3RCC

crystal structure of the streptococcus agalactiae sortase a

• Total interactions analyzed: 153
• Total true interactions: 31
• Strongest Interaction:
  • Chains: D-I
  • Int. Res.: 69
  • Norm. En. per Res.: -2.1749
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	57.2067	-82.8537	-25.647	61	4	1	3408	1	17	23
A-F	-6.0031	54.4809	-100.701	-52.2231	60	3	2	3911	1	20	24
A-K	0.0	1.0733	-13.422	-12.3488	19	0	1	768	0	5	11
A-L	-36.6834	54.6256	-165.72	-147.7778	69	7	1	6561	9	50	45
B-C	0.0	46.9954	-93.8696	-46.8742	60	6	1	3874	1	17	22
B-J	0.0	-4.8717	-13.7361	-18.6078	19	0	1	828	0	8	11
B-K	-18.9241	35.6921	-153.075	-136.307	73	5	1	6603	10	56	49
C-D	0.0	59.2149	-95.553	-36.3381	61	2	1	3631	1	20	19
C-I	0.0	0.0	-14.5488	-14.5488	22	0	1	762	0	6	9
C-J	-20.5419	25.5045	-138.23	-133.2674	70	11	1	6282	8	48	45
D-E	-6.8213	50.9621	-84.9793	-40.8386	57	5	1	3627	1	19	19
D-H	0.0	-3.7973	-12.9935	-16.7908	20	0	1	746	0	6	9
D-I	-42.3165	35.5662	-143.319	-150.0693	69	12	1	6494	6	48	46
E-F	-10.0867	59.9042	-91.8383	-42.0208	64	7	1	3827	1	20	24
E-G	0.0	0.0	-16.2696	-16.2696	22	1	1	856	0	7	11
E-H	-13.3374	59.7665	-150.131	-103.7019	67	4	1	6456	8	51	46
F-G	-31.4265	57.9808	-166.548	-139.9937	68	5	1	6656	8	53	47
F-L	0.0	0.0	-13.4236	-13.4236	17	0	1	808	0	8	10
G-H	0.0	44.3263	-93.539	-49.2127	57	2	1	3601	1	18	23
G-L	-4.5219	59.8348	-73.9908	-18.678	62	7	1	3508	1	19	24
H-I	0.0	50.9924	-85.3563	-34.3639	55	3	1	3540	1	20	22
I-J	-6.5278	55.9724	-87.1793	-37.7346	58	5	1	3613	1	20	20
J-K	-23.1253	26.1892	-62.8126	-59.7487	49	10	1	3077	2	20	19
K-L	-3.591	48.4499	-81.8637	-37.0048	58	4	1	3336	1	19	21
K-R	0.0	0.0	-2.7523	-2.7523	17	0	0	321	0	1	3
M-N	-5.621	46.2345	-76.8696	-36.2561	58	5	1	3471	1	20	24
M-R	-4.7248	40.0258	-64.6339	-29.3329	50	6	1	3157	1	16	17
N-O	-2.8591	52.1681	-94.739	-45.43	60	4	1	3843	2	19	23
O-P	0.0	44.9515	-80.3687	-35.4172	59	4	1	3311	2	19	26
P-Q	-18.2157	55.6521	-100.927	-63.4906	64	7	1	4141	2	20	24
Q-R	-7.3743	48.8041	-90.8913	-49.4614	59	8	1	3703	1	20	19

Interface residues

• A-B: ALA116A, ALA137B, ARG192A, ASN67A, ASN91A, ASP186A, ASP186B, ASP78B, CB8.89520-56.17208, CYS184A, GLU103A, GLU135B, GLU168A, GLU188A, GLU188B, GLU80B, GLU93A, GLY88A, GLY90A, HIS118A, HIS119A, HIS119B, HIS136B, HIS66A, HIS66A5, ILE170A, ILE81B, LEU130B, LEU134B, LEU68A, LEU89A, LEU94A, LYS102A, LYS138B, LYS142B, LYS161B, LYS87A, MET101A, MET141B, PHE121B, PHE131B, PHE86A, PRO133B, PRO164A, PRO187A, PRO69A, PRO77B, SER117A, SER132B, SER95A, THR183A, THR185A, THR185B, THR190A, THR92A, TYR96A, VAL120A, VAL120B, VAL167A, VAL182A, VAL79B
