3R6V

crystal structure of aspartase from bacillus sp. ym55-1 with bound l- aspartate

• Total interactions analyzed: 28
• Total true interactions: 16
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 305
  • Norm. En. per Res.: -4.5088
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-162.6372	-252.6712	-900.031	-1315.3394	310	36	18	37284	25	74	69
A-C	-101.7316	-25.758	-460.218	-587.7075	172	31	8	17717	4	25	32
A-D	-81.2513	-5.1311	-619.545	-705.9273	228	22	21	25883	0	21	12
B-C	-105.5801	-8.3291	-676.104	-790.0131	254	23	23	28786	0	23	13
B-D	-96.1046	-24.7568	-523.072	-643.9335	183	34	13	20549	4	28	33
C-D	-207.4028	-239.4624	-928.305	-1375.1702	305	37	18	37667	25	72	68
C-E	0.0	0.0	-0.051	-0.051	4	0	0	21	0	0	1
D-E	0.0	0.0	-0.086	-0.086	4	0	0	22	0	2	4
D-F	-19.3759	-47.3116	-89.7124	-156.3999	44	6	1	4307	5	21	19
D-H	-17.03	30.7678	-31.8086	-18.0708	33	2	0	1273	0	18	21
E-F	-161.4841	-234.8665	-915.869	-1312.2196	312	40	18	37379	26	73	70
E-G	-117.0124	-23.5282	-463.195	-603.7357	173	28	9	18026	4	25	33
E-H	-122.1613	-8.177	-619.114	-749.4523	229	21	21	26108	0	21	12
F-G	-91.1318	-6.412	-679.989	-777.5328	254	15	23	28614	0	22	13
F-H	-98.3322	-34.1867	-533.218	-665.7369	182	38	13	20649	4	28	34
G-H	-210.1576	-246.6395	-926.31	-1383.107	308	42	18	37627	26	73	67

Interface residues

• A-B: ALA175A, ALA175B, ALA192A, ALA192B, ALA203A, ALA203B, ALA205A, ALA205B, ALA209B, ALA229A, ALA229B, ALA231A, ALA231B, ALA238A, ALA238B, ALA261A, ALA261B, ALA267A, ALA267B, ALA280A, ALA280B, ALA292A, ALA292B, ALA299A, ALA299B, ALA337A, ALA337B, ALA350A, ALA350B, ALA353A, ALA353B, ALA411A, ALA411B, ALA422A, ALA465B, ALA99A, ALA99B, ARG186A, ARG186B, ARG206A, ARG206B, ARG210A, ARG210B, ARG214A, ARG214B, ARG259A, ARG259B, ARG296A, ARG296B, ARG426A, ASN142A, ASN142B, ASN217A, ASN217B, ASN220A, ASN220B, ASN221A, ASN221B, ASN237A, ASN237B, ASN270A, ASN270B, ASN287A, ASN287B, ASN293A, ASN293B, ASN334A, ASN334B, ASN359A, ASN359B, ASN413A, ASN413B, ASN455B, ASP191A, ASP211A, ASP211B, ASP224A, ASP224B, ASP239A, ASP239B, ASP266A, ASP266B, ASP272A, ASP272B, ASP294A, ASP294B, ASP344A, ASP344B, CYS273A, CYS273B, CYS284A, CYS284B, GLN190A, GLN190B, GLN199A, GLN199B, GLN262A, GLN262B, GLN269A, GLN269B, GLN355A, GLN355B, GLN96B, GLU200A, GLU200B, GLU202A, GLU202B, GLU213A, GLU213B, GLU241A, GLU241B, GLU276A, GLU276B, GLU308A, GLU308B, GLU352A, GLU352B, GLU357A, GLU357B, GLU458A, GLU458B, GLY100A, GLY100B, GLY185A, GLY185B, GLY198A, GLY198B, GLY228A, GLY228B, GLY233A, GLY233B, GLY235A, GLY235B, GLY342A, GLY342B, GLY354A, GLY354B, GLY407A, GLY407B, GLY463B, GLY97A, GLY97B, GLY98A, GLY98B, HIS188A, HIS188B, HIS263A, HIS263B, HIS415A, HIS415B, HIS461A, HIS461B, ILE182A, ILE182B, ILE195A, ILE195B, ILE208A, ILE208B, ILE243A, ILE243B, ILE286A, ILE286B, ILE291A, ILE291B, ILE309A, ILE309B, ILE347A, ILE347B, ILE408A, ILE408B, ILE409A, ILE409B, ILE412A, ILE412B, ILE453A, ILE453B, ILE460A, ILE460B, ILE464B, LEU189A, LEU189B, LEU196A, LEU196B, LEU197A, LEU197B, LEU236A, LEU236B, LEU264A, LEU264B, LEU281A, LEU281B, LEU295A, LEU295B, LEU297A, LEU297B, LEU306A, LEU306B, LEU345A, LEU345B, LEU358A, LEU358B, LEU365A, LEU365B, LEU454A, LEU454B, LEU65A, LEU65B, LYS183A, LYS183B, LYS282A, LYS282B, LYS290A, LYS290B, MET137B, MET172A, MET172B, MET184A, MET184B, MET285A, MET285B, MET288A, MET288B, MET298A, MET298B, MET361A, MET361B, MET459A, MET459B, PHE11B, PHE201A, PHE201B, PHE338A, PHE338B, PHE341A, PHE341B, PHE356A, PHE356B, PRO194A, PRO194B, PRO240A, PRO240B, PRO363A, PRO363B, PRO414A, PRO414B, PRO456