3RIA

c. elegans glutamate-gated chloride channel (glucl) in complex with fab, ivermectin and iodide.

• Total interactions analyzed: 105
• Total true interactions: 30
• Strongest Interaction:
  • Chains: I-O
  • Int. Res.: 182
  • Norm. En. per Res.: -3.23
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-23.9974	-24.9523	-470.228	-519.1777	243	36	19	22374	5	37	34
A-C	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	0
A-D	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	0
A-E	-29.4601	-25.1519	-459.41	-514.022	238	28	19	21860	5	37	33
A-H	-17.7316	11.8503	-92.4194	-98.3007	48	10	3	4237	3	3	4
A-J	-10.4946	-5.1684	-21.5896	-37.2526	30	1	2	888	0	7	4
A-L	0.0	0.0	-55.4279	-55.4279	47	2	2	3101	0	2	2
B-C	-23.7613	-27.2804	-471.116	-522.1577	248	56	19	23254	6	38	34
B-D	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	0
B-E	0.0	0.0	-0.0007	-0.0007	2	0	0	2	0	0	0
B-F	-23.4061	13.0337	-88.0264	-98.3989	48	19	3	4524	3	3	4
B-H	-5.8048	-4.5653	-23.2389	-33.609	30	1	2	906	0	6	4
B-N	0.0	0.0	-68.8925	-68.8925	48	4	2	3415	0	2	2
C-D	-27.9383	-27.9098	-476.844	-532.6922	244	40	20	22667	5	38	33
C-E	0.0	0.0	-0.0004	-0.0004	2	0	0	1	0	0	0
C-F	0.0	-4.429	-19.1625	-23.5915	28	0	2	815	0	6	4
C-G	-20.6135	12.2806	-92.9015	-101.2344	48	11	3	4357	3	3	4
C-K	0.0	0.0	-55.6042	-55.6042	46	2	2	3149	0	2	2
D-E	-22.3486	-23.8129	-462.224	-508.3855	239	42	20	22281	5	37	34
D-G	0.0	-4.3653	-25.6397	-30.005	30	1	2	956	0	8	4
D-I	-20.5583	13.74	-95.8914	-102.7097	49	8	3	4230	3	3	4
D-O	0.0	0.0	-55.4832	-55.4832	49	0	2	3115	0	2	2
E-I	-11.2292	-4.0908	-21.1641	-36.4841	28	1	2	830	0	6	4
E-J	-21.6176	11.9439	-94.0463	-103.7199	50	20	3	4507	3	3	5
E-M	0.0	0.0	-64.705	-64.705	47	1	2	3344	0	2	2
F-N	-28.495	-8.9371	-370.611	-408.0431	153	19	10	15162	0	12	13
G-K	-40.5266	-22.1761	-452.543	-515.2458	174	27	12	19047	1	19	17
H-L	-46.6815	-26.8081	-492.828	-566.3176	193	22	13	19481	2	18	17
I-O	-50.8749	-40.5377	-496.447	-587.8596	182	41	14	20578	2	19	17
J-M	-21.7014	-31.3054	-500.103	-553.1098	189	25	13	19836	2	18	17

Interface residues

• A-B: ALA149A, ALA152A, ALA241A, ALA241B, ALA244A, ALA244B, ALA258A, ALA258B, ALA261A, ALA290A, ALA295A, ALA51B, ALA7B, ALA98A, ARG111B, ARG123A, ARG123B, ARG17A, ARG19A, ARG204A, ARG211B, ARG239B, ARG245A, ARG245B, ARG320B, ARG37B, ARG56B, ARG63A, ASN107B, ASN196A, ASN264A, ASN298A, ASN302A, ASN33B, ASN46A, ASN94A, ASP104B, ASP147A, ASP157A, ASP15A, ASP238B, ASP277A, ASP2B, ASP316B, ASP43A, ASP75B, ASP89A, CYS130A, CYS202A, CYS225B, CYS283A, CYS289A, GLN169B, GLN182B, GLN219B, GLN259B, GLN266A, GLN266B, GLN52B, GLN84A, GLN97A, GLU212B, GLU293A, GLU48A, GLU57A, GLU95A, GLY173B, GLY198A, GLY249A, GLY249B, GLY262B, GLY281A, GLY82B, HIS101A, HIS101B, HIS113B, HIS165B, HIS299A, HIS83B, ILE103B, ILE110B, ILE124A, ILE124B, ILE199A, ILE222B, ILE229B, ILE242A, ILE242B, ILE263A, ILE273A, ILE276A, ILE280A, ILE287A, ILE300A, ILE39B, ILE42B, ILE78B, LEU109B, LEU119B, LEU126A, LEU128A, LEU134A, LEU148A, LEU174B, LEU178B, LEU217B, LEU218B, LEU227B, LEU248A, LEU248B, LEU253A, LEU254A, LEU254B, LEU267A, LEU291A, LEU292A, LEU296A, LEU317B, LEU35B, LEU53A, LEU53B, LEU55A, LEU55B, LEU6B, LEU79B, LYS100A, LYS100B, LYS105B, LYS156A, LYS163B, LYS171B, LYS274A, LYS41B, LYS4B, LYS96A, MET132A, MET226B, MET256A, MET256B, MET284A, MET47A, MET87A, PHE10B, PHE16A, PHE181B, PHE213B, PHE215B, PHE235B, PHE237B, PHE288A, PHE294A, PHE76B, PHE91A, PHE92A, PRO106B, PRO131A, PRO179B, PRO223B, PRO243A, PRO243B, PRO268A, PRO269A, PRO74B, PRO88A, PRO93A, SER121B, SER125A, SER125B, SER129A, SER150A, SER166B, SER175B, SER176B, SER177B, SER180B, SER193A, SER1B, SER214B, SER231B, SER234B, SER260A, SER265A, SER271A, SER3B, SER40B, SER50B, THR102B, THR154A, THR155A, THR195A, THR197A, THR240A, THR240B, THR247A, THR247B, THR251A, THR251B, THR252A, THR252B, THR255A, THR255B, THR257A, THR285A, THR38B, THR54B, THR80B, THR90A, TRP232B, TRP236B, TRP86A, TYR120A, TYR120B, TYR133A, TYR137B, TYR151A, TYR153A, TYR160A, TYR200A, TYR216B, TYR272A, TYR99A, TYR99B, VAL108A, VAL108B, VAL122A, VAL122B, VAL127A, VAL172B, VAL18A, VAL228B, VAL230B, VAL233B, VAL246A, VAL246B, VAL250A, VAL250B, VAL270A, VAL278A, VAL297A, VAL44A, VAL45A, VAL77B, VAL81B
• A-C: PRO243A, PRO243C
• A-D: PRO243A, PRO243D
• A-E: ALA149E, ALA152E, ALA241A, ALA244A, ALA244E, ALA258A, ALA258E, ALA261E, ALA295E, ALA51A, ALA7A, ALA98E, ARG111A, ARG123A, ARG123E, ARG17E, ARG19E, ARG204E, ARG211A, ARG239A, ARG245A, ARG245E, ARG320A, ARG37A, ARG56A, ARG63E, ASN107A, ASN196E, ASN264E, ASN298E, ASN302E, ASN33A, ASN46E, ASN94E, ASP104A, ASP147E, ASP157E, ASP15E, ASP238A, ASP277E, ASP2A, ASP316A, ASP43E, ASP75A, ASP89E, CYS130E, CYS225A, CYS289E, GLN169A, GLN182A, GLN219A, GLN259A, GLN266A, GLN266E, GLN52A, GLN84E, GLN97E, GLU212A, GLU293E, GLU48E, GLU57E, GLU95E, GLY173A, GLY198E, GLY249A, GLY249E, GLY262A, GLY281E, GLY82A, HIS101A, HIS101E, HIS113A, HIS165A, HIS299E, HIS83A, ILE103A, ILE110A, ILE124A, ILE124E, ILE199E, ILE222A, ILE229A, ILE242A, ILE242E, ILE263E, ILE273E, ILE276E, ILE280E, ILE287E, ILE300E, ILE39A, ILE42A, ILE78A, LEU109A, LEU119A, LEU126E, LEU128E, LEU134E, LEU148E, LEU174A, LEU178A, LEU217A, LEU218A, LEU227A, LEU248A, LEU248E, LEU253E, LEU254A, LEU254E, LEU267E, LEU291E, LEU292E, LEU296E, LEU317A, LEU35A, LEU53A, LEU53E, LEU55A, LEU55E, LEU6A, LEU79A, LYS100A, LYS100E, LYS105A, LYS156E, LYS163A, LYS171A, LYS274E, LYS41A, LYS4A, LYS96E, MET132E, MET226A, MET256A, MET256E, MET284E, MET47E, MET87E, PHE10A, PHE16E, PHE181A, PHE213A, PHE215A, PHE235A, PHE237A, PHE288E, PHE294E, PHE76A, PHE91E, PHE92E, PRO106A, PRO131E, PRO179A, PRO223A, PRO243A, PRO243E, PRO268E, PRO269E, PRO74A, PRO88E, PRO93E, SER121A, SER125A, SER125E, SER129E, SER150E, SER166A, SER175A, SER176A, SER177A, SER180A, SER193E, SER1A, SER214A, SER231A, SER234A, SER260E, SER265E, SER271E, SER3A, SER40A, SER50A, THR102A, THR154E, THR155E, THR195E, THR197E, THR240A, THR240E, THR247A, THR247E, THR251A, THR251E, THR252A, THR255A, THR255E, THR257E, THR285E, THR38A, THR54A, THR80A, THR90E, TRP232A, TRP236A, TRP86E, TYR120A, TYR120E, TYR133E, TYR137A, TYR151E, TYR153E, TYR160E, TYR200E, TYR216A, TYR272E, TYR99A, TYR99E, VAL108A, VAL108E, VAL122A, VAL122E, VAL127E, VAL172A, VAL18E, VAL228A, VAL230A, VAL233A, VAL246A, VAL246E, VAL250A, VAL250E, VAL270E, VAL278E, VAL297E, VAL44E, VAL45E, VAL77A, VAL81A
