3PVO

monoclinic form of human c-reactive protein

• Total interactions analyzed: 190
• Total true interactions: 23
• Strongest Interaction:
  • Chains: I-J
  • Int. Res.: 71
  • Norm. En. per Res.: -4.8951
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-45.988	-122.8335	-163.132	-331.9535	68	10	3	7166	10	25	17
A-E	-40.7841	-103.2461	-180.007	-324.0372	70	8	3	7306	8	26	18
A-P	0.0	-26.5863	-12.9684	-39.5547	23	1	0	820	1	3	5
B-C	-29.0447	-84.1329	-149.429	-262.6066	69	11	3	7287	7	25	16
C-D	-40.0781	-110.4645	-172.352	-322.8946	71	10	3	7355	8	26	18
D-E	-38.4525	-115.7683	-176.975	-331.1958	70	7	3	7337	10	25	17
E-T	0.0	-3.3727	-7.4986	-10.8712	12	1	0	409	0	5	5
F-G	-39.7006	-117.3986	-137.014	-294.1132	70	10	3	7476	8	26	17
F-J	-38.438	-108.9043	-171.856	-319.1983	69	9	3	7309	9	25	18
G-H	-51.5654	-122.498	-157.315	-331.3784	70	14	3	7336	9	27	17
G-T	0.0	0.0	-0.0072	-0.0072	3	0	0	8	0	4	11
H-I	-31.0136	-90.5866	-164.4	-286.0002	67	5	3	6941	6	26	17
I-J	-51.3578	-114.0354	-182.16	-347.5532	71	7	3	7385	8	27	16
K-L	-50.7723	-110.557	-165.852	-327.1813	71	12	3	7377	9	26	17
K-O	-31.742	-110.2201	-176.511	-318.4731	72	8	3	7370	8	27	18
L-M	-48.9384	-84.4165	-161.652	-295.0069	71	10	3	7161	8	26	17
M-N	-46.6071	-103.6582	-173.23	-323.4953	68	8	3	7255	8	26	18
N-O	-24.7655	-112.3544	-183.999	-321.1189	74	10	3	7481	8	26	17
P-Q	-45.9259	-109.0118	-162.058	-316.9957	71	11	3	7298	8	25	17
P-T	-49.5641	-105.8031	-181.674	-337.0411	70	10	3	7502	8	27	18
Q-R	-26.5971	-92.6944	-163.172	-282.4635	72	9	3	7374	7	26	17
R-S	-37.3516	-104.8288	-176.872	-319.0524	69	8	3	7233	8	26	18
S-T	-51.2435	-112.578	-181.863	-345.6845	72	9	3	7445	8	26	18

Interface residues

• A-B: ALA103B, ALA8A, ALA92A, ARG116B, ARG118B, ARG6A, ASN172B, ASP155A, ASP169B, GLN203A, GLU101B, GLU108B, GLU14A, GLU170B, GLU197A, GLU42A, GLU85B, GLY105B, GLY113B, GLY154A, GLY196A, ILE106B, ILE156A, ILE171B, LEU121B, LEU166B, LEU204A, LEU43A, LEU83B, LYS114B, LYS119B, LYS123B, LYS13A, LYS201A, LYS7A, PHE109B, PHE11A, PHE199A, PHE39A, PHE84B, PHE9A, PRO115B, PRO12A, PRO168B, PRO202A, PRO206A, PRO87B, PRO93A, SER104B, SER120B, SER167B, SER44A, SER45A, SER99B, THR200A, THR41A, THR46A, TRP110B, TRP205A, TYR40A, VAL107B, VAL10A, VAL117B, VAL153A, VAL165B, VAL198A, VAL86B, VAL91A
