3Q9B

crystal structure of apah complexed with m344

• Total interactions analyzed: 66
• Total true interactions: 27
• Strongest Interaction:
  • Chains: B-F
  • Int. Res.: 173
  • Norm. En. per Res.: -6.5579
• Hub Node: A(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-C	-17.866	-44.3041	-79.0978	-141.268	57	3	2	3991	2	11	10
A-D	0.0	0.0	-1.9882	-1.9882	8	0	0	86	0	6	3
A-E	0.0	0.0	-1.8789	-1.8789	8	0	0	83	0	6	2
A-I	-177.995	-261.4389	-663.687	-1103.1209	173	28	8	23800	18	62	58
A-J	-21.5494	8.137	-117.68	-131.0924	93	4	3	5837	0	33	35
B-C	0.0	0.0	-1.7553	-1.7553	10	0	0	82	0	6	2
B-E	-23.918	-56.8629	-83.5825	-164.3634	57	3	2	4081	4	12	10
B-F	-188.2904	-276.4021	-669.831	-1134.5236	173	28	8	23836	24	60	58
B-G	0.0	0.0	-1.9022	-1.9022	10	0	0	86	0	6	3
B-L	-23.434	8.6526	-126.238	-141.0194	90	5	3	5851	0	31	35
C-F	-19.8058	8.4481	-124.412	-135.7697	91	4	3	5968	0	33	35
C-G	0.0	0.0	-1.9558	-1.9558	8	0	0	80	0	6	2
C-K	-182.7708	-270.5402	-641.599	-1094.91	173	30	9	23794	15	60	58
D-E	0.0	0.0	-1.9895	-1.9895	10	0	0	86	0	7	2
D-G	-8.706	-46.9667	-82.8184	-138.4911	57	3	2	4040	2	12	10
D-H	-10.2729	9.5091	-128.292	-129.0559	92	3	3	6055	0	33	36
D-J	-168.1608	-268.2952	-656.074	-1092.53	175	30	8	23789	20	57	58
E-H	-171.9458	-262.35	-655.225	-1089.5208	173	29	8	23694	18	60	58
E-I	-17.2626	8.5692	-120.672	-129.3654	89	3	3	5805	0	33	35
F-K	0.0	0.0	-1.8595	-1.8595	9	0	0	82	0	6	2
F-L	0.0	0.0	-1.9267	-1.9267	7	0	0	85	0	8	2
G-K	-15.4985	8.3287	-124.397	-131.5668	92	4	3	6052	0	34	35
G-L	-165.0006	-269.1817	-667.423	-1101.6054	174	25	8	23718	19	62	58
H-I	0.0	0.0	-1.8862	-1.8862	10	0	0	83	0	6	2
H-J	0.0	0.0	-1.8685	-1.8685	7	0	0	84	0	8	2
I-J	0.0	0.0	-1.9728	-1.9728	10	0	0	83	0	5	2
K-L	0.0	0.0	-1.9903	-1.9903	9	0	0	85	0	6	2

Interface residues

• A-C: ALA310A, ALA310C, ALA340A, ALA340C, ARG306A, ARG306C, ASN334A, ASN334C, ASP300A, ASP300C, GLU260A, GLU260C, GLU287A, GLU287C, GLY305A, GLY338A, GLY338C, GLY341A, GLY341C, ILE302A, ILE302C, LEU296A, LEU296C, LYS295A, LYS295C, LYS337A, LYS337C, MET304A, MET304C, PHE286A, PHE286C, PRO254A, PRO254C, PRO299A, PRO299C, SER256A, SER256C, SER298A, SER298C, SER311A, SER311C, THR263A, THR263C, THR297A, THR297C, THR303A, THR303C, THR307A, THR307C, TYR255A, TYR255C, TYR301A, TYR301C, VAL257A, VAL257C, VAL339A, VAL339C
