3PVA

penicillin v acylase from b. sphaericus

• Total interactions analyzed: 28
• Total true interactions: 12
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 286
  • Norm. En. per Res.: -4.196
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-47.973	-14.9679	-335.954	-398.8949	107	15	11	14400	0	24	3
A-C	0.0	1.0616	-92.9293	-91.8677	48	10	0	3221	0	6	8
A-D	-242.2102	-27.1878	-930.645	-1200.043	286	56	14	36894	2	46	56
B-C	-230.3832	-23.4958	-927.023	-1180.9021	284	52	14	36771	2	46	56
B-D	0.0	1.0255	-89.3617	-88.3362	48	7	0	3104	0	6	8
C-D	-49.4764	-14.6962	-339.726	-403.8986	107	15	11	14515	0	22	2
E-F	-45.1536	-14.389	-338.268	-397.8107	105	15	11	14440	0	22	2
E-G	0.0	1.035	-89.9889	-88.954	48	7	0	3155	0	6	8
E-H	-240.4306	-21.4931	-944.053	-1205.9767	288	64	16	37216	2	46	57
F-G	-232.423	-23.4342	-896.802	-1152.6592	282	48	14	36088	3	47	55
F-H	0.0	1.0396	-93.4145	-92.3748	49	8	0	3225	0	6	8
G-H	-47.1417	-14.7117	-343.101	-404.9544	106	12	11	14501	0	22	3

Interface residues

• A-B: ALA188A, ALA188B, ALA214A, ALA214B, ALA233A, ALA233B, ARG187A, ARG187B, ASN185A, ASN185B, ASN195A, ASN195B, ASP199A, ASP199B, ASP204A, ASP204B, ASP206A, ASP206B, GLN183A, GLN183B, GLN198A, GLN198B, GLU180B, GLY171A, GLY171B, GLY191A, GLY191B, GLY203A, GLY203B, GLY211A, GLY211B, GLY215A, GLY215B, GLY216A, GLY216B, GLY218A, GLY218B, HIS182A, HIS182B, ILE170A, ILE170B, ILE190A, ILE190B, ILE200A, ILE200B, LEU186A, LEU186B, LEU205A, LEU205B, LEU207A, LEU207B, LEU217A, LEU217B, LEU219A, LEU219B, LEU230A, LEU230B, LYS168A, LYS168B, LYS236A, LYS236B, LYS237A, LYS237B, MET201A, MET201B, MET202A, MET202B, PHE210A, PHE210B, PHE229A, PHE229B, PRO194A, PRO194B, PRO196A, PRO196B, PRO197A, PRO197B, PRO209A, PRO209B, PRO220A, PRO220B, THR169A, THR169B, THR184A, THR184B, THR193A, THR193B, THR208A, THR208B, TRP181A, TRP181B, TRP235A, TRP235B, TYR179A, TYR179B, TYR189A, TYR189B, TYR234A, TYR234B, TYR238A, TYR238B, VAL172A, VAL172B, VAL192A, VAL192B, VAL232A, VAL232B
• A-C: ALA188A, ALA188C, ALA227A, ALA227C, ALA84A, ALA84C, ARG187A, ARG187C, ASN185A, ASN185C, ASP222A, ASP222C, GLN183A, GLN183C, GLU180A, GLU180C, GLY178A, GLY178C, GLY218A, GLY218C, HIS182A, HIS182C, LEU186A, LEU186C, LEU230A, LEU230C, PHE86A, PHE86C, PRO177A, PRO177C, PRO220A, PRO220C, PRO225A, PRO225C, SER176A, SER176C, SER226A, SER226C, THR184A, THR184C, THR224A, THR224C, THR85A, THR85C, TRP181A, TRP181C, TYR189A, TYR189C