• A-E: ALA103A, ALA8E, ALA92E, ARG116A, ARG118A, ARG6E, ASN172A, ASP155E, ASP169A, GLN203E, GLU101A, GLU108A, GLU14E, GLU170A, GLU197E, GLU42E, GLU85A, GLY105A, GLY154E, GLY196E, ILE106A, ILE156E, ILE171A, ILE82A, LEU121A, LEU152E, LEU166A, LEU204E, LEU43E, LEU83A, LYS114A, LYS119A, LYS122A, LYS123A, LYS13E, LYS201E, LYS7E, PHE109A, PHE11E, PHE199E, PHE39E, PHE84A, PHE9E, PRO115A, PRO12E, PRO168A, PRO202E, PRO206E, PRO87A, PRO93E, SER102A, SER104A, SER120A, SER167A, SER44E, SER45E, THR200E, THR41E, THR46E, TRP110A, TRP205E, TYR40E, VAL107A, VAL10E, VAL117A, VAL153E, VAL165A, VAL198E, VAL86A, VAL91E
• A-P: ALA189A, ALA189P, ARG188A, ARG188P, ARG6A, ASN183P, ASN186P, ASP163P, ASP3A, GLN1A, GLU170P, GLY178A, LYS191A, LYS28P, LYS31P, MET4A, PHE164P, PHE180P, PRO179A, PRO182P, SER181A, SER181P, SER5A
• B-C: ALA103C, ALA8B, ALA92B, ARG116C, ARG118C, ARG6B, ASN172C, ASP155B, ASP169C, GLN203B, GLU101C, GLU108C, GLU14B, GLU170C, GLU197B, GLU42B, GLU85C, GLU88C, GLY105C, GLY113C, GLY154B, GLY196B, ILE106C, ILE156B, ILE171C, ILE82C, LEU121C, LEU166C, LEU204B, LEU43B, LEU83C, LYS114C, LYS119C, LYS122C, LYS123C, LYS13B, LYS201B, LYS7B, PHE109C, PHE11B, PHE199B, PHE84C, PHE9B, PRO115C, PRO12B, PRO168C, PRO202B, PRO206B, PRO87C, PRO93B, SER102C, SER104C, SER120C, SER167C, SER44B, THR200B, THR41B, TRP110C, TRP205B, TYR40B, VAL107C, VAL10B, VAL111C, VAL117C, VAL153B, VAL165C, VAL198B, VAL86C, VAL91B
• C-D: ALA103D, ALA8C, ALA92C, ARG116D, ARG118D, ARG6C, ASN172D, ASP155C, ASP169D, GLN203C, GLU101D, GLU108D, GLU14C, GLU170D, GLU197C, GLU42C, GLU85D, GLU88D, GLY105D, GLY154C, GLY196C, ILE106D, ILE156C, ILE171D, ILE82D, LEU121D, LEU152C, LEU166D, LEU204C, LEU43C, LEU83D, LYS114D, LYS119D, LYS123D, LYS13C, LYS201C, LYS7C, PHE109D, PHE11C, PHE199C, PHE39C, PHE84D, PHE9C, PRO115D, PRO12C, PRO168D, PRO202C, PRO206C, PRO87D, PRO93C, SER102D, SER104D, SER120D, SER167D, SER18C, SER45C, THR200C, THR41C, THR46C, TRP110D, TRP205C, TYR40C, VAL107D, VAL10C, VAL111D, VAL117D, VAL153C, VAL165D, VAL198C, VAL86D, VAL91C
• D-E: ALA103E, ALA8D, ALA92D, ARG116E, ARG118E, ARG6D, ASN172E, ASP155D, ASP169E, GLN203D, GLU101E, GLU108E, GLU14D, GLU170E, GLU197D, GLU42D, GLU85E, GLU88E, GLY105E, GLY113E, GLY154D, GLY196D, ILE106E, ILE156D, ILE171E, ILE82E, LEU121E, LEU166E, LEU204D, LEU43D, LEU83E, LYS114E, LYS119E, LYS123E, LYS13D, LYS201D, LYS7D, PHE109E, PHE11D, PHE199D, PHE39D, PHE84E, PHE9D, PRO115E, PRO12D, PRO168E, PRO202D, PRO206D, PRO87E, PRO93D, SER102E, SER104E, SER120E, SER167E, SER44D, THR200D, THR41D, THR46D, TRP110E, TRP205D, TYR40D, VAL107E, VAL10D, VAL117E, VAL153D, VAL165E, VAL198D, VAL86E, VAL89D, VAL91D
