3QQU

cocrystal structure of unphosphorylated igf with pyrimidine 8

• Total interactions analyzed: 6
• Total true interactions: 2
• Strongest Interaction:
  • Chains: B-D
  • Int. Res.: 63
  • Norm. En. per Res.: -2.3125
• Hub Node: B(2)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
B-C	-15.1135	19.5724	-162.109	-157.6501	82	20	6	8675	0	26	38
B-D	-13.3365	-21.731	-110.618	-145.6855	63	9	1	4229	2	17	16

Interface residues

• B-C: ALA1035B, ALA1036B, ALA1048B, ALA1048C, ARG1039B, ARG1039C, ARG1041B, ARG1131C, ARG993B, ASN1033B, ASN1046B, ASN1046C, ASN1124C, ASN1126C, ASP1132C, ASP1150C, ASP987B, ASP987C, GLN1068B, GLN1070B, GLU1034B, GLU1040B, GLU1040C, GLU1043B, GLU1043C, GLU1047B, GLU1047C, GLU1053B, GLU1053C, GLU988B, GLU988C, GLU990B, GLU990C, GLY1064C, GLY1069B, GLY1152C, HIS1130C, ILE1042B, ILE1042C, LEU1045B, LEU1045C, LEU1062C, LEU1073C, LEU1123C, LYS1052B, LYS1052C, LYS1127C, MET1038B, MET1038C, MET1051C, MET1153C, PHE1007C, PHE1044B, PHE1044C, PHE1054C, PHE1128C, PHE1151C, PHE1186C, PRO1071B, PRO986B, PRO986C, SER1037B, SER1049B, SER1049C, SER1067B, SER1067C, THR1072B, THR1187C, THR1188C, TRP989B, TRP989C, TYR1122C, VAL1050B, VAL1050C, VAL1065B, VAL1065C, VAL1066B, VAL1066C, VAL1074C, VAL1129C, VAL1185C, VAL985B
• B-D: ALA1102D, ALA1203D, ALA1206D, ARG1000B, ARG1026B, ARG1081B, ARG1089B, ARG1092B, ARG993B, ASN1233D, ASP1156B, ASP1232D, ASP1236D, CYS1234D, GLN1004B, GLU1001B, GLU1012B, GLU1034B, GLU1201D, GLU1265D, GLU1266D, GLU1268D, GLY1003B, GLY1013B, ILE1029B, ILE1157B, ILE1202D, LEU1002B, LEU1073B, LEU1078B, LEU1088D, LEU1091D, LEU1101D, LEU1106D, LEU1199D, LEU1205D, LEU1238D, LYS1108D, MET1009B, MET1109D, MET1242D, MET1267D, MET998B, PRO1071B, PRO1093D, PRO1103D, PRO1104D, PRO1231D, PRO1235D, PRO1269D, SER1086B, SER1090B, SER1105D, SER1107D, SER999B, THR1031B, THR1080B, THR1204D, THR997B, TRP1200D, TYR1011B, VAL1010B, VAL1014B