3RBQ

co-crystal structure of human unc119 (retina gene 4) and an n-terminal transducin-alpha mimicking peptide

• Total interactions analyzed: 66
• Total true interactions: 18
• Strongest Interaction:
  • Chains: F-L
  • Int. Res.: 60
  • Norm. En. per Res.: -3.3225
• Hub Node: A(6)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	0.0	32.0123	-86.6031	-54.5908	40	4	1	3698	2	8	15
A-C	-21.7497	-11.0529	-65.5341	-98.3368	38	2	0	2846	0	18	15
A-D	-13.7296	13.6773	-116.649	-116.7013	58	4	1	4683	0	19	21
A-F	0.0	0.0	-0.3715	-0.3715	14	0	0	100	0	7	4
A-G	-28.3128	-0.9865	-142.403	-171.7023	57	9	10	5202	0	7	4
A-L	0.0	0.0	-0.0193	-0.0193	2	0	0	2	0	2	5
B-F	0.0	-1.0547	-9.8372	-10.892	13	3	0	541	0	6	4
B-H	-22.5885	-0.1375	-161.844	-184.57	58	12	10	6026	0	15	6
B-L	0.0	9.9624	-5.2427	4.7196	8	0	0	228	0	3	5
C-D	-6.3474	49.8636	-85.6464	-42.1303	40	3	0	3619	2	9	15
C-E	-27.2419	1.8882	-134.228	-159.5817	63	3	1	5108	1	19	23
C-F	-38.6773	-23.9892	-136.555	-199.2215	64	6	3	5467	3	21	21
C-I	-14.4672	0.0	-82.4756	-96.9428	48	5	6	3019	0	0	0
C-L	0.0	0.0	-0.0027	-0.0027	4	0	0	4	0	1	1
D-E	-21.1349	-11.1126	-57.1503	-89.3978	34	1	0	2440	0	15	13
D-J	-14.6141	0.0	-81.3822	-95.9963	50	3	5	2968	0	0	0
E-K	-12.2523	0.0	-61.5049	-73.7572	43	6	4	2322	0	0	0
F-L	-15.9033	-2.6308	-180.817	-199.3511	60	17	11	6543	0	12	10

Interface residues

• A-B: ALA136A, ALA136B, ARG139A, ARG139B, ARG209A, ARG209B, GLU201A, GLU201B, GLU202A, GLU202B, GLU206A, GLU206B, GLY238A, GLY238B, HIS210A, HIS210B, ILE204A, ILE204B, ILE208A, ILE208B, LEU138A, LEU138B, PHE133A, PHE133B, PHE137A, PHE137B, PRO135A, PRO135B, PRO211A, PRO211B, SER205A, SER205B, SER235A, SER235B, SER237A, SER237B, THR134A, THR134B, TYR236A, TYR236B
• A-C: ARG141C, ARG164A, ARG90C, ARG94C, ASP176A, ASP195A, ASP95C, ASP97C, GLN142C, GLN170A, GLN69A, GLU104C, GLU191C, GLU201A, GLY67A, GLY99C, HIS165A, ILE162A, LEU171A, LEU172A, LEU199A, LEU203A, LEU66A, LEU68A, LYS173A, LYS92C, MET96C, PHE175A, PHE196A, PRO197A, PRO198A, SER174A, SER200A, SER98C, THR100C, TYR166A, VAL101C, VAL65A
• A-D: ALA125D, ALA232D, ARG127D, ARG130D, ARG160A, ARG168D, ARG209D, ARG70D, ASN124D, ASN157A, ASN158A, ASN169D, ASN188A, ASP176A, ASP217D, ASP223A, ASP224A, ASP233D, ASP74D, CYS182A, CYS190A, GLN215D, GLU148A, GLU191A, GLU213D, GLU63A, GLY180A, GLY73D, HIS178A, HIS192A, HIS210D, HIS229D, ILE183A, ILE71D, LYS154A, LYS187A, LYS231D, PHE128D, PHE149A, PHE159A, PHE177A, PHE179A, PHE181A, PRO123D, PRO155A, PRO184A, PRO211D, PRO62A, SER185A, SER186A, SER235D, SER237D, THR189A, THR72D, TYR212D, TYR75D, VAL129D, VAL156A
• A-F: ALA136F, ARG168A, ARG209A, ARG70A, GLN69A, GLU104F, GLU202A, GLU206A, GLY238F, ILE105F, LYS106F, PHE103F, THR134F, VAL101F
• A-G: ALA125A, ALA145A, ALA232A, ALA502G, ALA504G, ALA506G, ARG127A, ARG130A, ARG164A, ARG90A, ASN124A, ASN230A, ASN82A, ASP217A, ASP233A, ASP87A, GLU104A, GLU148A, GLU163A, GLU507G, GLY126A, GLY501G, GLY503G, HIS165A, HIS192A, HIS229A, ILE105A, ILE86A, ILE93A, LYS106A, LYS107A, LYS231A, LYS92A, MET161A, MET228A, PHE103A, PHE128A, PHE149A, PHE159A, PHE179A, PHE219A, PHE88A, PHE91A, PRO108A, SER216A, SER218A, SER505G, THR146A, THR150A, TYR131A, TYR194A, TYR220A, TYR234A, TYR75A, VAL129A, VAL147A, VAL89A
• A-L: GLU202A, GLU507L
• B-F: ARG139B, GLU201B, GLU202B, ILE105F, ILE204B, LEU199B, LEU203B, LYS106F, LYS107F, PRO108F, PRO197B, PRO198B, SER200B
• B-H: ALA125B, ALA145B, ALA232B, ALA502H, ALA504H, ALA506H, ARG127B, ARG130B, ARG164B, ARG90B, ASN124B, ASN230B, ASN82B, ASP217B, ASP233B, ASP87B, GLU104B, GLU148B, GLU163B, GLU507H, GLU508H, GLY126B, GLY501H, GLY503H, HIS165B, HIS192B, HIS229B, ILE105B, ILE86B, ILE93B, LYS106B, LYS107B, LYS231B, LYS92B, MET161B, MET228B, PHE103B, PHE128B, PHE149B, PHE159B, PHE179B, PHE219B, PHE88B, PHE91B, PRO108B, PRO79B, SER216B, SER218B, SER505H, THR146B, TYR131B, TYR194B, TYR220B, TYR234B, TYR75B, VAL129B, VAL147B, VAL89B
• B-L: GLU201B, GLU202B, GLU508L, LEU199B, LEU203B, LYS509L, PRO198B, SER200B
• C-D: ALA136C, ALA136D, ARG139C, ARG139D, ARG209C, ARG209D, GLU201C, GLU201D, GLU202C, GLU202D, GLU206C, GLU206D, GLY238C, GLY238D, HIS210C, HIS210D, ILE204C, ILE204D, ILE208C, ILE208D, LEU138C, LEU138D, PHE133C, PHE133D, PHE137C, PHE137D, PRO135C, PRO135D, PRO211C, PRO211D, SER205C, SER205D, SER235C, SER235D, SER237C, SER237D, THR134C, THR134D, TYR236C, TYR236D
• C-E: ALA125C, ALA232C, ARG127C, ARG130C, ARG160E, ARG168C, ARG209C, ARG70C, ASN124C, ASN157E, ASN158E, ASN169C, ASN188E, ASP153E, ASP176E, ASP217C, ASP223E, ASP224E, ASP233C, ASP74C, CYS182E, CYS190E, GLN215C, GLU148E, GLU191E, GLU213C, GLU63E, GLY180E, GLY73C, HIS178E, HIS192E, HIS210C, HIS229C, ILE183E, ILE71C, LEU76C, LYS154E, LYS187E, LYS231C, PHE128C, PHE149E, PHE159E, PHE167C, PHE177E, PHE179E, PHE181E, PRO123C, PRO155E, PRO184E, PRO211C, PRO62E, PRO79C, SER185E, SER186E, SER235C, THR189E, THR214C, THR72C, TYR166C, TYR212C, TYR75C, VAL129C, VAL156E
