3QWD

crystal structure of clpp from staphylococcus aureus

• Total interactions analyzed: 91
• Total true interactions: 25
• Strongest Interaction:
  • Chains: D-E
  • Int. Res.: 145
  • Norm. En. per Res.: -3.2114
• Hub Node: B(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-13.5193	-7.986	-368.018	-389.5233	146	17	13	15883	1	27	24
A-C	0.0	0.0	-0.0311	-0.0311	3	0	0	14	0	0	0
A-F	0.0	0.0	-7.1067	-7.1067	15	0	0	155	0	0	0
A-G	-48.6648	-11.812	-374.009	-434.4858	144	18	13	15574	1	23	22
B-C	-18.0669	1.8029	-351.099	-367.363	149	20	13	15327	0	31	30
B-D	0.0	0.0	-0.0761	-0.0761	4	0	0	35	0	1	0
B-E	0.0	0.0	-16.3597	-16.3597	15	0	0	339	0	0	1
B-F	0.0	0.0	253.25	253.25	5	8	0	110	0	0	0
B-G	0.0	0.0	-0.0731	-0.0731	4	0	0	38	0	0	1
C-D	-17.7938	7.4373	-341.328	-351.6845	135	17	12	14665	0	22	20
D-E	-41.9822	-31.0361	-392.632	-465.6503	145	20	11	16215	2	33	30
E-F	-22.2293	-10.9065	-359.752	-392.8878	138	18	10	15044	1	22	23
E-J	0.0	0.0	103.469	103.469	35	39	0	628	0	0	0
F-G	-24.0137	7.7661	-338.743	-354.9906	138	15	12	14637	0	21	21
H-I	-28.7486	-29.7074	-341.273	-399.729	143	15	11	14843	2	28	27
H-J	0.0	0.0	-0.0743	-0.0743	4	0	0	38	0	0	0
H-N	-41.5109	-24.4508	-391.505	-457.4666	154	17	13	16303	3	30	32
I-J	-35.5637	-33.7766	-334.162	-403.5023	144	15	12	15161	2	23	22
I-K	0.0	0.0	-0.0665	-0.0665	4	0	0	32	0	0	0
J-K	-22.6853	2.1385	-352.689	-373.2357	137	11	13	15022	0	22	22
J-L	0.0	0.0	-0.0515	-0.0515	4	0	0	29	0	0	0
K-L	-20.7881	-6.1894	-353.312	-380.2895	138	13	12	15012	0	21	21
K-M	0.0	0.0	-0.0462	-0.0462	4	0	0	26	0	0	0
L-M	-12.1864	-7.8568	-344.968	-365.0111	139	12	12	15132	1	21	22
M-N	-13.2302	0.0975	-353.123	-366.2557	140	9	12	14779	0	24	24

Interface residues

• A-B: ALA114B, ALA118B, ALA133A, ALA139A, ALA140A, ALA177B, ALA17A, ALA17B, ALA41A, ALA53A, ALA73A, ALA76A, ALA96B, ALA97B, ARG152A, ARG157A, ARG16A, ARG16B, ARG171B, ARG23A, ARG23B, ASN117B, ASN141A, ASN173B, ASN39A, ASN42A, ASN65B, ASP172B, ASP19A, ASP19B, ASP27B, ASP37A, ASP38A, ASP79A, CYS92B, GLN130B, GLN35B, GLN47A, GLN52A, GLN54A, GLN82A, GLU119B, GLU135A, GLU137A, GLU15B, GLU178B, GLU179B, GLU193B, GLU9A, GLU9B, GLY33A, GLY33B, GLY68B, GLY74A, GLY94B, HIS123B, HIS142A, HIS83A, ILE136A, ILE138A, ILE143A, ILE153A, ILE20A, ILE20B, ILE29A, ILE29B, ILE30A, ILE44A, ILE4A, ILE4B, ILE64B, ILE77A, ILE81A, ILE84A, ILE8A, ILE8B, ILE91B, ILE93B, LEU115B, LEU144A, LEU150A, LEU175B, LEU24A, LEU24B, LEU25A, LEU32A, LEU32B, LEU3B, LEU48A, LEU49A, LEU51A, LYS145A, LYS149A, LYS26A, LYS26B, LYS85A, MET121B, MET190B, MET31A, MET31B, MET95B, PHE102A, PHE113B, PHE174B, PHE50A, PHE75A, PRO116B, PRO125B, PRO192B, PRO5B, PRO67B, PRO86A, SER22A, SER34A, SER34B, SER43A, SER46A, SER56A, SER66B, SER70A, SER98B, THR10A, THR10B, THR134A, THR146A, THR176B, THR194B, THR6A, THR6B, THR72A, THR80A, TYR18A, TYR18B, TYR21A, TYR21B, TYR61B, TYR63B, TYR78A, VAL120B, VAL189B, VAL191B, VAL40A, VAL45A, VAL71A, VAL7A, VAL7B
• A-C: ASN39A, ASN42A, LEU3C
• A-F: ARG112A, ARG157A, ASN39F, ASN42F, GLN160A, GLU182A, GLY159A, GLY184A, HIS1F, LEU3A, LYS164A, SER161A, SER43F, THR158A, TYR183A
• A-G: ALA114A, ALA118A, ALA133G, ALA139G, ALA140G, ALA177A, ALA17A, ALA17G, ALA41G, ALA53G, ALA73G, ALA76G, ALA96A, ALA97A, ARG152G, ARG157G, ARG16A, ARG171A, ARG23A, ARG23G, ASN117A, ASN141G, ASN173A, ASN39G, ASN42G, ASN65A, ASP172A, ASP19A, ASP19G, ASP27A, ASP37G, ASP38G, ASP79G, CYS92A, GLN130A, GLN35A, GLN47G, GLN52G, GLN54G, GLN82G, GLU119A, GLU135G, GLU137G, GLU178A, GLU179A, GLU193A, GLU9A, GLU9G, GLY33A, GLY33G, GLY68A, GLY74G, GLY94A, HIS123A, HIS142G, HIS83G, ILE136G, ILE138G, ILE143G, ILE153G, ILE20A, ILE20G, ILE29A, ILE29G, ILE30G, ILE44G, ILE4A, ILE4G, ILE64A, ILE77G, ILE81G, ILE84G, ILE8A, ILE8G, ILE91A, ILE93A, LEU115A, LEU144G, LEU150G, LEU175A, LEU24A, LEU24G, LEU25G, LEU32A, LEU32G, LEU3A, LEU48G, LEU49G, LEU51G, LYS145G, LYS149G, LYS26A, LYS26G, LYS85G, MET121A, MET190A, MET31A, MET31G, MET95A, PHE102G, PHE113A, PHE174A, PHE50G, PHE75G, PRO116A, PRO125A, PRO192A, PRO5A, PRO67A, PRO86G, SER22G, SER34A, SER34G, SER43G, SER46G, SER56G, SER66A, SER70G, SER98A, THR10A, THR10G, THR134G, THR146G, THR176A, THR194A, THR6A, THR6G, THR72G, THR80G, TYR18A, TYR18G, TYR21A, TYR21G, TYR61A, TYR63A, TYR78G, VAL120A, VAL189A, VAL191A, VAL40G, VAL45G, VAL71G, VAL7A, VAL7G
• B-C: ALA108B, ALA114C, ALA118C, ALA133B, ALA139B, ALA140B, ALA177C, ALA17B, ALA17C, ALA41B, ALA53B, ALA73B, ALA76B, ALA96C, ALA97C, ARG152B, ARG157B, ARG16B, ARG16C, ARG171C, ARG23B, ARG23C, ASN117C, ASN141B, ASN173C, ASN39B, ASN42B, ASN65C, ASP172C, ASP19B, ASP19C, ASP27C, ASP37B, ASP38B, ASP79B, ASP87B, CYS92C, GLN35C, GLN47B, GLN52B, GLN54B, GLN82B, GLU119C, GLU135B, GLU137B, GLU15B, GLU178C, GLU179C, GLU193C, GLU9B, GLU9C, GLY131C, GLY33B, GLY33C, GLY68C, GLY74B, GLY94C, HIS123C, HIS142B, HIS83B, ILE136B, ILE138B, ILE143B, ILE153B, ILE20B, ILE20C, ILE29B, ILE29C, ILE30B, ILE44B, ILE4B, ILE4C, ILE64C, ILE77B, ILE81B, ILE84B, ILE8B, ILE8C, ILE91C, ILE93C, LEU115C, LEU144B, LEU150B, LEU175C, LEU24B, LEU24C, LEU25B, LEU32B, LEU32C, LEU3C, LEU48B, LEU49B, LEU51B, LYS109B, LYS111B, LYS145B, LYS149B, LYS195C, LYS26B, LYS26C, LYS85B, MET121C, MET190C, MET31B, MET31C, MET95C, PHE102B, PHE113C, PHE174C, PHE50B, PHE75B, PRO116C, PRO125C, PRO192C, PRO5C, PRO67C, PRO86B, SER22B, SER34B, SER34C, SER43B, SER46B, SER56B, SER66C, SER70B, SER98C, THR134B, THR146B, THR176C, THR6B, THR6C, THR72B, THR80B, TYR18B, TYR18C, TYR21B, TYR21C, TYR61C, TYR63C, TYR78B, VAL120C, VAL189C, VAL191C, VAL40B, VAL45B, VAL71B, VAL7B, VAL7C, VAL88B
• B-D: ASN39B, ASN42B, LEU3D, SER43B
• B-E: ASP19E, GLN47E, GLY33E, HIS1B, ILE20E, ILE29E, ILE30E, ILE44E, LEU24E, LEU25E, LEU32E, MET31E, SER22E, SER43E, TYR21E
• B-F: HIS1B, ILE20F, ILE4F, PRO5F, THR6F
• B-G: ASN39G, ASN42G, LEU3B, SER43G
• C-D: ALA114D, ALA118D, ALA133C, ALA139C, ALA140C, ALA177D, ALA17C, ALA17D, ALA41C, ALA53C, ALA73C, ALA76C, ALA96D, ALA97D, ARG157C, ARG16C, ARG16D, ARG23C, ARG23D, ASN117D, ASN141C, ASN173D, ASN39C, ASN42C, ASN65D, ASP172D, ASP19C, ASP19D, ASP27D, ASP37C, ASP38C, ASP79C, CYS92D, GLN35D, GLN47C, GLN52C, GLN54C, GLN82C, GLU119D, GLU135C, GLU137C, GLU179D, GLU9C, GLU9D, GLY33C, GLY33D, GLY68D, GLY74C, GLY94D, HIS123D, HIS142C, HIS83C, ILE136C, ILE138C, ILE143C, ILE153C, ILE20C, ILE20D, ILE29C, ILE29D, ILE30C, ILE44C, ILE4C, ILE4D, ILE64D, ILE77C, ILE81C, ILE84C, ILE8C, ILE8D, ILE91D, ILE93D, LEU115D, LEU144C, LEU150C, LEU175D, LEU24C, LEU24D, LEU25C, LEU32C, LEU32D, LEU3D, LEU48C, LEU49C, LEU51C, LYS145C, LYS149C, LYS26C, LYS26D, LYS85C, MET121D, MET190D, MET31C, MET31D, MET95D, PHE102C, PHE113D, PHE174D, PHE50C, PHE75C, PRO116D, PRO125D, PRO192D, PRO5D, PRO67D, SER22C, SER34C, SER34D, SER43C, SER46C, SER66D, SER70C, SER98D, THR134C, THR146C, THR176D, THR6C, THR6D, THR72C, THR80C, TYR18C, TYR18D, TYR21C, TYR21D, TYR61D, TYR63D, TYR78C, VAL120D, VAL189D, VAL191D, VAL40C, VAL45C, VAL71C, VAL7C, VAL7D
