3PRQ

crystal structure of cyanobacterial photosystem ii in complex with terbutryn (part 1 of 2). this file contains first monomer of psii dimer

• Total interactions analyzed: 190
• Total true interactions: 70
• Strongest Interaction:
  • Chains: A-D
  • Int. Res.: 423
  • Norm. En. per Res.: -4.3541
• Hub Node: A(13)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-42.0437	-63.7001	-135.0	-240.7438	68	15	4	6105	4	12	9
A-C	-89.1246	-15.0074	-844.216	-948.348	282	69	19	33206	6	30	31
A-D	-210.3993	-41.8289	-1589.57	-1841.7982	423	132	47	64641	11	54	60
A-E	-18.4711	5.0382	-66.1816	-79.6145	36	4	1	2878	0	6	6
A-F	-12.3639	-7.8626	-26.38	-46.6065	15	2	0	873	0	1	3
A-I	-20.922	-38.4555	-249.142	-308.5196	83	15	6	9136	4	7	11
A-J	0.0	0.0	-35.5547	-35.5547	23	2	1	1342	0	0	0
A-L	-11.3753	4.0754	-41.5713	-48.8711	38	5	1	1819	0	2	1
A-M	0.0	0.0	-4.2184	-4.2184	10	0	0	168	0	0	0
A-O	-48.11	-50.0623	-153.955	-252.1272	79	22	2	7670	0	25	20
A-T	-25.9251	1.1837	-114.857	-139.5983	52	10	4	5019	0	6	4
A-U	0.0	0.0	-25.8966	-25.8966	10	1	0	680	0	2	1
A-V	-26.8609	-6.9767	-119.322	-153.1596	61	4	3	5364	1	14	15
B-D	-129.4046	-13.1292	-714.954	-857.4878	258	42	28	28933	10	37	37
B-E	0.0	0.0	-5.9909	-5.9909	9	3	0	597	0	1	2
B-H	-120.2422	-19.8603	-514.158	-654.2606	157	59	10	20665	1	22	18
B-L	-30.0607	16.8282	-160.348	-173.5806	58	10	3	5776	0	6	7
B-M	0.0	4.2365	-10.3109	-6.0744	31	0	0	772	0	2	1
B-O	-46.0099	-65.7502	-189.838	-301.5981	76	14	2	7075	4	18	24
B-U	-8.2944	-10.8862	-92.3706	-111.5513	49	11	1	4195	1	22	20
B-V	0.0	0.0	-0.0178	-0.0178	3	0	0	14	0	1	2
B-X	0.0	0.0	-0.0251	-0.0251	6	0	0	15	0	0	0
C-D	-65.1184	-53.5111	-204.303	-322.9325	88	42	7	8262	2	12	16
C-I	-12.5128	-34.4811	-82.2996	-129.2935	44	10	1	3890	2	11	13
C-J	0.0	0.0	-5.1624	-5.1624	15	2	0	459	0	0	0
C-K	-9.0901	-11.298	-195.373	-215.7612	84	23	11	8677	1	7	6
C-O	-48.4344	-61.8373	-366.217	-476.4887	113	33	3	14150	4	21	19
C-T	0.0	-23.0206	-28.5823	-51.6029	16	1	0	1030	0	4	1
C-U	-17.3479	-8.3405	-111.452	-137.1404	47	10	3	4513	1	6	9
C-V	-17.0703	-38.3324	-198.842	-254.2447	96	13	5	9079	6	29	21
C-y	0.0	0.0	-1.7721	-1.7721	14	0	0	219	0	0	1
C-Z	0.0	10.6301	-80.9373	-70.3072	56	2	6	3720	0	2	2
D-E	-5.9328	-49.2365	-354.966	-410.1354	116	26	11	15225	2	14	15
D-F	-13.0186	0.0	-98.4592	-111.4778	57	9	5	4414	0	2	2
D-H	-5.6079	0.0	-57.5035	-63.1114	37	7	0	2513	0	1	1
D-I	0.0	0.0	-0.0027	-0.0027	2	0	0	1	0	0	0
D-J	0.0	0.0	-19.2919	-19.2919	18	2	0	657	0	0	0
D-K	0.0	0.0	-0.23	-0.23	3	0	0	19	0	0	1
D-L	0.0	0.0	-92.6992	-92.6992	51	4	0	3202	0	0	0
D-M	0.0	7.6048	-32.6498	-25.045	16	2	0	1317	0	1	4
D-O	-15.8755	21.104	-131.171	-125.9425	74	4	6	6453	4	34	33
D-T	0.0	0.0	-35.163	-35.163	35	1	3	1708	0	1	4
D-U	-6.7833	-3.756	-23.6413	-34.1806	15	1	1	932	0	3	2
D-V	0.0	4.4332	-32.0539	-27.6207	20	0	1	1421	0	3	4
D-X	-10.5004	-31.0789	-132.394	-173.9732	60	10	2	6056	2	9	8
E-F	0.0	-11.8235	-208.711	-220.5345	73	11	11	8071	0	4	4
E-H	0.0	0.0	-18.4714	-18.4714	10	0	0	655	0	1	0
E-J	-18.3315	-25.6554	-96.6077	-140.5945	39	25	2	4839	1	4	5
E-V	-9.1146	4.6216	-46.5614	-51.0543	31	5	3	1918	0	7	8
E-X	0.0	0.0	-0.0053	-0.0053	2	0	0	4	0	0	1
E-Y	0.0	0.0	-58.379	-58.379	51	4	0	4193	0	0	0
F-J	-3.9193	0.0	-74.5209	-78.4402	40	7	4	3370	0	0	0
F-V	0.0	-6.9513	-3.047	-9.9984	12	0	0	331	0	2	2
F-X	0.0	0.0	-0.1004	-0.1004	5	0	0	41	0	0	0
F-Y	0.0	0.0	-10.1861	-10.1861	25	0	0	804	0	0	0
H-L	0.0	-4.5438	-4.0507	-8.5946	4	1	0	196	0	2	0
H-X	-4.4313	0.0	-64.8019	-69.2332	35	6	3	2953	0	2	0
J-K	0.0	0.0	-23.6703	-23.6703	24	5	1	1272	0	0	0
J-V	0.0	0.0	-11.3684	-11.3684	8	2	0	567	0	0	0
J-y	0.0	0.0	-21.0556	-21.0556	25	1	0	1095	0	0	0
J-Y	0.0	0.0	-0.0278	-0.0278	5	0	0	17	0	0	0
K-y	0.0	0.0	-72.5392	-72.5392	49	9	6	4236	0	0	0
K-Z	0.0	0.0	-58.7526	-58.7526	35	12	3	2642	0	0	0
L-M	-28.5299	-17.4406	-210.209	-256.1795	60	16	14	8639	1	2	1
L-T	-2.6573	-9.6058	-161.221	-173.4841	52	6	11	6153	0	2	4
M-T	0.0	0.0	-24.294	-24.294	31	3	1	1641	0	1	3
O-U	0.0	8.1354	-107.471	-99.3356	64	8	11	5180	0	20	10
U-V	-31.9316	-15.0148	-155.885	-202.8315	66	5	4	6491	1	13	9
y-Z	0.0	0.0	-101.156	-101.156	43	15	7	4320	0	3	1
X-Y	0.0	0.0	-0.0003	-0.0003	2	0	0	1	0	0	0

Interface residues