B, PRO462A, PRO462B, SER133B, SER140A, SER140B, SER278A, SER278B, SER279A, SER279B, SER289A, SER289B, SER300A, SER300B, SER349A, SER349B, SER351A, SER351B, THR101A, THR101B, THR141A, THR141B, THR187A, THR187B, THR218A, THR218B, THR230A, THR230B, THR234A, THR234B, THR268A, THR268B, THR271A, THR271B, THR275A, THR275B, THR348A, THR348B, THR410A, THR410B, TYR204A, TYR204B, TYR242A, TYR242B, TYR274A, TYR274B, TYR418A, TYR457A, TYR457B, VAL193A, VAL193B, VAL207A, VAL207B, VAL232A, VAL232B, VAL265A, VAL265B, VAL277A, VAL277B, VAL283A, VAL283B, VAL340A, VAL360A, VAL360B, VAL63A
• A-C: ALA192A, ALA192C, ALA292A, ALA292C, ALA299A, ALA299C, ALA304A, ALA304C, ALA353A, ALA353C, ALA411C, ALA421C, ALA422A, ALA422C, ALA425A, ALA425C, ALA428A, ALA428C, ARG186A, ARG186C, ARG296A, ARG296C, ARG303A, ARG303C, ARG397A, ARG397C, ARG426A, ARG426C, ASN293A, ASN293C, ASN326A, ASN326C, ASN334A, ASN394A, ASN413A, ASN413C, ASP191A, ASP191C, ASP294A, ASP294C, ASP344A, ASP344C, GLN190A, GLN190C, GLN315A, GLN315C, GLN335A, GLN335C, GLN355A, GLN355C, GLU308A, GLU308C, GLU331A, GLU331C, GLU352A, GLU352C, GLU400A, GLU400C, GLU403A, GLU403C, GLU419C, GLU427A, GLU427C, GLU433A, GLU433C, GLY185A, GLY185C, GLY301A, GLY301C, GLY305A, GLY305C, GLY317C, GLY323A, GLY323C, GLY407A, GLY407C, GLY432A, GLY432C, HIS188A, HIS188C, ILE309C, ILE320A, ILE320C, ILE406A, ILE406C, ILE408A, ILE408C, ILE409A, ILE409C, ILE412C, ILE435A, ILE435C, LEU189A, LEU189C, LEU295A, LEU295C, LEU297A, LEU297C, LEU306A, LEU306C, LEU311A, LEU311C, LEU345A, LEU345C, LEU424C, LEU430A, LEU430C, LEU438C, LYS183A, LYS183C, LYS324A, LYS324C, LYS404A, LYS404C, LYS423C, MET184A, MET184C, MET298A, MET298C, MET321A, MET321C, MET361A, MET361C, MET398A, MET398C, PRO194A, PRO194C, PRO302A, PRO302C, PRO322A, PRO322C, PRO327A, PRO327C, PRO414C, SER300A, SER300C, SER307A, SER307C, SER318A, SER318C, SER319A, SER319C, SER349A, SER349C, SER405A, SER405C, SER434A, SER434C, THR187A, THR187C, THR346A, THR348A, THR348C, THR410A, THR410C, THR431A, THR431C, TYR401A, TYR401C, TYR418C, TYR429A, TYR429C, VAL193A, VAL193C, VAL310A, VAL310C, VAL325A, VAL325C, VAL328A, VAL328C, VAL402A, VAL402C
• A-D: ALA231A, ALA231D, ALA292A, ALA292D, ALA304A, ALA30A, ALA30D, ALA313A, ALA313D, ALA337A, ALA337D, ALA350A, ALA350D, ALA353A, ALA353D, ALA99A, ALA99D, ARG296A, ARG296D, ARG29A, ARG29D, ARG314A, ARG314D, ARG40A, ARG40D, ASN132A, ASN132D, ASN142A, ASN142D, ASN237D, ASN293A, ASN293D, ASN326A, ASN326D, ASN334A, ASN334D, ASN33A, ASN33D, ASN343A, ASN343D, ASN359A, ASN359D, ASN368A, ASN368D, ASN378A, ASN378D, ASN386A, ASN386D, ASP10A, ASP10D, ASP344A, ASP344D, ASP93A, ASP93D, GLN26A, GLN26D, GLN315A, GLN315D, GLN335A, GLN335D, GLN339A, GLN339D, GLN355A, GLN355D, GLN371A, GLN371D, GLN96A, GLN96D, GLU109A, GLU109D, GLU32A, GLU32D, GLU331A, GLU331D, GLU352A, GLU352D, GLU362A, GLU362D, GLU385A, GLU385D, GLY100A, GLY100D, GLY305A, GLY317A, GLY317D, GLY342A, GLY342D, GLY354A, GLY354D, GLY38A, GLY38D, GLY97A, GLY97D, GLY98A, GLY98D, HIS42A, HIS42D, ILE28A, ILE28D, ILE320A, ILE347A, ILE347D, ILE36A, ILE36D, ILE370A, ILE375A, ILE375D, ILE95A, ILE95D, LEU12A, LEU12D, LEU189D, LEU236A, LEU236D, LEU297A, LEU297D, LEU345A, LEU345D, LEU358A, LEU358D, LEU365A, LEU365D, LYS15D, LYS282A, LYS282D, LYS324A, LYS324D, LYS381A, LYS381D, MET105A, MET105D, MET321A, MET321D, MET329A, MET329D, MET333A, MET333D, MET361A, MET361D, MET376A, MET376D, PHE11A, PHE11D, PHE338A, PHE338D, PHE341A, PHE341D, PHE34A, PHE34D, PHE356A, PHE356D, PHE366A, PHE366D, PHE367A, PHE367D, PHE380A, PHE