• A-D: ALA239A, ALA241A, ARG95D, GLU233D, GLY238A, GLY240A, GLY242A, TYR231D
• A-E: ALA239E, ALA241E, ARG95A, GLU233A, GLY238E, GLY240E, GLY242E, TYR231A
• A-I: ALA115A, ALA115I, ALA116A, ALA116I, ALA119A, ALA119I, ALA222A, ALA222I, ALA224A, ALA224I, ALA232A, ALA232I, ALA81A, ALA81I, ALA87A, ALA87I, ALA89A, ALA89I, ARG100A, ARG100I, ARG251A, ARG251I, ARG95A, ARG95I, ARG96A, ARG96I, ASN114A, ASN114I, ASN200A, ASN200I, ASN246A, ASN246I, ASP104A, ASP104I, ASP163A, ASP163I, ASP204A, ASP204I, ASP220A, ASP220I, ASP64A, ASP64I, CYS113A, CYS113I, GLN108A, GLN108I, GLN203A, GLN203I, GLU106A, GLU106I, GLU117A, GLU117I, GLU17A, GLU17I, GLU208A, GLU208I, GLU223A, GLU223I, GLU22A, GLU22I, GLU233A, GLU233I, GLU234A, GLU234I, GLU86A, GLU86I, GLY107A, GLY107I, GLY110A, GLY110I, GLY161A, GLY161I, GLY166A, GLY166I, GLY167A, GLY167I, GLY201A, GLY201I, GLY20A, GLY20I, GLY21A, GLY21I, GLY230A, GLY230I, GLY82A, GLY82I, GLY85A, GLY85I, HIS198A, HIS227A, HIS227I, HIS63A, HIS63I, ILE101A, ILE101I, ILE105A, ILE105I, ILE109A, ILE109I, ILE162A, ILE162I, ILE205A, ILE205I, ILE88A, ILE88I, LEU18A, LEU18I, LEU229A, LEU229I, LEU23A, LEU23I, LYS237A, LYS237I, LYS84A, LYS84I, MET164A, MET164I, PHE165A, PHE165I, PHE225A, PHE225I, PHE228A, PHE228I, PHE293A, PHE293I, PHE92A, PHE92I, PRO102A, PRO102I, PRO221A, PRO221I, PRO226A, PRO226I, PRO93A, PRO93I, PRO99A, PRO99I, SER91A, SER91I, SER98A, SER98I, THR103A, THR103I, THR118A, THR118I, THR16A, THR16I, THR90A, THR90I, THR97A, THR97I, TRP75A, TRP75I, TRP78A, TRP78I, TYR111A, TYR111I, TYR112A, TYR112I, TYR19A, TYR19I, TYR207A, TYR207I, TYR231A, TYR231I, TYR67A, TYR67I, TYR83A, TYR83I, VAL24A, VAL24I, VAL94A, VAL94I
• A-J: ALA186A, ALA186J, ALA239A, ALA239J, ALA241A, ALA241J, ALA65A, ALA65J, ARG100A, ARG100J, ARG209A, ARG209J, ARG77A, ARG77J, ASN69A, ASN69J, ASP104A, ASP183A, ASP183J, ASP211A, ASP211J, ASP64A, ASP64J, GLN108A, GLN108J, GLN179A, GLN179J, GLU208A, GLU208J, GLU57A, GLU57J, GLU72J, GLY185A, GLY210A, GLY210J, GLY236A, GLY236J, GLY238A, GLY238J, GLY240A, GLY240J, GLY242A, GLY242J, GLY55A, GLY55J, GLY66A, GLY66J, HIS54A, HIS54J, HIS63A, HIS63J, ILE101A, ILE101J, LEU182A, LEU182J, LEU56A, LEU56J, LEU60A, LEU60J, LEU68A, LEU68J, LYS184A, LYS187A, LYS187J, LYS188A, LYS188J, LYS237A, LYS237J, LYS61A, LYS61J, PHE272A, PHE272J, PHE70A, PRO99A, PRO99J, SER98A, SER98J, THR103A, THR103J, THR235A, THR235J, THR243A, THR243J, THR58A, THR58J, THR73A, THR73J, TYR111A, TYR111J, VAL59A, VAL59J, VAL62A, VAL62J
