3PRX

structure of complement c5 in complex with cvf and ssl7

• Total interactions analyzed: 15
• Total true interactions: 7
• Strongest Interaction:
  • Chains: A-X
  • Int. Res.: 98
  • Norm. En. per Res.: -3.3228
• Hub Node: A(3)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-88.784	-55.1099	-473.432	-617.3259	260	88	4	24042	3	59	59
A-C	-33.4476	26.595	-267.814	-274.6666	173	61	3	14012	3	28	47
A-X	-76.2874	-56.1122	-193.237	-325.6366	98	28	4	8201	5	32	25
B-X	-17.4396	10.6796	-38.6087	-45.3687	43	7	0	2048	0	17	20
C-D	-92.6687	-49.9767	-509.699	-652.3445	263	85	4	24336	3	60	59
C-Y	-78.222	-58.1754	-167.065	-303.4625	98	41	4	8357	5	32	25
D-Y	0.0	14.1487	-51.7432	-37.5945	46	7	0	2640	0	15	21

Interface residues

• A-B: ALA396B, ALA418A, ALA448B, ALA475A, ALA521A, ALA561B, ALA562B, ALA579A, ALA581A, ALA741B, ALA898B, ALA903B, ARG250B, ARG412A, ARG497B, ARG498B, ARG515A, ARG748B, ARG809B, ARG849A, ARG885A, ASN401B, ASN405B, ASN416B, ASN423A, ASN459B, ASN463B, ASN465B, ASN472A, ASN483A, ASN502B, ASN507B, ASN527A, ASN554B, ASN838B, ASN841B, ASP403A, ASP405A, ASP414A, ASP415A, ASP458B, ASP468A, ASP471A, ASP499B, ASP520A, ASP553B, ASP578A, ASP580A, ASP737B, ASP744B, ASP822A, ASP843B, ASP874A, ASP907B, CYS856A, CYS883A, GLN495B, GLN501B, GLN524A, GLN557B, GLN769B, GLN854A, GLN869B, GLN876A, GLN886A, GLN901B, GLU361B, GLU453B, GLU480A, GLU516A, GLU736B, GLU842B, GLU902B, GLU915A, GLU921A, GLY357B, GLY366A, GLY384A, GLY385A, GLY388B, GLY427A, GLY457B, GLY468B, GLY479A, GLY500B, GLY738B, GLY852A, GLY877A, GLY908B, GLY919A, HIS376B, HIS385B, HIS446B, HIS473A, HIS481A, HIS509B, HIS875A, ILE367A, ILE371A, ILE399B, ILE402B, ILE449B, ILE454B, ILE484A, ILE485A, ILE510B, ILE526A, ILE528A, ILE556B, ILE740B, ILE745B, ILE746B, ILE844B, ILE872B, ILE873A, ILE922A, LEU391B, LEU398B, LEU400B, LEU404A, LEU404B, LEU422A, LEU424A, LEU460B, LEU473B, LEU476A, LEU477A, LEU482A, LEU503B, LEU508B, LEU555B, LEU904B, LEU914A, LYS241A, LYS355B, LYS372A, LYS397B, LYS408A, LYS455B, LYS467B, LYS474A, LYS489A, LYS517A, LYS541B, LYS564B, LYS812B, LYS818A, LYS821A, LYS858A, LYS879A, LYS882A, LYS887A, LYS920A, MET358B, MET387B, MET506B, MET558B, MET563B, MET811B, MET853A, PHE384B, PHE420A, PHE464B, PHE479B, PHE518A, PHE739B, PHE814B, PHE815B, PHE820A, PHE855A, PHE870B, PHE918A, PRO356B, PRO359B, PRO365A, PRO368A, PRO370A, PRO378B, PRO403B, PRO425A, PRO456B, PRO461B, PRO488A, PRO491A, PRO496B, PRO529