3RKI

structural basis for immunization with post-fusion rsv f to elicit high neutralizing antibody titers

• Total interactions analyzed: 3
• Total true interactions: 3
• Strongest Interaction:
  • Chains: B-C
  • Int. Res.: 482
  • Norm. En. per Res.: -3.4208
• Hub Node: A(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-201.8939	-44.0277	-1306.66	-1552.5816	487	85	60	60813	8	81	77
A-C	-211.6324	-44.9033	-1351.83	-1608.3657	479	107	57	62328	9	84	74
B-C	-256.2306	-52.3443	-1340.23	-1648.805	482	106	56	61636	8	80	73

Interface residues

• A-B: ALA147A, ALA149A, ALA149B, ALA153A, ALA153B, ALA170A, ALA170B, ALA177A, ALA177B, ALA241A, ALA298A, ALA346A, ALA355B, ALA490A, ALA490B, ALA504A, ALA504B, ALA74A, ALA74B, ALA89A, ARG229A, ARG229B, ARG235A, ARG235B, ARG282B, ARG336B, ARG339B, ARG429B, ARG49A, ARG507A, ARG507B, ASN165A, ASN165B, ASN175A, ASN175B, ASN183A, ASN183B, ASN197A, ASN197B, ASN208A, ASN208B, ASN216A, ASN216B, ASN227A, ASN227B, ASN228B, ASN240A, ASN240B, ASN254B, ASN262A, ASN276B, ASN277B, ASN331B, ASN345A, ASN371A, ASN388A, ASN454B, ASN460B, ASN476A, ASN476B, ASN496A, ASN496B, ASN500A, ASN500B, ASN515A, ASN515B, ASN517A, ASN517B, ASN63A, ASN67A, ASN70A, ASN88A, ASP194A, ASP194B, ASP200A, ASP200B, ASP263A, ASP338A, ASP338B, ASP344A, ASP392A, ASP401B, ASP479A, ASP479B, ASP486A, ASP486B, ASP489A, ASP489B, ASP510A, ASP510B, ASP73A, ASP73B, ASP84A, CYS212A, CYS212B, CYS322B, CYS333B, CYS422B, CYS69A, GLN202A, GLN202B, GLN210A, GLN210B, GLN224A, GLN224B, GLN225A, GLN225B, GLN270A, GLN279B, GLN283B, GLN284B, GLN302A, GLN354A, GLN354B, GLN361B, GLN462B, GLN494A, GLN494B, GLN501A, GLN501B, GLN81A, GLN81B, GLN94A, GLN98A, GLU161A, GLU161B, GLU163A, GLU163B, GLU218A, GLU218B, GLU222A, GLU222B, GLU232A, GLU232B, GLU236A, GLU236B, GLU256A, GLU256B, GLU295A, GLU356A, GLU356B, GLU378A, GLU463B, GLU472B, GLU487A, GLU487B, GLU497A, GLU497B, GLU511A, GLU511B, GLU60A, GLU66A, GLU82A, GLU92A, GLY162A, GLY162B, GLY184A, GLY184B, GLY242A, GLY307A, GLY340B, GLY347A, GLY453B, GLY464B, GLY471B, GLY51A, GLY71A, HIS159A, HIS159B, HIS317B, HIS514A, HIS514B, ILE148A, ILE167A, ILE167B, ILE199A, ILE199B, ILE206A, ILE206B, ILE214A, ILE214B, ILE217A, ILE217B, ILE221A, ILE221B, ILE233A, ILE233B, ILE261A, ILE266A, ILE280B, ILE288A, ILE292A, ILE309A, ILE332B, ILE395B, ILE407B, ILE474A, ILE474B, ILE475A, ILE475B, ILE492A, ILE492B, ILE499A, ILE499B, ILE506A, ILE506B, ILE57A, ILE59A, ILE64A, ILE79A, LEU158A, LEU158B, LEU160A, LEU160B, LEU171A, LEU171B, LEU172A, LEU172B, LEU181A, LEU181B, LEU188A, LEU188B, LEU193A, LEU193B, LEU195A, LEU195B, LEU203A, LEU203B, LEU204A, LEU204B, LEU230A, LEU231A, LEU231B, LEU252A, LEU252B, LEU257A, LEU257B, LEU258A, LEU258B, LEU260