• B-C: ALA222B, ALA239C, ALA241C, ARG95B, GLU233B, GLY238C, GLY240C, GLY242C, LYS188C, TYR231B
• B-E: ALA310B, ALA310E, ALA340B, ALA340E, ARG306B, ARG306E, ASN334B, ASN334E, ASP300B, ASP300E, GLU260B, GLU260E, GLU287B, GLU287E, GLY305B, GLY305E, GLY338B, GLY338E, GLY341B, GLY341E, ILE302B, ILE302E, LEU296B, LEU296E, LYS295B, LYS295E, LYS337B, LYS337E, MET304B, MET304E, PHE286B, PHE286E, PRO254B, PRO254E, PRO299B, PRO299E, SER256B, SER256E, SER298B, SER298E, SER311B, SER311E, THR263B, THR263E, THR297B, THR297E, THR303B, THR303E, THR307B, THR307E, TYR255B, TYR255E, TYR301B, TYR301E, VAL257B, VAL339B, VAL339E
• B-F: ALA115B, ALA115F, ALA116B, ALA116F, ALA119B, ALA119F, ALA222B, ALA222F, ALA224B, ALA224F, ALA232B, ALA232F, ALA81B, ALA81F, ALA87B, ALA87F, ALA89B, ALA89F, ARG100B, ARG100F, ARG251B, ARG251F, ARG95B, ARG95F, ARG96B, ARG96F, ASN114B, ASN114F, ASN200B, ASN200F, ASN246B, ASN246F, ASP104B, ASP104F, ASP163B, ASP163F, ASP204B, ASP204F, ASP220B, ASP220F, ASP64B, ASP64F, CYS113B, CYS113F, GLN108B, GLN108F, GLN203B, GLN203F, GLU106B, GLU106F, GLU117B, GLU117F, GLU17B, GLU17F, GLU208B, GLU208F, GLU223B, GLU223F, GLU22B, GLU22F, GLU233B, GLU233F, GLU234B, GLU234F, GLU86B, GLU86F, GLY107B, GLY107F, GLY110B, GLY110F, GLY161B, GLY161F, GLY166B, GLY166F, GLY167B, GLY167F, GLY201B, GLY201F, GLY20B, GLY20F, GLY21B, GLY21F, GLY230B, GLY230F, GLY82B, GLY82F, GLY85B, GLY85F, HIS227B, HIS227F, HIS63B, HIS63F, ILE101B, ILE101F, ILE105B, ILE105F, ILE109B, ILE109F, ILE162B, ILE162F, ILE205B, ILE205F, ILE88B, ILE88F, LEU18B, LEU18F, LEU229B, LEU229F, LEU23B, LEU23F, LYS237B, LYS237F, LYS84B, LYS84F, MET164B, MET164F, PHE165B, PHE165F, PHE225B, PHE225F, PHE228B, PHE228F, PHE27F, PHE293B, PHE293F, PHE92B, PHE92F, PRO102B, PRO102F, PRO221B, PRO221F, PRO226B, PRO226F, PRO93B, PRO93F, PRO99B, PRO99F, SER91B, SER91F, SER98B, SER98F, THR103B, THR103F, THR118B, THR118F, THR16B, THR16F, THR90B, THR90F, THR97B, THR97F, TRP75B, TRP75F, TRP78B, TRP78F, TYR111B, TYR111F, TYR112B, TYR112F, TYR19B, TYR19F, TYR207B, TYR207F, TYR231B, TYR231F, TYR67B, TYR67F, TYR83B, TYR83F, VAL24B, VAL24F, VAL94B, VAL94F
