63K, ILE66K, ILE75K, ILE77A, LEU32K, LEU64K, LEU68K, LEU70A, LEU77K, LEU79K, LEU80K, LEU81K, LEU83A, LYS67A, MET61K, MET73A, PHE106A, PHE68A, PHE74A, PHE86A, SER65A, SER67K, SER74K, TYR62K, TYR69A, TYR84A, VAL60K, VAL76A, VAL80A
• K-J: ALA101J, ALA110J, ALA11K, ALA126J, ALA128J, ALA12J, ALA12K, ALA140J, ALA144J, ALA150J, ALA155J, ALA15J, ALA164J, ALA28J, ALA38J, ALA41K, ALA43K, ALA45K, ALA48J, ALA49K, ALA51J, ALA53J, ALA60J, ALA62J, ALA65K, ALA69K, ALA70K, ALA71K, ALA73K, ALA78K, ALA97J, ARG160J, ARG163J, ARG18J, ARG25K, ARG26K, ARG85J, ARG85K, ARG86K, ARG87K, ASN115J, ASN24J, ASN27K, ASN40K, ASN75J, ASN89K, ASN91K, ASP116J, ASP120J, ASP57K, ASP93K, CYS8J, GLN117J, GLN55K, GLN59K, GLN5K, GLN82K, GLN83J, GLN86J, GLN88K, GLN91J, GLU161J, GLU162J, GLU2J, GLU36K, GLU55J, GLU72K, GLU80J, GLU84J, GLY113J, GLY118J, GLY121J, GLY130J, GLY135J, GLY151J, GLY159J, GLY165J, GLY18K, GLY21K, GLY34K, GLY47J, GLY50K, GLY52J, GLY54K, GLY58K, GLY76K, GLY77J, GLY78J, GLY7K, GLY95J, GLY9J, HIS157J, HIS22J, HIS27J, HIS6K, HIS84K, ILE102J, ILE107J, ILE111J, ILE119J, ILE11J, ILE124J, ILE131J, ILE13J, ILE13K, ILE20J, ILE24K, ILE2K, ILE33K, ILE37K, ILE39J, ILE39K, ILE56J, ILE63J, ILE63K, ILE66K, ILE75K, ILE81J, ILE92K, ILE94J, ILE98J, ILE9K, LEU104J, LEU10J, LEU10K, LEU112J, LEU133J, LEU143J, LEU147J, LEU148J, LEU149J, LEU14J, LEU14K, LEU152J, LEU17J, LEU17K, LEU19K, LEU22K, LEU28K, LEU29J, LEU29K, LEU32J, LEU32K, LEU35K, LEU36J, LEU37J, LEU44K, LEU46J, LEU4K, LEU54J, LEU64K, LEU66J, LEU68K, LEU74J, LEU76J, LEU77K, LEU79K, LEU80K, LEU81K, LEU83K, LEU88J, LEU8K, LEU90K, LEU99J, LYS127J, LYS89J, MET103J, MET146J, MET1J, MET1K, MET31K, MET38K, MET61K, MET64J, MET72J, MET73J, PHE134J, PHE156J, PHE15K, PHE30K, PHE3J, PHE43J, PHE44J, PHE46K, PHE50J, PHE5J, PHE67J, PHE69J, PRO123J, PRO136J, PRO25J, PRO3K, PRO90J, PRO96J, SER100J, SER125J, SER145J, SER35J, SER40J, SER42K, SER45J, SER51K, SER67K, SER74K, SER79J, THR122J, THR132J, THR16J, THR20K, THR21J, THR23J, THR56K, TRP53K, TRP87J, TRP93J, TYR109J, TYR137J, TYR49J, TYR52K, TYR59J, TYR62K, TYR6J, VAL105J, VAL106J, VAL108J, VAL114J, VAL129J, VAL141J, VAL153J, VAL154J, VAL158J, VAL16K, VAL19J, VAL23K, VAL26J, VAL42J, VAL47K, VAL48K, VAL58J, VAL60K, VAL65J, VAL68J, VAL70J, VAL71J, VAL92J
• K-C: GLN455C, GLN55K, GLU456C