• A-B: ALA233A, ALA250A, ALA251A, ARG225A, ARG257A, ARG334A, ARG384B, ARG472B, ARG476B, ARG7B, ASN234A, ASN247A, ASP477B, ASP483B, GLN261A, GLN490B, GLU226A, GLU229A, GLU231A, GLU235B, GLU485B, GLU489B, GLY236A, GLY253A, GLY256A, GLY2B, GLY481B, HIS252A, HIS337A, ILE13B, ILE224A, ILE248A, ILE482B, LEU218A, LEU223A, LEU3B, LEU486B, MET331A, PHE260A, PHE383B, PHE475B, PHE479B, PRO484B, PRO488B, PRO4B, SER221A, SER222A, SER232A, SER480B, SER487B, THR10B, THR220A, THR227A, THR228A, THR230A, THR245A, TRP5B, TYR235A, TYR246A, TYR254A, TYR262A, TYR6B, VAL11B, VAL219A, VAL249A, VAL330A, VAL478B, VAL491B
• A-C: ALA146A, ALA149A, ALA152A, ALA156A, ALA188A, ALA287A, ALA294A, ALA309C, ALA312C, ALA314C, ALA324A, ALA336A, ALA344A, ALA399C, ALA411C, ALA427C, ALA434C, ALA445C, ALA448C, ALA450C, ALA451C, ALA452C, ALA453C, ALA88A, ARG136A, ARG140A, ARG269A, ARG27A, ARG320C, ARG323A, ARG334A, ARG343C, ARG357C, ARG423C, ARG447C, ARG449C, ARG461C, ARG64A, ASN108A, ASN191A, ASN26A, ASN296A, ASN298A, ASN301A, ASN303A, ASN322A, ASN325A, ASN335A, ASN338A, ASN405C, ASN415C, ASN87A, ASP170A, ASP25A, ASP319A, ASP321C, ASP342A, ASP360C, ASP460C, ASP473C, ASP59A, ASP61A, CYS144A, CYS288C, GLN113A, GLN130A, GLN165A, GLN187A, GLN199A, GLN241A, GLN311C, GLN313C, GLU104A, GLU132A, GLU189A, GLU221C, GLU242A, GLU243A, GLU269C, GLU308C, GLU329A, GLU333A, GLU348C, GLU354C, GLU413C, GLU456C, GLU464C, GLU65A, GLU98A, GLY128A, GLY138A, GLY164A, GLY166A, GLY171A, GLY219C, GLY220C, GLY240A, GLY289A, GLY299A, GLY306C, GLY327A, GLY333C, GLY336C, GLY338C, GLY352C, GLY353C, GLY402C, GLY408C, GLY409C, GLY440C, GLY446C, GLY454C, GLY458C, GLY62A, GLY90A, HIS190A, HIS195A, HIS304A, HIS332A, HIS337A, HIS398C, HIS430C, HIS441C, HIS444C, HIS92A, ILE116A, ILE143A, ILE160A, ILE163A, ILE192A, ILE265C, ILE290A, ILE307A, ILE319C, ILE321A, ILE350C, ILE414C, ILE459C, ILE60A, ILE63A, ILE89A, LEU121A, LEU133A, LEU137A, LEU151A, LEU159A, LEU200A, LEU288A, LEU28A, LEU297A, LEU318C, LEU326A, LEU337C, LEU341A, LEU341C, LEU343A, LEU401C, LEU404C, LEU426C, LEU433C, LEU438C, LEU442C, LEU467C, LEU472C, LEU91A, LYS339C, LYS457C, MET127A, MET139A, MET194A, MET293A, MET315C, MET328A, MET342C, MET356C, MET396C, MET469C, PHE117A, PHE155A, PHE168A, PHE186A, PHE197A, PHE218C, PHE239A, PHE273A, PHE284C, PHE285A, PHE292C, PHE295A, PHE300A, PHE302A, PHE317C, PHE339A, PHE33A, PHE33C, PHE351C, PHE358C, PHE431C, PHE435C, PHE436C, PHE437C, PHE455C, PHE93A, PRO141A, PRO150A, PRO162A, PRO196A, PRO217C, PRO304C, PRO307C, PRO334C, PRO340A, PRO345C, PRO400C, PRO465C, PRO470C, PRO95A, SER124A, SER134A, SER148A, SER153A, SER167A, SER169A, SER216C, SER23A, SER291A, SER305A, SER310C, SER344C, SER403C, SER406C, SER416C, SER421C, SER424C, SER429C, SER463C, SER468C, SER471C, SER86A, THR24A, THR287C, THR292A, THR305C, THR316C, THR335C, THR346C, THR355C, THR397C, THR412C, THR428C, TRP131A, TRP142A, TRP284A, TRP291C, TRP32A, TRP359C, TRP36C, TRP425C, TRP443C, TYR135A, TYR147A, TYR161A, TYR29A, TYR340C, TYR395C, TYR94A, VAL145A, VAL280A, VAL281A, VAL283A, VAL290C, VAL306A, VAL313A, VAL328C, VAL330A, VAL407C, VAL410C, VAL417C, VAL420C, VAL432C, VAL439C, VAL466C
• A-D: ALA133D, ALA143D, ALA145D, ALA146A, ALA148D, ALA149A, ALA170D, ALA176D, ALA177D, ALA188A, ALA203A, ALA208D, ALA209A, ALA212D, ALA213A, ALA216D, ALA229D, ALA233A, ALA234D, ALA240D, ALA249D, ALA250A, ALA251A, ALA260D, ALA263A, ALA276A, ALA277A, ALA318A, ALA324A, ALA327D, ALA330D, ALA336A, ALA344A, ALA351D, ALA64D, ALA77D, ALA81A, ARG128D, ARG129A, ARG134D, ARG136A, ARG139D, ARG140A, ARG180D, ARG225A, ARG233D, ARG24D, ARG251D, ARG257A, ARG265D, ARG269A, ARG26D, ARG27A, ARG304D, ARG323A, ARG326D, ARG334A, ARG348D, ARG64A, ASN142D, ASN181A, ASN190D, ASN191A, ASN194D, ASN220D, ASN234A, ASN236D, ASN247A, ASN250D, ASN263D, ASN266A, ASN267A, ASN26A, ASN301A, ASN303A, ASN312A, ASN315A, ASN318D, ASN322A, ASN322D, ASN325A, ASN335A, ASN338A, ASN350D, ASN72D, ASN75A, ASN76A, ASP225D, ASP25A, ASP25D, ASP297D, ASP308A, ASP319A, ASP333D, ASP342A, ASP59A, ASP61A, CYS125A, CYS144A, CYS211D, CYS212A, CYS71D, GLN129D, GLN130A, GLN186D, GLN187A, GLN199A, GLN224D, GLN239D, GLN241A, GLN255D, GLN261A, GLN301D, GLN332D, GLN334D, GLU131D, GLU132A, GLU189A, GLU219D, GLU226A, GLU231A, GLU241D, GLU242A, GLU242D, GLU243A, GLU244A, GLU310D, GLU312D, GLU323D, GLU329A, GLU333A, GLU65A, GLU69D, GLY124D, GLY128A, GLY137D, GLY138A, GLY171A, GLY174D, GLY175A, GLY178A, GLY187D, GLY201A, GLY203D, GLY204A, GLY206D, GLY207A, GLY207D, GLY208A, GLY215D, GLY216A, GLY226D, GLY228D, GLY236A, GLY240A, GLY253A, GLY256A, GLY258D, GLY278D, GLY299A, GLY31A, GLY324D, GLY327A, GLY349D, GLY34A, GLY62D, GLY69A, GLY70D, GLY74A, GLY80A, HIS195A, HIS197D, HIS198A, HIS214D, HIS215A, HIS252A, HIS268D, HIS272A, HIS304A, HIS332A, HIS337A, HIS61D, ILE132D, ILE143A, ILE144D, ILE176A, ILE178D, ILE184A, ILE192A, ILE213D, ILE224A, ILE248A, ILE256D, ILE259A, ILE259D, ILE299D, ILE307A, ILE314A, ILE320A, ILE321A, ILE325D, ILE60A, ILE63A, ILE77A, ILE78A, LEU127D, LEU133A, LEU135D, LEU137A, LEU174A, LEU182D, LEU183D, LEU193A, LEU193D, LEU205D, LEU209D, LEU210A, LEU210D, LEU218A, LEU222D, LEU223A, LEU258A, LEU267D, LEU271A, LEU272D, LEU275A, LEU279D, LEU28A, LEU319D, LEU320D, LEU321D, LEU326A, LEU341A, LEU343A, LEU346D, LEU352D, LEU37D, LEU63D, LEU71A, LEU72A, LEU74D, LYS238A, LYS23D, LYS264D, LYS317D, MET126D, MET127A, MET139A, MET172A, MET183A, MET194A, MET198D, MET214A, MET246D, MET271D, MET328A, MET329D, MET331A, MET37A, PHE125D, PHE130D, PHE146D, PHE168D, PHE169D, PHE173D, PHE179D, PHE180A, PHE181D, PHE182A, PHE184D, PHE186A, PHE188D, PHE206A, PHE211A, PHE223D, PHE232D, PHE235D, PHE239A, PHE252D, PHE255A, PHE257D, PHE260A, PHE261D, PHE269D, PHE270D, PHE273A, PHE273D, PHE274A, PHE27D, PHE298D, PHE29D, PHE300A, PHE302A, PHE311D, PHE314D, PHE339A, PHE33A, PHE341D, PHE38D, PHE73D, PRO140D, PRO141A, PRO149D, PRO150A, PRO171D, PRO173A, PRO195D, PRO196A, PRO237D, PRO275D, PRO279A, PRO309D, PRO331D, PRO335D, PRO340A, PRO347D, PRO57A, PRO66A, PRO84A, SER134A, SER169A, SER172D, SER177A, SER217A, SER221A, SER222A, SER230D, SER232A, SER23A, SER245D, SER254D, SER262D, SER268A, SER270A, SER282D, SER295D, SER300D, SER305A, SER33D, SER57D, SER65D, SER66D, SER68A, SER70A, SER79D, THR179A, THR192D, THR217D, THR220A, THR221D, THR227A, THR228A, THR22A, THR231D, THR238D, THR243D, THR245A, THR248D, THR24A, THR277D, THR286A, THR313D, THR316A, THR316D, THR56D, THR60D, THR75D, THR79A, THR80D, TRP111D, TRP131A, TRP142A, TRP191D, TRP253D, TRP266D, TRP278A, TRP317A, TRP328D, TRP58D, TYR126A, TYR135A, TYR141D, TYR147A, TYR235A, TYR237A, TYR244D, TYR246A, TYR254A, TYR262A, TYR29A, TYR315D, TYR73A, VAL136D, VAL138D, VAL145A, VAL152D, VAL175D, VAL185A, VAL201D, VAL202A, VAL204D, VAL205A, VAL218D, VAL219A, VAL247D, VAL249A, VAL274D, VAL276D, VAL280A, VAL281A, VAL283A, VAL28D, VAL306A, VAL30A, VAL30D, VAL313A, VAL330A, VAL58A, VAL67A, VAL76D, VAL78D, VAL82A, VAL83A
• A-E: ALA309A, ALA57E, ARG257A, ARG51E, ARG61E, ASN312A, ASN315A, ASP308A, ASP53E, GLN261A, GLN58E, GLN60E, GLU59E, GLU7E, GLY311A, GLY3E, HIS252A, ILE307A, ILE314A, ILE63E, LYS310A, PHE10E, PHE260A, PRO50E, PRO52E, PRO9E, SER11E, SER54E, THR316A, THR4E, THR5E, TYR262A, TYR55E, TYR56E, VAL306A, VAL313A
• A-F: ALA309A, ARG19F, ARG45F, ASN312A, ASP308A, GLN44F, GLY311A, ILE307A, ILE314A, LYS310A, PHE260A, SER305A, TYR262A, VAL306A, VAL313A
• A-I: ALA100A, ALA29I, ALA99A, ARG129A, ARG136A, ARG16A, ARG30I, ARG34I, ASN19A, ASN31I, ASP103A, ASP27I, CYS125A, CYS18A, GLU104A, GLU132A, GLU15A, GLU2I, GLU98A, GLY128A, GLY138A, GLY22I, GLY26I, GLY31A, GLY34A, HIS118A, ILE36A, ILE38A, ILE6I, ILE96A, LEU102A, LEU114A, LEU121A, LEU133A, LEU137A, LEU17I, LEU18I, LEU24I, LEU4I, LYS33I, LYS35I, LYS5I, MET139A, MET1I, MET37A, PHE14I, PHE15I, PHE17A, PHE19I, PHE21I, PHE23I, PHE33A, PHE93A, PRO28I, PRO32I, PRO39A, PRO95A, SER101A, SER134A, SER23A, SER25I, THR13I, THR22A, THR24A, THR3I, THR40A, THR7I, TRP105A, TRP131A, TRP14A, TRP20A, TRP32A, TRP97A, TYR135A, TYR29A, TYR9I, VAL11I, VAL12I, VAL16I, VAL20I, VAL21A, VAL35A, VAL8I
• A-J: ALA309A, ALA32J, ASN301A, ASN303A, ASP308A, GLY311A, GLY35J, GLY37J, HIS304A, ILE307A, ILE314A, LEU36J, LEU40J, PHE29J, PHE300A, PHE302A, SER305A, SER38J, SER39J, THR316A, TYR33J, VAL306A, VAL313A
• A-L: ALA28L, ARG14L, ASN13L, ASN234A, ASN37L, ASN6L, ASN75A, ASN76A, GLN8L, GLU11L, GLU231A, GLY80A, ILE176A, ILE77A, ILE78A, LEU12L, LEU19L, LEU29L, LEU30L, LEU71A, PHE180A, PHE31L, PHE35L, PHE36L, PHE52A, PRO9L, SER16L, SER177A, SER232A, SER32L, SER33L, THR15L, THR228A, THR230A, THR79A, TYR235A, TYR34L, VAL26L
• A-M: ASN75A, ASN76A, GLY74A, LEU71A, MET1M, THR29M, THR79A, TYR235A, TYR73A, VAL3M
