3QMU

bovine glutamate dehydrogenase complexed with epicatechin-3-gallate (ecg)

• Total interactions analyzed: 66
• Total true interactions: 35
• Strongest Interaction:
  • Chains: K-L
  • Int. Res.: 9
  • Norm. En. per Res.: -4.3746
• Hub Node: A(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-29.891	-6.5008	-366.534	-402.9257	202	37	8	18376	2	51	61
A-C	0.0	0.0	-15.6595	-15.6595	9	0	1	603	0	0	0
A-D	-38.4638	-38.8269	-347.077	-424.3677	143	36	4	16084	4	36	40
A-E	0.0	16.0158	-60.8822	-44.8664	44	0	0	3271	0	20	22
A-F	-22.7001	-19.7091	-386.325	-428.7343	203	58	9	19315	3	56	67
A-I	0.0	0.0	-0.0017	-0.0017	2	0	0	1	0	0	2
A-J	0.0	0.0	-0.0636	-0.0636	3	0	0	26	0	5	2
B-C	0.0	15.3298	-73.4767	-58.1469	51	2	0	3635	0	22	23
B-D	0.0	0.0	-3.8407	-3.8407	9	0	0	161	0	0	0
B-E	-43.9457	-39.0827	-332.845	-415.8734	138	40	3	15392	4	35	40
B-F	-25.6305	-22.7422	-387.095	-435.4677	191	44	7	18004	2	50	57
B-I	0.0	-8.9961	-4.6704	-13.6665	14	0	0	549	0	13	12
C-D	-44.7309	-20.1986	-362.406	-427.3355	190	40	7	17598	2	49	58
C-E	-44.4617	-16.597	-415.819	-476.8777	202	59	9	19321	3	57	68
C-F	-36.4783	-40.1183	-341.359	-417.9557	144	25	4	16333	4	34	39
D-E	-36.3861	-8.5709	-361.018	-405.975	196	36	8	18184	2	52	61
D-F	0.0	14.926	-72.8216	-57.8956	50	1	0	3608	0	22	23
E-F	0.0	0.0	-7.772	-7.772	7	1	0	262	0	0	0
F-I	0.0	0.0	-4.1672	-4.1672	19	3	0	555	0	2	5
F-J	0.0	0.0	-0.0678	-0.0678	2	0	0	13	0	1	1
G-H	-24.2478	-8.9816	-347.288	-380.5173	193	31	7	17869	3	53	59
G-I	0.0	0.0	-31.6147	-31.6147	10	3	1	1004	0	0	0
G-J	-35.5119	-44.361	-328.71	-408.583	144	33	3	15622	4	36	42
G-K	0.0	14.9719	-62.6052	-47.6333	46	0	0	3245	0	16	19
G-L	-38.5126	-23.0743	-388.361	-449.9479	200	50	9	19152	3	55	63
H-I	0.0	5.0236	-61.3399	-56.3163	45	0	0	3272	0	20	21
H-J	0.0	0.0	-1.3236	-1.3236	4	0	0	78	0	0	0
H-K	-51.5468	-42.0881	-339.201	-432.8359	142	35	3	15650	4	36	42
H-L	-28.0884	-16.7467	-339.922	-384.7571	192	55	8	18110	3	51	59
I-J	-27.8266	-20.924	-382.64	-431.3906	191	49	8	18350	3	51	60
I-K	-18.8522	-20.6968	-375.893	-415.442	199	54	9	18721	3	55	63
I-L	-30.5073	-39.1377	-342.562	-412.207	149	20	5	16234	4	36	40
J-K	-21.6499	-8.903	-340.007	-370.5599	195	39	7	17904	3	52	59
J-L	0.0	5.0088	-63.9398	-58.931	47	0	0	3353	0	20	21
K-L	-7.6636	0.0	-31.7079	-39.3715	9	5	1	923	0	0	0

Interface residues

• A-B: ALA153B, ALA180A, ALA184A, ALA194A, ALA194B, ALA196B, ALA434B, ALA443A, ALA443B, ALA454B, ALA496B, ARG146A, ARG147A, ARG174A, ARG217B, ARG35B, ARG396A, ARG403A, ARG403B, ARG419A, ARG439B, ARG459B, ARG491B, ARG66A, ARG86B, ASN139A, ASN193A, ASN193B, ASN225B, ASN387B, ASN388A, ASN390A, ASN390B, ASN406A, ASN406B, ASN494B, ASP119B, ASP138A, ASP163B, ASP181A, ASP191A, ASP191B, ASP404A, ASP438B, ASP447B, CYS115B, GLN205A, GLN414A, GLN414B, GLN437B, GLN463B, GLN81B, GLN84B, GLU140A, GLU142A, GLU173A, GLU175A, GLU224B, GLU384B, GLU402A, GLU402B, GLU415A, GLU418A, GLU435B, GLU445A, GLU445B, GLU458B, GLU495B, GLY156B, GLY159B, GLY161B, GLY188A, GLY206A, GLY207A, GLY395A, GLY395B, GLY426B, GLY442A, GLY452B, GLY497B, HIS189A, HIS195A, HIS209A, HIS221B, HIS391A, HIS408A, HIS408B, HIS450B, HIS57B, HIS85B, ILE144A, ILE179A, ILE187A, ILE192A, ILE192B, ILE203A, ILE208B, ILE428B, ILE430A, ILE430B, ILE440B, ILE448B, ILE65A, LEU386B, LEU389A, LEU389B, LEU397A, LEU409A, LEU409B, LEU410A, LEU410B, LEU417A, LEU417B, LEU453B, LYS143A, LYS154B, LYS155B, LYS201A, LYS33B, LYS400A, LYS420A, LYS420B, LYS446B, LYS488B, MET150A, MET176A, MET411A, MET411B, MET457B, PHE122B, PHE157B, PHE383B, PHE399A, PHE399B, PHE421B, PHE436A, PHE436B, PHE490B, PHE500B, PRO121B, PRO160B, PRO202A, PRO429A, PRO429B, PRO432B, PRO88B, SER177A, SER185A, SER204A, SER393A, SER405A, SER405B, SER412A, SER416A, SER441A, SER441B, SER444A, SER444B, SER451B, SER460B, THR137A, THR182A, THR186A, THR34B, THR379B, THR398A, THR398B, THR427A, THR427B, THR433B, THR456B, THR499B, THR501B, THR87B, TRP178A, TRP385B, TYR136A, TYR183A, TYR183B, TYR190A, TYR382B, TYR394A, TYR394B, TYR401A, TYR407A, TYR407B, TYR455B, TYR493B, VAL117B, VAL118B, VAL120B, VAL162B, VAL164B, VAL380B, VAL392A, VAL413A, VAL413B, VAL431B, VAL449B, VAL489B, VAL492B, VAL498B
• A-C: PHE500A, PHE500C, THR499A, THR499C, THR501A, THR501C, TYR190A, TYR190C, VAL498A
