3Q6F

crystal structure of fab of human mab 2909 specific for quaternary neutralizing epitope of hiv-1 gp120

• Total interactions analyzed: 66
• Total true interactions: 29
• Strongest Interaction:
  • Chains: H-J
  • Int. Res.: 54
  • Norm. En. per Res.: -3.4797
• Hub Node: C(8)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-7.2758	-38.4005	246.113	200.4367	189	19	11	18912	4	28	25
A-D	-12.7544	-9.5619	-69.4406	-91.7569	38	5	0	2725	0	15	8
A-G	0.0	0.0	-12.8375	-12.8375	36	0	0	900	0	6	3
A-H	0.0	0.0	-2.6374	-2.6374	14	0	0	273	0	1	1
B-G	0.0	0.0	-1.1059	-1.1059	10	0	0	218	0	0	0
B-H	0.0	0.0	-0.001	-0.001	2	0	0	3	0	0	0
C-D	-6.2107	-35.5879	251.205	209.4064	185	18	12	18651	4	29	27
C-E	0.0	0.0	-0.1215	-0.1215	2	0	0	20	0	1	0
C-F	0.0	0.0	-3.3708	-3.3708	9	0	0	196	0	0	0
C-G	0.0	1.714	-4.0902	-2.3762	13	0	0	318	0	5	3
C-I	0.0	1.2845	-42.3465	-41.062	46	3	0	2363	0	6	5
C-J	0.0	-4.963	-5.6504	-10.6134	13	0	0	341	0	1	1
C-K	0.0	0.0	-0.0093	-0.0093	6	0	0	9	0	0	1
C-L	-24.9361	-2.5639	-19.658	-47.158	27	5	0	1650	0	7	3
D-E	-7.4292	0.0	-32.2283	-39.6575	21	5	0	1611	0	0	0
D-F	-3.4657	-21.1277	-29.4834	-54.0767	33	2	0	1132	2	4	0
D-G	0.0	0.0	-12.3984	-12.3984	22	0	0	717	0	3	5
D-H	0.0	0.0	-0.0256	-0.0256	2	0	0	9	0	0	0
D-K	-27.4591	-2.5255	-51.8314	-81.816	29	8	0	2064	0	7	4
D-L	-81.8567	2.7755	-105.311	-184.3921	56	9	1	4310	0	18	26
E-F	-10.7002	-43.0731	317.648	263.8747	187	28	12	18379	3	28	25
F-L	0.0	-2.5984	-22.3441	-24.9425	33	11	0	1711	0	2	2
G-H	-6.0863	-35.0194	235.614	194.5083	185	19	11	19104	3	28	26
G-I	0.0	0.0	-0.0551	-0.0551	6	0	0	39	0	0	1
G-J	-11.5633	-3.3563	-42.7435	-57.663	26	2	0	1805	0	6	4
H-I	-14.2414	-3.1532	-48.4919	-65.8865	27	4	0	1929	0	7	4
H-J	-82.9728	3.5918	-108.523	-187.904	54	10	1	4420	0	18	26
I-J	-6.9972	-36.8541	213.954	170.1027	188	24	11	19415	4	28	27
K-L	-5.5901	-41.6235	283.814	236.6005	189	21	11	18506	5	28	27

Interface residues

• A-B: ALA125B, ALA127A, ALA130A, ALA136B, ALA137B, ALA168B, ALA173A, ALA174A, ALA207A, ALA43A, ALA60B, ALA93B, ARG38B, ARG54A, ARG56B, ASN169A, ASN30A, ASN32A, ASP100B, ASP101B, ASP138A, ASP144B, ASP53A, ASP61B, ASP85A, ASP92A, ASP95A, ASP95B, ASP98B, CYS134A, CYS140B, CYS211A, CYS216B, CYS88A, CYS92B, GLN126A, GLN167A, GLN171B, GLN37A, GLN38A, GLN39B, GLN42A, GLN46B, GLN89A, GLU123A, GLU124A, GLU160A, GLU210A, GLY100A, GLY101A, GLY102B, GLY104B, GLY106B, GLY139B, GLY158A, GLY162B, GLY41A, GLY42B, GLY44B, GLY97B, GLY99A, HIS164B, HIS34A, HIS35B, HIS95A, ILE136A, ILE48A, LEU117A, LEU124B, LEU125A, LEU132A, LEU135A, LEU138B, LEU141B, LEU170B, LEU175B, LEU178A, LEU178B, LEU180A, LEU45B, LEU46A, LEU4B, LEU50B, LYS105B, LYS129A, LYS143B, LYS163A, LYS166A, LYS171A, LYS209B, LYS210B, LYS214B, LYS31A, LYS43B, LYS64B, LYS94B, LYS96B, MET100B, PHE100B, PHE118A, PHE122B, PHE139A, PHE166B, PHE89B, PHE91B, PHE98A, PRO119A, PRO120A, PRO123B, PRO126B, PRO164A, PRO167B, PRO208A, PRO40A, PRO41B, PRO44A, PRO55A, SER100B, SER114A, SER120B, SER121A, SER122A, SER127B, SER128B, SER137A, SER161B, SER165A, SER168A, SER172B, SER173B, SER175A, SER176A, SER177B, SER179A, SER179B, SER180B, SER215B, SER49B, SER56A, SER62B, SER93A, SER95A, SER99B, THR116A, THR131A, THR160B, THR161A, THR162A, THR165B, THR183B, THR57B, TRP103B, TRP185A, TRP35A, TRP36B, TRP47B, TRP91A, TYR100B, TYR145B, TYR172A, TYR177A, TYR2A, TYR36A, TYR49A, TYR50A, TYR58B, TYR59B, TYR86A, TYR87A, VAL115A, VAL121B, VAL133A, VAL142B, VAL159A, VAL163B, VAL169B, VAL181B, VAL182B, VAL206A, VAL211B, VAL33A, VAL37B, VAL45A, VAL47A, VAL48B, VAL63B, VAL90A, VAL96A, VAL97A
• A-D: ALA111A, ALA112A, ARG56D, ASN53D, ASN73D, ASP100D, ASP30D, ASP31D, GLN108A, GLU198A, GLY199A, GLY54D, GLY55D, GLY97D, HIS197A, LEU106A, LYS110A, PHE139A, PHE29D, PRO109A, PRO113A, PRO141A, SER12A, SER200A, SER28D, SER32D, SER52D, SER99D, SER9A, THR196A, THR201A, THR33D, THR57D, TRP52D, TYR100D, TYR140A, VAL11A, VAL202A
• A-G: ALA147A, ARG189G, ASN26G, ASN94A, ASP151G, ASP92A, ASP95A, GLN194A, GLN194G, GLN6A, GLU203G, GLY152G, GLY199A, HIS95A, HIS95G, LYS149A, LYS149G, LYS156A, LYS156G, PRO154G, PRO7A, PRO8A, SER153G, SER93A, SER95A, SER95G, SER9A, THR145A, THR196A, THR201A, THR201G, THR5G, TYR2A, TYR2G, VAL3G, VAL97G
• A-H: ALA29A, ARG66H, ASN26A, ASN27A, ASN30A, ASN69A, ASN94A, ASP61H, GLU85H, GLY68A, LYS83H, SER62H, SER93A, THR84H
• B-G: ASN26G, ASN69G, ASP61B, GLY24G, GLY25G, GLY65B, LYS64B, THR5G, TYR58B, VAL3G
• B-H: LEU100B, LYS64H