• A-O: ALA100A, ALA137O, ALA336A, ALA55A, ALA88A, ALA99A, ARG141O, ARG178O, ARG188O, ARG334A, ARG64A, ARG99O, ASN108A, ASN181O, ASN335A, ASP103A, ASP184O, ASP250O, ASP59A, GLN130O, GLN135O, GLU100O, GLU104A, GLU140O, GLU333A, GLU65A, GLU98A, GLY109A, GLY138O, GLY139O, GLY187O, GLY193O, GLY38O, GLY90A, HIS92A, ILE142O, ILE63A, ILE89A, LEU102A, LEU106A, LEU144O, LEU145O, LEU183O, LEU96O, LYS186O, LYS95O, MET136O, MET331A, PHE182O, PHE93A, PRO131O, PRO143O, PRO185O, PRO56A, PRO57A, PRO66A, PRO95A, SER101A, SER68A, SER85A, SER86A, THR101O, THR102O, THR133O, THR179O, THR98O, TRP105A, TYR107A, TYR177O, TYR194O, TYR73A, TYR94A, VAL132O, VAL134O, VAL330A, VAL37O, VAL58A, VAL67A, VAL97O
• A-T: ALA11T, ALA20T, ALA54A, ARG24T, ARG27A, ARG28T, ASN75A, ASN76A, GLN241A, GLU242A, GLU25T, GLU2T, GLY240A, GLY74A, ILE14T, ILE21T, ILE29T, ILE46A, ILE4T, ILE53A, ILE77A, ILE78A, ILE9T, LEU28A, LEU71A, LEU72A, LYS238A, LYS31T, LYS32T, MET1T, PHE10T, PHE18T, PHE22T, PHE239A, PHE23T, PHE48A, PHE52A, PHE8T, PRO26T, PRO27T, SER70A, THR30T, THR3T, THR45A, THR5T, THR79A, TYR235A, TYR237A, TYR6T, TYR73A, VAL49A, VAL7T
• A-U: ASN129U, ASN338A, GLY131U, HIS337A, LEU132U, LEU341A, LYS134U, PHE339A, PRO340A, TYR133U
• A-V: ALA27V, ALA309A, ARG323A, ASN303A, ASN312A, ASN315A, ASN322A, ASN75V, ASP308A, ASP319A, ASP342A, CYS66V, GLU148V, GLU28V, GLU329A, GLU32V, GLU49V, GLY153V, GLY159V, GLY311A, GLY327A, GLY69V, HIS304A, HIS332A, ILE151V, ILE307A, ILE314A, ILE320A, ILE71V, LEU152V, LEU29V, LEU326A, LEU341A, LEU343A, LEU34V, LEU53V, LYS150V, LYS155V, LYS160V, LYS310A, LYS56V, LYS73V, PHE339A, PRO149V, PRO340A, PRO76V, SER65V, SER77V, THR30V, THR72V, THR74V, TRP156V, TYR162V, TYR163V, TYR52V, VAL147V, VAL161V, VAL313A, VAL330A, VAL33V, VAL68V
• B-D: ALA133D, ALA143D, ALA145D, ALA148D, ALA151D, ALA170D, ALA228B, ALA253B, ALA283D, ALA290D, ALA320B, ALA327D, ALA330D, ALA351D, ALA361B, ALA379B, ALA386B, ALA454B, ALA456B, ALA459B, ALA471B, ARG128D, ARG12D, ARG134D, ARG139D, ARG180D, ARG224B, ARG230B, ARG24D, ARG265D, ARG26D, ARG272B, ARG294D, ARG326B, ARG326D, ARG348D, ARG357B, ARG358B, ARG384B, ARG385B, ARG444B, ARG448B, ARG472B, ARG476B, ARG7B, ASN190D, ASN194D, ASN292D, ASN318B, ASN322D, ASN338D, ASN350D, ASN438B, ASN83D, ASP16D, ASP19D, ASP20D, ASP25D, ASP276B, ASP297D, ASP333D, ASP380B, ASP440B, ASP477B, ASP483B, GLN129D, GLN164D, GLN239D, GLN334D, GLN394B, GLN395B, GLN490B, GLU131D, GLU302D, GLU323D, GLU337D, GLU343D, GLU344D, GLU364B, GLU387B, GLU485B, GLU489B, GLY137D, GLY13D, GLY163D, GLY187D, GLY254B, GLY285D, GLY288D, GLY322B, GLY323B, GLY333B, GLY349D, GLY375B, GLY441B, GLY449B, GLY465B, GLY470B, GLY481B, GLY86D, HIS189D, HIS197D, HIS336D, HIS455B, HIS466B, HIS469B, HIS87D, ILE123D, ILE132D, ILE144D, ILE150D, ILE159D, ILE17D, ILE284D, ILE299D, ILE303D, ILE325D, ILE369B, ILE381B, ILE425B, ILE442B, ILE467B, ILE482B, LEU122D, LEU127D, LEU135D, LEU158D, LEU162D, LEU193D, LEU272D, LEU279D, LEU289D, LEU291D, LEU293D, LEU319D, LEU320D, LEU324B, LEU346D, LEU352D, LEU370B, LEU460B, LEU461B, LEU474B, LEU486B, LYS23D, LYS321B, LYS332B, LYS378B, LYS389B, MET126D, MET199D, MET256B, MET281D, MET329D, MET359B, PHE130D, PHE146D, PHE153D, PHE15D, PHE168D, PHE169D, PHE181D, PHE184D, PHE185D, PHE188D, PHE196D, PHE250B, PHE269D, PHE273D, PHE27D, PHE298D, PHE29D, PHE325B, PHE339D, PHE341D, PHE362B, PHE363B, PHE366B, PHE383B, PHE392B, PHE443B, PHE451B, PHE453B, PHE458B, PHE462B, PHE463B, PHE464B, PHE475B, PHE479B, PRO140D, PRO149D, PRO161D, PRO195D, PRO237D, PRO319B, PRO331D, PRO342D, PRO347D, PRO360B, PRO367B, PRO382B, PRO484B, PRO488B, SER147D, SER155D, SER165D, SER166D, SER282D, SER295D, SER300D, SER365B, SER388B, SER391B, SER439B, SER446B, SER480B, SER487B, THR238D, THR327B, THR371B, THR445B, THR452B, THR473B, TRP14D, TRP167D, TRP191D, TRP257B, TRP266D, TRP280D, TRP328D, TRP32D, TRP450B, TRP468B, TRP5B, TYR141D, TYR160D, TYR258B, TYR273B, TYR296D, TYR315D, TYR390B, TYR6B, VAL136D, VAL138D, VAL152D, VAL154D, VAL156D, VAL276D, VAL286D, VAL287D, VAL340D, VAL345D, VAL368B, VAL376B, VAL377B, VAL457B, VAL478B, VAL491B
• B-E: GLN490B, GLU489B, GLY3E, GLY6E, PRO488B, SER487B, THR4E, THR5E, VAL491B