• A-F: ALA116F, ALA137A, ALA189A, ALA189F, ARG192F, ASN67F, ASN82A, ASN91F, ASP186A, ASP186F, ASP78A, CYS184F, GLU103F, GLU135A, GLU168F, GLU188F, GLU191A, GLU80A, GLU93F, GLY88F, GLY90F, HIS118F, HIS119F, HIS136A, HIS66F, ILE170F, ILE81A, LEU115F, LEU130A, LEU134A, LEU68F, LEU89F, LEU94F, LYS102F, LYS138A, LYS142A, LYS161A, LYS87F, MET101F, MET141A, PHE121A, PHE131A, PHE86F, PRO133A, PRO187F, PRO69F, PRO77A, SER117F, SER132A, SER95F, THR183F, THR185A, THR185F, THR190F, THR92F, VAL120A, VAL120F, VAL167F, VAL182F, VAL79A
• A-K: ARG192A, ARG192K, GLU165A, GLU165K, GLU168K, HIS166A, HIS166K, PRO164A, PRO164K, PRO187A, PRO187K, THR163A, THR163K, THR190A, THR190K, VAL167A, VAL167K, VAL169A, VAL169K
• A-L: ALA189A, ARG192A, ARG192L, ASN112A, ASN112L, ASP171A, ASP171L, ASP172A, ASP172L, GLN178A, GLN178L, GLU135A, GLU135L, GLU158A, GLU158L, GLU165A, GLU165L, GLU168A, GLU168L, GLU188L, GLU191A, GLU198A, GLU198L, GLY140A, HIS166A, HIS166L, HIS196A, HIS196L, ILE156A, ILE159A, ILE159L, ILE170A, ILE170L, ILE193A, ILE193L, ILE194A, ILE194L, LEU199L, LYS138A, LYS138L, LYS139A, LYS139L, LYS161A, LYS161L, LYS176A, LYS176L, PRO164A, PRO164L, PRO174A, PRO174L, SER160A, SER160L, THR155A, THR155L, THR157A, THR157L, THR163A, THR163L, THR173A, THR173L, THR180A, THR180L, THR190A, VAL162A, VAL162L, VAL167A, VAL167L, VAL169A, VAL169L
• B-C: ALA114B, ALA116B, ALA137C, ALA189C, ARG192B, ASN67B, ASN91B, ASP186B, ASP186C, ASP78C, CYS184B, GLU103B, GLU135C, GLU168B, GLU188B, GLU80C, GLU93B, GLY140C, GLY88B, GLY90B, HIS118B, HIS119B, HIS119C, HIS136C, HIS66B, ILE170B, ILE81C, LEU115B, LEU130C, LEU134C, LEU68B, LEU89B, LEU94B, LYS102B, LYS138C, LYS142C, LYS161C, LYS87B, MET101B, MET141C, PHE121C, PHE131C, PHE86B, PRO133C, PRO187B, PRO69B, PRO77C, SER117B, SER132C, SER95B, THR100B, THR183B, THR185B, THR185C, THR190C, THR92B, VAL120B, VAL120C, VAL182B, VAL79C
• B-J: ARG192B, ARG192J, CYS184B, GLU165B, GLU165J, GLU168B, GLU168J, GLU188B, HIS166B, HIS166J, PRO164B, PRO164J, PRO187B, THR163B, THR163J, VAL167B, VAL167J, VAL169B, VAL169J
