3R6Y

crystal structure of chymotrypsin-treated aspartase from bacillus sp. ym55-1

• Total interactions analyzed: 28
• Total true interactions: 19
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 250
  • Norm. En. per Res.: -4.6973
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-137.5963	-251.5847	-723.829	-1113.0099	250	55	14	30256	27	64	63
A-C	-102.0102	-24.9643	-257.824	-384.7985	102	24	4	9676	4	15	17
A-D	-99.1719	-3.7593	-683.316	-786.2472	276	38	24	30290	0	23	14
A-E	0.0	0.0	-5.9194	-5.9194	14	0	0	427	0	0	0
A-F	0.0	6.1503	-30.8849	-24.7346	47	0	1	2205	0	10	8
B-C	-104.3456	-8.9397	-668.125	-781.4103	236	34	23	27706	1	23	14
B-D	-115.6737	-23.5321	-288.267	-427.4727	104	25	4	10756	4	16	20
B-E	0.0	4.9453	-24.2489	-19.3036	48	1	1	1828	0	10	8
B-F	0.0	1.0514	-6.6243	-5.5729	12	0	1	476	0	1	1
B-H	0.0	-6.4144	-40.4433	-46.8577	25	1	1	1686	0	2	3
C-D	-160.8108	-261.7314	-751.782	-1174.3242	250	50	15	30564	27	65	61
D-F	0.0	-6.7791	-39.6163	-46.3954	23	2	1	1659	0	2	3
D-H	0.0	5.3854	-65.9715	-60.5861	41	2	0	2333	0	0	3
E-F	-139.0037	-258.2365	-683.314	-1080.5542	249	56	13	30215	27	64	64
E-G	-120.0716	-25.9592	-269.916	-415.9468	99	17	3	9698	4	15	17
E-H	-67.9959	-3.0596	-680.648	-751.7035	268	47	25	30295	0	23	14
F-G	-97.6233	-13.5005	-672.827	-783.9508	237	46	23	28187	1	23	14
F-H	-94.0786	-24.0866	-292.27	-410.4352	106	23	2	10858	4	16	18
G-H	-161.6882	-249.0458	-694.347	-1105.081	249	58	14	30564	26	64	62

Interface residues

• A-B: ALA175A, ALA175B, ALA192A, ALA192B, ALA203A, ALA203B, ALA205A, ALA205B, ALA209A, ALA209B, ALA231A, ALA231B, ALA261A, ALA261B, ALA267A, ALA267B, ALA280A, ALA280B, ALA292A, ALA292B, ALA299A, ALA299B, ALA337A, ALA337B, ALA350A, ALA350B, ALA353A, ALA353B, ALA99A, ALA99B, ARG186A, ARG186B, ARG206A, ARG206B, ARG210A, ARG210B, ARG214A, ARG214B, ARG259A, ARG259B, ARG296A, ARG296B, ASN142A, ASN142B, ASN217A, ASN217B, ASN220A, ASN220B, ASN221A, ASN221B, ASN237B, ASN270A, ASN270B, ASN287A, ASN287B, ASN293A, ASN293B, ASN334A, ASN334B, ASN359A, ASN359B, ASP191A, ASP191B, ASP211A, ASP211B, ASP224A, ASP224B, ASP266A, ASP266B, ASP272A, ASP272B, ASP294A, ASP294B, ASP344A, ASP344B, CYS273A, CYS273B, CYS284A, CYS284B, GLN190A, GLN190B, GLN199A, GLN199B, GLN262A, GLN262B, GLN269A, GLN269B, GLN355A, GLN355B, GLU200A, GLU200B, GLU202A, GLU202B, GLU213A, GLU213B, GLU276A, GLU276B, GLU308A, GLU308B, GLU352A, GLU352B, GLU357A, GLU357B, GLY100A, GLY100B, GLY185A, GLY185B, GLY198A, GLY198B, GLY233A, GLY233B, GLY235A, GLY235B, GLY342A, GLY342B, GLY354A, GLY354B, GLY97A, GLY97B, GLY98A, GLY98B, HIS150A, HIS150B, HIS188A, HIS188B, HIS263A, HIS263B, ILE195A, ILE195B, ILE208A, ILE208B, ILE286A, ILE286B, ILE291A, ILE291B, ILE309A, ILE309B, ILE347A, ILE347B, LEU189A, LEU189B, LEU196A, LEU196B, LEU197A, LEU197B, LEU236A, LEU236B, LEU264A, LEU264B, LEU281A, LEU281B, LEU295A, LEU295B, LEU297A, LEU297B, LEU306A, LEU306B, LEU345A, LEU345B, LEU358A, LEU358B, LEU365A, LEU365B, LYS183A, LYS183B, LYS282A, LYS282B, LYS290A, LYS290B, MET172A, MET172B, MET184A, MET184B, MET285A, MET285B, MET288A, MET288B, MET298A, MET298B, MET361A, MET361B, PHE201A, PHE201B, PHE338A, PHE338B, PHE341A, PHE