3RJ1

architecture of the mediator head module

• Total interactions analyzed: 210
• Total true interactions: 49
• Strongest Interaction:
  • Chains: S-T
  • Int. Res.: 113
  • Norm. En. per Res.: -1.1469
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	0.0	-36.8999	-36.8999	80	11	9	2961	0	38	30
A-C	0.0	0.0	-4.8096	-4.8096	28	0	1	558	0	16	11
A-D	0.0	0.0	-5.1963	-5.1963	68	0	3	997	0	34	36
A-E	0.0	0.0	-0.0147	-0.0147	6	0	0	15	0	1	1
A-H	0.0	0.0	-17.8138	-17.8138	16	12	0	817	0	4	6
A-J	0.0	0.0	-0.0262	-0.0262	8	0	0	19	0	7	8
B-C	0.0	0.0	-42.4871	-42.4871	97	4	5	2756	0	43	32
B-D	0.0	0.0	-22.1567	-22.1567	73	1	8	1780	0	21	22
B-E	0.0	0.0	-21.296	-21.296	34	3	0	987	0	4	12
B-F	0.0	0.0	-0.196	-0.196	7	0	0	53	0	0	0
B-G	0.0	0.0	-22.8975	-22.8975	36	6	4	1784	0	17	10
C-D	0.0	0.0	-6.5514	-6.5514	44	0	0	756	0	8	6
C-E	0.0	0.0	-29.4782	-29.4782	44	12	0	1968	0	16	14
C-G	-9.2914	0.0	-36.259	-45.5504	52	15	7	2549	0	10	9
C-H	0.0	0.0	-0.0751	-0.0751	8	0	0	27	0	8	8
D-E	0.0	0.0	-0.0233	-0.0233	3	0	0	10	0	0	0
D-G	0.0	0.0	-1.2111	-1.2111	18	0	0	209	0	2	0
E-F	-22.8268	0.0	-106.759	-129.5858	114	23	14	5819	0	11	12
H-I	0.0	0.0	-36.9754	-36.9754	80	11	9	2961	0	38	30
H-J	0.0	0.0	-4.8094	-4.8094	28	0	1	558	0	16	11
H-K	0.0	0.0	-5.1817	-5.1817	68	0	3	995	0	34	36
H-L	0.0	0.0	-0.0147	-0.0147	6	0	0	15	0	1	1
I-J	0.0	0.0	-42.468	-42.468	97	4	5	2754	0	43	32
I-K	0.0	0.0	-22.1531	-22.1531	73	1	8	1779	0	21	23
I-L	0.0	0.0	-21.2975	-21.2975	34	3	0	987	0	4	12
I-M	0.0	0.0	-0.196	-0.196	7	0	0	53	0	0	0
I-N	0.0	0.0	-22.8464	-22.8464	36	6	4	1782	0	17	10
I-P	0.0	0.0	-0.0141	-0.0141	7	0	0	14	0	16	19
J-K	0.0	0.0	-6.5654	-6.5654	44	0	0	756	0	8	6
J-L	0.0	0.0	-29.523	-29.523	44	12	0	1969	0	16	14
J-N	-9.2792	0.0	-36.2542	-45.5334	52	15	7	2548	0	10	9
K-L	0.0	0.0	-0.0233	-0.0233	3	0	0	10	0	0	0
K-N	0.0	0.0	-1.2111	-1.2111	18	0	0	209	0	2	0
L-M	-22.8246	0.0	-106.682	-129.5066	114	23	14	5815	0	11	12
O-P	0.0	0.0	-37.0159	-37.0159	80	11	9	2960	0	38	30
O-Q	0.0	0.0	-4.8103	-4.8103	28	0	1	558	0	16	11
O-R	0.0	0.0	-5.181	-5.181	68	0	3	995	0	34	36
O-S	0.0	0.0	-0.0147	-0.0147	6	0	0	15	0	1	1
P-Q	0.0	0.0	-42.4798	-42.4798	97	4	5	2756	0	43	32
P-R	0.0	0.0	-22.1587	-22.1587	73	1	8	1780	0	21	23
P-S	0.0	0.0	-21.2886	-21.2886	34	3	0	987	0	4	12
P-T	0.0	0.0	-0.196	-0.196	7	0	0	53	0	0	0
P-U	0.0	0.0	-22.8448	-22.8448	36	6	4	1783	0	17	10
Q-R	0.0	0.0	-6.5652	-6.5652	44	0	0	756	0	8	6
Q-S	0.0	0.0	-29.4971	-29.4971	44	12	0	1969	0	16	14
Q-U	-9.2807	0.0	-36.1882	-45.4689	52	15	7	2548	0	10	9
R-S	0.0	0.0	-0.0233	-0.0233	3	0	0	10	0	0	0
R-U	0.0	0.0	-1.2107	-1.2107	18	0	0	209	0	2	0
S-T	-22.8131	0.0	-106.79	-129.6031	113	23	14	5814	0	11	12

Interface residues

