3RGB

crystal structure of particulate methane monooxygenase from methylococcus capsulatus (bath)

• Total interactions analyzed: 36
• Total true interactions: 22
• Strongest Interaction:
  • Chains: I-J
  • Int. Res.: 269
  • Norm. En. per Res.: -4.62
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-112.2758	-36.0272	-1058.96	-1207.263	268	45	34	43779	2	22	24
A-C	-2.2391	-25.5698	-158.658	-186.467	96	1	9	7346	2	18	14
A-E	-30.7341	-49.4714	-118.688	-198.8935	70	17	3	5795	5	19	20
A-I	-27.977	-35.0621	-125.597	-188.6361	70	16	3	6029	5	20	20
A-F	0.0	31.7901	-49.7685	-17.9784	39	2	1	2485	0	12	9
A-K	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0
B-C	-65.3197	-28.0308	-716.444	-809.7946	227	58	39	31383	5	20	17
B-I	-2.2658	27.7732	-55.164	-29.6566	38	1	1	2625	0	13	9
B-J	0.0	0.0	-0.1293	-0.1293	8	0	0	50	0	0	0
B-F	0.0	0.0	-0.1147	-0.1147	8	0	0	43	0	0	0
B-K	0.0	0.0	-36.6504	-36.6504	41	3	3	2189	0	1	0
C-F	0.0	0.0	-34.8941	-34.8941	41	2	3	2100	0	1	0
E-I	-33.685	-37.1234	-130.078	-200.8864	71	19	3	5913	5	21	21
E-J	0.0	29.2492	-50.1948	-20.9456	38	0	1	2529	0	12	9
E-F	-105.6258	-36.0204	-1048.07	-1189.7162	269	45	33	43581	1	22	23
E-G	0.0	-23.4477	-154.649	-178.0967	91	1	9	7297	2	16	14
I-J	-128.1349	-37.7217	-1076.93	-1242.7866	269	43	35	44353	1	22	24
I-K	-10.95	-23.7163	-159.515	-194.1813	94	1	9	7463	2	18	13
J-F	0.0	0.0	-0.131	-0.131	8	0	0	49	0	0	0
J-K	-53.1235	-28.5033	-725.115	-806.7418	225	44	38	31120	5	20	17
J-G	0.0	0.0	-35.4335	-35.4335	41	2	3	2106	0	1	0
F-G	-39.2346	-26.6392	-724.369	-790.2427	225	51	33	31161	5	22	17

Interface residues

• A-B: ALA122B, ALA128B, ALA14B, ALA165B, ALA181B, ALA193A, ALA197A, ALA201A, ALA213B, ALA224A, ALA230A, ALA236A, ALA241A, ALA242A, ALA250A, ALA254A, ALA25B, ALA266A, ALA89B, ARG100A, ARG104B, ARG112A, ARG125A, ARG131A, ARG132A, ARG167A, ARG190B, ARG19B, ARG208A, ARG209A, ARG215A, ARG223A, ARG233A, ARG57B, ARG58B, ARG82B, ARG84B, ASN117B, ASN143A, ASN160B, ASN168A, ASN174B, ASN182A, ASN184A, ASN187A, ASN187B, ASN255A, ASN90A, ASP132B, ASP179A, ASP182B, ASP220A, ASP225A, ASP22B, ASP232A, ASP49B, ASP53B, ASP56B, CYS92B, GLN108A, GLN176A, GLN184B, GLN265A, GLU100B, GLU102A, GLU172B, GLU181A, GLU185A, GLU226A, GLU241B, GLU81B, GLY110B, GLY127B, GLY139B, GLY148B, GLY151B, GLY159B, GLY175A, GLY175B, GLY185B, GLY186A, GLY199A, GLY204A, GLY238A, GLY267A, GLY88B, GLY92A, GLY95A, GLY95B, GLY99B, HIS139A, HIS168B, HIS192A, HIS33A, ILE116B, ILE129B, ILE130B, ILE151A, ILE155B, ILE163B, ILE164B, ILE180B, ILE183B, ILE198A, ILE203A, ILE211A, ILE213A, ILE21B, ILE244A, ILE246A, ILE260A, ILE262A, ILE99A, LEU109A, LEU124B, LEU128A, LEU131B, LEU135B, LEU137B, LEU154B, LEU167B, LEU173A, LEU177B, LEU180A, LEU216A, LEU217A, LEU227A, LEU240A, LEU245A, LEU264A, LEU26B, LEU79B, LEU85B, LEU89A, LEU94B, LEU96B, LEU97B, LEU98B, LYS101A, LYS129A, LYS234A, LYS257A, LYS55B, MET136B, MET141A, MET163A, MET176B, MET178B, MET218A, MET237A, MET249A, MET24B, MET251A, MET269A, MET93A, PHE108B, PHE114B, PHE118B, PHE120B, PHE156B, PHE166A, PHE190A, PHE194A, PHE196A, PHE212A, PHE239A, PHE27B, PHE30B, PHE88A, PHE98A, PRO111A, PRO115B, PRO121B, PRO126B, PRO133A, PRO149A, PRO158B, PRO162B, PRO166B, PRO169A, PRO170B, PRO210A, PRO214A, PRO259A, PRO263A, PRO86B, PRO94A, PRO96A, SER103A, SER123B, SER138B, SER164A, SER179B, SER18B, SER207A, SER229A, SER252A, SER253A, SER256A, SER52B, THR112B, THR133B, THR171A, THR172A, THR174A, THR177A, THR188A, THR191B, THR231A, THR243A, THR261A, THR90B, TRP101B, TRP109B, TRP111B, TRP136A, TRP161B, TRP191A, TRP195A, TRP202A, TRP206A, TRP23B, TRP48B, TRP51B, TRP54B, TRP60B, TRP80B, TRP87B, TYR104A, TYR105B, TYR113B, TYR157B, TYR173B, TYR183A, TYR186B, TYR188B, TYR189A, TYR205A, TYR258A, TYR78B, TYR83B, VAL110A, VAL119B, VAL125B, VAL126A, VAL127A, VAL134B, VAL138A, VAL147B, VAL15B, VAL169B, VAL170A, VAL171B, VAL178A, VAL17B, VAL189B, VAL200A, VAL219A, VAL228A, VAL235A, VAL247A, VAL248A, VAL28B, VAL29B, VAL91A, VAL91B, VAL93B, VAL97A
• A-C: ALA221A, ALA270C, ALA76C, ALA82C, ARG132A, ARG165C, ARG209A, ARG215A, ARG375A, ARG43A, ASN131C, ASN143A, ASN90A, ASP135A, ASP166C, ASP168C, ASP220A, ASP283C, ASP378A, ASP79C, CB5.77834-36.51734, CB6.60185-21.26772, CYS279C, GLN161C, GLN264C, GLN276C, GLN38A, GLU226A, GLU280C, GLU35A, GLU372A, GLY147A, GLY148A, GLY273C, GLY275C, GLY34A, GLY70C, GLY77C, GLY92A, GLY95A, HIS137A, HIS139A, HIS33A, HIS33A5, ILE150A, ILE151A, ILE163C, ILE211A, ILE213A, LEU128C, LEU135C, LEU216A, LEU217A, LEU227A, LEU262C, LEU274C, LEU278C, LEU286C, LEU78C, LYS36A, MET141A, MET218A, MET259C, MET93A, PHE132C, PHE212A, PHE266C, PHE269C, PHE81C, PRO149A, PRO210A, PRO214A, PRO94A, PRO96A, SER268C, SER277C, SER37A, SER75C, SER80C, THR162C, THR167C, THR263C, THR265C, TRP136A, TRP156A, TRP159C, TRP74C, TYR267C, TYR374A, VAL164C, VAL219A, VAL224C, VAL282C, VAL373A, VAL91A, VAL97A
• A-E: ALA266E, ALA407A, ARG112E, ARG115E, ARG270E, ARG386A, ARG45A, ASP288A, ASP382A, ASP384A, ASP406A, ASP82A, ASP85A, ASP85E, GLN108E, GLN145E, GLN176E, GLN265E, GLU117E, GLU75A, GLU79A, GLU83A, GLY107E, GLY119A, GLY175E, GLY267E, GLY271E, GLY76A, ILE118A, ILE260E, ILE262E, ILE379A, ILE380A, ILE410A, LEU109E, LEU173E, LEU264E, LEU409A, LYS285A, MET269E, MET414A, PHE413A, PHE41A, PHE74A, PRO111E, PRO259E, PRO263E, PRO294A, PRO383A, PRO408A, PRO411A, PRO78A, PRO84A, SER113E, SER385A, SER412A, THR172E, THR174E, THR261E, THR268E, THR290A, THR80A, TRP77A, TYR291A, TYR381A, VAL114E, VAL293A, VAL73A, VAL81A, VAL86E
