3RFR

crystal structure of particulate methane monooxygenase (pmmo) from methylocystis sp. strain m

• Total interactions analyzed: 55
• Total true interactions: 26
• Strongest Interaction:
  • Chains: F-E
  • Int. Res.: 292
  • Norm. En. per Res.: -4.4248
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-J	0.0	0.0	-0.0184	-0.0184	3	0	0	15	0	1	0
A-B	-101.5778	-25.9425	-1141.59	-1269.1103	292	37	41	47107	1	36	31
A-F	-12.3025	-0.2312	-205.153	-217.6868	90	15	4	8826	1	21	18
A-C	-18.582	-24.4415	-150.044	-193.0675	85	11	6	7087	1	24	20
A-E	-24.8252	-33.0552	-102.283	-160.1634	64	9	1	5108	3	10	6
A-I	-24.2999	-34.6137	-99.401	-158.3146	62	9	1	4904	3	10	6
D-C	0.0	0.0	-73.7158	-73.7158	58	4	14	3807	0	0	0
H-G	0.0	0.0	-61.5306	-61.5306	49	2	15	3619	0	0	0
J-B	0.0	0.0	-28.5597	-28.5597	24	2	2	1778	0	1	0
J-F	0.0	0.0	-24.6604	-24.6604	23	0	1	1615	0	1	0
J-G	0.0	30.0938	-66.1638	-36.07	62	0	3	3298	0	7	6
J-K	-114.1385	-21.955	-701.18	-837.2734	235	41	28	31547	7	15	19
J-E	-18.1091	-1.5313	-204.974	-224.6144	87	17	4	8885	1	22	17
J-I	-102.0453	-24.3256	-1127.77	-1254.1409	294	39	39	46881	1	37	29
B-F	0.0	0.0	-27.4681	-27.4681	24	0	2	1695	0	1	0
B-C	-101.0511	-22.4399	-705.716	-829.207	224	31	28	30667	7	15	19
B-K	0.0	30.4838	-69.7814	-39.2976	61	1	4	3463	0	7	6
B-E	0.0	0.0	-0.008	-0.008	3	0	0	8	0	1	0
B-I	-12.507	-0.8764	-207.929	-221.3125	87	18	4	8896	1	21	17
F-C	0.0	26.671	-63.6178	-36.9468	61	2	3	3297	0	7	6
F-G	-118.6106	-20.3666	-740.209	-879.1861	230	41	28	31153	7	16	19
F-E	-129.0202	-25.7252	-1137.31	-1292.0554	292	47	41	46966	1	36	32
F-I	0.0	0.0	-0.0059	-0.0059	3	0	0	6	0	1	0
G-E	-13.2737	-21.712	-153.411	-188.3967	84	13	6	7183	1	26	21
K-I	-18.4052	-22.7574	-157.285	-198.4477	85	11	6	7317	1	25	21
E-I	-12.2514	-32.2083	-103.599	-148.0588	63	6	1	4991	3	10	6

Interface residues

• A-J: GLN251J, PRO220A, VAL215A
• A-B: ALA106A, ALA128B, ALA133B, ALA168B, ALA170B, ALA171B, ALA175B, ALA186A, ALA186B, ALA193A, ALA196A, ALA197A, ALA19B, ALA210A, ALA216A, ALA233A, ALA237A, ALA242A, ALA248A, ALA24B, ALA262A, ALA87A, ALA94B, ALA97B, ALA98A, ARG108A, ARG109B, ARG125A, ARG127A, ARG128A, ARG183A, ARG195B, ARG203B, ARG205A, ARG207B, ARG214A, ARG219A, ARG229A, ARG230A, ARG256A, ARG62B, ARG63B, ARG89B, ARG96A, ASN123A, ASN139A, ASN164B, ASN165B, ASN178A, ASN251A, ASN86A, ASN87B, ASP137B, ASP164A, ASP170A, ASP175A, ASP187B, ASP221A, ASP222A, ASP226A, ASP227A, ASP228A, ASP27B, ASP54B, ASP58B, ASP61B, CYS22B, GLN104A, GLN137A, GLN174B, GLN178B, GLN181B, GLN261A, GLN265A, GLN99A, GLU105B, GLU141A, GLU177A, GLU177B, GLU200B, GLU206B, GLU89A, GLY100B, GLY104B, GLY115B, GLY142A, GLY143A, GLY144A, GLY144B, GLY156B, GLY171A, GLY180A, GLY180B, GLY190B, GLY195A, GLY207A, GLY208B, GLY218A, GLY225A, GLY232A, GLY246A, GLY263A, GLY88A, GLY91A, GLY93B, HIS173B, HIS179B, HIS188A, HIS192B, HIS29A, ILE103B, ILE107B, ILE121B, ILE122A, ILE130B, ILE134B, ILE138A, ILE139B, ILE146A, ILE147A, ILE169B, ILE181A, ILE184A, ILE189B, ILE199A, ILE202B, ILE204A, ILE208A, ILE209A, ILE224A, ILE231A, ILE234A, ILE240A, ILE244A, ILE258A, LEU101B, LEU123B, LEU124A, LEU136B, LEU140B, LEU141B, LEU142B, LEU159B, LEU160B, LEU168A, LEU169A, LEU176A, LEU182B, LEU185B, LEU188B, LEU189A, LEU191B, LEU192A, LEU200A, LEU236A, LEU238A, LEU260A, LEU264A, LEU30B, LEU31B, LEU33B, LEU34B, LEU85A, LEU90B, LEU94A, LEU99B, LYS160A, LYS206A, LYS60B, MET102B, MET129B, MET159A, MET183B, MET198B, MET204B, MET29B, MET64B, PHE100A, PHE105A, PHE113B, PHE119B, PHE125B, PHE13B, PHE161B, PHE162A, PHE172B, PHE193B, PHE201A, PHE203A, PHE254A, PHE35B, PHE83B, PHE84A, PHE88B, PHE92B, PHE96B, PRO107A, PRO120B, PRO126B, PRO132B, PRO145A, PRO163B, PRO165A, PRO167B, PRO190A, PRO199B, PRO219B, PRO220A, PRO255A, PRO259A, PRO90A, PRO91B, PRO92A, SER109A, SER122B, SER127B, SER143B, SER172A, SER182A, SER197B, SER211A, SER252A, SER83A, THR117B, THR163A, THR167A, THR173A, THR176B, THR184B, THR196B, THR239A, THR243A, THR246B, THR250A, THR253A, THR257A, THR25B, THR26B, THR97A, TRP106B, TRP114B, TRP116B, TRP132A, TRP135B, TRP166B, TRP187A, TRP191A, TRP198A, TRP202A, TRP28B, TRP53B, TRP56B, TRP59B, TRP65B, TRP84B, TRP85B, TYR110B, TYR118B, TYR162B, TYR179A, TYR185A, TYR201B, TYR212A, TYR247A, VAL110A, VAL124B, VAL131B, VAL134A, VAL138B, VAL140A, VAL166A, VAL174A, VAL194A, VAL194B, VAL205B, VAL213A, VAL215A, VAL217B, VAL218B, VAL223A, VAL235A, VAL23B, VAL245A, VAL249A, VAL32B, VAL57B, VAL82A, VAL86B, VAL93A, VAL95A, VAL95B, VAL98B
• A-F: ALA175F, ALA36A, ALA380A, ALA76A, ALA78A, ARG203F, ARG207F, ARG211F, ARG375A, ARG39A, ARG41A, ARG62F, ARG63F, ASN139A, ASN289A, ASP187F, ASP216F, ASP378A, ASP382A, ASP384A, ASP61F, GLN174F, GLN178F, GLN181F, GLN34A, GLN35A, GLN386A, GLN75A, GLU141A, GLU177F, GLU200F, GLU206F, GLU31A, GLY142A, GLY143A, GLY144A, GLY180F, GLY208F, GLY214F, GLY290A, GLY291A, GLY30A, GLY407A, HIS173F, HIS179F, HIS29A, ILE138A, ILE146A, ILE147A, ILE410A, LEU182F, LEU210F, LEU379A, LEU38A, LEU43A, LYS215F, LYS32A, LYS412A, MET183F, MET204F, MET40A, PHE213F, PHE37A, PHE413A, PRO145A, PRO219F, PRO408A, PRO411A, PRO74A, SER33A, SER385A, THR176F, THR184F, THR209F, THR212F, THR383A, THR42A, TRP73A, TYR201F, TYR293A, TYR381A, VAL140A, VAL205F, VAL217F, VAL218F, VAL220F, VAL292A, VAL295A, VAL409A, VAL77A
• A-C: 8100CB6.9795, ALA131C, ALA210A, ALA216A, ALA244C, ALA252C, ALA55C, ALA87A, ARG128A, ARG131A, ARG138C, ARG214A, ARG241C, ARG375A, ARG39A, ARG48C, ASN139A, ASN86A, ASP139C, ASP222A, ASP52C, CB4.71348-39.47440, GLN137A, GLN237C, GLN34A, GLN43C, GLU217A, GLU249C, GLU31A, GLU89A, GLY130A, GLY144A, GLY148A, GLY218A, GLY240C, GLY247C, GLY250C, GLY30A, GLY46C, GLY88A, GLY91A, HIS133A, HIS135A, HIS243C, HIS29A, HIS29A5, ILE137C, ILE146A, ILE147A, ILE208A, ILE209A, ILE238C, ILE242C, ILE246C, ILE373A, LEU104C, LEU236C, LEU239C, LEU51C, LYS206A, LYS32A, MET101C, MET134C, PHE54C, PRO145A, PRO90A, PRO92A, SER211A, SER33A, SER53C, THR135C, THR140C, TRP132A, TRP132C, TRP152A, TRP47C, TYR212A, VAL105C, VAL108C, VAL136C, VAL213A, VAL215A, VAL235C, VAL251C, VAL93A
• A-E: ALA262E, ALA380A, ALA72A, ALA76A, ALA78A, ARG108E, ARG256E, ARG41A, ARG81E, ASN289A, ASN79A, ASP170E, ASP382A, ASP384A, GLN104E, GLN261E, GLN265E, GLN35A, GLN386A, GLN75A, GLU141E, GLU287A, GLU404A, GLY263E, GLY290A, GLY406A, GLY407A, ILE114A, ILE258E, ILE405A, ILE410A, LEU169E, LEU260E, LEU264E, LEU288A, LEU379A, LYS266E, LYS412A, PHE105E, PHE37A, PHE413A, PHE70A, PRO255E, PRO259E, PRO267E, PRO296A, PRO408A, PRO411A, PRO74A, SER109E, SER385A, SER71A, THR257E, THR286A, THR383A, TRP73A, TYR293A, TYR381A, VAL292A, VAL295A, VAL409A, VAL414A, VAL77A, VAL82E