• E-T: ALA189E, ARG188E, ASP3E, ASP3T, GLN1E, GLN1T, LYS191T, LYS7E, MET4E, SER5E, THR2E, THR2T
• F-G: ALA103G, ALA8F, ALA92F, ARG116G, ARG118G, ARG6F, ASP155F, ASP169G, GLN203F, GLU101G, GLU108G, GLU14F, GLU170G, GLU197F, GLU42F, GLU85G, GLY105G, GLY154F, GLY196F, ILE106G, ILE156F, ILE171G, ILE82G, LEU121G, LEU152F, LEU166G, LEU204F, LEU43F, LEU83G, LYS114G, LYS119G, LYS122G, LYS123G, LYS13F, LYS201F, LYS7F, PHE109G, PHE11F, PHE199F, PHE39F, PHE84G, PHE9F, PRO115G, PRO12F, PRO168G, PRO202F, PRO206F, PRO87G, PRO93F, SER102G, SER104G, SER120G, SER167G, SER44F, SER45F, THR200F, THR41F, THR46F, TRP110G, TRP205F, TYR40F, VAL107G, VAL10F, VAL117G, VAL153F, VAL165G, VAL198F, VAL86G, VAL89F, VAL91F
• F-J: ALA103F, ALA8J, ALA92J, ARG116F, ARG118F, ARG6J, ASN172F, ASP155J, ASP169F, GLN203J, GLU101F, GLU108F, GLU14J, GLU170F, GLU197J, GLU42J, GLU85F, GLU88F, GLY105F, GLY154J, GLY196J, ILE106F, ILE156J, ILE171F, ILE82F, LEU121F, LEU152J, LEU166F, LEU204J, LEU43J, LEU83F, LYS114F, LYS119F, LYS122F, LYS123F, LYS13J, LYS201J, LYS7J, PHE109F, PHE11J, PHE199J, PHE39J, PHE84F, PHE9J, PRO115F, PRO12J, PRO168F, PRO202J, PRO206J, PRO87F, PRO93J, SER104F, SER120F, SER167F, SER44J, THR200J, THR41J, THR46J, TRP110F, TRP205J, TYR40J, VAL107F, VAL10J, VAL117F, VAL153J, VAL165F, VAL198J, VAL86F, VAL91J
• G-H: ALA103H, ALA8G, ALA92G, ARG116H, ARG118H, ARG6G, ASN172H, ASP155G, ASP169H, GLN203G, GLU101H, GLU108H, GLU14G, GLU170H, GLU197G, GLU42G, GLU85H, GLY105H, GLY113H, GLY154G, GLY196G, ILE106H, ILE156G, ILE171H, ILE82H, LEU121H, LEU152G, LEU166H, LEU204G, LEU43G, LEU83H, LYS114H, LYS119H, LYS123H, LYS13G, LYS201G, LYS7G, PHE109H, PHE11G, PHE199G, PHE84H, PHE9G, PRO115H, PRO12G, PRO168H, PRO202G, PRO206G, PRO87H, PRO93G, SER102H, SER104H, SER120H, SER167H, SER44G, SER45G, SER99H, THR200G, THR41G, THR46G, TRP110H, TRP205G, TYR40G, VAL107H, VAL10G, VAL117H, VAL153G, VAL165H, VAL198G, VAL86H, VAL91G
• G-T: ARG58G, ASP70T, LYS69T