• B-H: ALA132B, ALA205B, ALA22H, ALA261B, ALA2H, ALA32H, ALA64H, ARG124B, ARG127B, ARG12H, ARG220B, ARG224B, ARG272B, ARG286B, ARG3H, ARG448B, ARG4H, ASN14B, ASN15H, ASN191B, ASN194B, ASN233B, ASN50H, ASN59H, ASP119B, ASP125B, ASP134B, ASP170B, ASP188B, ASP56H, ASP9H, GLN179B, GLN223B, GLN274B, GLN282B, GLU121B, GLU130B, GLU17H, GLU266B, GLU283B, GLY129B, GLY173B, GLY176B, GLY186B, GLY189B, GLY196B, GLY19H, GLY232B, GLY24H, GLY254B, GLY259B, GLY269B, GLY26H, GLY57H, GLY66H, GLY8H, HIS114B, HIS201B, HIS216B, ILE10H, ILE141B, ILE211B, ILE217B, ILE234B, ILE265B, ILE44H, ILE45H, ILE48H, LEU11H, LEU120B, LEU122B, LEU133B, LEU135B, LEU14H, LEU218B, LEU225B, LEU229B, LEU30H, LEU42H, LEU46H, LEU55H, LEU65H, LEU7H, LYS137B, LYS20H, LYS227B, LYS63H, MET138B, MET166B, MET231B, MET256B, MET31H, MET35H, PHE123B, PHE190B, PHE215B, PHE247B, PHE268B, PHE280B, PHE34H, PHE38H, PHE41H, PRO126B, PRO131B, PRO136B, PRO13H, PRO16B, PRO171B, PRO187B, PRO192B, PRO195B, PRO221B, PRO222B, PRO23H, PRO264B, PRO270B, PRO29H, SER169B, SER16H, SER260B, SER277B, SER51H, SER61H, THR128B, THR175B, THR255B, THR262B, THR263B, THR271B, THR27H, THR28H, THR5H, TRP113B, TRP118B, TRP167B, TRP257B, TRP25H, TRP62H, TRP6H, TYR117B, TYR172B, TYR18H, TYR193B, TYR226B, TYR258B, TYR273B, TYR279B, TYR49H, VAL116B, VAL168B, VAL181B, VAL208B, VAL219B, VAL21H, VAL251B, VAL58H, VAL60H
• B-L: ARG124B, ARG18B, ARG326B, ARG444B, ARG7B, ARG7L, ASN13L, ASN14B, ASN37L, ASN4L, ASN6L, ASP119B, ASP15B, ASP440B, GLN8L, GLU11L, GLU2L, GLY17B, GLY2B, GLY323B, HIS114B, HIS9B, ILE13B, ILE442B, LEU120B, LEU12B, LEU12L, LEU19L, LEU23L, LEU30L, LEU324B, LEU3B, LYS332B, MET1L, PHE31L, PHE325B, PHE35L, PHE36L, PRO131B, PRO16B, PRO3L, PRO4B, PRO5L, PRO9L, SER16L, SER33L, THR10B, THR327B, TRP115B, TRP118B, TRP5B, TYR117B, TYR34L, TYR6B, VAL10L, VAL116B, VAL11B, VAL8B
• B-M: ARG326B, ARG444B, ARG7B, ASN438B, ASN4M, ASP440B, GLN28M, GLN32M, GLN5M, GLU2M, GLY2B, GLY328B, GLY7M, HIS9B, LEU22M, LEU25M, LEU3B, LEU437B, LEU6M, LYS332B, PHE21M, PHE325B, PRO4B, THR29M, THR327B, TRP5B, TYR26M, TYR40B, TYR6B, VAL3M, VAL8B
• B-O: ALA180O, ALA191O, ALA197O, ALA199O, ALA203O, ALA386B, ARG188O, ARG326B, ARG384B, ARG385B, ARG422B, ARG57B, ASN181O, ASN212O, ASP195O, ASP334B, ASP433B, ASP440B, GLN202O, GLN338B, GLU205O, GLU206O, GLU364B, GLU387B, GLU428B, GLU431B, GLU435B, GLY187O, GLY189O, GLY193O, GLY316B, GLY333B, GLY335B, GLY441B, ILE198O, ILE315B, ILE381B, ILE425B, ILE429B, ILE442B, LEU183O, LEU190O, LEU200O, LEU208O, LYS186O, LYS204O, LYS214O, LYS321B, LYS341B, LYS418B, LYS423B, MET359B, PHE363B, PHE366B, PHE383B, PHE426B, PHE430B, PHE432B, PHE443B, PRO201O, PRO367B, PRO382B, PRO415B, SER192O, SER196O, SER365B, SER388B, SER419B, SER439B, THR434B, THR436B, TYR194O, TYR314B, TYR420B, VAL213O, VAL368B
• B-U: ALA386B, ALA50U, ALA63U, ALA64U, ARG384B, ARG385B, ASN130U, ASN41U, ASN61U, ASP380B, ASP44U, GLN394B, GLN395B, GLN67U, GLU387B, GLU38U, GLU393B, GLU45U, GLU53U, GLY131U, GLY396B, GLY48U, GLY52U, ILE381B, LEU121U, LEU132U, LEU39U, LEU47U, LYS134U, LYS349B, LYS389B, LYS418B, LYS46U, LYS54U, PHE383B, PHE392B, PRO382B, PRO414B, PRO415B, SER388B, SER391B, THR49U, THR60U, TYR133U, TYR390B, TYR51U, VAL40U, VAL42U, VAL43U
• B-V: ARG384B, LYS160V, VAL161V
• B-X: GLN47X, LYS45X, PRO187B, THR11X, VAL46X, VAL491B
• C-D: ALA229D, ALA234D, ALA240D, ALA249D, ALA34C, ALA351D, ALA37C, ALA40C, ARG233D, ARG251D, ARG41C, ARG447C, ARG461C, ASN220D, ASN236D, ASN250D, ASN350D, ASN405C, ASN72D, ASP225D, ASP460C, ASP473C, GLN224D, GLN239D, GLN255D, GLN313C, GLU219D, GLU227D, GLU241D, GLU242D, GLU29C, GLU354C, GLU456C, GLU462C, GLU464C, GLY226D, GLY228D, GLY258D, GLY32C, GLY333C, GLY349D, GLY454C, GLY458C, ILE256D, ILE43C, ILE459C, LEU222D, LEU352D, LEU404C, LEU467C, LEU472C, LEU74D, LYS339C, LYS457C, MET246D, MET469C, PHE223D, PHE232D, PHE235D, PHE252D, PHE33C, PHE455C, PRO334C, PRO465C, PRO470C, SER230D, SER245D, SER254D, SER30C, SER31C, SER463C, SER468C, SER471C, THR217D, THR221D, THR231D, THR243D, THR248D, THR335C, THR412C, TRP328D, TRP35C, TRP36C, TRP443C, TYR244D, VAL247D, VAL410C, VAL466C
• C-I: ALA260C, ALA263C, ALA29I, ALA450C, ALA451C, ALA452C, ALA453C, ARG261C, ARG262C, ARG30I, ARG34I, ARG449C, ASN31I, ASP27I, ASP460C, GLU456C, GLU462C, GLU464C, GLY26I, GLY454C, GLY458C, ILE265C, ILE459C, LEU24I, LYS152C, LYS33I, LYS35I, LYS457C, MET469C, PHE21I, PHE23I, PHE264C, PHE455C, PRO28I, PRO32I, PRO465C, SER25I, SER267C, SER463C, TRP259C, TRP266C, TYR274C, VAL20I, VAL466C
• C-J: ALA32J, ASN405C, ASN415C, ASN418C, GLY37J, ILE414C, LEU404C, LEU40J, PHE29J, SER38J, SER39J, SER406C, SER416C, TYR33J, VAL407C