A, PRO559B, PRO577A, PRO871A, PRO871B, SER386B, SER392B, SER402A, SER407A, SER409A, SER419A, SER426A, SER451B, SER490A, SER519A, SER522A, SER525A, SER583A, SER768B, SER851A, SER880A, SER881A, SER899B, SER906B, SER913A, THR389B, THR390B, THR394A, THR411A, THR450B, THR452B, THR470A, THR487A, THR505B, THR850A, THR878A, THR916A, TRP469A, TRP905B, TRP917A, TYR235A, TYR352A, TYR360B, TYR369A, TYR466A, TYR499A, TYR523A, TYR779B, TYR839B, TYR845B, TYR848A, VAL373A, VAL379B, VAL380B, VAL383A, VAL386A, VAL410A, VAL413A, VAL417A, VAL421A, VAL428A, VAL447B, VAL462B, VAL466B, VAL478A, VAL486A, VAL504B, VAL530A, VAL810B, VAL813B, VAL840B, VAL846B, VAL857A, VAL884A, VAL900B
• A-C: ALA1062A, ALA1062C, ARG116A, ARG116C, ARG1308A, ARG1308C, ARG947A, ARG947C, ASN1029A, ASN1029C, ASN1032A, ASN1032C, ASN1096A, ASN1096C, ASN1098A, ASN1098C, ASN1102A, ASN1102C, ASN1110A, ASN1110C, ASN97A, ASN97C, ASP1037A, ASP1063A, ASP1063C, ASP1157A, ASP1157C, ASP1165A, ASP1165C, ASP1330A, ASP1330C, ASP61A, ASP61C, CYS1101A, CYS1101C, CYS1159A, CYS1159C, GLN1097A, GLN1097C, GLN1306A, GLN1306C, GLN91A, GLN91C, GLN96A, GLN96C, GLU1026A, GLU1026C, GLU1109A, GLU1109C, GLU664C, GLY1028A, GLY1028C, GLY94A, GLY94C, GLY95A, GLY95C, HIS1023A, HIS1023C, HIS1030A, HIS1030C, HIS1035A, HIS1035C, ILE1033A, ILE1033C, ILE1100A, ILE1100C, ILE1158A, ILE1158C, ILE1164A, ILE1164C, ILE119A, LEU1025A, LEU1025C, LEU1039A, LEU1039C, LEU1104A, LEU1104C, LEU1105A, LEU1105C, LEU1161A, LEU1161C, LEU1302A, LEU1302C, LEU1303A, LEU1307A, LEU1307C, LEU1309A, LEU1309C, LEU92A, LEU92C, LEU982A, LYS1042A, LYS1042C, LYS1046A, LYS1091A, LYS1091C, LYS115C, LYS1163A, LYS1163C, LYS1305A, LYS1305C, LYS1331A, LYS1331C, LYS62A, LYS62C, LYS63A, LYS63C, LYS90A, LYS90C, PHE1022A, PHE1022C, PHE1034A, PHE1034C, PHE1156A, PHE1156C, PHE64A, PHE64C, PRO1038A, PRO1038C, PRO1160A, PRO1160C, PRO118A, PRO118C, PRO60A, PRO60C, PRO93A, PRO93C, PRO98A, PRO98C, SER100A, SER100C, SER1036A, SER1065C, SER1099A, SER1099C, SER1103A, SER1103C, SER114C, SER1310A, SER58A, SER58C, THR1027A, THR1027C, THR1166A, THR1166C, THR1329A, TRP1031A, TRP1031C, TRP1106A, TRP1106C, TYR101A, TYR101C, TYR1024A, TYR1024C, TYR103A, TYR103C, TYR1064A, TYR1064C, TYR1092A, TYR1092C, TYR121A, TYR121C, TYR59A, TYR59C, TYR66C, VAL1108A, VAL1108C, VAL1162A, VAL1162C, VAL1304A, VAL1304C, VAL99A, VAL99C