• A-D: ALA214A, ALA214D, ALA227A, ALA227D, ALA301A, ALA301D, ALA306A, ALA306D, ALA84A, ALA84D, ARG228A, ARG228D, ARG231A, ARG231D, ARG298A, ARG298D, ARG321A, ARG321D, ASN175A, ASN175D, ASN185A, ASN185D, ASN195A, ASN195D, ASN244A, ASN244D, ASN251A, ASN251D, ASN260A, ASN260D, ASN269A, ASN269D, ASN288A, ASN288D, ASN296A, ASN296D, ASN308A, ASN308D, ASN329A, ASN329D, ASN332A, ASN332D, ASP10A, ASP10D, ASP199A, ASP199D, ASP20A, ASP20D, ASP222A, ASP222D, ASP274A, ASP274D, ASP295A, ASP295D, ASP320A, ASP320D, ASP324A, ASP324D, CYS1A, CYS1D, CYS283A, CYS283D, GLN198A, GLN198D, GLN212A, GLN212D, GLN323A, GLN323D, GLN327A, GLN327D, GLN330A, GLN330D, GLU240A, GLU240D, GLU245A, GLU245D, GLU247A, GLU247D, GLU270A, GLU270D, GLU307A, GLU307D, GLU318A, GLU318D, GLY211A, GLY211D, GLY213A, GLY213D, GLY215A, GLY215D, GLY216A, GLY216D, GLY218A, GLY218D, GLY221A, GLY221D, GLY248A, GLY248D, GLY264A, GLY264D, GLY271A, GLY271D, HIS182A, HIS182D, HIS254A, HIS254D, ILE255A, ILE255D, ILE261A, ILE261D, ILE277A, ILE277D, ILE299A, ILE299D, ILE315A, ILE315D, ILE31A, ILE31D, ILE325A, ILE325D, LEU14A, LEU14D, LEU217A, LEU217D, LEU219A, LEU219D, LEU252A, LEU252D, LEU256A, LEU256D, LEU267A, LEU267D, LEU293A, LEU293D, LEU304A, LEU304D, LEU309A, LEU309D, LEU328A, LEU328D, LYS12A, LYS12D, LYS236A, LYS236D, LYS237A, LYS237D, LYS241A, LYS241D, LYS243A, LYS243D, LYS263A, LYS263D, LYS272A, LYS272D, LYS287A, LYS287D, LYS292A, LYS292D, LYS322A, LYS322D, LYS326A, LYS326D, MET305A, MET305D, MET334A, MET334D, MET57A, PHE210A, PHE210D, PHE21A, PHE21D, PHE223A, PHE223D, PHE253A, PHE253D, PHE291A, PHE291D, PHE317A, PHE317D, PHE86A, PHE86D, PRO177A, PRO177D, PRO194A, PRO194D, PRO196A, PRO196D, PRO197A, PRO197D, PRO209A, PRO209D, PRO220A, PRO220D, PRO225A, PRO225D, PRO262A, PRO262D, SER176A, SER176D, SER226A, SER226D, SER257A, SER257D, SER258A, SER258D, SER286A, SER286D, SER297A, SER297D, SER300A, SER300D, SER303A, SER303D, THR174D, THR193A, THR193D, THR208A, THR208D, THR224A, THR224D, THR22A, THR22D, THR239A, THR239D, THR246A, THR246D, THR250A, THR250D, THR268A, THR268D, THR273A, THR273D, THR276A, THR276D, THR279A, THR279D, THR316A, THR316D, THR85A, THR85D, THR8A, THR8D, TRP181A, TRP181D, TRP235A, TRP235D, TRP319A, TRP319D, TYR234A, TYR234D, TYR238A, TYR238D, TYR275A, TYR275D, TYR278A, TYR278D, TYR289A, TYR289D, TYR290A, TYR290D, TYR294A, TYR294D, TYR82A, TYR82D, TYR83A, TYR83D, VAL192A, VAL192D, VAL249A, VAL249D, VAL259A, VAL259D, VAL265A, VAL265D, VAL266A, VAL266D, VAL29A, VAL29D, VAL302A, VAL302D, VAL331A, VAL331D, VAL333A, VAL333D, VAL55A, VAL55D
