3QS7

crystal structure of a human flt3 ligand-receptor ternary complex

• Total interactions analyzed: 28
• Total true interactions: 12
• Strongest Interaction:
  • Chains: C-D
  • Int. Res.: 63
  • Norm. En. per Res.: -3.8916
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-22.5068	0.0	-187.785	-210.2918	62	10	9	7855	0	12	13
A-C	0.0	0.0	-12.8022	-12.8022	14	0	0	544	0	2	4
A-D	0.0	-0.2961	-44.2364	-44.5325	44	1	1	2216	0	14	9
A-E	-15.0077	32.2927	-147.26	-129.975	64	8	0	4866	0	17	26
B-C	-8.4745	1.0151	-52.7135	-60.1729	43	4	1	2599	0	14	10
B-F	-14.3899	4.3389	-138.212	-148.2629	62	4	0	4428	1	17	23
C-D	-43.0721	0.0	-202.101	-245.1731	63	11	9	7956	0	11	11
C-G	-15.1224	4.7675	-140.039	-150.3939	62	5	0	4448	1	18	23
D-E	0.0	0.0	-0.0027	-0.0027	3	0	0	3	0	2	1
D-H	-14.5134	-0.5656	-115.785	-130.864	59	6	0	4215	1	19	23
E-F	0.0	0.0	-0.047	-0.047	6	0	0	18	0	6	7
F-H	-15.8274	0.0	-44.6775	-60.5049	33	2	4	1505	0	8	11