• A-B: ALA123A, ALA293B, ARG292B, ARG509B, ARG523B, ARG74A, ASN285B, ASN296B, ASN304B, ASN310B, ASN502B, ASN66A, ASN92A, ASP289B, ASP307B, ASP76A, GLN109A, GLN117A, GLN303B, GLN314B, GLN63A, GLN70A, GLN81A, GLU116A, GLU286B, GLU65A, GLU73A, GLU85A, HIS306B, HIS67A, ILE124A, ILE301B, ILE435B, LEU120A, LEU121A, LEU125A, LEU290B, LEU291B, LEU298B, LEU302B, LEU431B, LEU432B, LEU503B, LEU510B, LEU512B, LEU520B, LEU75A, LEU82A, LYS113A, LYS288B, LYS297B, LYS499B, LYS517B, LYS61A, LYS69A, LYS77A, PHE295B, PHE516B, PHE64A, PHE71A, PRO127A, PRO62A, SER128A, SER287B, SER294B, SER299B, SER300B, SER315B, SER78A, THR111A, THR519B, THR79A, TRP309B, TYR72A, VAL506B, VAL513B, VAL514B, VAL60A, VAL68A, VAL93A
• A-C: ALA159C, ARG153C, ASN57A, ASP152C, ASP171C, CYS37A, GLN35A, GLN41A, GLN45A, GLU166C, GLU42A, GLU58A, HIS170C, ILE155C, ILE49A, LEU53A, LYS169C, LYS61A, PHE163C, PHE50A, PRO62A, SER38A, THR156C, THR162C, THR34A, TRP158C, TYR167C, VAL46A
• A-D: ALA117D, ALA22D, ALA43A, ALA5D, ARG25A, ARG77D, ARG83A, ASN110D, ASN26D, ASN68D, ASP100D, ASP76A, GLN12D, GLN35A, GLN4D, GLU101D, GLU106D, GLU113D, GLU115A, GLU11D, GLU33A, GLU42A, GLU65A, GLU73A, GLU8D, ILE124A, ILE25D, ILE32A, ILE79D, ILE86A, LEU107D, LEU118A, LEU121A, LEU125A, LEU26A, LEU29A, LEU36A, LEU40A, LEU65D, LEU72D, LEU73D, LEU75A, LEU75D, LEU82A, LEU89A, LYS69A, LYS80D, LYS82D, PHE99D, PRO127A, SER128A, SER18D, SER28A, SER78A, THR114D, THR15D, THR28D, THR62D, THR76D, THR79A, THR80A, TRP83D, TYR72A, TYR7D, VAL46A, VAL68A, VAL69D, VAL93A
• A-E: ASP110A, GLN109A, GLY15E, GLY28E, LEU18E, TYR21A
• A-H: ARG55A, ARG55H, ASN57A, ASN57H, GLU58A, GLU58H, GLY56A, GLY56H, LEU53A, LEU53H, LYS54A, LYS54H, SER59A, SER59H, VAL60A, VAL60H
• A-J: ARG55A, ASP152J, GLU52A, GLY51A, LEU148J, LYS141J, THR136J, VAL135J
• B-C: ALA138C, ALA214B, ALA221B, ALA35C, ALA41C, ALA57C, ARG115C, ARG130C, ARG153C, ARG204B, ARG205B, ARG37C, ARG48C, ARG51C, ASN212B, ASN216B, ASN285B, ASP34C, ASP91C, GLN150C, GLN282B, GLN31C, GLU131C, GLU143C, GLU146C, GLU217B, GLU223B, GLU234B, GLU268B, GLU286B, GLU58C, GLU88C, GLY134C, GLY237B, GLY278B, GLY30C, HIS45C, ILE211B, ILE274B, ILE50C, LEU113C, LEU114C, LEU149C, LEU208B, LEU220B, LEU222B, LEU227B, LEU228B, LEU229B, LEU275B, LEU281B, LEU33C, LEU40C, LEU43C, LEU47C, LEU90C, LYS100C, LYS117C, LYS233B, LYS266B, LYS267B, LYS277B, PHE101C, PHE224B, PRO99C, SER133C, SER218B, SER219B, SER226B, SER230B, SER231B, SER235B, SER240B, SER283B, SER46C, SER55C, SER92C, THR111C, THR132C, THR136C, THR137C, THR265B, THR44C, THR89C, THR93C, TRP279B, TYR128C, TYR269B, TYR96C, VAL110C, VAL129C, VAL201B, VAL225B, VAL232B, VAL36C, VAL94C, VAL95C