• B-C: ALA214B, ALA214C, ALA227B, ALA227C, ALA301B, ALA301C, ALA306B, ALA306C, ALA84B, ALA84C, ARG228B, ARG228C, ARG231B, ARG231C, ARG298B, ARG298C, ARG321B, ARG321C, ASN175B, ASN175C, ASN185B, ASN185C, ASN195B, ASN195C, ASN244B, ASN244C, ASN251B, ASN251C, ASN260B, ASN260C, ASN269B, ASN269C, ASN288B, ASN288C, ASN296B, ASN296C, ASN308B, ASN329B, ASN329C, ASN332B, ASN332C, ASP10B, ASP10C, ASP199B, ASP199C, ASP20B, ASP20C, ASP222B, ASP222C, ASP274B, ASP274C, ASP295B, ASP295C, ASP320B, ASP320C, ASP324B, ASP324C, CYS1B, CYS1C, CYS283B, CYS283C, GLN198B, GLN198C, GLN212B, GLN212C, GLN323B, GLN323C, GLN327B, GLN327C, GLN330B, GLN330C, GLU240B, GLU240C, GLU245B, GLU245C, GLU247B, GLU247C, GLU270B, GLU270C, GLU307B, GLU307C, GLU318B, GLU318C, GLY211B, GLY211C, GLY213B, GLY213C, GLY215B, GLY215C, GLY216B, GLY216C, GLY218B, GLY218C, GLY221B, GLY221C, GLY248B, GLY248C, GLY264B, GLY264C, GLY271B, GLY271C, HIS182B, HIS182C, HIS254B, HIS254C, ILE255B, ILE255C, ILE261B, ILE261C, ILE277B, ILE277C, ILE299B, ILE299C, ILE315B, ILE315C, ILE31B, ILE31C, ILE325B, ILE325C, LEU14B, LEU14C, LEU217B, LEU217C, LEU219B, LEU219C, LEU252B, LEU256B, LEU256C, LEU267B, LEU267C, LEU293B, LEU293C, LEU304B, LEU304C, LEU309B, LEU309C, LEU328B, LEU328C, LYS12B, LYS12C, LYS236B, LYS236C, LYS237B, LYS237C, LYS241B, LYS241C, LYS243B, LYS243C, LYS263B, LYS263C, LYS272B, LYS272C, LYS287B, LYS287C, LYS292B, LYS292C, LYS322B, LYS322C, LYS326B, LYS326C, MET305B, MET305C, MET334B, MET334C, MET57C, PHE210B, PHE210C, PHE21B, PHE21C, PHE223B, PHE223C, PHE253B, PHE253C, PHE291B, PHE291C, PHE317B, PHE317C, PHE86B, PHE86C, PRO177B, PRO177C, PRO194B, PRO194C, PRO196B, PRO196C, PRO197B, PRO197C, PRO209B, PRO209C, PRO220B, PRO220C, PRO225B, PRO225C, PRO262B, PRO262C, SER176B, SER176C, SER226B, SER226C, SER257B, SER257C, SER258B, SER258C, SER286B, SER286C, SER297B, SER297C, SER300B, SER300C, SER303B, SER303C, THR174B, THR193B, THR193C, THR208B, THR208C, THR224B, THR224C, THR22B, THR22C, THR239B, THR239C, THR246B, THR246C, THR250B, THR250C, THR268B, THR268C, THR273B, THR273C, THR276B, THR276C, THR279B, THR279C, THR316B, THR316C, THR85B, THR85C, THR8B, THR8C, TRP181B, TRP181C, TRP235B, TRP235C, TRP319B, TRP319C, TYR234B, TYR234C, TYR238B, TYR238C, TYR275B, TYR275C, TYR278B, TYR278C, TYR289B, TYR289C, TYR290B, TYR290C, TYR294B, TYR294C, TYR82B, TYR82C, TYR83B, TYR83C, VAL192B, VAL192C, VAL249B, VAL249C, VAL259B, VAL259C, VAL265B, VAL265C, VAL266B, VAL266C, VAL29B, VAL29C, VAL302B, VAL302C, VAL331B, VAL331C, VAL333B, VAL333C, VAL55B, VAL55C