• A-J: ALA103A, ALA104A, ALA112A, ALA122A, ALA126J, ALA128J, ALA140J, ALA144J, ALA150J, ALA155J, ALA164J, ALA23A, ALA41A, ALA43A, ALA51J, ALA53J, ALA60J, ALA62J, ALA66A, ALA72A, ALA82A, ALA87A, ARG160J, ARG163J, ARG40A, ARG42A, ARG61A, ARG63A, ARG93A, ASN75J, ASP124A, ASP79A, CYS27A, CYS28A, GLU102A, GLU142J, GLU161J, GLU162J, GLU166J, GLU55J, GLU81A, GLU94A, GLY113A, GLY121A, GLY130J, GLY135J, GLY151J, GLY159J, GLY165J, GLY25A, GLY33A, GLY34A, GLY38A, GLY39A, GLY41J, GLY52J, GLY61J, GLY77J, GLY78J, GLY96A, GLY99A, HIS157J, ILE105A, ILE107A, ILE120A, ILE131J, ILE21A, ILE24A, ILE33J, ILE34J, ILE56J, ILE57J, ILE63J, ILE77A, ILE92A, LEU110A, LEU111A, LEU114A, LEU117A, LEU133J, LEU139J, LEU143J, LEU147J, LEU148J, LEU149J, LEU152J, LEU168J, LEU20A, LEU26A, LEU29A, LEU29J, LEU30J, LEU31A, LEU36J, LEU37A, LEU37J, LEU54J, LEU62A, LEU64A, LEU66J, LEU70A, LEU74J, LEU76J, LEU83A, LEU85A, LYS127J, LYS67A, MET146J, MET30A, MET64J, MET72J, MET73A, MET73J, PHE100A, PHE106A, PHE134J, PHE156J, PHE16A, PHE19A, PHE36A, PHE44J, PHE50J, PHE67J, PHE68A, PHE69J, PHE74A, PHE75A, PHE78A, PHE86A, PRO136J, SER125J, SER145J, SER40J, SER65A, SER89A, SER91A, SER95A, THR126A, THR132J, THR90A, TRP125A, TRP35A, TRP88A, TYR116A, TYR137J, TYR49J, TYR59J, TYR69A, TYR84A, VAL101A, VAL109A, VAL118A, VAL129J, VAL138J, VAL141J, VAL153J, VAL154J, VAL158J, VAL22A, VAL26J, VAL32A, VAL58J, VAL65J, VAL68J, VAL70J, VAL71A, VAL71J, VAL76A, VAL80A, VAL98A
• A-B: ARG93A, GLU110B, GLU359B, HIS357B, HIS358B, LYS162B, TRP97A
• J-C: LYS449C, PRO136J
• B-C: ALA165B, ALA166B, ALA167B, ALA170B, ALA182B, ALA184B, ALA19B, ALA302C, ALA305C, ALA307C, ALA337C, ALA386C, ALA392C, ALA394C, ALA432C, ALA438C, ALA448C, ALA557B, ALA573B, ARG115B, ARG175B, ARG22B, ARG24B, ARG313C, ARG372C, ARG442C, ARG562B, ARG577B, ASN163B, ASN190B, ASN566B, ASN570B, ASN74B, ASP160B, ASP163C, ASP178B, ASP246C, ASP487C, ASP563B, ASP72B, CYS149B, GLN308C, GLN335C, GLN339C, GLN416C, GLN483C, GLU111B, GLU144B, GLU191B, GLU407C, GLY112B, GLY142B, GLY145B, GLY147B, GLY155B, GLY164B, GLY177B, GLY193B, GLY242C, GLY297C, GLY301C, GLY340C, GLY375C, GLY376C, GLY397C, GLY400C, GLY402C, GLY406C, GLY413C, GLY428C, GLY446C, GLY479C, GLY555B, GLY71B, GLY76B, HIS241C, HIS441C, HIS490C, ILE176C, ILE187B, ILE296C, ILE343C, ILE410C, ILE421C, ILE424C, ILE493C, ILE556B, ILE75B, ILE8B, LEU122B, LEU12B, LEU136B, LEU137B, LEU138B, LEU141B, LEU148B, LEU152B, LEU181B, LEU185B, LEU188B, LEU192B, LEU195B, LEU240C, LEU244C, LEU336C, LEU377C, LEU387C, LEU389C, LEU396C, LEU411C, LEU429C, LEU437C, LEU440C, LEU465C, LEU469C, LEU477C, LEU478C, LEU486C, LEU554B, LEU559B, LEU560B, LEU565B, LEU64B, LYS162B, LYS165C, LYS169B, LYS173C, LYS229B, LYS380C, LYS382C, LYS447C, LYS561B, MET139B, MET168B, MET214B, MET221B, MET304C, MET381C, MET398C, MET409C, MET568B, MET569B, MET68B, PHE156B, PHE15B, PHE171B, PHE180B, PHE183B, PHE186B, PHE20B, PHE299C, PHE306C, PHE325C, PHE390C, PHE404C, PHE408C, PHE412C, PHE415C, PHE427C, PHE431C, PHE445C, PHE480C, PHE549B, PHE553B, PHE73B, PHE77B, PRO161B, PRO239C, PRO245C, PRO385C, PRO399C, PRO419C, PRO482C, PRO484C, PRO552B, PRO564B, PRO572B, SER126B, SER334C, SER379C, SER414C, SER425C, SER433C, SER436C, SER567B, SER576B, SER69B, THR159B, THR169C, THR174B, THR309C, THR395C, THR401C, THR422C, THR426C, THR66B, TRP143B, TRP217B, TRP243C, TRP303C, TRP378C, TRP383C, TRP558B, TRP65B, TRP67B, TYR119B, TYR140B, TYR151B, TYR157B, TYR158B, TYR177C, TYR189B, TYR300C, TYR317C, TYR338C, TYR435C, TYR444C, TYR481C, VAL129B, VAL146B, VAL172B, VAL173B, VAL176B, VAL179B, VAL233C, VAL237C, VAL238C, VAL320C, VAL393C, VAL405C, VAL417C, VAL420C, VAL423C, VAL430C, VAL434C, VAL472C, VAL473C, VAL476C, VAL550B, VAL70B
• B-D: ALA155D, ALA164D, ALA165D, ALA166D, ALA205D, ALA268D, ALA279D, ALA288D, ALA419D, ALA573B, ALA579B, ALA596B, ALA602B, ALA607B, ARG270D, ARG296D, ARG427D, ARG577B, ARG592B, ASN199D, ASN285D, ASN588B, ASP229D, GLN291D, GLU154D, GLU200D, GLU267D, GLU587B, GLY173D, GLY206D, GLY208D, GLY213D, GLY215D, GLY284D, GLY580B, GLY582B, GLY589B, GLY601B, HIS224D, ILE157D, ILE161D, ILE211D, ILE269D, ILE275D, ILE276D, ILE282D, ILE303D, ILE420D, ILE600B, LEU162D, LEU170D, LEU176D, LEU202D, LEU203D, LEU204D, LEU209D, LEU225D, LEU273D, LEU286D, LEU289D, LEU575B, LEU583B, LEU584B, LEU585B, LEU591B, LEU606B, LEU608B, LEU609B, LEU612B, LYS158D, LYS217D, LYS581B, MET210D, MET287D, MET598B, MET610B, PHE169D, PHE172D, PHE207D, PHE216D, PHE223D, PHE258D, PHE283D, PHE578B, PRO201D, PRO222D, PRO228D, PRO572B, SER156D, SER163D, SER167D, SER168D, SER266D, SER290D, SER576B, SER586B, SER597B, SER599B, THR160D, THR227D, THR292D, TRP226D, TRP593B, TYR159D, TYR300D, TYR423D, TYR590B, TYR594B, VAL212D, VAL221D, VAL230D, VAL263D, VAL271D, VAL272D, VAL416D, VAL574B, VAL595B, VAL603B, VAL604B, VAL605B, VAL611B