• A-I: ALA266A, ALA407I, ARG112A, ARG115A, ARG270A, ARG386I, ARG45I, ASP288I, ASP382I, ASP384I, ASP406I, ASP82I, ASP85A, GLN108A, GLN145A, GLN176A, GLN265A, GLU117A, GLU75I, GLU79I, GLU83I, GLY107A, GLY119I, GLY175A, GLY267A, GLY271A, GLY76I, ILE118I, ILE260A, ILE262A, ILE379I, ILE380I, ILE410I, LEU109A, LEU173A, LEU264A, LEU409I, LYS285I, MET269A, MET272A, MET414I, PHE413I, PHE41I, PHE74I, PRO111A, PRO259A, PRO263A, PRO294I, PRO383I, PRO408I, PRO411I, PRO78I, PRO84I, SER113A, SER385I, SER412I, THR172A, THR174A, THR261A, THR268A, THR290I, THR80I, TRP77I, TYR291I, TYR381I, VAL110A, VAL114A, VAL293I, VAL81I, VAL86A
• A-F: ALA213F, ALA289A, ALA39A, ALA407A, ARG386A, ARG57F, ARG58F, ASN174F, ASP182F, ASP288A, ASP382A, ASP384A, ASP56F, GLU172F, GLY175F, ILE379A, ILE380A, ILE410A, LEU177F, LEU409A, MET176F, MET178F, MET42A, PHE413A, PHE41A, PRO170F, PRO383A, PRO408A, PRO411A, SER385A, SER412A, THR290A, THR80A, TYR173F, TYR291A, TYR381A, VAL169F, VAL171F, VAL293A
• A-K: ARG223A, LYS204K
• B-C: ALA12B, ALA140C, ALA142C, ALA144C, ALA149C, ALA14B, ALA195C, ALA203C, ALA255C, ALA257C, ALA25B, ALA270C, ALA281C, ALA41B, ALA54C, ALA73B, ALA74B, ALA7B, ARG104B, ARG125C, ARG129C, ARG165C, ARG190B, ARG19B, ARG236B, ARG242B, ARG66C, ARG82B, ARG9B, ASN103B, ASN107B, ASN131C, ASN223C, ASN240B, ASP156C, ASP22B, ASP47B, ASP47C, ASP49B, CYS279C, CYS92B, GLN155C, GLN161C, GLN16B, GLN245B, GLN264C, GLN271C, GLN276C, GLN76B, GLU100B, GLU126C, GLU127C, GLU13B, GLU154C, GLU176C, GLU241B, GLU280C, GLU284C, GLU69C, GLY110B, GLY148C, GLY157C, GLY205C, GLY235B, GLY260C, GLY272C, GLY273C, GLY275C, GLY285C, GLY35B, GLY46B, GLY70C, GLY73C, GLY77C, GLY95B, GLY99B, HIS11B, HIS134C, HIS160C, HIS38B, HIS40B, ILE102B, ILE145C, ILE163C, ILE175C, ILE206C, ILE21B, ILE220C, ILE234B, ILE33B, ILE39B, LEU128C, LEU135C, LEU138C, LEU199C, LEU208C, LEU211C, LEU213C, LEU221C, LEU244B, LEU254C, LEU256C, LEU262C, LEU26B, LEU274C, LEU278C, LEU286C, LEU43B, LEU45C, LEU46C, LEU51C, LEU55C, LEU63C, LEU78C, LEU79B, LEU85B, LEU96B, LEU98B, LYS196C, LYS204C, LYS48C, LYS49C, MET219C, MET24B, MET259C, MET42B, MET45B, PHE106B, PHE108B, PHE114B, PHE118B, PHE132C, PHE152C, PHE177C, PHE192C, PHE201C, PHE202C, PHE238B, PHE243B, PHE266C, PHE269C, PHE27B, PHE30B, PHE31B, PHE50B, PHE71B, PRO121B, PRO124C, PRO171C, PRO200C, PRO209C, PRO217C, PRO222C, PRO72B, SER10B, SER150C, SER172C, SER18B, SER207C, SER239B, SER268C, SER277C, SER36B, SER77B, THR112B, THR123C, THR133C, THR153C, THR158C, THR162C, THR170C, THR191B, THR20B, THR261C, THR263C, THR265C, THR44B, THR59C, THR70B, TRP101B, TRP109B, TRP111B, TRP137C, TRP143C, TRP147C, TRP159C, TRP231B, TRP237B, TRP23B, TRP51B, TRP54B, TRP67C, TRP74C, TRP89C, TYR105B, TYR113B, TYR141C, TYR146C, TYR151C, TYR181C, TYR184C, TYR210C, TYR267C, TYR37B, TYR58C, TYR68C, TYR72C, TYR78B, TYR83B, VAL119B, VAL136C, VAL139C, VAL15B, VAL164C, VAL17B, VAL189B, VAL212C, VAL258C, VAL282C, VAL28B, VAL29B, VAL32B, VAL34B, VAL65C, VAL71C, VAL75B, VAL8B