• A-D: ALA153A, ALA153D, ALA80A, ALA80D, ARG146A, ARG146D, ARG147A, ARG147D, ARG44A, ARG44D, ARG46A, ARG46D, ARG50A, ARG50D, ARG66A, ARG66D, ARG67A, ARG79A, ARG79D, ASN139D, ASN43A, ASN43D, ASN56A, ASN56D, ASP163A, ASP163D, ASP69A, ASP69D, CYS55A, CYS55D, CYS89A, CYS89D, GLN40A, GLN40D, GLN81A, GLN81D, GLN84A, GLN84D, GLU140D, GLU142D, GLU151A, GLU151D, GLU36A, GLU36D, GLU73A, GLU73D, GLU76A, GLU76D, GLY156A, GLY156D, GLY497A, GLY497D, GLY70A, GLY70D, GLY77A, GLY77D, HIS57A, HIS57D, HIS82A, ILE144D, ILE158A, ILE158D, ILE187A, ILE48A, ILE48D, ILE51A, ILE51D, ILE52A, ILE52D, ILE65A, ILE65D, ILE75A, ILE75D, LEU141D, LEU152A, LEU152D, LEU49A, LEU49D, LEU59A, LEU59D, LEU61A, LEU61D, LYS105A, LYS105D, LYS143A, LYS143D, LYS154A, LYS154D, LYS155A, LYS155D, LYS53A, LYS53D, MET150A, MET150D, PHE148A, PHE148D, PHE157A, PHE157D, PHE500A, PHE500D, PHE63A, PHE63D, PRO54A, PRO54D, PRO64A, PRO64D, SER47A, SER47D, SER60A, SER60D, SER62A, SER62D, SER71A, SER71D, THR145D, THR149A, THR149D, THR182A, THR182D, THR186A, THR186D, THR499A, THR499D, THR501A, THR501D, TRP72A, TRP72D, TYR493A, TYR493D, TYR78A, TYR78D, VAL101A, VAL101D, VAL162A, VAL162D, VAL45A, VAL45D, VAL498A, VAL498D, VAL58A, VAL58D, VAL74A, VAL74D
• A-E: ALA153A, ALA153E, ALA184A, ALA184E, ARG147A, ARG147E, ARG66A, ARG66E, ASN139A, ASN139E, ASP181A, ASP181E, GLU142A, GLU142E, GLU151A, GLU151E, GLY156A, GLY156E, GLY188A, GLY188E, HIS189A, HIS189E, ILE187A, ILE187E, LYS143A, LYS143E, LYS154A, LYS154E, LYS155A, LYS155E, MET150A, MET150E, SER185A, SER185E, THR182A, THR182E, THR186A, THR186E, TRP72A, TRP72E, TYR183A, TYR183E, TYR190A, TYR190E
• A-F: ALA153A, ALA180F, ALA184F, ALA194A, ALA194F, ALA196A, ALA434A, ALA443A, ALA443F, ALA454A, ALA496A, ARG146F, ARG147F, ARG174F, ARG35A, ARG396F, ARG403A, ARG403F, ARG419F, ARG439A, ARG44A, ARG459A, ARG491A, ARG66F, ARG86A, ASN139F, ASN193A, ASN193F, ASN387A, ASN387F, ASN388F, ASN390A, ASN390F, ASN406A, ASN406F, ASN494A, ASP119A, ASP138F, ASP163A, ASP181F, ASP191A, ASP191F, ASP404F, ASP438A, ASP447A, CYS115A, GLN205F, GLN297F, GLN414A, GLN414F, GLN437A, GLN463A, GLN81A, GLN84A, GLU140F, GLU142F, GLU173F, GLU175F, GLU224A, GLU384A, GLU402A, GLU402F, GLU415F, GLU418F, GLU435A, GLU445A, GLU445F, GLU458A, GLU495A, GLY156A, GLY159A, GLY161A, GLY206F, GLY207F, GLY395A, GLY395F, GLY426A, GLY442A, GLY442F, GLY452A, GLY497A, HIS189F, HIS195F, HIS209F, HIS221A, HIS391F, HIS408A, HIS408F, HIS450A, HIS57A, HIS85A, ILE144F, ILE192A, ILE192F, ILE203F, ILE208A, ILE428A, ILE430A, ILE430F, ILE440A, ILE448A, ILE65F, LEU141F, LEU296F, LEU386A, LEU389A, LEU389F, LEU397F, LEU409A, LEU409F, LEU410A, LEU410F, LEU417A, LEU417F, LEU453A, LYS134F, LYS143F, LYS154A, LYS155A, LYS201F, LYS33A, LYS400F, LYS420A, LYS420F, LYS446A, LYS488A, MET150F, MET176F, MET411A, MET411F, MET457A, PHE122A, PHE383A, PHE399A, PHE399F, PHE421A, PHE436A, PHE436F, PHE490A, PHE500A, PRO121A, PRO160A, PRO202F, PRO429A, PRO429F, PRO432A, PRO88A, SER177F, SER185F, SER204F, SER393F, SER405A, SER405F, SER412F, SER416F, SER441F, SER444A, SER444F, SER451A, SER460A, THR137F, THR182F, THR186F, THR34A, THR379A, THR398A, THR398F, THR427A, THR427F, THR433A, THR456A, THR499A, THR501A, THR87A, TRP178F, TRP385A, TYR136F, TYR183A, TYR183F, TYR190F, TYR382A, TYR394A, TYR394F, TYR401F, TYR407A, TYR407F, TYR455A, TYR493A, VAL117A, VAL118A, VAL120A, VAL162A, VAL164A, VAL378A, VAL380A, VAL392F, VAL413A, VAL413F, VAL431A, VAL449A, VAL489A, VAL492A, VAL498A
• A-I: ALA230A, GLU290I
• A-J: GLY422J, LYS423J, THR37A
• B-C: ALA153B, ALA153C, ALA184B, ALA184C, ARG147B, ARG147C, ARG66B, ARG66C, ASN139B, ASN139C, ASP138B, ASP138C, ASP181B, ASP181C, GLU140B, GLU140C, GLU142B, GLU142C, GLU151B, GLU151C, GLY156B, GLY156C, GLY188B, GLY188C, HIS189B, HIS189C, ILE187B, ILE187C, LEU152B, LYS143B, LYS143C, LYS154B, LYS154C, LYS155B, LYS155C, MET150B, MET150C, PHE157B, PHE157C, SER185B, SER185C, THR182B, THR182C, THR186B, THR186C, TRP72B, TRP72C, TYR183B, TYR183C, TYR190B, TYR190C
• B-D: HIS189B, HIS189D, PHE500B, PHE500D, THR499B, THR501B, THR501D, TYR190B, TYR190D