341B, PHE356A, PHE356B, PRO194A, PRO194B, PRO363A, PRO363B, SER140A, SER140B, SER260A, SER260B, SER278A, SER278B, SER279A, SER279B, SER289A, SER289B, SER300A, SER300B, SER349A, SER349B, SER351A, SER351B, THR101A, THR101B, THR141A, THR141B, THR187A, THR187B, THR218A, THR218B, THR230A, THR230B, THR234A, THR234B, THR268A, THR268B, THR271A, THR271B, THR275A, THR275B, THR346A, THR348A, THR348B, TYR204A, TYR204B, TYR274A, TYR274B, VAL193A, VAL193B, VAL207A, VAL207B, VAL232A, VAL232B, VAL265A, VAL265B, VAL277A, VAL277B, VAL283A, VAL283B, VAL340A, VAL340B, VAL360A, VAL360B
• A-C: ALA192A, ALA192C, ALA292A, ALA292C, ALA299A, ALA299C, ALA304A, ALA304C, ALA353A, ALA353C, ARG186A, ARG186C, ARG296A, ARG296C, ARG303A, ARG303C, ASN293A, ASN293C, ASN326A, ASN326C, ASP191A, ASP191C, ASP294A, ASP294C, ASP344A, GLN190A, GLN190C, GLN315A, GLN315C, GLN335A, GLN335C, GLN355A, GLN355C, GLU308A, GLU308C, GLU331A, GLU331C, GLU352A, GLU352C, GLY185A, GLY185C, GLY301A, GLY301C, GLY305A, GLY305C, GLY317C, GLY323A, HIS188A, HIS188C, ILE195C, ILE309A, ILE309C, ILE320A, LEU189A, LEU189C, LEU295A, LEU295C, LEU297A, LEU297C, LEU306A, LEU306C, LEU311A, LEU311C, LEU345A, LEU345C, LYS183A, LYS183C, LYS282A, LYS282C, LYS324A, MET184A, MET184C, MET298A, MET298C, MET321A, MET361A, MET361C, PHE341A, PRO194C, PRO302A, PRO302C, PRO322A, PRO327A, PRO327C, SER300A, SER300C, SER307A, SER307C, SER318A, SER349A, SER349C, THR187A, THR187C, THR348A, THR348C, VAL193C, VAL310A, VAL310C, VAL325A, VAL325C, VAL328A, VAL328C
• A-D: ALA144A, ALA229A, ALA229D, ALA231A, ALA231D, ALA292A, ALA292D, ALA304A, ALA304D, ALA30A, ALA30D, ALA313A, ALA313D, ALA337A, ALA337D, ALA350A, ALA350D, ALA353A, ALA353D, ALA99A, ALA99D, ARG296A, ARG296D, ARG29A, ARG29D, ARG314A, ARG314D, ARG40A, ARG40D, ASN104A, ASN104D, ASN108A, ASN108D, ASN132A, ASN132D, ASN136A, ASN136D, ASN142A, ASN142D, ASN237A, ASN237D, ASN293A, ASN293D, ASN326A, ASN326D, ASN334A, ASN334D, ASN33A, ASN33D, ASN343A, ASN343D, ASN359A, ASN359D, ASN368A, ASN368D, ASN378A, ASN378D, ASN386A, ASN386D, ASP10A, ASP10D, ASP143A, ASP143D, ASP294A, ASP294D, ASP344A, ASP344D, ASP93A, ASP93D, GLN139A, GLN139D, GLN26A, GLN26D, GLN315A, GLN315D, GLN335A, GLN335D, GLN339A, GLN339D, GLN355A, GLN355D, GLN371A, GLN371D, GLN96A, GLN96D, GLU32A, GLU32D, GLU331A, GLU331D, GLU352A, GLU352D, GLU357D, GLU362A, GLU362D, GLU385A, GLU385D, GLY100A, GLY100D, GLY13A, GLY233A, GLY233D, GLY235A, GLY235D, GLY305A, GLY305D, GLY317A, GLY317D, GLY323D, GLY342A, GLY342D, GLY354A, GLY354D, GLY38A, GLY38D, GLY97A, GLY97D, GLY98A, GLY98D, HIS42A, HIS42D, ILE103A, ILE103D, ILE28A, ILE28D, ILE320A, ILE320D, ILE347A, ILE347D, ILE36A, ILE36D, ILE375A, ILE375D, ILE95A, ILE95D, LEU12A, LEU12D, LEU189A, LEU189D, LEU236A, LEU236D, LEU297A, LEU297D, LEU306A, LEU306D, LEU345A, LEU345D, LEU358A, LEU358D, LEU365A, LEU365D, LYS282A, LYS282D, LYS324A, LYS324D, LYS381A, LYS381D, LYS9D, MET105A, MET105D, MET137A, MET137D, MET285D, MET321A, MET321D, MET329A, MET329D, MET333A, MET333D, MET361A, MET361D, MET376A, MET376D, PHE11A, PHE11D, PHE338A, PHE338D, PHE341A, PHE341D, PHE34A, PHE34D, PHE356A, PHE356D, PHE366A, PHE366D, PHE367A, PHE367D, PHE380A, PHE380D, PHE383A, PHE383D, PRO131A, PRO131D, PRO312A, PRO312D, PRO316A, PRO316D, PRO322A, PRO322D, PRO327A, PRO327D, PRO330A, PRO330D, PRO35A, PRO35D, PRO363A, PRO363D, PRO94A, PRO94D, SER102A, SER102D, SER130D, SER133A, SER133D, SER138A, SER138D, SER140A, SER140D, SER289A, SER289D, SER300A, SER300D, SER318A, SER318D, SER319A, SER319D, SER349A, SER349D, SER351A, SER351D, SER374A, SER374D, SER382A, SER382D, THR101A, THR101D, THR141A, THR141D, THR230A, THR230D, THR234D, THR27A, THR27D, THR31A, THR31D, THR346A, THR346D, THR348A, THR348D, THR377A, THR377D, THR37A, THR37D, TYR39A, TYR39D, VAL232A, VAL232D, VAL25A, VAL25D, VAL325A, VAL325D, VAL328A, VAL328D, VAL332A, VAL332D, VAL336A, VAL336D, VAL340A, VAL340D, VAL360A, VAL360D, VAL364A, VAL364D, VAL379A, VAL379D, VAL92A, VAL92D
• A-E: ALA238E, ASN237A, ASN237E, GLY235A, GLY235E, LEU236A, LEU236E, PRO240A, PRO240E, THR234A, THR234E, VAL232A, VAL265A, VAL265E
• A-F: ALA179F, ALA231A, ALA238A, ALA393F, ARG303F, ASN125A, ASN132A, ASN136A, ASN237A, ASN394F, ASN60A, ASP10A, ASP176F, ASP239A, ASP67A, GLN199F, GLU14A, GLU177F, GLY13A, GLY180F, GLY64A, HIS134A, ILE182F, ILE195F, LEU12A, LEU196F, LEU236A, LEU65A, LEU66A, LYS128A, LYS183F, LYS392F, LYS9A, MET137A, MET184F, PHE11A, PHE178F, PRO194F, SER127A, SER130A, SER133A, SER138A, THR230A, TYR126A, VAL181F, VAL193F, VAL232A
• B-C: ALA231C, ALA292B, ALA292C, ALA304B, ALA304C, ALA30B, ALA30C, ALA313B, ALA313C, ALA337B, ALA337C, ALA350B, ALA350C, ALA353B, ALA353C, ALA99B, ALA99C, ARG296B, ARG296C, ARG29B, ARG29C, ARG314B, ARG314C, ARG40B, ARG40C, ASN132B, ASN132C, ASN136B, ASN136C, ASN142B, ASN142C, ASN237C, ASN293B, ASN293C, ASN326B, ASN326C, ASN334B, ASN334C, ASN33B, ASN33C, ASN343B, ASN343C, ASN359B, ASN359C, ASN368B, ASN368C, ASN378B, ASN378C, ASN386B, ASN386C, ASP10B, ASP10C, ASP294C, ASP344B, ASP344C, ASP93B, ASP93C, GLN139C, GLN26B, GLN26C, GLN315B, GLN315C, GLN335B, GLN335C, GLN339B, GLN339C, GLN355B, GLN355C, GLN371B, GLN371C, GLN96B, GLN96C, GLU32B, GLU32C, GLU331B, GLU331C, GLU352B, GLU352C, GLU362B, GLU362C, GLU385B, GLU385C, GLY100B, GLY100C, GLY305B, GLY305C, GLY317B, GLY317C, GLY342B, GLY342C, GLY354B, GLY354C, GLY38B, GLY38C, GLY97B, GLY97C, GLY98B, GLY98C, HIS42B, HIS42C, ILE103B, ILE103C, ILE28B, ILE28C, ILE320B, ILE347B, ILE347C, ILE36B, ILE36C, ILE370B, ILE370C, ILE375B, ILE375C, ILE41B, ILE95B, ILE95C, LEU12B, LEU12C, LEU189B, LEU189C, LEU236C, LEU297B, LEU297C, LEU345B, LEU345C, LEU358B, LEU358C, LEU365B, LEU365C, LYS15C, LYS282B, LYS282C, LYS324B, LYS381B, LYS381C, MET105B, MET105C, MET321B, MET329B, MET329C, MET333B, MET333C, MET361B, MET361C, MET376B, MET376C, PHE11B, PHE11C, PHE338B, PHE338C, PHE341B, PHE341C, PHE34B, PHE34C, PHE356B, PHE356C, PHE366B, PHE366C, PHE367B, PHE367C, PHE380B, PHE380C, PHE383B, PHE383C, PRO312B, PRO312C, PRO316B, PRO316C, PRO327B, PRO327C, PRO330B, PRO330C, PRO35B, PRO35C, PRO363B, PRO363C, PRO94B, PRO94C, SER102B, SER102C, SER133C, SER140B, SER289B, SER289C, SER300B, SER300C, SER318B, SER319B, SER349B, SER349C, SER351B, SER351C, SER372C, SER374B, SER374C, SER382B, SER382C, THR101B, THR101C, THR141B, THR141C, THR27B, THR27C, THR31B, THR31C, THR346B, THR346C, THR348B, THR348C, THR377B, THR377C, THR37B, THR37C, TYR39B, TYR39C, VAL232C, VAL25B, VAL25C, VAL325B, VAL325C, VAL328B, VAL328C, VAL332B, VAL332C, VAL336B, VAL336C, VAL340B, VAL340C, VAL360B, VAL360C, VAL364B, VAL364C, VAL379B, VAL379C, VAL92B, VAL92C