380D, PHE383A, PHE383D, PRO312A, PRO312D, PRO316A, PRO316D, PRO327A, PRO327D, PRO330A, PRO330D, PRO35A, PRO35D, PRO363A, PRO363D, PRO94A, PRO94D, SER102A, SER102D, SER289A, SER289D, SER300A, SER300D, SER318A, SER318D, SER319A, SER349A, SER349D, SER351A, SER351D, SER374A, SER374D, SER382A, SER382D, THR101A, THR101D, THR141A, THR141D, THR27A, THR27D, THR31A, THR31D, THR346A, THR346D, THR348A, THR348D, THR377A, THR377D, THR37A, THR37D, TYR39A, TYR39D, VAL232A, VAL232D, VAL25A, VAL25D, VAL325A, VAL325D, VAL328A, VAL328D, VAL332A, VAL332D, VAL336A, VAL336D, VAL340A, VAL340D, VAL360A, VAL360D, VAL364A, VAL364D, VAL379A, VAL379D
• B-C: ALA144B, ALA229B, ALA231B, ALA231C, ALA238B, ALA292B, ALA292C, ALA304B, ALA304C, ALA30B, ALA30C, ALA313B, ALA313C, ALA337B, ALA337C, ALA350B, ALA350C, ALA353B, ALA353C, ALA99B, ALA99C, ARG296B, ARG296C, ARG29B, ARG29C, ARG314B, ARG314C, ARG40B, ARG40C, ASN104B, ASN108B, ASN132B, ASN132C, ASN136B, ASN142B, ASN142C, ASN237B, ASN293B, ASN293C, ASN326B, ASN326C, ASN334B, ASN334C, ASN33B, ASN33C, ASN343B, ASN343C, ASN359B, ASN359C, ASN368B, ASN368C, ASN378B, ASN378C, ASN386B, ASN386C, ASP10B, ASP10C, ASP143B, ASP344B, ASP344C, ASP93B, ASP93C, GLN139B, GLN26B, GLN26C, GLN315B, GLN315C, GLN335B, GLN335C, GLN339B, GLN339C, GLN355B, GLN355C, GLN371B, GLN371C, GLN96B, GLN96C, GLU109C, GLU32B, GLU32C, GLU331B, GLU331C, GLU352B, GLU352C, GLU357B, GLU362B, GLU362C, GLU385B, GLU385C, GLY100B, GLY100C, GLY13B, GLY233B, GLY235B, GLY305B, GLY305C, GLY317B, GLY317C, GLY323C, GLY342B, GLY342C, GLY354B, GLY354C, GLY38B, GLY38C, GLY97B, GLY97C, GLY98B, GLY98C, HIS42C, ILE103B, ILE28B, ILE28C, ILE320C, ILE347B, ILE347C, ILE36B, ILE36C, ILE370C, ILE375B, ILE375C, ILE41C, ILE95B, ILE95C, LEU12B, LEU12C, LEU189B, LEU189C, LEU236B, LEU297B, LEU297C, LEU345B, LEU345C, LEU358B, LEU358C, LEU365B, LEU365C, LYS15B, LYS15C, LYS282B, LYS282C, LYS324B, LYS324C, LYS381B, LYS381C, LYS53B, LYS9B, MET105B, MET105C, MET137B, MET321B, MET321C, MET329B, MET329C, MET333B, MET333C, MET361B, MET361C, MET376B, MET376C, PHE11B, PHE11C, PHE145C, PHE338B, PHE338C, PHE341B, PHE341C, PHE34B, PHE34C, PHE356B, PHE356C, PHE366B, PHE366C, PHE367B, PHE367C, PHE380B, PHE380C, PHE383B, PHE383C, PRO131B, PRO312B, PRO312C, PRO316B, PRO316C, PRO322C, PRO327B, PRO327C, PRO330B, PRO330C, PRO35B, PRO35C, PRO363B, PRO363C, PRO94B, PRO94C, SER102B, SER102C, SER133B, SER138B, SER140B, SER289B, SER289C, SER300B, SER300C, SER318B, SER318C, SER319C, SER349B, SER349C, SER351B, SER351C, SER374B, SER374C, SER382B, SER382C, THR101B, THR101C, THR141B, THR141C, THR230B, THR27B, THR31B, THR31C, THR346B, THR346C, THR348B, THR348C, THR377B, THR377C, THR37B, THR37C, TYR39B, TYR39C, VAL232B, VAL232C, VAL25B, VAL25C, VAL325B, VAL325C, VAL328B, VAL328C, VAL332B, VAL332C, VAL336B, VAL336C, VAL340B, VAL340C, VAL360B, VAL360C, VAL364B, VAL364C, VAL379B, VAL379C, VAL92B
• B-D: ALA192B, ALA192D, ALA292B, ALA292D, ALA299B, ALA299D, ALA304B, ALA304D, ALA353B, ALA353D, ALA411B, ALA411D, ALA421B, ALA421D, ALA422B, ALA422D, ALA425B, ALA425D, ALA428B, ALA428D, ARG186B, ARG186D, ARG296B, ARG296D, ARG303B, ARG303D, ARG397B, ARG397D, ARG426B, ARG426D, ASN293B, ASN293D, ASN326B, ASN326D, ASN334B, ASN394D, ASN413B, ASN413D, ASP191B, ASP191D, ASP294B, ASP294D, ASP344B, ASP344D, GLN190B, GLN190D, GLN315B, GLN315D, GLN335B, GLN335D, GLN355B, GLN355D, GLU308B, GLU308D, GLU331B, GLU331D, GLU352B, GLU352D, GLU400B, GLU400D, GLU403B, GLU403D, GLU419B, GLU419D, GLU427B, GLU427D, GLU433B, GLU433D, GLY185B, GLY185D, GLY301