• A-H: ARG104H, ARG107H, ARG204A, ASN196A, ASN52H, ASN55H, ASP101H, ASP99H, CYS191A, CYS202A, GLN62H, GLU159A, GLY106H, GLY198A, GLY49H, GLY56H, GLY57H, ILE158A, ILE199A, ILE51H, LEU161A, LEU50H, LYS156A, MET34H, PRO27A, PRO53H, SER193A, SER201A, SER59H, THR154A, THR155A, THR189A, THR192A, THR195A, THR197A, THR33H, THR58H, TRP47H, TYR102H, TYR103H, TYR105H, TYR160A, TYR190A, TYR200A, TYR32H, TYR54H, TYR60H, VAL194A
• A-J: ARG104J, ARG56A, ASN55J, ASP71A, ASP75A, GLN169A, GLN62J, GLN73A, GLY173A, GLY31J, GLY56J, GLY57J, HIS113A, HIS165A, LEU170A, LEU174A, LEU35A, LEU36A, LYS171A, LYS65J, LYS74J, PHE76A, PRO74A, SER166A, SER175A, THR30J, TYR102J, TYR103J, TYR54J, VAL172A
• A-L: ALA28L, ALA2L, ARG19A, ASN24A, ASN33L, ASN54L, ASN55L, ASN96L, ASP157A, ASP23A, GLN1L, GLU159A, GLU164A, GLY25A, GLY26A, GLY27L, HIS97L, ILE158A, ILE199A, ILE32L, ILE53L, LEU161A, LEU203A, LYS156A, PHE34L, PRO27A, SER201A, SER24L, SER95L, THR154A, THR155A, THR189A, THR192A, THR22A, THR26L, THR30L, THR31L, TRP162A, TRP93L, TYR160A, TYR190A, TYR94L, VAL194A, VAL28A, VAL29A, VAL29L, VAL30A
• B-C: ALA149B, ALA152B, ALA241B, ALA241C, ALA244B, ALA244C, ALA258B, ALA258C, ALA261B, ALA290B, ALA295B, ALA301B, ALA303B, ALA51C, ALA7C, ALA98B, ARG111C, ARG123B, ARG123C, ARG17B, ARG19B, ARG204B, ARG211C, ARG239C, ARG245B, ARG245C, ARG320C, ARG37C, ARG56C, ARG63B, ASN107C, ASN196B, ASN264B, ASN298B, ASN302B, ASN33C, ASN46B, ASN94B, ASP104C, ASP147B, ASP157B, ASP15B, ASP238C, ASP277B, ASP2C, ASP316C, ASP43B, ASP75C, ASP89B, CYS130B, CYS202B, CYS225C, CYS283B, CYS289B, GLN169C, GLN182C, GLN219C, GLN259C, GLN266B, GLN266C, GLN52C, GLN84B, GLN84C, GLN97B, GLU212C, GLU293B, GLU48B, GLU57B, GLU95B, GLY173C, GLY198B, GLY249B, GLY249C, GLY262C, GLY281B, GLY82C, HIS101B, HIS101C, HIS113C, HIS165C, HIS299B, HIS83C, ILE103C, ILE110C, ILE124B, ILE124C, ILE199B, ILE222C, ILE229C, ILE242B, ILE242C, ILE263B, ILE273B, ILE276B, ILE280B, ILE287B, ILE300B, ILE39C, ILE42C, ILE78C, LEU109C, LEU119C, LEU126B, LEU128B, LEU134B, LEU148B, LEU174C, LEU178C, LEU217C, LEU218C, LEU227C, LEU248B, LEU248C, LEU253B, LEU253C, LEU254B, LEU254C, LEU267B, LEU291B, LEU292B, LEU296B, LEU317C, LEU35C, LEU53B, LEU53C, LEU55B, LEU55C, LEU6C, LEU79C, LYS100B, LYS100C, LYS105C, LYS156B, LYS163C, LYS171C, LYS274B, LYS41C, LYS4C, LYS96B, MET132B, MET226C, MET256B, MET256C, MET284B, MET47B, MET87B, PHE10C, PHE16B, PHE181C, PHE213C, PHE215C, PHE235C, PHE237C, PHE288B, PHE294B, PHE76C, PHE91B, PHE92B, PRO106C, PRO131B, PRO179C, PRO223C, PRO243B, PRO243C, PRO268B, PRO269B, PRO74C, PRO88B, PRO93B, SER121C, SER125B, SER125C, SER129B, SER150B, SER166C, SER175C, SER176C, SER177C, SER180C, SER193B, SER1C, SER214C, SER231C, SER234C, SER260B, SER265B, SER271B, SER3C, SER40C, SER50C, THR102C, THR154B, THR155B, THR195B, THR197B, THR240B, THR240C, THR247B, THR247C, THR251B, THR251C, THR252B, THR252C, THR255B, THR255C, THR257B, THR285B, THR38C, THR54C, THR80C, THR90B, TRP232C, TRP236C, TRP59B, TRP86B, TYR120B, TYR120C, TYR133B, TYR137C, TYR151B, TYR153B, TYR160B, TYR200B, TYR216C, TYR272B, TYR99B, TYR99C, VAL108B, VAL108C, VAL122B, VAL122C, VAL127B, VAL172C, VAL18B, VAL228C, VAL230C, VAL233C, VAL246B, VAL246C, VAL250B, VAL250C, VAL270B, VAL278B, VAL297B, VAL44B, VAL45B, VAL77C, VAL81C
• B-D: PRO243B, PRO243D
• B-E: PRO243B, PRO243E