• B-D: ALA117D, ALA51D, ALA679B, ARG500B, ARG77D, ASN276B, ASN285B, ASN59D, ASP273B, CYS111D, GLN103D, GLN282B, GLN61D, GLU101D, GLU118D, GLU286B, GLU305B, GLU47D, GLU671B, HIS306B, HIS675B, ILE104D, ILE112D, ILE30D, ILE312B, ILE66D, ILE677B, LEU107D, LEU108D, LEU281B, LEU284B, LEU290B, LEU291B, LEU298B, LEU302B, LEU503B, LEU508B, LEU510B, LEU558B, LEU65D, LEU674B, LEU73D, LYS119D, LYS280B, LYS288B, LYS555B, LYS80D, PHE115D, PHE295B, PHE99D, SER283B, SER287B, SER294B, SER46D, SER54D, THR114D, THR28D, THR29D, THR52D, THR53D, THR62D, THR76D, TRP279B, TRP309B, TYR554B, TYR681B, VAL506B, VAL50D, VAL55D, VAL58D, VAL670B, VAL678B, VAL69D
• B-E: ARG523B, ASN29E, ASN86E, GLN683B, GLN684B, GLU231E, GLY227E, GLY28E, HIS226E, HIS528B, ILE229E, ILE524B, ILE682B, LEU228E, LEU230E, LEU32E, LEU33E, LEU85E, LYS221E, LYS225E, LYS685B, LYS686B, PHE222E, PHE223E, PHE72E, PHE87E, PRO30E, PRO31E, PRO527B, PRO84E, SER525B, SER526B, TYR256E, TYR34E
• B-F: GLY95F, HIS528B, PHE93F, PRO527B, PRO89F, SER525B, VAL92F
• B-G: ALA214B, ALA221B, ARG173G, ARG203B, ARG204B, ASN182G, ASN212B, ASN216B, ASP206B, GLN171G, GLU209B, GLU217B, GLU223B, HIS180G, HIS210B, ILE211B, LEU174G, LEU181G, LEU185G, LEU188G, LEU208B, LEU213B, LEU220B, LEU222B, LEU227B, PHE224B, SER176G, SER178G, SER183G, SER187G, SER218B, SER219B, THR177G, THR184G, TYR179G, VAL170G
• C-D: ALA22D, ALA49D, ALA51D, ARG153C, ARG160C, ASN157C, ASN26D, ASN59D, ASN60D, ASP171C, GLN64D, GLN68C, GLN70D, GLN75C, GLN84C, GLU154C, GLU23D, GLU47D, GLU88C, HIS85C, ILE30D, LEU48D, LYS67D, PHE163C, PHE86C, SER46D, SER74C, SER78C, SER81C, THR156C, THR28D, THR29D, THR52D, THR53D, THR64C, THR80C, THR82C, TYR167C, VAL129C, VAL19D, VAL50D, VAL71C, VAL77C, VAL79C
• C-E: ARG293E, ARG299E, ARG63E, ASN197C, ASN62E, ASP199C, ASP200C, ASP292E, ASP297E, GLN294E, GLU209C, GLU212E, GLY208C, GLY249E, GLY250E, GLY9E, ILE11E, ILE246E, LEU202C, LEU252E, LEU7E, LYS203C, PHE196C, PHE204C, PHE206C, PHE213E, PHE8E, PRO195C, PRO291E, PRO61E, SER10E, SER248E, SER289E, SER295E, SER298E, THR205C, THR207C, THR247E, TYR215E, VAL198C, VAL201C, VAL290E, VAL300E, VAL40E
• C-G: ARG115C, ARG173G, ASN118C, ASN182G, ASN70C, ASP123C, ASP91C, GLN171G, GLN84C, GLN87C, GLU121C, GLU88C, HIS180G, ILE119C, ILE166G, ILE169G, ILE50C, LEU113C, LEU114C, LEU174G, LEU181G, LEU185G, LEU188G, LEU33C, LEU47C, LEU90C, LYS116C, LYS117C, LYS168G, PHE167G, PRO120C, PRO97C, PRO99C, SER172G, SER176G, SER178G, SER67C, SER74C, SER78C, SER81C, SER92C, THR177G, THR93C, TRP125C, TYR179G, TYR96C, VAL122C, VAL170G, VAL71C, VAL77C, VAL94C, VAL95C
• C-H: ARG55H, ASP152C, GLU52H, GLY51H, ILE145C, LEU148C, LYS141C, THR136C
• D-E: ALA5D, GLN4D, GLY284E
• D-G: ARG173G, ASN182G, ASN59D, GLN171G, GLU186G, GLU47D, ILE169G, LEU174G, LEU185G, LEU48D, LYS168G, SER172G, SER176G, SER178G, THR52D, TYR179G, TYR189G, VAL55D