B, GLY301D, GLY305B, GLY305D, GLY323B, GLY323D, GLY407B, GLY407D, GLY417B, GLY417D, GLY432B, GLY432D, HIS188B, HIS188D, ILE309D, ILE320B, ILE320D, ILE406B, ILE406D, ILE408B, ILE408D, ILE409B, ILE409D, ILE412B, ILE412D, ILE435B, ILE435D, LEU189B, LEU189D, LEU295B, LEU295D, LEU297B, LEU297D, LEU306B, LEU306D, LEU311B, LEU311D, LEU345B, LEU345D, LEU424B, LEU424D, LEU430B, LEU430D, LEU438D, LYS183B, LYS183D, LYS324B, LYS324D, LYS404B, LYS404D, LYS423B, LYS423D, MET184B, MET184D, MET298B, MET298D, MET321B, MET321D, MET361B, MET361D, MET398B, MET398D, PRO194B, PRO194D, PRO302B, PRO302D, PRO322B, PRO322D, PRO327B, PRO327D, PRO414B, SER300B, SER300D, SER307B, SER307D, SER318B, SER318D, SER319B, SER319D, SER349B, SER349D, SER405B, SER405D, SER434B, SER434D, THR187B, THR187D, THR348B, THR348D, THR410B, THR410D, THR420B, THR420D, THR431B, THR431D, TYR401B, TYR401D, TYR418B, TYR418D, TYR429B, TYR429D, VAL193B, VAL193D, VAL310B, VAL310D, VAL325B, VAL325D, VAL328B, VAL328D, VAL402B, VAL402D, VAL416B, VAL416D
• C-D: ALA175C, ALA175D, ALA192C, ALA192D, ALA203C, ALA203D, ALA205C, ALA205D, ALA209D, ALA229C, ALA229D, ALA231C, ALA231D, ALA238C, ALA238D, ALA261C, ALA261D, ALA267C, ALA267D, ALA280C, ALA280D, ALA292C, ALA292D, ALA299C, ALA299D, ALA337C, ALA337D, ALA350C, ALA350D, ALA353C, ALA353D, ALA411C, ALA411D, ALA465C, ALA99C, ALA99D, ARG186C, ARG186D, ARG206C, ARG206D, ARG210C, ARG210D, ARG214C, ARG214D, ARG259C, ARG296C, ARG296D, ASN142C, ASN142D, ASN217C, ASN217D, ASN220C, ASN220D, ASN221C, ASN221D, ASN237C, ASN237D, ASN270C, ASN270D, ASN287C, ASN287D, ASN293C, ASN293D, ASN334C, ASN334D, ASN359C, ASN359D, ASN413C, ASN413D, ASN455C, ASN455D, ASP191C, ASP191D, ASP211C, ASP211D, ASP224C, ASP224D, ASP239C, ASP239D, ASP266C, ASP266D, ASP272C, ASP272D, ASP294C, ASP294D, ASP344C, ASP344D, CYS273C, CYS273D, CYS284C, CYS284D, GLN190C, GLN190D, GLN199C, GLN199D, GLN262C, GLN262D, GLN269C, GLN269D, GLN355C, GLN355D, GLU200C, GLU200D, GLU202C, GLU202D, GLU213C, GLU213D, GLU241C, GLU241D, GLU276C, GLU276D, GLU308C, GLU308D, GLU352C, GLU352D, GLU357C, GLU357D, GLU458C, GLU458D, GLY100C, GLY100D, GLY185C, GLY185D, GLY198C, GLY198D, GLY228C, GLY228D, GLY233C, GLY233D, GLY235C, GLY235D, GLY342C, GLY342D, GLY354C, GLY354D, GLY407C, GLY407D, GLY463C, GLY463D, GLY466C, GLY97C, GLY97D, GLY98C, GLY98D, HIS188C, HIS188D, HIS263C, HIS263D, HIS415C, HIS415D, HIS461C, HIS461D, ILE182C, ILE182D, ILE195C, ILE195D, ILE208C, ILE208D, ILE243C, ILE243D, ILE286C, ILE286D, ILE291C, ILE291D, ILE309C, ILE309D, ILE347C, ILE347D, ILE408C, ILE408D, ILE409C, ILE409D, ILE412C, ILE412D, ILE453C, ILE453D, ILE460C, ILE460D, ILE464C, LEU189C, LEU189D, LEU196C, LEU196D, LEU197C, LEU197D, LEU236C, LEU236D, LEU264C, LEU264D, LEU281C, LEU281D, LEU295C, LEU295D, LEU297C, LEU297D, LEU306C, LEU306D, LEU345C, LEU345D, LEU358C, LEU358D, LEU365C, LEU365D, LEU454C, LEU454D, LEU65C, LEU65D, LYS183C, LYS183D, LYS282C, LYS282D, LYS290C, LYS290D, MET172C, MET172D, MET184C, MET184D, MET285C, MET285D, MET288C, MET288D, MET298C, MET298D, MET361C, MET361D, MET459C, MET459D, PHE201C, PHE201D, PHE338C, PHE338D, PHE341C, PHE341D, PHE356C, PHE356D, PRO194C, PRO194D, PRO240C, PRO240D, PRO363C, PRO363D, PRO414C, PRO414D, PRO456D, PRO462C, PRO462D, SER140C, SER140D, SER278C, SER278D, SER279C, SER279D, SER289C, SER289D, SER300C, SER300D, SER349C, SER349D, SER351C, SER351D, THR101C, THR101D, THR141C, THR141D, THR187C, THR187D, THR218C, THR218D, THR230C, THR230D, THR234C, THR234D, THR268C, THR268D, THR271C, THR271D, THR275C, THR275D, THR348C, THR348D, THR410C, THR410D, TYR204C, TYR204D, TYR242D, TYR274C, TYR274D, TYR457C, TYR457D, VAL193C, VAL193D, VAL207C, VAL207D, VAL232C, VAL232D, VAL265C, VAL265D, VAL277C, VAL277D, VAL283C, VAL283D, VAL340D, VAL360C, VAL360D, VAL63D