• B-E: ALA153B, ALA153E, ALA80B, ALA80E, ARG146B, ARG146E, ARG147B, ARG147E, ARG44B, ARG44E, ARG46B, ARG46E, ARG50B, ARG50E, ARG66B, ARG66E, ARG79B, ARG79E, ASN43B, ASN43E, ASN56B, ASN56E, ASP163B, ASP163E, ASP69B, ASP69E, CYS55B, CYS55E, CYS89B, CYS89E, GLN40B, GLN40E, GLN81B, GLN81E, GLN84B, GLN84E, GLU151B, GLU151E, GLU36B, GLU36E, GLU73B, GLU73E, GLU76B, GLU76E, GLY156B, GLY156E, GLY497B, GLY497E, GLY70B, GLY70E, GLY77B, GLY77E, HIS57B, HIS57E, HIS82E, ILE144E, ILE158B, ILE158E, ILE187B, ILE187E, ILE48B, ILE48E, ILE51B, ILE51E, ILE52B, ILE52E, ILE65B, ILE65E, ILE75B, ILE75E, LEU152B, LEU152E, LEU49B, LEU49E, LEU59B, LEU59E, LEU61B, LEU61E, LYS105B, LYS105E, LYS143B, LYS143E, LYS154B, LYS154E, LYS155B, LYS155E, LYS53B, LYS53E, MET150B, MET150E, PHE148B, PHE148E, PHE157B, PHE157E, PHE500B, PHE500E, PHE63B, PHE63E, PRO54B, PRO54E, PRO64B, PRO64E, SER185B, SER47B, SER47E, SER60B, SER60E, SER62B, SER62E, SER71B, SER71E, THR149B, THR149E, THR182B, THR182E, THR186B, THR186E, THR499B, THR499E, THR501B, THR501E, TRP72B, TRP72E, TYR493B, TYR78B, TYR78E, VAL101B, VAL101E, VAL162B, VAL162E, VAL45B, VAL45E, VAL498B, VAL498E, VAL58B, VAL58E, VAL74B, VAL74E
• B-F: ALA153F, ALA180B, ALA184B, ALA194B, ALA194F, ALA196F, ALA434F, ALA443B, ALA443F, ALA454F, ALA496F, ARG146B, ARG147B, ARG174B, ARG35F, ARG396B, ARG403B, ARG403F, ARG419B, ARG439F, ARG459F, ARG491F, ARG86F, ASN139B, ASN193B, ASN193F, ASN387F, ASN388B, ASN390B, ASN390F, ASN406B, ASN406F, ASN494F, ASP119F, ASP138B, ASP163F, ASP181B, ASP191B, ASP191F, ASP404B, ASP438F, ASP447F, CYS115F, GLN205B, GLN414B, GLN414F, GLN437F, GLN463F, GLN81F, GLN84F, GLU140B, GLU142B, GLU173B, GLU175B, GLU384F, GLU402B, GLU402F, GLU415B, GLU418B, GLU418F, GLU435F, GLU445B, GLU445F, GLU458F, GLU495F, GLY156F, GLY159F, GLY161F, GLY206B, GLY207B, GLY395B, GLY395F, GLY426F, GLY452F, GLY497F, HIS189B, HIS195B, HIS209B, HIS221F, HIS391B, HIS408B, HIS408F, HIS450F, HIS57F, HIS85F, ILE179B, ILE192B, ILE192F, ILE203B, ILE208F, ILE428F, ILE430B, ILE430F, ILE440F, ILE448F, LEU386F, LEU389B, LEU389F, LEU397B, LEU409B, LEU409F, LEU410B, LEU410F, LEU417B, LEU417F, LEU453F, LYS143B, LYS154F, LYS155F, LYS201B, LYS33F, LYS400B, LYS420B, LYS420F, LYS446F, LYS488F, MET150B, MET176B, MET411B, MET411F, MET457F, PHE122F, PHE157F, PHE383F, PHE399B, PHE399F, PHE421F, PHE436B, PHE436F, PHE490F, PHE500F, PRO121F, PRO160F, PRO202B, PRO429B, PRO429F, PRO432F, PRO88F, SER177B, SER185B, SER204B, SER393B, SER405B, SER405F, SER412B, SER416B, SER441B, SER444B, SER444F, SER451F, SER460F, THR137B, THR182B, THR186B, THR34F, THR379F, THR398B, THR398F, THR427B, THR427F, THR433F, THR456F, THR499F, THR501F, THR87F, TRP178B, TRP385F, TYR136B, TYR183F, TYR190B, TYR382F, TYR394F, TYR401B, TYR407B, TYR407F, TYR455F, TYR493F, VAL117F, VAL118F, VAL120F, VAL162F, VAL164F, VAL380F, VAL392B, VAL413B, VAL413F, VAL431F, VAL449F, VAL489F, VAL492F, VAL498F
• B-I: ARG338I, ARG419B, ASP318I, GLU316I, GLY422B, HIS424B, ILE271I, LYS340I, LYS423B, PHE421B, PRO283I, TRP281I, TYR310I, VAL317I
• C-D: ALA153C, ALA180D, ALA184D, ALA194C, ALA194D, ALA196C, ALA434C, ALA443C, ALA443D, ALA454C, ALA496C, ARG146D, ARG174D, ARG35C, ARG396D, ARG403C, ARG403D, ARG419D, ARG439C, ARG459C, ARG491C, ARG86C, ASN139D, ASN193C, ASN193D, ASN387C, ASN388D, ASN390C, ASN390D, ASN406C, ASN406D, ASN494C, ASP119C, ASP138D, ASP163C, ASP181D, ASP191C, ASP191D, ASP404D, ASP438C, ASP447C, CYS115C, GLN205D, GLN414C, GLN414D, GLN437C, GLN463C, GLN81C, GLN84C, GLU142D, GLU173D, GLU175D, GLU384C, GLU402C, GLU402D, GLU415D, GLU418D, GLU435C, GLU445C, GLU445D, GLU458C, GLU495C, GLY156C, GLY159C, GLY161C, GLY206D, GLY207D, GLY395C, GLY395D, GLY426C, GLY452C, GLY497C, HIS189D, HIS195D, HIS209D, HIS221C, HIS391D, HIS408C, HIS408D, HIS450C, HIS57C, HIS85C, ILE179D, ILE192C, ILE192D, ILE203D, ILE208C, ILE428C, ILE430C, ILE430D, ILE440C, ILE448C, LEU386C, LEU389C, LEU389D, LEU397D, LEU409C, LEU409D, LEU410C, LEU410D, LEU417C, LEU417D, LEU453C, LYS134D, LYS143D, LYS154C, LYS155C, LYS201D, LYS33C, LYS400D, LYS420C, LYS420D, LYS446C, LYS488C, MET150D, MET176D, MET411C, MET411D, MET457C, PHE122C, PHE157C, PHE383C, PHE399C, PHE399D, PHE421C, PHE436C, PHE436D, PHE490C, PHE500C, PRO121C, PRO160C, PRO202D, PRO429C, PRO429D, PRO432C, PRO88C, SER177D, SER185D, SER204D, SER393D, SER405C, SER405D, SER412D, SER416D, SER441C, SER441D, SER444C, SER444D, SER451C, SER460C, THR137D, THR182D, THR186D, THR34C, THR379C, THR398C, THR398D, THR427C, THR427D, THR433C, THR456C, THR499C, THR501C, THR87C, TRP178D, TRP385C, TYR136D, TYR183C, TYR190D, TYR382C, TYR394C, TYR401D, TYR407C, TYR407D, TYR455C, TYR493C, VAL117C, VAL118C, VAL120C, VAL162C, VAL164C, VAL380C, VAL392D, VAL413C, VAL413D, VAL431C, VAL449C, VAL489C, VAL492C, VAL498C