• E-F: ALA186E, ALA194E, ALA77F, ALA82F, ALA83F, ALA84F, ALA90F, ARG261E, ASN114F, ASN195F, ASN197E, ASN258E, ASN35E, ASN48F, ASN62E, ASN75F, ASN94F, ASP170E, ASP192F, ASP48E, ASP74F, ASP86F, CYS161E, CYS198F, CYS38E, CYS44F, GLN167E, GLN3E, GLN4E, GLN68F, GLU102F, GLU159E, GLU187E, GLU231E, GLU69E, GLY190F, GLY195E, GLY206E, GLY219E, GLY262E, GLY95F, GLY99F, ILE104F, ILE107F, ILE115F, ILE168E, ILE185E, ILE189E, ILE190E, ILE218E, ILE229E, ILE257E, ILE46F, ILE87F, LEU166E, LEU189F, LEU191E, LEU203E, LEU207E, LEU32E, LEU33E, LEU37E, LEU49F, LEU66E, LEU71F, LEU91F, LYS111F, LYS196E, LYS221E, LYS47F, LYS68E, LYS73F, PHE93F, PRO101F, PRO163E, PRO191F, PRO88F, SER103F, SER160E, SER162E, SER165E, SER192E, SER193E, SER194F, SER198E, SER199E, SER202E, SER260E, SER36E, SER45F, SER67E, SER76F, SER96F, SER97F, THR106F, THR184E, THR188E, THR193F, THR69F, THR80F, THR81F, THR98F, TRP164E, TYR256E, TYR34E, TYR47E, VAL100F, VAL259E, VAL2E, VAL49E, VAL70E, VAL70F, VAL79F, VAL92F
• H-I: ALA123H, ALA293I, ARG292I, ARG509I, ARG523I, ARG74H, ASN285I, ASN296I, ASN304I, ASN310I, ASN502I, ASN66H, ASN92H, ASP289I, ASP307I, ASP76H, GLN109H, GLN117H, GLN303I, GLN314I, GLN63H, GLN70H, GLN81H, GLU116H, GLU286I, GLU65H, GLU73H, GLU85H, HIS306I, HIS67H, ILE124H, ILE301I, ILE435I, LEU120H, LEU121H, LEU125H, LEU290I, LEU291I, LEU298I, LEU302I, LEU431I, LEU432I, LEU503I, LEU510I, LEU512I, LEU520I, LEU75H, LEU82H, LYS113H, LYS288I, LYS297I, LYS499I, LYS517I, LYS61H, LYS69H, LYS77H, PHE295I, PHE516I, PHE64H, PHE71H, PRO127H, PRO62H, SER128H, SER287I, SER294I, SER299I, SER300I, SER315I, SER78H, THR111H, THR519I, THR79H, TRP309I, TYR72H, VAL506I, VAL513I, VAL514I, VAL60H, VAL68H, VAL93H
• H-J: ALA159J, ARG153J, ASN57H, ASP152J, ASP171J, CYS37H, GLN35H, GLN41H, GLN45H, GLU166J, GLU42H, GLU58H, HIS170J, ILE155J, ILE49H, LEU53H, LYS169J, LYS61H, PHE163J, PHE50H, PRO62H, SER38H, THR156J, THR162J, THR34H, TRP158J, TYR167J, VAL46H
• H-K: ALA117K, ALA22K, ALA43H, ALA5K, ARG25H, ARG77K, ARG83H, ASN110K, ASN26K, ASN68K, ASP100K, ASP76H, GLN12K, GLN35H, GLN4K, GLU101K, GLU106K, GLU113K, GLU115H, GLU11K, GLU33H, GLU42H, GLU65H, GLU73H, GLU8K, ILE124H, ILE25K, ILE32H, ILE79K, ILE86H, LEU107K, LEU118H, LEU121H, LEU125H, LEU26H, LEU29H, LEU36H, LEU40H, LEU65K, LEU72K, LEU73K, LEU75H, LEU75K, LEU82H, LEU89H, LYS69H, LYS80K, LYS82K, PHE99K, PRO127H, SER128H, SER18K, SER28H, SER78H, THR114K, THR15K, THR28K, THR62K, THR76K, THR79H, THR80H, TRP83K, TYR72H, TYR7K, VAL46H, VAL68H, VAL69K, VAL93H
• H-L: ASP110H, GLN109H, GLY15L, GLY28L, LEU18L, TYR21H