• C-F: ALA125F, ALA145C, ALA232F, ARG127F, ARG130F, ARG160C, ARG168F, ARG209F, ARG70F, ASN124F, ASN157C, ASN158C, ASN169F, ASN188C, ASP176C, ASP195C, ASP233F, ASP74F, CYS182C, CYS190C, GLN132F, GLN142C, GLN215F, GLU148C, GLU191C, GLU213F, GLY126F, GLY180C, GLY238F, GLY73F, HIS178C, HIS192C, HIS210F, ILE183C, ILE193C, ILE71F, LYS187C, LYS231F, MET96C, PHE128F, PHE149C, PHE159C, PHE177C, PHE179C, PHE181C, PRO123F, PRO155C, PRO184C, PRO211F, SER185C, SER186C, SER216F, SER235F, SER237F, THR146C, THR189C, THR214F, THR72F, TYR212F, TYR234F, TYR75F, VAL129F, VAL147C, VAL156C
• C-I: ALA125C, ALA145C, ALA232C, ALA502I, ALA504I, ARG127C, ARG130C, ARG164C, ARG90C, ASN124C, ASN230C, ASP217C, ASP233C, ASP87C, GLU104C, GLU148C, GLU163C, GLY126C, GLY501I, GLY503I, HIS165C, HIS229C, ILE105C, ILE93C, LYS107C, LYS231C, LYS92C, MET161C, MET228C, PHE103C, PHE128C, PHE149C, PHE159C, PHE179C, PHE219C, PHE88C, PHE91C, SER216C, SER218C, THR146C, TYR131C, TYR194C, TYR220C, TYR234C, TYR75C, VAL129C, VAL147C, VAL89C
• C-L: ALA504L, ILE183C, LYS509L, SER186C
• D-E: ARG141D, ARG164E, ARG90D, ARG94D, ASP176E, ASP195E, ASP95D, ASP97D, GLN142D, GLN170E, GLN69E, GLU104D, GLY67E, GLY99D, HIS165E, ILE162E, LEU171E, LEU172E, LEU66E, LEU68E, LYS106D, LYS173E, LYS92D, MET96D, PHE175E, PHE196E, PRO197E, PRO198E, SER174E, SER98D, THR100D, TYR166E, VAL101D, VAL65E
• D-J: ALA125D, ALA145D, ALA232D, ALA502J, ALA504J, ARG127D, ARG130D, ARG164D, ARG90D, ASN124D, ASN230D, ASP217D, ASP233D, ASP87D, GLU104D, GLU148D, GLU163D, GLY126D, GLY501J, GLY503J, HIS165D, HIS192D, HIS229D, ILE105D, ILE93D, LYS107D, LYS231D, LYS92D, MET161D, MET228D, PHE103D, PHE128D, PHE149D, PHE159D, PHE177D, PHE179D, PHE219D, PHE88D, PHE91D, SER216D, SER218D, THR146D, TYR131D, TYR194D, TYR220D, TYR234D, TYR75D, VAL129D, VAL147D, VAL89D
• E-K: ALA145E, ALA232E, ALA502K, ARG127E, ARG130E, ARG164E, ARG90E, ASN230E, ASP217E, ASP233E, GLU104E, GLU148E, GLU163E, GLY126E, GLY501K, GLY503K, HIS165E, HIS192E, HIS229E, ILE105E, ILE93E, LYS231E, LYS92E, MET161E, MET228E, PHE103E, PHE128E, PHE149E, PHE159E, PHE179E, PHE219E, PHE88E, PHE91E, SER216E, SER218E, THR146E, TYR131E, TYR194E, TYR220E, TYR234E, VAL129E, VAL147E, VAL89E
• F-L: ALA125F, ALA145F, ALA232F, ALA502L, ALA504L, ALA506L, ARG127F, ARG130F, ARG164F, ARG90F, ASN124F, ASN230F, ASN82F, ASP217F, ASP233F, ASP87F, GLU104F, GLU148F, GLU163F, GLU507L, GLU508L, GLY126F, GLY501L, GLY503L, HIS165F, HIS192F, HIS229F, ILE105F, ILE86F, ILE93F, LYS106F, LYS107F, LYS231F, LYS509L, LYS92F, MET161F, MET228F, PHE103F, PHE128F, PHE149F, PHE159F, PHE179F, PHE219F, PHE88F, PHE91F, PRO108F, PRO123F, PRO79F, SER216F, SER218F, SER505L, THR146F, TYR131F, TYR194F, TYR220F, TYR234F, TYR75F, VAL129F, VAL147F, VAL89F