• B-K: ARG192B, ARG192K, ASN112B, ASN112K, ASP171B, ASP171K, ASP172B, ASP172K, GLN178B, GLN178K, GLU135B, GLU135K, GLU158B, GLU158K, GLU165B, GLU165K, GLU168B, GLU168K, GLU188B, GLU191B, GLU191K, GLU198B, GLU198K, GLY175K, HIS166B, HIS166K, HIS196B, HIS196K, ILE156B, ILE156K, ILE159B, ILE159K, ILE170B, ILE170K, ILE193B, ILE193K, ILE194B, ILE194K, LEU199B, LYS138B, LYS138K, LYS139B, LYS139K, LYS161B, LYS161K, LYS176B, LYS176K, PHE131K, PRO164B, PRO164K, PRO174B, PRO174K, SER160B, SER160K, SER177B, SER177K, THR155B, THR155K, THR157B, THR157K, THR163B, THR163K, THR173B, THR173K, THR180B, THR180K, THR190K, VAL162B, VAL162K, VAL167B, VAL167K, VAL169B, VAL169K
• C-D: ALA116C, ALA137D, ALA189C, ARG192C, ASN67C, ASN91C, ASP186C, ASP186D, ASP78D, CYS184C, GLU103C, GLU135D, GLU168C, GLU188C, GLU80D, GLU93C, GLY88C, GLY90C, HIS118C, HIS119C, HIS119D, HIS136D, HIS66C, ILE170C, ILE76D, ILE81D, LEU115C, LEU130D, LEU134D, LEU68C, LEU89C, LEU94C, LYS102C, LYS138D, LYS142D, LYS161D, LYS87C, MET101C, MET141D, PHE121D, PHE131D, PHE86C, PRO133D, PRO164C, PRO187C, PRO69C, PRO77D, SER117C, SER132D, SER95C, THR100C, THR183C, THR185C, THR185D, THR92C, VAL120C, VAL120D, VAL167C, VAL169C, VAL182C, VAL79D
• C-I: ALA189C, ALA189I, ARG192C, ARG192I, GLU165C, GLU165I, GLU168C, GLU168I, GLU188I, HIS166C, HIS166I, PRO164C, PRO164I, PRO187C, PRO187I, THR163C, THR163I, THR190C, THR190I, VAL167C, VAL167I, VAL169C
• C-J: ARG192C, ARG192J, ASN112C, ASN112J, ASP171C, ASP171J, ASP172C, ASP172J, GLN178C, GLN178J, GLU135C, GLU135J, GLU158C, GLU158J, GLU165C, GLU165J, GLU168C, GLU168J, GLU198C, GLU198J, GLY140J, GLY175C, GLY175J, HIS166C, HIS166J, HIS196C, HIS196J, ILE156J, ILE159C, ILE159J, ILE170C, ILE170J, ILE193C, ILE193J, ILE194C, ILE194J, LYS138C, LYS138J, LYS139C, LYS139J, LYS161C, LYS161J, LYS176C, LYS176J, LYS201J, PHE131C, PRO164C, PRO164J, PRO174C, PRO174J, SER160C, SER160J, SER177J, THR155C, THR155J, THR157C, THR157J, THR163C, THR163J, THR173C, THR173J, THR180C, THR180J, THR190C, VAL162C, VAL162J, VAL167C, VAL167J, VAL169C, VAL169J
• D-E: ALA116D, ALA137E, ALA189E, ARG192D, ASN67D, ASN91D, ASP186D, ASP186E, ASP78E, CYS184D, GLU103D, GLU135E, GLU168D, GLU80E, GLU93D, GLY88D, GLY90D, HIS118D, HIS119D, HIS119E, HIS136E, HIS66D, ILE170D, ILE76E, ILE81E, LEU130E, LEU134E, LEU68D, LEU89D, LEU94D, LYS102D, LYS138E, LYS161E, LYS87D, MET101D, MET141E, PHE121E, PHE131E, PHE86D, PRO133E, PRO164D, PRO187D, PRO69D, PRO77E, SER117D, SER132E, SER95D, THR100D, THR183D, THR185D, THR185E, THR92D, VAL120D, VAL120E, VAL167D, VAL182D, VAL79E