Interface residues

• A-B: ALA64A, ALA64B, ARG20A, ARG20B, ARG59A, ARG59B, ASN100A, ASN100B, ASP24A, ASP24B, ASP29A, ASP29B, GLN28A, GLN28B, GLN69A, GLN69B, GLU21A, GLU21B, GLY65A, GLY65B, GLY70A, GLY70B, ILE101A, ILE101B, LEU105B, LEU22A, LEU22B, LEU26A, LEU26B, LEU27A, LEU27B, LEU60A, LEU60B, LEU71A, LEU71B, LEU72A, LEU72B, LYS61A, LYS61B, LYS67A, LYS67B, MET68A, MET68B, PRO31A, PRO31B, SER102A, SER23A, SER23B, SER66A, SER66B, THR62A, THR62B, TRP56A, TRP56B, TYR25A, TYR25B, TYR30A, TYR30B, VAL32A, VAL32B, VAL63A, VAL63B
• A-C: ALA64A, ALA64C, ARG59A, ARG59C, GLN69A, GLN69C, GLU58A, GLU58C, LYS61A, LYS61C, THR62A, THR62C, VAL63A, VAL63C
• A-D: ALA35D, ALA86A, ARG103D, ARG49D, ARG59A, ARG95D, ASN100D, ASN37D, ASP29D, ASP3A, ASP40D, CYS132D, CYS85A, GLN106D, GLN111D, GLN133D, GLN28D, GLN2A, GLN88A, GLN98D, GLU107D, GLU110D, GLU58A, HIS-1A, HIS80A, LEU104D, LEU128A, LEU38D, LEU94D, LYS84A, MET0A, PHE87A, PHE96D, PRO89A, SER-2A, SER102D, SER36D, THR108D, THR1A, THR62A, THR83A, THR99D, VAL34D, VAL97D
• A-E: ALA16A, ARG307E, ARG311E, ARG74A, ASN278E, ASN306E, ASN76A, ASP14A, ASP180E, GLN179E, GLN54A, GLN7A, GLU223E, GLU299E, GLU58A, GLU73A, GLU78A, GLY280E, GLY282E, HIS-1A, HIS222E, HIS276E, HIS279E, HIS80A, HIS8A, ILE119A, ILE11A, ILE310E, ILE312E, ILE79A, LEU112A, LEU224E, LEU283E, LYS18A, LYS334E, LYS84A, MET300E, MET309E, PHE15A, PHE225E, PHE281E, PHE298E, PHE6A, PHE81A, PRO10A, SER-2A, SER12A, SER13A, SER301E, SER304E, SER332E, SER333E, SER5A, SER9A, THR120A, THR302E, THR305E, THR308E, THR77A, THR83A, TYR303E, VAL17A, VAL75A, VAL82A
• B-C: ALA35B, ALA86C, ARG103B, ARG49B, ARG95B, ASN100B, ASN37B, ASP29B, ASP3C, ASP40B, CYS132B, CYS85C, GLN106B, GLN111B, GLN133B, GLN28B, GLN2C, GLN88C, GLN98B, GLU107B, GLU110B, GLU58C, HIS-1C, HIS80C, LEU128C, LEU38B, LEU94B, LYS84C, MET0C, PHE87C, PHE96B, PRO31B, PRO89C, SER-2C, SER36B, THR1C, THR33B, THR62C, THR83C, THR99B, VAL34B, VAL82C, VAL97B
• B-F: ALA16B, ARG307F, ARG311F, ARG74B, ASN278F, ASN306F, ASN76B, ASP14B, ASP180F, GLN179F, GLN54B, GLN7B, GLU223F, GLU299F, GLU58B, GLU73B, GLU78B, GLY280F, GLY282F, HIS222F, HIS276F, HIS279F, HIS80B, HIS8B, ILE119B, ILE11B, ILE310F, ILE312F, ILE79B, LEU112B, LEU224F, LEU283F, LYS18B, LYS334F, LYS61B, LYS84B, MET300F, MET309F, PHE15B, PHE225F, PHE281F, PHE6B, PHE81B, PRO10B, SER12B, SER13B, SER301F, SER304F, SER332F, SER333F, SER5B, SER9B, THR120B, THR302F, THR305F, THR308F, THR77B, THR83B, TYR303F, VAL17B, VAL75B, VAL82B
• C-D: ALA64C, ALA64D, ARG20C, ARG20D, ARG59C, ARG59D, ASN100C, ASN100D, ASP24C, ASP24D, ASP29C, ASP29D, GLN28C, GLN28D, GLN69C, GLN69D, GLN98C, GLU21C, GLU21D, GLY65C, GLY65D, GLY70C, GLY70D, ILE101C, ILE101D, LEU105C, LEU22C, LEU22D, LEU26C, LEU26D, LEU27C, LEU27D, LEU60C, LEU60D, LEU71C, LEU71D, LEU72C, LEU72D, LYS61C, LYS61D, LYS67C, LYS67D, MET68C, MET68D, PRO31C, PRO31D, SER102D, SER23C, SER23D, SER66C, SER66D, THR62C, THR62D, TRP56C, TRP56D, TYR25C, TYR25D, TYR30C, TYR30D, VAL32C, VAL32D, VAL63C, VAL63D
• C-G: ARG307G, ARG311G, ARG74C, ASN278G, ASN306G, ASN76C, ASP14C, ASP180G, GLN179G, GLN54C, GLN7C, GLU223G, GLU299G, GLU58C, GLU73C, GLU78C, GLY280G, GLY282G, HIS222G, HIS276G, HIS279G, HIS80C, HIS8C, ILE119C, ILE11C, ILE310G, ILE312G, ILE79C, LEU112C, LEU224G, LEU283G, LYS18C, LYS334G, LYS84C, MET300G, MET309G, PHE15C, PHE225G, PHE281G, PHE298G, PHE6C, PHE81C, PRO10C, SER-2C, SER12C, SER13C, SER301G, SER304G, SER332G, SER333G, SER5C, SER9C, THR120C, THR302G, THR305G, THR308G, THR77C, THR83C, TYR303G, VAL17C, VAL75C, VAL82C
• D-E: ARG103D, ARG307E, GLN106D
• D-H: ALA16D, ARG307H, ARG311H, ARG74D, ASN278H, ASN306H, ASN76D, ASP14D, ASP180H, GLN179H, GLN54D, GLN7D, GLU223H, GLU299H, GLU58D, GLU73D, GLU78D, GLY280H, GLY282H, HIS222H, HIS279H, HIS80D, HIS8D, ILE119D, ILE11D, ILE310H, ILE312H, ILE79D, LEU112D, LEU224H, LEU283H, LYS18D, LYS84D, MET300H, MET309H, PHE15D, PHE225H, PHE281H, PHE298H, PHE6D, PHE81D, PRO10D, SER12D, SER13D, SER301H, SER304H, SER333H, SER5D, SER9D, THR120D, THR302H, THR305H, THR308H, THR77D, THR83D, TYR303H, VAL17D, VAL75D, VAL82D
• E-F: ASN408E, GLN363F, HIS411F, LYS388E, LYS410F, TYR364F
• F-H: ARG161F, ARG387H, ASN162F, ASN235H, ASP84F, GLU135F, GLU191F, GLU191H, GLU236H, HIS109F, ILE160F, LEU164F, LEU164H, LEU165F, LEU165H, LEU237F, LEU237H, PHE390H, PRO190F, PRO190H, PRO391H, SER389H, SER86F, THR136F, THR163F, THR163H, THR167F, THR167H, TYR166F, TYR166H, VAL189F, VAL189H, VAL85F