• B-D: ALA192B, ALA192D, ALA292B, ALA292D, ALA299B, ALA299D, ALA304B, ALA304D, ALA353B, ALA353D, ARG186B, ARG186D, ARG296B, ARG296D, ARG303B, ARG303D, ASN293B, ASN293D, ASN326B, ASN326D, ASP191B, ASP191D, ASP294B, ASP294D, GLN190B, GLN190D, GLN315B, GLN315D, GLN335B, GLN335D, GLN355B, GLN355D, GLU308B, GLU308D, GLU331B, GLU331D, GLU352B, GLU352D, GLY185B, GLY185D, GLY301B, GLY301D, GLY305B, GLY305D, GLY317D, GLY323B, GLY323D, HIS188B, HIS188D, ILE309D, ILE320D, LEU189B, LEU189D, LEU295B, LEU295D, LEU297B, LEU297D, LEU306B, LEU306D, LEU311B, LEU311D, LEU345B, LEU345D, LYS183B, LYS183D, LYS282D, LYS324B, LYS324D, MET184B, MET184D, MET298B, MET298D, MET321B, MET321D, MET361B, MET361D, PRO194B, PRO194D, PRO302B, PRO302D, PRO322B, PRO322D, PRO327B, PRO327D, SER300B, SER300D, SER307B, SER307D, SER318B, SER349B, SER349D, THR187B, THR187D, THR346D, THR348B, THR348D, VAL193B, VAL193D, VAL310B, VAL310D, VAL325B, VAL325D, VAL328B, VAL328D
• B-E: ALA179B, ALA231E, ALA238E, ALA393B, ARG303B, ASN132E, ASN136E, ASN237E, ASN394B, ASN60E, ASP10E, ASP176B, ASP239E, ASP67E, GLN139E, GLN199B, GLU14E, GLU177B, GLY13E, GLY180B, GLY64E, HIS134E, ILE182B, ILE195B, LEU12E, LEU196B, LEU197B, LEU236E, LEU65E, LEU66E, LYS128E, LYS183B, LYS392B, LYS9E, MET137E, MET184B, PHE11E, PHE178B, PRO194B, SER127E, SER130E, SER133E, SER138E, SER140E, THR230E, TYR126E, VAL181B, VAL193B
• B-F: ALA192B, ALA192F, ASP191B, ASP191F, ILE182B, ILE182F, MET184B, MET184F, PRO194B, PRO194F, VAL193B, VAL193F
• B-H: ALA192B, ARG186B, ARG303H, ASP191B, GLN190B, GLU308B, GLY185B, GLY323H, ILE182B, ILE195B, ILE320H, LEU189B, LEU196B, LEU306B, LYS183B, LYS324H, MET184B, MET321H, PRO194B, PRO302H, PRO322H, SER318H, SER319H, VAL181B, VAL193B
• C-D: ALA175C, ALA175D, ALA192C, ALA192D, ALA203C, ALA203D, ALA205C, ALA205D, ALA209C, ALA209D, ALA229C, ALA231C, ALA231D, ALA261C, ALA261D, ALA267C, ALA267D, ALA280C, ALA280D, ALA292C, ALA292D, ALA299C, ALA299D, ALA337C, ALA337D, ALA350C, ALA350D, ALA353C, ALA353D, ALA99C, ALA99D, ARG186C, ARG186D, ARG206C, ARG206D, ARG210C, ARG210D, ARG214C, ARG214D, ARG259C, ARG259D, ARG296C, ARG296D, ASN142C, ASN142D, ASN217C, ASN217D, ASN220C, ASN220D, ASN221C, ASN221D, ASN237C, ASN237D, ASN270C, ASN270D, ASN287C, ASN287D, ASN293C, ASN293D, ASN334C, ASN334D, ASN359C, ASN359D, ASP191C, ASP191D, ASP211C, ASP211D, ASP224C, ASP224D, ASP266C, ASP266D, ASP272C, ASP272D, ASP294C, ASP294D, ASP344C, ASP344D, CYS273C, CYS273D, CYS284C, CYS284D, GLN190C, GLN190D, GLN199C, GLN199D, GLN262C, GLN262D, GLN269C, GLN269D, GLN355C, GLN355D, GLU200C, GLU200D, GLU202C, GLU202D, GLU213C, GLU213D, GLU276C, GLU276D, GLU308C, GLU308D, GLU352C, GLU352D, GLU357C, GLU357D, GLY100C, GLY100D, GLY185C, GLY185D, GLY198C, GLY198D, GLY233C, GLY233D, GLY235C, GLY235D, GLY342C, GLY342D, GLY354C, GLY354D, GLY97C, GLY97D, GLY98C, GLY98D, HIS188C, HIS188D, HIS263C, HIS263D, ILE195C, ILE195D, ILE208C, ILE208D, ILE286C, ILE286D, ILE291C, ILE291D, ILE309C, ILE309D, ILE347C, ILE347D, LEU189C, LEU189D, LEU196C, LEU196D, LEU197C, LEU197D, LEU222C, LEU222D, LEU236C, LEU236D, LEU264C, LEU264D, LEU281C, LEU295C, LEU295D, LEU297C, LEU297D, LEU306C, LEU306D, LEU345C, LEU345D, LEU358C, LEU358D, LEU365C, LEU365D, LYS183C, LYS183D, LYS282C, LYS282D, LYS290C, LYS290D, MET172C, MET172D, MET184C, MET184D, MET285C, MET285D, MET288C, MET288D, MET298C, MET298D, MET361C, MET361D, PHE201C, PHE201D, PHE338C, PHE338D, PHE341C, PHE341D, PHE356C, PHE356D, PRO194C, PRO194D, PRO363C, PRO363D, SER140C, SER140D, SER260C, SER260D, SER278C, SER278D, SER279C, SER279D, SER289C, SER289D, SER300C, SER300D, SER349C, SER349D, SER351C, SER351D, THR101C, THR101D, THR141C, THR141D, THR187C, THR187D, THR218C, THR218D, THR230C, THR230D, THR234C, THR234D, THR268C, THR268D, THR271C, THR271D, THR275C, THR275D, THR348C, THR348D, TYR204C, TYR204D, TYR274C, TYR274D, VAL193C, VAL193D, VAL207C, VAL207D, VAL232C, VAL232D, VAL265C, VAL265D, VAL277C, VAL277D, VAL283C, VAL283D, VAL340C, VAL340D, VAL360C, VAL360D
• D-F: ALA192F, ARG186F, ARG303D, ASP191F, GLN190F, GLU308F, GLY185F, GLY323D, ILE182F, ILE195F, ILE320D, LEU306F, LYS183F, LYS324D, MET184F, MET321D, PRO194F, PRO302D, PRO322D, SER318D, SER319D, VAL181F, VAL193F
• D-H: ALA299D, ALA299H, ALA304D, ALA304H, ALA313D, ALA313H, ARG303D, ARG303H, ASN326D, ASN326H, ASN394D, ASN394H, GLY301D, GLY301H, GLY305D, GLY305H, GLY323D, GLY323H, ILE309D, ILE309H, LEU311D, LEU311H, LYS324D, LYS324H, MET321D, MET321H, PRO302D, PRO302H, PRO322D, PRO322H, PRO327D, SER300D, SER300H, SER307D, SER307H, SER318D, SER318H, VAL310D, VAL310H, VAL325D, VAL325H
• E-F: ALA175E, ALA175F, ALA192E, ALA192F, ALA203E, ALA203F, ALA205E, ALA205F, ALA209E, ALA209F, ALA229F, ALA231E, ALA231F, ALA261E, ALA261F, ALA267E, ALA267F, ALA280E, ALA280F, ALA292E, ALA292F, ALA299E, ALA299F, ALA337E, ALA337F, ALA350E, ALA350F, ALA353E, ALA353F, ALA99E, ALA99F, ARG186E, ARG186F, ARG206E, ARG206F, ARG210E, ARG210F, ARG214E, ARG214F, ARG259E, ARG259F, ARG296E, ARG296F, ASN142E, ASN142F, ASN217E, ASN217F, ASN220E, ASN220F, ASN221E, ASN221F, ASN237F, ASN270E, ASN270F, ASN287E, ASN287F, ASN293E, ASN293F, ASN334E, ASN334F, ASN343F, ASN359E, ASN359F, ASP191E, ASP191F, ASP211E, ASP211F, ASP224E, ASP224F, ASP266E, ASP266F, ASP272E, ASP272F, ASP294E, ASP294F, ASP344E, ASP344F, CYS273E, CYS273F, CYS284E, CYS284F, GLN190E, GLN190F, GLN199E, GLN199F, GLN262E, GLN262F, GLN269E, GLN269F, GLN355E, GLN355F, GLU200E, GLU200F, GLU202E, GLU202F, GLU213E, GLU213F, GLU276E, GLU276F, GLU308E, GLU308F, GLU352E, GLU352F, GLU357E, GLU357F, GLY100E, GLY100F, GLY185E, GLY185F, GLY198E, GLY198F, GLY233E, GLY233F, GLY235E, GLY235F, GLY342E, GLY342F, GLY354E, GLY354F, GLY97E, GLY97F, GLY98E, GLY98F, HIS188E, HIS188F, HIS263E, HIS263F, ILE195E, ILE195F, ILE208E, ILE208F, ILE286E, ILE286F, ILE291E, ILE291F, ILE309E, ILE309F, ILE347E, ILE347F, LEU189E, LEU189F, LEU196E, LEU196F, LEU197E, LEU197F, LEU222E, LEU222F, LEU236E, LEU236F, LEU264E, LEU264F, LEU281F, LEU295E, LEU295F, LEU297E, LEU297F, LEU306E, LEU306F, LEU345E, LEU345F, LEU358E, LEU358F, LEU365E, LEU365F, LYS183E, LYS183F, LYS282E, LYS282F, LYS290E, LYS290F, MET172E, MET172F, MET184E, MET184F, MET285E, MET285F, MET288E, MET288F, MET298E, MET298F, MET361E, MET361F, PHE201E, PHE201F, PHE338E, PHE338F, PHE341E, PHE341F, PHE356E, PHE356F, PRO194E, PRO194F, PRO363E, PRO363F, SER140E, SER260F, SER278E, SER278F, SER279E, SER279F, SER289E, SER289F, SER300E, SER300F, SER349E, SER349F, SER351E, SER351F, THR101E, THR101F, THR141E, THR141F, THR187E, THR187F, THR218E, THR218F, THR230E, THR230F, THR234E, THR234F, THR268E, THR268F, THR271E, THR271F, THR275E, THR275F, THR346F, THR348E, THR348F, TYR204E, TYR204F, TYR274E, TYR274F, VAL193E, VAL193F, VAL207E, VAL207F, VAL232E, VAL232F, VAL265E, VAL265F, VAL277E, VAL277F, VAL283E, VAL283F, VAL340E, VAL340F, VAL360E, VAL360F
• E-G: ALA192E, ALA192G, ALA292E, ALA292G, ALA299E, ALA299G, ALA304E, ALA304G, ALA313E, ALA353E, ALA353G, ARG186E, ARG186G, ARG296E, ARG296G, ARG303E, ARG303G, ASN293E, ASN293G, ASN326E, ASN326G, ASP191E, ASP191G, ASP294E, ASP294G, GLN190E, GLN190G, GLN315E, GLN315G, GLN335E, GLN335G, GLN355E, GLN355G, GLU308E, GLU308G, GLU331E, GLU331G, GLU352E, GLU352G, GLY185E, GLY185G, GLY301E, GLY301G, GLY305E, GLY305G, GLY323E, HIS188E, HIS188G, ILE309E, ILE309G, ILE320E, LEU189E, LEU189G, LEU295E, LEU295G, LEU297E, LEU297G, LEU306E, LEU306G, LEU311E, LEU311G, LEU345E, LEU345G, LYS183E, LYS183G, LYS282E, LYS324E, MET184E, MET184G, MET298E, MET298G, MET321E, MET361E, MET361G, PRO194G, PRO302E, PRO302G, PRO327E, PRO327G, SER300E, SER300G, SER307E, SER307G, SER318E, SER319E, SER349E, SER349G, THR187E, THR187G, THR346E, THR348E, THR348G, VAL193G, VAL310E, VAL310G, VAL325E, VAL325G, VAL328E, VAL328G
• E-H: ALA144E, ALA229E, ALA229H, ALA231E, ALA231H, ALA238H, ALA292E, ALA292H, ALA304H, ALA30E, ALA30H, ALA313E, ALA313H, ALA337E, ALA337H, ALA350E, ALA350H, ALA353E, ALA353H, ALA99E, ALA99H, ARG296E, ARG296H, ARG29E, ARG29H, ARG314E, ARG314H, ARG40E, ARG40H, ASN104E, ASN104H, ASN108E, ASN132E, ASN132H, ASN136E, ASN136H, ASN142E, ASN142H, ASN237E, ASN237H, ASN293E, ASN293H, ASN326E, ASN326H, ASN334E, ASN334H, ASN33E, ASN33H, ASN343E, ASN343H, ASN359E, ASN359H, ASN368E, ASN368H, ASN378E, ASN378H, ASN386E, ASN386H, ASP10E, ASP10H, ASP143E, ASP294H, ASP344E, ASP344H, ASP93E, ASP93H, GLN139E, GLN139H, GLN26E, GLN26H, GLN315E, GLN315H, GLN335E, GLN335H, GLN339E, GLN339H, GLN355E, GLN355H, GLN371E, GLN371H, GLN96E, GLN96H, GLU32E, GLU32H, GLU331E, GLU331H, GLU352E, GLU352H, GLU357E, GLU362E, GLU362H, GLU385E, GLU385H, GLY100E, GLY100H, GLY233E, GLY233H, GLY235E, GLY235H, GLY305H, GLY317E, GLY317H, GLY342E, GLY342H, GLY354E, GLY354H, GLY38E, GLY38H, GLY97E, GLY97H, GLY98E, GLY98H, HIS42E, HIS42H, ILE103E, ILE103H, ILE28E, ILE28H, ILE320E, ILE320H, ILE347E, ILE347H, ILE36E, ILE36H, ILE370E, ILE375E, ILE375H, ILE41E, ILE95E, ILE95H, LEU12E, LEU12H, LEU189E, LEU189H, LEU236E, LEU236H, LEU297E, LEU297H, LEU306E, LEU345E, LEU345H, LEU358E, LEU358H, LEU365E, LEU365H, LEU369E, LYS282E, LYS282H, LYS324E, LYS324H, LYS381E, LYS381H, MET105E, MET105H, MET137E, MET137H, MET321E, MET321H, MET