• C-K: ALA14K, ALA16K, ALA34C, ALA36K, ALA37C, ALA55C, ALA64C, ALA66C, ALA73C, ARG41C, ARG46K, ASN39C, ASP19K, ASP23K, ASP27C, GLN28C, GLN40K, GLN84C, GLU29C, GLU71C, GLU78C, GLY126C, GLY32C, GLY38C, GLY44K, GLY58C, GLY65C, HIS56C, HIS74C, ILE134C, ILE28K, ILE60C, ILE76C, ILE89C, LEU119C, LEU11K, LEU21K, LEU25K, LEU31K, LEU33K, LEU42C, LEU59C, LEU69C, LEU72C, LEU88C, LYS10K, LYS48C, LYS79C, MET67C, PHE109C, PHE111C, PHE112C, PHE18K, PHE32K, PHE33C, PHE37K, PHE45K, PHE62C, PHE70C, PHE75C, PRO12K, PRO20K, PRO26K, PRO29K, PRO77C, SER122C, SER30C, SER31C, THR108C, THR68C, TRP35C, TRP36C, TRP39K, TRP63C, TYR15K, VAL113C, VAL116C, VAL130C, VAL22K, VAL24K, VAL27K, VAL30K, VAL43K, VAL61C
• C-O: ALA180O, ALA326C, ALA331C, ALA42O, ALA67O, ARG178O, ARG343C, ARG362C, ARG370C, ARG65O, ARG68O, ARG99O, ASN150O, ASN181O, ASN228C, ASN327C, ASN373C, ASN378C, ASN382C, ASN43O, ASP105O, ASP125O, ASP128O, ASP34O, ASP35O, ASP360C, ASP376C, CYS45O, CYS70O, GLN106O, GLN108O, GLN130O, GLN311C, GLN322C, GLN332C, GLN72O, GLU100O, GLU123O, GLU124O, GLU221C, GLU348C, GLU367C, GLY126O, GLY220C, GLY329C, GLY333C, GLY336C, GLY338C, GLY347C, GLY371C, GLY374C, GLY38O, GLY40O, ILE107O, ILE127O, ILE349C, ILE350C, ILE36O, ILE380C, LEU104O, LEU144O, LEU145O, LEU183O, LEU31O, LEU337C, LEU341C, LEU366C, LEU375C, LEU377C, LEU41O, LEU71O, LYS149O, LYS215C, LYS339C, LYS379C, LYS381C, LYS44O, MET251O, MET342C, PHE129O, PHE182O, PHE216O, PHE361C, PRO131O, PRO175O, PRO334C, PRO345C, PRO372C, PRO46O, PRO73O, SER103O, SER176O, SER330C, SER344C, THR101O, THR102O, THR133O, THR147O, THR179O, THR30O, THR32O, THR335C, THR346C, THR39O, THR98O, TRP359C, TYR177O, TYR33O, TYR340C, VAL132O, VAL174O, VAL328C, VAL37O
• C-T: ARG24T, ARG28T, ASP473C, GLU25T, ILE21T, ILE29T, LEU467C, LEU472C, PHE22T, PHE23T, PRO26T, PRO27T, PRO470C, SER471C, THR30T, VAL466C
• C-U: ALA326C, ALA331C, ALA63U, ALA76U, ARG127U, ARG320C, ASN129U, ASN130U, ASN327C, ASN61U, ASP126U, ASP321C, GLN313C, GLN322C, GLN332C, GLU123U, GLY124U, GLY125U, GLY131U, GLY325C, GLY333C, GLY336C, GLY338C, ILE62U, ILE66U, LEU132U, LEU318C, LEU324C, LEU78U, LYS323C, LYS339C, LYS381C, LYS77U, LYS81U, PHE317C, PHE65U, PRO334C, PRO73U, SER330C, THR74U, TYR128U, TYR133U, TYR340C, TYR72U, VAL122U, VAL328C, VAL80U
• C-V: ALA115V, ALA124V, ALA312C, ALA392C, ALA393C, ALA399C, ALA411C, ALA62V, ALA64V, ARG131V, ARG320C, ARG390C, ARG391C, ARG57V, ASN132V, ASN415C, ASN418C, ASN75V, ASP125V, ASP321C, CYS63V, CYS66V, GLN112V, GLN313C, GLN385C, GLN388C, GLN60V, GLN84C, GLU104C, GLU116V, GLU389C, GLU394C, GLU413C, GLU78C, GLU83C, GLY158V, GLY159V, GLY408C, GLY409C, GLY69V, GLY70V, HIS118V, HIS144V, HIS398C, HIS67V, ILE114V, ILE126V, ILE319C, ILE414C, ILE71V, ILE76C, LEU133V, LEU152V, LEU324C, LEU78V, LYS129V, LYS155V, LYS160V, LYS323C, LYS56V, LYS73V, LYS79C, MET130V, MET396C, PHE127V, PHE317C, PHE419C, PHE59V, PRO119V, PRO128V, PRO386C, PRO76V, PRO77C, PRO80C, SER123V, SER416C, SER65V, SER77V, THR107V, THR316C, THR397C, THR412C, THR72V, THR74V, TRP156V, TRP387C, TYR162V, TYR163V, TYR61V, TYR82C, VAL105C, VAL117V, VAL407C, VAL410C, VAL417C, VAL68V
• C-y: ARG135C, ASN45y, GLN21y, GLY44y, HIS74C, ILE134C, ILE28y, ILE35y, LEU39y, LEU46y, LYS48C, PHE62C, PHE70C, VAL130C
• C-Z: ALA123C, ALA133C, ALA26Z, ALA28Z, ARG135C, ASN58Z, ASP32Z, ASP34Z, GLY126C, GLY128C, GLY129C, GLY136C, GLY22Z, GLY43Z, GLY45Z, GLY55Z, HIS132C, ILE120C, ILE134C, ILE40Z, ILE48Z, LEU119C, LEU12Z, LEU52Z, LEU9Z, LYS37Z, MET19Z, PHE109C, PHE112C, PHE127C, PHE41Z, PHE59Z, PHE5Z, PRO24Z, PRO30Z, SER121C, SER122C, SER16Z, SER29Z, SER44Z, TRP33Z, TRP47Z, TYR131C, TYR27Z, VAL113C, VAL116C, VAL117C, VAL124C, VAL130C, VAL13Z, VAL20Z, VAL23Z, VAL25Z, VAL51Z, VAL54Z, VAL62Z
• D-E: ALA43E, ALA57E, ALA64D, ALA72E, ALA82D, ALA97D, ARG103D, ARG24D, ARG26D, ARG51E, ARG61E, ARG69E, ARG8E, ASN338D, ASN83D, ASP100D, ASP25D, ASP45E, ASP68E, CYS105D, CYS71D, GLN106D, GLN332D, GLN334D, GLN60E, GLN74E, GLN75E, GLN98D, GLU337D, GLU69D, GLU71E, GLU77E, GLU7E, GLU81E, GLU96D, GLY108D, GLY34E, GLY3E, GLY41E, GLY47D, GLY48E, GLY51D, GLY62D, GLY6E, GLY70D, GLY86D, GLY94D, GLY99D, HIS336D, HIS61D, HIS87D, ILE63E, LEU107D, LEU110D, LEU42E, LEU63D, LEU65E, LEU68D, LEU80E, LEU83E, LEU89D, LEU90D, LEU91D, LEU92D, LYS73E, MET85D, PHE101D, PHE10E, PHE168D, PHE27D, PHE29D, PHE37E, PHE47E, PHE54D, PHE70E, PHE79E, PRO335D, PRO50E, PRO52E, PRO64E, PRO81D, PRO95D, SER166D, SER39E, SER54E, SER57D, SER62E, SER65D, SER66D, SER84D, SER88D, THR102D, THR49E, THR4E, THR50D, THR53D, THR56D, THR5E, THR60D, THR67E, THR78E, TRP104D, TRP167D, TRP35E, TRP58D, TYR44E, TYR55E, TYR56E, TYR59D, TYR67D, VAL28D, VAL38E, VAL46E, VAL55D, VAL66E, VAL76E