• B-F: ARG104F, ARG107F, ARG204B, ASN196B, ASN52F, ASN55F, ASP101F, ASP99F, CYS191B, CYS202B, GLN62F, GLU159B, GLY106F, GLY198B, GLY49F, GLY56F, GLY57F, ILE158B, ILE199B, ILE51F, LEU161B, LEU50F, LYS156B, MET34F, PRO27B, PRO53F, SER193B, SER201B, SER59F, THR154B, THR155B, THR189B, THR192B, THR195B, THR197B, THR33F, THR58F, TRP47F, TYR102F, TYR103F, TYR105F, TYR160B, TYR190B, TYR200B, TYR32F, TYR54F, TYR60F, VAL194B
• B-H: ARG104H, ARG56B, ASN55H, ASP71B, ASP75B, GLN169B, GLN62H, GLN73B, GLY173B, GLY31H, GLY56H, GLY57H, HIS113B, HIS165B, LEU170B, LEU174B, LEU35B, LEU36B, LYS171B, LYS65H, LYS74H, PHE76B, PRO74B, SER166B, SER175B, THR30H, TYR102H, TYR103H, TYR54H, VAL172B
• B-N: ALA28N, ALA2N, ARG19B, ASN24B, ASN33N, ASN54N, ASN55N, ASN96N, ASP157B, ASP23B, GLN1N, GLU159B, GLU164B, GLY25B, GLY26B, GLY27N, HIS97N, ILE158B, ILE199B, ILE32N, ILE53N, LEU161B, LEU203B, LYS156B, PHE34N, PRO27B, SER201B, SER24N, SER25N, SER95N, THR154B, THR155B, THR189B, THR192B, THR22B, THR26N, THR30N, THR31N, TRP162B, TRP93N, TYR160B, TYR190B, TYR94N, VAL194B, VAL28B, VAL29B, VAL29N, VAL30B
• C-D: ALA149C, ALA152C, ALA241D, ALA244C, ALA244D, ALA258C, ALA258D, ALA261C, ALA290C, ALA295C, ALA51D, ALA7D, ALA98C, ARG111D, ARG123C, ARG123D, ARG17C, ARG19C, ARG204C, ARG211D, ARG239D, ARG245C, ARG245D, ARG320D, ARG37D, ARG56D, ARG63C, ASN107D, ASN196C, ASN264C, ASN298C, ASN302C, ASN33D, ASN46C, ASN94C, ASP104D, ASP147C, ASP157C, ASP15C, ASP238D, ASP277C, ASP2D, ASP316D, ASP43C, ASP75D, ASP89C, CYS130C, CYS191C, CYS225D, CYS283C, CYS289C, GLN169D, GLN182D, GLN219D, GLN259D, GLN266C, GLN266D, GLN52D, GLN84C, GLN84D, GLN97C, GLU212D, GLU293C, GLU48C, GLU57C, GLU95C, GLY173D, GLY198C, GLY249C, GLY249D, GLY262D, GLY281C, GLY82D, HIS101C, HIS101D, HIS113D, HIS165D, HIS299C, HIS83D, ILE103D, ILE110D, ILE124C, ILE124D, ILE158C, ILE199C, ILE222D, ILE229D, ILE242C, ILE242D, ILE263C, ILE273C, ILE276C, ILE280C, ILE287C, ILE300C, ILE39D, ILE42D, ILE78D, LEU109D, LEU119D, LEU126C, LEU128C, LEU134C, LEU148C, LEU174D, LEU178D, LEU217D, LEU218D, LEU227D, LEU248C, LEU248D, LEU253C, LEU254C, LEU254D, LEU267C, LEU291C, LEU292C, LEU296C, LEU317D, LEU35D, LEU53C, LEU53D, LEU55C, LEU55D, LEU6D, LEU79D, LYS100C, LYS100D, LYS105D, LYS156C, LYS163D, LYS171D, LYS274C, LYS41D, LYS4D, LYS96C, MET132C, MET226D, MET256C, MET256D, MET284C, MET47C, MET87C, PHE10D, PHE16C, PHE181D, PHE213D, PHE215D, PHE235D, PHE237D, PHE288C, PHE294C, PHE76D, PHE91C, PHE92C, PRO106D, PRO131C, PRO179D, PRO223D, PRO243C, PRO243D, PRO268C, PRO269C, PRO74D, PRO88C, PRO93C, SER121D, SER125C, SER125D, SER129C, SER150C, SER166D, SER175D, SER176D, SER177D, SER180D, SER193C, SER1D, SER214D, SER231D, SER234D, SER260C, SER265C, SER271C, SER3D, SER40D, SER50D, THR102D, THR154C, THR155C, THR195C, THR197C, THR240C, THR240D, THR247C, THR247D, THR251C, THR251D, THR252D, THR255C, THR255D, THR257C, THR285C, THR38D, THR54D, THR80D, THR90C, TRP232D, TRP236D, TRP59C, TRP86C, TYR120C, TYR120D, TYR133C, TYR137D, TYR151C, TYR153C, TYR160C, TYR200C, TYR216D, TYR272C, TYR99C, TYR99D, VAL108C, VAL108D, VAL122C, VAL122D, VAL127C, VAL172D, VAL18C, VAL228D, VAL230D, VAL233D, VAL246C, VAL246D, VAL250C, VAL250D, VAL270C, VAL278C, VAL297C, VAL44C, VAL45C, VAL77D, VAL81D
• C-E: PRO243C, PRO243E