• B-I: ALA213B, ALA289I, ALA39I, ALA407I, ARG386I, ARG57B, ARG58B, ASN174B, ASP288I, ASP382I, ASP384I, ASP56B, GLU172B, GLY175B, ILE379I, ILE380I, ILE410I, LEU177B, LEU409I, MET176B, MET178B, MET42I, PHE413I, PHE41I, PRO170B, PRO383I, PRO408I, PRO411I, SER385I, SER412I, THR290I, THR80I, TYR173B, TYR291I, TYR381I, VAL169B, VAL171B, VAL293I
• B-J: GLN245J, GLY139B, LEU142B, LEU244J, PHE229B, PHE233B, SER140B, TRP237J
• B-F: GLN245B, GLY139F, LEU142F, LEU244B, PHE229F, PHE233F, SER140F, TRP237B
• B-K: ALA145B, ALA213B, ALA221B, ARG165K, ARG58B, ASN223K, ASP168K, GLY216K, ILE146B, ILE206K, ILE220K, ILE225B, LEU142B, LEU208K, LEU211K, LEU221K, LEU226B, MET150B, MET219K, MET223B, PHE143B, PHE169K, PHE189K, PHE218B, PHE218K, PHE219B, PHE222B, PHE229B, PHE233B, PRO214B, PRO217K, PRO222K, SER140B, TRP108K, TYR178K, VAL147B, VAL212K, VAL214K, VAL215B, VAL215K, VAL224K
• C-F: ALA145F, ALA213F, ALA221F, ARG165C, ARG58F, ASN223C, ASP168C, GLY216C, ILE146F, ILE206C, ILE220C, ILE225F, LEU142F, LEU208C, LEU211C, LEU221C, LEU226F, MET150F, MET219C, MET223F, PHE143F, PHE169C, PHE189C, PHE218C, PHE218F, PHE219F, PHE222F, PHE229F, PHE233F, PRO214F, PRO217C, PRO222C, SER140F, TRP108C, TYR178C, VAL147F, VAL212C, VAL214C, VAL215C, VAL215F, VAL224C
• E-I: ALA266I, ALA407E, ARG112I, ARG115I, ARG270I, ARG386E, ARG45E, ASP288E, ASP382E, ASP384E, ASP406E, ASP85E, ASP85I, GLN108I, GLN145I, GLN176I, GLN265I, GLU117I, GLU75E, GLU79E, GLU83E, GLY107I, GLY119E, GLY175I, GLY267I, GLY271I, GLY76E, ILE118E, ILE260I, ILE262I, ILE379E, ILE380E, ILE410E, LEU109I, LEU173I, LEU264I, LEU409E, LYS285E, MET269I, MET272I, MET414E, PHE413E, PHE41E, PHE74E, PRO111I, PRO259I, PRO263I, PRO294E, PRO383E, PRO408E, PRO411E, PRO78E, PRO84E, SER113I, SER385E, SER412E, THR172I, THR174I, THR261I, THR268I, THR290E, THR80E, TRP77E, TYR291E, TYR381E, VAL110I, VAL114I, VAL293E, VAL73E, VAL81E, VAL86I
• E-J: ALA213J, ALA289E, ALA39E, ALA407E, ARG386E, ARG57J, ARG58J, ASN174J, ASP288E, ASP382E, ASP384E, ASP56J, GLU172J, GLY175J, ILE379E, ILE380E, ILE410E, LEU177J, LEU409E, MET176J, MET178J, MET42E, PHE413E, PHE41E, PRO170J, PRO383E, PRO408E, PRO411E, SER385E, SER412E, THR290E, THR80E, TYR173J, TYR291E, TYR381E, VAL169J, VAL171J, VAL293E
