3RCY

crystal structure of mandelate racemase/muconate lactonizing enzyme- like protein from roseovarius sp. tm1035

• Total interactions analyzed: 28
• Total true interactions: 16
• Strongest Interaction:
  • Chains: F-H
  • Int. Res.: 199
  • Norm. En. per Res.: -5.0499
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-36.6802	-12.1522	-233.88	-282.7124	117	11	3	9559	6	16	18
A-C	-137.0255	-162.9491	-686.201	-986.1756	198	31	14	25208	12	60	54
A-D	-117.3732	-79.346	-341.056	-537.7752	121	19	5	13856	13	40	34
A-E	-30.6532	-56.9231	-235.948	-323.5243	118	9	3	9681	6	16	18
B-D	-125.78	-161.5391	-689.535	-976.8541	200	26	15	25272	12	58	54
B-F	-40.3679	-11.9842	-240.098	-292.4501	121	14	3	10007	5	16	18
B-H	-96.8281	-76.3504	-342.823	-516.0015	122	13	5	13748	13	40	34
C-D	-37.1801	-14.2247	-241.115	-292.5198	120	10	3	9937	5	16	18
C-E	-101.4751	-87.5583	-343.144	-532.1775	122	12	5	13827	12	40	34
C-G	-37.8907	-57.3815	-245.441	-340.7133	118	12	3	9888	5	16	18
D-H	-31.652	-14.1224	-239.794	-285.5683	121	14	3	10053	5	16	18
E-F	-45.5036	-58.4453	-234.436	-338.3849	118	12	3	9532	5	16	18
E-G	-150.3906	-165.9385	-687.76	-1004.0891	199	26	14	25267	12	59	55
F-G	-79.0997	-45.3929	-347.208	-471.7007	124	18	5	14504	12	40	34
F-H	-156.1289	-159.3547	-689.445	-1004.9286	199	25	15	25232	12	59	55
G-H	-44.4895	-12.7756	-233.105	-290.3702	117	14	3	9506	5	16	18

Interface residues

• A-B: ALA127A, ALA163A, ALA181B, ALA203A, ALA216B, ALA218B, ALA224B, ALA244B, ALA249A, ALA251B, ALA257A, ALA276A, ALA277A, ALA278A, ALA300A, ALA305A, ALA326A, ALA391B, ARG124A, ARG126A, ARG175B, ARG196A, ARG220B, ARG250A, ARG250B, ARG253A, ARG253B, ARG273A, ASN122A, ASN241B, ASN304A, ASN330A, ASP184B, ASP201A, ASP204A, ASP240B, ASP394B, CYS393B, GLN212B, GLN223B, GLN247B, GLN306A, GLU226A, GLU226B, GLU274A, GLU301A, GLU390B, GLY160A, GLY176B, GLY177B, GLY200A, GLY211B, GLY217B, GLY222B, GLY243B, GLY275A, GLY355A, HIS178B, ILE125A, ILE185B, ILE219B, ILE225B, ILE254A, ILE254B, ILE279A, ILE328A, ILE331A, LEU174B, LEU187B, LEU205A, LEU206A, LEU221B, LEU231A, LEU272A, LEU332A, LYS120A, LYS202A, MET121A, MET179B, MET182B, MET245B, MET299A, MET307A, MET333A, PHE213B, PRO123A, PRO180B, PRO227A, PRO227B, PRO230A, PRO236B, PRO238B, PRO239B, PRO255A, PRO329A, SER186B, SER229A, SER392B, THR162A, THR173B, THR183B, THR214B, THR215B, TRP232A, TYR161A, TYR228A, TYR233A, TYR303A, TYR356A, TYR395B, VAL199A, VAL237B, VAL248B, VAL252A, VAL252B, VAL256A, VAL302A