• C-E: ALA153E, ALA180C, ALA184C, ALA194C, ALA194E, ALA196E, ALA434E, ALA443C, ALA443E, ALA454E, ALA496E, ARG146C, ARG174C, ARG35E, ARG396C, ARG403C, ARG403E, ARG419C, ARG439E, ARG44E, ARG459E, ARG491E, ARG86E, ASN139C, ASN193C, ASN193E, ASN225E, ASN387C, ASN387E, ASN388C, ASN390C, ASN390E, ASN406C, ASN406E, ASN494E, ASP119E, ASP138C, ASP163E, ASP181C, ASP191C, ASP191E, ASP404C, ASP438E, ASP447E, CYS115E, GLN205C, GLN297C, GLN414C, GLN414E, GLN437E, GLN463E, GLN81E, GLN84E, GLU142C, GLU173C, GLU224E, GLU36E, GLU384E, GLU402C, GLU402E, GLU415C, GLU418C, GLU418E, GLU435E, GLU445C, GLU445E, GLU458E, GLU495E, GLY156E, GLY159E, GLY161E, GLY206C, GLY207C, GLY395C, GLY395E, GLY426E, GLY442C, GLY442E, GLY452E, GLY497E, HIS189C, HIS195C, HIS209C, HIS221E, HIS391C, HIS408C, HIS408E, HIS450E, HIS57E, HIS85E, ILE179C, ILE187C, ILE192C, ILE192E, ILE203C, ILE208E, ILE428E, ILE430C, ILE430E, ILE440E, ILE448E, LEU296C, LEU386E, LEU389C, LEU389E, LEU397C, LEU409C, LEU409E, LEU410C, LEU410E, LEU417C, LEU417E, LEU453E, LYS134C, LYS143C, LYS154E, LYS155E, LYS201C, LYS33E, LYS400C, LYS420C, LYS420E, LYS446E, LYS488E, MET150C, MET176C, MET411C, MET411E, MET457E, PHE122E, PHE157E, PHE383E, PHE399C, PHE399E, PHE421E, PHE436C, PHE436E, PHE490E, PHE500E, PRO121E, PRO160E, PRO202C, PRO429C, PRO429E, PRO432E, PRO88E, SER177C, SER185C, SER204C, SER393C, SER405C, SER405E, SER412C, SER416C, SER441C, SER444C, SER444E, SER451E, SER460E, THR137C, THR182C, THR186C, THR34E, THR379E, THR398C, THR398E, THR427C, THR427E, THR433E, THR456E, THR499E, THR501E, THR87E, TRP178C, TRP385E, TYR136C, TYR183C, TYR183E, TYR190C, TYR382E, TYR394C, TYR394E, TYR401C, TYR407C, TYR407E, TYR455E, TYR493E, VAL117E, VAL118E, VAL120E, VAL162E, VAL164E, VAL378E, VAL380E, VAL392C, VAL413C, VAL413E, VAL431E, VAL449E, VAL489E, VAL492E, VAL498E
• C-F: ALA153C, ALA153F, ALA80C, ALA80F, ARG146C, ARG146F, ARG147C, ARG147F, ARG44C, ARG44F, ARG46C, ARG46F, ARG50C, ARG50F, ARG66C, ARG66F, ARG67C, ARG79C, ARG79F, ASN139F, ASN43C, ASN43F, ASN56C, ASN56F, ASP163C, ASP163F, ASP181C, ASP69C, ASP69F, CYS55C, CYS55F, CYS89C, CYS89F, GLN40C, GLN40F, GLN81C, GLN81F, GLN84C, GLN84F, GLU142F, GLU151C, GLU151F, GLU36C, GLU36F, GLU73C, GLU73F, GLU76C, GLU76F, GLY156C, GLY156F, GLY497C, GLY497F, GLY70C, GLY70F, GLY77C, GLY77F, HIS57C, HIS57F, ILE144F, ILE158C, ILE158F, ILE48C, ILE48F, ILE51C, ILE51F, ILE52C, ILE52F, ILE65C, ILE65F, ILE75C, ILE75F, LEU152C, LEU152F, LEU49C, LEU49F, LEU59C, LEU59F, LEU61C, LEU61F, LYS105C, LYS105F, LYS143C, LYS143F, LYS154C, LYS154F, LYS155C, LYS155F, LYS53C, LYS53F, MET150C, MET150F, PHE148C, PHE148F, PHE157C, PHE157F, PHE500C, PHE500F, PHE63C, PHE63F, PRO54C, PRO54F, PRO64C, PRO64F, SER185C, SER185F, SER47C, SER47F, SER60C, SER60F, SER62C, SER62F, SER71C, SER71F, THR145C, THR145F, THR149C, THR149F, THR182C, THR182F, THR186C, THR186F, THR499C, THR499F, THR501C, THR501F, TRP72C, TRP72F, TYR183C, TYR493C, TYR493F, TYR78C, TYR78F, VAL101C, VAL101F, VAL162C, VAL162F, VAL45C, VAL45F, VAL498C, VAL498F, VAL58C, VAL58F, VAL74C, VAL74F
• D-E: ALA153D, ALA180E, ALA184E, ALA194D, ALA194E, ALA196D, ALA434D, ALA443D, ALA443E, ALA454D, ALA496D, ARG146E, ARG147E, ARG174E, ARG217D, ARG35D, ARG396E, ARG403D, ARG403E, ARG419E, ARG439D, ARG459D, ARG491D, ARG86D, ASN139E, ASN193D, ASN193E, ASN225D, ASN387D, ASN388E, ASN390D, ASN390E, ASN406D, ASN406E, ASN494D, ASP119D, ASP138E, ASP163D, ASP181E, ASP191D, ASP191E, ASP404E, ASP438D, ASP447D, CYS115D, GLN205E, GLN414D, GLN414E, GLN437D, GLN463D, GLN81D, GLN84D, GLU140E, GLU142E, GLU173E, GLU175E, GLU224D, GLU384D, GLU402D, GLU402E, GLU415E, GLU418E, GLU435D, GLU445D, GLU445E, GLU458D, GLU495D, GLY156D, GLY159D, GLY161D, GLY188E, GLY206E, GLY207E, GLY395D, GLY395E, GLY426D, GLY442D, GLY442E, GLY452D, GLY497D, HIS189E, HIS195E, HIS209E, HIS221D, HIS391E, HIS408D, HIS408E, HIS450D, HIS57D, HIS85D, ILE144E, ILE192D, ILE192E, ILE203E, ILE208D, ILE428D, ILE430D, ILE440D, ILE448D, LEU386D, LEU389D, LEU389E, LEU397E, LEU409D, LEU409E, LEU410D, LEU410E, LEU417D, LEU417E, LEU453D, LYS143E, LYS154D, LYS155D, LYS201E, LYS33D, LYS400E, LYS420D, LYS420E, LYS446D, LYS488D, MET150E, MET176E, MET411D, MET411E, MET457D, PHE122D, PHE157D, PHE383D, PHE399D, PHE399E, PHE421D, PHE436D, PHE436E, PHE490D, PHE500D, PRO121D, PRO160D, PRO202E, PRO429D, PRO429E, PRO432D, PRO88D, SER177E, SER185E, SER204E, SER393E, SER405D, SER405E, SER412E, SER416E, SER441E, SER444D, SER444E, SER451D, SER460D, THR137E, THR182E, THR186E, THR34D, THR379D, THR398D, THR398E, THR427D, THR427E, THR433D, THR456D, THR499D, THR501D, THR87D, TRP178E, TRP385D, TYR136E, TYR183D, TYR190E, TYR382D, TYR394D, TYR394E, TYR401E, TYR407D, TYR407E, TYR455D, TYR493D, VAL117D, VAL118D, VAL120D, VAL162D, VAL164D, VAL380D, VAL392E, VAL413D, VAL413E, VAL431D, VAL449D, VAL489D, VAL492D, VAL498D
• D-F: ALA153D, ALA153F, ALA184D, ALA184F, ARG147D, ARG147F, ARG66D, ARG66F, ASN139D, ASN139F, ASP138D, ASP138F, ASP181D, ASP181F, GLU140D, GLU140F, GLU142D, GLU142F, GLU151D, GLU151F, GLY156D, GLY156F, GLY188D, GLY188F, HIS189D, HIS189F, ILE187D, ILE187F, LEU152D, LYS143D, LYS143F, LYS154D, LYS154F, LYS155D, LYS155F, MET150D, MET150F, PHE157D, SER185D, SER185F, THR182D, THR182F, THR186D, THR186F, TRP72D, TRP72F, TYR183D, TYR183F, TYR190D, TYR190F
• E-F: PHE500E, PHE500F, THR499E, THR501E, THR501F, TYR190E, TYR190F
• F-I: ALA434F, ASN282I, ASP284I, GLN414F, GLN437F, GLU418F, GLY425F, GLY426F, HIS424F, ILE309I, ILE428F, ILE430F, LYS306I, LYS308I, PRO283I, THR427F, TRP281I, TYR310I, VAL431F
• F-J: GLN297F, LYS423J
• G-H: ALA153H, ALA180G, ALA184G, ALA194G, ALA194H, ALA196H, ALA434H, ALA443G, ALA443H, ALA454H, ALA496H, ARG146G, ARG174G, ARG217H, ARG35H, ARG396G, ARG403G, ARG403H, ARG419G, ARG439H, ARG459H, ARG491H, ARG86H, ASN139G, ASN193G, ASN193H, ASN225H, ASN387H, ASN388G, ASN390G, ASN390H, ASN406G, ASN406H, ASN494H, ASP119H, ASP138G, ASP163H, ASP181G, ASP191G, ASP191H, ASP404G, ASP438H, ASP447H, CYS115H, GLN205G, GLN414G, GLN414H, GLN437H, GLN463H, GLN81H, GLN84H, GLU142G, GLU173G, GLU224H, GLU384H, GLU402G, GLU402H, GLU415G, GLU418G, GLU435H, GLU445G, GLU445H, GLU458H, GLU495H, GLY156H, GLY159H, GLY161H, GLY206G, GLY207G, GLY395G, GLY395H, GLY426H, GLY442G, GLY442H, GLY452H, GLY497H, HIS189G, HIS195G, HIS209G, HIS221H, HIS391G, HIS408G, HIS408H, HIS450H, HIS57H, HIS85H, ILE179G, ILE192G, ILE192H, ILE203G, ILE208H, ILE428H, ILE430G, ILE430H, ILE440H, ILE448H, LEU386H, LEU389G, LEU389H, LEU397G, LEU409G, LEU409H, LEU410G, LEU410H, LEU417G, LEU417H, LEU453H, LYS134G, LYS143G, LYS154H, LYS155H, LYS201G, LYS33H, LYS400G, LYS420G, LYS420H, LYS446H, LYS488H, MET176G, MET411G, MET411H, MET457H, PHE122H, PHE383H, PHE399G, PHE399H, PHE421H, PHE436G, PHE436H, PHE490H, PHE500H, PRO121H, PRO160H, PRO202G, PRO429G, PRO429H, PRO432H, PRO88H, SER177G, SER185G, SER204G, SER393G, SER405G, SER405H, SER412G, SER416G, SER441G, SER444G, SER444H, SER451H, SER460H, THR137G, THR182G, THR186G, THR34H, THR379H, THR398G, THR398H, THR427G, THR427H, THR433H, THR456H, THR499H, THR501H, THR87H, TRP178G, TRP385H, TYR136G, TYR183H, TYR190G, TYR382H, TYR394G, TYR394H, TYR401G, TYR407G, TYR407H, TYR455H, TYR493H, VAL117H, VAL118H, VAL120H, VAL162H, VAL164H, VAL378H, VAL380H, VAL392G, VAL413G, VAL413H, VAL431H, VAL449H, VAL489H, VAL492H, VAL498H
• G-I: PHE500G, PHE500I, THR499G, THR499I, THR501G, THR501I, TYR190G, TYR190I, VAL498G, VAL498I
• G-J: ALA153G, ALA153J, ALA80G, ALA80J, ARG146G, ARG146J, ARG147G, ARG147J, ARG44G, ARG44J, ARG46G, ARG46J, ARG50G, ARG50J, ARG66G, ARG66J, ARG67G, ARG67J, ARG79G, ARG79J, ASN139J, ASN43G, ASN43J, ASN56G, ASN56J, ASP163G, ASP163J, ASP181J, ASP69G, ASP69J, CYS55G, CYS55J, CYS89G, CYS89J, GLN40G, GLN40J, GLN81G, GLN81J, GLN84G, GLN84J, GLU142J, GLU151G, GLU151J, GLU36G, GLU36J, GLU73G, GLU73J, GLU76G, GLU76J, GLY156G, GLY156J, GLY497G, GLY70G, GLY70J, GLY77G, GLY77J, HIS57G, HIS57J, ILE144J, ILE158G, ILE158J, ILE187G, ILE187J, ILE48G, ILE48J, ILE51G, ILE51J, ILE52G, ILE52J, ILE65G, ILE65J, ILE75G, ILE75J, LEU152G, LEU152J, LEU49G, LEU49J, LEU59G, LEU59J, LEU61G, LEU61J, LYS105G, LYS105J, LYS143G, LYS143J, LYS154G, LYS154J, LYS155G, LYS155J, LYS53G, LYS53J, MET150G, MET150J, PHE148J, PHE157G, PHE157J, PHE500G, PHE500J, PHE63G, PHE63J, PRO54G, PRO54J, PRO64G, PRO64J, SER185J, SER47G, SER47J, SER60G, SER60J, SER62G, SER62J, SER71G, SER71J, THR145J, THR149J, THR182G, THR182J, THR186G, THR186J, THR499G, THR499J, THR501G, THR501J, THR87G, THR87J, TRP72G, TRP72J, TYR183J, TYR493G, TYR493J, TYR78G, TYR78J, VAL101G, VAL101J, VAL162G, VAL162J, VAL45G, VAL45J, VAL498G, VAL498J, VAL58G, VAL58J, VAL74G, VAL74J
