3QA3

crystal structure of a-domain in complex with antibody

• Total interactions analyzed: 66
• Total true interactions: 25
• Strongest Interaction:
  • Chains: K-L
  • Int. Res.: 60
  • Norm. En. per Res.: -3.2566
• Hub Node: B(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
C-D	-24.1153	-5.7293	167.096	137.2513	202	29	10	21163	2	19	16
C-G	-9.2847	0.0	-106.464	-115.7487	46	5	2	3732	0	3	2
C-I	0.0	-8.3012	-19.3289	-27.6301	29	1	0	1092	1	9	7
D-G	-40.7419	-1.683	-149.444	-191.8689	59	6	0	5058	8	20	27
D-B	-30.691	-3.8596	-62.4199	-96.9705	38	5	0	2266	1	4	3
D-I	0.0	1.448	-51.2366	-49.7886	32	5	0	2174	0	11	5
D-K	0.0	0.0	-0.0713	-0.0713	4	0	0	27	0	0	0
G-A	0.0	0.0	-0.051	-0.051	8	0	0	31	0	2	3
G-F	-12.9226	-16.1017	-36.5494	-65.5737	34	6	0	1761	2	8	6
G-H	-2.2056	1.9771	-77.9091	-78.1375	36	5	0	3234	0	15	6
G-I	0.0	0.0	-5.2016	-5.2016	16	0	1	644	0	2	3
A-B	-17.7328	-5.1678	144.747	121.8464	206	19	11	21278	1	19	16
A-E	-10.4034	0.0	-114.321	-124.7244	48	5	2	3736	0	3	2
A-K	0.0	0.0	-23.6837	-23.6837	24	1	0	1167	0	5	1
B-E	-29.417	5.7173	-149.324	-173.0237	57	7	0	4964	9	20	27
B-H	0.0	0.0	-0.0481	-0.0481	5	0	0	19	0	0	0
B-J	0.0	0.0	-24.9821	-24.9821	27	2	0	1330	0	6	1
B-K	-46.7687	-0.0757	-98.081	-144.9254	59	4	1	4186	0	11	14
F-H	-44.8593	-19.5294	118.359	53.9703	208	22	10	21612	1	20	15
F-I	-19.3778	0.0	-105.019	-124.3968	47	3	2	3567	0	3	2
H-I	-38.5387	-1.4094	-153.365	-193.3131	60	7	0	5211	9	20	27
H-K	-18.9411	-4.8873	-44.103	-67.9314	31	4	0	1837	1	3	3
J-K	-40.5561	-18.6506	177.25	118.0432	203	14	11	20795	2	18	15
J-L	-21.6853	0.0	-108.476	-130.1613	45	3	2	3661	0	3	2
K-L	-43.9258	1.3002	-152.769	-195.3946	60	8	0	5199	9	21	27

Interface residues

• C-D: ALA106C, ALA110D, ALA136C, ALA136D, ALA140D, ALA141D, ALA179D, ALA40C, ALA57C, ALA99D, ARG199D, ARG217C, ARG224D, ARG52D, ARG60C, ASN143C, ASN144C, ASN144D, ASN163C, ASN167C, ASN216C, ASN218C, ASN34C, ASP107D, ASP112D, ASP171C, ASP173C, ASP176C, ASP1C, ASP225D, ASP63D, CYS140C, CYS151D, CYS220C, CYS226D, CYS94C, CYS98D, GLN116D, GLN130C, GLN142D, GLN182D, GLN37D, GLN41D, GLN43C, GLN44C, GLN45D, GLN48C, GLN8D, GLN95C, GLN96C, GLU101D, GLU129C, GLU219C, GLU44D, GLU48D, GLU61C, GLY102D, GLY105C, GLY105D, GLY107C, GLY108D, GLY115D, GLY117D, GLY134C, GLY135C, GLY138D, GLY150D, GLY164C, GLY173D, GLY46D, GLY47C, GLY51D, HIS103D, HIS175D, ILE123C, ILE221D, ILE50D, ILE53D, ILE54C, LEU102C, LEU131C, LEU135D, LEU142C, LEU149D, LEU152D, LEU166C, LEU181D, LEU185C, LEU185D, LEU187C, LEU188D, LEU39C, LEU47D, LEU52C, LEU53C, LYS109C, LYS154D, LYS175C, LYS213C, LYS219D, LYS220D, LYS36C, LYS40D, LYS45C, LYS51C, LYS61D, LYS65D, MET111D, MET146D, MET181C, PHE104C, PHE124C, PHE141C, PHE145C, PHE177D, PHE215C, PHE66D, PRO101C, PRO125C, PRO126C, PRO134D, PRO137D, PRO178D, PRO43D, PRO50C, PRO64D, SER100D, SER122C, SER127C, SER128C, SER131D, SER133C, SER137C, SER139D, SER168C, SER171D, SER172D, SER180C, SER182C, SER183C, SER183D, SER189D, SER190D, SER191D, SER214C, SER33C, SER49C, SER62C, SER99C, THR103C, THR120C, THR132C, THR148D, THR170C, THR176D, THR178C, THR184C, THR186C, THR187D, THR193D, THR59C, TRP114D, TRP165D, TRP169C, TRP38D, TRP41C, TRP49D, TRP56C, TYR100C, TYR104D, TYR106D, TYR109D, TYR113D, TYR133D, TYR179C, TYR186D, TYR192C, TYR31C, TYR35D, TYR38C, TYR42C, TYR55C, TYR62D, TYR92C, TYR93C, TYR97C, TYR97D, TYR98C, VAL121C, VAL132D, VAL138C, VAL139C, VAL147D, VAL153D, VAL165C, VAL174D, VAL180D, VAL192D, VAL222D, VAL39D, VAL91C, VAL95D
• C-G: ALA274G, ARG208G, ARG276G, ASN28C, ASN34C, ASP140G, ASP242G, ASP248G, ASP273G, GLN27C, GLN35C, GLN95C, GLN96C, GLU178G, GLU179G, GLU244G, GLU283G, GLY207G, GLY243G, GLY247G, HIS210G, ILE2C, LEU102C, LEU29C, LEU30C, LYS245G, LYS279G, PHE246G, PHE275G, PRO101C, PRO249G, SER142G, SER144G, SER277G, SER280G, SER32C, SER33C, SER99C, THR209G, THR241G, TRP56C, TYR100C, TYR31C, TYR38C, TYR97C, TYR98C
• C-I: ARG151I, ARG152I, ARG196I, ARG60C, ASN301I, ASN310I, ASP66C, GLN163I, GLN309I, GLU155I, GLU303I, GLU314I, GLU61C, GLY63C, ILE54C, LEU52C, LEU53C, LYS306I, LYS36C, PHE156I, PRO65C, SER158I, SER62C, THR159I, THR307I, THR59C, TRP56C, TYR55C, VAL64C
• D-G: ALA110D, ALA56D, ARG181G, ARG208G, ARG52D, ASN57D, ASP107D, ASP140G, ASP242G, ASP33D, ASP54D, ASP58D, GLN175G, GLN204G, GLN37D, GLU101D, GLU178G, GLU179G, GLU221G, GLU244G, GLY102D, GLY105D, GLY108D, GLY141G, GLY143G, GLY207G, GLY243G, HIS103D, HIS210G, ILE145G, ILE146G, ILE182G, ILE34D, ILE53D, LEU205G, LEU206G, LYS217G, LYS245G, LYS32D, LYS59D, LYS61D, MET111D, PHE180G, PHE246G, PRO147G, PRO249G, SER142G, SER144G, SER177G, THR203G, THR209G, THR213G, THR60D, TRP49D, TYR104D, TYR106D, TYR109D, TYR176G, TYR35D
• D-B: ALA56D, ALA74D, ALA81D, ARG199B, ASN166B, ASN207B, ASN57D, ASN79D, ASP58D, ASP75D, GLN84D, GLU202B, ILE72D, LEU170B, LYS21D, LYS220B, LYS32D, PRO195B, PRO198B, PRO200B, PRO55D, SER167B, SER169B, SER196B, SER197B, SER19D, SER201B, SER23D, SER77D, SER78D, THR203B, THR205B, THR71D, THR73D, THR76D, THR80D, TYR82D, VAL204B
• D-I: ARG151I, ARG152I, ARG196I, ASN192I, ASN194I, ASN301I, ASN30D, ASP112D, ASP149I, ASP33D, GLN3D, GLU155I, GLU162I, GLU303I, GLY102D, GLY105D, GLY28D, HIS103D, HIS148I, ILE146I, LEU198I, LYS200I, LYS306I, PHE29D, PRO195I, SER197I, SER27D, TYR104D, TYR106D, TYR109D, TYR113D, VAL4D