• E-F: ALA122F, ALA128F, ALA14F, ALA165F, ALA181F, ALA193E, ALA197E, ALA201E, ALA213F, ALA221E, ALA224E, ALA230E, ALA236E, ALA241E, ALA242E, ALA250E, ALA254E, ALA25F, ALA266E, ALA89F, ARG100E, ARG104F, ARG112E, ARG125E, ARG131E, ARG132E, ARG167E, ARG190F, ARG19F, ARG208E, ARG209E, ARG215E, ARG223E, ARG233E, ARG57F, ARG58F, ARG82F, ARG84F, ASN117F, ASN143E, ASN160F, ASN168E, ASN174F, ASN182E, ASN184E, ASN187E, ASN187F, ASN255E, ASN90E, ASP132F, ASP179E, ASP182F, ASP220E, ASP225E, ASP22F, ASP232E, ASP49F, ASP53F, ASP56F, CYS92F, GLN108E, GLN176E, GLN184F, GLN265E, GLU100F, GLU102E, GLU172F, GLU181E, GLU185E, GLU226E, GLU241F, GLU81F, GLY110F, GLY127F, GLY139F, GLY148F, GLY151F, GLY159F, GLY175E, GLY175F, GLY185F, GLY186E, GLY199E, GLY204E, GLY238E, GLY267E, GLY88F, GLY92E, GLY95E, GLY95F, GLY99F, HIS139E, HIS168F, HIS192E, HIS33E, ILE102F, ILE116F, ILE129F, ILE130F, ILE151E, ILE155F, ILE163F, ILE164F, ILE180F, ILE183F, ILE198E, ILE203E, ILE211E, ILE213E, ILE21F, ILE244E, ILE246E, ILE260E, ILE262E, ILE99E, LEU109E, LEU124F, LEU128E, LEU131F, LEU135F, LEU137F, LEU154F, LEU167F, LEU173E, LEU177F, LEU180E, LEU216E, LEU217E, LEU227E, LEU240E, LEU245E, LEU264E, LEU26F, LEU79F, LEU85F, LEU89E, LEU94F, LEU96F, LEU97F, LEU98F, LYS101E, LYS129E, LYS234E, LYS257E, LYS55F, MET136F, MET141E, MET163E, MET176F, MET178F, MET218E, MET237E, MET249E, MET24F, MET251E, MET269E, MET93E, PHE108F, PHE114F, PHE118F, PHE120F, PHE156F, PHE166E, PHE190E, PHE194E, PHE196E, PHE212E, PHE239E, PHE27F, PHE30F, PHE88E, PHE98E, PRO111E, PRO115F, PRO121F, PRO126F, PRO133E, PRO149E, PRO158F, PRO162F, PRO166F, PRO169E, PRO170F, PRO210E, PRO214E, PRO259E, PRO263E, PRO86F, PRO94E, PRO96E, SER103E, SER123F, SER138F, SER164E, SER179F, SER18F, SER207E, SER229E, SER252E, SER253E, SER256E, SER52F, THR112F, THR133F, THR171E, THR172E, THR174E, THR177E, THR188E, THR191F, THR231E, THR243E, THR261E, THR90F, TRP101F, TRP109F, TRP111F, TRP136E, TRP161F, TRP191E, TRP195E, TRP202E, TRP206E, TRP23F, TRP48F, TRP51F, TRP54F, TRP60F, TRP80F, TRP87F, TYR104E, TYR105F, TYR113F, TYR157F, TYR173F, TYR183E, TYR186F, TYR188F, TYR189E, TYR205E, TYR258E, TYR78F, TYR83F, VAL110E, VAL119F, VAL125F, VAL126E, VAL127E, VAL134F, VAL138E, VAL15F, VAL169F, VAL170E, VAL171F, VAL178E, VAL17F, VAL189F, VAL200E, VAL219E, VAL228E, VAL235E, VAL247E, VAL248E, VAL28F, VAL29F, VAL91E, VAL91F, VAL93F, VAL97E