• D-E: ALA114E, ALA118E, ALA129E, ALA133D, ALA139D, ALA140D, ALA177E, ALA17D, ALA17E, ALA41D, ALA53D, ALA73D, ALA76D, ALA96E, ALA97E, ARG152D, ARG16D, ARG16E, ARG23D, ARG23E, ASN117E, ASN141D, ASN173E, ASN39D, ASN42D, ASN65E, ASP172E, ASP19D, ASP19E, ASP27E, ASP37D, ASP38D, ASP79D, ASP87D, CYS92E, GLN130E, GLN132E, GLN35E, GLN47D, GLN52D, GLN54D, GLN82D, GLU119E, GLU135D, GLU137D, GLU15E, GLU179E, GLU193E, GLU57D, GLU9D, GLU9E, GLY33D, GLY33E, GLY68E, GLY69E, GLY74D, GLY94E, HIS123E, HIS142D, HIS83D, ILE136D, ILE138D, ILE143D, ILE153D, ILE20D, ILE20E, ILE29D, ILE29E, ILE30D, ILE44D, ILE4D, ILE4E, ILE64E, ILE77D, ILE81D, ILE84D, ILE8D, ILE8E, ILE91E, ILE93E, LEU115E, LEU150D, LEU175E, LEU24D, LEU24E, LEU25D, LEU32E, LEU3E, LEU48D, LEU49D, LEU51D, LYS145D, LYS149D, LYS195E, LYS26D, LYS26E, LYS85D, MET121E, MET190E, MET31D, MET31E, MET95E, PHE102D, PHE113E, PHE174E, PHE50D, PHE75D, PRO116E, PRO125E, PRO192E, PRO5E, PRO67E, PRO86D, SER22D, SER34D, SER34E, SER43D, SER46D, SER56D, SER66E, SER70D, SER98E, THR134D, THR146D, THR176E, THR194E, THR6D, THR6E, THR72D, THR80D, TYR18D, TYR18E, TYR21D, TYR21E, TYR61E, TYR63E, TYR78D, VAL120E, VAL189E, VAL191E, VAL40D, VAL45D, VAL71D, VAL7D, VAL7E
• E-F: ALA114F, ALA118F, ALA129F, ALA133E, ALA139E, ALA140E, ALA177F, ALA17E, ALA41E, ALA53E, ALA73E, ALA76E, ALA96F, ALA97F, ARG152E, ARG157E, ARG16E, ARG171F, ARG23E, ARG23F, ASN117F, ASN141E, ASN173F, ASN39E, ASN42E, ASN65F, ASP172F, ASP19E, ASP19F, ASP27F, ASP37E, ASP38E, ASP79E, CYS92F, GLN130F, GLN35F, GLN47E, GLN52E, GLN54E, GLN82E, GLU119F, GLU135E, GLU137E, GLU15E, GLU178F, GLU179F, GLU193F, GLU9E, GLU9F, GLY33F, GLY68F, GLY74E, GLY94F, HIS123F, HIS142E, HIS83E, ILE136E, ILE138E, ILE143E, ILE153E, ILE20E, ILE20F, ILE29E, ILE29F, ILE30E, ILE44E, ILE4E, ILE4F, ILE64F, ILE77E, ILE81E, ILE84E, ILE8E, ILE8F, ILE91F, ILE93F, LEU115F, LEU144E, LEU150E, LEU175F, LEU24E, LEU24F, LEU25E, LEU32F, LEU48E, LEU49E, LEU51E, LYS145E, LYS149E, LYS26E, LYS26F, LYS85E, MET121F, MET190F, MET31E, MET31F, MET95F, PHE102E, PHE113F, PHE174F, PHE50E, PHE75E, PRO116F, PRO125F, PRO192F, PRO5F, PRO67F, PRO86E, SER22E, SER34F, SER43E, SER46E, SER56E, SER66F, SER70E, SER98F, THR134E, THR146E, THR176F, THR6E, THR6F, THR72E, THR80E, TYR18E, TYR18F, TYR21E, TYR21F, TYR61F, TYR63F, TYR78E, VAL120F, VAL189F, VAL191F, VAL40E, VAL45E, VAL71E, VAL7E, VAL7F
• E-J: ALA105E, ALA114E, ALA118E, ALA177E, ALA180E, ALA96E, ALA97E, ARG112E, ASP187E, CYS92E, GLU119E, GLU178E, GLU179E, GLU182E, GLU188E, GLY184E, HIS1J, ILE122E, ILE186E, ILE91E, LEU104E, LEU115E, LEU175E, LEU185E, LYS181E, MET121E, MET190E, MET95E, PHE113E, SER101E, THR176E, THR90E, TYR183E, VAL120E, VAL189E
