3PVN

triclinic form of human c-reactive protein in complex with zinc

• Total interactions analyzed: 190
• Total true interactions: 37
• Strongest Interaction:
  • Chains: D-E
  • Int. Res.: 70
  • Norm. En. per Res.: -5.0631
• Hub Node: B(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-29.8401	-101.3211	-170.605	-301.7662	70	9	3	7316	8	26	17
A-E	-48.0107	-104.5616	-168.876	-321.4483	68	8	3	7116	7	26	16
A-T	-16.138	-65.4496	-117.58	-199.1676	55	3	1	4444	5	14	7
B-C	-37.6096	-105.6824	-170.145	-313.437	67	9	3	6919	7	26	16
B-R	0.0	0.0	-0.0966	-0.0966	2	0	0	32	0	0	1
B-S	-14.607	-62.8828	-106.093	-183.5829	60	2	1	4384	4	14	7
B-T	0.0	43.1105	-65.1505	-22.0401	35	0	1	2690	0	0	4
C-D	-42.0113	-102.1958	-177.298	-321.5051	69	10	3	7354	8	26	17
C-P	-13.0509	-24.4828	-46.1356	-83.6693	39	2	1	1905	2	7	8
C-Q	0.0	-3.3182	-27.0216	-30.3398	37	0	0	1476	0	6	4
D-E	-54.6403	-125.142	-174.632	-354.4143	70	14	3	7050	10	23	16
D-P	0.0	-6.6	-30.3832	-36.9832	39	3	0	1607	1	6	4
E-T	0.0	0.0	-0.0101	-0.0101	2	0	0	10	0	0	1
F-G	-49.9038	-103.8304	-173.912	-327.6462	67	8	3	7079	7	25	17
F-J	-53.043	-107.3865	-179.013	-339.4424	70	10	3	7215	7	26	18
F-M	0.0	0.0	-0.0209	-0.0209	2	0	0	12	0	0	1
G-H	-46.7094	-95.9872	-166.533	-309.2296	67	9	3	7065	7	26	17
G-M	-14.2531	-44.7723	-99.7489	-158.7742	58	4	1	4015	3	14	8
H-I	-42.6235	-99.1154	-166.19	-307.9289	65	8	3	6894	7	26	17
H-K	0.0	0.0	-0.2771	-0.2771	3	0	0	35	0	0	1
H-L	-10.2178	-57.4525	-115.961	-183.6314	58	4	1	4439	4	14	8
H-M	0.0	45.175	-65.8121	-20.6371	35	0	1	2651	0	0	4
I-J	-41.747	-131.6228	-174.065	-347.4348	69	7	3	7142	11	25	17
I-N	0.0	1.4661	-24.5837	-23.1176	31	0	1	1116	1	6	8
I-O	0.0	-2.3134	-31.471	-33.7844	40	0	0	1743	0	6	4
J-N	0.0	1.0277	-25.0031	-23.9754	41	6	0	1652	0	6	4
J-R	0.0	0.0	-0.0121	-0.0121	4	0	0	3	0	2	6
K-L	-17.5115	-116.5298	-177.704	-311.7454	69	5	3	7469	9	25	16
K-O	-33.8328	-106.1025	-171.086	-311.0213	68	12	3	7097	7	25	18
L-M	-41.8166	-87.9582	-172.015	-301.7897	70	9	3	7115	7	26	18
M-N	-48.1255	-98.7285	-171.644	-318.498	65	6	3	6982	6	26	18
N-O	-41.2816	-122.97	-187.591	-351.8425	70	9	3	7732	9	26	17
P-Q	-26.9146	-123.1006	-182.381	-332.3962	69	7	3	7331	9	25	17
P-T	-44.3312	-91.3002	-169.527	-305.1584	66	7	3	7123	7	25	17
Q-R	-37.6163	-101.8542	-179.088	-318.5585	69	9	3	7323	7	27	18
R-S	-36.1286	-112.4098	-161.462	-310.0004	66	8	3	7278	8	26	17
S-T	-46.5914	-107.5185	-176.89	-330.9999	69	12	3	7282	7	28	19