• E-G: ALA221E, ALA270G, ALA82G, ARG132E, ARG165G, ARG209E, ARG215E, ARG375E, ARG43E, ASN131G, ASN143E, ASN90E, ASP135E, ASP166G, ASP168G, ASP220E, ASP283G, ASP378E, ASP79G, CYS279G, GLN161G, GLN264G, GLN271G, GLN276G, GLN38E, GLU226E, GLU35E, GLY147E, GLY148E, GLY273G, GLY275G, GLY34E, GLY70G, GLY77G, GLY92E, GLY95E, HIS137E, HIS139E, HIS33E, ILE150E, ILE151E, ILE163G, ILE211E, ILE213E, LEU128G, LEU135G, LEU216E, LEU217E, LEU227E, LEU262G, LEU274G, LEU278G, LEU286G, LEU78G, LYS36E, MET141E, MET218E, MET259G, MET93E, PHE132G, PHE212E, PHE266G, PHE269G, PHE81G, PRO149E, PRO210E, PRO214E, PRO94E, PRO96E, SER268G, SER277G, SER37E, SER75G, SER80G, THR162G, THR167G, THR263G, THR265G, TRP136E, TRP156E, TRP159G, TRP74G, TYR267G, TYR374E, VAL164G, VAL219E, VAL224G, VAL282G, VAL373E, VAL91E, VAL97E
• I-J: ALA122J, ALA128J, ALA14J, ALA165J, ALA181J, ALA193I, ALA197I, ALA201I, ALA213J, ALA221I, ALA224I, ALA230I, ALA236I, ALA241I, ALA242I, ALA250I, ALA254I, ALA25J, ALA266I, ALA89J, ARG100I, ARG104J, ARG112I, ARG125I, ARG131I, ARG132I, ARG167I, ARG190J, ARG19J, ARG208I, ARG209I, ARG215I, ARG223I, ARG233I, ARG57J, ARG58J, ARG82J, ARG84J, ASN117J, ASN143I, ASN160J, ASN168I, ASN174J, ASN182I, ASN184I, ASN187I, ASN187J, ASN255I, ASN90I, ASP132J, ASP179I, ASP182J, ASP220I, ASP225I, ASP22J, ASP232I, ASP49J, ASP53J, ASP56J, CYS92J, GLN108I, GLN176I, GLN184J, GLN265I, GLU100J, GLU102I, GLU172J, GLU181I, GLU185I, GLU226I, GLU241J, GLU81J, GLY110J, GLY127J, GLY139J, GLY148J, GLY151J, GLY159J, GLY175I, GLY175J, GLY185J, GLY186I, GLY199I, GLY204I, GLY238I, GLY267I, GLY88J, GLY92I, GLY95I, GLY95J, GLY99J, HIS139I, HIS168J, HIS192I, HIS33I, ILE102J, ILE116J, ILE129J, ILE130J, ILE151I, ILE155J, ILE163J, ILE164J, ILE180J, ILE183J, ILE198I, ILE203I, ILE211I, ILE213I, ILE21J, ILE244I, ILE246I, ILE260I, ILE262I, ILE99I, LEU109I, LEU124J, LEU128I, LEU131J, LEU135J, LEU137J, LEU154J, LEU167J, LEU173I, LEU177J, LEU180I, LEU216I, LEU217I, LEU227I, LEU240I, LEU245I, LEU264I, LEU26J, LEU79J, LEU85J, LEU89I, LEU94J, LEU96J, LEU97J, LEU98J, LYS101I, LYS129I, LYS234I, LYS257I, LYS55J, MET136J, MET141I, MET163I, MET176J, MET178J, MET218I, MET237I, MET249I, MET24J, MET251I, MET269I, MET93I, PHE108J, PHE114J, PHE118J, PHE120J, PHE156J, PHE166I, PHE190I, PHE194I, PHE196I, PHE212I, PHE239I, PHE27J, PHE30J, PHE88I, PHE98I, PRO111I, PRO115J, PRO121J, PRO126J, PRO133I, PRO149I, PRO158J, PRO162J, PRO166J, PRO169I, PRO170J, PRO210I, PRO214I, PRO259I, PRO263I, PRO86J, PRO94I, PRO96I, SER103I, SER123J, SER138J, SER164I, SER179J, SER18J, SER207I, SER229I, SER252I, SER253I, SER256I, SER52J, THR112J, THR133J, THR171I, THR172I, THR174I, THR177I, THR188I, THR191J, THR231I, THR243I, THR261I, THR90J, TRP101J, TRP109J, TRP111J, TRP136I, TRP161J, TRP191I, TRP195I, TRP202I, TRP206I, TRP23J, TRP48J, TRP51J, TRP54J, TRP60J, TRP80J, TRP87J, TYR104I, TYR105J, TYR113J, TYR157J, TYR173J, TYR183I, TYR186J, TYR188J, TYR189I, TYR205I, TYR258I, TYR78J, TYR83J, VAL110I, VAL119J, VAL125J, VAL126I, VAL127I, VAL134J, VAL138I, VAL15J, VAL169J, VAL170I, VAL171J, VAL178I, VAL17J, VAL189J, VAL200I, VAL219I, VAL228I, VAL235I, VAL247I, VAL248I, VAL28J, VAL29J, VAL91I, VAL91J, VAL93J, VAL97I