• A-C: ALA244A, ALA244C, ALA266A, ALA266C, ALA269A, ALA269C, ALA287A, ALA287C, ALA391A, ALA42A, ALA42C, ALA43A, ALA43C, ALA49A, ALA49C, ALA52A, ALA52C, ALA90A, ALA90C, ALA93A, ALA93C, ARG175A, ARG175C, ARG21A, ARG21C, ARG261A, ARG261C, ARG273A, ARG273C, ARG286A, ARG286C, ARG51A, ARG51C, ARG60A, ARG60C, ARG75A, ARG75C, ARG76A, ARG76C, ARG85A, ARG85C, ASN241A, ASN241C, ASN69A, ASN69C, ASP167A, ASP167C, ASP240A, ASP240C, ASP56A, ASP56C, ASP87A, ASP87C, GLN212A, GLN212C, GLN389A, GLN389C, GLN84A, GLN84C, GLU234A, GLU234C, GLU235A, GLU235C, GLU260A, GLU260C, GLU267A, GLU267C, GLU274A, GLU274C, GLU387A, GLU387C, GLU390A, GLU390C, GLU48A, GLU48C, GLU55A, GLU55C, GLU65A, GLU65C, GLU71A, GLU71C, GLY176A, GLY176C, GLY177A, GLY177C, GLY208A, GLY208C, GLY211A, GLY211C, GLY243A, GLY243C, GLY259A, GLY259C, GLY381A, GLY381C, GLY383A, GLY383C, GLY46A, GLY46C, GLY81A, GLY81C, GLY92A, HIS210A, HIS210C, HIS310A, HIS310C, HIS385A, HIS385C, HIS61A, HIS61C, ILE54A, ILE54C, ILE91A, ILE91C, LEU174A, LEU174C, LEU262A, LEU262C, LEU384A, LEU384C, LEU386A, LEU386C, LEU72A, LEU72C, LEU88A, LEU88C, LYS265A, LYS265C, MET388A, MET388C, MET50A, MET50C, MET73A, MET73C, PHE268A, PHE268C, PHE58A, PHE58C, PHE74A, PHE74C, PHE82A, PHE82C, PRO238A, PRO238C, PRO239A, PRO239C, PRO270A, PRO270C, PRO47A, PRO47C, PRO86A, PRO86C, SER44A, SER44C, SER79A, SER79C, SER80A, SER80C, THR173A, THR173C, THR209A, THR209C, THR263A, THR263C, THR264A, THR264C, THR382A, THR382C, THR83A, THR83C, THR89A, THR89C, TYR130A, TYR130C, TYR172A, TYR172C, TYR22A, TYR22C, TYR312A, TYR312C, TYR379A, TYR379C, TYR41A, TYR41C, TYR78A, TYR78C, VAL237A, VAL237C, VAL242A, VAL242C, VAL45A, VAL45C, VAL53A, VAL53C, VAL57A, VAL57C, VAL77A, VAL77C
• A-D: ALA108A, ALA108D, ALA115A, ALA115D, ALA266A, ALA266D, ALA269A, ALA269D, ALA297A, ALA297D, ALA298A, ALA298D, ALA300A, ALA300D, ALA326A, ALA326D, ARG109A, ARG109D, ARG111A, ARG111D, ARG273A, ARG273D, ARG75A, ARG75D, ARG76A, ARG76D, ASN122A, ASN122D, ASN304A, ASN304D, ASN330A, ASN330D, ASN66A, ASN66D, ASN69A, ASN69D, GLN84A, GLN84D, GLU267A, GLU267D, GLU292A, GLU292D, GLU301A, GLU301D, GLU65A, GLU65D, GLU68A, GLU68D, GLU71A, GLU71D, GLY106A, GLY110A, GLY110D, GLY118A, GLY118D, GLY119A, GLY119D, ILE328A, ILE328D, ILE70A, ILE70D, LEU105A, LEU105D, LEU116A, LEU116D, LEU117A, LEU117D, LEU272A, LEU272D, LEU72A, LEU72D, LYS120A, LYS120D, LYS265A, LYS265D, LYS294A, LYS294D, LYS295A, LYS295D, MET121A, MET121D, MET299A, MET299D, MET73A, MET73D, PHE268A, PHE268D, PHE74A, PHE74D, PRO112A, PRO112D, PRO123A, PRO123D, PRO270A, PRO270D, PRO329A, PRO329D, PRO67A, PRO67D, SER327A, SER327D, THR264A, THR264D, TRP102A, TRP102D, TRP114A, TRP114D, TRP291A, TRP291D, TYR303A, TYR303D, TYR78A, TYR78D, VAL113A, VAL113D, VAL1A, VAL1D, VAL296A, VAL296D, VAL302A, VAL302D