• B-D: ALA188B, ALA188D, ALA227B, ALA227D, ALA84B, ALA84D, ARG187B, ARG187D, ASN185B, ASN185D, ASP222B, ASP222D, GLN183B, GLN183D, GLU180B, GLU180D, GLY178B, GLY178D, GLY218B, GLY218D, HIS182B, HIS182D, LEU186B, LEU186D, LEU230B, LEU230D, PHE86B, PHE86D, PRO177B, PRO177D, PRO220B, PRO220D, PRO225B, PRO225D, SER176B, SER176D, SER226B, SER226D, THR184B, THR184D, THR224B, THR224D, THR85B, THR85D, TRP181B, TRP181D, TYR189B, TYR189D
• C-D: ALA188C, ALA188D, ALA214C, ALA214D, ALA233C, ALA233D, ARG187C, ARG187D, ASN185C, ASN185D, ASN195C, ASN195D, ASP199C, ASP199D, ASP204C, ASP204D, ASP206C, ASP206D, GLN183C, GLN183D, GLN198C, GLN198D, GLU180C, GLY171C, GLY171D, GLY191C, GLY191D, GLY203C, GLY203D, GLY211C, GLY211D, GLY215C, GLY215D, GLY216C, GLY216D, GLY218C, GLY218D, HIS182C, HIS182D, ILE170C, ILE170D, ILE190C, ILE190D, ILE200C, ILE200D, LEU186C, LEU186D, LEU205C, LEU205D, LEU207C, LEU207D, LEU217C, LEU217D, LEU219C, LEU219D, LEU230C, LEU230D, LYS168C, LYS168D, LYS236C, LYS236D, LYS237C, LYS237D, MET201C, MET201D, MET202C, MET202D, PHE210C, PHE210D, PHE229C, PHE229D, PRO194C, PRO194D, PRO196C, PRO196D, PRO197C, PRO197D, PRO209C, PRO209D, PRO220C, PRO220D, THR169C, THR169D, THR184C, THR184D, THR193C, THR193D, THR208C, THR208D, TRP181C, TRP181D, TRP235C, TRP235D, TYR179C, TYR179D, TYR189C, TYR189D, TYR234C, TYR234D, TYR238C, TYR238D, VAL172C, VAL172D, VAL192C, VAL192D, VAL232C, VAL232D
• E-F: ALA188E, ALA188F, ALA214E, ALA214F, ALA233E, ALA233F, ARG187E, ARG187F, ASN185E, ASN185F, ASN195E, ASN195F, ASP199E, ASP199F, ASP204E, ASP204F, ASP206E, ASP206F, GLN183E, GLN183F, GLN198E, GLN198F, GLY171F, GLY191E, GLY191F, GLY203E, GLY203F, GLY211E, GLY211F, GLY215E, GLY215F, GLY216E, GLY216F, GLY218E, GLY218F, HIS182E, HIS182F, ILE170E, ILE170F, ILE190E, ILE190F, ILE200E, ILE200F, LEU186E, LEU186F, LEU205E, LEU205F, LEU207E, LEU207F, LEU217E, LEU217F, LEU219E, LEU219F, LEU230E, LEU230F, LYS168E, LYS168F, LYS236E, LYS236F, LYS237E, LYS237F, MET201E, MET201F, MET202E, MET202F, PHE210E, PHE210F, PHE229E, PHE229F, PRO194E, PRO194F, PRO196E, PRO196F, PRO197E, PRO197F, PRO209E, PRO209F, PRO220E, PRO220F, THR169E, THR169F, THR184E, THR184F, THR193E, THR193F, THR208E, THR208F, TRP181E, TRP181F, TRP235E, TRP235F, TYR179E, TYR179F, TYR189E, TYR189F, TYR234E, TYR234F, TYR238E, TYR238F, VAL172E, VAL172F, VAL192E, VAL192F, VAL232E, VAL232F