• C-D: ALA125D, ALA127C, ALA130C, ALA136D, ALA137D, ALA168D, ALA173C, ALA174C, ALA43C, ALA60D, ALA93D, ARG38D, ARG54C, ARG56D, ASN169C, ASN30C, ASN32C, ASP100D, ASP101D, ASP138C, ASP144D, ASP51C, ASP53C, ASP61D, ASP85C, ASP92C, ASP95C, ASP95D, ASP98D, CYS134C, CYS140D, CYS211C, CYS216D, CYS88C, CYS92D, GLN126C, GLN167C, GLN171D, GLN37C, GLN38C, GLN39D, GLN42C, GLN46D, GLN89C, GLU123C, GLU124C, GLU160C, GLU210C, GLY100C, GLY101C, GLY102D, GLY104D, GLY106D, GLY139D, GLY158C, GLY162D, GLY41C, GLY42D, GLY44D, GLY97D, GLY99C, HIS164D, HIS34C, HIS35D, HIS95C, ILE136C, ILE48C, LEU117C, LEU124D, LEU125C, LEU132C, LEU135C, LEU138D, LEU141D, LEU170D, LEU175D, LEU178C, LEU178D, LEU180C, LEU45D, LEU46C, LEU4D, LEU50D, LYS105D, LYS129C, LYS143D, LYS163C, LYS166C, LYS171C, LYS209D, LYS210D, LYS214D, LYS31C, LYS43D, LYS64D, LYS94D, LYS96D, MET100D, PHE100D, PHE118C, PHE122D, PHE139C, PHE166D, PHE89D, PHE91D, PHE98C, PRO119C, PRO120C, PRO123D, PRO126D, PRO164C, PRO167D, PRO40C, PRO41D, PRO44C, PRO55C, SER100D, SER114C, SER120D, SER121C, SER122C, SER127D, SER128D, SER137C, SER161D, SER165C, SER168C, SER172D, SER173D, SER175C, SER176C, SER177D, SER179C, SER179D, SER180D, SER215D, SER49D, SER56C, SER62D, SER93C, SER95C, SER99D, THR116C, THR131C, THR160D, THR161C, THR162C, THR165D, THR183D, THR57D, TRP103D, TRP35C, TRP36D, TRP47D, TRP91C, TYR100D, TYR145D, TYR172C, TYR177C, TYR36C, TYR49C, TYR50C, TYR58D, TYR59D, TYR86C, TYR87C, VAL115C, VAL121D, VAL133C, VAL142D, VAL159C, VAL163D, VAL169D, VAL181D, VAL182D, VAL206C, VAL211D, VAL33C, VAL37D, VAL45C, VAL48D, VAL63D, VAL90C, VAL96C, VAL97C
• C-E: GLU79E, SER168C
• C-F: ALA158F, GLY162F, GLY57C, ILE58C, LEU159F, PRO55C, SER161F, SER56C, THR160F
• C-G: ASN128G, ASN94C, ASP95C, GLN126G, GLU183G, LEU125G, LYS186G, PRO182G, SER187G, SER93C, SER95C, THR181G, TRP91C
• C-I: ALA150C, ALA157C, ALA157I, ALA29C, ARG189C, ASN26C, ASN26I, ASN27C, ASN27I, ASN30C, ASN30I, ASN69C, ASN94I, ASP151C, ASP92I, GLN184C, GLN184I, GLN194C, GLY152C, GLY158I, GLY68C, HIS188C, HIS95I, ILE28C, LEU180I, LYS129I, LYS149C, LYS156C, LYS156I, LYS31I, PRO154C, SER153C, SER179I, SER190C, SER67C, SER93I, SER95I, THR181I, THR70C, TRP148C, TYR191C, TYR2I, VAL155C, VAL155I, VAL159I, VAL3I
• C-J: ALA157C, ASN100J, ASN26C, ASN27C, ASN69C, ASP61J, HIS188C, LEU100J, LYS156C, LYS64J, SER172J, SER173J, SER187C
• C-K: ALA127C, ALA127K, ASN128C, ASN128K, LYS129C, LYS129K
• C-L: ALA114L, ALA127C, ASN128C, ASN204L, ASP144L, GLN126C, GLU123C, GLU124C, GLY118L, GLY174L, HIS200L, LEU125C, LEU175L, LYS117L, PHE146L, PRO119L, PRO202L, SER112L, SER113L, SER115L, SER120L, SER122C, SER173L, SER203L, THR116L, THR205L, TYR145L