• A-E: ALA127E, ALA163E, ALA181A, ALA203E, ALA216A, ALA218A, ALA224A, ALA244A, ALA249E, ALA251A, ALA257E, ALA276E, ALA277E, ALA278E, ALA300E, ALA305E, ALA391A, ARG124E, ARG126E, ARG175A, ARG196E, ARG220A, ARG250A, ARG250E, ARG253A, ARG253E, ARG273E, ASN122E, ASN241A, ASN304E, ASN330E, ASP184A, ASP201E, ASP204E, ASP240A, ASP394A, CYS393A, GLN212A, GLN223A, GLN247A, GLN306E, GLU226A, GLU226E, GLU274E, GLU301E, GLU390A, GLY160E, GLY176A, GLY177A, GLY200E, GLY211A, GLY217A, GLY222A, GLY243A, GLY275E, GLY354E, GLY355E, HIS178A, ILE125E, ILE185A, ILE219A, ILE225A, ILE254A, ILE254E, ILE279E, ILE328E, ILE331E, LEU174A, LEU187A, LEU205E, LEU206E, LEU221A, LEU231E, LEU272E, LEU332E, LYS120E, LYS202E, MET121E, MET179A, MET182A, MET245A, MET299E, MET307E, MET333E, PHE213A, PRO123E, PRO180A, PRO227A, PRO227E, PRO230E, PRO236A, PRO238A, PRO239A, PRO255E, PRO329E, SER186A, SER229E, SER392A, THR162E, THR173A, THR183A, THR214A, THR215A, THR396A, TRP232E, TYR161E, TYR228E, TYR233E, TYR303E, TYR356E, TYR395A, VAL199E, VAL237A, VAL248A, VAL252A, VAL252E, VAL256E, VAL302E
• B-D: ALA244B, ALA244D, ALA266B, ALA266D, ALA269B, ALA269D, ALA287B, ALA287D, ALA391B, ALA391D, ALA42B, ALA42D, ALA43B, ALA43D, ALA49B, ALA49D, ALA52B, ALA52D, ALA90B, ALA90D, ALA93B, ALA93D, ARG175B, ARG175D, ARG21B, ARG21D, ARG261B, ARG261D, ARG273B, ARG273D, ARG286B, ARG286D, ARG51B, ARG51D, ARG60B, ARG60D, ARG75B, ARG75D, ARG76B, ARG76D, ARG85B, ARG85D, ASN241B, ASN241D, ASN69B, ASN69D, ASP167B, ASP167D, ASP240B, ASP240D, ASP56B, ASP56D, ASP87B, ASP87D, GLN212B, GLN212D, GLN389B, GLN389D, GLN84B, GLN84D, GLU234B, GLU234D, GLU235B, GLU235D, GLU260B, GLU260D, GLU267B, GLU267D, GLU274B, GLU274D, GLU387B, GLU387D, GLU390B, GLU390D, GLU48B, GLU48D, GLU55B, GLU55D, GLU65B, GLU65D, GLU71B, GLU71D, GLY176B, GLY176D, GLY177B, GLY177D, GLY208B, GLY208D, GLY211B, GLY211D, GLY243B, GLY243D, GLY259B, GLY259D, GLY381B, GLY381D, GLY383B, GLY383D, GLY46B, GLY46D, GLY81B, GLY81D, GLY92B, HIS210B, HIS210D, HIS310B, HIS310D, HIS385B, HIS385D, HIS61B, HIS61D, ILE54B, ILE54D, ILE91B, ILE91D, LEU174B, LEU174D, LEU262B, LEU262D, LEU384B, LEU384D, LEU386B, LEU386D, LEU72B, LEU72D, LEU88B, LEU88D, LYS265B, LYS265D, MET388B, MET388D, MET50B, MET50D, MET73B, MET73D, PHE213B, PHE268B, PHE268D, PHE58B, PHE58D, PHE74B, PHE74D, PHE82B, PHE82D, PRO238B, PRO238D, PRO239B, PRO239D, PRO270B, PRO270D, PRO47B, PRO47D, PRO86B, PRO86D, SER44B, SER44D, SER79B, SER79D, SER80B, SER80D, THR173B, THR173D, THR209B, THR209D, THR263B, THR263D, THR264B, THR264D, THR382B, THR382D, THR83B, THR83D, THR89B, THR89D, TYR130B, TYR130D, TYR172B, TYR172D, TYR22B, TYR22D, TYR312B, TYR312D, TYR379B, TYR379D, TYR41B, TYR41D, TYR78B, TYR78D, VAL237B, VAL237D, VAL242B, VAL242D, VAL45B, VAL45D, VAL53B, VAL53D, VAL57B, VAL57D, VAL77B, VAL77D