• D-K: LYS216D, LYS216K, SER77D, SER77K
• G-A: ALA86A, ASN191G, GLN190G, GLU87A, LYS175A, LYS187G, LYS85A, SER174A
• G-F: ALA304G, ARG151G, ARG152G, ARG196G, ARG313G, ARG60F, ASN301G, ASN310G, ASP66F, GLN163G, GLN309G, GLN311G, GLU155G, GLU162G, GLU303G, GLU61F, GLY63F, ILE54F, LEU52F, LEU53F, LYS306G, LYS36F, LYS51F, PHE156G, PRO65F, SER158G, SER62F, THR159G, THR307G, THR59F, TRP56F, TYR55F, VAL160G, VAL64F
• G-H: ARG151G, ARG152G, ARG196G, ASN194G, ASN301G, ASN30H, ASN79H, ASP112H, ASP149G, ASP33H, GLN3H, GLU155G, GLU303G, GLY102H, GLY105H, GLY28H, HIS103H, HIS148G, ILE146G, LEU198G, LYS200G, LYS306G, PHE29H, PRO147G, PRO195G, PRO201G, PRO26H, SER158G, SER197G, SER27H, TYR104H, TYR106H, TYR109H, TYR113H, VAL199G, VAL4H
• G-I: GLN204G, GLN204I, GLY143G, GLY143I, HIS148G, HIS148I, ILE145G, ILE145I, ILE146G, ILE146I, LEU206G, LEU206I, PRO147G, PRO147I, SER144G, SER144I
• A-B: ALA106A, ALA110B, ALA136A, ALA136B, ALA140B, ALA141B, ALA179B, ALA40A, ALA57A, ALA99B, ARG199B, ARG217A, ARG224B, ARG42B, ARG52B, ARG60A, ASN143A, ASN144A, ASN144B, ASN167A, ASN216A, ASN218A, ASN34A, ASP107B, ASP112B, ASP171A, ASP173A, ASP176A, ASP1A, ASP225B, ASP63B, CYS140A, CYS151B, CYS220A, CYS226B, CYS94A, CYS98B, GLN116B, GLN130A, GLN142B, GLN182B, GLN37B, GLN41B, GLN43A, GLN44A, GLN45B, GLN48A, GLN5B, GLN8B, GLN95A, GLN96A, GLU101B, GLU129A, GLU219A, GLU3A, GLU44B, GLU48B, GLU61A, GLY102B, GLY105A, GLY105B, GLY107A, GLY108B, GLY115B, GLY117B, GLY134A, GLY135A, GLY138B, GLY150B, GLY164A, GLY173B, GLY46B, GLY47A, GLY51B, HIS103B, HIS175B, ILE123A, ILE221B, ILE50B, ILE53B, ILE54A, LEU102A, LEU131A, LEU135B, LEU142A, LEU149B, LEU152B, LEU166A, LEU181B, LEU185A, LEU185B, LEU187A, LEU188B, LEU39A, LEU47B, LEU52A, LEU53A, LYS109A, LYS148A, LYS154B, LYS175A, LYS213A, LYS219B, LYS220B, LYS36A, LYS40B, LYS45A, LYS51A, LYS61B, LYS65B, MET111B, MET146B, MET181A, PHE104A, PHE124A, PHE141A, PHE145A, PHE177B, PHE215A, PHE66B, PRO101A, PRO125A, PRO126A, PRO134B, PRO137B, PRO178B, PRO43B, PRO50A, PRO64B, SER100B, SER122A, SER127A, SER128A, SER131B, SER133A, SER137A, SER139B, SER168A, SER171B, SER172B, SER180A, SER182A, SER183A, SER183B, SER189B, SER190B, SER191B, SER214A, SER33A, SER49A, SER62A, SER99A, SER9A, THR103A, THR120A, THR132A, THR148B, THR170A, THR176B, THR178A, THR184A, THR186A, THR187B, THR193B, THR59A, TRP114B, TRP165B, TRP169A, TRP38B, TRP41A, TRP49B, TRP56A, TYR100A, TYR104B, TYR106B, TYR109B, TYR113B, TYR133B, TYR179A, TYR186B, TYR192A, TYR31A, TYR35B, TYR38A, TYR42A, TYR55A, TYR62B, TYR92A, TYR93A, TYR97A, TYR97B, TYR98A, VAL121A, VAL132B, VAL138A, VAL139A, VAL147B, VAL153B, VAL165A, VAL174B, VAL180B, VAL192B, VAL222B, VAL39B, VAL91A, VAL95B