• F-G: ALA114G, ALA118G, ALA129G, ALA139F, ALA140F, ALA177G, ALA17G, ALA41F, ALA53F, ALA73F, ALA76F, ALA96G, ALA97G, ARG152F, ARG157F, ARG171G, ARG23F, ARG23G, ASN117G, ASN141F, ASN173G, ASN39F, ASN42F, ASN65G, ASP172G, ASP19F, ASP19G, ASP27G, ASP37F, ASP38F, ASP79F, CYS92G, GLN130G, GLN35G, GLN47F, GLN52F, GLN54F, GLN82F, GLU119G, GLU135F, GLU137F, GLU179G, GLU193G, GLU9F, GLU9G, GLY33F, GLY33G, GLY68G, GLY69G, GLY74F, GLY94G, HIS123G, HIS142F, HIS83F, ILE136F, ILE138F, ILE143F, ILE153F, ILE20F, ILE20G, ILE29F, ILE29G, ILE30F, ILE44F, ILE4F, ILE4G, ILE64G, ILE77F, ILE81F, ILE84F, ILE8F, ILE8G, ILE91G, ILE93G, LEU115G, LEU144F, LEU150F, LEU175G, LEU24F, LEU24G, LEU25F, LEU32G, LEU3G, LEU48F, LEU49F, LEU51F, LYS145F, LYS149F, LYS26F, LYS26G, LYS85F, MET121G, MET190G, MET31F, MET31G, MET95G, PHE102F, PHE113G, PHE174G, PHE50F, PHE75F, PRO116G, PRO125G, PRO192G, PRO5G, PRO67G, PRO86F, SER22F, SER34F, SER34G, SER43F, SER46F, SER66G, SER70F, SER98G, THR10G, THR134F, THR146F, THR176G, THR6F, THR6G, THR72F, THR80F, TYR18F, TYR18G, TYR21F, TYR21G, TYR61G, TYR63G, TYR78F, VAL120G, VAL189G, VAL191G, VAL40F, VAL45F, VAL71F, VAL7F, VAL7G
• H-I: ALA114I, ALA118I, ALA133H, ALA139H, ALA140H, ALA177I, ALA17H, ALA17I, ALA41H, ALA53H, ALA73H, ALA76H, ALA96I, ALA97I, ARG152H, ARG157H, ARG16H, ARG23H, ARG23I, ASN117I, ASN141H, ASN173I, ASN39H, ASN42H, ASN65I, ASP172I, ASP19H, ASP19I, ASP27I, ASP37H, ASP38H, ASP79H, ASP87H, CYS92I, GLN35I, GLN47H, GLN52H, GLN54H, GLN82H, GLU119I, GLU135H, GLU137H, GLU179I, GLU193I, GLU9H, GLU9I, GLY128I, GLY131I, GLY33H, GLY33I, GLY68I, GLY69I, GLY74H, GLY94I, HIS123I, HIS83H, ILE136H, ILE138H, ILE143H, ILE153H, ILE20H, ILE20I, ILE29H, ILE29I, ILE30H, ILE44H, ILE4H, ILE4I, ILE64I, ILE77H, ILE81H, ILE84H, ILE8H, ILE8I, ILE91I, ILE93I, LEU115I, LEU150H, LEU175I, LEU24H, LEU24I, LEU25H, LEU32I, LEU3I, LEU48H, LEU49H, LEU51H, LYS109H, LYS145H, LYS149H, LYS195I, LYS26H, LYS26I, LYS85H, MET121I, MET190I, MET31H, MET31I, MET95I, PHE102H, PHE113I, PHE174I, PHE50H, PHE75H, PRO116I, PRO125I, PRO192I, PRO5I, PRO67I, PRO86H, SER22H, SER34H, SER34I, SER43H, SER46H, SER56H, SER66I, SER70H, SER98I, THR134H, THR146H, THR176I, THR194I, THR6H, THR6I, THR72H, THR80H, TRP196I, TYR18H, TYR18I, TYR21H, TYR21I, TYR61I, TYR63I, TYR78H, VAL120I, VAL189I, VAL191I, VAL40H, VAL45H, VAL71H, VAL7H, VAL7I
• H-J: ASN39H, ASN42H, LEU3J, SER43H