329E, MET329H, MET333E, MET333H, MET361E, MET361H, MET376E, MET376H, PHE11E, PHE11H, PHE145E, PHE338E, PHE338H, PHE341E, PHE341H, PHE34E, PHE34H, PHE356E, PHE356H, PHE366E, PHE366H, PHE367E, PHE367H, PHE380E, PHE380H, PHE383E, PHE383H, PRO131E, PRO312E, PRO312H, PRO316E, PRO316H, PRO322E, PRO322H, PRO327E, PRO327H, PRO330E, PRO330H, PRO35E, PRO35H, PRO363E, PRO363H, PRO94E, PRO94H, SER102E, SER102H, SER130E, SER133E, SER138E, SER138H, SER140E, SER140H, SER289E, SER289H, SER300E, SER300H, SER318E, SER318H, SER319E, SER319H, SER349E, SER349H, SER351E, SER351H, SER374E, SER374H, SER382E, SER382H, THR101E, THR101H, THR141E, THR141H, THR230E, THR230H, THR234E, THR234H, THR27E, THR31E, THR31H, THR346E, THR346H, THR348E, THR348H, THR377E, THR377H, THR37E, THR37H, TYR39E, TYR39H, VAL232E, VAL232H, VAL25E, VAL25H, VAL325E, VAL325H, VAL328E, VAL328H, VAL332E, VAL332H, VAL336E, VAL336H, VAL340E, VAL340H, VAL360E, VAL360H, VAL364E, VAL364H, VAL379E, VAL379H, VAL92E
• F-G: ALA231G, ALA292F, ALA292G, ALA304F, ALA304G, ALA30F, ALA30G, ALA313F, ALA313G, ALA337F, ALA337G, ALA350F, ALA350G, ALA353F, ALA353G, ALA99F, ALA99G, ARG296F, ARG296G, ARG29F, ARG29G, ARG314F, ARG314G, ARG40F, ARG40G, ASN104F, ASN132F, ASN132G, ASN136G, ASN142F, ASN142G, ASN237G, ASN293F, ASN293G, ASN326F, ASN326G, ASN334F, ASN334G, ASN33F, ASN33G, ASN343F, ASN343G, ASN359F, ASN359G, ASN368F, ASN368G, ASN378F, ASN378G, ASN386F, ASN386G, ASP10F, ASP10G, ASP294F, ASP344F, ASP344G, ASP93F, ASP93G, GLN139G, GLN26F, GLN26G, GLN315F, GLN315G, GLN335F, GLN335G, GLN339F, GLN339G, GLN355F, GLN355G, GLN371F, GLN371G, GLN96F, GLN96G, GLU32F, GLU32G, GLU331F, GLU331G, GLU352F, GLU352G, GLU362F, GLU362G, GLU385F, GLU385G, GLY100F, GLY100G, GLY305F, GLY305G, GLY317F, GLY317G, GLY342F, GLY342G, GLY354F, GLY354G, GLY38F, GLY38G, GLY97F, GLY97G, GLY98F, GLY98G, HIS42F, HIS42G, ILE103F, ILE103G, ILE28F, ILE28G, ILE320F, ILE347F, ILE347G, ILE36F, ILE36G, ILE370F, ILE370G, ILE375F, ILE375G, ILE41G, ILE95F, ILE95G, LEU12F, LEU12G, LEU189F, LEU189G, LEU236G, LEU297F, LEU297G, LEU306F, LEU306G, LEU345F, LEU345G, LEU358F, LEU358G, LEU365F, LEU365G, LYS282F, LYS282G, LYS324F, LYS381F, LYS381G, LYS9F, MET105F, MET105G, MET137G, MET285F, MET321F, MET329F, MET329G, MET333F, MET333G, MET361F, MET361G, MET376F, MET376G, PHE11F, PHE11G, PHE338F, PHE338G, PHE341F, PHE341G, PHE34F, PHE34G, PHE356F, PHE356G, PHE366F, PHE366G, PHE367F, PHE367G, PHE380F, PHE380G, PHE383F, PHE383G, PRO312F, PRO312G, PRO316F, PRO316G, PRO327F, PRO327G, PRO330F, PRO330G, PRO35F, PRO35G, PRO363F, PRO363G, PRO94F, PRO94G, SER102F, SER102G, SER133G, SER138G, SER140G, SER289F, SER289G, SER300F, SER300G, SER318F, SER319F, SER349F, SER349G, SER351F, SER351G, SER374F, SER374G, SER382F, SER382G, THR101F, THR101G, THR141F, THR141G, THR230G, THR31F, THR31G, THR346F, THR346G, THR348F, THR348G, THR377F, THR377G, THR37F, THR37G, TYR39F, TYR39G, VAL232G, VAL25F, VAL25G, VAL325F, VAL325G, VAL328F, VAL328G, VAL332F, VAL332G, VAL336F, VAL336G, VAL340F, VAL340G, VAL360F, VAL360G, VAL364F, VAL364G, VAL379F, VAL379G