• I-J: ALA138J, ALA214I, ALA221I, ALA35J, ALA41J, ALA57J, ARG115J, ARG130J, ARG153J, ARG204I, ARG205I, ARG37J, ARG48J, ARG51J, ASN212I, ASN216I, ASN285I, ASP34J, ASP91J, GLN150J, GLN282I, GLN31J, GLU131J, GLU143J, GLU146J, GLU217I, GLU223I, GLU234I, GLU268I, GLU286I, GLU58J, GLU88J, GLY134J, GLY237I, GLY278I, GLY30J, HIS45J, ILE211I, ILE274I, ILE50J, LEU113J, LEU114J, LEU149J, LEU208I, LEU220I, LEU222I, LEU227I, LEU228I, LEU229I, LEU275I, LEU281I, LEU33J, LEU40J, LEU43J, LEU47J, LEU90J, LYS100J, LYS117J, LYS233I, LYS266I, LYS267I, LYS277I, PHE101J, PHE224I, PRO99J, SER133J, SER218I, SER219I, SER226I, SER230I, SER231I, SER235I, SER240I, SER283I, SER46J, SER55J, SER92J, THR111J, THR132J, THR136J, THR137J, THR265I, THR44J, THR89J, THR93J, TRP279I, TYR128J, TYR269I, TYR96J, VAL110J, VAL129J, VAL201I, VAL225I, VAL232I, VAL36J, VAL94J, VAL95J
• I-K: ALA117K, ALA51K, ALA679I, ARG500I, ARG77K, ASN276I, ASN285I, ASN59K, ASP273I, CYS111K, GLN103K, GLN282I, GLN61K, GLU101K, GLU118K, GLU286I, GLU305I, GLU47K, GLU671I, HIS306I, HIS675I, ILE104K, ILE112K, ILE30K, ILE312I, ILE66K, ILE677I, LEU107K, LEU108K, LEU281I, LEU284I, LEU290I, LEU291I, LEU298I, LEU302I, LEU503I, LEU508I, LEU510I, LEU558I, LEU65K, LEU674I, LEU73K, LYS119K, LYS280I, LYS288I, LYS555I, LYS80K, PHE115K, PHE295I, PHE99K, SER283I, SER287I, SER294I, SER46K, SER54K, THR114K, THR28K, THR29K, THR52K, THR53K, THR62K, THR76K, TRP279I, TRP309I, TYR554I, TYR681I, VAL506I, VAL50K, VAL55K, VAL58K, VAL670I, VAL678I, VAL69K
• I-L: ARG523I, ASN29L, ASN86L, GLN683I, GLN684I, GLU231L, GLY227L, GLY28L, HIS226L, HIS528I, ILE229L, ILE524I, ILE682I, LEU228L, LEU230L, LEU32L, LEU33L, LEU85L, LYS221L, LYS225L, LYS685I, LYS686I, PHE222L, PHE223L, PHE72L, PHE87L, PRO30L, PRO31L, PRO527I, PRO84L, SER525I, SER526I, TYR256L, TYR34L
• I-M: GLY95M, HIS528I, PHE93M, PRO527I, PRO89M, SER525I, VAL92M
• I-N: ALA214I, ALA221I, ARG173N, ARG203I, ARG204I, ASN182N, ASN212I, ASN216I, ASP206I, GLN171N, GLU209I, GLU217I, GLU223I, HIS180N, HIS210I, ILE211I, LEU174N, LEU181N, LEU185N, LEU188N, LEU208I, LEU213I, LEU220I, LEU222I, LEU227I, PHE224I, SER176N, SER178N, SER183N, SER187N, SER218I, SER219I, THR177N, THR184N, TYR179N, VAL170N
• I-P: ARG205I, ARG205P, GLU209I, HIS489I, HIS489P, LYS202I, SER485P
• J-K: ALA22K, ALA49K, ALA51K, ARG153J, ARG160J, ASN157J, ASN26K, ASN59K, ASN60K, ASP171J, GLN64K, GLN68J, GLN70K, GLN75J, GLN84J, GLU154J, GLU23K, GLU47K, GLU88J, HIS85J, ILE30K, LEU48K, LYS67K, PHE163J, PHE86J, SER46K, SER74J, SER78J, SER81J, THR156J, THR28K, THR29K, THR52K, THR53K, THR64J, THR80J, THR82J, TYR167J, VAL129J, VAL19K, VAL50K, VAL71J, VAL77J, VAL79J