• I-K: ALA221I, ALA270K, ALA76K, ALA82K, ARG132I, ARG165K, ARG209I, ARG215I, ARG375I, ARG43I, ASN131K, ASN143I, ASN90I, ASP135I, ASP166K, ASP168K, ASP220I, ASP283K, ASP378I, ASP79K, CYS279K, GLN161K, GLN264K, GLN271K, GLN276K, GLN38I, GLU226I, GLU280K, GLU35I, GLY147I, GLY148I, GLY222I, GLY273K, GLY275K, GLY34I, GLY70K, GLY77K, GLY92I, GLY95I, HIS137I, HIS139I, HIS33I, ILE150I, ILE151I, ILE163K, ILE211I, ILE213I, LEU128K, LEU135K, LEU216I, LEU217I, LEU227I, LEU262K, LEU274K, LEU278K, LEU286K, LEU78K, LYS36I, MET141I, MET218I, MET259K, MET93I, PHE132K, PHE212I, PHE266K, PHE269K, PHE81K, PRO149I, PRO210I, PRO214I, PRO94I, PRO96I, SER268K, SER277K, SER37I, SER75K, SER80K, THR162K, THR167K, THR263K, THR265K, TRP136I, TRP156I, TRP159K, TRP74K, TYR267K, TYR374I, VAL164K, VAL219I, VAL224K, VAL282K, VAL373I, VAL91I, VAL97I
• J-F: GLN245F, GLY139J, LEU142J, LEU244F, PHE229J, PHE233J, SER140J, TRP237F
• J-K: ALA12J, ALA140K, ALA142K, ALA144K, ALA149K, ALA14J, ALA195K, ALA203K, ALA255K, ALA257K, ALA25J, ALA270K, ALA281K, ALA41J, ALA54K, ALA73J, ALA74J, ALA7J, ARG104J, ARG125K, ARG129K, ARG165K, ARG190J, ARG19J, ARG236J, ARG242J, ARG66K, ARG82J, ARG9J, ASN103J, ASN107J, ASN131K, ASN223K, ASN240J, ASP156K, ASP22J, ASP47J, ASP47K, ASP49J, CYS92J, GLN155K, GLN161K, GLN16J, GLN245J, GLN264K, GLN271K, GLN276K, GLN76J, GLU100J, GLU126K, GLU127K, GLU13J, GLU154K, GLU176K, GLU241J, GLU280K, GLU284K, GLU69K, GLY110J, GLY148K, GLY157K, GLY205K, GLY235J, GLY260K, GLY272K, GLY273K, GLY275K, GLY285K, GLY35J, GLY46J, GLY70K, GLY73K, GLY77K, GLY95J, GLY99J, HIS11J, HIS134K, HIS160K, HIS38J, HIS40J, ILE102J, ILE145K, ILE163K, ILE175K, ILE206K, ILE21J, ILE220K, ILE234J, ILE33J, ILE39J, LEU128K, LEU135K, LEU138K, LEU199K, LEU208K, LEU211K, LEU213K, LEU221K, LEU244J, LEU254K, LEU256K, LEU262K, LEU26J, LEU274K, LEU278K, LEU286K, LEU43J, LEU45K, LEU46K, LEU51K, LEU55K, LEU63K, LEU78K, LEU79J, LEU85J, LEU96J, LEU98J, LYS196K, LYS204K, LYS48K, LYS49K, MET219K, MET24J, MET259K, MET42J, MET45J, PHE106J, PHE108J, PHE114J, PHE118J, PHE132K, PHE152K, PHE177K, PHE192K, PHE201K, PHE202K, PHE238J, PHE243J, PHE266K, PHE269K, PHE27J, PHE30J, PHE31J, PHE50J, PHE71J, PRO121J, PRO124K, PRO171K, PRO200K, PRO209K, PRO217K, PRO222K, PRO72J, SER10J, SER150K, SER172K, SER18J, SER207K, SER239J, SER268K, SER277K, SER36J, SER77J, THR112J, THR123K, THR133K, THR153K, THR158K, THR162K, THR170K, THR191J, THR20J, THR261K, THR263K, THR265K, THR44J, THR59K, THR70J, TRP101J, TRP109J, TRP111J, TRP137K, TRP143K, TRP147K, TRP159K, TRP231J, TRP237J, TRP23J, TRP51J, TRP67K, TRP74K, TRP89K, TYR105J, TYR113J, TYR141K, TYR146K, TYR151K, TYR181K, TYR184K, TYR210K, TYR267K, TYR37J, TYR58K, TYR68K, TYR72K, TYR78J, TYR83J, VAL119J, VAL136K, VAL139K, VAL15J, VAL164K, VAL17J, VAL189J, VAL212K, VAL258K, VAL282K, VAL28J, VAL29J, VAL32J, VAL34J, VAL65K, VAL71K, VAL75J, VAL8J