• D-E: ALA158D, ARG54E, ARG61E, ARG77E, ASN155D, ASN197D, ASP60E, GLU79E, GLY157D, GLY57E, ILE58E, LEU159D, PHE62E, PRO55E, PRO59E, SER153D, SER156D, SER161D, SER56E, THR160D, TRP154D
• D-F: ALA158F, ALA24D, ASN155F, ASN197F, ASN199D, ASN199F, ASN204D, ASN76D, GLN3D, GLN3F, GLU1D, GLU1F, GLY157F, GLY26D, GLY26F, LEU159F, LYS201D, LYS201F, LYS206D, PHE27D, SER153F, SER156F, SER161F, SER25D, SER28D, THR151F, THR160F, THR205D, TRP154F, VAL152F, VAL163F, VAL2D, VAL2F
• D-G: ALA157G, ARG56D, ASN100D, ASP100D, GLN184G, GLU183G, GLY100D, GLY158G, HIS188G, LEU100D, LEU178G, LEU180G, LYS156G, LYS186G, SER100D, SER179G, SER187G, THR181G, TYR100D, TYR58D, VAL155G, VAL159G
• D-H: ASN100D, SER172H
• D-K: ALA114D, ALA127K, ASN128K, ASN204D, ASP144D, GLN126K, GLU123K, GLU124K, GLY118D, GLY174D, HIS200D, LEU125K, LEU175D, LYS117D, LYS129K, PHE146D, PRO119D, PRO202D, SER112D, SER113D, SER115D, SER120D, SER121K, SER122K, SER173D, SER203D, THR116D, THR205D, TYR145D
• D-L: ASN197D, ASN197L, ASN199D, ASN204D, ASN204L, ASP208D, ASP208L, CYS196D, CYS196L, GLU212D, GLU212L, GLY118D, GLY118L, HIS200D, HIS200L, ILE195D, ILE195L, LYS117D, LYS117L, LYS201D, LYS201L, LYS206D, LYS206L, LYS209D, LYS209L, LYS210D, LYS210L, LYS214D, PHE122D, PHE122L, PRO119D, PRO119L, PRO123D, PRO123L, PRO202D, PRO202L, SER120D, SER120L, SER203D, SER203L, THR116D, THR116L, THR193D, THR193L, THR205D, THR205L, TYR194D, TYR194L, VAL121D, VAL121L, VAL198D, VAL198L, VAL207D, VAL207L, VAL211D, VAL211L
• E-F: ALA125F, ALA127E, ALA130E, ALA136F, ALA137F, ALA168F, ALA173E, ALA174E, ALA40F, ALA43E, ALA60F, ALA93F, ARG38F, ARG54E, ARG56F, ASN128E, ASN169E, ASN32E, ASP100F, ASP101F, ASP138E, ASP144F, ASP51E, ASP53E, ASP61F, ASP85E, ASP92E, ASP95E, ASP95F, ASP98F, CYS134E, CYS140F, CYS211E, CYS216F, CYS88E, CYS92F, GLN126E, GLN167E, GLN171F, GLN37E, GLN38E, GLN39F, GLN42E, GLN46F, GLN89E, GLU123E, GLU124E, GLU160E, GLU210E, GLY100E, GLY101E, GLY102F, GLY104F, GLY106F, GLY139F, GLY158E, GLY174F, GLY41E, GLY42F, GLY44F, GLY97F, GLY99E, HIS164F, HIS34E, HIS35F, HIS95E, ILE136E, ILE48E, LEU117E, LEU124F, LEU125E, LEU132E, LEU135E, LEU138F, LEU141F, LEU170F, LEU175F, LEU178E, LEU178F, LEU180E, LEU45F, LEU46E, LEU4F, LEU50F, LYS105F, LYS129E, LYS143F, LYS163E, LYS166E, LYS171E, LYS209F, LYS210F, LYS214F, LYS31E, LYS43F, LYS64F, LYS94F, LYS96F, MET100F, PHE100F, PHE118E, PHE122F, PHE139E, PHE166F, PHE89F, PHE91F, PHE98E, PRO119E, PRO120E, PRO123F, PRO126F, PRO164E, PRO167F, PRO213F, PRO40E, PRO41F, PRO44E, PRO55E, SER100F, SER114E, SER120F, SER121E, SER122E, SER127F, SER128F, SER137E, SER165E, SER168E, SER172F, SER173F, SER175E, SER176E, SER177F, SER179E, SER179F, SER180F, SER215F, SER49F, SER56E, SER62F, SER93E, SER95E, SER99F, THR116E, THR131E, THR161E, THR162E, THR165F, THR183F, THR209E, THR57F, TRP103F, TRP35E, TRP36F, TRP47F, TRP91E, TYR100F, TYR172E, TYR177E, TYR36E, TYR49E, TYR50E, TYR58F, TYR59F, TYR86E, TYR87E, VAL115E, VAL121F, VAL133E, VAL142F, VAL159E, VAL163F, VAL169F, VAL181F, VAL182F, VAL206E, VAL207F, VAL211F, VAL33E, VAL37F, VAL45E, VAL47E, VAL48F, VAL63F, VAL90E, VAL96E, VAL97E
• F-L: ALA158L, ALA24F, ASN155L, ASN73F, ASN76F, ASP208L, ASP30F, ASP31F, ASP72F, GLN192L, GLN3F, GLU1F, GLU212L, GLY190L, GLY26F, ILE195L, LEU159L, LEU189L, LYS210L, LYS75F, PHE27F, PHE29F, SER187L, SER188L, SER25F, SER28F, SER74F, SER77F, THR191L, THR193L, THR23F, TYR194L, VAL2F
• G-H: ALA125H, ALA127G, ALA130G, ALA136H, ALA137H, ALA168H, ALA173G, ALA174G, ALA40H, ALA43G, ALA60H, ALA93H, ARG38H, ARG54G, ARG56H, ASN169G, ASN30G, ASN32G, ASP100H, ASP101H, ASP138G, ASP144H, ASP53G, ASP61H, ASP85G, ASP92G, ASP95G, ASP95H, ASP98H, CYS134G, CYS140H, CYS211G, CYS216H, CYS88G, CYS92H, GLN126G, GLN167G, GLN171H, GLN37G, GLN38G, GLN39H, GLN42G, GLN46H, GLN89G, GLU123G, GLU124G, GLU160G, GLU210G, GLY100G, GLY101G, GLY102H, GLY104H, GLY106H, GLY139H, GLY158G, GLY162H, GLY41G, GLY42H, GLY44H, GLY97H, GLY99G, HIS164H, HIS34G, HIS35H, HIS95G, ILE136G, ILE48G, LEU117G, LEU124H, LEU125G, LEU132G, LEU135G, LEU138H, LEU141H, LEU170H, LEU175H, LEU178G, LEU178H, LEU180G, LEU45H, LEU46G, LEU4H, LEU50H, LYS105H, LYS129G, LYS143H, LYS163G, LYS166G, LYS171G, LYS209H, LYS214H, LYS31G, LYS43H, LYS64H, LYS94H, LYS96H, MET100H, PHE100H, PHE118G, PHE122H, PHE139G, PHE166H, PHE89H, PHE91H, PHE98G, PRO119G, PRO120G, PRO123H, PRO126H, PRO164G, PRO167H, PRO40G, PRO41H, PRO44G, PRO55G, SER100H, SER114G, SER120H, SER121G, SER122G, SER127H, SER128H, SER137G, SER161H, SER165G, SER168G, SER172H, SER173H, SER175G, SER176G, SER177H, SER179G, SER179H, SER180H, SER215H, SER49H, SER56G, SER62H, SER93G, SER95G, SER99H, THR116G, THR131G, THR135