• A-I: ALA262A, ALA380I, ALA72I, ALA76I, ALA78I, ARG108A, ARG256A, ARG41I, ARG81A, ASN289I, ASN79I, ASP170A, ASP382I, ASP384I, GLN104A, GLN261A, GLN265A, GLN35I, GLN386I, GLN75I, GLU141A, GLU287I, GLU404I, GLY263A, GLY406I, GLY407I, ILE114I, ILE258A, ILE410I, LEU169A, LEU260A, LEU264A, LEU288I, LEU379I, LYS266A, LYS412I, PHE105A, PHE37I, PHE413I, PHE70I, PRO255A, PRO259A, PRO267A, PRO296I, PRO408I, PRO411I, PRO74I, SER109A, SER385I, SER71I, THR257A, THR286I, THR383I, TRP73I, TYR293I, TYR381I, VAL292I, VAL295I, VAL409I, VAL414I, VAL77I, VAL82A
• D-C: ALA10D, ALA11D, ALA12D, ALA13D, ALA14D, ALA15D, ALA16D, ALA17D, ALA18D, ALA19D, ALA1D, ALA2D, ALA3D, ALA4D, ALA5D, ALA6D, ALA7D, ALA8D, ALA9D, ARG171C, ARG22C, GLN59C, GLU69C, GLU73C, GLY23C, GLY27C, ILE148C, ILE156C, ILE26C, ILE37C, ILE65C, LEU31C, LEU66C, LEU72C, LEU80C, LEU84C, MET152C, MET63C, PHE34C, PHE45C, PRO71C, SER64C, SER76C, THR60C, THR68C, THR87C, TRP110C, TRP62C, TRP67C, TYR35C, TYR41C, TYR61C, TYR83C, VAL159C, VAL30C, VAL33C, VAL38C, VAL75C
• H-G: ALA10H, ALA11H, ALA12H, ALA13H, ALA14H, ALA15H, ALA16H, ALA17H, ALA18H, ALA19H, ALA4H, ALA5H, ALA6H, ALA7H, ALA8H, ALA9H, ARG22G, GLU42G, GLU69G, GLU73G, GLY23G, GLY27G, ILE148G, ILE156G, ILE26G, ILE37G, ILE65G, LEU31G, LEU66G, LEU72G, LEU80G, MET152G, MET63G, PHE34G, PHE45G, SER64G, SER76G, THR60G, THR68G, TRP62G, TRP67G, TYR41G, TYR61G, VAL159G, VAL30G, VAL33G, VAL38G, VAL44G, VAL75G
• J-B: ARG211B, ARG241B, ARG89B, ASN87B, GLN251J, GLY144B, ILE148B, ILE202J, ILE249J, ILE252J, LEU140B, PHE234B, PHE238B, PRO199J, SER143B, SER145B, SER197J, THR149B, TRP237B, TRP85B, TYR146B, TYR201J, VAL147B, VAL86B
• J-F: ARG211J, ARG241J, ARG89J, GLN251F, GLY144J, ILE148J, ILE202F, ILE249F, ILE252F, LEU140J, PHE234J, PHE238J, PRO199F, SER143J, SER145J, SER197F, THR149J, TRP237J, TRP85J, TYR146J, TYR201F, VAL147J, VAL86J
• J-G: ALA150J, ALA187G, ARG138G, ARG211J, ARG63J, ASN196G, ASP139G, ASP141G, ASP216J, GLY189G, GLY214J, GLY226J, HIS133G, ILE137G, ILE148J, ILE188G, ILE193G, ILE194G, LEU155J, LEU181G, LEU184G, LEU210J, LEU235J, LEU74G, LEU78G, LYS215J, MET192G, MET230J, MET231J, PHE142G, PHE166G, PHE191G, PHE213J, PHE223J, PHE224G, PHE224J, PHE227J, PHE234J, PHE238J, PHE54G, PRO190G, PRO195G, PRO219J, SER145J, SER154J, SER229J, SER53G, THR140G, THR209J, THR212J, TRP226G, TYR146J, TYR151G, TYR179G, TYR233J, VAL147J, VAL151J, VAL152J, VAL197G, VAL220J, VAL228J, VAL232J