• J-G: ALA145J, ALA213J, ALA221J, ARG165G, ARG58J, ASN223G, ASP168G, GLY216G, ILE146J, ILE206G, ILE220G, ILE225J, LEU142J, LEU208G, LEU211G, LEU221G, LEU226J, MET150J, MET219G, MET223J, PHE143J, PHE169G, PHE189G, PHE218G, PHE218J, PHE219J, PHE222J, PHE229J, PHE233J, PRO214J, PRO217G, PRO222G, SER140J, TRP108G, TYR178G, VAL147J, VAL212G, VAL214G, VAL215G, VAL215J, VAL224G
• F-G: ALA12F, ALA140G, ALA142G, ALA144G, ALA149G, ALA14F, ALA195G, ALA203G, ALA255G, ALA257G, ALA25F, ALA270G, ALA281G, ALA41F, ALA54G, ALA73F, ALA74F, ALA7F, ARG104F, ARG125G, ARG129G, ARG165G, ARG190F, ARG19F, ARG236F, ARG242F, ARG66G, ARG82F, ARG9F, ASN103F, ASN107F, ASN131G, ASN223G, ASN240F, ASP156G, ASP22F, ASP283G, ASP47F, ASP47G, ASP49F, CYS92F, GLN155G, GLN161G, GLN16F, GLN245F, GLN264G, GLN271G, GLN276G, GLN76F, GLU100F, GLU126G, GLU127G, GLU13F, GLU154G, GLU176G, GLU241F, GLU280G, GLU284G, GLU69G, GLY110F, GLY148G, GLY157G, GLY205G, GLY235F, GLY260G, GLY272G, GLY273G, GLY275G, GLY285G, GLY35F, GLY46F, GLY70G, GLY73G, GLY77G, GLY95F, GLY99F, HIS11F, HIS134G, HIS160G, HIS38F, HIS40F, ILE102F, ILE145G, ILE163G, ILE175G, ILE206G, ILE21F, ILE220G, ILE234F, ILE33F, ILE39F, LEU128G, LEU135G, LEU138G, LEU208G, LEU211G, LEU213G, LEU221G, LEU244F, LEU254G, LEU256G, LEU262G, LEU26F, LEU274G, LEU278G, LEU286G, LEU43F, LEU45G, LEU46G, LEU51G, LEU55G, LEU63G, LEU78G, LEU79F, LEU85F, LEU96F, LEU98F, LYS196G, LYS204G, LYS48G, LYS49G, MET219G, MET24F, MET259G, MET42F, MET45F, PHE106F, PHE108F, PHE114F, PHE118F, PHE132G, PHE152G, PHE177G, PHE192G, PHE201G, PHE202G, PHE238F, PHE243F, PHE266G, PHE269G, PHE27F, PHE30F, PHE31F, PHE50F, PHE71F, PRO121F, PRO124G, PRO171G, PRO200G, PRO209G, PRO217G, PRO222G, PRO72F, SER10F, SER150G, SER172G, SER18F, SER207G, SER239F, SER268G, SER277G, SER36F, SER77F, THR112F, THR123G, THR133G, THR153G, THR158G, THR162G, THR170G, THR191F, THR20F, THR261G, THR263G, THR265G, THR44F, THR59G, THR70F, TRP101F, TRP109F, TRP111F, TRP137G, TRP143G, TRP147G, TRP159G, TRP231F, TRP237F, TRP23F, TRP51F, TRP67G, TRP74G, TRP89G, TYR105F, TYR113F, TYR141G, TYR146G, TYR151G, TYR181G, TYR184G, TYR210G, TYR267G, TYR37F, TYR58G, TYR68G, TYR72G, TYR78F, TYR83F, VAL119F, VAL136G, VAL139G, VAL15F, VAL164G, VAL17F, VAL189F, VAL212G, VAL258G, VAL282G, VAL28F, VAL29F, VAL32F, VAL34F, VAL65G, VAL71G, VAL75F, VAL8F