H, THR160H, THR161G, THR162G, THR165H, THR183H, THR57H, TRP103H, TRP35G, TRP36H, TRP47H, TRP91G, TYR100H, TYR172G, TYR177G, TYR36G, TYR49G, TYR50G, TYR58H, TYR59H, TYR86G, TYR87G, VAL115G, VAL121H, VAL133G, VAL142H, VAL159G, VAL163H, VAL169H, VAL181H, VAL182H, VAL206G, VAL211H, VAL33G, VAL37H, VAL45G, VAL47G, VAL48H, VAL63H, VAL90G, VAL96G, VAL97G
• G-I: ALA127G, ALA127I, ASN128G, ASN128I, LYS129G, LYS129I
• G-J: ALA114J, ALA127G, ASN128G, ASP144J, GLN126G, GLU123G, GLU124G, GLY118J, GLY174J, HIS200J, LEU125G, LEU175J, LYS117J, PHE146J, PRO119J, SER112J, SER113J, SER115J, SER120J, SER121G, SER122G, SER173J, SER203J, THR116J, THR205J, TYR145J
• H-I: ALA114H, ALA127I, ASN128I, ASP144H, GLN126I, GLU123I, GLU124I, GLY118H, GLY174H, HIS200H, LEU125I, LEU175H, LYS117H, LYS129I, PHE146H, PRO119H, SER112H, SER113H, SER115H, SER120H, SER121I, SER122I, SER173H, SER203H, THR116H, THR205H, TYR145H
• H-J: ASN197H, ASN197J, ASN204H, ASN204J, ASP208H, ASP208J, CYS196H, CYS196J, GLU212H, GLU212J, GLY118H, GLY118J, HIS200H, HIS200J, ILE195H, ILE195J, LYS117H, LYS117J, LYS201H, LYS201J, LYS206H, LYS206J, LYS209H, LYS209J, LYS210H, LYS210J, PHE122H, PHE122J, PRO119H, PRO119J, PRO123H, PRO123J, PRO202H, PRO202J, SER120H, SER120J, SER203H, SER203J, THR116H, THR116J, THR193H, THR193J, THR205H, THR205J, TYR194H, TYR194J, VAL121H, VAL121J, VAL198H, VAL198J, VAL207H, VAL207J, VAL211H, VAL211J
• I-J: ALA125J, ALA127I, ALA130I, ALA136J, ALA137J, ALA168J, ALA173I, ALA174I, ALA207I, ALA40J, ALA43I, ALA60J, ALA93J, ARG38J, ARG54I, ARG56J, ASN169I, ASN32I, ASP100J, ASP101J, ASP138I, ASP144J, ASP51I, ASP53I, ASP61J, ASP85I, ASP92I, ASP95I, ASP95J, ASP98J, CYS134I, CYS140J, CYS211I, CYS216J, CYS88I, CYS92J, GLN126I, GLN167I, GLN171J, GLN37I, GLN38I, GLN39J, GLN42I, GLN46J, GLN89I, GLU123I, GLU124I, GLU160I, GLU210I, GLY100I, GLY101I, GLY102J, GLY104J, GLY106J, GLY139J, GLY158I, GLY162J, GLY41I, GLY42J, GLY44J, GLY97J, GLY99I, HIS164J, HIS34I, HIS35J, HIS95I, ILE136I, ILE48I, LEU117I, LEU124J, LEU125I, LEU132I, LEU135I, LEU138J, LEU141J, LEU170J, LEU175J, LEU178I, LEU178J, LEU180I, LEU45J, LEU46I, LEU4J, LEU50J, LYS105J, LYS129I, LYS143J, LYS163I, LYS166I, LYS171I, LYS209J, LYS210J, LYS214J, LYS43J, LYS64J, LYS94J, LYS96J, MET100J, PHE100J, PHE118I, PHE122J, PHE139I, PHE166J, PHE89J, PHE91J, PHE98I, PRO119I, PRO120