• B-F: ALA163B, ALA181F, ALA203B, ALA216F, ALA218F, ALA224F, ALA244F, ALA249B, ALA251F, ALA257B, ALA276B, ALA277B, ALA278B, ALA300B, ALA305B, ALA325B, ALA326B, ALA391F, ARG124B, ARG126B, ARG175F, ARG196B, ARG220F, ARG250B, ARG250F, ARG253B, ARG253F, ARG273B, ASN122B, ASN241F, ASN304B, ASN330B, ASN397F, ASP184F, ASP201B, ASP204B, ASP240F, ASP394F, CYS393F, GLN212F, GLN223F, GLN247F, GLN306B, GLU226B, GLU226F, GLU274B, GLU301B, GLU390F, GLY160B, GLY176F, GLY177F, GLY200B, GLY211F, GLY217F, GLY222F, GLY243F, GLY275B, GLY354B, GLY355B, HIS178F, ILE125B, ILE185F, ILE219F, ILE225F, ILE254B, ILE254F, ILE279B, ILE328B, ILE331B, LEU174F, LEU187F, LEU205B, LEU206B, LEU221F, LEU231B, LEU272B, LEU332B, LYS120B, LYS202B, MET121B, MET179F, MET182F, MET245F, MET299B, MET307B, MET333B, PHE213F, PRO123B, PRO180F, PRO227B, PRO227F, PRO230B, PRO236F, PRO238F, PRO239F, PRO255B, PRO329B, SER186F, SER229B, SER392F, THR162B, THR173F, THR183F, THR214F, THR215F, THR396F, TRP232B, TYR161B, TYR228B, TYR233B, TYR303B, TYR356B, TYR395F, VAL199B, VAL237F, VAL248F, VAL252B, VAL252F, VAL256B, VAL271B, VAL302B
• B-H: ALA108B, ALA108H, ALA115B, ALA115H, ALA266B, ALA266H, ALA269B, ALA269H, ALA297B, ALA297H, ALA298B, ALA298H, ALA300B, ALA300H, ALA326B, ALA326H, ARG109B, ARG109H, ARG111B, ARG111H, ARG273B, ARG273H, ARG75B, ARG75H, ARG76B, ARG76H, ASN122B, ASN122H, ASN304B, ASN304H, ASN330B, ASN330H, ASN66B, ASN66H, ASN69B, ASN69H, GLN84B, GLN84H, GLU267B, GLU267H, GLU274B, GLU292B, GLU292H, GLU301B, GLU301H, GLU65B, GLU65H, GLU68B, GLU68H, GLU71B, GLU71H, GLY106H, GLY110B, GLY110H, GLY118B, GLY118H, GLY119B, GLY119H, ILE328B, ILE328H, ILE70B, ILE70H, LEU105B, LEU105H, LEU116B, LEU116H, LEU117B, LEU117H, LEU272B, LEU272H, LEU72B, LEU72H, LYS120B, LYS120H, LYS265B, LYS265H, LYS294B, LYS294H, LYS295B, LYS295H, MET121B, MET121H, MET299B, MET299H, MET73B, MET73H, PHE268B, PHE268H, PHE74B, PHE74H, PRO112B, PRO112H, PRO123B, PRO123H, PRO270B, PRO270H, PRO329B, PRO329H, PRO67B, PRO67H, SER327B, SER327H, THR264B, THR264H, TRP102B, TRP102H, TRP114B, TRP114H, TRP291B, TRP291H, TYR303B, TYR303H, TYR78B, TYR78H, VAL113B, VAL113H, VAL1B, VAL1H, VAL296B, VAL296H, VAL302B, VAL302H
• C-D: ALA163D, ALA181C, ALA203D, ALA216C, ALA218C, ALA224C, ALA244C, ALA249D, ALA251C, ALA257D, ALA276D, ALA277D, ALA278D, ALA300D, ALA305D, ALA325D, ALA326D, ALA391C, ARG124D, ARG126D, ARG175C, ARG196D, ARG220C, ARG250C, ARG250D, ARG253C, ARG253D, ARG273D, ASN122D, ASN241C, ASN304D, ASN330D, ASP184C, ASP201D, ASP204D, ASP240C, ASP394C, CYS393C, GLN212C, GLN223C, GLN247C, GLN306D, GLU226C, GLU226D, GLU274D, GLU301D, GLU353D, GLU390C, GLY160D, GLY176C, GLY177C, GLY200D, GLY211C, GLY217C, GLY222C, GLY243C, GLY275D, GLY354D, GLY355D, HIS178C, ILE125D, ILE185C, ILE219C, ILE225C, ILE254C, ILE254D, ILE279D, ILE328D, ILE331D, LEU174C, LEU187C, LEU205D, LEU206D, LEU221C, LEU231D, LEU272D, LEU332D, LYS120D, LYS202D, MET121D, MET179C, MET182C, MET245C, MET299D, MET307D, MET333D, PHE213C, PRO123D, PRO180C, PRO227C, PRO227D, PRO230D, PRO236C, PRO238C, PRO239C, PRO255D, PRO329D, SER186C, SER229D, SER392C, THR162D, THR173C, THR183C, THR214C, THR215C, THR396C, TRP232D, TYR161D, TYR228D, TYR233D, TYR303D, TYR356D, TYR395C, VAL199D, VAL237C, VAL248C, VAL252C, VAL252D, VAL256D, VAL302D
• C-E: ALA108C, ALA108E, ALA115C, ALA115E, ALA266C, ALA266E, ALA269C, ALA269E, ALA297C, ALA297E, ALA298C, ALA298E, ALA300C, ALA300E, ALA326C, ALA326E, ARG109C, ARG109E, ARG111C, ARG111E, ARG273C, ARG273E, ARG75C, ARG75E, ARG76C, ARG76E, ASN122C, ASN122E, ASN304C, ASN304E, ASN330C, ASN330E, ASN66C, ASN66E, ASN69C, ASN69E, GLN84C, GLN84E, GLU267C, GLU267E, GLU274C, GLU292C, GLU292E, GLU301C, GLU301E, GLU65C, GLU65E, GLU68C, GLU68E, GLU71C, GLU71E, GLY106E, GLY110C, GLY110E, GLY118C, GLY118E, GLY119C, GLY119E, ILE328C, ILE328E, ILE70C, ILE70E, LEU105C, LEU105E, LEU116C, LEU116E, LEU117C, LEU117E, LEU272C, LEU272E, LEU72C, LEU72E, LYS120C, LYS120E, LYS265C, LYS265E, LYS294C, LYS294E, LYS295C, LYS295E, MET121C, MET121E, MET299C, MET299E, MET73C, MET73E, PHE268C, PHE268E, PHE74C, PHE74E, PRO112C, PRO112E, PRO123C, PRO123E, PRO270C, PRO270E, PRO329C, PRO329E, PRO67C, PRO67E, SER327C, SER327E, THR264C, THR264E, TRP102C, TRP102E, TRP114C, TRP114E, TRP291C, TRP291E, TYR303C, TYR303E, TYR78C, TYR78E, VAL113C, VAL113E, VAL1C, VAL1E, VAL296C, VAL296E, VAL302C, VAL302E
• C-G: ALA163C, ALA181G, ALA203C, ALA216G, ALA218G, ALA224G, ALA244G, ALA249C, ALA251G, ALA257C, ALA276C, ALA277C, ALA278C, ALA300C, ALA305C, ALA326C, ALA391G, ARG124C, ARG126C, ARG175G, ARG196C, ARG220G, ARG250C, ARG250G, ARG253C, ARG253G, ARG273C, ASN122C, ASN241G, ASN304C, ASN330C, ASP184G, ASP201C, ASP204C, ASP240G, ASP394G, CYS393G, GLN212G, GLN223G, GLN247G, GLN306C, GLU226C, GLU226G, GLU274C, GLU301C, GLU390G, GLY160C, GLY176G, GLY177G, GLY200C, GLY211G, GLY217G, GLY222G, GLY243G, GLY275C, GLY354C, GLY355C, HIS178G, ILE125C, ILE185G, ILE219G, ILE225G, ILE254C, ILE254G, ILE279C, ILE328C, ILE331C, LEU174G, LEU187G, LEU205C, LEU206C, LEU221G, LEU231C, LEU272C, LEU332C, LYS120C, LYS202C, MET121C, MET179G, MET182G, MET245G, MET299C, MET307C, MET333C, PHE213G, PRO123C, PRO180G, PRO227C, PRO227G, PRO230C, PRO236G, PRO238G, PRO239G, PRO255C, PRO329C, SER186G, SER229C, SER392G, THR162C, THR173G, THR183G, THR214G, THR215G, THR396G, TRP232C, TYR161C, TYR228C, TYR233C, TYR303C, TYR356C, TYR395G, VAL199C, VAL237G, VAL248G, VAL252C, VAL252G, VAL256C, VAL302C
