3QS9

crystal structure of a human flt3 ligand-receptor ternary complex

• Total interactions analyzed: 28
• Total true interactions: 12
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 68
  • Norm. En. per Res.: -5.1614
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-57.7916	-15.5259	-270.085	-343.4025	68	15	11	9995	0	10	15
A-C	0.0	4.1836	-32.5803	-28.3967	27	0	3	1749	0	1	3
A-D	0.0	3.9486	-26.0843	-22.1357	36	3	0	1733	0	5	6
A-E	-11.2945	-0.6723	-97.0523	-109.0191	58	7	0	4221	1	16	21
B-C	0.0	9.7857	-23.1011	-13.3155	35	6	0	1728	0	5	6
B-D	0.0	5.538	-0.014	5.524	2	0	0	1	0	0	1
B-F	-10.9086	-0.7563	-96.6755	-108.3404	58	7	0	4215	1	16	21
B-H	0.0	0.0	-0.2344	-0.2344	5	0	0	52	0	0	1
C-D	-58.9667	-14.6482	-277.361	-350.9759	68	9	11	10047	0	10	14
C-H	-17.9787	-0.6785	-96.9772	-115.6344	58	5	0	4241	1	16	21
D-E	0.0	0.0	-0.1104	-0.1104	5	0	0	34	0	0	1
D-G	-10.9441	-0.8081	-96.4483	-108.2005	58	6	0	4210	1	16	21