• J-L: ARG293L, ARG299L, ARG63L, ASN197J, ASN62L, ASP199J, ASP200J, ASP292L, ASP297L, GLN294L, GLU209J, GLU212L, GLY208J, GLY249L, GLY250L, GLY9L, ILE11L, ILE246L, LEU202J, LEU252L, LEU7L, LYS203J, PHE196J, PHE204J, PHE206J, PHE213L, PHE8L, PRO195J, PRO291L, PRO61L, SER10L, SER248L, SER289L, SER295L, SER298L, THR205J, THR207J, THR247L, TYR215L, VAL198J, VAL201J, VAL290L, VAL300L, VAL40L
• J-N: ARG115J, ARG173N, ASN118J, ASN182N, ASN70J, ASP123J, ASP91J, GLN171N, GLN84J, GLN87J, GLU121J, GLU88J, HIS180N, ILE119J, ILE166N, ILE169N, ILE50J, LEU113J, LEU114J, LEU174N, LEU181N, LEU185N, LEU188N, LEU33J, LEU47J, LEU90J, LYS116J, LYS117J, LYS168N, PHE167N, PRO120J, PRO97J, PRO99J, SER172N, SER176N, SER178N, SER67J, SER74J, SER78J, SER81J, SER92J, THR177N, THR93J, TRP125J, TYR179N, TYR96J, VAL122J, VAL170N, VAL71J, VAL77J, VAL94J, VAL95J
• K-L: ALA5K, GLN4K, GLY284L
• K-N: ARG173N, ASN182N, ASN59K, GLN171N, GLU186N, GLU47K, ILE169N, LEU174N, LEU185N, LEU48K, LYS168N, SER172N, SER176N, SER178N, THR52K, TYR179N, TYR189N, VAL55K
• L-M: ALA186L, ALA194L, ALA77M, ALA82M, ALA83M, ALA84M, ALA90M, ARG261L, ASN114M, ASN195M, ASN197L, ASN258L, ASN35L, ASN48M, ASN62L, ASN75M, ASN94M, ASP170L, ASP192M, ASP48L, ASP74M, ASP86M, CYS161L, CYS198M, CYS38L, CYS44M, GLN167L, GLN3L, GLN4L, GLN68M, GLU102M, GLU159L, GLU187L, GLU231L, GLU69L, GLY190M, GLY195L, GLY206L, GLY219L, GLY262L, GLY95M, GLY99M, ILE104M, ILE107M, ILE115M, ILE168L, ILE185L, ILE189L, ILE190L, ILE218L, ILE229L, ILE257L, ILE46M, ILE87M, LEU166L, LEU189M, LEU191L, LEU203L, LEU207L, LEU32L, LEU33L, LEU37L, LEU49M, LEU66L, LEU71M, LEU91M, LYS111M, LYS196L, LYS221L, LYS47M, LYS68L, LYS73M, PHE93M, PRO101M, PRO163L, PRO191M, PRO88M, SER103M, SER160L, SER162L, SER165L, SER192L, SER193L, SER194M, SER198L, SER199L, SER202L, SER260L, SER36L, SER45M, SER67L, SER76M, SER96M, SER97M, THR106M, THR184L, THR188L, THR193M, THR69M, THR80M, THR81M, THR98M, TRP164L, TYR256L, TYR34L, TYR47L, VAL100M, VAL259L, VAL2L, VAL49L, VAL70L, VAL70M, VAL79M, VAL92M
• O-P: ALA123O, ALA293P, ARG292P, ARG509P, ARG523P, ARG74O, ASN285P, ASN296P, ASN304P, ASN310P, ASN502P, ASN66O, ASN92O, ASP289P, ASP307P, ASP76O, GLN109O, GLN117O, GLN303P, GLN314P, GLN63O, GLN70O, GLN81O, GLU116O, GLU286P, GLU65O, GLU73O, GLU85O, HIS306P, HIS67O, ILE124O, ILE301P, ILE435P, LEU120O, LEU121O, LEU125O, LEU290P, LEU291P, LEU298P, LEU302P, LEU431P, LEU432P, LEU503P, LEU510P, LEU512P, LEU520P, LEU75O, LEU82O, LYS113O, LYS288P, LYS297P, LYS499P, LYS517P, LYS61O, LYS69O, LYS77O, PHE295P, PHE516P, PHE64O, PHE71O, PRO127O, PRO62O, SER128O, SER287P, SER294P, SER299P, SER300P, SER315P, SER78O, THR111O, THR519P, THR79O, TRP309P, TYR72O, VAL506P, VAL513P, VAL514P, VAL60O, VAL68O, VAL93O