• C-E: GLY13E, ILE464C, LEU12E, PHE11E
• D-E: GLU241D, LYS9E, PHE11E, PRO240D
• D-F: ALA251D, ALA428F, ALA57D, ALA59D, ARG426F, ASN60D, ASP79D, GLN72D, GLU241D, GLU248D, GLU427F, GLU433F, GLU62D, GLU69D, GLU83D, GLY432F, GLY64D, GLY71D, HIS249D, ILE245D, ILE82D, LEU424F, LEU430F, LEU438F, LEU58D, LEU66D, LYS252D, LYS423F, LYS441F, LYS54D, LYS68D, LYS76D, MET61D, PHE253D, SER244D, SER55D, THR420F, THR431F, TYR429F, TYR442F, TYR73D, VAL246D, VAL63D, VAL75D
• D-H: ALA393H, ARG303H, ARG397H, ASN394H, ASP67D, GLN72D, GLU121D, GLU241D, GLU308H, GLU395H, GLU396H, GLU400H, GLU62D, GLU69D, GLY323H, GLY64D, ILE129D, LEU65D, LEU66D, LYS128D, LYS392H, LYS399H, LYS68D, MET119D, MET398H, PRO302H, PRO322H, SER307H, SER319H, TYR73D, VAL310H, VAL325H, VAL70D
• E-F: ALA175E, ALA175F, ALA192E, ALA192F, ALA203E, ALA203F, ALA205E, ALA205F, ALA209E, ALA209F, ALA229E, ALA229F, ALA231E, ALA231F, ALA238E, ALA238F, ALA261E, ALA261F, ALA267E, ALA267F, ALA280E, ALA280F, ALA292E, ALA292F, ALA299E, ALA299F, ALA337E, ALA337F, ALA350E, ALA350F, ALA353E, ALA353F, ALA411E, ALA411F, ALA422E, ALA465F, ALA99E, ALA99F, ARG186E, ARG186F, ARG206E, ARG206F, ARG210E, ARG210F, ARG214E, ARG214F, ARG259E, ARG296E, ARG296F, ARG426E, ASN142E, ASN142F, ASN217E, ASN217F, ASN220E, ASN220F, ASN221E, ASN221F, ASN237E, ASN237F, ASN270E, ASN270F, ASN287E, ASN287F, ASN293E, ASN293F, ASN334E, ASN334F, ASN359E, ASN359F, ASN413E, ASN413F, ASN455F, ASP191E, ASP191F, ASP211E, ASP211F, ASP224E, ASP224F, ASP239E, ASP239F, ASP266E, ASP266F, ASP272E, ASP272F, ASP294E, ASP294F, ASP344E, ASP344F, CYS273E, CYS273F, CYS284E, CYS284F, GLN190E, GLN190F, GLN199E, GLN199F, GLN262E, GLN262F, GLN269E, GLN269F, GLN355E, GLN355F, GLU200E, GLU200F, GLU202E, GLU202F, GLU213E, GLU213F, GLU241E, GLU241F, GLU276E, GLU276F, GLU308E, GLU308F, GLU352E, GLU352F, GLU357E, GLU357F, GLU458E, GLU458F, GLY100E, GLY100F, GLY185E, GLY185F, GLY198E, GLY198F, GLY228E, GLY228F, GLY233E, GLY233F, GLY235E, GLY235F, GLY342E, GLY342F, GLY354E, GLY354F, GLY407E, GLY407F, GLY463E, GLY463F, GLY97E, GLY97F, GLY98E, GLY98F, HIS188E, HIS188F, HIS263E, HIS263F, HIS415E, HIS415F, HIS461E, HIS461F, ILE182E, ILE182F, ILE195E, ILE195F, ILE208E, ILE208F, ILE243E, ILE243F, ILE286E, ILE286F, ILE291E, ILE291F, ILE309E, ILE309F, ILE347E, ILE347F, ILE408E, ILE408F, ILE409E, ILE409F, ILE412E, ILE412F, ILE453E, ILE453F, ILE460E, ILE460F, ILE464F, LEU189E, LEU189F, LEU196E, LEU196F, LEU197E, LEU197F, LEU236E, LEU236F, LEU264E, LEU264F, LEU281F, LEU295E, LEU295F, LEU297E, LEU297F, LEU306E, LEU306F, LEU345E, LEU345F, LEU358E, LEU358F, LEU365E, LEU365F, LEU454F, LEU65E, LEU65F, LYS183E, LYS183F, LYS282E, LYS282F, LYS290E, LYS290F, MET137F, MET172E, MET172F, MET184E, MET184F, MET285E, MET285F, MET288E, MET288F, MET298E, MET298F, MET361E, MET361F, MET459E, MET459F, PHE11F, PHE201E, PHE201F, PHE338E, PHE338F, PHE341E, PHE341F, PHE356E, PHE356F, PRO194E, PRO194F, PRO240E, PRO240F, PRO363E, PRO363F, PRO414E, PRO414F, PRO462E, PRO462F, SER133E, SER133F, SER138F, SER140E, SER140F, SER278E, SER278F, SER279E, SER279F, SER289E, SER289F, SER300E, SER300F, SER349E, SER349F, SER351E, SER351F, THR101E, THR101F, THR141E, THR141F, THR187E, THR187F, THR218E, THR218F, THR230E, THR230F, THR234E, THR234F, THR268E, THR268F, THR271E, THR271F, THR275E, THR275F, THR348E, THR348F, THR410E, THR410F, TYR204E, TYR204F, TYR242E, TYR242F, TYR274E, TYR274F, TYR418E, TYR418F, TYR457E, TYR457F, VAL193E, VAL193F, VAL207E, VAL207F, VAL232E, VAL232F, VAL265E, VAL265F, VAL277E, VAL277F, VAL283E, VAL283F, VAL340E, VAL340F, VAL360E, VAL360F, VAL63E