• A-E: ALA274E, ARG208E, ARG276E, ASN28A, ASN34A, ASP140E, ASP242E, ASP248E, ASP273E, GLN27A, GLN35A, GLN95A, GLN96A, GLU178E, GLU179E, GLU244E, GLU283E, GLY207E, GLY243E, GLY247E, HIS210E, ILE2A, LEU102A, LEU29A, LEU30A, LYS245E, LYS279E, LYS36A, PHE246E, PHE275E, PRO101A, PRO249E, SER142E, SER144E, SER277E, SER280E, SER32A, SER33A, SER99A, THR209E, THR211E, THR241E, TRP56A, TYR100A, TYR31A, TYR38A, TYR97A, TYR98A
• A-K: ALA125K, ALA212K, GLN130A, GLU129A, GLU193A, GLY155K, HIS210K, LEU131A, LEU185K, LYS126K, LYS189A, PHE157K, PRO129K, PRO130K, SER127A, SER128A, SER133A, SER213K, SER214K, THR127K, THR128K, THR132A, THR215K, TYR156K
• B-E: ALA110B, ALA56B, ARG181E, ARG208E, ARG52B, ASN57B, ASP107B, ASP140E, ASP242E, ASP33B, ASP54B, ASP58B, GLN175E, GLN204E, GLN37B, GLU101B, GLU178E, GLU179E, GLU244E, GLY102B, GLY105B, GLY108B, GLY141E, GLY143E, GLY207E, GLY243E, HIS103B, HIS210E, ILE145E, ILE146E, ILE182E, ILE34B, ILE53B, LEU205E, LEU206E, LYS217E, LYS245E, LYS32B, LYS59B, LYS61B, MET111B, PHE180E, PHE246E, PRO147E, PRO249E, SER142E, SER144E, SER177E, THR203E, THR209E, THR213E, THR60B, TRP49B, TYR104B, TYR106B, TYR109B, TYR35B
• B-H: LYS216B, LYS216H, SER77B, SER77H, SER78H
• B-J: ALA125B, ALA212B, CYS220J, GLN130J, GLU129J, GLU193J, GLY155B, HIS210B, LEU131J, LEU185B, LYS126B, LYS15B, LYS189J, PHE157B, PRO129B, PRO130B, SER127J, SER128J, SER131B, SER133J, SER213B, SER214B, THR127B, THR128B, THR132J, THR215B, TYR156B
• B-K: ALA209B, ALA209K, ALA212B, ALA212K, ASN207B, ASN207K, ASP218B, ASP218K, ASP225B, CYS206B, CYS226B, CYS226K, HIS210B, HIS210K, ILE221B, ILE221K, LYS126B, LYS126K, LYS216B, LYS216K, LYS219B, LYS219K, LYS220B, LYS220K, PRO129B, PRO129K, PRO130B, PRO130K, PRO134B, PRO134K, PRO211B, PRO211K, PRO223K, SER131B, SER131K, SER213B, SER213K, SER214B, SER214K, THR127B, THR127K, THR128B, THR128K, THR203B, THR203K, THR205B, THR205K, THR215B, THR215K, TYR133B, TYR133K, VAL132B, VAL132K, VAL208B, VAL208K, VAL217B, VAL217K, VAL222B, VAL222K
• F-H: ALA106F, ALA110H, ALA136F, ALA136H, ALA140H, ALA141H, ALA179H, ALA40F, ALA57F, ALA99H, ARG199H, ARG217F, ARG224H, ARG42H, ARG52H, ASN143F, ASN144F, ASN144H, ASN167F, ASN216F, ASN218F, ASN34F, ASP107H, ASP112H, ASP171F, ASP173F, ASP176F, ASP1F, ASP225H, ASP54H, ASP63H, CYS140F, CYS151H, CYS220F, CYS226H, CYS94F, CYS98H, GLN116H, GLN130F, GLN142H, GLN182H, GLN37H, GLN41H, GLN43F, GLN44F, GLN45H, GLN48F, GLN8H, GLN95F, GLN96F, GLU101H, GLU129F, GLU219F, GLU3F, GLU44H, GLU48H, GLU61F, GLY102H, GLY105F, GLY105