• D-H: ALA127H, ALA163H, ALA181D, ALA203H, ALA216D, ALA218D, ALA224D, ALA244D, ALA249H, ALA251D, ALA257H, ALA276H, ALA277H, ALA278H, ALA300H, ALA305H, ALA325H, ALA326H, ALA391D, ARG124H, ARG126H, ARG175D, ARG196H, ARG220D, ARG250D, ARG250H, ARG253D, ARG253H, ARG273H, ASN122H, ASN241D, ASN304H, ASN330H, ASP184D, ASP201H, ASP204H, ASP240D, ASP394D, CYS393D, GLN212D, GLN223D, GLN247D, GLN306H, GLU226D, GLU226H, GLU274H, GLU301H, GLU390D, GLY160H, GLY176D, GLY177D, GLY200H, GLY211D, GLY217D, GLY222D, GLY243D, GLY275H, GLY354H, GLY355H, HIS178D, ILE125H, ILE185D, ILE219D, ILE225D, ILE254D, ILE254H, ILE279H, ILE328H, ILE331H, LEU174D, LEU187D, LEU205H, LEU206H, LEU221D, LEU231H, LEU272H, LEU332H, LYS120H, LYS202H, MET121H, MET179D, MET182D, MET245D, MET299H, MET307H, MET333H, PHE213D, PRO123H, PRO180D, PRO227D, PRO227H, PRO230H, PRO236D, PRO238D, PRO239D, PRO255H, PRO329H, SER186D, SER229H, SER392D, THR162H, THR173D, THR183D, THR214D, THR215D, THR396D, TRP232H, TYR161H, TYR228H, TYR233H, TYR303H, TYR356H, TYR395D, VAL199H, VAL237D, VAL248D, VAL252D, VAL252H, VAL256H, VAL271H, VAL302H
• E-F: ALA127F, ALA163F, ALA181E, ALA203F, ALA216E, ALA218E, ALA224E, ALA244E, ALA249F, ALA251E, ALA257F, ALA276F, ALA277F, ALA278F, ALA300F, ALA305F, ALA325F, ALA326F, ALA391E, ARG124F, ARG126F, ARG175E, ARG196F, ARG220E, ARG250E, ARG250F, ARG253E, ARG253F, ARG273F, ASN122F, ASN241E, ASN304F, ASN330F, ASP184E, ASP201F, ASP204F, ASP240E, ASP394E, CYS393E, GLN212E, GLN223E, GLN247E, GLN306F, GLU226E, GLU226F, GLU274F, GLU301F, GLU390E, GLY160F, GLY176E, GLY177E, GLY200F, GLY211E, GLY217E, GLY222E, GLY243E, GLY275F, GLY355F, HIS178E, ILE125F, ILE185E, ILE219E, ILE225E, ILE254E, ILE254F, ILE279F, ILE328F, ILE331F, LEU174E, LEU187E, LEU205F, LEU206F, LEU221E, LEU231F, LEU272F, LEU332F, LYS120F, LYS202F, MET121F, MET179E, MET182E, MET245E, MET299F, MET307F, MET333F, PHE213E, PRO123F, PRO180E, PRO227E, PRO227F, PRO230F, PRO236E, PRO238E, PRO239E, PRO255F, PRO329F, SER186E, SER229F, SER392E, THR162F, THR173E, THR183E, THR214E, THR215E, TRP232F, TYR161F, TYR228F, TYR233F, TYR303F, TYR356F, TYR395E, VAL199F, VAL237E, VAL248E, VAL252E, VAL252F, VAL256F, VAL302F