• J-K: ALA117K, ALA122K, ALA131K, ALA176K, ALA182K, ALA19J, ALA20J, ALA228K, ALA244K, ALA24J, ALA252K, ALA37J, ALA78J, ALA79J, ALA82J, ALA96K, ALA97J, ARG102K, ARG109J, ARG138K, ARG195J, ARG241J, ARG241K, ARG248J, ARG39K, ARG98K, ASN108J, ASN112J, ASN14J, ASN196K, ASN87J, ASP129K, ASP20K, ASP27J, ASP52J, ASP54J, CYS22J, CYS77J, GLN109K, GLN128K, GLN237K, GLN251J, GLN43K, GLN81J, GLU100K, GLU105J, GLU127K, GLU149K, GLU16K, GLU18J, GLU249K, GLU250J, GLU42K, GLU99K, GLY100J, GLY104J, GLY115J, GLY115K, GLY11J, GLY121K, GLY130K, GLY178K, GLY21J, GLY225K, GLY230K, GLY233K, GLY240J, GLY240K, GLY247K, GLY40J, GLY41J, GLY46K, GLY50K, GLY51J, GLY93J, HIS133K, HIS146K, HIS177K, HIS43J, HIS45J, ILE103J, ILE107J, ILE116K, ILE118K, ILE137K, ILE148K, ILE185K, ILE188K, ILE193K, ILE194K, ILE202J, ILE238K, ILE242K, ILE246K, ILE249J, ILE252J, ILE71J, LEU101J, LEU104K, LEU107K, LEU111K, LEU123J, LEU181K, LEU184K, LEU21K, LEU229K, LEU235J, LEU236K, LEU239K, LEU245K, LEU28K, LEU30J, LEU31J, LEU33J, LEU34J, LEU36K, LEU39J, LEU48J, LEU51K, LEU72J, LYS169K, LYS247J, LYS248K, MET101K, MET134K, MET198J, MET227K, MET231J, MET239J, MET24K, MET29J, MET47J, PHE113J, PHE119J, PHE124K, PHE125K, PHE13J, PHE150K, PHE165K, PHE175K, PHE183K, PHE193J, PHE224K, PHE232K, PHE35J, PHE36J, PHE45K, PHE46J, PHE55J, PHE76J, PHE83J, PHE88J, PHE96J, PRO126J, PRO12J, PRO144K, PRO195K, PRO199J, PRO97K, SER123K, SER145K, SER15J, SER17K, SER180K, SER197J, SER229J, SER244J, SER80J, THR117J, THR126K, THR135K, THR143K, THR196J, THR245J, THR246J, THR25J, THR26J, THR49J, THR75J, TRP106J, TRP110K, TRP114J, TRP116J, TRP120K, TRP132K, TRP226K, TRP236J, TRP237J, TRP242J, TRP25K, TRP28J, TRP47K, TRP56J, TRP59J, TRP62K, TRP84J, TYR110J, TYR114K, TYR118J, TYR119K, TYR154K, TYR157K, TYR174K, TYR179K, TYR233J, TYR243J, TYR41K, TYR42J, VAL105K, VAL106K, VAL108K, VAL111J, VAL112K, VAL113K, VAL124J, VAL136K, VAL16J, VAL186K, VAL18K, VAL194J, VAL19K, VAL228J, VAL231K, VAL232J, VAL234K, VAL235K, VAL23J, VAL251K, VAL32J, VAL38J, VAL44J, VAL44K, VAL68J, VAL74J, VAL86J
• J-E: ALA175J, ALA380E, ALA76E, ALA78E, ARG203J, ARG207J, ARG211J, ARG375E, ARG39E, ARG41E, ARG62J, ARG63J, ASN139E, ASN289E, ASP187J, ASP216J, ASP378E, ASP382E, ASP384E, ASP61J, GLN174J, GLN178J, GLN181J, GLN34E, GLN35E, GLN386E, GLN75E, GLU141E, GLU177J, GLU200J, GLU206J, GLU31E, GLY142E, GLY143E, GLY144E, GLY180J, GLY208J, GLY214J, GLY290E, GLY291E, GLY30E, GLY407E, HIS173J, HIS179J, HIS29E, ILE138E, ILE146E, ILE147E, ILE410E, LEU182J, LEU210J, LEU379E, LEU38E, LEU43E, LYS215J, LYS32E, MET183J, MET204J, MET40E, PHE213J, PHE37E, PHE413E, PRO145E, PRO219J, PRO408E, PRO411E, PRO74E, SER33E, SER385E, THR176J, THR184J, THR209J, THR212J, THR383E, THR42E, TRP73E, TYR201J, TYR293E, TYR381E, VAL140E, VAL205J, VAL217J, VAL218J, VAL292E, VAL295E, VAL409E, VAL77E
• J-I: ALA106I, ALA128J, ALA133J, ALA168J, ALA170J, ALA171J, ALA175J, ALA186I, ALA186J, ALA193I, ALA196I, ALA197I, ALA19J, ALA210I, ALA216I, ALA233I, ALA237I, ALA242I, ALA248I, ALA24J, ALA262I, ALA87I, ALA94J, ALA97J, ALA98I, ARG108I, ARG109J, ARG125I, ARG127I, ARG128I, ARG183I, ARG195J, ARG203J, ARG205I, ARG207J, ARG214I, ARG219I, ARG229I, ARG230I, ARG256I, ARG62J, ARG63J, ARG89J, ARG96I, ASN123I, ASN139I, ASN164J, ASN165J, ASN178I, ASN251I, ASN86I, ASN87J, ASP137J, ASP164I, ASP170I, ASP175I, ASP187J, ASP221I, ASP222I, ASP226I, ASP227I, ASP228I, ASP27J, ASP54J, ASP58J, ASP61J, CYS22J, GLN104I, GLN137I, GLN174J, GLN178J, GLN181J, GLN261I, GLN265I, GLN99I, GLU105J, GLU141I, GLU177I, GLU177J, GLU200J, GLU206J, GLU89I, GLY100J, GLY104J, GLY115J, GLY142I, GLY143I, GLY144I, GLY144J, GLY153J, GLY156J, GLY171I, GLY180I, GLY180J, GLY190J, GLY195I, GLY207I, GLY208J, GLY218I, GLY225I, GLY232I, GLY246I, GLY263I, GLY88I, GLY91I, GLY93J, HIS173J, HIS179J, HIS188I, HIS192J, HIS29I, ILE103J, ILE107J, ILE121J, ILE122I, ILE130J, ILE134J, ILE138I, ILE139J, ILE146I, ILE147I, ILE169J, ILE181I, ILE184I, ILE189J, ILE199I, ILE202J, ILE204I, ILE208I, ILE209I, ILE224I, ILE231I, ILE234I, ILE240I, ILE244I, ILE258I, LEU101J, LEU123J, LEU124I, LEU136J, LEU140J, LEU141J, LEU142J, LEU159J, LEU160J, LEU168I, LEU169I, LEU176I, LEU182J, LEU185J, LEU188J, LEU189I, LEU191J, LEU192I, LEU200I, LEU236I, LEU238I, LEU260I, LEU264I, LEU30J, LEU31J, LEU33J, LEU34J, LEU85I, LEU90J, LEU94I, LEU99J, LYS160I, LYS206I, LYS60J, MET102J, MET129J, MET159I, MET183J, MET198J, MET204J, MET29J, MET64J, PHE100I, PHE105I, PHE113J, PHE119J, PHE125J, PHE13J, PHE161J, PHE162I, PHE172J, PHE193J, PHE201I, PHE203I, PHE254I, PHE35J, PHE83J, PHE84I, PHE88J, PHE92J, PHE96J, PRO107I, PRO120J, PRO126J, PRO132J, PRO145I, PRO163J, PRO165I, PRO167J, PRO190I, PRO199J, PRO219J, PRO220I, PRO255I, PRO259I, PRO90I, PRO91J, PRO92I, SER109I, SER122J, SER127J, SER143J, SER172I, SER182I, SER197J, SER211I, SER252I, SER83I, THR117J, THR163I, THR167I, THR173I, THR176J, THR184J, THR196J, THR239I, THR243I, THR246J, THR250I, THR253I, THR257I, THR25J, THR26J, THR97I, TRP106J, TRP114J, TRP116J, TRP132I, TRP135J, TRP166J, TRP187I, TRP191I, TRP198I, TRP202I, TRP28J, TRP53J, TRP56J, TRP59J, TRP65J, TRP84J, TRP85J, TYR110J, TYR118J, TYR162J, TYR179I, TYR185I, TYR201J, TYR212I, TYR247I, VAL110I, VAL124J, VAL131J, VAL134I, VAL138J, VAL140I, VAL152J, VAL166I, VAL174I, VAL194I, VAL194J, VAL205J, VAL213I, VAL215I, VAL217J, VAL218J, VAL223I, VAL235I, VAL23J, VAL245I, VAL249I, VAL32J, VAL57J, VAL82I, VAL86J, VAL93I, VAL95I, VAL95J, VAL98J
• B-F: ARG211F, ARG241F, ARG89F, ASN87F, GLN251B, GLY144F, ILE148F, ILE202B, ILE249B, ILE252B, LEU140F, PHE234F, PHE238F, PRO199B, SER143F, SER145F, SER197B, THR149F, TRP237F, TRP85F, TYR146F, TYR201B, VAL147F, VAL86F
• B-C: ALA117C, ALA122C, ALA131C, ALA176C, ALA182C, ALA19B, ALA20B, ALA228C, ALA244C, ALA24B, ALA252C, ALA37B, ALA78B, ALA79B, ALA82B, ALA96C, ALA97B, ARG102C, ARG109B, ARG138C, ARG195B, ARG241B, ARG241C, ARG248B, ARG39C, ARG98C, ASN108B, ASN112B, ASN14B, ASN196C, ASN87B, ASP129C, ASP20C, ASP27B, ASP52B, ASP54B, CYS22B, GLN109C, GLN128C, GLN237C, GLN251B, GLN43C, GLN81B, GLU100C, GLU105B, GLU127C, GLU149C, GLU16C, GLU18B, GLU249C, GLU250B, GLU42C, GLU99C, GLY100B, GLY104B, GLY115B, GLY115C, GLY11B, GLY121C, GLY130C, GLY178C, GLY21B, GLY225C, GLY230C, GLY233C, GLY240B, GLY240C, GLY247C, GLY40B, GLY41B, GLY46C, GLY50C, GLY51B, GLY93B, HIS133C, HIS146C, HIS177C, HIS43B, HIS45B, ILE103B, ILE107B, ILE116C, ILE118C, ILE137C, ILE148C, ILE185C, ILE188C, ILE193C, ILE194C, ILE202B, ILE238C, ILE242C, ILE246C, ILE249B, ILE252B, LEU101B, LEU104C, LEU107C, LEU111C, LEU123B, LEU181C, LEU184C, LEU21C, LEU229C, LEU235B, LEU236C, LEU239C, LEU245C, LEU28C, LEU30B, LEU31B, LEU33B, LEU34B, LEU36C, LEU39B, LEU48B, LEU51C, LYS169C, LYS247B, LYS248C, MET101C, MET134C, MET198B, MET227C, MET239B, MET24C, MET