Interface residues

• A-B: ALA64A, ALA64B, ARG20A, ARG20B, ARG59A, ARG59B, ASN100A, ASN100B, ASP24A, ASP24B, ASP29A, ASP29B, GLN28A, GLN28B, GLN69A, GLN69B, GLN98A, GLN98B, GLU21A, GLU21B, GLY65A, GLY65B, GLY70A, GLY70B, ILE101A, ILE101B, LEU105A, LEU105B, LEU22A, LEU22B, LEU26A, LEU26B, LEU27A, LEU27B, LEU60A, LEU60B, LEU71A, LEU71B, LEU72A, LEU72B, LYS61A, LYS61B, LYS67A, LYS67B, MET57A, MET57B, MET68A, MET68B, PRO31A, PRO31B, SER102A, SER102B, SER23A, SER23B, SER66A, SER66B, THR62A, THR62B, TRP56A, TRP56B, TYR25A, TYR25B, TYR30A, TYR30B, VAL32A, VAL32B, VAL63A, VAL63B
• A-C: ARG59A, ARG59C, ARG95A, ARG95C, GLN98A, GLN98C, LEU94A, LEU94C, PHE96A, PHE96C, PRO31A, PRO31C, PRO90A, PRO90C, SER36A, SER36C, THR33A, THR33C, THR99A, THR99C, TRP56A, TRP56C, VAL34A, VAL63A, VAL63C, VAL97A, VAL97C
• A-D: ALA86A, ARG103D, ARG55A, ARG59A, ARG95D, ASN100D, ASN37D, ASN76A, ASP29D, ASP3A, CYS85A, CYS93D, GLN54A, GLN98D, GLU58A, HIS80A, LEU60A, LEU94D, LYS61A, LYS84A, PHE81A, PHE87A, PHE96D, PRO31D, PRO89A, PRO90A, SER36D, SER92D, THR33D, THR62A, THR83A, THR99D, TRP56A, VAL63A, VAL82A, VAL97D
• A-E: ARG307E, ARG311E, ARG74A, ASN278E, ASN306E, ASN76A, ASP14A, ASP180E, GLN179E, GLN54A, GLN7A, GLU223E, GLU299E, GLU58A, GLU73A, GLU78A, GLY280E, GLY282E, HIS222E, HIS279E, HIS80A, HIS8A, ILE119A, ILE11A, ILE310E, ILE312E, ILE79A, LEU112A, LEU283E, LYS116A, LYS18A, LYS61A, LYS84A, MET300E, MET309E, PHE15A, PHE225E, PHE281E, PHE298E, PHE6A, PHE81A, PRO10A, SER12A, SER13A, SER301E, SER304E, SER333E, SER5A, SER9A, THR120A, THR302E, THR305E, THR308E, THR77A, THR83A, TYR303E, VAL17A, VAL82A
• B-C: ALA86C, ARG103B, ARG55C, ARG59C, ARG95B, ASN100B, ASN37B, ASN76C, ASP29B, ASP3C, CYS85C, CYS93B, GLN54C, GLN98B, GLU58C, HIS80C, LEU60C, LEU94B, LYS61C, LYS84C, PHE81C, PHE87C, PHE96B, PRO31B, PRO89C, SER36B, SER92B, THR33B, THR62C, THR83C, THR99B, TRP56C, VAL63C, VAL82C, VAL97B
• B-D: ASP29B, ASP29D
• B-F: ARG307F, ARG311F, ARG74B, ASN278F, ASN306F, ASN76B, ASP14B, ASP180F, GLN179F, GLN54B, GLN7B, GLU223F, GLU299F, GLU58B, GLU73B, GLU78B, GLY280F, GLY282F, HIS222F, HIS279F, HIS80B, HIS8B, ILE119B, ILE11B, ILE310F, ILE312F, ILE79B, LEU112B, LEU283F, LYS116B, LYS18B, LYS61B, LYS84B, MET300F, MET309F, PHE15B, PHE225F, PHE281F, PHE298F, PHE6B, PHE81B, PRO10B, SER12B, SER13B, SER301F, SER304F, SER333F, SER5B, SER9B, THR120B, THR302F, THR305F, THR308F, THR77B, THR83B, TYR303F, VAL17B, VAL82B
• B-H: ARG307H, ARG95B, ASN37B, SER36B, VAL97B
• C-D: ALA64C, ALA64D, ARG20C, ARG20D, ARG59C, ARG59D, ASN100C, ASN100D, ASP24C, ASP24D, ASP29C, ASP29D, GLN28C, GLN28D, GLN69C, GLN69D, GLN98C, GLN98D, GLU21C, GLU21D, GLY65C, GLY65D, GLY70C, GLY70D, ILE101C, ILE101D, LEU105C, LEU105D, LEU22C, LEU22D, LEU26C, LEU26D, LEU27C, LEU27D, LEU60C, LEU60D, LEU71C, LEU71D, LEU72C, LEU72D, LYS61C, LYS61D, LYS67C, LYS67D, MET57C, MET57D, MET68C, MET68D, PRO31C, PRO31D, SER102C, SER102D, SER23C, SER23D, SER66C, SER66D, THR62C, THR62D, TRP56C, TRP56D, TYR25C, TYR25D, TYR30C, TYR30D, VAL32C, VAL32D, VAL63C, VAL63D
• C-H: ARG307H, ARG311H, ARG74C, ASN278H, ASN306H, ASN76C, ASP14C, ASP180H, GLN179H, GLN54C, GLN7C, GLU223H, GLU299H, GLU58C, GLU73C, GLU78C, GLY280H, GLY282H, HIS222H, HIS279H, HIS80C, HIS8C, ILE119C, ILE11C, ILE310H, ILE312H, ILE79C, LEU112C, LEU283H, LYS116C, LYS18C, LYS61C, LYS84C, MET300H, MET309H, PHE15C, PHE225H, PHE281H, PHE298H, PHE6C, PHE81C, PRO10C, SER12C, SER13C, SER301H, SER304H, SER333H, SER5C, SER9C, THR120C, THR302H, THR305H, THR308H, THR77C, THR83C, TYR303H, VAL17C, VAL82C
• D-E: ARG307E, ARG95D, ASN37D, SER36D, VAL97D
• D-G: ARG307G, ARG311G, ARG74D, ASN278G, ASN306G, ASN76D, ASP14D, ASP180G, GLN179G, GLN54D, GLN7D, GLU223G, GLU299G, GLU58D, GLU73D, GLU78D, GLY280G, GLY282G, HIS222G, HIS279G, HIS80D, HIS8D, ILE119D, ILE11D, ILE310G, ILE312G, ILE79D, LEU112D, LEU283G, LYS116D, LYS18D, LYS61D, LYS84D, MET300G, MET309G, PHE15D, PHE225G, PHE281G, PHE298G, PHE6D, PHE81D, PRO10D, SER12D, SER13D, SER301G, SER304G, SER333G, SER5D, SER9D, THR120D, THR302G, THR305G, THR308G, THR77D, THR83D, TYR303G, VAL17D, VAL82D