• C-F: ARG104F, ARG56C, ASN55F, ASP71C, ASP75C, GLN169C, GLN62F, GLN73C, GLY173C, GLY31F, GLY56F, GLY57F, HIS165C, LEU170C, LEU174C, LEU35C, LYS171C, LYS65F, LYS74F, PHE76C, PRO74C, SER166C, SER175C, THR30F, TYR102F, TYR103F, TYR54F, VAL172C
• C-G: ARG104G, ARG107G, ARG204C, ASN196C, ASN52G, ASN55G, ASP101G, ASP99G, CYS191C, CYS202C, GLN62G, GLU159C, GLY106G, GLY198C, GLY49G, GLY56G, GLY57G, ILE158C, ILE199C, ILE51G, LEU161C, LEU50G, LYS156C, MET34G, PRO27C, PRO53G, SER193C, SER201C, SER59G, THR154C, THR155C, THR189C, THR192C, THR195C, THR197C, THR33G, THR58G, TRP47G, TYR102G, TYR103G, TYR105G, TYR160C, TYR190C, TYR200C, TYR32G, TYR54G, TYR60G, VAL194C
• C-K: ALA28K, ALA2K, ARG19C, ASN24C, ASN33K, ASN54K, ASN55K, ASN96K, ASP157C, ASP23C, GLN1K, GLU159C, GLU164C, GLY25C, GLY26C, GLY27K, HIS97K, ILE158C, ILE199C, ILE32K, ILE53K, LEU161C, LEU203C, LYS156C, PHE34K, PRO27C, SER201C, SER24K, SER95K, THR154C, THR155C, THR189C, THR192C, THR22C, THR26K, THR30K, THR31K, TRP162C, TRP93K, TYR160C, TYR190C, TYR94K, VAL28C, VAL29C, VAL29K, VAL30C
• D-E: ALA149D, ALA152D, ALA241E, ALA244D, ALA244E, ALA258D, ALA258E, ALA261D, ALA295D, ALA51E, ALA7E, ALA98D, ARG111E, ARG123D, ARG123E, ARG17D, ARG19D, ARG204D, ARG211E, ARG239E, ARG245D, ARG245E, ARG320E, ARG37E, ARG56E, ARG63D, ASN107E, ASN196D, ASN264D, ASN298D, ASN302D, ASN33E, ASN46D, ASN94D, ASP104E, ASP147D, ASP157D, ASP15D, ASP238E, ASP277D, ASP2E, ASP43D, ASP75E, ASP89D, CYS130D, CYS225E, GLN169E, GLN182E, GLN219E, GLN259E, GLN266D, GLN266E, GLN52E, GLN84D, GLN84E, GLN97D, GLU212E, GLU293D, GLU48D, GLU57D, GLU95D, GLY173E, GLY198D, GLY249D, GLY249E, GLY262E, GLY281D, GLY82E, HIS101D, HIS101E, HIS113E, HIS165E, HIS299D, HIS83E, ILE103E, ILE110E, ILE124D, ILE124E, ILE199D, ILE222E, ILE229E, ILE242D, ILE242E, ILE263D, ILE273D, ILE276D, ILE280D, ILE287D, ILE300D, ILE39E, ILE42E, ILE78E, LEU109E, LEU119E, LEU126D, LEU128D, LEU134D, LEU148D, LEU174E, LEU178E, LEU217E, LEU218E, LEU227E, LEU248D, LEU248E, LEU253D, LEU254D, LEU254E, LEU267D, LEU291D, LEU292D, LEU296D, LEU317E, LEU35E, LEU53D, LEU53E, LEU55D, LEU55E, LEU6E, LEU79E, LYS100D, LYS100E, LYS105E, LYS156D, LYS163E, LYS171E, LYS274D, LYS41E, LYS4E, LYS96D, MET132D, MET226E, MET256D, MET256E, MET284D, MET47D, MET87D, PHE10E, PHE16D, PHE181E, PHE213E, PHE215E, PHE235E, PHE237E, PHE288D, PHE294D, PHE76E, PHE91D, PHE92D, PRO106E, PRO131D, PRO179E, PRO223E, PRO243D, PRO243E, PRO268D, PRO269D, PRO74E, PRO88D, PRO93D, SER121E, SER125D, SER125E, SER129D, SER150D, SER166E, SER175E, SER176E, SER177E, SER180E, SER193D, SER1E, SER214E, SER231E, SER234E, SER260D, SER265D, SER271D, SER3E, SER40E, SER50E, THR102E, THR154D, THR155D, THR195D, THR197D, THR240D, THR240E, THR247D, THR247E, THR251D, THR251E, THR252D, THR252E, THR255D, THR255E, THR257D, THR285D, THR38E, THR54E, THR80E, THR90D, TRP232E, TRP236E, TRP59D, TRP86D, TYR120D, TYR120E, TYR133D, TYR137E, TYR151D, TYR153D, TYR160D, TYR200D, TYR216E, TYR272D, TYR99D, TYR99E, VAL108D, VAL108E, VAL122D, VAL122E, VAL127D, VAL172E, VAL18D, VAL228E, VAL230E, VAL233E, VAL246D, VAL246E, VAL250D, VAL250E, VAL270D, VAL278D, VAL297D, VAL44D, VAL45D, VAL77E, VAL81E
• D-G: ARG104G, ARG56D, ASN52G, ASN55G, ASP71D, ASP75D, GLN169D, GLN62G, GLN73D, GLY173D, GLY31G, GLY56G, GLY57G, HIS113D, HIS165D, LEU170D, LEU174D, LEU35D, LYS171D, LYS65G, LYS74G, PHE76D, PRO74D, SER166D, SER175D, THR30G, TYR102G, TYR103G, TYR54G, VAL172D