Interface residues

• A-B: ALA103B, ALA8A, ALA92A, ARG116B, ARG118B, ARG6A, ASN172B, ASP155A, ASP169B, GLN203A, GLU101B, GLU108B, GLU14A, GLU170B, GLU197A, GLU42A, GLU85B, GLY105B, GLY154A, GLY196A, ILE106B, ILE156A, ILE171B, ILE82B, LEU121B, LEU152A, LEU166B, LEU204A, LEU43A, LEU83B, LYS114B, LYS119B, LYS122B, LYS123B, LYS13A, LYS201A, LYS7A, PHE109B, PHE11A, PHE199A, PHE39A, PHE84B, PHE9A, PRO115B, PRO12A, PRO168B, PRO202A, PRO206A, PRO87B, PRO93A, SER102B, SER104B, SER120B, SER167B, SER44A, SER45A, THR200A, THR41A, THR46A, TRP110B, TRP205A, TYR40A, VAL107B, VAL10A, VAL117B, VAL153A, VAL165B, VAL198A, VAL86B, VAL91A
• A-E: ALA103A, ALA8E, ALA92E, ARG116A, ARG118A, ARG6E, ASP155E, ASP169A, GLN203E, GLU101A, GLU108A, GLU14E, GLU170A, GLU197E, GLU42E, GLU85A, GLY105A, GLY113A, GLY154E, GLY196E, ILE106A, ILE156E, ILE171A, ILE82A, LEU121A, LEU166A, LEU204E, LEU43E, LEU83A, LYS114A, LYS119A, LYS122A, LYS123A, LYS13E, LYS201E, LYS7E, PHE109A, PHE11E, PHE199E, PHE39E, PHE84A, PHE9E, PRO115A, PRO12E, PRO168A, PRO202E, PRO206E, PRO87A, PRO93E, SER104A, SER120A, SER167A, SER18E, SER44E, THR200E, THR41E, TRP110A, TRP205E, TYR40E, VAL107A, VAL10E, VAL111A, VAL117A, VAL153E, VAL165A, VAL198E, VAL86A, VAL91E
• A-T: ALA189A, ALA189T, ALA24T, ALA32T, ARG188A, ARG188T, ARG6A, ASN172A, ASN183T, ASN186T, ASP163T, ASP169A, ASP3A, ASP3T, GLN1T, GLN203A, GLU170A, GLU170T, GLY177A, GLY178A, GLY178T, HIS38A, ILE174A, LEU166T, LEU176A, LEU185T, LEU190T, LEU26T, LYS191T, LYS23T, LYS28T, MET161T, PHE164T, PHE180A, PHE180T, PRO179A, PRO179T, PRO182T, PRO206A, PRO25T, SER167A, SER167T, SER181A, SER181T, SER5A, THR173A, THR173T, THR27T, THR2T, TRP162T, TRP187T, TRP205A, TYR175A, VAL165T, VAL184T
• B-C: ALA103C, ALA8B, ALA92B, ARG116C, ARG118C, ARG6B, ASP155B, ASP169C, GLN203B, GLU101C, GLU108C, GLU14B, GLU170C, GLU197B, GLU42B, GLU85C, GLU88C, GLY105C, GLY154B, GLY196B, ILE106C, ILE156B, ILE171C, ILE82C, LEU121C, LEU152B, LEU166C, LEU204B, LEU43B, LEU83C, LYS114C, LYS119C, LYS123C, LYS13B, LYS201B, LYS7B, PHE109C, PHE11B, PHE199B, PHE39B, PHE84C, PHE9B, PRO115C, PRO12B, PRO168C, PRO202B, PRO206B, PRO87C, PRO93B, SER104C, SER120C, SER167C, SER44B, THR200B, THR41B, THR46B, TRP110C, TRP205B, TYR40B, VAL107C, VAL10B, VAL117C, VAL153B, VAL165C, VAL198B, VAL89B, VAL91B
• B-R: ARG6R, GLN1B