• B-G: ALA222G, ALA239B, ALA241B, ARG95G, GLU233G, GLY238B, GLY240B, GLY242B, LYS188B, TYR231G
• B-L: ALA186B, ALA186L, ALA239B, ALA239L, ALA241B, ALA241L, ALA65B, ALA65L, ARG100B, ARG100L, ARG209B, ARG209L, ARG77B, ARG77L, ASN69B, ASN69L, ASP183B, ASP183L, ASP211B, ASP211L, ASP64B, ASP64L, GLN108B, GLN108L, GLN179B, GLN179L, GLU208B, GLU208L, GLU57B, GLU57L, GLU72L, GLY185B, GLY210B, GLY210L, GLY236B, GLY236L, GLY238B, GLY238L, GLY240B, GLY240L, GLY242B, GLY242L, GLY55B, GLY55L, GLY66B, GLY66L, HIS54B, HIS54L, HIS63B, HIS63L, ILE101B, ILE101L, LEU182B, LEU182L, LEU56B, LEU56L, LEU60B, LEU60L, LEU68B, LEU68L, LYS187B, LYS187L, LYS188B, LYS188L, LYS237B, LYS237L, LYS61B, LYS61L, PHE272B, PHE272L, PHE70B, PRO99B, PRO99L, SER98B, SER98L, THR103B, THR103L, THR235B, THR243B, THR243L, THR58B, THR58L, THR73B, THR73L, TYR111B, TYR111L, VAL59B, VAL59L, VAL62B, VAL62L
• C-F: ALA186C, ALA186F, ALA239C, ALA239F, ALA241C, ALA241F, ALA65C, ALA65F, ARG100C, ARG100F, ARG209C, ARG209F, ARG77C, ARG77F, ASN69C, ASN69F, ASP183C, ASP183F, ASP211C, ASP211F, ASP64C, ASP64F, GLN108C, GLN108F, GLN179C, GLN179F, GLU208C, GLU208F, GLU57C, GLU57F, GLU72C, GLU72F, GLY185C, GLY210C, GLY210F, GLY236C, GLY236F, GLY238C, GLY238F, GLY240C, GLY240F, GLY242C, GLY242F, GLY55C, GLY55F, GLY66C, GLY66F, HIS54C, HIS54F, HIS63C, HIS63F, ILE101C, ILE101F, LEU182C, LEU182F, LEU56C, LEU56F, LEU60C, LEU60F, LEU68C, LEU68F, LYS187C, LYS187F, LYS188C, LYS188F, LYS237C, LYS237F, LYS61C, LYS61F, PHE272C, PHE272F, PHE70F, PRO99C, PRO99F, SER98C, SER98F, THR103C, THR103F, THR235C, THR243C, THR243F, THR58C, THR58F, THR73C, THR73F, TYR111C, TYR111F, VAL59C, VAL59F, VAL62C, VAL62F
• C-G: ALA239G, ALA241G, ARG95C, GLU233C, GLY238G, GLY240G, GLY242G, TYR231C
• C-K: ALA115C, ALA115K, ALA116C, ALA116K, ALA119C, ALA119K, ALA222C, ALA222K, ALA224C, ALA224K, ALA232C, ALA232K, ALA81C, ALA81K, ALA87C, ALA87K, ALA89C, ALA89K, ARG100C, ARG100K, ARG251C, ARG251K, ARG95C, ARG95K, ARG96C, ARG96K, ASN114C, ASN114K, ASN200C, ASN200K, ASN246C, ASP104C, ASP104K, ASP163C, ASP163K, ASP204C, ASP204K, ASP220C, ASP220K, ASP64C, ASP64K, CYS113C, CYS113K, GLN108C, GLN108K, GLN203C, GLN203K, GLU106C, GLU106K, GLU117C, GLU117K, GLU17C, GLU17K, GLU208C, GLU208K, GLU223C, GLU223K, GLU22C, GLU22K, GLU233C, GLU233K, GLU234C, GLU234K, GLU86C, GLU86K, GLY107C, GLY107K, GLY110C, GLY110K, GLY161C, GLY161K, GLY166C, GLY166K, GLY167C, GLY167K, GLY201C, GLY201K, GLY20C, GLY20K, GLY21C, GLY21K, GLY230C, GLY230K, GLY82C, GLY82K, GLY85C, GLY85K, HIS227C, HIS227K, HIS63C, HIS63K, ILE101C, ILE101K, ILE105C, ILE105K, ILE109C, ILE109K, ILE162C, ILE162K, ILE205C, ILE205K, ILE88C, ILE88K, LEU18C, LEU18K, LEU229C, LEU229K, LEU23C, LEU23K, LYS15C, LYS237C, LYS237K, LYS84C, LYS84K, MET164C, MET164K, PHE165C, PHE165K, PHE225C, PHE225K, PHE228C, PHE228K, PHE27C, PHE293C, PHE293K, PHE92C, PHE92K, PRO102C, PRO102K, PRO221C, PRO221K, PRO226C, PRO226K, PRO93C, PRO93K, PRO99C, PRO99K, SER91C, SER91K, SER98C, SER98K, THR103C, THR103K, THR118C, THR118K, THR16C, THR16K, THR90C, THR90K, THR97C, THR97K, TRP75C, TRP75K, TRP78C, TRP78K, TYR111C, TYR111K, TYR112C, TYR112K, TYR19C, TYR19K, TYR207C, TYR207K, TYR231C, TYR231K, TYR67C, TYR67K, TYR83C, TYR83K, VAL24C, VAL24K, VAL94C, VAL94K
• D-E: ALA222E, ALA239D, ALA241D, ARG95E, GLU233E, GLY238D, GLY240D, GLY242D, LYS188D, TYR231E
• D-G: ALA309G, ALA310D, ALA310G, ALA340D, ALA340G, ARG306D, ARG306G, ASN334D, ASN334G, ASP300D, ASP300G, GLU260D, GLU260G, GLU287D, GLU287G, GLY305G, GLY338D, GLY338G, GLY341D, GLY341G, ILE302D, ILE302G, LEU296D, LEU296G, LYS295D, LYS295G, LYS337D, LYS337G, MET304D, MET304G, PHE286D, PHE286G, PRO254D, PRO254G, PRO299D, PRO299G, SER256D, SER256G, SER298D, SER298G, SER311D, SER311G, THR263D, THR263G, THR297D, THR297G, THR303D, THR303G, THR307D, THR307G, TYR255D, TYR255G, TYR301D, TYR301G, VAL257D, VAL339D, VAL339G
• D-H: ALA186D, ALA186H, ALA239D, ALA239H, ALA241D, ALA241H, ALA65D, ALA65H, ARG100D, ARG100H, ARG209D, ARG209H, ARG77D, ARG77H, ASN69D, ASN69H, ASP104D, ASP183D, ASP183H, ASP211D, ASP211H, ASP64D, ASP64H, GLN108D, GLN108H, GLN179D, GLN179H, GLU208D, GLU208H, GLU57D, GLU57H, GLU72D, GLU72H, GLY210D, GLY210H, GLY236D, GLY236H, GLY238D, GLY238H, GLY240D, GLY240H, GLY242D, GLY242H, GLY55D, GLY55H, GLY66D, GLY66H, HIS54D, HIS54H, HIS63D, HIS63H, ILE101D, ILE101H, LEU182D, LEU182H, LEU56D, LEU56H, LEU60D, LEU60H, LEU68D, LEU68H, LYS187D, LYS187H, LYS188D, LYS188H, LYS237D, LYS237H, LYS61D, LYS61H, PHE272D, PHE272H, PHE70D, PRO99D, PRO99H, SER98D, SER98H, THR103D, THR103H, THR235D, THR235H, THR243D, THR243H, THR58D, THR58H, THR73D, THR73H, TYR111D, TYR111H, VAL59D, VAL59H, VAL62D, VAL62H
