3QTK

the crystal structure of chemically synthesized vegf-a

• Total interactions analyzed: 15
• Total true interactions: 12
• Strongest Interaction:
  • Chains: A-F
  • Int. Res.: 22
  • Norm. En. per Res.: -6.2791
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-D	-111.7171	-62.9257	684.232	509.5892	118	25	10	14765	4	20	21
A-B	0.0	-0.6735	-16.2499	-16.9234	13	0	0	805	0	5	4
A-C	0.0	0.0	-0.0104	-0.0104	8	0	0	10	0	5	3
A-F	-45.2086	-1.2804	-91.6506	-138.1396	22	5	0	2780	1	15	14
D-C	0.0	0.0	-1.3723	-1.3723	4	0	0	122	0	2	3
D-F	0.0	-13.4396	-29.162	-42.6016	16	0	0	1104	0	15	13
B-C	-94.6104	-51.5615	740.31	594.138	120	28	8	15717	4	20	22
B-E	-34.1942	-32.5045	-92.7227	-159.4214	29	4	0	3239	3	16	12
B-F	-2.1828	8.6045	-19.1967	-12.775	24	0	0	873	0	3	7
C-E	-20.5011	-10.8516	-76.7665	-108.1193	35	3	0	2933	0	13	8
C-F	0.0	-5.0051	-1.2771	-6.2822	12	0	0	240	0	6	1
E-F	-122.99	-63.0459	759.032	572.9961	119	28	10	15691	4	17	21