• H-N: ALA108N, ALA114H, ALA118H, ALA133N, ALA139N, ALA140N, ALA177H, ALA17H, ALA17N, ALA41N, ALA53N, ALA73N, ALA76N, ALA96H, ALA97H, ARG152N, ARG157N, ARG16H, ARG16N, ARG171H, ARG23H, ARG23N, ASN117H, ASN141N, ASN173H, ASN39N, ASN42N, ASN65H, ASP172H, ASP19H, ASP19N, ASP27H, ASP37N, ASP38N, ASP59N, ASP79N, ASP87N, CYS92H, GLN130H, GLN35H, GLN47N, GLN52N, GLN54N, GLN82N, GLU119H, GLU135N, GLU137N, GLU178H, GLU179H, GLU193H, GLU202H, GLU57N, GLU9H, GLU9N, GLY33H, GLY33N, GLY68H, GLY74N, GLY94H, HIS123H, HIS142N, HIS198H, HIS83N, ILE136N, ILE138N, ILE143N, ILE153N, ILE20H, ILE20N, ILE29H, ILE29N, ILE30N, ILE44N, ILE4H, ILE4N, ILE64H, ILE77N, ILE81N, ILE84N, ILE8H, ILE8N, ILE91H, ILE93H, LEU115H, LEU144N, LEU150N, LEU175H, LEU24H, LEU24N, LEU25N, LEU32H, LEU32N, LEU3H, LEU48N, LEU49N, LEU51N, LYS111N, LYS145N, LYS149N, LYS195H, LYS26H, LYS26N, LYS85N, MET121H, MET190H, MET31H, MET31N, MET95H, PHE102N, PHE113H, PHE174H, PHE50N, PHE75N, PRO116H, PRO125H, PRO192H, PRO5H, PRO67H, PRO86N, SER197H, SER22N, SER34H, SER34N, SER43N, SER46N, SER56N, SER66H, SER70N, SER98H, THR134N, THR146N, THR176H, THR194H, THR6H, THR6N, THR72N, THR80N, TRP196H, TYR18H, TYR18N, TYR21H, TYR21N, TYR61H, TYR63H, TYR78N, VAL120H, VAL189H, VAL191H, VAL40N, VAL45N, VAL71N, VAL7H, VAL7N, VAL88N
• I-J: ALA114J, ALA118J, ALA129J, ALA133I, ALA139I, ALA140I, ALA177J, ALA17I, ALA17J, ALA41I, ALA53I, ALA73I, ALA76I, ALA96J, ALA97J, ARG152I, ARG157I, ARG16J, ARG23I, ARG23J, ASN117J, ASN141I, ASN173J, ASN39I, ASN42I, ASN65J, ASP172J, ASP19I, ASP19J, ASP27J, ASP37I, ASP38I, ASP79I, CYS92J, GLN124J, GLN130J, GLN132J, GLN35J, GLN47I, GLN52I, GLN54I, GLN82I, GLU119J, GLU135I, GLU137I, GLU179J, GLU193J, GLU9I, GLU9J, GLY131J, GLY33I, GLY33J, GLY68J, GLY69J, GLY74I, GLY94J, HIS123J, HIS142I, HIS83I, ILE136I, ILE138I, ILE143I, ILE153I, ILE20I, ILE20J, ILE29I, ILE29J, ILE30I, ILE44I, ILE4I, ILE4J, ILE64J, ILE77I, ILE81I, ILE84I, ILE8I, ILE8J, ILE91J, ILE93J, LEU115J, LEU150I, LEU175J, LEU24I, LEU24J, LEU25I, LEU32I, LEU32J, LEU3J, LEU48I, LEU49I, LEU51I, LYS145I, LYS149I, LYS26I, LYS26J, LYS85I, MET121J, MET190J, MET31I, MET31J, MET95J, MET99J, PHE102I, PHE113J, PHE174J, PHE50I, PHE75I, PRO116J, PRO125J, PRO192J, PRO5J, PRO67J, PRO86I, SER22I, SER34I, SER34J, SER43I, SER46I, SER56I, SER66J, SER98J, THR134I, THR146I, THR176J, THR194J, THR6I, THR6J, THR72I, THR80I, TYR18I, TYR18J, TYR21I, TYR21J, TYR61J, TYR63J, TYR78I, VAL120J, VAL189J, VAL191J, VAL40I, VAL45I, VAL71I, VAL7I, VAL7J