• F-H: ALA192F, ALA192H, ALA292F, ALA292H, ALA299F, ALA299H, ALA304F, ALA304H, ALA353F, ALA353H, ARG186F, ARG186H, ARG296F, ARG296H, ARG303F, ARG303H, ASN293F, ASN293H, ASN326F, ASN326H, ASP191F, ASP191H, ASP294F, ASP294H, ASP344F, ASP344H, GLN190F, GLN190H, GLN315F, GLN315H, GLN335F, GLN335H, GLN355F, GLN355H, GLU308F, GLU308H, GLU331F, GLU331H, GLU352F, GLU352H, GLY185F, GLY185H, GLY301F, GLY301H, GLY305F, GLY305H, GLY317H, GLY323F, GLY323H, HIS188F, HIS188H, ILE309F, ILE309H, ILE320F, ILE320H, LEU189F, LEU189H, LEU295F, LEU295H, LEU297F, LEU297H, LEU306F, LEU306H, LEU311F, LEU311H, LEU345F, LEU345H, LYS183F, LYS183H, LYS282H, LYS324F, LYS324H, MET184F, MET184H, MET298F, MET298H, MET321F, MET321H, MET361F, MET361H, PHE341F, PRO194F, PRO194H, PRO302F, PRO302H, PRO327F, PRO327H, SER300F, SER300H, SER307F, SER307H, SER318F, SER349F, SER349H, THR187F, THR187H, THR348F, THR348H, VAL193F, VAL193H, VAL310F, VAL310H, VAL325F, VAL325H, VAL328F, VAL328H
• G-H: ALA175G, ALA175H, ALA192G, ALA192H, ALA203G, ALA203H, ALA205G, ALA205H, ALA209G, ALA209H, ALA229G, ALA231G, ALA231H, ALA261G, ALA261H, ALA267G, ALA267H, ALA280G, ALA280H, ALA292G, ALA292H, ALA299G, ALA299H, ALA337G, ALA337H, ALA350G, ALA350H, ALA353G, ALA353H, ALA99G, ALA99H, ARG186G, ARG186H, ARG206G, ARG206H, ARG210G, ARG210H, ARG214G, ARG214H, ARG259G, ARG259H, ARG296G, ARG296H, ASN142G, ASN142H, ASN217G, ASN217H, ASN220G, ASN220H, ASN221G, ASN221H, ASN237G, ASN237H, ASN270G, ASN270H, ASN287G, ASN287H, ASN293G, ASN293H, ASN334G, ASN334H, ASN359G, ASN359H, ASP191H, ASP211G, ASP211H, ASP224G, ASP224H, ASP266G, ASP266H, ASP272G, ASP272H, ASP294G, ASP294H, ASP344G, ASP344H, CYS273G, CYS273H, CYS284G, CYS284H, GLN190G, GLN190H, GLN199G, GLN199H, GLN262G, GLN262H, GLN269G, GLN269H, GLN355G, GLN355H, GLU200G, GLU200H, GLU202G, GLU202H, GLU213G, GLU213H, GLU276G, GLU276H, GLU308G, GLU308H, GLU352G, GLU352H, GLU357G, GLU357H, GLY100G, GLY100H, GLY185G, GLY185H, GLY198G, GLY198H, GLY233G, GLY233H, GLY235G, GLY235H, GLY342G, GLY342H, GLY354G, GLY354H, GLY97G, GLY97H, GLY98G, GLY98H, HIS188G, HIS188H, HIS263G, HIS263H, ILE195G, ILE195H, ILE208G, ILE208H, ILE286G, ILE286H, ILE291G, ILE291H, ILE309G, ILE309H, ILE347G, ILE347H, LEU189G, LEU189H, LEU196G, LEU196H, LEU197G, LEU197H, LEU222H, LEU236G, LEU236H, LEU264G, LEU264H, LEU281G, LEU281H, LEU295G, LEU295H, LEU297G, LEU297H, LEU306G, LEU306H, LEU345G, LEU345H, LEU358G, LEU358H, LEU365G, LEU365H, LYS183G, LYS183H, LYS282G, LYS282H, LYS290G, LYS290H, MET172G, MET172H, MET184G, MET184H, MET285G, MET285H, MET288G, MET288H, MET298G, MET298H, MET361G, MET361H, PHE201G, PHE201H, PHE338G, PHE338H, PHE341G, PHE341H, PHE356G, PHE356H, PRO194G, PRO194H, PRO363G, PRO363H, SER140G, SER140H, SER260G, SER260H, SER278G, SER278H, SER279G, SER279H, SER289G, SER289H, SER300G, SER300H, SER349G, SER349H, SER351G, SER351H, THR101G, THR101H, THR141G, THR141H, THR187G, THR187H, THR218G, THR218H, THR230G, THR230H, THR234G, THR234H, THR268G, THR268H, THR271G, THR271H, THR275G, THR275H, THR348G, THR348H, TYR204G, TYR204H, TYR274G, TYR274H, VAL193G, VAL193H, VAL207G, VAL207H, VAL232G, VAL232H, VAL265G, VAL265H, VAL277G, VAL277H, VAL283G, VAL283H, VAL340G, VAL340H, VAL360G, VAL360H