• D-J: ALA115D, ALA115J, ALA116D, ALA116J, ALA119D, ALA119J, ALA222D, ALA222J, ALA224D, ALA224J, ALA232D, ALA232J, ALA81D, ALA81J, ALA87D, ALA87J, ALA89D, ALA89J, ARG100D, ARG100J, ARG251D, ARG251J, ARG95D, ARG95J, ARG96D, ARG96J, ASN114D, ASN114J, ASN200D, ASN200J, ASN246D, ASN246J, ASP104D, ASP104J, ASP163D, ASP163J, ASP204D, ASP204J, ASP220D, ASP220J, ASP64D, ASP64J, CYS113D, CYS113J, GLN108D, GLN108J, GLN203D, GLN203J, GLU106D, GLU106J, GLU117D, GLU117J, GLU17D, GLU17J, GLU208D, GLU208J, GLU223D, GLU223J, GLU22D, GLU22J, GLU233D, GLU233J, GLU234D, GLU234J, GLU86D, GLU86J, GLY107D, GLY107J, GLY110D, GLY110J, GLY161D, GLY161J, GLY166D, GLY166J, GLY167D, GLY167J, GLY201D, GLY201J, GLY20D, GLY20J, GLY21D, GLY21J, GLY230D, GLY230J, GLY82D, GLY82J, GLY85D, GLY85J, HIS227D, HIS227J, HIS63D, HIS63J, ILE101D, ILE101J, ILE105D, ILE105J, ILE109D, ILE109J, ILE162D, ILE162J, ILE205D, ILE205J, ILE88D, ILE88J, LEU18D, LEU18J, LEU229D, LEU229J, LEU23D, LEU23J, LYS15D, LYS237D, LYS237J, LYS84D, LYS84J, MET164D, MET164J, PHE165D, PHE165J, PHE225D, PHE225J, PHE228D, PHE228J, PHE27D, PHE27J, PHE293D, PHE293J, PHE92D, PHE92J, PRO102D, PRO102J, PRO221D, PRO221J, PRO226D, PRO226J, PRO93D, PRO93J, PRO99D, PRO99J, SER91D, SER91J, SER98D, SER98J, THR103D, THR103J, THR118D, THR118J, THR16D, THR16J, THR90D, THR90J, THR97D, THR97J, TRP75D, TRP75J, TRP78D, TRP78J, TYR111D, TYR111J, TYR112D, TYR112J, TYR19D, TYR19J, TYR207D, TYR207J, TYR231D, TYR231J, TYR67D, TYR67J, TYR83D, TYR83J, VAL24D, VAL24J, VAL94D, VAL94J
• E-H: ALA115E, ALA115H, ALA116E, ALA116H, ALA119E, ALA119H, ALA222E, ALA222H, ALA224E, ALA224H, ALA232E, ALA232H, ALA81E, ALA81H, ALA87E, ALA87H, ALA89E, ALA89H, ARG100E, ARG100H, ARG251E, ARG251H, ARG95E, ARG95H, ARG96E, ARG96H, ASN114E, ASN114H, ASN200E, ASN200H, ASN246E, ASN246H, ASP104E, ASP104H, ASP163E, ASP163H, ASP204E, ASP204H, ASP220E, ASP220H, ASP64E, ASP64H, CYS113E, CYS113H, GLN108E, GLN108H, GLN203E, GLN203H, GLU106E, GLU106H, GLU117E, GLU117H, GLU17E, GLU17H, GLU208E, GLU208H, GLU223E, GLU223H, GLU22E, GLU22H, GLU233E, GLU233H, GLU234E, GLU234H, GLU86E, GLU86H, GLY107E, GLY107H, GLY110E, GLY110H, GLY161E, GLY161H, GLY166E, GLY166H, GLY167E, GLY167H, GLY201E, GLY201H, GLY20E, GLY20H, GLY21E, GLY21H, GLY230E, GLY230H, GLY82E, GLY82H, GLY85E, GLY85H, HIS227E, HIS227H, HIS63E, HIS63H, ILE101E, ILE101H, ILE105E, ILE105H, ILE109E, ILE109H, ILE162E, ILE162H, ILE205E, ILE205H, ILE88E, ILE88H, LEU18E, LEU18H, LEU229E, LEU229H, LEU23E, LEU23H, LYS15H, LYS237E, LYS237H, LYS84E, LYS84H, MET164E, MET164H, PHE165E, PHE165H, PHE225E, PHE225H, PHE228E, PHE228H, PHE293E, PHE293H, PHE92E, PHE92H, PRO102E, PRO102H, PRO221E, PRO221H, PRO226E, PRO226H, PRO93E, PRO93H, PRO99E, PRO99H, SER91E, SER91H, SER98E, SER98H, THR103E, THR103H, THR118E, THR118H, THR16E, THR16H, THR90E, THR90H, THR97E, THR97H, TRP75E, TRP75H, TRP78E, TRP78H, TYR111E, TYR111H, TYR112E, TYR112H, TYR19E, TYR19H, TYR207E, TYR207H, TYR231E, TYR231H, TYR67E, TYR67H, TYR83E, TYR83H, VAL24E, VAL24H, VAL94E, VAL94H
• E-I: ALA186E, ALA186I, ALA239E, ALA239I, ALA241E, ALA241I, ALA65E, ALA65I, ARG100E, ARG100I, ARG209E, ARG209I, ARG77E, ARG77I, ASN69E, ASN69I, ASP104I, ASP183E, ASP183I, ASP211E, ASP211I, ASP64E, ASP64I, GLN108E, GLN108I, GLN179E, GLN179I, GLU208E, GLU208I, GLU57E, GLU57I, GLY210E, GLY210I, GLY236E, GLY236I, GLY238E, GLY238I, GLY240E, GLY240I, GLY242E, GLY242I, GLY55E, GLY55I, GLY66E, GLY66I, HIS54E, HIS54I, HIS63E, HIS63I, ILE101E, ILE101I, LEU182E, LEU182I, LEU56E, LEU56I, LEU60E, LEU60I, LEU68E, LEU68I, LYS187E, LYS187I, LYS188E, LYS188I, LYS237E, LYS237I, LYS61E, LYS61I, PHE272E, PHE272I, PRO99E, PRO99I, SER98E, SER98I, THR103E, THR103I, THR235E, THR235I, THR243E, THR243I, THR58E, THR58I, THR73E, THR73I, TYR111E, TYR111I, VAL59E, VAL59I, VAL62E, VAL62I
• F-K: ALA222K, ALA239F, ALA241F, ARG95K, GLU233K, GLY238F, GLY240F, GLY242F, LYS188F
• F-L: ALA239L, ALA241L, ARG95F, GLU233F, GLY238L, GLY240L, GLY242L
• G-K: ALA186G, ALA186K, ALA239G, ALA239K, ALA241G, ALA241K, ALA65G, ALA65K, ARG100G, ARG100K, ARG209G, ARG209K, ARG77G, ARG77K, ASN69G, ASN69K, ASP183G, ASP183K, ASP211G, ASP211K, ASP64G, ASP64K, GLN108G, GLN108K, GLN179G, GLN179K, GLU208G, GLU208K, GLU57G, GLU57K, GLU72G, GLU72K, GLY210G, GLY210K, GLY236G, GLY236K, GLY238G, GLY238K, GLY240G, GLY240K, GLY242G, GLY242K, GLY55G, GLY55