• B-G: ALA596B, ALA602B, ARG25G, ARG26G, ARG592B, ARG99G, ASN27G, ASN588B, ASN91G, ASP93G, GLU587B, GLU97G, GLY100G, GLY21G, GLY589B, ILE24G, ILE600B, ILE92G, LEU19G, LEU22G, LEU28G, LEU35G, LEU583B, LEU584B, LEU585B, LEU591B, LEU606B, MET31G, MET38G, MET598B, MET98G, PHE15G, SER586B, SER597B, SER599B, SER94G, SER96G, THR20G, TRP593B, TYR590B, TYR594B, VAL16G, VAL23G, VAL595B, VAL603B, VAL95G
• B-F: ALA101F, ALA110F, ALA596B, ALA602B, ALA607B, ARG592B, GLY601B, ILE102F, ILE107F, ILE111F, ILE600B, ILE98F, LEU104F, LEU606B, LEU608B, LEU609B, LEU99F, MET103F, MET598B, MET610B, PRO96F, SER100F, SER597B, SER599B, TRP593B, TRP87F, TRP93F, TYR109F, VAL105F, VAL106F, VAL108F, VAL595B, VAL603B, VAL604B, VAL605B, VAL611B, VAL92F
• C-D: ALA155C, ALA171C, ALA180C, ALA188C, ALA191C, ALA325D, ALA374D, ALA384D, ALA400D, ALA405D, ALA413D, ALA419D, ALA429D, ALA436D, ARG167C, ARG22C, ARG363D, ARG427D, ARG479D, ARG74C, ASN198C, GLN179C, GLN404D, GLN472D, GLU110C, GLU144C, GLU320D, GLU324D, GLY182C, GLY319D, GLY364D, GLY385D, GLY402D, GLY412D, GLY417D, GLY421D, GLY468D, GLY76C, HIS406D, HIS435D, ILE154C, ILE168C, ILE176C, ILE187C, ILE189C, ILE371D, ILE386D, ILE393D, ILE420D, ILE475D, ILE72C, ILE77C, ILE79C, LEU138C, LEU147C, LEU156C, LEU183C, LEU186C, LEU190C, LEU192C, LEU222C, LEU223C, LEU289D, LEU381D, LEU399D, LEU407D, LEU422D, LEU426D, LEU432D, LEU434D, LEU465D, LYS111C, LYS173C, LYS395D, MET145C, MET146C, MET321D, MET380D, MET388D, MET69C, PHE115C, PHE11C, PHE137C, PHE140C, PHE141C, PHE142C, PHE152C, PHE175C, PHE194C, PHE205C, PHE366D, PHE392D, PHE396D, PHE75C, PRO149C, PRO370D, PRO387D, PRO471D, PRO473D, PRO70C, PRO73C, SER181C, SER322D, SER418D, SER431D, SER476D, SER78C, THR166C, THR169C, THR172C, THR178C, THR318D, THR377D, THR389D, TRP122C, TRP143C, TRP157C, TRP18C, TRP203C, TRP367D, TRP408D, TRP470D, TRP71C, TYR112C, TYR151C, TYR177C, TYR197C, TYR308D, TYR397D, TYR423D, TYR424D, TYR425D, TYR433D, VAL148C, VAL184C, VAL193C, VAL195C, VAL219C, VAL328D, VAL378D, VAL398D, VAL401D, VAL403D, VAL411D, VAL414D, VAL415D, VAL416D, VAL428D, VAL430D, VAL469D