• D-I: ARG104I, ARG107I, ARG204D, ASN196D, ASN52I, ASN55I, ASP101I, ASP99I, CYS191D, CYS202D, GLN62I, GLU159D, GLY106I, GLY198D, GLY49I, GLY56I, GLY57I, ILE158D, ILE199D, ILE51I, LEU161D, LEU50I, LYS156D, MET34I, PRO27D, PRO53I, SER193D, SER201D, SER59I, THR154D, THR155D, THR189D, THR192D, THR195D, THR197D, THR206D, THR33I, THR58I, TRP47I, TYR102I, TYR103I, TYR105I, TYR160D, TYR190D, TYR200D, TYR32I, TYR54I, TYR60I, VAL194D
• D-O: ALA28O, ALA2O, ARG19D, ASN24D, ASN33O, ASN54O, ASN55O, ASN96O, ASP157D, ASP23D, CYS202D, GLN1O, GLU159D, GLU164D, GLY25D, GLY26D, GLY27O, HIS97O, ILE158D, ILE199D, ILE32O, ILE53O, LEU161D, LEU203D, LYS156D, PHE34O, PRO27D, SER201D, SER24O, SER95O, THR154D, THR155D, THR188D, THR189D, THR192D, THR22D, THR26O, THR30O, THR31O, TRP162D, TRP93O, TYR160D, TYR190D, TYR94O, VAL194D, VAL28D, VAL29D, VAL29O, VAL30D
• E-I: ARG104I, ARG56E, ASN55I, ASP71E, ASP75E, GLN169E, GLN62I, GLY173E, GLY31I, GLY56I, GLY57I, HIS165E, LEU170E, LEU174E, LEU35E, LEU36E, LYS171E, LYS65I, LYS74I, PHE76E, PRO74E, SER166E, SER175E, THR30I, TYR102I, TYR103I, TYR54I, VAL172E
• E-J: ARG104J, ARG107J, ARG204E, ASN196E, ASN35J, ASN52J, ASN55J, ASP101J, ASP99J, CYS191E, CYS202E, GLN62J, GLU159E, GLY106J, GLY198E, GLY49J, GLY56J, GLY57J, ILE158E, ILE199E, ILE51J, LEU161E, LEU50J, LYS156E, MET34J, PRO27E, PRO53J, SER193E, SER201E, SER59J, THR154E, THR155E, THR189E, THR192E, THR195E, THR197E, THR206E, THR33J, THR58J, TRP47J, TYR102J, TYR103J, TYR105J, TYR160E, TYR190E, TYR200E, TYR32J, TYR54J, TYR60J, VAL194E
• E-M: ALA28M, ALA2M, ARG19E, ASN24E, ASN33M, ASN54M, ASN55M, ASN96M, ASP157E, ASP23E, GLN1M, GLU159E, GLU164E, GLY25E, GLY26E, GLY27M, HIS97M, ILE158E, ILE199E, ILE32M, ILE53M, LEU161E, LEU203E, LYS156E, PHE34M, PRO27E, SER201E, SER24M, SER25M, SER95M, THR154E, THR155E, THR189E, THR192E, THR22E, THR26M, THR30M, THR31M, TRP162E, TRP93M, TYR160E, TYR190E, TYR94M, VAL28E, VAL29E, VAL29M, VAL30E
• F-N: ALA177F, ALA177N, ALA35N, ALA57N, ALA91N, ALA97F, ARG104F, ARG107F, ARG56N, ARG98F, ASN33N, ASN35F, ASN36N, ASN44F, ASN54N, ASN55N, ASN61F, ASN96N, ASP101F, ASP110F, ASP141N, ASP43N, ASP99F, CYS137N, CYS149F, CYS90N, CYS96F, GLN114F, GLN166N, GLN170N, GLN180F, GLN39F, GLN39N, GLN62F, GLN6N, GLU163N, GLU40N, GLU46F, GLY100F, GLY101N, GLY102N, GLY103N, GLY106F, GLY113F, GLY115F, GLY161N, GLY171F, GLY48N, GLY49F, GLY51N, GLY52N, GLY59N, HIS173F, HIS41F, HIS44N, HIS97N, ILE139N, ILE219F, ILE32N, ILE48F, ILE50N, ILE53N, ILE87N, LEU120N, LEU133F, LEU135N, LEU150F, LEU179F, LEU183N, LEU186F, LEU45F, LEU45N, LEU49N, LEU50F, LEU92N, LYS152F, LYS169N, LYS217F, LYS38F, LYS43F, LYS63F, MET162N, PHE100N, PHE109F, PHE121N, PHE142N, PHE175F, PHE34N, PHE46N, PHE64F, PHE89N, PRO122N, PRO123N, PRO132F, PRO167N, PRO176F, PRO58N, SER117N, SER124N, SER125N, SER129F, SER168N, SER169F, SER170F, SER171N, SER178N, SER179N, SER187F, SER59F, SER95N, THR116F, THR117F, THR119N, THR134N, THR138N, THR140N, THR164N, THR165N, THR174F, THR184N, THR185F, THR31N, THR47N, THR5N, TRP112F, TRP36F, TRP37N, TRP47F, TRP93N, TRP98N, TYR105F, TYR108F, TYR111F, TYR131F, TYR32F, TYR60F, TYR88N, TYR94N, TYR95F, VAL118N, VAL130F, VAL136N, VAL151F, VAL172F, VAL178F, VAL2F, VAL37F, VAL38N, VAL3N, VAL4N, VAL60N, VAL93F, VAL99N