• O-Q: ALA159Q, ARG153Q, ASN57O, ASP152Q, ASP171Q, CYS37O, GLN35O, GLN41O, GLN45O, GLU166Q, GLU42O, GLU58O, HIS170Q, ILE155Q, ILE49O, LEU53O, LYS169Q, LYS61O, PHE163Q, PHE50O, PRO62O, SER38O, THR156Q, THR162Q, THR34O, TRP158Q, TYR167Q, VAL46O
• O-R: ALA117R, ALA22R, ALA43O, ALA5R, ARG25O, ARG77R, ARG83O, ASN110R, ASN26R, ASN68R, ASP100R, ASP76O, GLN12R, GLN35O, GLN4R, GLU101R, GLU106R, GLU113R, GLU115O, GLU11R, GLU33O, GLU42O, GLU65O, GLU73O, GLU8R, ILE124O, ILE25R, ILE32O, ILE79R, ILE86O, LEU107R, LEU118O, LEU121O, LEU125O, LEU26O, LEU29O, LEU36O, LEU40O, LEU65R, LEU72R, LEU73R, LEU75O, LEU75R, LEU82O, LEU89O, LYS69O, LYS80R, LYS82R, PHE99R, PRO127O, SER128O, SER18R, SER28O, SER78O, THR114R, THR15R, THR28R, THR62R, THR76R, THR79O, THR80O, TRP83R, TYR72O, TYR7R, VAL46O, VAL68O, VAL69R, VAL93O
• O-S: ASP110O, GLN109O, GLY15S, GLY28S, LEU18S, TYR21O
• P-Q: ALA138Q, ALA214P, ALA221P, ALA35Q, ALA41Q, ALA57Q, ARG115Q, ARG130Q, ARG153Q, ARG204P, ARG205P, ARG37Q, ARG48Q, ARG51Q, ASN212P, ASN216P, ASN285P, ASP34Q, ASP91Q, GLN150Q, GLN282P, GLN31Q, GLU131Q, GLU143Q, GLU146Q, GLU217P, GLU223P, GLU234P, GLU268P, GLU286P, GLU58Q, GLU88Q, GLY134Q, GLY237P, GLY278P, GLY30Q, HIS45Q, ILE211P, ILE274P, ILE50Q, LEU113Q, LEU114Q, LEU149Q, LEU208P, LEU220P, LEU222P, LEU227P, LEU228P, LEU229P, LEU275P, LEU281P, LEU33Q, LEU40Q, LEU43Q, LEU47Q, LEU90Q, LYS100Q, LYS117Q, LYS233P, LYS266P, LYS267P, LYS277P, PHE101Q, PHE224P, PRO99Q, SER133Q, SER218P, SER219P, SER226P, SER230P, SER231P, SER235P, SER240P, SER283P, SER46Q, SER55Q, SER92Q, THR111Q, THR132Q, THR136Q, THR137Q, THR265P, THR44Q, THR89Q, THR93Q, TRP279P, TYR128Q, TYR269P, TYR96Q, VAL110Q, VAL129Q, VAL201P, VAL225P, VAL232P, VAL36Q, VAL94Q, VAL95Q
• P-R: ALA117R, ALA51R, ALA679P, ARG500P, ARG77R, ASN276P, ASN285P, ASN59R, ASP273P, CYS111R, GLN103R, GLN282P, GLN61R, GLU101R, GLU118R, GLU286P, GLU305P, GLU47R, GLU671P, HIS306P, HIS675P, ILE104R, ILE112R, ILE30R, ILE312P, ILE66R, ILE677P, LEU107R, LEU108R, LEU281P, LEU284P, LEU290P, LEU291P, LEU298P, LEU302P, LEU503P, LEU508P, LEU510P, LEU558P, LEU65R, LEU674P, LEU73R, LYS119R, LYS280P, LYS288P, LYS555P, LYS80R, PHE115R, PHE295P, PHE99R, SER283P, SER287P, SER294P, SER46R, SER54R, THR114R, THR28R, THR29R, THR52R, THR53R, THR62R, THR76R, TRP279P, TRP309P, TYR554P, TYR681P, VAL506P, VAL50R, VAL55R, VAL58R, VAL670P, VAL678P, VAL69R
• P-S: ARG523P, ASN29S, ASN86S, GLN683P, GLN684P, GLU231S, GLY227S, GLY28S, HIS226S, HIS528P, ILE229S, ILE524P, ILE682P, LEU228S, LEU230S, LEU32S, LEU33S, LEU85S, LYS221S, LYS225S, LYS685P, LYS686P, PHE222S, PHE223S, PHE72S, PHE87S, PRO30S, PRO31S, PRO527P, PRO84S, SER525P, SER526P, TYR256S, TYR34S
• P-T: GLY95T, HIS528P, PHE93T, PRO527P, PRO89T, SER525P, VAL92T