• H-I: ALA103I, ALA8H, ALA92H, ARG116I, ARG118I, ARG6H, ASN172I, ASP155H, ASP169I, GLN203H, GLU101I, GLU108I, GLU14H, GLU170I, GLU197H, GLU42H, GLU85I, GLY105I, GLY154H, GLY196H, ILE106I, ILE156H, ILE171I, ILE82I, LEU121I, LEU152H, LEU166I, LEU204H, LEU43H, LEU83I, LYS114I, LYS119I, LYS123I, LYS13H, LYS201H, LYS7H, PHE109I, PHE11H, PHE199H, PHE84I, PHE9H, PRO115I, PRO12H, PRO168I, PRO202H, PRO206H, PRO87I, PRO93H, SER102I, SER104I, SER120I, SER167I, SER45H, THR200H, THR41H, THR46H, TRP110I, TRP205H, TYR40H, VAL107I, VAL10H, VAL117I, VAL153H, VAL165I, VAL198H, VAL86I, VAL91H
• I-J: ALA103J, ALA8I, ALA92I, ARG116J, ARG118J, ARG6I, ASN172J, ASP155I, ASP169J, GLN203I, GLU101J, GLU108J, GLU14I, GLU170J, GLU197I, GLU42I, GLU85J, GLU88J, GLY105J, GLY113J, GLY154I, GLY196I, ILE106J, ILE156I, ILE171J, ILE82J, LEU121J, LEU166J, LEU204I, LEU43I, LEU83J, LYS114J, LYS119J, LYS123J, LYS13I, LYS201I, LYS7I, PHE109J, PHE11I, PHE199I, PHE39I, PHE84J, PHE9I, PRO115J, PRO12I, PRO168J, PRO202I, PRO206I, PRO87J, PRO93I, SER102J, SER104J, SER120J, SER167J, SER44I, SER45I, THR200I, THR41I, THR46I, TRP110J, TRP205I, TYR40I, VAL107J, VAL10I, VAL111J, VAL117J, VAL153I, VAL165J, VAL198I, VAL86J, VAL91I
• K-L: ALA103L, ALA8K, ALA92K, ARG116L, ARG118L, ARG6K, ASN172L, ASP155K, ASP169L, GLN203K, GLU101L, GLU108L, GLU14K, GLU170L, GLU197K, GLU42K, GLU85L, GLY105L, GLY113L, GLY154K, GLY196K, ILE106L, ILE156K, ILE171L, ILE82L, LEU121L, LEU152K, LEU166L, LEU204K, LEU43K, LEU83L, LYS114L, LYS119L, LYS122L, LYS123L, LYS13K, LYS201K, LYS7K, PHE109L, PHE11K, PHE199K, PHE39K, PHE84L, PHE9K, PRO115L, PRO12K, PRO168L, PRO202K, PRO206K, PRO87L, PRO93K, SER102L, SER104L, SER120L, SER167L, SER44K, SER45K, THR200K, THR41K, THR90K, TRP110L, TRP205K, TYR40K, VAL107L, VAL10K, VAL117L, VAL153K, VAL165L, VAL198K, VAL86L, VAL91K
• K-O: ALA103K, ALA8O, ALA92O, ARG116K, ARG118K, ARG6O, ASN172K, ASP155O, ASP169K, GLN203O, GLU101K, GLU108K, GLU14O, GLU170K, GLU197O, GLU42O, GLU85K, GLU88K, GLY105K, GLY113K, GLY154O, GLY196O, ILE106K, ILE156O, ILE171K, ILE82K, LEU121K, LEU152O, LEU166K, LEU204O, LEU43O, LEU83K, LYS114K, LYS119K, LYS123K, LYS13O, LYS201O, LYS7O, PHE109K, PHE11O, PHE199O, PHE39O, PHE84K, PHE9O, PRO115K, PRO12O, PRO168K, PRO202O, PRO206O, PRO87K, PRO93O, SER102K, SER104K, SER120K, SER167K, SER44O, SER45O, SER99K, THR200O, THR41O, THR46O, TRP110K, TRP205O, TYR40O, VAL107K, VAL10O, VAL117K, VAL153O, VAL165K, VAL198O, VAL86K, VAL91O