• B-S: ALA189B, ALA189S, ALA24B, ARG188B, ARG188S, ARG6S, ASN160B, ASN172S, ASN183B, ASN186B, ASN186S, ASP163B, ASP169B, ASP169S, ASP3B, ASP3S, GLN1B, GLN203S, GLU170B, GLU170S, GLY177S, GLY178B, GLY178S, HIS38S, ILE174B, ILE174S, LEU166B, LEU176S, LEU185B, LEU190B, LEU26B, LEU30B, LYS191B, LYS23B, LYS28B, MET161B, MET4B, PHE164B, PHE180B, PHE180S, PRO168S, PRO179B, PRO179S, PRO182B, PRO206S, PRO25B, SER167B, SER167S, SER181B, SER181S, SER5S, THR173B, THR173S, THR27B, THR2B, TRP162B, TRP187B, TRP205S, TYR175S, VAL184B
• B-T: ASN172B, ASN172T, ASP169B, ASP169T, GLU170B, GLU170T, GLY113B, GLY113T, GLY177B, GLY177T, GLY178B, GLY178T, ILE171B, ILE171T, ILE174B, ILE174T, LEU166T, LEU176B, LEU176T, LYS114B, LYS114T, PHE164B, PHE180B, PHE180T, PRO168B, PRO168T, PRO179B, PRO179T, SER167B, SER167T, THR173B, THR173T, TRP110B, TYR175B, TYR175T
• C-D: ALA103D, ALA8C, ALA92C, ARG116D, ARG118D, ARG6C, ASN172D, ASP155C, ASP169D, GLN203C, GLU101D, GLU108D, GLU14C, GLU170D, GLU197C, GLU42C, GLU85D, GLY105D, GLY113D, GLY154C, GLY196C, ILE106D, ILE156C, ILE171D, ILE82D, LEU121D, LEU152C, LEU166D, LEU204C, LEU43C, LEU83D, LYS114D, LYS119D, LYS122D, LYS123D, LYS13C, LYS201C, LYS7C, PHE109D, PHE11C, PHE199C, PHE39C, PHE84D, PHE9C, PRO115D, PRO12C, PRO168D, PRO202C, PRO206C, PRO87D, PRO93C, SER104D, SER120D, SER167D, SER44C, THR200C, THR41C, THR46C, TRP110D, TRP205C, TYR40C, VAL107D, VAL10C, VAL117D, VAL153C, VAL165D, VAL198C, VAL86D, VAL91C
• C-P: ALA189C, ALA189P, ARG188C, ARG188P, ARG6C, ARG6P, ASN172C, ASN172P, ASN186C, ASN186P, ASP3C, ASP3P, GLN203P, GLY177C, GLY177P, GLY178C, GLY178P, LEU176C, LEU176P, LYS7C, LYS7P, MET4C, MET4P, PHE180C, PHE180P, PRO179C, PRO179P, PRO202C, PRO202P, PRO206C, PRO206P, SER5C, SER5P, THR173P, TRP187C, TRP187P, TRP205C, TRP205P, TYR175C
• C-Q: ALA189C, ALA24C, ARG188C, ARG188Q, ARG6Q, ASN172Q, ASN183C, ASN186C, ASP163C, ASP169Q, ASP3C, GLN1C, GLU170Q, GLY177Q, GLY178Q, ILE174Q, LEU176Q, LEU185C, LEU26C, LYS28C, PHE164C, PHE164Q, PHE180C, PHE180Q, PRO168Q, PRO179C, PRO179Q, PRO182C, PRO25C, SER167Q, SER181C, SER181Q, SER5C, THR173Q, THR27C, TYR175Q, VAL184C
• D-E: ALA103E, ALA8D, ALA92D, ARG116E, ARG118E, ARG6D, ASP155D, ASP169E, GLN203D, GLU101E, GLU108E, GLU14D, GLU170E, GLU197D, GLU42D, GLU85E, GLY105E, GLY113E, GLY154D, GLY196D, ILE106E, ILE156D, ILE171E, ILE82E, LEU121E, LEU166E, LEU204D, LEU43D, LEU83E, LYS114E, LYS119E, LYS122E, LYS123E, LYS13D, LYS201D, LYS7D, PHE109E, PHE11D, PHE199D, PHE39D, PHE84E, PHE9D, PRO115E, PRO12D, PRO168E, PRO202D, PRO206D, PRO87E, PRO93D, SER102E, SER104E, SER120E, SER167E, SER44D, SER99E, THR200D, THR41D, THR46D, TRP110E, TRP205D, TYR40D, VAL107E, VAL10D, VAL111E, VAL117E, VAL153D, VAL165E, VAL198D, VAL86E, VAL91D