• G-K: ALA133K, ALA134G, ALA177G, ALA177K, ALA35K, ALA57K, ALA91K, ALA97G, ARG104G, ARG107G, ARG56K, ARG98G, ASN172K, ASN33K, ASN35G, ASN36K, ASN44G, ASN54K, ASN55K, ASN61G, ASN96K, ASP101G, ASP110G, ASP141K, ASP43K, ASP99G, CYS137K, CYS149G, CYS90K, CYS96G, GLN114G, GLN166K, GLN170K, GLN180G, GLN39G, GLN39K, GLN62G, GLN6K, GLU126K, GLU127K, GLU129K, GLU163K, GLU40K, GLU46G, GLY100G, GLY101K, GLY102K, GLY103K, GLY106G, GLY113G, GLY115G, GLY148G, GLY161K, GLY171G, GLY48K, GLY49G, GLY51K, GLY52K, GLY59K, HIS173G, HIS41G, HIS44K, HIS97K, ILE139K, ILE219G, ILE32K, ILE48G, ILE50K, ILE53K, ILE87K, LEU120K, LEU128K, LEU133G, LEU135K, LEU150G, LEU179G, LEU181K, LEU183K, LEU186G, LEU209K, LEU45G, LEU45K, LEU49K, LEU50G, LEU92K, LYS132K, LYS152G, LYS174K, LYS217G, LYS38G, LYS43G, LYS63G, MET176K, PHE100K, PHE109G, PHE121K, PHE142K, PHE175G, PHE34K, PHE46K, PHE64G, PHE89K, PRO122K, PRO123K, PRO132G, PRO135G, PRO167K, PRO176G, PRO221G, PRO58K, SER117K, SER124K, SER125K, SER129G, SER168K, SER170G, SER171K, SER178K, SER179K, SER181G, SER187G, SER188G, SER189G, SER59G, SER95K, THR116G, THR117G, THR119K, THR130K, THR134K, THR138K, THR140K, THR164K, THR165K, THR174G, THR182K, THR185G, THR191G, THR31K, THR47K, THR5K, TRP112G, TRP163G, TRP36G, TRP37K, TRP47G, TRP93K, TRP98K, TYR102G, TYR105G, TYR108G, TYR111G, TYR131G, TYR175K, TYR180K, TYR32G, TYR60G, TYR88K, TYR95G, VAL130G, VAL136K, VAL151G, VAL172G, VAL178G, VAL190G, VAL220G, VAL2G, VAL37G, VAL38K, VAL3K, VAL4K, VAL60K, VAL93G, VAL99K
• H-L: ALA133L, ALA134H, ALA138H, ALA139H, ALA177H, ALA177L, ALA35L, ALA57L, ALA91L, ALA97H, ARG104H, ARG107H, ARG56L, ARG98H, ASN131L, ASN142H, ASN172L, ASN33L, ASN35H, ASN36L, ASN44H, ASN54L, ASN55L, ASN61H, ASN96L, ASP101H, ASP110H, ASP141L, ASP43L, ASP99H, CYS137L, CYS149H, CYS90L, CYS96H, GLN114H, GLN166L, GLN170L, GLN180H, GLN39H, GLN39L, GLN62H, GLN6L, GLU126L, GLU127L, GLU129L, GLU163L, GLU40L, GLU46H, GLY100H, GLY101L, GLY102L, GLY103L, GLY106H, GLY113H, GLY115H, GLY136H, GLY148H, GLY153H, GLY161L, GLY171H, GLY48L, GLY49H, GLY51L, GLY52L, GLY59L, HIS173H, HIS41H, HIS44L, HIS97L, ILE139L, ILE219H, ILE32L, ILE48H, ILE50L, ILE53L, ILE87L, LEU120L, LEU128L, LEU133H, LEU135L, LEU147H, LEU150H, LEU179H, LEU181L, LEU183H, LEU183L, LEU186H, LEU209L, LEU45H, LEU45L, LEU49L, LEU50H, LEU92L, LYS132L, LYS152H, LYS169L, LYS174L, LYS207L, LYS217H, LYS218H, LYS38H, LYS41L, LYS43H, LYS63H, MET144H, MET162L, MET176L, PHE100L, PHE109H, PHE121L, PHE142L, PHE175H, PHE34L, PHE46L, PHE64H, PHE89L, PRO122L, PRO123L, PRO132H, PRO135H, PRO167L, PRO176H, PRO58L, SER117L, SER124L, SER125L, SER129H, SER137H, SER168L, SER170H, SER171L, SER178L, SER179L, SER181H, SER187H, SER188H, SER189H, SER208L, SER59H, SER95L, THR116H, THR117H, THR119L, THR130L, THR134L, THR138L, THR140L, THR146H, THR164L, THR165L, THR174H, THR182L, THR185H, THR191H, THR31L, THR47L, THR5L, TRP112H, TRP197H, TRP36H, TRP37L, TRP47H, TRP93L, TRP98L, TYR102H, TYR105H, TYR108H, TYR111H, TYR131H, TYR154H, TYR175L, TYR180L, TYR32H, TYR60H, TYR88L, TYR95H, VAL118L, VAL130H, VAL136L, VAL145H, VAL151H, VAL172H, VAL178H, VAL190H, VAL220H, VAL2H, VAL37H, VAL38L, VAL3L, VAL4L, VAL60L, VAL93H, VAL99L