29B, MET47B, PHE113B, PHE119B, PHE124C, PHE125C, PHE13B, PHE150C, PHE165C, PHE175C, PHE183C, PHE193B, PHE232C, PHE35B, PHE36B, PHE45C, PHE46B, PHE55B, PHE76B, PHE83B, PHE88B, PHE96B, PRO126B, PRO12B, PRO144C, PRO195C, PRO199B, PRO97C, SER123C, SER145C, SER15B, SER17C, SER180C, SER197B, SER244B, SER80B, THR117B, THR126C, THR135C, THR143C, THR196B, THR245B, THR246B, THR25B, THR26B, THR49B, THR75B, TRP106B, TRP110C, TRP114B, TRP116B, TRP120C, TRP132C, TRP226C, TRP236B, TRP237B, TRP242B, TRP25C, TRP28B, TRP47C, TRP56B, TRP59B, TRP62C, TRP84B, TYR110B, TYR114C, TYR118B, TYR119C, TYR154C, TYR157C, TYR174C, TYR179C, TYR243B, TYR41C, TYR42B, VAL105C, VAL106C, VAL108C, VAL111B, VAL112C, VAL113C, VAL124B, VAL136C, VAL16B, VAL186C, VAL18C, VAL194B, VAL19C, VAL231C, VAL234C, VAL235C, VAL23B, VAL251C, VAL32B, VAL38B, VAL44B, VAL44C, VAL86B
• B-K: ALA150B, ALA187K, ARG138K, ARG211B, ARG63B, ASN196K, ASP139K, ASP141K, ASP216B, GLY189K, GLY214B, GLY226B, HIS133K, ILE137K, ILE148B, ILE185K, ILE188K, ILE193K, ILE194K, LEU155B, LEU181K, LEU184K, LEU210B, LEU235B, LEU78K, LYS215B, MET192K, MET230B, MET231B, PHE142K, PHE166K, PHE191K, PHE213B, PHE223B, PHE224B, PHE227B, PHE234B, PHE238B, PHE54K, PRO190K, PRO195K, PRO219B, SER145B, SER154B, SER229B, SER53K, THR140K, THR209B, THR212B, TRP226K, TYR146B, TYR151K, TYR179K, TYR233B, VAL147B, VAL151B, VAL152B, VAL197K, VAL220B, VAL228B, VAL232B
• B-E: GLN251B, PRO220E, VAL215E
• B-I: ALA175B, ALA380I, ALA76I, ALA78I, ARG203B, ARG207B, ARG211B, ARG375I, ARG39I, ARG41I, ARG62B, ARG63B, ASN139I, ASN289I, ASP216B, ASP378I, ASP382I, ASP384I, ASP61B, GLN174B, GLN178B, GLN181B, GLN34I, GLN35I, GLN386I, GLN75I, GLU141I, GLU177B, GLU200B, GLU206B, GLU31I, GLY142I, GLY143I, GLY144I, GLY180B, GLY208B, GLY214B, GLY290I, GLY291I, GLY30I, GLY407I, HIS173B, HIS179B, HIS29I, ILE138I, ILE146I, ILE147I, ILE410I, LEU182B, LEU210B, LEU379I, LEU38I, LEU43I, LYS215B, LYS32I, MET183B, MET204B, MET40I, PHE213B, PHE37I, PHE413I, PRO145I, PRO219B, PRO408I, PRO411I, PRO74I, SER33I, SER385I, THR176B, THR184B, THR209B, THR212B, THR383I, THR42I, TRP73I, TYR201B, TYR293I, TYR381I, VAL140I, VAL205B, VAL217B, VAL218B, VAL220B, VAL292I, VAL295I, VAL409I, VAL77I
• F-C: ALA150F, ALA187C, ARG138C, ARG211F, ARG63F, ASN196C, ASP139C, ASP141C, ASP216F, GLY189C, GLY214F, GLY226F, HIS133C, ILE137C, ILE148F, ILE185C, ILE188C, ILE193C, ILE194C, LEU155F, LEU181C, LEU184C, LEU210F, LEU235F, LEU74C, LEU78C, LYS215F, MET192C, MET230F, MET231F, PHE142C, PHE166C, PHE191C, PHE213F, PHE223F, PHE224F, PHE227F, PHE234F, PHE238F, PHE54C, PRO190C, PRO195C, PRO219F, SER145F, SER154F, SER229F, SER53C, THR140C, THR212F, TRP226C, TYR146F, TYR151C, TYR179C, TYR233F, VAL147F, VAL151F, VAL152F, VAL197C, VAL220F, VAL228F, VAL232F