• I-K: ASN39I, ASN42I, LEU3K, SER43I
• J-K: ALA114K, ALA118K, ALA133J, ALA139J, ALA140J, ALA177K, ALA17J, ALA41J, ALA53J, ALA73J, ALA76J, ALA96K, ALA97K, ARG157J, ARG16J, ARG171K, ARG23J, ARG23K, ASN117K, ASN141J, ASN173K, ASN39J, ASN42J, ASN65K, ASP172K, ASP19J, ASP19K, ASP27K, ASP37J, ASP38J, ASP79J, CYS92K, GLN35K, GLN47J, GLN52J, GLN54J, GLN82J, GLU119K, GLU135J, GLU137J, GLU178K, GLU179K, GLU193K, GLU9J, GLU9K, GLY33J, GLY33K, GLY68K, GLY74J, GLY94K, HIS123K, HIS142J, HIS83J, ILE136J, ILE138J, ILE143J, ILE153J, ILE20J, ILE20K, ILE29J, ILE29K, ILE30J, ILE44J, ILE4J, ILE4K, ILE64K, ILE77J, ILE81J, ILE84J, ILE8J, ILE8K, ILE91K, ILE93K, LEU115K, LEU144J, LEU150J, LEU175K, LEU24J, LEU24K, LEU25J, LEU32J, LEU32K, LEU3K, LEU48J, LEU49J, LEU51J, LYS145J, LYS149J, LYS26J, LYS26K, LYS85J, MET121K, MET190K, MET31J, MET31K, MET95K, PHE102J, PHE113K, PHE174K, PHE50J, PHE75J, PRO116K, PRO125K, PRO192K, PRO5K, PRO67K, PRO86J, SER22J, SER34J, SER34K, SER43J, SER46J, SER66K, SER70J, SER98K, THR134J, THR146J, THR176K, THR6J, THR6K, THR72J, THR80J, TYR18J, TYR18K, TYR21J, TYR21K, TYR61K, TYR63K, TYR78J, VAL120K, VAL189K, VAL191K, VAL40J, VAL45J, VAL71J, VAL7J, VAL7K
• J-L: ASN39J, ASN42J, LEU3L, SER43J
• K-L: ALA114L, ALA118L, ALA133K, ALA139K, ALA140K, ALA177L, ALA41K, ALA53K, ALA73K, ALA76K, ALA96L, ALA97L, ARG152K, ARG157K, ARG171L, ARG23K, ARG23L, ASN117L, ASN141K, ASN173L, ASN39K, ASN42K, ASN65L, ASP172L, ASP19K, ASP19L, ASP27L, ASP37K, ASP38K, ASP79K, CYS92L, GLN35L, GLN47K, GLN52K, GLN54K, GLN82K, GLU119L, GLU135K, GLU137K, GLU178L, GLU179L, GLU193L, GLU9K, GLU9L, GLY131L, GLY33K, GLY33L, GLY68L, GLY74K, GLY94L, HIS123L, HIS142K, HIS83K, ILE136K, ILE138K, ILE143K, ILE153K, ILE20K, ILE20L, ILE29K, ILE29L, ILE30K, ILE44K, ILE4K, ILE4L, ILE64L, ILE77K, ILE81K, ILE84K, ILE8K, ILE8L, ILE91L, ILE93L, LEU115L, LEU144K, LEU150K, LEU175L, LEU24K, LEU24L, LEU25K, LEU32K, LEU32L, LEU3L, LEU48K, LEU49K, LEU51K, LYS145K, LYS149K, LYS26K, LYS26L, LYS85K, MET121L, MET190L, MET31K, MET31L, MET95L, PHE102K, PHE113L, PHE174L, PHE50K, PHE75K, PRO116L, PRO125L, PRO192L, PRO5L, PRO67L, PRO86K, SER22K, SER34K, SER34L, SER43K, SER46K, SER56K, SER66L, SER70K, SER98L, THR134K, THR146K, THR176L, THR6K, THR6L, THR72K, THR80K, TYR18K, TYR18L, TYR21K, TYR21L, TYR61L, TYR63L, TYR78K, VAL120L, VAL189L, VAL191L, VAL40K, VAL45K, VAL71K, VAL7K, VAL7L