• L-M: ALA103M, ALA8L, ALA92L, ARG116M, ARG118M, ARG6L, ASN172M, ASP155L, ASP169M, GLN203L, GLU101M, GLU108M, GLU14L, GLU170M, GLU197L, GLU42L, GLU85M, GLU88M, GLY105M, GLY113M, GLY154L, GLY196L, ILE106M, ILE156L, ILE171M, ILE82M, LEU121M, LEU152L, LEU166M, LEU204L, LEU43L, LEU83M, LYS114M, LYS119M, LYS122M, LYS123M, LYS13L, LYS201L, LYS7L, PHE109M, PHE11L, PHE199L, PHE84M, PHE9L, PRO115M, PRO12L, PRO168M, PRO202L, PRO206L, PRO87M, PRO93L, SER102M, SER104M, SER120M, SER167M, SER44L, THR200L, THR41L, TRP110M, TRP205L, TYR40L, VAL107M, VAL10L, VAL111M, VAL117M, VAL153L, VAL165M, VAL198L, VAL86M, VAL89L, VAL91L
• M-N: ALA103N, ALA8M, ALA92M, ARG116N, ARG118N, ARG6M, ASN172N, ASP155M, ASP169N, GLN203M, GLU101N, GLU108N, GLU14M, GLU197M, GLU42M, GLU85N, GLY105N, GLY154M, GLY196M, ILE106N, ILE156M, ILE171N, ILE82N, LEU121N, LEU152M, LEU166N, LEU204M, LEU43M, LEU83N, LYS114N, LYS119N, LYS122N, LYS123N, LYS13M, LYS201M, LYS7M, PHE109N, PHE11M, PHE199M, PHE84N, PHE9M, PRO115N, PRO12M, PRO168N, PRO202M, PRO206M, PRO87N, PRO93M, SER102N, SER104N, SER120N, SER167N, SER45M, THR200M, THR41M, THR46M, TRP110N, TRP205M, TYR40M, VAL107N, VAL10M, VAL111N, VAL117N, VAL153M, VAL165N, VAL198M, VAL86N, VAL91M
• N-O: ALA103O, ALA32O, ALA8N, ALA92N, ARG116O, ARG118O, ARG6N, ASN172O, ASP155N, ASP169O, GLN203N, GLU101O, GLU108O, GLU14N, GLU170O, GLU197N, GLU42N, GLU85O, GLU88O, GLY105O, GLY113O, GLY154N, GLY196N, ILE106O, ILE156N, ILE171O, ILE82O, LEU121O, LEU152N, LEU166O, LEU204N, LEU43N, LEU83O, LYS114O, LYS119O, LYS122O, LYS123O, LYS13N, LYS201N, LYS7N, PHE109O, PHE11N, PHE199N, PHE39N, PHE84O, PHE9N, PRO115O, PRO12N, PRO168O, PRO202N, PRO206N, PRO87O, PRO93N, SER102O, SER104O, SER120O, SER167O, SER44N, SER99O, THR200N, THR41N, THR46N, TRP110O, TRP205N, TYR40N, VAL107O, VAL10N, VAL117O, VAL153N, VAL165O, VAL198N, VAL86O, VAL89N, VAL91N
• P-Q: ALA103Q, ALA8P, ALA92P, ARG116Q, ARG118Q, ARG6P, ASN172Q, ASP155P, ASP169Q, GLN203P, GLU101Q, GLU108Q, GLU14P, GLU170Q, GLU197P, GLU42P, GLU85Q, GLY105Q, GLY113Q, GLY154P, GLY196P, ILE106Q, ILE156P, ILE171Q, ILE82Q, LEU121Q, LEU166Q, LEU204P, LEU43P, LEU83Q, LYS114Q, LYS119Q, LYS122Q, LYS123Q, LYS13P, LYS201P, LYS7P, PHE109Q, PHE11P, PHE199P, PHE39P, PHE84Q, PHE9P, PRO115Q, PRO12P, PRO168Q, PRO202P, PRO206P, PRO87Q, PRO93P, SER102Q, SER104Q, SER120Q, SER167Q, SER44P, SER45P, SER99Q, THR200P, THR41P, THR46P, TRP110Q, TRP205P, TYR40P, VAL107Q, VAL10P, VAL117Q, VAL153P, VAL165Q, VAL198P, VAL86Q, VAL91P