• G-K: ALA153G, ALA153K, ALA184G, ALA184K, ARG147G, ARG147K, ARG66G, ARG66K, ASN139G, ASN139K, ASP181G, ASP181K, GLU142G, GLU142K, GLU151G, GLU151K, GLY156G, GLY156K, GLY188G, GLY188K, HIS189G, HIS189K, ILE187G, ILE187K, LEU152K, LYS143G, LYS143K, LYS154G, LYS154K, LYS155G, LYS155K, MET150G, MET150K, PHE157K, SER185G, SER185K, THR182G, THR182K, THR186G, THR186K, TRP72G, TRP72K, TYR183G, TYR183K, TYR190G, TYR190K
• G-L: ALA153G, ALA180L, ALA184L, ALA194G, ALA194L, ALA196G, ALA434G, ALA443G, ALA443L, ALA454G, ALA496G, ARG146L, ARG147L, ARG174L, ARG35G, ARG396L, ARG403G, ARG403L, ARG419L, ARG439G, ARG44G, ARG459G, ARG491G, ARG86G, ASN139L, ASN193G, ASN193L, ASN387G, ASN388L, ASN390G, ASN390L, ASN406G, ASN406L, ASN494G, ASP119G, ASP138L, ASP163G, ASP181L, ASP191G, ASP191L, ASP404L, ASP438G, ASP447G, CYS115G, GLN205L, GLN414G, GLN414L, GLN437G, GLN463G, GLN81G, GLN84G, GLU140L, GLU142L, GLU173L, GLU175L, GLU224G, GLU36G, GLU384G, GLU402G, GLU402L, GLU415L, GLU418G, GLU418L, GLU435G, GLU445G, GLU445L, GLU458G, GLU495G, GLY156G, GLY159G, GLY161G, GLY206L, GLY207L, GLY395G, GLY395L, GLY426G, GLY442L, GLY452G, GLY497G, HIS189L, HIS195L, HIS209L, HIS221G, HIS391L, HIS408G, HIS408L, HIS450G, HIS57G, HIS85G, ILE144L, ILE192G, ILE192L, ILE203L, ILE208G, ILE428G, ILE430G, ILE430L, ILE440G, ILE448G, ILE65L, LEU141L, LEU296L, LEU386G, LEU389G, LEU389L, LEU397L, LEU409G, LEU409L, LEU410G, LEU410L, LEU417G, LEU417L, LEU453G, LYS134L, LYS143L, LYS154G, LYS155G, LYS201L, LYS33G, LYS400L, LYS420G, LYS420L, LYS446G, LYS488G, MET150L, MET176L, MET411G, MET411L, MET457G, PHE122G, PHE383G, PHE399G, PHE399L, PHE421G, PHE436G, PHE436L, PHE490G, PHE500G, PRO121G, PRO160G, PRO202L, PRO429G, PRO429L, PRO432G, PRO88G, SER177L, SER185L, SER204L, SER393L, SER405G, SER405L, SER412G, SER412L, SER416L, SER441L, SER444G, SER444L, SER451G, SER460G, THR137L, THR182L, THR186L, THR34G, THR379G, THR398G, THR398L, THR427G, THR427L, THR433G, THR456G, THR499G, THR501G, THR87G, TRP178L, TRP385G, TYR136L, TYR183G, TYR190L, TYR382G, TYR394G, TYR394L, TYR401L, TYR407G, TYR407L, TYR455G, TYR493G, VAL117G, VAL118G, VAL120G, VAL162G, VAL378G, VAL380G, VAL392L, VAL413G, VAL413L, VAL431G, VAL449G, VAL489G, VAL492G, VAL498G
• H-I: ALA153H, ALA153I, ALA184H, ALA184I, ARG147H, ARG147I, ARG66H, ARG66I, ASN139H, ASN139I, ASP181H, ASP181I, GLU142H, GLU142I, GLU151H, GLU151I, GLY156H, GLY156I, GLY188H, GLY188I, HIS189H, HIS189I, ILE187H, ILE187I, LEU152H, LYS143H, LYS143I, LYS154H, LYS154I, LYS155H, LYS155I, MET150H, MET150I, SER185H, SER185I, THR182H, THR182I, THR186H, THR186I, TRP72H, TRP72I, TYR183H, TYR183I, TYR190H, TYR190I
• H-J: PHE500H, PHE500J, TYR190H, TYR190J
• H-K: ALA153H, ALA153K, ALA80H, ALA80K, ARG146H, ARG147H, ARG147K, ARG44H, ARG44K, ARG46H, ARG46K, ARG50H, ARG50K, ARG66H, ARG66K, ARG79H, ARG79K, ASN139H, ASN43H, ASN43K, ASN494K, ASN56H, ASN56K, ASP163H, ASP163K, ASP181H, ASP69H, ASP69K, CYS55H, CYS55K, CYS89H, CYS89K, GLN40H, GLN40K, GLN81H, GLN81K, GLN84H, GLN84K, GLU142H, GLU151H, GLU151K, GLU36H, GLU36K, GLU73H, GLU73K, GLU76H, GLU76K, GLY156H, GLY156K, GLY497H, GLY497K, GLY70H, GLY70K, GLY77H, GLY77K, HIS57H, HIS57K, HIS82H, HIS82K, ILE144H, ILE158H, ILE158K, ILE187H, ILE187K, ILE48H, ILE48K, ILE51H, ILE51K, ILE52H, ILE52K, ILE65H, ILE65K, ILE75H, ILE75K, LEU152H, LEU152K, LEU49H, LEU49K, LEU59H, LEU59K, LEU61H, LEU61K, LYS105H, LYS105K, LYS143H, LYS143K, LYS154H, LYS154K, LYS155H, LYS155K, LYS53H, LYS53K, MET150H, MET150K, PHE148H, PHE157H, PHE157K, PHE500H, PHE500K, PHE63H, PHE63K, PRO54H, PRO54K, PRO64H, PRO64K, SER185H, SER47H, SER47K, SER60H, SER60K, SER62H, SER62K, SER71H, SER71K, THR145H, THR149H, THR182H, THR186H, THR499H, THR499K, THR501H, THR501K, THR87H, THR87K, TRP72H, TRP72K, TYR493H, TYR493K, TYR78H, TYR78K, VAL101H, VAL101K, VAL162H, VAL162K, VAL45H, VAL45K, VAL498H, VAL498K, VAL58H, VAL58K, VAL74H, VAL74K