• K-M: ASN39K, ASN42K, LEU3M, SER43K
• L-M: ALA114M, ALA118M, ALA129M, ALA139L, ALA140L, ALA177M, ALA17M, ALA41L, ALA53L, ALA73L, ALA76L, ALA96M, ALA97M, ARG152L, ARG171M, ARG23L, ARG23M, ASN117M, ASN141L, ASN173M, ASN39L, ASN42L, ASN65M, ASP172M, ASP19L, ASP19M, ASP27M, ASP37L, ASP38L, ASP79L, CYS92M, GLN130M, GLN35M, GLN47L, GLN52L, GLN54L, GLN82L, GLU119M, GLU135L, GLU137L, GLU178M, GLU179M, GLU193M, GLU9L, GLU9M, GLY33L, GLY33M, GLY68M, GLY74L, GLY94M, HIS123M, HIS142L, HIS83L, ILE136L, ILE138L, ILE143L, ILE153L, ILE20L, ILE20M, ILE29L, ILE29M, ILE30L, ILE44L, ILE4L, ILE4M, ILE64M, ILE77L, ILE81L, ILE84L, ILE8L, ILE8M, ILE91M, ILE93M, LEU115M, LEU144L, LEU150L, LEU175M, LEU24L, LEU24M, LEU25L, LEU32L, LEU32M, LEU3M, LEU48L, LEU49L, LEU51L, LYS145L, LYS149L, LYS26L, LYS26M, LYS85L, MET121M, MET190M, MET31L, MET31M, MET95M, PHE102L, PHE113M, PHE174M, PHE50L, PHE75L, PRO116M, PRO125M, PRO192M, PRO5M, PRO67M, PRO86L, SER22L, SER34L, SER34M, SER43L, SER46L, SER56L, SER66M, SER70L, SER98M, THR134L, THR146L, THR176M, THR194M, THR6L, THR6M, THR72L, THR80L, TYR18L, TYR18M, TYR21L, TYR21M, TYR61M, TYR63M, TYR78L, VAL120M, VAL189M, VAL191M, VAL40L, VAL45L, VAL71L, VAL7L, VAL7M
• M-N: ALA114N, ALA118N, ALA129N, ALA133M, ALA139M, ALA140M, ALA177N, ALA17M, ALA17N, ALA41M, ALA53M, ALA73M, ALA76M, ALA96N, ALA97N, ARG157M, ARG16M, ARG16N, ARG171N, ARG23M, ARG23N, ASN117N, ASN141M, ASN173N, ASN39M, ASN42M, ASN65N, ASP172N, ASP19M, ASP19N, ASP27N, ASP37M, ASP38M, ASP79M, CYS92N, GLN35N, GLN47M, GLN52M, GLN54M, GLN82M, GLU119N, GLU135M, GLU137M, GLU178N, GLU179N, GLU193N, GLU9M, GLU9N, GLY33M, GLY33N, GLY68N, GLY74M, GLY94N, HIS123N, HIS142M, HIS83M, ILE136M, ILE138M, ILE143M, ILE153M, ILE20M, ILE20N, ILE29M, ILE29N, ILE30M, ILE44M, ILE4M, ILE4N, ILE64N, ILE77M, ILE81M, ILE84M, ILE8M, ILE8N, ILE91N, ILE93N, LEU115N, LEU144M, LEU150M, LEU175N, LEU24M, LEU24N, LEU25M, LEU32N, LEU3N, LEU48M, LEU49M, LEU51M, LYS145M, LYS149M, LYS26M, LYS26N, LYS85M, MET121N, MET190N, MET31M, MET31N, MET95N, PHE102M, PHE113N, PHE174N, PHE50M, PHE75M, PRO116N, PRO125N, PRO192N, PRO5N, PRO67N, PRO86M, SER22M, SER34M, SER34N, SER43M, SER46M, SER56M, SER66N, SER70M, SER98N, THR134M, THR146M, THR176N, THR6M, THR6N, THR72M, THR80M, TYR18M, TYR18N, TYR21M, TYR21N, TYR61N, TYR63N, TYR78M, VAL120N, VAL189N, VAL191N, VAL40M, VAL45M, VAL71M, VAL7M, VAL7N