• D-G: ALA11G, ALA126D, ALA12G, ALA146D, ALA155D, ALA164D, ALA165D, ALA166D, ALA175D, ALA179D, ALA234D, ALA41G, ALA43G, ALA45G, ALA49G, ALA65G, ALA69G, ALA70G, ALA71G, ALA73G, ALA78G, ARG148D, ARG151D, ARG296D, ARG85G, ARG86G, ARG87G, ARG99G, ASN27G, ASN293D, ASN40G, ASP183D, ASP229D, ASP57G, ASP93G, GLN149D, GLN180D, GLN232D, GLN291D, GLN55G, GLN59G, GLN5G, GLN82G, GLU133D, GLU154D, GLU36G, GLU72G, GLU97G, GLY100G, GLY141D, GLY144D, GLY173D, GLY182D, GLY18G, GLY190D, GLY233D, GLY34G, GLY50G, GLY54G, GLY58G, GLY76G, GLY7G, HIS124D, HIS84G, ILE132D, ILE13G, ILE157D, ILE161D, ILE37G, ILE39G, ILE63G, ILE66G, ILE75G, ILE92G, ILE9G, LEU108D, LEU10G, LEU118D, LEU125D, LEU130D, LEU134D, LEU137D, LEU139D, LEU142D, LEU14G, LEU153D, LEU162D, LEU170D, LEU171D, LEU176D, LEU184D, LEU19G, LEU202D, LEU209D, LEU225D, LEU22G, LEU28G, LEU29G, LEU32G, LEU35G, LEU44G, LEU4G, LEU64G, LEU66D, LEU68G, LEU77G, LEU79G, LEU80G, LEU83G, LEU8G, LEU90G, LYS150D, LYS158D, LYS295D, MET174D, MET287D, MET31G, MET38G, MET61G, MET98G, PHE129D, PHE140D, PHE147D, PHE15G, PHE169D, PHE172D, PHE46G, PRO138D, PRO228D, SER127D, SER136D, SER152D, SER156D, SER163D, SER167D, SER168D, SER181D, SER290D, SER42G, SER51G, SER67G, SER74G, SER94G, SER96G, THR160D, THR292D, THR56G, TRP226D, TRP53G, TYR159D, TYR178D, TYR231D, TYR300D, TYR52G, TYR62G, VAL143D, VAL16G, VAL177D, VAL212D, VAL230D, VAL47G, VAL48G, VAL60G, VAL95G
• D-E: ALA112E, ALA29D, ARG119E, ARG31D, ARG32D, ARG61E, ASN101D, ASN37D, ASN7D, ASP100D, ASP103D, GLU102E, GLU104D, GLU94E, GLY113E, GLY18D, GLY96E, GLY99E, ILE105E, ILE120E, ILE28D, ILE3D, LEU107D, LEU108D, LEU110E, LEU111E, LEU114E, LEU117E, LEU130D, LEU15D, LEU19D, LEU26D, LEU62E, LEU8D, MET1D, MET25D, PHE108E, PHE74E, PRO5D, SER27D, SER95E, THR2D, THR4D, THR64D, TRP30D, TRP97E, TYR116E, TYR84E, VAL101E, VAL109E, VAL115E, VAL118E, VAL21D, VAL22D, VAL23D, VAL24D, VAL98E
• D-F: ALA110F, ALA112D, ALA126D, ALA140F, ALA144F, ALA146D, ALA150F, ALA155F, ALA164F, ALA179D, ALA205D, ARG148D, ARG160F, ARG163F, ARG32D, ASN101D, ASN115F, ASN121D, ASN7D, ASN99D, ASP100D, ASP103D, ASP116F, GLN180D, GLU104D, GLU133D, GLU142F, GLU161F, GLU162F, GLU200D, GLY113F, GLY115D, GLY131D, GLY135F, GLY141D, GLY144D, GLY151F, GLY165F, GLY173D, GLY182D, GLY18D, GLY206D, HIS124D, HIS157F, ILE107F, ILE111D, ILE111F, ILE117D, ILE132D, ILE135D, ILE157D, ILE28D, ILE3D, LEU104F, LEU107D, LEU108D, LEU110