• D-P: ALA189P, ALA24P, ARG188D, ARG188P, ASN172D, ASN183P, ASN186P, ASP163P, ASP169D, ASP3P, GLN1P, GLU170D, GLY177D, GLY178D, ILE171D, ILE174D, LEU176D, LEU185P, LEU26P, LYS191P, LYS28P, PHE164D, PHE164P, PHE180D, PHE180P, PRO168D, PRO179D, PRO179P, PRO182P, PRO25P, SER167D, SER181D, SER181P, SER5P, THR173D, THR27P, TRP162P, TYR175D, VAL184P
• E-T: ARG6E, GLN1T
• F-G: ALA103G, ALA8F, ALA92F, ARG116G, ARG118G, ARG6F, ASP155F, ASP169G, GLN203F, GLU101G, GLU108G, GLU14F, GLU170G, GLU197F, GLU42F, GLU85G, GLY105G, GLY154F, GLY196F, ILE106G, ILE156F, ILE171G, ILE82G, LEU121G, LEU166G, LEU204F, LEU43F, LEU83G, LYS114G, LYS119G, LYS123G, LYS13F, LYS201F, LYS7F, PHE109G, PHE11F, PHE199F, PHE39F, PHE84G, PHE9F, PRO115G, PRO12F, PRO168G, PRO202F, PRO206F, PRO87G, PRO93F, SER104G, SER120G, SER167G, SER44F, SER45F, THR200F, THR41F, THR46F, TRP110G, TRP205F, TYR40F, VAL107G, VAL10F, VAL111G, VAL117G, VAL153F, VAL165G, VAL198F, VAL86G, VAL91F
• F-J: ALA103F, ALA8J, ALA92J, ARG116F, ARG118F, ARG6J, ASP155J, ASP169F, GLN203J, GLU101F, GLU108F, GLU14J, GLU170F, GLU197J, GLU42J, GLU85F, GLU88F, GLY105F, GLY113F, GLY154J, GLY196J, ILE106F, ILE156J, ILE171F, ILE82F, LEU121F, LEU166F, LEU204J, LEU43J, LEU83F, LYS114F, LYS119F, LYS122F, LYS123F, LYS13J, LYS201J, LYS7J, PHE109F, PHE11J, PHE199J, PHE39J, PHE84F, PHE9J, PRO115F, PRO12J, PRO168F, PRO202J, PRO206J, PRO87F, PRO93J, SER104F, SER120F, SER167F, SER44J, SER45J, THR200J, THR41J, THR46J, TRP110F, TRP205J, TYR40J, VAL107F, VAL10J, VAL117F, VAL153J, VAL165F, VAL198J, VAL86F, VAL89J, VAL91J
• F-M: ARG6F, GLN1M
• G-H: ALA103H, ALA8G, ALA92G, ARG116H, ARG118H, ARG6G, ASN172H, ASP155G, ASP169H, GLN203G, GLU101H, GLU108H, GLU14G, GLU197G, GLU42G, GLU85H, GLY105H, GLY154G, GLY196G, ILE106H, ILE156G, ILE171H, ILE82H, LEU121H, LEU152G, LEU166H, LEU204G, LEU43G, LEU83H, LYS114H, LYS119H, LYS122H, LYS123H, LYS13G, LYS201G, LYS7G, PHE109H, PHE11G, PHE199G, PHE39G, PHE84H, PHE9G, PRO115H, PRO12G, PRO168H, PRO202G, PRO206G, PRO87H, PRO93G, SER104H, SER120H, SER167H, SER45G, THR200G, THR41G, THR46G, TRP110H, TRP205G, TYR40G, VAL107H, VAL10G, VAL117H, VAL153G, VAL165H, VAL198G, VAL86H, VAL91G