• F-G: ALA117G, ALA122G, ALA131G, ALA176G, ALA182G, ALA19F, ALA20F, ALA228G, ALA244G, ALA24F, ALA252G, ALA37F, ALA78F, ALA79F, ALA82F, ALA96G, ALA97F, ARG102G, ARG109F, ARG138G, ARG195F, ARG241F, ARG248F, ARG39G, ARG98G, ASN108F, ASN112F, ASN14F, ASN196G, ASN87F, ASP129G, ASP20G, ASP27F, ASP52F, ASP54F, CYS22F, CYS77F, GLN109G, GLN128G, GLN237G, GLN251F, GLN43G, GLN81F, GLU100G, GLU105F, GLU127G, GLU149G, GLU16G, GLU18F, GLU249G, GLU250F, GLU42G, GLU99G, GLY100F, GLY104F, GLY115F, GLY115G, GLY11F, GLY121G, GLY130G, GLY178G, GLY21F, GLY225G, GLY230G, GLY233G, GLY240F, GLY240G, GLY247G, GLY40F, GLY41F, GLY46G, GLY50G, GLY51F, GLY93F, HIS133G, HIS146G, HIS177G, HIS43F, HIS45F, ILE103F, ILE107F, ILE116G, ILE118G, ILE137G, ILE148G, ILE185G, ILE188G, ILE193G, ILE194G, ILE202F, ILE238G, ILE242G, ILE246G, ILE249F, ILE252F, ILE40G, ILE71F, LEU101F, LEU104G, LEU107G, LEU111G, LEU123F, LEU181G, LEU184G, LEU21G, LEU229G, LEU235F, LEU236G, LEU239G, LEU245G, LEU28G, LEU30F, LEU31F, LEU33F, LEU34F, LEU36G, LEU39F, LEU48F, LEU51G, LEU72F, LYS169G, LYS247F, LYS248G, MET101G, MET134G, MET198F, MET227G, MET239F, MET24G, MET29F, MET47F, PHE113F, PHE119F, PHE124G, PHE125G, PHE13F, PHE150G, PHE165G, PHE166G, PHE175G, PHE183G, PHE193F, PHE224G, PHE232G, PHE35F, PHE36F, PHE45G, PHE46F, PHE55F, PHE76F, PHE83F, PHE88F, PHE96F, PRO126F, PRO12F, PRO144G, PRO173G, PRO195G, PRO199F, PRO97G, SER123G, SER145G, SER15F, SER17G, SER180G, SER197F, SER244F, SER80F, THR117F, THR126G, THR135G, THR143G, THR196F, THR245F, THR246F, THR25F, THR26F, THR49F, THR75F, TRP106F, TRP110G, TRP114F, TRP116F, TRP120G, TRP132G, TRP226G, TRP236F, TRP242F, TRP25G, TRP28F, TRP47G, TRP56F, TRP59F, TRP62G, TRP84F, TYR110F, TYR114G, TYR118F, TYR119G, TYR154G, TYR157G, TYR174G, TYR179G, TYR243F, TYR41G, TYR42F, VAL105G, VAL106G, VAL108G, VAL111F, VAL112G, VAL113G, VAL124F, VAL136G, VAL16F, VAL186G, VAL18G, VAL194F, VAL19G, VAL231G, VAL232F, VAL234G, VAL235G, VAL23F, VAL251G, VAL32F, VAL38F, VAL44F, VAL44G, VAL86F
• F-E: ALA106E, ALA128F, ALA133F, ALA168F, ALA170F, ALA171F, ALA175F, ALA186E, ALA186F, ALA193E, ALA196E, ALA197E, ALA19F, ALA210E, ALA216E, ALA233E, ALA237E, ALA242E, ALA248E, ALA24F, ALA262E, ALA87E, ALA94F, ALA97F, ALA98E, ARG108E, ARG109F, ARG125E, ARG127E, ARG128E, ARG183E, ARG195F, ARG203F, ARG205E, ARG207F, ARG214E, ARG219E, ARG229E, ARG230E, ARG256E, ARG62F, ARG63F, ARG89F, ARG96E, ASN123E, ASN139E, ASN164F, ASN165F, ASN178E, ASN251E, ASN86E, ASN87F, ASP137F, ASP164E, ASP170E, ASP175E, ASP187F, ASP221E, ASP222E, ASP226E, ASP227E, ASP228E, ASP27F, ASP54F, ASP58F, ASP61F, CYS22F, GLN104E, GLN137E, GLN174F, GLN178F, GLN181F, GLN261E, GLN265E, GLN99E, GLU105F, GLU141E, GLU177E, GLU177F, GLU200F, GLU206F, GLU89E, GLY100F, GLY104F, GLY115F, GLY142E, GLY143E, GLY144E, GLY144F, GLY156F, GLY171E, GLY180E, GLY180F, GLY190F, GLY195E, GLY207E, GLY208F, GLY218E, GLY225E, GLY232E, GLY246E, GLY263E, GLY88E, GLY91E, GLY93F, HIS135E, HIS173F, HIS179F, HIS188E, HIS192F, HIS29E, ILE103F, ILE107F, ILE121F, ILE122E, ILE130F, ILE134F, ILE138E, ILE139F, ILE147E, ILE169F, ILE181E, ILE184E, ILE189F, ILE199E, ILE202F, ILE204E, ILE208E, ILE209E, ILE224E, ILE231E, ILE234E, ILE240E, ILE244E, ILE258E, LEU101F, LEU123F, LEU124E, LEU136F, LEU140F, LEU141F, LEU142F, LEU159F, LEU160F, LEU168E, LEU169E, LEU176E, LEU182F, LEU185F, LEU188F, LEU189E, LEU191F, LEU192E, LEU200E, LEU236E, LEU238E, LEU260E, LEU264E, LEU30F, LEU31F, LEU33F, LEU34F, LEU85E, LEU90F, LEU94E, LEU99F, LYS160E, LYS206E, LYS60F, MET102F, MET129F, MET159