• E-G: ALA188E, ALA188G, ALA227E, ALA227G, ALA84E, ALA84G, ARG187E, ARG187G, ASN185E, ASN185G, ASP222E, ASP222G, GLN183E, GLN183G, GLU180E, GLU180G, GLY178E, GLY178G, GLY218E, GLY218G, HIS182E, HIS182G, LEU186E, LEU186G, LEU230E, LEU230G, PHE86E, PHE86G, PRO177E, PRO177G, PRO220E, PRO220G, PRO225E, PRO225G, SER176E, SER176G, SER226E, SER226G, THR184E, THR184G, THR224E, THR224G, THR85E, THR85G, TRP181E, TRP181G, TYR189E, TYR189G
• E-H: ALA214E, ALA214H, ALA227E, ALA227H, ALA301E, ALA301H, ALA306E, ALA306H, ALA84E, ALA84H, ARG228E, ARG228H, ARG231E, ARG231H, ARG298E, ARG298H, ARG321E, ARG321H, ASN175E, ASN175H, ASN185E, ASN185H, ASN195E, ASN195H, ASN244E, ASN244H, ASN251E, ASN251H, ASN260E, ASN260H, ASN269E, ASN269H, ASN288E, ASN288H, ASN296E, ASN296H, ASN308E, ASN308H, ASN329E, ASN329H, ASN332E, ASN332H, ASP10E, ASP10H, ASP199E, ASP199H, ASP20E, ASP20H, ASP222E, ASP222H, ASP274E, ASP274H, ASP295E, ASP295H, ASP320E, ASP320H, ASP324E, ASP324H, CYS1E, CYS1H, CYS283E, CYS283H, GLN198E, GLN198H, GLN212E, GLN212H, GLN323E, GLN323H, GLN327E, GLN327H, GLN330E, GLN330H, GLU240E, GLU240H, GLU245E, GLU245H, GLU247E, GLU247H, GLU270E, GLU270H, GLU307E, GLU307H, GLU318E, GLU318H, GLY178E, GLY211E, GLY211H, GLY213E, GLY213H, GLY215E, GLY215H, GLY216E, GLY216H, GLY218E, GLY218H, GLY221E, GLY221H, GLY248E, GLY248H, GLY264E, GLY264H, GLY271E, GLY271H, HIS182E, HIS182H, HIS254E, HIS254H, ILE255E, ILE255H, ILE261E, ILE261H, ILE277E, ILE277H, ILE299E, ILE299H, ILE315E, ILE315H, ILE31E, ILE31H, ILE325E, ILE325H, LEU14E, LEU14H, LEU217E, LEU217H, LEU219E, LEU219H, LEU252H, LEU256E, LEU256H, LEU267E, LEU267H, LEU293E, LEU293H, LEU304E, LEU304H, LEU309E, LEU309H, LEU328E, LEU328H, LYS12E, LYS12H, LYS236E, LYS236H, LYS237E, LYS237H, LYS241E, LYS241H, LYS243E, LYS243H, LYS263E, LYS263H, LYS272E, LYS272H, LYS287E, LYS287H, LYS28H, LYS292E, LYS292H, LYS322E, LYS322H, LYS326E, LYS326H, MET305E, MET305H, MET334E, MET334H, MET57E, MET57H, PHE210E, PHE210H, PHE21E, PHE21H, PHE223E, PHE223H, PHE253E, PHE253H, PHE291E, PHE291H, PHE317E, PHE317H, PHE86E, PHE86H, PRO177E, PRO177H, PRO194E, PRO194H, PRO196E, PRO196H, PRO197E