• D-H: ARG192D, ARG192H, GLU165D, GLU165H, GLU168D, GLU168H, GLU188H, HIS166D, HIS166H, PRO164D, PRO164H, PRO187D, PRO187H, THR163D, THR163H, THR190H, VAL167D, VAL167H, VAL169D, VAL169H
• D-I: ALA197I, ARG192D, ARG192I, ASN112D, ASN112I, ASP171D, ASP171I, ASP172D, ASP172I, GLN178D, GLN178I, GLU135D, GLU135I, GLU158D, GLU158I, GLU165D, GLU165I, GLU168D, GLU168I, GLU198D, GLU198I, GLU200I, HIS166D, HIS166I, HIS196D, HIS196I, ILE156D, ILE156I, ILE159D, ILE159I, ILE170D, ILE170I, ILE193D, ILE193I, ILE194D, ILE194I, LEU199I, LYS138D, LYS138I, LYS139D, LYS139I, LYS161D, LYS161I, LYS176D, LYS176I, PHE131I, PRO164D, PRO164I, PRO174D, PRO174I, SER160D, SER160I, THR155D, THR155I, THR157D, THR157I, THR163D, THR163I, THR173D, THR173I, THR180D, THR180I, THR190I, VAL162D, VAL162I, VAL167D, VAL167I, VAL169D, VAL169I
• E-F: ALA116E, ALA137F, ALA189E, ALA189F, ARG192E, ASN67E, ASN82F, ASN91E, ASP186E, ASP186F, ASP78F, CYS184E, GLU103E, GLU135F, GLU168E, GLU188E, GLU80F, GLU93E, GLY140F, GLY88E, GLY90E, HIS118E, HIS119E, HIS119F, HIS136F, HIS66E, ILE170E, ILE76F, ILE81F, LEU115E, LEU130F, LEU134F, LEU68E, LEU89E, LEU94E, LYS102E, LYS138F, LYS142F, LYS161F, LYS87E, MET101E, MET141F, PHE121F, PHE131F, PHE86E, PRO133F, PRO164E, PRO187E, PRO69E, PRO77F, SER117E, SER132F, SER95E, THR100E, THR183E, THR185E, THR185F, THR92E, VAL120E, VAL120F, VAL167E, VAL169E, VAL182E, VAL79F
• E-G: ALA189E, ALA189G, ARG192E, ARG192G, GLU165E, GLU165G, GLU168E, GLU168G, GLU188E, HIS166E, HIS166G, PRO164E, PRO164G, PRO187E, PRO187G, THR163E, THR163G, THR190E, THR190G, VAL167E, VAL167G, VAL169E
• E-H: ALA189E, ARG192E, ARG192H, ASN112E, ASN112H, ASP171E, ASP171H, ASP172E, ASP172H, GLN178E, GLN178H, GLU135E, GLU135H, GLU158E, GLU158H, GLU165E, GLU165H, GLU168E, GLU168H, GLU191H, GLU198E, GLU198H, HIS166E, HIS166H, HIS196E, HIS196H, ILE159E, ILE159H, ILE170E, ILE170H, ILE193E, ILE193H, ILE194E, ILE194H, LYS138E, LYS138H, LYS139E, LYS139H, LYS161E, LYS161H, LYS176E, LYS176H, LYS201E, PRO164E, PRO164H, PRO174E, PRO174H, SER160E, SER160H, SER177E, THR155E, THR157E, THR157H, THR163E, THR163H, THR173E, THR173H, THR180E, THR180H, THR190E, THR190H, VAL162E, VAL162H, VAL167E, VAL167H, VAL169E, VAL169H