• P-U: ALA214P, ALA221P, ARG173U, ARG203P, ARG204P, ASN182U, ASN212P, ASN216P, ASP206P, GLN171U, GLU209P, GLU217P, GLU223P, HIS180U, HIS210P, ILE211P, LEU174U, LEU181U, LEU185U, LEU188U, LEU208P, LEU213P, LEU220P, LEU222P, LEU227P, PHE224P, SER176U, SER178U, SER183U, SER187U, SER218P, SER219P, THR177U, THR184U, TYR179U, VAL170U
• Q-R: ALA22R, ALA49R, ALA51R, ARG153Q, ARG160Q, ASN157Q, ASN26R, ASN59R, ASN60R, ASP171Q, GLN64R, GLN68Q, GLN70R, GLN75Q, GLN84Q, GLU154Q, GLU23R, GLU47R, GLU88Q, HIS85Q, ILE30R, LEU48R, LYS67R, PHE163Q, PHE86Q, SER46R, SER74Q, SER78Q, SER81Q, THR156Q, THR28R, THR29R, THR52R, THR53R, THR64Q, THR80Q, THR82Q, TYR167Q, VAL129Q, VAL19R, VAL50R, VAL71Q, VAL77Q, VAL79Q
• Q-S: ARG293S, ARG299S, ARG63S, ASN197Q, ASN62S, ASP199Q, ASP200Q, ASP292S, ASP297S, GLN294S, GLU209Q, GLU212S, GLY208Q, GLY249S, GLY250S, GLY9S, ILE11S, ILE246S, LEU202Q, LEU252S, LEU7S, LYS203Q, PHE196Q, PHE204Q, PHE206Q, PHE213S, PHE8S, PRO195Q, PRO291S, PRO61S, SER10S, SER248S, SER289S, SER295S, SER298S, THR205Q, THR207Q, THR247S, TYR215S, VAL198Q, VAL201Q, VAL290S, VAL300S, VAL40S
• Q-U: ARG115Q, ARG173U, ASN118Q, ASN182U, ASN70Q, ASP123Q, ASP91Q, GLN171U, GLN84Q, GLN87Q, GLU121Q, GLU88Q, HIS180U, ILE119Q, ILE166U, ILE169U, ILE50Q, LEU113Q, LEU114Q, LEU174U, LEU181U, LEU185U, LEU188U, LEU33Q, LEU47Q, LEU90Q, LYS116Q, LYS117Q, LYS168U, PHE167U, PRO120Q, PRO97Q, PRO99Q, SER172U, SER176U, SER178U, SER67Q, SER74Q, SER78Q, SER81Q, SER92Q, THR177U, THR93Q, TRP125Q, TYR179U, TYR96Q, VAL122Q, VAL170U, VAL71Q, VAL77Q, VAL94Q, VAL95Q
• R-S: ALA5R, GLN4R, GLY284S
• R-U: ARG173U, ASN182U, ASN59R, GLN171U, GLU186U, GLU47R, ILE169U, LEU174U, LEU185U, LEU48R, LYS168U, SER172U, SER176U, SER178U, THR52R, TYR179U, TYR189U, VAL55R
• S-T: ALA186S, ALA194S, ALA77T, ALA82T, ALA83T, ALA84T, ALA90T, ARG261S, ASN114T, ASN195T, ASN197S, ASN258S, ASN35S, ASN48T, ASN62S, ASN75T, ASN94T, ASP170S, ASP192T, ASP48S, ASP74T, ASP86T, CYS161S, CYS198T, CYS38S, CYS44T, GLN167S, GLN3S, GLN4S, GLN68T, GLU102T, GLU159S, GLU187S, GLU231S, GLU69S, GLY190T, GLY195S, GLY206S, GLY219S, GLY262S, GLY95T, GLY99T, ILE104T, ILE107T, ILE115T, ILE168S, ILE185S, ILE189S, ILE190S, ILE218S, ILE229S, ILE257S, ILE46T, ILE87T, LEU166S, LEU189T, LEU191S, LEU203S, LEU207S, LEU32S, LEU33S, LEU37S, LEU49T, LEU66S, LEU71T, LEU91T, LYS111T, LYS196S, LYS221S, LYS47T, LYS68S, LYS73T, PHE93T, PRO101T, PRO163S, PRO191T, PRO88T, SER103T, SER160S, SER162S, SER165S, SER192S, SER193S, SER194T, SER198S, SER199S, SER202S, SER260S, SER36S, SER45T, SER67S, SER76T, SER96T, SER97T, THR106T, THR184S, THR188S, THR193T, THR69T, THR80T, THR81T, THR98T, TRP164S, TYR34S, TYR47S, VAL100T, VAL259S, VAL2S, VAL49S, VAL70S, VAL70T, VAL79T, VAL92T