K, GLY66G, GLY66K, HIS54G, HIS54K, HIS63G, HIS63K, ILE101G, ILE101K, LEU182G, LEU182K, LEU56G, LEU56K, LEU60G, LEU60K, LEU68G, LEU68K, LYS187G, LYS187K, LYS188G, LYS188K, LYS237G, LYS237K, LYS61G, LYS61K, PHE272G, PHE272K, PHE70G, PHE70K, PRO99G, PRO99K, SER98G, SER98K, THR103G, THR103K, THR235G, THR235K, THR243G, THR243K, THR58G, THR58K, THR73G, THR73K, TYR111G, TYR111K, VAL59G, VAL59K, VAL62G, VAL62K
• G-L: ALA115G, ALA115L, ALA116G, ALA116L, ALA119G, ALA119L, ALA222G, ALA222L, ALA224G, ALA224L, ALA232G, ALA232L, ALA81G, ALA81L, ALA87G, ALA87L, ALA89G, ALA89L, ARG100G, ARG100L, ARG251G, ARG251L, ARG95G, ARG95L, ARG96G, ARG96L, ASN114G, ASN114L, ASN200G, ASN200L, ASN246G, ASN246L, ASP104G, ASP104L, ASP163G, ASP163L, ASP204G, ASP204L, ASP220G, ASP220L, ASP64G, ASP64L, CYS113G, CYS113L, GLN108G, GLN108L, GLN203G, GLN203L, GLU106G, GLU106L, GLU117G, GLU117L, GLU17G, GLU17L, GLU208G, GLU208L, GLU223G, GLU223L, GLU22G, GLU22L, GLU233G, GLU233L, GLU234G, GLU234L, GLU86G, GLU86L, GLY107G, GLY107L, GLY110G, GLY110L, GLY161G, GLY161L, GLY166G, GLY166L, GLY167G, GLY167L, GLY201G, GLY201L, GLY20G, GLY20L, GLY21G, GLY21L, GLY230G, GLY230L, GLY82G, GLY82L, GLY85G, GLY85L, HIS227G, HIS227L, HIS63G, HIS63L, ILE101G, ILE101L, ILE105G, ILE105L, ILE109G, ILE109L, ILE162G, ILE162L, ILE205G, ILE205L, ILE88G, ILE88L, LEU18G, LEU18L, LEU229G, LEU229L, LEU23G, LEU23L, LYS15L, LYS237G, LYS237L, LYS84G, LYS84L, MET164G, MET164L, PHE165G, PHE165L, PHE225G, PHE225L, PHE228G, PHE228L, PHE27G, PHE293G, PHE293L, PHE92G, PHE92L, PRO102G, PRO102L, PRO221G, PRO221L, PRO226G, PRO226L, PRO93G, PRO93L, PRO99G, PRO99L, SER91G, SER91L, SER98G, SER98L, THR103G, THR103L, THR118G, THR118L, THR16G, THR16L, THR90G, THR90L, THR97G, THR97L, TRP75G, TRP75L, TRP78G, TRP78L, TYR111G, TYR111L, TYR112G, TYR112L, TYR19G, TYR19L, TYR207G, TYR207L, TYR231G, TYR231L, TYR67G, TYR67L, TYR83G, TYR83L, VAL24G, VAL24L, VAL94G, VAL94L
• H-I: ALA222H, ALA239I, ALA241I, ARG95H, GLU233H, GLY238I, GLY240I, GLY242I, LYS188I, TYR231H
• H-J: ALA239H, ALA241H, ARG95J, GLU233J, GLY238H, GLY240H, GLY242H
• I-J: ALA222I, ALA239J, ALA241J, ARG95I, GLU233I, GLY238J, GLY240J, GLY242J, LYS188J, TYR231I
• K-L: ALA222L, ALA239K, ALA241K, ARG95L, GLU233L, GLY238K, GLY240K, GLY242K, LYS188K