• G-M: ALA189G, ALA189M, ALA24M, ARG188G, ARG188M, ARG6G, ASN158G, ASN172G, ASN183M, ASN186G, ASN186M, ASP163M, ASP169G, ASP3G, ASP3M, GLN1M, GLN203G, GLU170G, GLU170M, GLY177G, GLY178G, GLY178M, HIS38G, ILE174G, LEU166M, LEU176G, LEU185M, LEU190M, LEU26M, LEU30M, LYS191M, LYS23M, LYS28M, MET161M, PHE164M, PHE180G, PHE180M, PRO168G, PRO179G, PRO179M, PRO182M, PRO202G, PRO206G, PRO25M, SER167M, SER181G, SER181M, SER5G, THR173G, THR173M, THR27M, THR2M, TRP162M, TRP187M, TRP205G, TYR175G, VAL165M, VAL184M
• H-I: ALA103I, ALA8H, ALA92H, ARG116I, ARG118I, ARG6H, ASP155H, ASP169I, GLN203H, GLU101I, GLU108I, GLU14H, GLU170I, GLU197H, GLU42H, GLU85I, GLY105I, GLY154H, GLY196H, ILE106I, ILE156H, ILE171I, ILE82I, LEU121I, LEU152H, LEU166I, LEU204H, LEU43H, LEU83I, LYS114I, LYS119I, LYS123I, LYS13H, LYS201H, LYS7H, PHE109I, PHE11H, PHE199H, PHE84I, PHE9H, PRO115I, PRO12H, PRO168I, PRO202H, PRO206H, PRO87I, PRO93H, SER104I, SER120I, SER167I, SER45H, THR200H, THR41H, THR46H, TRP110I, TRP205H, TYR40H, VAL107I, VAL10H, VAL117I, VAL153H, VAL165I, VAL198H, VAL86I, VAL91H
• H-K: ARG6K, GLN1H, PRO206K
• H-L: ALA189H, ALA24H, ALA32H, ARG188H, ARG188L, ARG6L, ASN158L, ASN172L, ASN183H, ASN186H, ASP163H, ASP169L, ASP3H, ASP3L, GLN1H, GLN203L, GLU170H, GLU170L, GLY177L, GLY178H, GLY178L, HIS38L, ILE171L, ILE174L, LEU166H, LEU176L, LEU185H, LEU190H, LEU26H, LEU30H, LYS191H, LYS23H, LYS28H, MET161H, PHE164H, PHE180H, PHE180L, PRO168L, PRO179H, PRO179L, PRO182H, PRO206L, PRO25H, SER167H, SER167L, SER181H, SER181L, SER5L, THR173H, THR173L, THR27H, THR2H, TRP162H, TRP187H, TRP205L, TYR175L, VAL165H, VAL184H
• H-M: ASN172H, ASN172M, ASP169H, ASP169M, GLU170H, GLU170M, GLY113H, GLY113M, GLY177H, GLY177M, GLY178H, GLY178M, ILE171H, ILE171M, ILE174H, ILE174M, LEU166M, LEU176H, LEU176M, LYS114H, LYS114M, PHE180H, PHE180M, PRO115M, PRO168H, PRO168M, PRO179H, PRO179M, SER167H, SER167M, THR173H, THR173M, TRP110H, TYR175H, TYR175M
• I-J: ALA103J, ALA8I, ALA92I, ARG116J, ARG118J, ARG6I, ASP155I, ASP169J, GLN203I, GLU101J, GLU108J, GLU14I, GLU170J, GLU197I, GLU42I, GLU85J, GLY105J, GLY113J, GLY154I, GLY196I, ILE106J, ILE156I, ILE171J, ILE82J, LEU121J, LEU166J, LEU204I, LEU43I, LEU83J, LYS114J, LYS119J, LYS122J, LYS123J, LYS13I, LYS201I, LYS7I, PHE109J, PHE11I, PHE199I, PHE39I, PHE84J, PHE9I, PRO115J, PRO12I, PRO168J, PRO202I, PRO206I, PRO87J, PRO93I, SER102J, SER104J, SER120J, SER167J, SER44I, SER99J, THR200I, THR41I, TRP110J, TRP205I, TYR40I, VAL107J, VAL10I, VAL117J, VAL153I, VAL165J, VAL198I, VAL86J, VAL89I, VAL91I