• D-F: ALA22F, ALA27F, ALA36F, ALA38F, ALA39F, ALA41D, ARG19F, ARG24D, ARG26D, ASN72D, CYS71D, GLN41F, GLU69D, GLY31D, GLY35F, GLY46D, GLY47D, GLY51D, GLY70D, HIS24F, ILE37F, ILE43F, LEU22D, LEU26F, LEU34F, LEU45D, LEU49D, LEU68D, MET40F, PHE27D, PHE29D, PHE32F, PHE33F, PHE38D, PHE54D, PHE73D, PRO29F, SER66D, THR17F, THR25F, THR30F, THR50D, THR52D, THR53D, TRP20F, TRP21D, TRP48D, TYR42D, TYR67D, VAL18F, VAL21F, VAL23F, VAL28D, VAL28F, VAL30D, VAL55D, VAL76D
• D-H: ALA97D, ASN50H, ASP16D, GLU47H, GLU96D, GLY13D, GLY86D, GLY94D, HIS87D, ILE48H, ILE54H, LEU116D, LEU162D, LEU18D, LEU39H, LEU43H, LEU46H, LEU53H, LEU89D, LEU90D, LEU91D, MET85D, PHE120D, PHE15D, PRO29H, PRO95D, SER51H, SER88D, THR112D, THR28H, THR52H, TRP14D, TRP167D, TRP25H, TRP32D, TRP93D, TYR49H
• D-I: GLN224D, LYS33I
• D-J: ALA32J, ALA64D, ASN72D, CYS71D, GLU69D, GLY31J, GLY35J, GLY37J, GLY70D, LEU36J, LEU68D, PHE28J, PHE29J, PHE73D, SER38J, SER66D, THR75D, TYR67D
• D-K: ARG233D, ARG46K, PHE45K
• D-L: ALA202D, ALA260D, ARG294D, ASN13L, ASN190D, ASN194D, ASN263D, ASN37L, ASP297D, GLN301D, GLU302D, GLY200D, HIS197D, ILE259D, ILE284D, ILE299D, ILE303D, LEU193D, LEU19L, LEU22L, LEU23L, LEU27L, LEU30L, MET198D, MET199D, MET281D, PHE196D, PHE257D, PHE261D, PHE269D, PHE270D, PHE273D, PHE298D, PHE31L, PHE35L, PHE36L, PRO195D, SER16L, SER262D, SER295D, SER300D, SER32L, SER33L, THR15L, THR192D, THR277D, TRP266D, TYR18L, TYR296D, TYR34L, VAL26L
• D-M: ARG304D, ASN4M, GLN301D, GLU2M, GLU302D, GLU307D, ILE299D, ILE303D, MET199D, MET1M, PHE14M, PHE298D, PHE311D, SER300D, THR313D, VAL3M
• D-O: ALA197O, ALA199O, ALA203O, ALA211O, ALA253O, ALA305D, ALA306D, ALA327D, ALA351D, ARG141O, ARG178O, ARG188O, ARG210O, ARG304D, ARG326D, ARG348D, ASN181O, ASN212O, ASN318D, ASN322D, ASN350D, ASP184O, ASP248O, ASP249O, ASP250O, ASP297D, ASP308D, GLN301D, GLU207O, GLU302D, GLU307D, GLU310D, GLU312D, GLU323D, GLU344D, GLY187O, GLY193O, GLY252O, GLY324D, GLY349D, HIS254O, ILE142O, ILE198O, ILE299D, ILE303D, LEU183O, LEU200O, LEU208O, LEU319D, LEU320D, LEU346D, LYS186O, LYS214O, LYS317D, MET251O, PHE182O, PHE298D, PHE311D, PRO143O, PRO185O, PRO201O, PRO309D, PRO347D, SER192O, SER196O, SER300D, THR179O, THR313D, THR316D, TYR177O, TYR194O, TYR296D, TYR315D, VAL345D
• D-T: ALA20T, ALA260D, ARG24T, ARG251D, ARG28T, ASN250D, ASN263D, GLN255D, GLN301D, GLU25T, GLU2T, GLY258D, ILE21T, ILE259D, ILE29T, LEU16T, LYS32T, MET246D, PHE17T, PHE18T, PHE19T, PHE22T, PHE23T, PHE257D, PHE261D, PHE298D, PRO26T, PRO27T, SER254D, SER262D, SER300D, THR30T, TRP253D, TYR6T, VAL247D
• D-U: ALA351D, ARG348D, ASN129U, ASN130U, ASN350D, GLU343D, GLU344D, GLY131U, GLY349D, LEU132U, LEU352D, LEU47U, LYS134U, TRP328D, TYR133U
• D-V: ALA351D, ARG348D, ARG81V, GLN332D, GLU343D, GLU344D, GLY158V, GLY159V, LEU346D, LEU352D, LYS155V, LYS160V, PHE341D, PRO331D, PRO342D, PRO76V, TRP328D, TYR162V, TYR163V, VAL161V
• D-X: ALA35X, ALA39X, ARG12D, ARG24D, ARG26D, ASP16D, ASP19D, ASP20D, ASP44X, GLN42X, GLN47X, GLN98D, GLU96D, GLY13D, GLY18X, GLY22X, GLY26X, GLY31D, GLY34D, GLY94D, GLY99D, HIS117D, ILE17D, ILE21X, ILE35D, ILE38X, ILE40X, ILE43X, LEU16X, LEU18D, LEU22D, LEU23X, LEU30X, LEU36D, LEU37X, LEU43D, LEU91D, LEU92D, LYS17X, LYS45X, PHE15D, PHE19X, PHE20X, PHE34X, PRO14X, PRO39D, PRO95D, SER15X, SER25X, SER41X, THR13X, THR33X, TRP14D, TRP21D, TRP32D, TRP93D, VAL29X, VAL30D, VAL36X, VAL46X
• E-F: ALA27F, ALA29E, ALA33E, ALA36F, ALA38F, ALA39F, ALA43E, ARG18E, ARG19F, ARG45F, ARG51E, ARG8E, ASP12E, ASP53E, GLN41F, GLN44F, GLU7E, GLY34E, GLY35F, GLY41E, GLY6E, HIS23E, HIS24F, ILE13E, ILE14E, ILE15F, ILE22E, ILE27E, ILE31F, ILE32E, ILE37F, ILE43F, LEU26F, LEU30E, LEU34F, LEU36E, LEU42E, MET40F, PHE10E, PHE16F, PHE31E, PHE32F, PHE33F, PHE37E, PHE42F, PHE47E, PRO14F, PRO28E, PRO29F, PRO52E, PRO9E, SER11E, SER12F, SER39E, THR17F, THR26E, THR30F, THR40E, THR49E, THR4E, THR5E, TRP20F, TRP35E, TYR13F, TYR19E, TYR44E, TYR55E, VAL11F, VAL18F, VAL23F, VAL28F, VAL38E, VAL46E