A, LEU297A, LEU303A, LEU305A, LEU316B, LEU373A, LEU375A, LEU381A, LEU456B, LEU467B, LEU481A, LEU481B, LEU48A, LEU503A, LEU503B, LEU512A, LEU512B, LEU513A, LEU513B, LEU61A, LEU78A, LEU78B, LEU83A, LEU93A, LEU95A, LEU96A, LYS156A, LYS156B, LYS166A, LYS166B, LYS168A, LYS168B, LYS176A, LYS176B, LYS191A, LYS191B, LYS196A, LYS196B, LYS201A, LYS201B, LYS209A, LYS209B, LYS226A, LYS226B, LYS315B, LYS390A, LYS394A, LYS399B, LYS419B, LYS421B, LYS461B, LYS465B, LYS470B, LYS498A, LYS498B, LYS508A, LYS508B, LYS65A, LYS68A, LYS75A, LYS75B, LYS77A, LYS80A, LYS85A, MET251A, MET251B, MET264A, MET274B, MET289A, MET370A, MET396B, MET97A, PHE223A, PHE223B, PHE237A, PHE351A, PHE477A, PHE477B, PHE483A, PHE483B, PHE488A, PHE488B, PHE505A, PHE505B, PRO205A, PRO205B, PRO246B, PRO265A, PRO304A, PRO320B, PRO353A, PRO353B, PRO376A, PRO389A, PRO473B, PRO480A, PRO480B, PRO484A, PRO484B, SER146A, SER155A, SER169A, SER169B, SER173A, SER173B, SER180A, SER180B, SER182A, SER182B, SER186A, SER186B, SER190A, SER190B, SER211A, SER211B, SER213A, SER213B, SER215A, SER215B, SER238A, SER248B, SER255A, SER255B, SER259A, SER275B, SER285B, SER319B, SER348A, SER350A, SER372A, SER377A, SER398B, SER403B, SER404B, SER405B, SER409B, SER415B, SER451B, SER466B, SER485A, SER485B, SER491A, SER491B, SER493B, SER502A, SER502B, SER509A, SER509B, SER55A, SER62A, THR174A, THR174B, THR189A, THR189B, THR219A, THR219B, THR234A, THR244A, THR244B, THR245B, THR249B, THR253A, THR253B, THR267A, THR311A, THR318B, THR335B, THR337B, THR369A, THR374A, THR397B, THR400B, THR408B, THR420B, THR449B, THR455B, THR50A, THR54A, THR58A, THR72A, THR72B, THR91A, TRP52A, TYR198A, TYR198B, TYR250B, TYR286A, TYR299A, TYR306A, TYR391A, TYR417B, TYR457B, TYR458B, TYR468B, TYR478A, TYR478B, TYR53A, TYR86A, VAL152A, VAL152B, VAL154A, VAL154B, VAL157A, VAL157B, VAL164A, VAL164B, VAL178A, VAL178B, VAL179A, VAL179B, VAL185A, VAL185B, VAL187A, VAL187B, VAL192A, VAL192B, VAL207A, VAL207B, VAL220A, VAL220B, VAL239A, VAL239B, VAL243A, VAL247B, VAL278B, VAL281B, VAL296A, VAL300A, VAL301A, VAL308A, VAL349A, VAL379A, VAL402B, VAL406B, VAL450B, VAL452B, VAL459B, VAL469B, VAL482A, VAL482B, VAL495A, VAL495B, VAL516A, VAL516B, VAL56A, VAL76A, VAL76B, VAL90A
• A-C: ALA147A, ALA149A, ALA153A, ALA153C, ALA170A, ALA170C, ALA177A, ALA177C, ALA241C, ALA298C, ALA346C, ALA355A, ALA490A, ALA490C, ALA504A, ALA504C, ALA74A, ALA74C, ALA89C, ARG229A, ARG229C, ARG235A, ARG235C, ARG282A, ARG336A, ARG339A, ARG429A, ARG49C, ARG507A, ARG507C, ASN165A, ASN165C, ASN175A, ASN175C, ASN183A, ASN183C, ASN197A, ASN197C, ASN208A, ASN208C, ASN216A, ASN216C, ASN227A, ASN227C, ASN228A, ASN240A, ASN240C, ASN254A, ASN262C, ASN276A, ASN277A, ASN345C, ASN371C, ASN388C, ASN454A, ASN460A, ASN476A, ASN476C, ASN496A, ASN496C, ASN500A, ASN500C, ASN515A, ASN515C, ASN517A, ASN517C, ASN63C, ASN67C, ASN70C, ASN88C, ASP194A, ASP194C, ASP200A, ASP200C, ASP263C, ASP338A, ASP338C, ASP344C, ASP392C, ASP401A, ASP479A, ASP479C, ASP486A, ASP486C, ASP489A, ASP489C, ASP510A, ASP510C, ASP73A, ASP73C, ASP84C, CYS212A, CYS212C, CYS333A, CYS393C, CYS69C, GLN202A, GLN202C, GLN210A, GLN210C, GLN224A, GLN224C, GLN225A, GLN225C, GLN270C, GLN279A, GLN283A, GLN284A, GLN302C, GLN354A, GLN354C, GLN361A, GLN462A, GLN494A, GLN494C, GLN501A, GLN501C, GLN81A, GLN81C, GLN94C, GLN98C, GLU161A, GLU161C, GLU163A, GLU163C, GLU218A, GLU218C, GLU222A, GLU222C, GLU232A, GLU232C, GLU236A, GLU236C, GLU256A, GLU256C, GLU295C, GLU356A, GLU356C, GLU378C, GLU463A, GLU472A, GLU487A, GLU487C, GLU497A, GLU497C, GLU511A, GLU511C, GLU60C, GLU66C, GLU82C, GLU92C, GLY162A, GLY184A, GLY184C, GLY242C, GLY307C, GLY340A, GLY347C, GLY453A, GLY464A, GLY471A, GLY51C, GLY71A, GLY71C, HIS159A, HIS159C, HIS317A, HIS514A, HIS514C, ILE148A, ILE167A, ILE167C, ILE199A, ILE199C, ILE206A, ILE206C, ILE214A, ILE214C, ILE217A, ILE217C, ILE221A, ILE221C, ILE233A, ILE233C, ILE261C, ILE266C, ILE280A, ILE288C, ILE309C, ILE332A, ILE395A, ILE407A, ILE474A, ILE474C, ILE475A, ILE475C, ILE492A, ILE492C, ILE499A, ILE499C, ILE506A, ILE506C, ILE57C, ILE59C, ILE64C, ILE79C, LEU158A, LEU158C, LEU160A, LEU160C, LEU171A, LEU171C, LEU172A, LEU172C, LEU181A, LEU181C, LEU188A, LEU188C, LEU193A, LEU193C, LEU195A, LEU195C, LEU203A, LEU203C, LEU204A, LEU204C, LEU230C, LEU231A, LEU231C, LEU252A, LEU252C, LEU257A, LEU257C, LEU258A, LEU258C, LEU260C, LEU297C, LEU303C, LEU305C, LEU316A, LEU373C, LEU375C, LEU381C, LEU456A, LEU467A, LEU481A, LEU481C, LEU48C, LEU503A, LEU503C, LEU512A, LEU512C, LEU513A, LEU513C, LEU61C, LEU78A, LEU78C, LEU83C, LEU93C, LEU95C, LEU96C, LYS156A, LYS156C, LYS166A, LYS166C, LYS168A, LYS168C, LYS176A, LYS176C, LYS191A, LYS191C, LYS196A, LYS196C, LYS201A, LYS201C, LYS209A, LYS209C, LYS226A, LYS226C, LYS315A, LYS390C, LYS394C, LYS399A, LYS419A, LYS421A, LYS461A, LYS465A, LYS470A, LYS498A, LYS498C, LYS508A, LYS508C, LYS65C, LYS68C, LYS75A, LYS75C, LYS77C, LYS80C, LYS85C, MET251A, MET251C, MET264C, MET289C, MET370C, MET396A, MET97C, PHE223A, PHE223C, PHE237C, PHE351C, PHE477A, PHE477C, PHE483A, PHE483C, PHE488A, PHE488C, PHE505A, PHE505C, PRO205A, PRO205C, PRO246A, PRO265C, PRO304C, PRO320A, PRO353A, PRO353C, PRO376C, PRO389C, PRO473A, PRO480A, PRO480C, PRO484A, PRO484C, SER146A, SER155C, SER169A, SER169C, SER173A, SER173C, SER180A, SER180C, SER182A, SER182C, SER186A, SER186C, SER190A, SER190C, SER211A, SER211C, SER213A, SER213C, SER215A, SER215C, SER238C, SER248A, SER255A, SER255C