• F-G: ALA137G, ALA189F, ARG192F, ARG192G, ASN112F, ASN112G, ASP171F, ASP171G, ASP172F, ASP172G, GLN178F, GLN178G, GLU135F, GLU135G, GLU158F, GLU158G, GLU165F, GLU165G, GLU168F, GLU168G, GLU191F, GLU191G, GLU198F, GLU198G, HIS166F, HIS166G, HIS196F, HIS196G, ILE159F, ILE159G, ILE170F, ILE170G, ILE193F, ILE193G, ILE194F, ILE194G, LYS138F, LYS138G, LYS139F, LYS139G, LYS161F, LYS161G, LYS176F, LYS176G, PRO164F, PRO164G, PRO174F, PRO174G, SER160F, SER160G, SER177G, THR155F, THR157F, THR157G, THR163F, THR163G, THR173F, THR173G, THR180F, THR180G, THR190F, THR190G, VAL162F, VAL162G, VAL167F, VAL167G, VAL169F, VAL169G
• F-L: ARG192F, ARG192L, GLU165F, GLU165L, GLU168F, GLU188L, HIS166F, HIS166L, PRO164F, PRO164L, PRO187F, PRO187L, THR163F, THR163L, THR190F, VAL167F, VAL167L
• G-H: ALA116G, ALA137H, ALA189G, ALA189H, ARG192G, ASN67G, ASN91G, ASP186G, ASP186H, ASP78H, CYS184G, GLU103G, GLU135H, GLU168G, GLU188G, GLU80H, GLU93G, GLY88G, GLY90G, HIS118G, HIS119G, HIS136H, HIS66G, ILE170G, ILE76H, ILE81H, LEU115G, LEU130H, LEU134H, LEU68G, LEU89G, LEU94G, LYS102G, LYS138H, LYS161H, LYS87G, MET101G, MET141H, PHE121H, PHE131H, PHE86G, PRO133H, PRO187G, PRO69G, PRO77H, SER117G, SER132H, SER95G, THR183G, THR185G, THR185H, THR92G, VAL120G, VAL120H, VAL167G, VAL182G, VAL79H
• G-L: ALA116L, ALA137G, ALA189G, ARG192L, ASN67L, ASN91L, ASP186G, ASP186L, ASP78G, CYS184L, GLU103L, GLU135G, GLU168L, GLU188L, GLU191G, GLU80G, GLU93L, GLY140G, GLY88L, GLY90L, HIS118L, HIS119G, HIS119L, HIS136G, HIS66L, ILE170L, ILE81G, LEU115L, LEU130G, LEU134G, LEU68L, LEU89L, LEU94L, LYS102L, LYS138G, LYS142G, LYS161G, LYS87L, MET101L, MET141G, PHE121G, PHE131G, PHE86L, PRO133G, PRO164L, PRO187L, PRO69L, PRO77G, SER117L, SER132G, SER95L, THR100L, THR183L, THR185G, THR185L, THR190G, THR92L, VAL120G, VAL120L, VAL167L, VAL182L, VAL79G
• H-I: ALA116H, ALA137I, ALA189H, ALA189I, ARG192H, ASN67H, ASN91H, ASP186H, ASP186I, ASP78I, CYS184H, GLU103H, GLU135I, GLU168H, GLU188H, GLU80I, GLU93H, GLY88H, GLY90H, HIS118H, HIS119H, HIS136I, HIS66H, ILE170H, ILE76I, ILE81I, LEU130I, LEU134I, LEU68H, LEU89H, LEU94H, LYS138I, LYS87H, MET101H, MET141I, PHE121I, PHE131I, PHE86H, PRO133I, PRO187H, PRO69H, PRO77I, SER117H, SER132I, SER95H, THR183H, THR185H, THR185I, THR190I, THR92H, VAL120H, VAL120I, VAL167H, VAL182H, VAL79I