• P-T: ALA103P, ALA8T, ALA92T, ARG116P, ARG118P, ARG6T, ASN172P, ASP155T, ASP169P, GLN203T, GLU101P, GLU108P, GLU14T, GLU170P, GLU197T, GLU42T, GLU85P, GLY105P, GLY154T, GLY196T, ILE106P, ILE156T, ILE171P, ILE82P, LEU121P, LEU152T, LEU166P, LEU204T, LEU43T, LEU83P, LYS114P, LYS119P, LYS123P, LYS13T, LYS201T, LYS7T, PHE109P, PHE11T, PHE199T, PHE39T, PHE84P, PHE9T, PRO115P, PRO12T, PRO168P, PRO202T, PRO206T, PRO87P, PRO93T, SER102P, SER104P, SER120P, SER167P, SER44T, SER45T, THR200T, THR41T, THR46T, TRP110P, TRP205T, TYR40T, VAL107P, VAL10T, VAL111P, VAL117P, VAL153T, VAL165P, VAL198T, VAL86P, VAL91T
• Q-R: ALA103R, ALA8Q, ALA92Q, ARG116R, ARG118R, ARG6Q, ASN172R, ASP155Q, ASP169R, GLN203Q, GLU101R, GLU108R, GLU14Q, GLU170R, GLU197Q, GLU42Q, GLU85R, GLU88R, GLY105R, GLY113R, GLY154Q, GLY196Q, ILE106R, ILE156Q, ILE171R, ILE82R, LEU121R, LEU152Q, LEU166R, LEU204Q, LEU43Q, LEU83R, LYS114R, LYS119R, LYS122R, LYS123R, LYS13Q, LYS201Q, LYS7Q, PHE109R, PHE11Q, PHE199Q, PHE84R, PHE9Q, PRO115R, PRO12Q, PRO168R, PRO202Q, PRO206Q, PRO87R, PRO93Q, SER102R, SER104R, SER120R, SER167R, SER44Q, SER45Q, THR200Q, THR41Q, THR46Q, TRP110R, TRP205Q, TYR40Q, VAL107R, VAL10Q, VAL117R, VAL153Q, VAL165R, VAL198Q, VAL86R, VAL89Q, VAL91Q
• R-S: ALA103S, ALA8R, ALA92R, ARG116S, ARG118S, ARG6R, ASP155R, ASP169S, GLN203R, GLU101S, GLU108S, GLU14R, GLU170S, GLU197R, GLU42R, GLU85S, GLU88S, GLY105S, GLY154R, GLY196R, ILE106S, ILE156R, ILE171S, ILE82S, LEU121S, LEU152R, LEU166S, LEU204R, LEU43R, LEU83S, LYS114S, LYS119S, LYS122S, LYS123S, LYS13R, LYS201R, LYS7R, PHE109S, PHE11R, PHE199R, PHE84S, PHE9R, PRO115S, PRO12R, PRO168S, PRO202R, PRO206R, PRO87S, PRO93R, SER102S, SER104S, SER120S, SER167S, SER44R, SER45R, THR200R, THR41R, THR46R, TRP110S, TRP205R, TYR40R, VAL107S, VAL10R, VAL117S, VAL153R, VAL165S, VAL198R, VAL86S, VAL91R
• S-T: ALA103T, ALA8S, ALA92S, ARG116T, ARG118T, ARG6S, ASN172T, ASP155S, ASP169T, GLN203S, GLU101T, GLU108T, GLU14S, GLU170T, GLU197S, GLU42S, GLU85T, GLU88T, GLY105T, GLY113T, GLY154S, GLY196S, ILE106T, ILE156S, ILE171T, ILE82T, LEU121T, LEU166T, LEU204S, LEU43S, LEU83T, LYS114T, LYS119T, LYS122T, LYS123T, LYS13S, LYS201S, LYS7S, PHE109T, PHE11S, PHE199S, PHE39S, PHE84T, PHE9S, PRO115T, PRO12S, PRO168T, PRO202S, PRO206S, PRO87T, PRO93S, SER102T, SER104T, SER120T, SER167T, SER44S, THR200S, THR41S, THR46S, TRP110T, TRP205S, TYR40S, VAL107T, VAL10S, VAL111T, VAL117T, VAL153S, VAL165T, VAL198S, VAL86T, VAL89S, VAL91S