• H-L: ALA153L, ALA180H, ALA184H, ALA194H, ALA194L, ALA196L, ALA434L, ALA443H, ALA443L, ALA454L, ALA496L, ARG146H, ARG147H, ARG174H, ARG35L, ARG396H, ARG403H, ARG403L, ARG419H, ARG439L, ARG459L, ARG491L, ARG86L, ASN139H, ASN193H, ASN193L, ASN387L, ASN388H, ASN390H, ASN390L, ASN406H, ASN406L, ASN494L, ASP119L, ASP138H, ASP163L, ASP181H, ASP191H, ASP191L, ASP404H, ASP438L, ASP447L, CYS115L, GLN205H, GLN414H, GLN414L, GLN437L, GLN463L, GLN81L, GLN84L, GLU142H, GLU173H, GLU224L, GLU384L, GLU402H, GLU402L, GLU415H, GLU418H, GLU435L, GLU445H, GLU445L, GLU458L, GLU495L, GLY156L, GLY159L, GLY161L, GLY206H, GLY207H, GLY395H, GLY395L, GLY426L, GLY442L, GLY452L, GLY497L, HIS189H, HIS195H, HIS209H, HIS221L, HIS391H, HIS408H, HIS408L, HIS450L, HIS57L, HIS85L, ILE192H, ILE192L, ILE203H, ILE208L, ILE428L, ILE430H, ILE430L, ILE440L, ILE448L, LEU386L, LEU389H, LEU389L, LEU397H, LEU409H, LEU409L, LEU410H, LEU410L, LEU417H, LEU417L, LEU453L, LYS134H, LYS143H, LYS154H, LYS154L, LYS155L, LYS201H, LYS33L, LYS400H, LYS420H, LYS420L, LYS446L, LYS488L, MET150H, MET176H, MET411H, MET411L, MET457L, PHE122L, PHE383L, PHE399H, PHE399L, PHE421L, PHE436H, PHE436L, PHE490L, PHE500L, PRO121L, PRO160L, PRO202H, PRO429H, PRO429L, PRO432L, PRO88L, SER177H, SER185H, SER204H, SER393H, SER405H, SER405L, SER412H, SER416H, SER441H, SER441L, SER444H, SER444L, SER451L, SER460L, THR137H, THR182H, THR186H, THR34L, THR379L, THR398H, THR398L, THR427H, THR427L, THR433L, THR456L, THR499L, THR501L, THR87L, TRP178H, TRP385L, TYR136H, TYR183L, TYR190H, TYR382L, TYR394H, TYR394L, TYR401H, TYR407H, TYR407L, TYR455L, TYR493L, VAL117L, VAL118L, VAL120L, VAL162L, VAL164L, VAL380L, VAL392H, VAL413H, VAL413L, VAL431L, VAL449L, VAL489L, VAL492L, VAL498L
• I-J: ALA153I, ALA180J, ALA184J, ALA194I, ALA194J, ALA196I, ALA434I, ALA443I, ALA443J, ALA454I, ALA496I, ARG146J, ARG147J, ARG174J, ARG35I, ARG396J, ARG403I, ARG403J, ARG419J, ARG439I, ARG459I, ARG491I, ARG86I, ASN139J, ASN193I, ASN193J, ASN387I, ASN388J, ASN390I, ASN390J, ASN406I, ASN406J, ASN494I, ASP119I, ASP138J, ASP163I, ASP181J, ASP191I, ASP191J, ASP404J, ASP438I, ASP447I, CYS115I, GLN205J, GLN414I, GLN414J, GLN437I, GLN463I, GLN81I, GLN84I, GLU142J, GLU173J, GLU224I, GLU384I, GLU402I, GLU402J, GLU415J, GLU418J, GLU435I, GLU445I, GLU445J, GLU458I, GLU495I, GLY156I, GLY159I, GLY161I, GLY206J, GLY207J, GLY395I, GLY395J, GLY426I, GLY442I, GLY452I, GLY497I, HIS189J, HIS195J, HIS209J, HIS221I, HIS391J, HIS408I, HIS408J, HIS450I, HIS57I, HIS85I, ILE179J, ILE192I, ILE192J, ILE203J, ILE208I, ILE428I, ILE430I, ILE430J, ILE440I, ILE448I, LEU386I, LEU389I, LEU389J, LEU397J, LEU409I, LEU409J, LEU410I, LEU410J, LEU417I, LEU417J, LEU453I, LYS134J, LYS143J, LYS154I, LYS154J, LYS155I, LYS201J, LYS33I, LYS400J, LYS420I, LYS420J, LYS446I, LYS488I, MET150J, MET176J, MET411I, MET411J, MET457I, PHE122I, PHE383I, PHE399I, PHE399J, PHE421I, PHE436I, PHE436J, PHE490I, PHE500I, PRO121I, PRO160I, PRO202J, PRO429I, PRO429J, PRO432I, PRO88I, SER177J, SER185J, SER204J, SER393J, SER405I, SER405J, SER412J, SER416J, SER441J, SER444I, SER444J, SER451I, SER460I, THR137J, THR182J, THR186J, THR34I, THR379I, THR398I, THR398J, THR427I, THR427J, THR433I, THR456I, THR499I, THR501I, THR87I, TRP178J, TRP385I, TYR136J, TYR183I, TYR190J, TYR382I, TYR394I, TYR401J, TYR407I, TYR407J, TYR455I, TYR493I, VAL117I, VAL118I, VAL120I, VAL162I, VAL164I, VAL380I, VAL392J, VAL413I, VAL413J, VAL431I, VAL449I, VAL489I, VAL492I, VAL498I
• I-K: ALA153K, ALA180I, ALA184I, ALA194I, ALA194K, ALA196K, ALA434K, ALA443I, ALA443K, ALA454K, ALA496K, ARG146I, ARG147I, ARG174I, ARG35K, ARG396I, ARG403I, ARG403K, ARG419I, ARG439K, ARG44K, ARG459K, ARG491K, ARG66I, ARG86K, ASN139I, ASN193I, ASN193K, ASN387K, ASN388I, ASN390I, ASN390K, ASN406I, ASN406K, ASN494K, ASP119K, ASP138I, ASP163K, ASP181I, ASP191I, ASP191K, ASP404I, ASP438K, ASP447K, CYS115K, GLN205I, GLN414I, GLN414K, GLN437K, GLN463K, GLN81K, GLN84K, GLU142I, GLU173I, GLU224K, GLU36K, GLU384K, GLU402I, GLU402K, GLU415I, GLU418I, GLU418K, GLU435K, GLU445I, GLU445K, GLU458K, GLU495K, GLY156K, GLY159K, GLY161K, GLY206I, GLY207I, GLY395I, GLY395K, GLY426K, GLY442I, GLY442K, GLY452K, GLY497K, HIS189I, HIS195I, HIS209I, HIS221K, HIS391I, HIS408I, HIS408K, HIS450K, HIS57K, HIS85K, ILE179I, ILE192I, ILE192K, ILE203I, ILE208K, ILE428K, ILE430I, ILE430K, ILE440K, ILE448K, ILE65I, LEU141I, LEU296I, LEU386K, LEU389I, LEU389K, LEU397I, LEU409I, LEU409K, LEU410I, LEU410K, LEU417I, LEU417K, LEU453K, LYS134I, LYS143I, LYS154K, LYS155K