, PRO197H, PRO209E, PRO209H, PRO220E, PRO220H, PRO225E, PRO225H, PRO262E, PRO262H, SER176E, SER176H, SER226E, SER226H, SER257E, SER257H, SER258E, SER258H, SER286E, SER286H, SER297E, SER297H, SER300E, SER300H, SER303E, SER303H, THR174H, THR193E, THR193H, THR208E, THR208H, THR224E, THR224H, THR22E, THR22H, THR239E, THR239H, THR246E, THR246H, THR250E, THR250H, THR268E, THR268H, THR273E, THR273H, THR276E, THR276H, THR279E, THR279H, THR316E, THR316H, THR85E, THR85H, THR8E, THR8H, TRP181E, TRP181H, TRP235E, TRP235H, TRP319E, TRP319H, TYR234E, TYR234H, TYR238E, TYR238H, TYR275E, TYR275H, TYR278E, TYR278H, TYR289E, TYR289H, TYR290E, TYR290H, TYR294E, TYR294H, TYR82E, TYR82H, TYR83E, TYR83H, VAL192E, VAL192H, VAL249E, VAL249H, VAL259E, VAL259H, VAL265E, VAL265H, VAL266E, VAL266H, VAL29E, VAL29H, VAL302E, VAL302H, VAL331E, VAL331H, VAL333E, VAL333H, VAL55E, VAL55H
• F-G: ALA214F, ALA214G, ALA227F, ALA227G, ALA301F, ALA301G, ALA306F, ALA306G, ALA84F, ALA84G, ARG228F, ARG228G, ARG231F, ARG231G, ARG298F, ARG298G, ARG321F, ARG321G, ASN175F, ASN175G, ASN185F, ASN185G, ASN195F, ASN195G, ASN244F, ASN244G, ASN251F, ASN251G, ASN260F, ASN260G, ASN269F, ASN269G, ASN288F, ASN288G, ASN296F, ASN296G, ASN329F, ASN329G, ASN332F, ASN332G, ASP10F, ASP10G, ASP199F, ASP199G, ASP20F, ASP20G, ASP222F, ASP222G, ASP274F, ASP274G, ASP295F, ASP295G, ASP320F, ASP320G, ASP324F, ASP324G, CYS1F, CYS1G, CYS283F, CYS283G, GLN198F, GLN198G, GLN212F, GLN212G, GLN323F, GLN323G, GLN327F, GLN327G, GLN330F, GLN330G, GLU240F, GLU240G, GLU245F, GLU245G, GLU247F, GLU247G, GLU270F, GLU270G, GLU307F, GLU307G, GLU318F, GLU318G, GLY211F, GLY211G, GLY213F, GLY213G, GLY215F, GLY215G, GLY216F, GLY216G, GLY218F, GLY218G, GLY221F, GLY221G, GLY248F, GLY248G, GLY264F, GLY264G, GLY271F, GLY271G, HIS182F, HIS182G, HIS254F, HIS254G, ILE255F, ILE255G, ILE261F, ILE261G, ILE277G, ILE299F, ILE299G, ILE315F, ILE315G, ILE31F, ILE31G, ILE325F, ILE325G, LEU14F, LEU14G, LEU217F, LEU217G, LEU219F, LEU219G, LEU230F, LEU252G, LEU256F, LEU256G, LEU267F, LEU267G, LEU293F, LEU293G, LEU304F, LEU304G, LEU328F, LEU328G, LYS12F, LYS12G, LYS236F, LYS236G, LYS237F, LYS237G, LYS241F, LYS241G, LYS243F, LYS243G, LYS263F, LYS263G, LYS272F, LYS272G, LYS287F, LYS287G, LYS292F, LYS292G, LYS322F, LYS322G, LYS326F, LYS326G, MET305F, MET305G, MET334F, MET334G, PHE210F, PHE210G, PHE21F, PHE21G, PHE223F, PHE223G, PHE229F, PHE253F, PHE253G, PHE291F, PHE291G, PHE317F, PHE317G, PHE86F, PHE86G, PRO177F, PRO177G, PRO194F, PRO194G, PRO196F, PRO196G, PRO197F, PRO197G, PRO209F, PRO209G, PRO220F, PRO220G, PRO225F, PRO225G, PRO262F, PRO262G, SER176F, SER176G, SER226F, SER226G, SER257F, SER257G, SER258F, SER258G, SER286F, SER286G, SER297F, SER297G, SER300F, SER300G, SER303F, SER303G, THR174F, THR193F, THR193G, THR208F, THR208G, THR224F, THR224G, THR22F, THR22G, THR239F, THR239G, THR246F, THR246G, THR250F, THR250G, THR268F, THR268G, THR273F, THR273G, THR276F, THR276G, THR279F, THR279G, THR316F, THR316G, THR85F, THR85G, THR8F, THR8G, TRP181F, TRP181G, TRP235F, TRP235G, TRP319F, TRP319G, TYR189F, TYR234F, TYR234G, TYR238F, TYR238G, TYR275F, TYR275G, TYR278F, TYR278G, TYR289F, TYR289G, TYR290F, TYR290G, TYR294F, TYR294G, TYR82F, TYR82G, TYR83F, TYR83G, VAL192F, VAL192G, VAL249F, VAL249G, VAL259F, VAL259G, VAL265F, VAL265G, VAL266F, VAL266G, VAL29F, VAL29G, VAL302F, VAL302G, VAL331F, VAL331G, VAL333F, VAL333G, VAL55F, VAL55G
• F-H: ALA188F, ALA188H, ALA227F, ALA227H, ALA84F, ALA84H, ARG187F, ARG187H, ASN185F, ASN185H, ASP222F, ASP222H, GLN183F, GLN183H, GLU180F, GLU180H, GLY178F, GLY178H, GLY218F, GLY218H, HIS182F, HIS182H, LEU186F, LEU186H, LEU230F, LEU230H, PHE86F, PHE86H, PRO177F, PRO177H, PRO220F, PRO220H, PRO225F, PRO225H, SER176F, SER176H, SER226F, SER226H, THR184F, THR184H, THR224F, THR224H, THR85F, THR85H, TRP181F, TRP181H, TYR179F, TYR189F, TYR189H
• G-H: ALA188G, ALA188H, ALA214G, ALA214H, ALA233G, ALA233H, ARG187G, ARG187H, ASN185G, ASN185H, ASP199G, ASP199H, ASP204G, ASP204H, ASP206G, ASP206H, GLN183G, GLN183H, GLN198G, GLN198H, GLU180G, GLU180H, GLY171G, GLY171H, GLY191G, GLY191H, GLY203G, GLY203H, GLY211G, GLY211H, GLY215G, GLY215H, GLY216G, GLY216H, GLY218G, GLY218H, HIS182G, HIS182H, ILE170G, ILE170H, ILE190G, ILE190H, ILE200G, ILE200H, LEU186G, LEU186H, LEU205G, LEU205H, LEU207G, LEU207H, LEU217G, LEU217H, LEU219G, LEU219H, LEU230G, LEU230H, LYS168G, LYS168H, LYS236G, LYS236H, LYS237G, LYS237H, MET201G, MET201H, MET202G, MET202H, PHE210G, PHE210H, PHE229G, PHE229H, PRO194G, PRO194H, PRO196G, PRO196H, PRO197G, PRO197H, PRO209G, PRO209H, PRO220G, PRO220H, THR169G, THR169H, THR184G, THR184H, THR193G, THR193H, THR208G, THR208H, TRP181G, TRP181H, TRP235G, TRP235H, TYR179G, TYR179H, TYR189G, TYR189H, TYR234G, TYR234H, TYR238G, TYR238H, VAL172G, VAL172H, VAL192G, VAL192H, VAL232G, VAL232H