H, GLY107F, GLY108H, GLY115H, GLY117H, GLY134F, GLY135F, GLY138H, GLY150H, GLY164F, GLY173H, GLY46H, GLY47F, GLY51H, HIS103H, HIS175H, ILE123F, ILE221H, ILE50H, ILE53H, ILE54F, LEU102F, LEU131F, LEU135H, LEU142F, LEU149H, LEU152H, LEU166F, LEU181H, LEU185F, LEU185H, LEU187F, LEU188H, LEU39F, LEU47H, LEU52F, LEU53F, LEU6H, LYS109F, LYS148F, LYS154H, LYS175F, LYS213F, LYS219H, LYS220H, LYS36F, LYS40H, LYS51F, LYS61H, LYS65H, MET111H, MET146H, MET181F, PHE104F, PHE124F, PHE141F, PHE145F, PHE177H, PHE215F, PHE66H, PRO101F, PRO125F, PRO126F, PRO134H, PRO137H, PRO178H, PRO43H, PRO50F, PRO64H, SER100H, SER122F, SER127F, SER128F, SER131H, SER133F, SER137F, SER139H, SER168F, SER171H, SER172H, SER180F, SER182F, SER183F, SER183H, SER189H, SER190H, SER191H, SER214F, SER33F, SER49F, SER62F, SER99F, SER9F, THR103F, THR108F, THR120F, THR132F, THR143H, THR148H, THR170F, THR176H, THR178F, THR184F, THR186F, THR187H, THR193H, THR59F, THR60H, TRP114H, TRP165H, TRP169F, TRP38H, TRP41F, TRP49H, TRP56F, TYR100F, TYR104H, TYR106H, TYR109H, TYR113H, TYR133H, TYR179F, TYR192F, TYR31F, TYR35H, TYR38F, TYR42F, TYR55F, TYR62H, TYR92F, TYR93F, TYR97F, TYR97H, TYR98F, VAL121F, VAL132H, VAL138F, VAL139F, VAL147H, VAL153H, VAL165F, VAL174H, VAL180H, VAL192H, VAL212F, VAL222H, VAL39H, VAL91F, VAL95H
• F-I: ALA274I, ARG208I, ARG276I, ASN28F, ASN34F, ASP140I, ASP242I, ASP248I, ASP273I, GLN27F, GLN35F, GLN95F, GLN96F, GLU178I, GLU179I, GLU244I, GLU283I, GLY207I, GLY243I, GLY247I, HIS210I, ILE2F, LEU102F, LEU29F, LEU30F, LYS245I, LYS279I, PHE246I, PHE275I, PRO101F, PRO249I, SER142I, SER144I, SER277I, SER280I, SER32F, SER33F, SER99F, THR209I, THR211I, THR241I, TRP56F, TYR100F, TYR31F, TYR38F, TYR97F, TYR98F
• H-I: ALA110H, ALA56H, ARG181I, ARG208I, ARG52H, ASN57H, ASP107H, ASP140I, ASP242I, ASP33H, ASP54H, ASP58H, GLN175I, GLN204I, GLN37H, GLU101H, GLU178I, GLU179I, GLU221I, GLU244I, GLY102H, GLY105H, GLY108H, GLY141I, GLY143I, GLY207I, GLY243I, HIS103H, HIS183I, HIS210I, ILE145I, ILE146I, ILE182I, ILE34H, ILE53H, LEU205I, LEU206I, LYS217I, LYS245I, LYS32H, LYS59H, LYS61H, MET111H, PHE180I, PHE246I, PRO147I, PRO249I, SER142I, SER144I, SER177I, THR203I, THR209I, THR213I, THR60H, TRP49H, TYR104H, TYR106H, TYR109H, TYR176I, TYR35H
• H-K: ALA74H, ALA81H, ARG199K, ASN166K, ASN79H, ASP58H, ASP75H, GLN84H, GLU202K, ILE72H, LYS21H, LYS220K, LYS32H, PRO198K, PRO200K, SER167K, SER169K, SER196K, SER197K, SER201K, SER23H, SER77H, SER78H, THR203K, THR205K, THR71H, THR73H, THR76H, THR80H, TYR82H, VAL204K