• I-N: ALA189N, ARG188I, ARG188N, ARG6I, ARG6N, ASN172I, ASN172N, ASP3I, ASP3N, GLN203I, GLY177I, GLY177N, GLY178I, GLY178N, LEU176I, LEU176N, LYS7I, MET4N, PHE180I, PHE180N, PRO179I, PRO179N, PRO202I, PRO202N, PRO206I, PRO206N, SER5I, SER5N, TRP187N, TRP205I, TRP205N
• I-O: ALA189I, ALA24I, ARG188I, ARG188O, ASN172O, ASN183I, ASN186I, ASP163I, ASP169O, ASP3I, GLN1I, GLU170O, GLY177O, GLY178O, ILE171O, ILE174O, LEU176O, LEU185I, LEU26I, LYS114O, LYS191I, PHE164I, PHE164O, PHE180I, PHE180O, PRO168O, PRO179I, PRO179O, PRO182I, PRO25I, SER167O, SER181I, SER181O, SER5I, THR173O, THR27I, TRP162I, TRP162O, TYR175O, VAL184I
• J-N: ALA189N, ALA24N, ARG188J, ARG188N, ASN172J, ASN183N, ASN186N, ASP163N, ASP169J, ASP3J, ASP3N, GLN1N, GLU170J, GLY177J, GLY178J, ILE171J, ILE174J, LEU176J, LEU185N, LEU26N, LYS191N, LYS28N, PHE164J, PHE164N, PHE180J, PHE180N, PRO168J, PRO179J, PRO179N, PRO182N, PRO25N, SER167J, SER181J, SER181N, SER5N, THR173J, THR27N, TRP162J, TRP162N, TYR175J, VAL184N
• J-R: ASP16J, GLU147R, GLY79R, LYS13J
• K-L: ALA103L, ALA8K, ALA92K, ARG116L, ARG118L, ARG6K, ASN172L, ASP155K, ASP169L, GLN203K, GLU101L, GLU108L, GLU14K, GLU170L, GLU197K, GLU42K, GLU85L, GLY105L, GLY113L, GLY154K, GLY196K, ILE106L, ILE156K, ILE171L, LEU121L, LEU166L, LEU204K, LEU43K, LEU83L, LYS114L, LYS119L, LYS122L, LYS123L, LYS13K, LYS201K, LYS7K, PHE109L, PHE11K, PHE199K, PHE39K, PHE84L, PHE9K, PRO115L, PRO12K, PRO168L, PRO202K, PRO206K, PRO87L, PRO93K, SER104L, SER120L, SER167L, SER44K, SER45K, THR200K, THR41K, THR90K, TRP110L, TRP205K, TYR40K, VAL107L, VAL10K, VAL117L, VAL153K, VAL165L, VAL198K, VAL86L, VAL89K, VAL91K
• K-O: ALA103K, ALA8O, ALA92O, ARG116K, ARG118K, ARG6O, ASP155O, ASP169K, GLN203O, GLU101K, GLU108K, GLU14O, GLU170K, GLU197O, GLU42O, GLU85K, GLY105K, GLY154O, GLY196O, ILE106K, ILE156O, ILE171K, ILE82K, LEU121K, LEU152O, LEU166K, LEU204O, LEU43O, LEU83K, LYS114K, LYS119K, LYS122K, LYS123K, LYS13O, LYS201O, LYS7O, PHE109K, PHE11O, PHE199O, PHE39O, PHE84K, PHE9O, PRO115K, PRO12O, PRO168K, PRO202O, PRO206O, PRO87K, PRO93O, SER102K, SER104K, SER120K, SER167K, SER44O, SER45O, THR200O, THR41O, THR46O, TRP110K, TRP205O, TYR40O, VAL107K, VAL10O, VAL117K, VAL153O, VAL165K, VAL198O, VAL91O