I, PRO123J, PRO126J, PRO164I, PRO167J, PRO208I, PRO40I, PRO41J, PRO44I, PRO55I, SER100J, SER114I, SER120J, SER121I, SER122I, SER127J, SER128J, SER137I, SER161J, SER165I, SER168I, SER172J, SER173J, SER175I, SER176I, SER177J, SER179I, SER179J, SER180J, SER215J, SER49J, SER56I, SER62J, SER93I, SER95I, SER99J, THR116I, THR131I, THR160J, THR161I, THR162I, THR165J, THR183J, THR209I, THR57J, TRP103J, TRP185I, TRP35I, TRP36J, TRP47J, TRP91I, TYR100J, TYR172I, TYR177I, TYR36I, TYR49I, TYR50I, TYR58J, TYR59J, TYR86I, TYR87I, VAL115I, VAL121J, VAL133I, VAL142J, VAL159I, VAL163J, VAL169J, VAL181J, VAL182J, VAL206I, VAL211J, VAL33I, VAL37J, VAL45I, VAL47I, VAL48J, VAL63J, VAL90I, VAL96I, VAL97I
• K-L: ALA125L, ALA127K, ALA130K, ALA136L, ALA137L, ALA157K, ALA168L, ALA173K, ALA174K, ALA43K, ALA60L, ALA93L, ARG38L, ARG54K, ARG56L, ASN128K, ASN169K, ASN30K, ASN32K, ASP100L, ASP101L, ASP138K, ASP144L, ASP51K, ASP53K, ASP61L, ASP85K, ASP92K, ASP95K, ASP95L, ASP98L, CYS134K, CYS140L, CYS211K, CYS216L, CYS88K, CYS92L, GLN126K, GLN167K, GLN171L, GLN37K, GLN38K, GLN39L, GLN42K, GLN46L, GLN89K, GLU123K, GLU124K, GLU160K, GLU210K, GLY100K, GLY101K, GLY102L, GLY104L, GLY106L, GLY139L, GLY158K, GLY162L, GLY174L, GLY41K, GLY42L, GLY44L, GLY97L, GLY99K, HIS164L, HIS34K, HIS35L, HIS95K, ILE136K, ILE48K, LEU117K, LEU124L, LEU125K, LEU132K, LEU135K, LEU138L, LEU141L, LEU170L, LEU175L, LEU178K, LEU178L, LEU180K, LEU45L, LEU46K, LEU4L, LEU50L, LYS105L, LYS117L, LYS129K, LYS143L, LYS163K, LYS166K, LYS209L, LYS210L, LYS214L, LYS31K, LYS43L, LYS64L, LYS94L, LYS96L, MET100L, PHE100L, PHE118K, PHE122L, PHE139K, PHE166L, PHE89L, PHE91L, PHE98K, PRO119K, PRO120K, PRO123L, PRO126L, PRO164K, PRO167L, PRO208K, PRO40K, PRO41L, PRO44K, PRO55K, SER100L, SER114K, SER120L, SER121K, SER122K, SER127L, SER137K, SER161L, SER165K, SER168K, SER172L, SER173L, SER175K, SER176K, SER177L, SER179K, SER179L, SER180L, SER215L, SER49L, SER56K, SER62L, SER93K, SER95K, SER99L, THR116K, THR131K, THR160L, THR161K, THR162K, THR165L, THR183L, THR57L, TRP103L, TRP185K, TRP35K, TRP36L, TRP47L, TRP91K, TYR100L, TYR172K, TYR176L, TYR177K, TYR36K, TYR49K, TYR50K, TYR58L, TYR59L, TYR86K, TYR87K, VAL121L, VAL133K, VAL142L, VAL159K, VAL163L, VAL169L, VAL181L, VAL182L, VAL206K, VAL211L, VAL33K, VAL37L, VAL45K, VAL47K, VAL48L, VAL63L, VAL90K, VAL96K, VAL97K