, LYS201I, LYS33K, LYS400I, LYS420I, LYS420K, LYS446K, LYS488K, MET150I, MET176I, MET411I, MET411K, MET457K, PHE122K, PHE383K, PHE399I, PHE399K, PHE421K, PHE436I, PHE436K, PHE490K, PHE500K, PRO121K, PRO160K, PRO202I, PRO429I, PRO429K, PRO432K, PRO88K, SER177I, SER185I, SER204I, SER393I, SER405I, SER405K, SER412I, SER416I, SER441I, SER444I, SER444K, SER451K, SER460K, THR137I, THR182I, THR186I, THR34K, THR379K, THR398I, THR398K, THR427I, THR427K, THR433K, THR456K, THR499K, THR501K, THR87K, TRP178I, TRP385K, TYR136I, TYR183K, TYR190I, TYR382K, TYR394I, TYR394K, TYR401I, TYR407I, TYR407K, TYR455K, TYR493K, VAL117K, VAL118K, VAL120K, VAL162K, VAL378K, VAL380K, VAL392I, VAL413I, VAL413K, VAL431K, VAL449K, VAL489K, VAL492K, VAL498K
• I-L: ALA153I, ALA153L, ALA80I, ALA80L, ARG146I, ARG146L, ARG147I, ARG147L, ARG44I, ARG44L, ARG46I, ARG46L, ARG50I, ARG50L, ARG66I, ARG66L, ARG67L, ARG79I, ARG79L, ASN139I, ASN43I, ASN43L, ASN494L, ASN56I, ASN56L, ASP163I, ASP163L, ASP181I, ASP181L, ASP69I, ASP69L, CYS55I, CYS55L, CYS89I, CYS89L, GLN40I, GLN40L, GLN81I, GLN81L, GLN84I, GLN84L, GLU142I, GLU142L, GLU151I, GLU151L, GLU36I, GLU36L, GLU73I, GLU73L, GLU76I, GLU76L, GLY156I, GLY156L, GLY497I, GLY497L, GLY70I, GLY70L, GLY77I, GLY77L, HIS57I, HIS57L, ILE144I, ILE158I, ILE158L, ILE187L, ILE48I, ILE48L, ILE51I, ILE51L, ILE52I, ILE52L, ILE65I, ILE65L, ILE75I, ILE75L, LEU152I, LEU152L, LEU49I, LEU49L, LEU59I, LEU59L, LEU61I, LEU61L, LYS105I, LYS105L, LYS143I, LYS143L, LYS154I, LYS154L, LYS155I, LYS155L, LYS53I, LYS53L, MET150I, MET150L, PHE148I, PHE157I, PHE157L, PHE500I, PHE500L, PHE63I, PHE63L, PRO54I, PRO54L, PRO64I, PRO64L, SER185I, SER185L, SER47I, SER47L, SER60I, SER60L, SER62I, SER62L, SER71I, SER71L, THR145I, THR149I, THR149L, THR182I, THR182L, THR186I, THR186L, THR499I, THR499L, THR501I, THR501L, TRP178I, TRP178L, TRP72I, TRP72L, TYR183I, TYR183L, TYR493I, TYR493L, TYR78I, TYR78L, VAL101I, VAL101L, VAL162I, VAL162L, VAL45I, VAL45L, VAL498I, VAL498L, VAL58I, VAL58L, VAL74I, VAL74L
• J-K: ALA153J, ALA180K, ALA184K, ALA194J, ALA194K, ALA196J, ALA434J, ALA443J, ALA443K, ALA454J, ALA496J, ARG146K, ARG174K, ARG217J, ARG35J, ARG396K, ARG403J, ARG403K, ARG419K, ARG439J, ARG44J, ARG459J, ARG491J, ARG86J, ASN139K, ASN193J, ASN193K, ASN225J, ASN387J, ASN388K, ASN390J, ASN390K, ASN406J, ASN406K, ASN494J, ASP119J, ASP138K, ASP163J, ASP181K, ASP191J, ASP191K, ASP404K, ASP438J, ASP447J, CYS115J, GLN205K, GLN414J, GLN414K, GLN437J, GLN463J, GLN81J, GLN84J, GLU142K, GLU173K, GLU224J, GLU384J, GLU402J, GLU402K, GLU415K, GLU418K, GLU435J, GLU445J, GLU445K, GLU458J, GLU495J, GLY156J, GLY159J, GLY161J, GLY206K, GLY207K, GLY395J, GLY395K, GLY426J, GLY442K, GLY452J, GLY497J, HIS189K, HIS195K, HIS209K, HIS221J, HIS391K, HIS408J, HIS408K, HIS450J, HIS57J, HIS85J, ILE192J, ILE192K, ILE203K, ILE208J, ILE428J, ILE430J, ILE430K, ILE440J, ILE448J, LEU141K, LEU386J, LEU389J, LEU389K, LEU397K, LEU409J, LEU409K, LEU410J, LEU410K, LEU417J, LEU417K, LEU453J, LYS134K, LYS143K, LYS154J, LYS155J, LYS201K, LYS33J, LYS400K, LYS420J, LYS420K, LYS446J, LYS488J, MET176K, MET411J, MET411K, MET457J, PHE122J, PHE383J, PHE399J, PHE399K, PHE421J, PHE436J, PHE436K, PHE490J, PHE500J, PRO121J, PRO160J, PRO202K, PRO429J, PRO429K, PRO432J, PRO88J, SER177K, SER185K, SER204K, SER393K, SER405J, SER405K, SER412K, SER416K, SER441J, SER441K, SER444J, SER444K, SER451J, SER460J, THR137K, THR182K, THR186K, THR34J, THR379J, THR398J, THR398K, THR427J, THR427K, THR433J, THR456J, THR499J, THR501J, THR87J, TRP178K, TRP385J, TYR136K, TYR183J, TYR183K, TYR190K, TYR382J, TYR394J, TYR394K, TYR401K, TYR407J, TYR407K, TYR455J, TYR493J, VAL117J, VAL118J, VAL120J, VAL162J, VAL164J, VAL378J, VAL380J, VAL392K, VAL413J, VAL413K, VAL431J, VAL449J, VAL489J, VAL492J, VAL498J
• J-L: ALA153J, ALA153L, ALA184J, ALA184L, ARG147J, ARG147L, ARG66J, ARG66L, ASN139J, ASN139L, ASP181J, ASP181L, GLU142J, GLU142L, GLU151J, GLU151L, GLY156J, GLY156L, GLY188J, GLY188L, HIS189J, HIS189L, ILE187J, ILE187L, LEU152J, LEU152L, LYS143J, LYS143L, LYS154J, LYS154L, LYS155J, LYS155L, MET150J, MET150L, PHE157J, PHE157L, SER185J, SER185L, THR182J, THR182L, THR186J, THR186L, TRP72J, TRP72L, TYR183J, TYR190J, TYR190L
• K-L: PHE500K, PHE500L, THR499K, THR499L, THR501K, THR501L, TYR190K, TYR190L, VAL498K