• E-G: ALA192E, ALA192G, ALA292E, ALA292G, ALA299E, ALA299G, ALA304E, ALA304G, ALA353E, ALA353G, ALA411G, ALA421G, ALA422E, ALA422G, ALA425E, ALA425G, ALA428E, ALA428G, ARG186E, ARG186G, ARG296E, ARG296G, ARG303E, ARG303G, ARG397E, ARG397G, ARG426E, ARG426G, ASN293E, ASN293G, ASN326E, ASN326G, ASN334E, ASN394E, ASN413E, ASN413G, ASP191E, ASP191G, ASP294E, ASP294G, ASP344E, ASP344G, GLN190E, GLN190G, GLN315E, GLN315G, GLN335E, GLN335G, GLN355E, GLN355G, GLU308E, GLU308G, GLU331E, GLU331G, GLU352E, GLU352G, GLU400E, GLU400G, GLU403E, GLU403G, GLU419G, GLU427E, GLU427G, GLU433E, GLU433G, GLY185E, GLY185G, GLY301E, GLY301G, GLY305E, GLY305G, GLY317G, GLY323E, GLY323G, GLY407E, GLY407G, GLY417G, GLY432E, GLY432G, HIS188E, HIS188G, ILE309E, ILE320E, ILE320G, ILE406E, ILE406G, ILE408E, ILE408G, ILE409E, ILE409G, ILE412G, ILE435E, ILE435G, LEU189E, LEU189G, LEU295E, LEU295G, LEU297E, LEU297G, LEU306E, LEU306G, LEU311E, LEU311G, LEU345E, LEU345G, LEU424G, LEU430E, LEU430G, LYS183E, LYS183G, LYS324E, LYS324G, LYS404E, LYS404G, LYS423G, MET184E, MET184G, MET298E, MET298G, MET321E, MET321G, MET361E, MET361G, MET398E, MET398G, PHE341E, PRO194G, PRO302E, PRO302G, PRO322E, PRO322G, PRO327E, PRO327G, PRO414G, SER300E, SER300G, SER307E, SER307G, SER318E, SER318G, SER319E, SER349E, SER349G, SER405E, SER405G, SER434E, SER434G, THR187E, THR187G, THR348E, THR348G, THR410E, THR410G, THR420G, THR431E, THR431G, TYR401E, TYR401G, TYR418E, TYR418G, TYR429E, TYR429G, VAL193E, VAL193G, VAL310E, VAL310G, VAL325E, VAL325G, VAL328E, VAL328G, VAL402E, VAL402G, VAL416G
• E-H: ALA231E, ALA231H, ALA292E, ALA292H, ALA304E, ALA30E, ALA30H, ALA313E, ALA313H, ALA337E, ALA337H, ALA350E, ALA350H, ALA353E, ALA353H, ALA99E, ALA99H, ARG296E, ARG296H, ARG29E, ARG29H, ARG314E, ARG314H, ARG40E, ARG40H, ASN132E, ASN132H, ASN142E, ASN142H, ASN237H, ASN293E, ASN293H, ASN326E, ASN326H, ASN334E, ASN334H, ASN33E, ASN33H, ASN343E, ASN343H, ASN359E, ASN359H, ASN368E, ASN368H, ASN378E, ASN378H, ASN386E, ASN386H, ASP10E, ASP10H, ASP344E, ASP344H, ASP93E, ASP93H, GLN26E, GLN26H, GLN315E, GLN315H, GLN335E, GLN335H, GLN339E, GLN339H, GLN355E, GLN355H, GLN371E, GLN371H, GLN96E, GLN96H, GLU109E, GLU109H, GLU32E, GLU32H, GLU331E, GLU331H, GLU352E, GLU352H, GLU362E, GLU362H, GLU385E, GLU385H, GLY100E, GLY100H, GLY305E, GLY317E, GLY317H, GLY342E, GLY342H, GLY354E, GLY354H, GLY38E, GLY38H, GLY97E, GLY97H, GLY98E, GLY98H, HIS42E, HIS42H, ILE103E, ILE28E, ILE28H, ILE320E, ILE347E, ILE347H, ILE36E, ILE36H, ILE370E, ILE375E, ILE375H, ILE95E, ILE95H, LEU12E, LEU12H, LEU189E, LEU189H, LEU236E, LEU236H, LEU297E, LEU297H, LEU345E, LEU345H, LEU358E, LEU358H, LEU365E, LEU365H, LYS282E, LYS282H, LYS324E, LYS324H, LYS381E, LYS381H, MET105E, MET105H, MET321E, MET321H, MET329E, MET329H, MET333E, MET333H, MET361E, MET361H, MET376E, MET376H, PHE11E, PHE11H, PHE338E, PHE338H, PHE341E, PHE341H, PHE34E, PHE34H, PHE356E, PHE356H, PHE366E, PHE366H, PHE367E, PHE367H, PHE380E, PHE380H, PHE383E, PHE383H, PRO312E, PRO312H, PRO316E, PRO316H, PRO327E, PRO327H, PRO330E, PRO330H, PRO35E, PRO35H, PRO363E, PRO363H, PRO94E, PRO94H, SER102E, SER102H, SER289E, SER289H, SER300E, SER300H, SER318E, SER318H, SER319E, SER349E, SER349H, SER351E, SER351H, SER374E, SER374H, SER382E, SER382H, THR101E, THR101H, THR141E, THR141H, THR27E, THR27H, THR31E, THR31H, THR346E, THR346H, THR348E, THR348H, THR377E, THR377H, THR37E, THR37H, TYR39E, TYR39H, VAL232E, VAL232H, VAL25E, VAL25H, VAL325E, VAL325H, VAL328E, VAL328H, VAL332E, VAL332H, VAL336E, VAL336H, VAL340E, VAL340H, VAL360E, VAL360H, VAL364E, VAL364H, VAL379E, VAL379H