• A-X: ALA148X, ALA83A, ARG222X, ARG515A, ASN133X, ASN139X, ASN142X, ASN149A, ASN176X, ASN192X, ASN229X, ASN38A, ASN500A, ASN527A, ASN533A, ASN77A, ASN806A, ASN81A, ASP145X, ASP147X, ASP151A, ASP151X, ASP195X, GLN156X, GLN42A, GLN524A, GLN532A, GLN80A, GLU131X, GLU144X, GLU196X, GLU37A, GLU516A, GLU76A, GLY143X, GLY187X, GLY223X, GLY513A, GLY69A, HIS179A, HIS498A, HIS511A, HIS70A, HIS72A, ILE150X, ILE180A, ILE190X, ILE224X, ILE228X, ILE39A, ILE503A, ILE509A, ILE510A, ILE526A, ILE528A, ILE84A, LEU136X, LEU146X, LEU154X, LEU85A, LYS140X, LYS153A, LYS156A, LYS188X, LYS198X, LYS508A, LYS517A, LYS78A, PHE137X, PHE153X, PHE512A, PHE518A, PHE79A, PRO135X, PRO154A, PRO529A, SER130X, SER149X, SER152X, SER225X, SER36A, SER505A, SER68A, SER75A, SER82A, THR132X, THR134X, THR227X, THR514A, THR531A, THR807A, TYR177X, TYR499A, TYR501A, VAL138X, VAL141X, VAL40A, VAL71A
• B-X: ALA383B, ARG414B, ARG422B, ARG44X, ARG48X, ASN142X, ASN175X, ASN176X, ASN229X, ASN401B, ASN416B, ASP145X, ASP419B, ASP42X, ASP45X, GLN230X, GLN425B, GLU382B, GLU423B, GLY143X, GLY178X, GLY182X, GLY418B, HIS385B, HIS417B, HIS47X, ILE43X, LEU420B, LEU46X, LYS140X, LYS181X, MET387B, PHE384B, PRO421B, SER184X, SER51X, THR183X, TYR177X, TYR180X, TYR49X, VAL141X, VAL174X, VAL380B
• C-D: ALA375D, ALA396D, ALA406D, ALA418C, ALA448D, ALA475C, ALA521C, ALA561D, ALA562D, ALA579C, ALA581C, ALA741D, ALA898D, ALA903D, ARG250D, ARG412C, ARG497D, ARG498D, ARG515C, ARG809D, ARG849C, ARG885C, ASN401D, ASN405D, ASN416D, ASN423C, ASN459D, ASN463D, ASN465D, ASN472C, ASN483C, ASN502D, ASN507D, ASN527C, ASN554D, ASN841D, ASP403C, ASP405C, ASP414C, ASP415C, ASP458D, ASP468C, ASP471C, ASP499D, ASP520C, ASP553D, ASP578C, ASP580C, ASP737D, ASP744D, ASP822C, ASP843D, ASP874C, ASP907D, CYS856C, CYS883C, GLN495D, GLN501D, GLN524C, GLN557D, GLN586C, GLN769D, GLN854C, GLN869D, GLN876C, GLN886C, GLN901D, GLU361D, GLU453D, GLU480C, GLU516C, GLU736D, GLU842D, GLU902D, GLU915C, GLU921C, GLY357D, GLY366C, GLY384C, GLY385C, GLY388D, GLY427C, GLY457D, GLY468D, GLY479C, GLY500D, GLY738D, GLY852C, GLY877C, GLY908D, GLY919C, HIS376D, HIS385D, HIS446D, HIS473C, HIS481C, HIS509D, HIS875C, ILE367C, ILE371C, ILE399D, ILE402D, ILE449D, ILE454D, ILE484C, ILE485C, ILE510D, ILE526C, ILE528C, ILE556D, ILE740D, ILE745D, ILE746D, ILE844D, ILE872D, ILE873C, ILE922C, LEU362D, LEU391D, LEU398D, LEU400D, LEU404C, LEU404D, LEU422C, LEU424C, LEU460D, LEU476C, LEU477C, LEU482C, LEU503D, LEU508D, LEU555D, LEU904D, LEU914C, LYS241C, LYS355D, LYS372C, LYS397