, SER259C, SER275A, SER319A, SER348C, SER350C, SER372C, SER377C, SER398A, SER403A, SER404A, SER405A, SER409A, SER415A, SER451A, SER466A, SER485A, SER485C, SER491A, SER491C, SER493A, SER502A, SER502C, SER509A, SER509C, SER55C, SER62C, THR174A, THR174C, THR189A, THR189C, THR219A, THR219C, THR234C, THR244A, THR244C, THR245A, THR249A, THR253A, THR253C, THR267C, THR311C, THR318A, THR335A, THR337A, THR369C, THR374C, THR397A, THR400A, THR408A, THR420A, THR455A, THR50C, THR54C, THR58C, THR72A, THR72C, THR91C, TRP52C, TYR198A, TYR198C, TYR250A, TYR250C, TYR286C, TYR299C, TYR306C, TYR391C, TYR417A, TYR457A, TYR458A, TYR468A, TYR478A, TYR478C, TYR53C, TYR86C, VAL152A, VAL154A, VAL154C, VAL157A, VAL157C, VAL164A, VAL164C, VAL178A, VAL178C, VAL179A, VAL179C, VAL185A, VAL185C, VAL187A, VAL187C, VAL192A, VAL192C, VAL207A, VAL207C, VAL220A, VAL220C, VAL239A, VAL239C, VAL243C, VAL247A, VAL278A, VAL281A, VAL296C, VAL300C, VAL301C, VAL308C, VAL349C, VAL379C, VAL402A, VAL406A, VAL450A, VAL452A, VAL459A, VAL469A, VAL482A, VAL482C, VAL495A, VAL495C, VAL516A, VAL516C, VAL56C, VAL76A, VAL76C
• B-C: ALA149B, ALA153B, ALA153C, ALA170B, ALA170C, ALA177B, ALA177C, ALA241B, ALA298B, ALA346B, ALA355C, ALA490B, ALA490C, ALA504B, ALA504C, ALA74B, ALA74C, ALA89B, ARG229B, ARG229C, ARG235B, ARG235C, ARG282C, ARG336C, ARG339C, ARG429C, ARG49B, ARG507B, ARG507C, ASN165B, ASN165C, ASN175B, ASN175C, ASN183B, ASN183C, ASN197B, ASN197C, ASN208B, ASN208C, ASN216B, ASN216C, ASN227B, ASN227C, ASN228C, ASN240B, ASN240C, ASN254C, ASN262B, ASN276C, ASN277C, ASN345B, ASN371B, ASN388B, ASN454C, ASN460C, ASN476B, ASN476C, ASN496B, ASN496C, ASN500B, ASN500C, ASN515B, ASN515C, ASN517B, ASN517C, ASN63B, ASN67B, ASN70B, ASN88B, ASP194B, ASP194C, ASP200B, ASP200C, ASP263B, ASP338B, ASP344B, ASP392B, ASP401C, ASP479B, ASP479C, ASP486B, ASP486C, ASP489B, ASP489C, ASP510B, ASP510C, ASP73B, ASP73C, ASP84B, CYS212B, CYS212C, CYS333C, CYS393B, CYS422C, CYS69B, GLN202B, GLN202C, GLN210B, GLN210C, GLN224B, GLN224C, GLN225B, GLN225C, GLN270B, GLN279C, GLN283C, GLN284C, GLN302B, GLN354B, GLN354C, GLN361C, GLN462C, GLN494B, GLN494C, GLN501B, GLN501C, GLN81B, GLN81C, GLN94B, GLN98B, GLU161B, GLU161C, GLU163B, GLU163C, GLU218B, GLU218C, GLU222B, GLU222C, GLU232B, GLU232C, GLU236B, GLU236C, GLU256B, GLU256C, GLU295B, GLU356B, GLU356C, GLU378B, GLU463C, GLU472C, GLU487B, GLU487C, GLU497B, GLU497C, GLU511B, GLU511C, GLU60B, GLU66B, GLU82B, GLU92B, GLY151B, GLY162C, GLY184B, GLY184C, GLY242B, GLY307B, GLY340C, GLY347B, GLY453C, GLY464C, GLY471C, GLY51B, GLY71B, HIS159B, HIS159C, HIS317C, HIS514B, HIS514C, ILE148B, ILE167B, ILE167C, ILE199B, ILE199C, ILE206B, ILE206C, ILE214B, ILE214C, ILE217B, ILE217C, ILE221