• I-J: ALA116I, ALA137J, ALA189I, ARG192I, ASN67I, ASN91I, ASP186I, ASP78J, CYS184I, GLU103I, GLU135J, GLU168I, GLU188I, GLU80J, GLU93I, GLY88I, GLY90I, HIS118I, HIS119I, HIS119J, HIS136J, HIS66I, ILE170I, ILE76J, ILE81J, LEU115I, LEU130J, LEU134J, LEU68I, LEU89I, LEU94I, LYS102I, LYS138J, LYS161J, LYS87I, MET101I, MET141J, PHE121J, PHE131J, PHE86I, PRO133J, PRO164I, PRO187I, PRO69I, PRO77J, SER117I, SER132J, SER95I, THR183I, THR185I, THR185J, THR92I, VAL120I, VAL120J, VAL167I, VAL169I, VAL182I, VAL79J
• J-K: ALA116J, ALA137K, ARG192J, ASN67J, ASN91J, ASP186J, ASP78K, CYS184J, GLU103J, GLU135K, GLU80K, GLU93J, GLY88J, GLY90J, HIS118J, HIS119J, HIS119K, HIS136K, HIS66J, ILE170J, ILE81K, LEU115J, LEU130K, LEU134K, LEU68J, LEU89J, LEU94J, LYS102J, LYS138K, LYS87J, MET101J, MET141K, PHE121K, PHE131K, PHE86J, PRO133K, PRO69J, PRO77K, SER117J, SER132K, SER95J, THR183J, THR185J, THR92J, VAL120J, VAL120K, VAL167J, VAL182J, VAL79K
• K-L: ALA116K, ALA137L, ARG192K, ASN67K, ASN82L, ASN91K, ASP186K, ASP186L, ASP78L, CYS184K, GLU103K, GLU135L, GLU168K, GLU188K, GLU188L, GLU80L, GLU93K, GLY88K, GLY90K, HIS118K, HIS119K, HIS119L, HIS136L, HIS66K, ILE170K, ILE81L, LEU130L, LEU134L, LEU68K, LEU89K, LEU94K, LYS102K, LYS138L, LYS142L, LYS161L, LYS87K, MET101K, MET141L, PHE121L, PHE131L, PHE86K, PRO133L, PRO164K, PRO187K, PRO69K, PRO77L, SER117K, SER132L, SER95K, THR183K, THR185K, THR185L, THR92K, VAL120K, VAL120L, VAL167K, VAL182K, VAL79L
• K-R: GLU200R, GLY108R, GLY109R, GLY175R, GLY203K, GLY203R, LEU199R, LYS150K, LYS150R, LYS201K, LYS201R, PRO110R, SER149K, SER177R, THR202K, THR202R, VAL151K
• M-N: ALA116M, ALA137N, ALA189N, ARG192M, ASN67M, ASN91M, ASP186M, ASP186N, ASP78N, CYS184M, GLU103M, GLU135N, GLU168M, GLU188M, GLU191N, GLU80N, GLU93M, GLY88M, GLY90M, HIS118M, HIS119M, HIS119N, HIS136N, HIS66M, ILE170M, ILE81N, LEU115M, LEU130N, LEU134N, LEU68M, LEU89M, LEU94M, LYS102M, LYS138N, LYS161N, LYS87M, MET101M, MET141N, PHE121N, PHE131N, PHE86M, PRO133N, PRO164M, PRO187M, PRO69M, PRO77N, SER117M, SER132N, SER95M, THR183M, THR185M, THR185N, THR190N, THR92M, VAL120M, VAL120N, VAL182M, VAL79N
• M-R: ALA116R, ALA137M, ARG192R, ASN67R, ASN91R, ASP186R, ASP78M, CYS184R, GLU103R, GLU135M, GLU168R, GLU80M, GLU93R, GLY88R, GLY90R, HIS118R, HIS119M, HIS119R, HIS136M, HIS66R, ILE170R, ILE81M, LEU115R, LEU130M, LEU134M, LEU68R, LEU89R, LEU94R, LYS102R, LYS138M, LYS161M, LYS87R, MET101R, MET141M, PHE121M, PHE131M, PHE86R, PRO133M, PRO69R, PRO77M, SER117R, SER132M, SER95R, THR183R, THR185R, THR92R, VAL120M, VAL120R, VAL182R, VAL79M