• L-M: ALA103M, ALA8L, ALA92L, ARG116M, ARG118M, ARG6L, ASN172M, ASP155L, ASP169M, GLN203L, GLU101M, GLU108M, GLU14L, GLU170M, GLU197L, GLU42L, GLU85M, GLU88M, GLY105M, GLY113M, GLY154L, GLY196L, ILE106M, ILE156L, ILE171M, ILE82M, LEU121M, LEU152L, LEU166M, LEU204L, LEU43L, LEU83M, LYS114M, LYS119M, LYS123M, LYS13L, LYS201L, LYS7L, PHE109M, PHE11L, PHE199L, PHE39L, PHE84M, PHE9L, PRO115M, PRO12L, PRO168M, PRO202L, PRO206L, PRO87M, PRO93L, SER104M, SER120M, SER167M, SER44L, SER45L, THR200L, THR41L, THR46L, TRP110M, TRP205L, TYR40L, VAL107M, VAL10L, VAL117M, VAL153L, VAL165M, VAL198L, VAL86M, VAL91L
• M-N: ALA103N, ALA8M, ALA92M, ARG116N, ARG118N, ARG6M, ASP155M, ASP169N, GLN203M, GLU101N, GLU108N, GLU14M, GLU170N, GLU197M, GLU42M, GLU85N, GLY105N, GLY154M, GLY196M, ILE106N, ILE156M, ILE171N, ILE82N, LEU121N, LEU152M, LEU166N, LEU204M, LEU43M, LEU83N, LYS114N, LYS119N, LYS123N, LYS13M, LYS201M, LYS7M, PHE109N, PHE11M, PHE199M, PHE39M, PHE84N, PHE9M, PRO115N, PRO12M, PRO168N, PRO202M, PRO206M, PRO87N, PRO93M, SER104N, SER120N, SER167N, SER45M, THR200M, THR41M, THR46M, TRP110N, TRP205M, TYR40M, VAL107N, VAL10M, VAL117N, VAL153M, VAL165N, VAL198M, VAL91M
• N-O: ALA103O, ALA8N, ALA92N, ARG116O, ARG118O, ARG6N, ASN172O, ASP155N, ASP169O, GLN203N, GLU101O, GLU108O, GLU14N, GLU170O, GLU197N, GLU42N, GLU85O, GLY105O, GLY113O, GLY154N, GLY196N, ILE106O, ILE156N, ILE171O, ILE82O, LEU121O, LEU166O, LEU204N, LEU43N, LEU83O, LYS114O, LYS119O, LYS122O, LYS123O, LYS13N, LYS201N, LYS7N, PHE109O, PHE11N, PHE199N, PHE39N, PHE84O, PHE9N, PRO115O, PRO12N, PRO168O, PRO202N, PRO206N, PRO87O, PRO93N, SER104O, SER120O, SER167O, SER44N, SER45N, THR200N, THR41N, THR46N, TRP110O, TRP205N, TYR40N, VAL107O, VAL10N, VAL117O, VAL153N, VAL165O, VAL198N, VAL86O, VAL89N, VAL91N
• P-Q: ALA103Q, ALA8P, ALA92P, ARG116Q, ARG118Q, ARG6P, ASN172Q, ASP155P, ASP169Q, GLN203P, GLU101Q, GLU108Q, GLU14P, GLU170Q, GLU197P, GLU42P, GLU85Q, GLU88P, GLU88Q, GLY105Q, GLY113Q, GLY154P, ILE106Q, ILE156P, ILE171Q, ILE82Q, LEU121Q, LEU166Q, LEU204P, LEU43P, LEU83Q, LYS114Q, LYS119Q, LYS123Q, LYS13P, LYS201P, LYS7P, PHE109Q, PHE11P, PHE199P, PHE39P, PHE84Q, PHE9P, PRO115Q, PRO12P, PRO168Q, PRO202P, PRO206P, PRO87Q, PRO93P, SER102Q, SER104Q, SER120Q, SER167Q, SER44P, SER45P, THR200P, THR41P, TRP110Q, TRP205P, TYR40P, VAL107Q, VAL10P, VAL117Q, VAL153P, VAL165Q, VAL198P, VAL86Q, VAL91P