• E-G: ALA244E, ALA244G, ALA266E, ALA266G, ALA269E, ALA269G, ALA287E, ALA287G, ALA391E, ALA391G, ALA42E, ALA42G, ALA43E, ALA43G, ALA49E, ALA49G, ALA52E, ALA52G, ALA90E, ALA90G, ALA93E, ALA93G, ARG175E, ARG175G, ARG21E, ARG21G, ARG261E, ARG261G, ARG273E, ARG273G, ARG286E, ARG286G, ARG51E, ARG51G, ARG60E, ARG60G, ARG75E, ARG75G, ARG76E, ARG76G, ARG85E, ARG85G, ASN241E, ASN241G, ASN69E, ASN69G, ASP167E, ASP167G, ASP240E, ASP240G, ASP56E, ASP56G, ASP87E, ASP87G, GLN212E, GLN212G, GLN247E, GLN389E, GLN389G, GLN84E, GLN84G, GLU234E, GLU234G, GLU235E, GLU235G, GLU260E, GLU260G, GLU267E, GLU267G, GLU274E, GLU274G, GLU387E, GLU387G, GLU390E, GLU390G, GLU48E, GLU48G, GLU55E, GLU55G, GLU65E, GLU65G, GLU71E, GLU71G, GLY176E, GLY176G, GLY177E, GLY177G, GLY208E, GLY208G, GLY211E, GLY211G, GLY243E, GLY243G, GLY259E, GLY259G, GLY381E, GLY381G, GLY383E, GLY383G, GLY46E, GLY46G, GLY81E, GLY81G, HIS210E, HIS210G, HIS310E, HIS310G, HIS385E, HIS385G, HIS61E, HIS61G, ILE54E, ILE54G, ILE91E, ILE91G, LEU174E, LEU174G, LEU262E, LEU262G, LEU384E, LEU384G, LEU386E, LEU386G, LEU72E, LEU72G, LEU88E, LEU88G, LYS265E, LYS265G, MET388E, MET388G, MET50E, MET50G, MET73E, MET73G, PHE268E, PHE268G, PHE58E, PHE58G, PHE74E, PHE74G, PHE82E, PHE82G, PRO238E, PRO238G, PRO239E, PRO239G, PRO270E, PRO270G, PRO47E, PRO47G, PRO86E, PRO86G, SER44E, SER44G, SER79E, SER79G, SER80E, SER80G, THR173E, THR173G, THR209E, THR209G, THR263E, THR263G, THR264E, THR264G, THR382E, THR382G, THR83E, THR83G, THR89E, THR89G, TYR130E, TYR130G, TYR172E, TYR172G, TYR22E, TYR22G, TYR312E, TYR312G, TYR379E, TYR379G, TYR41E, TYR41G, TYR78E, TYR78G, VAL237E, VAL237G, VAL242E, VAL242G, VAL45E, VAL45G, VAL53E, VAL53G, VAL57E, VAL57G, VAL77E, VAL77G
• F-G: ALA108F, ALA108G, ALA115F, ALA115G, ALA266F, ALA266G, ALA269F, ALA269G, ALA297F, ALA297G, ALA298F, ALA298G, ALA300F, ALA300G, ALA326F, ALA326G, ARG109F, ARG109G, ARG111F, ARG111G, ARG273F, ARG273G, ARG75F, ARG75G, ARG76F, ARG76G, ASN122F, ASN122G, ASN304F, ASN304G, ASN330F, ASN330G, ASN66F, ASN66G, ASN69F, ASN69G, GLN84F, GLN84G, GLU267F, GLU267G, GLU274F, GLU274G, GLU292F, GLU292G, GLU301F, GLU301G, GLU65F, GLU65G, GLU68F, GLU68G, GLU71F, GLU71G, GLY106F, GLY106G, GLY110F, GLY110G, GLY118F, GLY118G, GLY119F, GLY119G, ILE328F, ILE328G, ILE70F, ILE70G, LEU105F, LEU105G, LEU116F, LEU116G, LEU117F, LEU117G, LEU272F, LEU272G, LEU72F, LEU72G, LYS120F, LYS120G, LYS265F, LYS265G, LYS294F, LYS294G, LYS295F, LYS295G, MET121F, MET121G, MET299F, MET299G, MET73F, MET73G, PHE268F, PHE268G, PHE74F, PHE74G, PRO112F, PRO112G, PRO123F, PRO123G, PRO270F, PRO270G, PRO329F, PRO329G, PRO67F, PRO67G, SER327F, SER327G, THR264F, THR264G, TRP102F, TRP102G, TRP114F, TRP114G, TRP291F, TRP291G, TYR303F, TYR303G, TYR78F, TYR78G, VAL113F, VAL113G, VAL1F, VAL1G, VAL296F, VAL296G, VAL302F, VAL302G