• N-O: ALA116N, ALA137O, ALA189N, ALA189O, ARG192N, ASN67N, ASN91N, ASP186N, ASP186O, ASP78O, CYS184N, GLU103N, GLU135O, GLU168N, GLU188N, GLU80O, GLU93N, GLY140O, GLY88N, GLY90N, HIS118N, HIS119N, HIS119O, HIS136O, HIS66N, ILE170N, ILE81O, LEU115N, LEU130O, LEU134O, LEU68N, LEU89N, LEU94N, LYS102N, LYS138O, LYS142O, LYS161O, LYS87N, MET101N, MET141O, PHE121O, PHE131O, PHE86N, PRO133O, PRO187N, PRO69N, PRO77O, SER117N, SER132O, SER95N, THR100N, THR183N, THR185N, THR185O, THR92N, VAL120N, VAL120O, VAL169N, VAL182N, VAL79O
• O-P: ALA116O, ALA137P, ALA189P, ARG192O, ASN67O, ASN91O, ASP186O, ASP186P, ASP78P, CYS184O, GLU103O, GLU135P, GLU168O, GLU188O, GLU191P, GLU80P, GLU93O, GLY88O, GLY90O, HIS118O, HIS119O, HIS119P, HIS136P, HIS66O, ILE170O, ILE81P, LEU115O, LEU130P, LEU134P, LEU68O, LEU89O, LEU94O, LYS138P, LYS161P, LYS87O, MET101O, MET141P, PHE121P, PHE131P, PHE86O, PRO133P, PRO164O, PRO187O, PRO69O, PRO77P, SER117O, SER132P, SER95O, THR183O, THR185O, THR185P, THR190O, THR190P, THR92O, VAL120O, VAL120P, VAL167O, VAL182O, VAL79P
• P-Q: ALA114P, ALA116P, ALA137Q, ALA189P, ALA189Q, ARG192P, ASN67P, ASN91P, ASP186P, ASP186Q, ASP78Q, CYS184P, GLU103P, GLU135Q, GLU168P, GLU188P, GLU191Q, GLU80Q, GLU93P, GLY140Q, GLY88P, GLY90P, HIS118P, HIS119P, HIS136Q, HIS66P, ILE170P, ILE76Q, ILE81Q, LEU115P, LEU130Q, LEU134Q, LEU68P, LEU89P, LEU94P, LYS102P, LYS138Q, LYS142Q, LYS161Q, LYS87P, MET101P, MET141Q, PHE121Q, PHE131Q, PHE86P, PRO133Q, PRO164P, PRO187P, PRO69P, PRO77Q, SER117P, SER132Q, SER95P, THR100P, THR183P, THR185P, THR185Q, THR92P, VAL120P, VAL120Q, VAL167P, VAL169P, VAL182P, VAL79Q
• Q-R: ALA116Q, ALA137R, ALA189Q, ARG192Q, ASN67Q, ASN91Q, ASP186Q, ASP186R, ASP78R, CYS184Q, GLU103Q, GLU135R, GLU168Q, GLU188Q, GLU80R, GLU93Q, GLY88Q, GLY90Q, GLY99Q, HIS118Q, HIS119Q, HIS136R, HIS66Q, ILE170Q, ILE76R, ILE81R, LEU115Q, LEU130R, LEU134R, LEU68Q, LEU89Q, LEU94Q, LYS102Q, LYS138R, LYS161R, LYS87Q, MET101Q, MET141R, PHE121R, PHE131R, PHE86Q, PRO133R, PRO187Q, PRO69Q, PRO77R, SER117Q, SER132R, SER95Q, THR100Q, THR183Q, THR185Q, THR185R, THR92Q, VAL120Q, VAL120R, VAL167Q, VAL169Q, VAL182Q, VAL79R