• P-T: ALA103P, ALA8T, ALA92T, ARG116P, ARG118P, ARG6T, ASP155T, ASP169P, GLN203T, GLU101P, GLU108P, GLU14T, GLU170P, GLU197T, GLU42T, GLU85P, GLY105P, GLY154T, GLY196T, ILE106P, ILE156T, ILE171P, ILE82P, LEU121P, LEU152T, LEU166P, LEU204T, LEU43T, LEU83P, LYS114P, LYS119P, LYS122P, LYS123P, LYS13T, LYS201T, LYS7T, PHE109P, PHE11T, PHE199T, PHE39T, PHE84P, PHE9T, PRO115P, PRO12T, PRO168P, PRO202T, PRO206T, PRO87P, PRO93T, SER104P, SER120P, SER167P, THR200T, THR41T, THR46T, TRP110P, TRP205T, TYR40T, VAL107P, VAL10T, VAL117P, VAL153T, VAL165P, VAL198T, VAL86P, VAL91T
• Q-R: ALA103R, ALA8Q, ALA92Q, ARG116R, ARG118R, ARG6Q, ASP155Q, ASP169R, GLN203Q, GLU101R, GLU108R, GLU14Q, GLU170R, GLU197Q, GLU42Q, GLU85R, GLU88R, GLY105R, GLY154Q, GLY196Q, ILE106R, ILE156Q, ILE171R, ILE82R, LEU121R, LEU152Q, LEU166R, LEU204Q, LEU43Q, LEU83R, LYS114R, LYS119R, LYS122R, LYS123R, LYS13Q, LYS201Q, LYS7Q, PHE109R, PHE11Q, PHE199Q, PHE39Q, PHE84R, PHE9Q, PRO115R, PRO12Q, PRO168R, PRO202Q, PRO206Q, PRO87R, PRO93Q, SER104R, SER120R, SER167R, SER44Q, SER45Q, THR200Q, THR41Q, THR46Q, TRP110R, TRP205Q, TYR40Q, VAL107R, VAL10Q, VAL117R, VAL153Q, VAL165R, VAL198Q, VAL86R, VAL91Q
• R-S: ALA103S, ALA8R, ALA92R, ARG116S, ARG118S, ARG6R, ASP155R, ASP169S, GLN203R, GLU101S, GLU108S, GLU14R, GLU197R, GLU42R, GLU85S, GLY105S, GLY113S, GLY154R, GLY196R, ILE106S, ILE156R, ILE171S, ILE82S, LEU121S, LEU166S, LEU204R, LEU43R, LEU83S, LYS114S, LYS119S, LYS122S, LYS123S, LYS13R, LYS201R, LYS7R, PHE109S, PHE11R, PHE199R, PHE39R, PHE84S, PHE9R, PRO115S, PRO12R, PRO168S, PRO202R, PRO206R, PRO87S, PRO93R, SER102S, SER104S, SER120S, SER167S, SER44R, THR200R, THR41R, TRP110S, TRP205R, TYR40R, VAL107S, VAL10R, VAL117S, VAL153R, VAL165S, VAL198R, VAL86S, VAL91R
• S-T: ALA103T, ALA8S, ALA92S, ARG116T, ARG118T, ARG6S, ASN172T, ASP155S, ASP169T, GLN203S, GLU101T, GLU108T, GLU14S, GLU197S, GLU42S, GLU85T, GLY105T, GLY154S, ILE106T, ILE156S, ILE171T, ILE82T, LEU121T, LEU152S, LEU166T, LEU204S, LEU43S, LEU83T, LYS114T, LYS119T, LYS122T, LYS123T, LYS13S, LYS201S, LYS7S, PHE109T, PHE11S, PHE199S, PHE39S, PHE84T, PHE9S, PRO115T, PRO12S, PRO168T, PRO202S, PRO206S, PRO87T, PRO93S, SER102T, SER104T, SER120T, SER167T, SER44S, SER45S, THR200S, THR41S, THR46S, TRP110T, TRP205S, TYR40S, VAL107T, VAL10S, VAL117T, VAL153S, VAL165T, VAL198S, VAL86T, VAL89S, VAL91S