D, LEU112F, LEU114D, LEU118D, LEU119D, LEU11D, LEU125D, LEU130D, LEU133F, LEU134D, LEU137D, LEU139D, LEU139F, LEU142D, LEU143F, LEU147F, LEU148F, LEU149F, LEU14D, LEU152F, LEU153D, LEU15D, LEU176D, LEU184D, LEU19D, LEU202D, LEU203D, LEU204D, LEU209D, LEU26D, LEU66D, LEU8D, LEU95D, LEU99F, LYS102D, MET103F, MET146F, MET1D, MET25D, MET67D, PHE105D, PHE129D, PHE134F, PHE140D, PHE147D, PHE156F, PHE169D, PHE172D, PRO136F, PRO138D, PRO201D, PRO235D, PRO65D, SER100F, SER127D, SER136D, SER145F, SER156D, SER181D, THR132F, THR160D, THR20D, THR2D, THR64D, TRP94D, TYR106D, TYR109F, TYR137F, TYR145D, TYR178D, TYR98D, VAL106F, VAL108F, VAL109D, VAL114F, VAL138F, VAL141F, VAL143D, VAL153F, VAL154F, VAL158F, VAL177D, VAL17D, VAL212D, VAL21D, VAL22D, VAL23D, VAL24D, VAL63D
• G-E: ALA65G, ALA66E, ALA69G, ALA70G, ALA71G, ALA73G, ALA78G, ALA87E, ARG63E, ARG85G, ASP79E, GLN59G, GLN82G, GLU72G, GLU81E, GLY76G, HIS84G, ILE63G, ILE66G, ILE75G, ILE77E, LEU32G, LEU64G, LEU68G, LEU70E, LEU77G, LEU79G, LEU80G, LEU81G, LEU83E, LYS67E, MET61G, MET73E, PHE106E, PHE68E, PHE74E, PHE86E, SER65E, SER67G, SER74G, TYR62G, TYR69E, TYR84E, VAL60G, VAL76E, VAL80E
• G-F: ALA101F, ALA110F, ALA11G, ALA126F, ALA128F, ALA12F, ALA12G, ALA140F, ALA144F, ALA150F, ALA155F, ALA15F, ALA164F, ALA28F, ALA38F, ALA41G, ALA43G, ALA45G, ALA48F, ALA49G, ALA51F, ALA53F, ALA60F, ALA62F, ALA65G, ALA69G, ALA70G, ALA71G, ALA73G, ALA78G, ALA97F, ARG160F, ARG163F, ARG18F, ARG25G, ARG26G, ARG85F, ARG85G, ARG86G, ARG87G, ASN115F, ASN24F, ASN27G, ASN40G, ASN75F, ASN89G, ASN91G, ASP116F, ASP120F, ASP57G, ASP93G, CYS8F, GLN117F, GLN55G, GLN59G, GLN5G, GLN82G, GLN83F, GLN86F, GLN88G, GLN91F, GLU161F, GLU162F, GLU2F, GLU36G, GLU55F, GLU72G, GLU80F, GLU84F, GLY113F, GLY118F, GLY121F, GLY130F, GLY135F, GLY151F, GLY159F, GLY165F, GLY18G, GLY21G, GLY34G, GLY47F, GLY50G, GLY52F, GLY54G, GLY58G, GLY76G, GLY77F, GLY78F, GLY7G, GLY95F, GLY9F, HIS157F, HIS22F, HIS27F, HIS6G, HIS84G, ILE102F, ILE107F, ILE111F, ILE119F, ILE11F, ILE124F, ILE131F, ILE13F, ILE13G, ILE20F, ILE24G, ILE2G, ILE33G, ILE37G, ILE39F, ILE39G, ILE56F, ILE63F, ILE63G, ILE66G, ILE75G, ILE81F, ILE92G, ILE94F, ILE98F, ILE9G, LEU104F, LEU10F, LEU10G, LEU112F, LEU133F, LEU143F, LEU147F, LEU148F, LEU149F, LEU14F, LEU14G, LEU152F, LEU17F, LEU17G, LEU19G, LEU22G, LEU28G, LEU