D, LYS408C, LYS455D, LYS467D, LYS474C, LYS489C, LYS517C, LYS541D, LYS564D, LYS812D, LYS818C, LYS821C, LYS858C, LYS882C, LYS920C, MET358D, MET387D, MET506D, MET558D, MET563D, MET811D, MET853C, PHE384D, PHE420C, PHE464D, PHE479D, PHE518C, PHE739D, PHE814D, PHE815D, PHE820C, PHE855C, PHE870D, PHE918C, PRO356D, PRO359D, PRO365C, PRO368C, PRO370C, PRO378D, PRO403D, PRO425C, PRO456D, PRO461D, PRO488C, PRO491C, PRO496D, PRO529C, PRO559D, PRO577C, PRO871C, PRO871D, SER381D, SER386D, SER392D, SER402C, SER407C, SER409C, SER419C, SER426C, SER451D, SER490C, SER519C, SER522C, SER525C, SER583C, SER768D, SER851C, SER880C, SER881C, SER899D, SER906D, SER913C, THR389D, THR390D, THR394C, THR411C, THR450D, THR452D, THR470C, THR487C, THR505D, THR547D, THR850C, THR878C, THR916C, TRP469C, TRP905D, TRP917C, TYR235C, TYR352C, TYR360D, TYR369C, TYR466C, TYR499C, TYR523C, TYR779D, TYR839D, TYR845D, TYR848C, VAL373C, VAL377D, VAL379D, VAL380D, VAL383C, VAL386C, VAL388C, VAL410C, VAL413C, VAL417C, VAL421C, VAL428C, VAL447D, VAL462D, VAL466D, VAL478C, VAL486C, VAL504D, VAL530C, VAL810D, VAL813D, VAL840D, VAL846D, VAL857C, VAL884C, VAL900D
• C-Y: ALA148Y, ALA83C, ARG222Y, ARG515C, ASN133Y, ASN139Y, ASN142Y, ASN176Y, ASN192Y, ASN229Y, ASN38C, ASN500C, ASN527C, ASN533C, ASN77C, ASN806C, ASN81C, ASP145Y, ASP147Y, ASP151C, ASP151Y, ASP195Y, GLN156Y, GLN42C, GLN524C, GLN532C, GLN80C, GLU131Y, GLU144Y, GLU196Y, GLU516C, GLU76C, GLY143Y, GLY187Y, GLY223Y, GLY513C, GLY69C, HIS179C, HIS498C, HIS511C, HIS70C, HIS72C, ILE150Y, ILE180C, ILE190Y, ILE224Y, ILE228Y, ILE39C, ILE503C, ILE509C, ILE510C, ILE526C, ILE528C, ILE84C, LEU136Y, LEU146Y, LEU154Y, LEU85C, LYS140Y, LYS153C, LYS156C, LYS188Y, LYS198Y, LYS508C, LYS517C, LYS78C, MET534C, PHE137Y, PHE153Y, PHE512C, PHE518C, PHE79C, PRO135Y, PRO154C, PRO529C, SER130Y, SER149Y, SER152Y, SER225Y, SER36C, SER505C, SER68C, SER75C, SER82C, THR132Y, THR134Y, THR227Y, THR497C, THR514C, THR531C, THR807C, TYR177Y, TYR499C, TYR501C, VAL138Y, VAL141Y, VAL40C, VAL71C
• D-Y: ALA383D, ARG414D, ARG422D, ARG44Y, ARG48Y, ASN142Y, ASN175Y, ASN176Y, ASN229Y, ASN401D, ASN416D, ASP145Y, ASP147Y, ASP419D, ASP42Y, ASP45Y, GLN230Y, GLN425D, GLU382D, GLU423D, GLY143Y, GLY178Y, GLY182Y, GLY418D, HIS385D, HIS417D, HIS47Y, ILE43Y, LEU179Y, LEU420D, LEU46Y, LYS140Y, LYS181Y, MET387D, PHE384D, PRO421D, SER184Y, SER51Y, THR183Y, TYR177Y, TYR180Y, TYR49Y, TYR50Y, VAL141Y, VAL174Y, VAL380D