Interface residues

• A-D: ARG16A, ARG16D, ARG49D, ARG75A, ARG75D, ASN55A, ASN55D, ASN68A, ASP12A, ASP12D, ASP27A, ASP27D, ASP56A, ASP56D, CYS19A, CYS19D, CYS44A, CYS44D, CYS50A, CYS50D, CYS53A, CYS53D, CYS54A, CYS54D, CYS61A, CYS61D, GLN15A, GLN15D, GLN72A, GLN72D, GLN82D, GLN91A, GLN91D, GLU23A, GLU23D, GLU57A, GLU57D, GLU6D, GLU86A, GLU86D, GLY51A, GLY51D, GLY52A, GLY52D, GLY85A, GLY85D, HIS20A, HIS20D, ILE22A, ILE22D, ILE28A, ILE28D, ILE39A, ILE39D, ILE69A, ILE69D, ILE73A, ILE73D, ILE76A, ILE76D, ILE84A, ILE84D, LEU25A, LEU25D, LEU47A, LEU47D, LYS41A, LYS41D, LYS9A, LYS9D, MET11A, MET11D, MET48A, MET48D, MET71A, MET71D, MET74A, MET74D, MET87A, MET87D, PHE10A, PHE10D, PHE29A, PHE29D, PHE40A, PHE40D, PHE89A, PHE89D, PRO21D, PRO42A, PRO42D, PRO46A, PRO46D, PRO78A, SER17A, SER17D, SER43A, SER43D, SER88A, SER88D, THR24A, THR24D, THR70A, THR70D, TYR14A, TYR14D, TYR18A, TYR18D, VAL13A, VAL13D, VAL26A, VAL26D, VAL45A, VAL45D, VAL7A, VAL7D, VAL8A, VAL8D
• A-B: ASP12B, ASP34A, GLN15B, GLN30A, GLU35A, ILE36A, LYS9B, MET11B, PHE10B, PHE29A, PRO33A, TYR14B, TYR32A
• A-C: ASP102A, ASP34A, GLN72C, ILE36A, ILE84C, LYS41C, MET48C, MET74C
• A-F: ARG98F, ASP102F, GLN80A, GLU35A, GLU37A, GLU60F, GLY58F, GLY81A, HIS79A, ILE36A, ILE39A, ILE76A, LEU59F, LYS100F, LYS101F, LYS77A, PHE29A, PHE40A, PRO78A, PRO99F, TYR38A, VAL62F
• D-C: GLU37D, GLU6C, HIS5C, ILE36D
• D-F: ARG98F, ASP56D, GLU57D, GLU65F, GLU66F, GLU96F, GLY58D, LEU59D, LYS100D, LYS101F, LYS94F, PRO63F, PRO99D, PRO99F, THR64F, VAL62F
• B-C: ARG16B, ARG16C, ARG49C, ARG75B, ARG75C, ASN55B, ASN55C, ASN68B, ASN68C, ASP12B, ASP12C, ASP27B, ASP27C, ASP56B, ASP56C, CYS19B, CYS19C, CYS44B, CYS44C, CYS50B, CYS50C, CYS53B, CYS53C, CYS54B, CYS54C, CYS61B, CYS61C, GLN15B, GLN15C, GLN72B, GLN72C, GLN82C, GLN91C, GLU23B, GLU23C, GLU57B, GLU57C, GLU6B, GLU6C, GLU86B, GLU86C, GLY51B, GLY51C, GLY52B, GLY52C, GLY85B, GLY85C, HIS20B, HIS20C, HIS5C, ILE22B, ILE22C, ILE28B, ILE28C, ILE39B, ILE39C, ILE69B, ILE69C, ILE73B, ILE73C, ILE76B, ILE76C, ILE84B, ILE84C, LEU25B, LEU25C, LEU47B, LEU47C, LYS41B, LYS41C, LYS9B, LYS9C, MET11B, MET11C, MET48C, MET71B, MET71C, MET74B, MET74C, MET87B, MET87C, PHE10B, PHE10C, PHE29B, PHE29C, PHE40B, PHE40C, PHE89B, PHE89C, PRO21C, PRO42B, PRO42C, PRO46B, PRO46C, SER17B, SER17C, SER43B, SER43C, SER88B, SER88C, THR24B, THR24C, THR70B, THR70C, TYR14B, TYR14C, TYR18B, TYR18C, TYR38B, TYR38C, VAL13B, VAL13C, VAL26B, VAL26C, VAL45B, VAL45C, VAL7B, VAL7C, VAL8B, VAL8C
• B-E: ARG75E, ARG98B, ASN55B, ASP102B, ASP56B, CYS54B, CYS97B, GLN80E, GLN82E, GLU57B, GLU60B, GLY58B, GLY81E, GLY85E, HIS79E, HIS83E, ILE39E, ILE76E, ILE84E, LEU59B, LYS100B, LYS101B, LYS41E, LYS77E, MET74E, PHE40E, PRO42E, PRO78E, PRO99B
• B-F: ARG98B, ASN55B, ASN55F, ASP102B, ASP56B, ASP56F, CYS54F, CYS97B, GLN15F, GLU57F, GLY58B, GLY58F, LEU59B, LEU59F, LYS100B, LYS101B, MET11B, MET11F, PHE10F, PRO99B, PRO99F, TYR14B, TYR14F, TYR18B
• C-E: ASP27C, ASP27E, GLN30C, GLN30E, GLN80C, GLN80E, GLU35C, GLU35E, GLU37C, GLU37E, HIS79C, HIS79E, ILE28C, ILE28E, ILE36C, ILE36E, ILE39C, ILE39E, ILE76C, ILE76E, LYS77C, LYS77E, PHE29C, PHE29E, PHE40C, PHE40E, PRO33C, PRO33E, PRO78C, PRO78E, SER43C, SER43E, TYR32C, TYR38C, TYR38E
• C-F: ASP56F, GLN80C, GLN82C, GLU57F, GLY58F, HIS79C, ILE76C, LEU59F, LYS100F, LYS41C, MET74C, PRO78C
• E-F: ARG16E, ARG16F, ARG49E, ARG49F, ARG75E, ARG75F, ASN55E, ASN55F, ASN68E, ASP12E, ASP12F, ASP27E, ASP27F, ASP56E, ASP56F, CYS19E, CYS19F, CYS44E, CYS44F, CYS50E, CYS50F, CYS53E, CYS53F, CYS54E, CYS54F, CYS61E, CYS61F, GLN15E, GLN15F, GLN72E, GLN72F, GLN82F, GLN91E, GLN91F, GLU23E, GLU23F, GLU57E, GLU57F, GLU6E, GLU6F, GLU86E, GLU86F, GLY51E, GLY51F, GLY52E, GLY52F, GLY85E, GLY85F, HIS20E, HIS20F, ILE22E, ILE22F, ILE28E, ILE28F, ILE39E, ILE39F, ILE69E, ILE69F, ILE73E, ILE73F, ILE76E, ILE84E, ILE84F, LEU25E, LEU25F, LEU47E, LEU47F, LYS41E, LYS41F, LYS9E, LYS9F, MET11E, MET11F, MET48E, MET48F, MET71E, MET71F, MET74E, MET74F, MET87E, MET87F, PHE10E, PHE10F, PHE29F, PHE40E, PHE40F, PHE89E, PHE89F, PRO21E, PRO21F, PRO42E, PRO42F, PRO46E, PRO46F, SER17E, SER17F, SER43E, SER43F, SER88E, SER88F, THR24E, THR24F, THR70E, THR70F, TYR14E, TYR14F, TYR18E, TYR18F, TYR38F, VAL13E, VAL13F, VAL26E, VAL26F, VAL45E, VAL45F, VAL7E, VAL7F, VAL8E, VAL8F