3QE0

a galpha-i1 p-loop mutation prevents transition to the activated state

• Total interactions analyzed: 10
• Total true interactions: 5
• Strongest Interaction:
  • Chains: B-G
  • Int. Res.: 52
  • Norm. En. per Res.: -5.2595
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-28.7801	20.7041	-115.973	-124.049	62	11	1	5682	0	23	28
A-C	0.0	11.0803	-42.5612	-31.4809	40	1	2	2147	0	11	6
A-F	0.0	0.0	-122.268	-122.268	47	11	1	4617	0	4	4
B-C	0.0	5.5514	-1.1728	4.3786	5	0	0	98	0	4	4
B-G	-21.1604	-34.3703	-217.963	-273.4937	52	14	1	7891	2	8	9

Interface residues

• A-B: ALA32A, ALA338A, ALA59B, ALA71B, ARG178B, ASN346A, ASN347A, ASP193A, ASP200B, ASP337A, ASP341A, ASP350A, CYS351A, CYS66B, GLN52B, GLN68B, GLU186B, GLU58B, GLU63B, GLU64B, GLU65B, GLY352A, GLY60B, HIS188B, ILE184B, ILE343A, ILE344A, ILE55B, LEU175B, LEU194A, LEU348A, LEU353A, LYS180B, LYS192A, LYS345A, LYS349A, LYS51B, LYS54B, LYS67B, LYS70B, MET198B, MET53B, PHE191A, PHE354A, SER47B, SER62B, THR177B, THR181B, THR182B, THR187B, THR340A, THR48B, TYR61B, TYR69B, VAL174B, VAL179B, VAL185B, VAL339A, VAL342A, VAL50B, VAL72B, VAL73B
• A-C: ALA121C, ALA124C, ALA59A, ARG129C, ASN166C, ASP193A, ASP337A, GLN106C, GLN164C, GLN333A, GLU122C, GLU58A, GLY112C, GLY117C, GLY125C, GLY60A, HIS188A, HIS195A, HIS57A, ILE56A, LEU110C, LEU123C, LEU194A, LYS128C, LYS192A, LYS330A, LYS54A, LYS67C, LYS70C, MET119C, PHE118C, PHE189A, PHE191A, PHE196A, PHE334A, PRO165C, THR120C, THR190A, TYR167C, VAL126C
• A-F: ALA41A, ARG208A, ARG42A, ASN255A, ASN256A, ASP251A, ASP7F, CYS214A, CYS224A, CYS254A, GLU207A, GLU245A, GLY183A, GLY202A, GLY40A, HIS213A, ILE184A, ILE212A, ILE221A, ILE253A, LEU249A, LEU37A, LEU38A, LEU39A, LEU9F, LYS209A, LYS210A, LYS248A, LYS257A, LYS46A, MET240A, MET247A, PHE215A, PHE223A, PHE250A, PHE259A, PHE8F, SER206A, SER246A, SER252A, SER44A, THR4F, TRP211A, TRP258A, TRP5F, TYR6F, VAL201A
• B-C: ASP160C, GLN164C, GLU63B, GLU64B, PRO165C
• B-G: ALA41B, ARG205B, ARG208B, ARG2G, ASN255B, ASN256B, ASP251B, ASP7G, CYS214B, CYS254B, GLN204B, GLU11G, GLU207B, GLU245B, GLY183B, GLY202B, GLY203B, GLY40B, HIS213B, ILE184B, ILE212B, ILE221B, ILE253B, LEU249B, LEU37B, LEU38B, LEU39B, LEU9G, LYS209B, LYS210B, LYS248B, LYS257B, LYS46B, MET10G, MET247B, PHE215B, PHE223B, PHE250B, PHE259B, PHE8G, SER1G, SER206B, SER246B, SER252B, THR182B, THR4G, TRP211B, TRP258B, TRP5G, TYR6G, VAL201B, VAL3G