• F-G: ALA144F, ALA229F, ALA231F, ALA231G, ALA238F, ALA292F, ALA292G, ALA304G, ALA30F, ALA30G, ALA313F, ALA313G, ALA337F, ALA337G, ALA350F, ALA350G, ALA353F, ALA353G, ALA99F, ALA99G, ARG296F, ARG296G, ARG29F, ARG29G, ARG314F, ARG314G, ARG40F, ARG40G, ASN104F, ASN108F, ASN132F, ASN132G, ASN136F, ASN142F, ASN142G, ASN237F, ASN237G, ASN293F, ASN293G, ASN326F, ASN326G, ASN334F, ASN334G, ASN33F, ASN33G, ASN343F, ASN343G, ASN359F, ASN359G, ASN368F, ASN368G, ASN378F, ASN378G, ASN386F, ASN386G, ASP10F, ASP10G, ASP143F, ASP294F, ASP344F, ASP344G, ASP93F, ASP93G, GLN139F, GLN26F, GLN26G, GLN315F, GLN315G, GLN335F, GLN335G, GLN339F, GLN339G, GLN355F, GLN355G, GLN371F, GLN371G, GLN96F, GLN96G, GLU109G, GLU32F, GLU32G, GLU331F, GLU331G, GLU352F, GLU352G, GLU362F, GLU362G, GLU385F, GLU385G, GLY100F, GLY100G, GLY13F, GLY233F, GLY305F, GLY305G, GLY317F, GLY317G, GLY323G, GLY342F, GLY342G, GLY354F, GLY354G, GLY38F, GLY38G, GLY97F, GLY97G, GLY98F, GLY98G, HIS42F, HIS42G, ILE103F, ILE28G, ILE320F, ILE320G, ILE347F, ILE347G, ILE36F, ILE36G, ILE370G, ILE375F, ILE375G, ILE41G, ILE95F, ILE95G, LEU12F, LEU12G, LEU189F, LEU189G, LEU236F, LEU297F, LEU297G, LEU345F, LEU345G, LEU358F, LEU358G, LEU365F, LEU365G, LYS15F, LYS282F, LYS282G, LYS324F, LYS324G, LYS381F, LYS381G, LYS53F, LYS9F, MET105F, MET105G, MET137F, MET321F, MET321G, MET329F, MET329G, MET333F, MET333G, MET361F, MET361G, MET376F, MET376G, PHE11F, PHE11G, PHE145F, PHE145G, PHE338F, PHE338G, PHE341F, PHE341G, PHE34F, PHE34G, PHE356F, PHE356G, PHE366F, PHE366G, PHE367F, PHE367G, PHE380F, PHE380G, PHE383F, PHE383G, PRO131F, PRO312F, PRO312G, PRO316F, PRO316G, PRO322G, PRO327F, PRO327G, PRO330F, PRO330G, PRO35F, PRO35G, PRO363F, PRO363G, PRO94F, PRO94G, SER102F, SER102G, SER133F, SER138F, SER140F, SER289F, SER289G, SER300F, SER300G, SER318F, SER318G, SER319G, SER349F, SER349G, SER351F, SER351G, SER374F, SER374G, SER382F, SER382G, THR101F, THR101G, THR141F, THR141G, THR230F, THR27F, THR31F, THR31G, THR346F, THR346G, THR348F, THR348G, THR377F, THR377G, THR37F, THR37G, TYR39F, TYR39G, VAL232F, VAL232G, VAL25F, VAL25G, VAL325F, VAL325G, VAL328F, VAL328G, VAL332F, VAL332G, VAL336F, VAL336G, VAL340F, VAL340G, VAL360F, VAL360G, VAL364F, VAL364G, VAL379F, VAL379G, VAL92F
• F-H: ALA192F, ALA192H, ALA292F, ALA292H, ALA299F, ALA299H, ALA304F, ALA304H, ALA353F, ALA353H, ALA411F, ALA411H, ALA421F, ALA421H, ALA422F, ALA422H, ALA425F, ALA425H, ALA428F, ALA428H, ARG186F, ARG186H, ARG296F, ARG296H, ARG303F, ARG303H, ARG397F, ARG397H, ARG426F, ARG426H, ASN293F, ASN293H, ASN326F, ASN326H, ASN394H, ASN413F, ASN413H, ASP191F, ASP191H, ASP294F, ASP294H, ASP344F, ASP344H, GLN190F, GLN190H, GLN315F, GLN315H, GLN335F, GLN335H, GLN355F, GLN355H, GLU308F, GLU308H, GLU331F, GLU331H, GLU352F, GLU352H, GLU400F, GLU400H, GLU403F, GLU403H, GLU419F, GLU419H, GLU427F, GLU427H, GLU433F, GLU433H, GLY185F, GLY185H, GLY301F, GLY301H, GLY305F, GLY305H, GLY323F, GLY323H, GLY407F, GLY407H, GLY417F, GLY417H, GLY432F, GLY432H, HIS188F, HIS188H, ILE309H, ILE320F, ILE320H, ILE406F, ILE406H, ILE408F, ILE408H, ILE409F, ILE409H, ILE412F, ILE412H, ILE435F, ILE435H, LEU189F, LEU189H, LEU295F, LEU295H, LEU297F, LEU297H, LEU306F, LEU306H, LEU311F, LEU311H, LEU345F, LEU345H, LEU424F, LEU424H, LEU430F, LEU430H, LYS183F, LYS183H, LYS324F, LYS324H, LYS404F, LYS404H, LYS423F, LYS423H, MET184F, MET184H, MET298F, MET298H, MET321F, MET321H, MET361F, MET361H, MET398F, MET398H, PRO194F, PRO194H, PRO302F, PRO302H, PRO322F, PRO322H, PRO327F, PRO327H, PRO414F, PRO414H, SER300F, SER300H, SER307F, SER307H, SER318F, SER318H, SER319F, SER319H, SER349F, SER349H, SER405F, SER405H, SER434F, SER434H, THR187F, THR187H, THR348F, THR348H, THR410F, THR410H, THR420F, THR420H, THR431F, THR431H, TYR401F, TYR401H, TYR418F, TYR418H, TYR429F, TYR429H, VAL193F, VAL193H, VAL310F, VAL310H, VAL325F, VAL325H, VAL328F, VAL328H, VAL402F, VAL402H, VAL416F, VAL416H
• G-H: ALA175G, ALA175H, ALA192G, ALA192H, ALA203G, ALA203H, ALA205G, ALA205H, ALA209H, ALA229G, ALA229H, ALA231G, ALA231H, ALA238G, ALA238H, ALA261G, ALA261H, ALA267G, ALA267H, ALA280G, ALA280H, ALA292G, ALA292H, ALA299G, ALA299H, ALA337G, ALA337H, ALA350G, ALA350H, ALA353G, ALA353H, ALA411G, ALA411H, ALA465G, ALA99G, ALA99H, ARG186G, ARG186H, ARG206G, ARG206H, ARG210G, ARG210H, ARG214G, ARG214H, ARG259G, ARG259H, ARG296G, ARG296H, ASN142G, ASN142H, ASN217G, ASN217H, ASN220G, ASN220H, ASN221G, ASN221H, ASN237G, ASN237H, ASN270G, ASN270H, ASN287G, ASN287H, ASN293G, ASN293H, ASN334G, ASN334H, ASN359G, ASN359H, ASN413G, ASN413H, ASN455G, ASN455H, ASP191G, ASP191H, ASP211G, ASP211H, ASP224G, ASP224H, ASP239G, ASP239H, ASP266G, ASP266H, ASP272G, ASP272H, ASP294G, ASP294H, ASP344G, ASP344H, CYS273G, CYS273H, CYS284G, CYS284H, GLN190G, GLN190H, GLN199G, GLN199H, GLN262G, GLN262H, GLN269G, GLN269H, GLN355G, GLN355H, GLU200G, GLU200H, GLU202G, GLU202H, GLU213G, GLU213H, GLU241G, GLU241H, GLU276G, GLU276H, GLU308G, GLU308H, GLU352G, GLU352H, GLU357G, GLU357H, GLU458G, GLU458H, GLY100G, GLY100H, GLY185G, GLY185H, GLY198G, GLY198H, GLY228G, GLY228H, GLY233G, GLY233H, GLY235G, GLY235H, GLY342G, GLY342H, GLY354G, GLY354H, GLY407G, GLY407H, GLY463G, GLY463H, GLY466G, GLY97G, GLY97H, GLY98G, GLY98H, HIS188G, HIS188H, HIS263G, HIS263H, HIS415G, HIS415H, HIS461G, HIS461H, ILE182G, ILE182H, ILE195G, ILE195H, ILE208G, ILE208H, ILE243G, ILE243H, ILE286G, ILE286H, ILE291G, ILE291H, ILE309G, ILE309H, ILE347G, ILE347H, ILE408G, ILE408H, ILE409G, ILE409H, ILE412G, ILE412H, ILE453G, ILE453H, ILE460G, ILE460H, ILE464G, LEU189G, LEU189H, LEU196G, LEU196H, LEU197G, LEU197H, LEU222H, LEU236G, LEU236H, LEU264G, LEU264H, LEU281G, LEU281H, LEU295G, LEU295H, LEU297G, LEU297H, LEU306G, LEU306H, LEU345G, LEU345H, LEU358G, LEU358H, LEU365G, LEU365H, LEU454G, LEU454H, LEU65G, LEU65H, LYS183G, LYS183H, LYS282G, LYS282H, LYS290G, LYS290H, MET172G, MET172H, MET184G, MET184H, MET285G, MET285H, MET288G, MET288H, MET298G, MET298H, MET361G, MET361H, MET459G, MET459H, PHE201G, PHE201H, PHE338G, PHE338H, PHE341G, PHE341H, PHE356G, PHE356H, PRO194G, PRO194H, PRO240G, PRO240H, PRO363G, PRO363H, PRO414G, PRO414H, PRO456H, PRO462G, PRO462H, SER140G, SER140H, SER260H, SER278G, SER278H, SER279G, SER279H, SER289G, SER289H, SER300G, SER300H, SER349G, SER349H, SER351G, SER351H, THR101G, THR101H, THR141G, THR141H, THR187G, THR187H, THR218G, THR218H, THR230G, THR230H, THR234G, THR234H, THR268G, THR268H, THR271G, THR271H, THR275G, THR275H, THR348G, THR348H, THR410G, THR410H, TYR204G, TYR204H, TYR242H, TYR274G, TYR274H, TYR457G, TYR457H, VAL193G, VAL193H, VAL207G, VAL207H, VAL232G, VAL232H, VAL265G, VAL265H, VAL277G, VAL277H, VAL283G, VAL283H, VAL340G, VAL360G, VAL360H, VAL63H