B, ILE221C, ILE233B, ILE233C, ILE261B, ILE266B, ILE280C, ILE288B, ILE309B, ILE332C, ILE395C, ILE407C, ILE474B, ILE474C, ILE475B, ILE475C, ILE492B, ILE492C, ILE499B, ILE499C, ILE506B, ILE506C, ILE57B, ILE59B, ILE64B, ILE79B, LEU158B, LEU158C, LEU160B, LEU160C, LEU171B, LEU171C, LEU172B, LEU172C, LEU181B, LEU181C, LEU188B, LEU188C, LEU193B, LEU193C, LEU195B, LEU195C, LEU203B, LEU203C, LEU204B, LEU204C, LEU230B, LEU231B, LEU231C, LEU252B, LEU252C, LEU257B, LEU257C, LEU258B, LEU258C, LEU260B, LEU297B, LEU303B, LEU305B, LEU316C, LEU373B, LEU375B, LEU381B, LEU456C, LEU467C, LEU481B, LEU481C, LEU48B, LEU503B, LEU503C, LEU512B, LEU512C, LEU513B, LEU513C, LEU61B, LEU78B, LEU78C, LEU83B, LEU93B, LEU95B, LEU96B, LYS156B, LYS156C, LYS166B, LYS166C, LYS168B, LYS168C, LYS176B, LYS176C, LYS191B, LYS191C, LYS196B, LYS196C, LYS201B, LYS201C, LYS209B, LYS209C, LYS226B, LYS226C, LYS315C, LYS390B, LYS394B, LYS399C, LYS419C, LYS421C, LYS461C, LYS465C, LYS470C, LYS498B, LYS498C, LYS508B, LYS508C, LYS65B, LYS68B, LYS75B, LYS75C, LYS77B, LYS80B, LYS85B, MET251B, MET251C, MET264B, MET274C, MET289B, MET370B, MET396C, MET97B, PHE223B, PHE223C, PHE237B, PHE351B, PHE477B, PHE477C, PHE483B, PHE483C, PHE488B, PHE488C, PHE505B, PHE505C, PRO205B, PRO205C, PRO246C, PRO265B, PRO304B, PRO320C, PRO353B, PRO353C, PRO376B, PRO389B, PRO473C, PRO480B, PRO480C, PRO484B, PRO484C, SER150B, SER155B, SER155C, SER169B, SER169C, SER173B, SER173C, SER180B, SER180C, SER182B, SER182C, SER186B, SER186C, SER190B, SER190C, SER211B, SER211C, SER213B, SER213C, SER215B, SER215C, SER238B, SER248C, SER255B, SER255C, SER259B, SER275C, SER319C, SER348B, SER350B, SER372B, SER377B, SER398C, SER403C, SER404C, SER405C, SER409C, SER415C, SER451C, SER466C, SER46B, SER485C, SER491B, SER491C, SER493C, SER502B, SER502C, SER509B, SER509C, SER55B, SER62B, THR174B, THR174C, THR189B, THR189C, THR219B, THR219C, THR234B, THR244B, THR244C, THR245C, THR249C, THR253B, THR253C, THR267B, THR311B, THR318C, THR335C, THR337C, THR369B, THR374B, THR397C, THR400C, THR408C, THR420C, THR449C, THR455C, THR50B, THR54B, THR58B, THR72B, THR72C, THR91B, TRP52B, TYR198B, TYR198C, TYR250C, TYR286B, TYR299B, TYR306B, TYR391B, TYR417C, TYR457C, TYR458C, TYR468C, TYR478B, TYR478C, TYR53B, TYR86B, VAL152B, VAL152C, VAL154B, VAL154C, VAL157B, VAL157C, VAL164B, VAL164C, VAL178B, VAL178C, VAL179B, VAL179C, VAL185B, VAL185C, VAL187B, VAL187C, VAL192B, VAL192C, VAL207B, VAL207C, VAL220B, VAL220C, VAL239B, VAL239C, VAL243B, VAL247C, VAL278C, VAL281C, VAL296B, VAL300B, VAL301B, VAL308B, VAL349B, VAL379B, VAL402C, VAL406C, VAL450C, VAL452C, VAL459C, VAL469C, VAL482B, VAL482C, VAL495B, VAL495C, VAL516B, VAL516C, VAL56B, VAL76B, VAL76C, VAL90B