• I-O: ALA133O, ALA134I, ALA177I, ALA177O, ALA35O, ALA57O, ALA91O, ALA97I, ARG104I, ARG107I, ARG56O, ARG98I, ASN131O, ASN172O, ASN33O, ASN35I, ASN36O, ASN44I, ASN54O, ASN55O, ASN61I, ASN96O, ASP101I, ASP110I, ASP141O, ASP216I, ASP43O, ASP99I, CYS137O, CYS149I, CYS90O, CYS96I, GLN114I, GLN166O, GLN170O, GLN180I, GLN39I, GLN39O, GLN62I, GLN6O, GLU126O, GLU127O, GLU129O, GLU163O, GLU40O, GLU46I, GLY100I, GLY101O, GLY102O, GLY103O, GLY106I, GLY113I, GLY115I, GLY148I, GLY161O, GLY171I, GLY42I, GLY48O, GLY49I, GLY51O, GLY52O, GLY59O, HIS173I, HIS41I, HIS44O, HIS97O, ILE139O, ILE219I, ILE32O, ILE48I, ILE50O, ILE53O, ILE87O, LEU120O, LEU128O, LEU133I, LEU135O, LEU147I, LEU150I, LEU179I, LEU181O, LEU183O, LEU186I, LEU45I, LEU45O, LEU49O, LEU4I, LEU50I, LEU92O, LYS132O, LYS152I, LYS169O, LYS174O, LYS217I, LYS38I, LYS41O, LYS43I, LYS63I, MET144I, MET162O, MET176O, PHE100O, PHE109I, PHE121O, PHE142O, PHE175I, PHE34O, PHE46O, PHE64I, PHE89O, PRO122O, PRO123O, PRO132I, PRO135I, PRO167O, PRO176I, PRO58O, SER117O, SER124O, SER125O, SER129I, SER168O, SER171O, SER178O, SER179O, SER181I, SER187I, SER188I, SER189I, SER59I, SER95O, THR116I, THR117I, THR119O, THR130O, THR134O, THR138O, THR140O, THR146I, THR164O, THR165O, THR174I, THR182O, THR184O, THR185I, THR191I, THR31O, THR47O, THR5O, TRP112I, TRP36I, TRP37O, TRP47I, TRP93O, TRP98O, TYR105I, TYR108I, TYR111I, TYR131I, TYR175O, TYR180O, TYR32I, TYR60I, TYR88O, TYR95I, VAL118O, VAL130I, VAL136O, VAL145I, VAL151I, VAL172I, VAL178I, VAL190I, VAL215I, VAL2I, VAL37I, VAL38O, VAL3O, VAL4O, VAL60O, VAL93I, VAL99O
• J-M: ALA133M, ALA134J, ALA177J, ALA177M, ALA35M, ALA57M, ALA91M, ALA97J, ARG104J, ARG107J, ARG56M, ARG98J, ASN172M, ASN33M, ASN35J, ASN36M, ASN44J, ASN54M, ASN55M, ASN61J, ASN96M, ASP101J, ASP110J, ASP141M, ASP43M, ASP99J, CYS137M, CYS149J, CYS90M, CYS96J, GLN114J, GLN166M, GLN170M, GLN180J, GLN39J, GLN39M, GLN62J, GLN6M, GLU126M, GLU127M, GLU129M, GLU163M, GLU40M, GLU46J, GLY100J, GLY101M, GLY102M, GLY103M, GLY106J, GLY113J, GLY115J, GLY136J, GLY148J, GLY161M, GLY171J, GLY42J, GLY48M, GLY49J, GLY51M, GLY52M, GLY59M, HIS173J, HIS41J, HIS44M, HIS97M, ILE139M, ILE219J, ILE32M, ILE48J, ILE50M, ILE53M, ILE87M, LEU120M, LEU128M, LEU133J, LEU135M, LEU147J, LEU150J, LEU179J, LEU183M, LEU186J, LEU209M, LEU45J, LEU45M, LEU49M, LEU50J, LEU92M, LYS132M, LYS152J, LYS169M, LYS174M, LYS207M, LYS217J, LYS218J, LYS38J, LYS41M, LYS43J, LYS63J, MET144J, MET162M, MET176M, PHE100M, PHE109J, PHE121M, PHE142M, PHE175J, PHE34M, PHE46M, PHE64J, PHE89M, PRO122M, PRO123M, PRO132J, PRO135J, PRO167M, PRO176J, PRO58M, SER117M, SER124M, SER125M, SER129J, SER137J, SER168M, SER169J, SER170J, SER171M, SER178M, SER179M, SER181J, SER187J, SER188J, SER189J, SER208M, SER210M, SER40J, SER59J, SER95M, THR116J, THR117J, THR119M, THR130M, THR134M, THR138M, THR140M, THR146J, THR164M, THR165M, THR174J, THR182M, THR185J, THR191J, THR31M, THR47M, THR5M, TRP112J, TRP188M, TRP197J, TRP36J, TRP37M, TRP47J, TRP93M, TRP98M, TYR105J, TYR108J, TYR111J, TYR131J, TYR175M, TYR180M, TYR32J, TYR60J, TYR88M, TYR95J, VAL118M, VAL130J, VAL136M, VAL145J, VAL151J, VAL172J, VAL178J, VAL190J, VAL220J, VAL2J, VAL37J, VAL38M, VAL3M, VAL4M, VAL60M, VAL93J, VAL99M