• F-H: ALA244F, ALA244H, ALA266F, ALA266H, ALA269F, ALA269H, ALA287F, ALA287H, ALA391F, ALA391H, ALA42F, ALA42H, ALA43F, ALA43H, ALA49F, ALA49H, ALA52F, ALA52H, ALA90F, ALA90H, ALA93F, ALA93H, ARG175F, ARG175H, ARG21F, ARG21H, ARG261F, ARG261H, ARG273F, ARG273H, ARG286F, ARG286H, ARG51F, ARG51H, ARG60F, ARG60H, ARG75F, ARG75H, ARG76F, ARG76H, ARG85F, ARG85H, ASN241F, ASN241H, ASN69F, ASN69H, ASP167F, ASP167H, ASP240F, ASP240H, ASP56F, ASP56H, ASP87F, ASP87H, GLN212F, GLN212H, GLN247H, GLN389F, GLN389H, GLN84F, GLN84H, GLU234F, GLU234H, GLU235F, GLU235H, GLU260F, GLU260H, GLU267F, GLU267H, GLU274F, GLU274H, GLU387F, GLU387H, GLU390F, GLU390H, GLU48F, GLU48H, GLU55F, GLU55H, GLU65F, GLU65H, GLU71F, GLU71H, GLY176F, GLY176H, GLY177F, GLY177H, GLY208F, GLY208H, GLY211F, GLY211H, GLY243F, GLY243H, GLY259F, GLY259H, GLY381F, GLY383F, GLY383H, GLY46F, GLY46H, GLY81F, GLY81H, GLY92F, HIS210F, HIS210H, HIS310F, HIS310H, HIS385F, HIS385H, HIS61F, HIS61H, ILE54F, ILE54H, ILE91F, ILE91H, LEU174F, LEU174H, LEU262F, LEU262H, LEU384F, LEU384H, LEU386F, LEU386H, LEU72F, LEU72H, LEU88F, LEU88H, LYS265F, LYS265H, MET388F, MET388H, MET50F, MET50H, MET73F, MET73H, PHE268F, PHE268H, PHE58F, PHE58H, PHE74F, PHE74H, PHE82F, PHE82H, PRO238F, PRO238H, PRO239F, PRO239H, PRO270F, PRO270H, PRO47F, PRO47H, PRO86F, PRO86H, SER44F, SER44H, SER79F, SER79H, SER80F, SER80H, THR173F, THR173H, THR209F, THR209H, THR263F, THR263H, THR264F, THR264H, THR382F, THR382H, THR83F, THR83H, THR89F, THR89H, TYR130F, TYR130H, TYR172F, TYR172H, TYR22F, TYR22H, TYR312F, TYR312H, TYR379F, TYR379H, TYR41F, TYR41H, TYR78F, TYR78H, VAL237F, VAL237H, VAL242F, VAL242H, VAL45F, VAL45H, VAL53F, VAL53H, VAL57F, VAL57H, VAL77F, VAL77H
• G-H: ALA127G, ALA163G, ALA181H, ALA203G, ALA216H, ALA218H, ALA224H, ALA244H, ALA249G, ALA251H, ALA257G, ALA276G, ALA277G, ALA278G, ALA300G, ALA305G, ALA326G, ALA391H, ARG124G, ARG126G, ARG175H, ARG196G, ARG220H, ARG250G, ARG250H, ARG253G, ARG253H, ARG273G, ASN122G, ASN241H, ASN304G, ASN330G, ASP184H, ASP201G, ASP204G, ASP240H, ASP394H, CYS393H, GLN212H, GLN223H, GLN247H, GLN306G, GLU226G, GLU226H, GLU274G, GLU301G, GLU390H, GLY160G, GLY176H, GLY177H, GLY200G, GLY211H, GLY217H, GLY222H, GLY243H, GLY275G, GLY355G, HIS178H, ILE125G, ILE185H, ILE219H, ILE225H, ILE254G, ILE254H, ILE279G, ILE328G, ILE331G, LEU174H, LEU187H, LEU205G, LEU206G, LEU221H, LEU231G, LEU272G, LEU332G, LYS120G, LYS202G, MET121G, MET179H, MET182H, MET245H, MET299G, MET307G, MET333G, PHE213H, PRO123G, PRO180H, PRO227G, PRO227H, PRO230G, PRO236H, PRO238H, PRO239H, PRO255G, PRO329G, SER186H, SER229G, SER392H, THR162G, THR173H, THR183H, THR214H, THR215H, TRP232G, TYR161G, TYR228G, TYR233G, TYR303G, TYR356G, TYR395H, VAL199G, VAL237H, VAL248H, VAL252G, VAL252H, VAL256G, VAL302G