E, MET183F, MET198F, MET204F, MET29F, MET64F, PHE100E, PHE105E, PHE113F, PHE119F, PHE125F, PHE13F, PHE161F, PHE162E, PHE172F, PHE193F, PHE201E, PHE203E, PHE254E, PHE35F, PHE83F, PHE84E, PHE88F, PHE92F, PHE96F, PRO107E, PRO120F, PRO126F, PRO132F, PRO145E, PRO163F, PRO165E, PRO167F, PRO190E, PRO199F, PRO219F, PRO220E, PRO255E, PRO259E, PRO90E, PRO91F, PRO92E, SER109E, SER122F, SER127F, SER143F, SER172E, SER182E, SER197F, SER211E, SER252E, SER83E, THR117F, THR163E, THR167E, THR173E, THR176F, THR184F, THR196F, THR239E, THR243E, THR246F, THR250E, THR253E, THR257E, THR25F, THR26F, THR97E, TRP106F, TRP114F, TRP116F, TRP132E, TRP135F, TRP166F, TRP187E, TRP191E, TRP198E, TRP202E, TRP28F, TRP53F, TRP56F, TRP59F, TRP65F, TRP84F, TRP85F, TYR110F, TYR118F, TYR162F, TYR179E, TYR185E, TYR201F, TYR212E, TYR247E, VAL110E, VAL124F, VAL131F, VAL134E, VAL138F, VAL140E, VAL166E, VAL174E, VAL194E, VAL194F, VAL205F, VAL213E, VAL215E, VAL217F, VAL218F, VAL223E, VAL235E, VAL23F, VAL245E, VAL249E, VAL32F, VAL57F, VAL82E, VAL86F, VAL93E, VAL95E, VAL95F, VAL98F
• F-I: GLN251F, PRO220I, VAL215I
• G-E: ALA131G, ALA136E, ALA210E, ALA216E, ALA244G, ALA252G, ALA55G, ALA87E, ARG128E, ARG131E, ARG138G, ARG214E, ARG241G, ARG375E, ARG39E, ARG48G, ASN139E, ASN86E, ASP139G, ASP222E, ASP378E, ASP52G, GLN137E, GLN237G, GLN34E, GLN43G, GLU217E, GLU249G, GLU31E, GLU89E, GLY130E, GLY144E, GLY148E, GLY218E, GLY240G, GLY247G, GLY250G, GLY30E, GLY46G, GLY88E, GLY91E, HIS133E, HIS135E, HIS243G, HIS29E, ILE137G, ILE146E, ILE147E, ILE208E, ILE209E, ILE238G, ILE242G, ILE246G, ILE373E, LEU104G, LEU236G, LEU239G, LEU51G, LYS206E, LYS32E, MET101G, MET134G, PHE54G, PRO145E, PRO90E, PRO92E, SER211E, SER33E, SER53G, THR135G, THR140G, TRP132E, TRP132G, TRP152E, TRP47G, TYR212E, VAL105G, VAL108G, VAL136G, VAL213E, VAL215E, VAL235G, VAL251G, VAL93E
• K-I: ALA131K, ALA136I, ALA210I, ALA216I, ALA244K, ALA252K, ALA55K, ALA87I, ARG128I, ARG131I, ARG138K, ARG214I, ARG241K, ARG375I, ARG39I, ARG48K, ASN139I, ASN86I, ASP139K, ASP378I, ASP52K, GLN137I, GLN237K, GLN34I, GLN43K, GLU217I, GLU249K, GLU31I, GLU89I, GLY130I, GLY144I, GLY148I, GLY218I, GLY240K, GLY247K, GLY250K, GLY30I, GLY46K, GLY50K, GLY88I, GLY91I, HIS133I, HIS135I, HIS243K, HIS29I, ILE137K, ILE146I, ILE147I, ILE208I, ILE209I, ILE238K, ILE242K, ILE246K, ILE373I, LEU104K, LEU236K, LEU239K, LEU51K, LYS206I, LYS32I, MET101K, MET134K, PHE54K, PRO145I, PRO56K, PRO90I, PRO92I, SER211I, SER33I, SER53K, THR135K, THR140K, TRP132I, TRP132K, TRP152I, TRP47K, TYR212I, VAL105K, VAL108K, VAL136K, VAL213I, VAL215I, VAL235K, VAL251K, VAL93I
• E-I: ALA262I, ALA380E, ALA72E, ALA76E, ALA78E, ARG108I, ARG256I, ARG41E, ARG81I, ASN289E, ASN79E, ASP170I, ASP382E, ASP384E, GLN104I, GLN261I, GLN265I, GLN35E, GLN386E, GLN75E, GLU141I, GLU287E, GLU404E, GLY263I, GLY406E, GLY407E, ILE114E, ILE258I, ILE405E, ILE410E, LEU169I, LEU260I, LEU264I, LEU288E, LEU379E, LYS266I, LYS412E, PHE105I, PHE37E, PHE413E, PHE70E, PRO255I, PRO259I, PRO267I, PRO296E, PRO408E, PRO411E, PRO74E, SER109I, SER385E, SER71E, THR257I, THR286E, THR383E, TRP73E, TYR293E, TYR381E, VAL292E, VAL295E, VAL409E, VAL414E, VAL77E, VAL82I