29F, LEU29G, LEU32F, LEU32G, LEU35G, LEU36F, LEU37F, LEU44G, LEU46F, LEU4G, LEU54F, LEU64G, LEU66F, LEU68G, LEU74F, LEU76F, LEU77G, LEU79G, LEU80G, LEU81G, LEU83G, LEU88F, LEU8G, LEU90G, LEU99F, LYS127F, LYS89F, MET103F, MET146F, MET1F, MET1G, MET31G, MET38G, MET61G, MET64F, MET72F, MET73F, PHE134F, PHE156F, PHE15G, PHE30G, PHE3F, PHE43F, PHE44F, PHE46G, PHE50F, PHE5F, PHE67F, PHE69F, PRO123F, PRO136F, PRO25F, PRO3G, PRO90F, PRO96F, SER100F, SER125F, SER145F, SER35F, SER40F, SER42G, SER45F, SER51G, SER67G, SER74G, SER79F, THR122F, THR132F, THR16F, THR20G, THR21F, THR23F, THR56G, TRP53G, TRP87F, TRP93F, TYR109F, TYR137F, TYR49F, TYR52G, TYR59F, TYR62G, TYR6F, VAL105F, VAL106F, VAL108F, VAL114F, VAL129F, VAL141F, VAL153F, VAL154F, VAL158F, VAL16G, VAL19F, VAL23G, VAL26F, VAL42F, VAL47G, VAL48G, VAL58F, VAL60G, VAL65F, VAL68F, VAL70F, VAL71F, VAL92F
• E-F: ALA103E, ALA104E, ALA112E, ALA122E, ALA126F, ALA128F, ALA140F, ALA144F, ALA150F, ALA155F, ALA164F, ALA23E, ALA41E, ALA43E, ALA51F, ALA53F, ALA60F, ALA62F, ALA66E, ALA72E, ALA82E, ALA87E, ARG160F, ARG163F, ARG40E, ARG42E, ARG61E, ARG63E, ARG93E, ASN75F, ASP124E, ASP79E, CYS27E, CYS28E, CYS8F, GLU102E, GLU142F, GLU161F, GLU162F, GLU166F, GLU55F, GLU81E, GLU94E, GLY113E, GLY121E, GLY130F, GLY135F, GLY151F, GLY159F, GLY165F, GLY25E, GLY33E, GLY34E, GLY38E, GLY39E, GLY41F, GLY52F, GLY61F, GLY77F, GLY78F, GLY96E, GLY99E, HIS157F, ILE105E, ILE107E, ILE120E, ILE131F, ILE21E, ILE24E, ILE33F, ILE34F, ILE56F, ILE57F, ILE63F, ILE77E, ILE92E, LEU110E, LEU111E, LEU114E, LEU117E, LEU133F, LEU139F, LEU143F, LEU147F, LEU148F, LEU149F, LEU152F, LEU168F, LEU20E, LEU26E, LEU29E, LEU29F, LEU30F, LEU31E, LEU36F, LEU37E, LEU37F, LEU54F, LEU62E, LEU64E, LEU66F, LEU70E, LEU74F, LEU76F, LEU83E, LEU85E, LYS127F, LYS67E, MET146F, MET30E, MET64F, MET72F, MET73E, MET73F, PHE100E, PHE106E, PHE134F, PHE156F, PHE16E, PHE19E, PHE36E, PHE44F, PHE50F, PHE67F, PHE68E, PHE69F, PHE74E, PHE75E, PHE78E, PHE86E, PRO136F, SER125F, SER145F, SER40F, SER65E, SER89E, SER91E, SER95E, THR126E, THR132F, THR90E, TRP125E, TRP35E, TRP88E, TYR116E, TYR137F, TYR49F, TYR59F, TYR69E, TYR84E, VAL101E, VAL109E, VAL118E, VAL129F, VAL138F, VAL141F, VAL153F, VAL154F, VAL158F, VAL22E, VAL26F, VAL32E, VAL58F, VAL65F, VAL68F, VAL70F, VAL71E, VAL71F, VAL76E, VAL80E, VAL98E