• J-K: ALA106J, ALA110K, ALA136J, ALA136K, ALA140K, ALA141K, ALA179K, ALA40J, ALA57J, ALA99K, ARG199K, ARG217J, ARG224K, ARG42K, ARG52K, ASN143J, ASN144J, ASN144K, ASN167J, ASN216J, ASN218J, ASN34J, ASP107K, ASP112K, ASP171J, ASP173J, ASP176J, ASP1J, ASP225K, ASP54K, ASP63K, CYS140J, CYS151K, CYS220J, CYS226K, CYS94J, CYS98K, GLN116K, GLN130J, GLN142K, GLN182K, GLN37K, GLN41K, GLN43J, GLN44J, GLN45K, GLN48J, GLN8K, GLN95J, GLN96J, GLU101K, GLU129J, GLU219J, GLU3J, GLU44K, GLU48K, GLU61J, GLY102K, GLY105J, GLY105K, GLY107J, GLY108K, GLY115K, GLY117K, GLY134J, GLY135J, GLY138K, GLY150K, GLY164J, GLY173K, GLY46K, GLY47J, GLY51K, HIS103K, HIS175K, ILE123J, ILE221K, ILE50K, ILE53K, ILE54J, LEU102J, LEU131J, LEU135K, LEU142J, LEU149K, LEU152K, LEU166J, LEU181K, LEU185J, LEU185K, LEU187J, LEU188K, LEU39J, LEU47K, LEU52J, LEU53J, LEU6K, LYS109J, LYS154K, LYS175J, LYS213J, LYS219K, LYS220K, LYS36J, LYS40K, LYS51J, LYS61K, LYS65K, MET111K, MET146K, MET181J, PHE104J, PHE124J, PHE141J, PHE145J, PHE177K, PHE215J, PHE66K, PRO101J, PRO125J, PRO126J, PRO134K, PRO137K, PRO178K, PRO50J, PRO64K, SER100K, SER122J, SER127J, SER128J, SER131K, SER133J, SER137J, SER139K, SER168J, SER171K, SER172K, SER180J, SER182J, SER183J, SER183K, SER189K, SER190K, SER191K, SER214J, SER33J, SER49J, SER62J, SER99J, THR103J, THR120J, THR132J, THR143K, THR148K, THR170J, THR176K, THR178J, THR184J, THR186J, THR187K, THR193K, THR59J, TRP114K, TRP165K, TRP169J, TRP38K, TRP41J, TRP49K, TRP56J, TYR100J, TYR104K, TYR106K, TYR109K, TYR113K, TYR133K, TYR179J, TYR186K, TYR192J, TYR31J, TYR35K, TYR38J, TYR42J, TYR55J, TYR62K, TYR92J, TYR93J, TYR97J, TYR97K, TYR98J, VAL121J, VAL132K, VAL138J, VAL139J, VAL147K, VAL153K, VAL165J, VAL174K, VAL180K, VAL192K, VAL222K, VAL39K, VAL91J, VAL95K
• J-L: ALA274L, ARG208L, ASN28J, ASN34J, ASP140L, ASP242L, ASP248L, ASP273L, GLN27J, GLN35J, GLN95J, GLN96J, GLU178L, GLU179L, GLU244L, GLU283L, GLY207L, GLY243L, GLY247L, HIS210L, ILE2J, LEU102J, LEU29J, LEU30J, LYS245L, LYS279L, PHE246L, PHE275L, PRO101J, PRO249L, SER142L, SER144L, SER280L, SER32J, SER33J, SER99J, THR209L, THR211L, THR241L, TRP56J, TYR100J, TYR31J, TYR38J, TYR97J, TYR98J
• K-L: ALA110K, ALA56K, ARG181L, ARG208L, ARG52K, ASN57K, ASP107K, ASP140L, ASP242L, ASP33K, ASP54K, ASP58K, GLN175L, GLN204L, GLN37K, GLU101K, GLU178L, GLU179L, GLU221L, GLU244L, GLY102K, GLY105K, GLY108K, GLY141L, GLY143L, GLY207L, GLY243L, HIS103K, HIS183L, HIS210L, ILE145L, ILE146L, ILE182L, ILE34K, ILE53K, LEU205L, LEU206L, LYS217L, LYS245L, LYS32K, LYS59K, LYS61K, MET111K, PHE180L, PHE246L, PRO147L, PRO249L, SER142L, SER144L, SER177L, THR203L, THR209L, THR213L, THR60K, TRP49K, TYR104K, TYR106K, TYR109K, TYR176L, TYR35K