• E-H: ARG69E, ASN50H, GLU47H, ILE54H, LEU53H, PHE70E, SER51H, THR52H, TYR49H, VAL60H
• E-J: ALA14J, ALA17J, ARG18E, ARG51E, ARG7J, ARG8E, ASP12E, GLU4J, GLY5J, GLY6J, ILE12J, ILE13E, ILE14E, ILE22E, ILE24J, ILE8J, LEU10J, LEU27J, LEU36J, PHE10E, PHE28J, PHE31E, PRO50E, PRO52E, PRO9J, SER11E, SER16E, SER3J, THR15E, TRP11J, TRP20E, TRP35E, TYR19E, TYR44E, TYR55E, VAL13J, VAL16J, VAL17E, VAL21E
• E-V: ALA27V, ALA57E, ARG51E, ARG61E, ASP154V, ASP53E, GLN58E, GLN60E, GLU148V, GLU28V, GLU32V, GLU59E, GLY153V, ILE151V, LEU152V, LEU29V, LEU34V, LEU83E, LYS150V, LYS155V, LYS84E, PRO149V, PRO31V, PRO50E, PRO52E, SER54E, THR30V, TRP156V, TYR55E, TYR56E, VAL33V
• E-X: PHE70E, SER15X
• E-Y: ALA29E, ALA33E, ALA43E, ARG18E, ARG8E, ASP45E, GLY34E, GLY41E, HIS23E, ILE22E, ILE25E, ILE32E, LEU30E, LEU36E, LEU42E, PHE31E, PHE37E, PRO28E, SER39E, THR26E, THR40E, TRP35E, UNK10Y, UNK11Y, UNK12Y, UNK13Y, UNK14Y, UNK15Y, UNK16Y, UNK17Y, UNK18Y, UNK19Y, UNK1Y, UNK20Y, UNK21Y, UNK22Y, UNK23Y, UNK24Y, UNK25Y, UNK26Y, UNK2Y, UNK3Y, UNK4Y, UNK5Y, UNK6Y, UNK7Y, UNK8Y, UNK9Y, VAL21E, VAL38E, VAL46E
• F-J: ALA32J, ALA34J, ALA36F, ALA38F, ALA39F, ARG45F, GLN41F, GLN44F, GLU4J, GLY26J, GLY31J, GLY35F, GLY35J, GLY37J, GLY5J, ILE15F, ILE24J, ILE31F, ILE37F, ILE43F, LEU27J, LEU34F, LEU36J, LEU40J, MET40F, PHE28J, PHE29J, PHE33F, PHE42F, PRO14F, SER12F, SER38J, SER39J, THR30F, TYR13F, TYR30J, TYR33J, VAL11F, VAL21J, VAL25J
• F-V: ALA27V, ARG45F, GLN44F, GLU148V, GLU28V, GLU49V, ILE151V, LEU152V, LEU29V, LEU53V, LYS56V, TYR52V
• F-X: ILE40X, LEU37X, THR17F, VAL18F, VAL21F
• F-Y: HIS24F, ILE15F, PHE16F, PHE32F, PRO14F, SER12F, TRP20F, TYR13F, UNK10Y, UNK11Y, UNK14Y, UNK17Y, UNK18Y, UNK20Y, UNK21Y, UNK22Y, UNK23Y, UNK24Y, UNK25Y, UNK26Y, UNK27Y, UNK28Y, UNK7Y, UNK8Y, VAL28F
• H-L: ALA2H, ARG3H, GLU2L, MET1L
• H-X: ALA27X, ASP56H, GLU47H, GLY18X, GLY22X, GLY36H, GLY57H, ILE12X, ILE38X, ILE44H, ILE45H, ILE48H, ILE54H, LEU16X, LEU23X, LEU30X, LEU37H, LEU39H, LEU42H, LEU43H, LEU53H, LEU55H, LYS17X, PHE19X, PHE20X, PHE41H, PRO14X, SER15X, SER51H, THR11X, THR13X, THR52H, TRP25H, VAL40H, VAL58H
• J-K: ALA14J, ALA34K, ALA41K, ALA42K, GLN40K, GLY18J, GLY44K, ILE12J, ILE22J, LEU10J, LEU31K, LEU35K, MET19J, PHE37K, PHE45K, PRO9J, THR15J, TRP11J, TRP39K, VAL16J, VAL27K, VAL30K, VAL38K, VAL43K
• J-V: ARG57V, GLN60V, LEU40J, LEU53V, LYS56V, SER38J, SER39J, TYR52V
• J-y: ALA26y, ALA40y, GLY29y, GLY32y, ILE12J, ILE22J, ILE25y, ILE30y, ILE35y, ILE36y, LEU22y, LEU27J, LEU38y, LEU39y, LEU46y, MET19J, MET34y, PHE37y, PRO33y, PRO9J, THR15J, TRP11J, VAL16J, VAL23J, VAL41y
• J-Y: GLU4J, SER3J, UNK20Y, UNK24Y, UNK25Y
• K-y: ALA20y, ALA26y, ALA31y, ALA34K, ALA36K, ALA40y, ALA41K, ALA42K, ARG46K, ASN45y, ASP19K, ASP23K, GLN21y, GLN40K, GLY29y, GLY32y, GLY44K, ILE19y, ILE25y, ILE28K, ILE28y, ILE30y, ILE35y, ILE36y, LEU21K, LEU22y, LEU25K, LEU31K, LEU35K, LEU39y, LEU46y, MET24y, MET27y, MET34y, PHE18K, PHE32K, PHE37K, PHE37y, PRO20K, PRO29K, PRO33y, THR23y, TRP39K, VAL22K, VAL24K, VAL27K, VAL30K, VAL38K, VAL43K
• K-Z: ALA10Z, ALA11Z, ALA14K, ALA16K, ALA8Z, ASN58Z, GLN6Z, GLU13K, GLY55Z, ILE14Z, ILE17K, ILE28K, LEU11K, LEU12Z, LEU21K, LEU25K, LEU35K, LEU57Z, LEU7Z, LEU9Z, PHE17Z, PHE18K, PHE32K, PHE59Z, PHE5Z, PHE60Z, PRO12K, PRO24Z, THR2Z, TYR15K, VAL13Z, VAL20Z, VAL54Z, VAL61Z, VAL62Z
• L-M: ALA10M, ALA12M, ALA28L, ARG14L, ASN13L, ASN37L, ASN4M, GLN28M, GLN32M, GLN5M, GLU11L, GLU2M, GLU30M, GLY20L, GLY7M, ILE23M, ILE24L, ILE24M, ILE9M, LEU12L, LEU13M, LEU16M, LEU17L, LEU19L, LEU21L, LEU22L, LEU22M, LEU23L, LEU25L, LEU25M, LEU27L, LEU29L, LEU30L, LEU6M, LEU8M, MET1M, PHE14M, PHE21M, PHE31L, PHE35L, PHE36L, PRO18M, PRO9L, SER16L, SER19M, SER32L, SER33L, THR11M, THR15L, THR29M, TYR18L, TYR26M, TYR34L, VAL10L, VAL15M, VAL17M, VAL20M, VAL26L, VAL27M, VAL3M
• L-T: ALA11T, ALA15T, ALA20T, ALA28L, ARG14L, ARG24T, ASN13L, ASN37L, CYS12T, GLU25T, GLU2T, GLY20L, ILE13T, ILE14T, ILE21T, ILE24L, ILE4T, ILE9T, LEU12L, LEU16T, LEU17L, LEU19L, LEU21L, LEU22L, LEU23L, LEU25L, LEU27L, LEU29L, LEU30L, MET1T, PHE10T, PHE17T, PHE18T, PHE19T, PHE22T, PHE23T, PHE31L, PHE35L, PHE36L, PHE8T, PRO26T, SER16L, SER32L, SER33L, THR15L, THR3T, THR5T, TYR18L, TYR34L, TYR6T, VAL26L, VAL7T
• M-T: ALA10M, ALA12M, ASN4M, CYS12T, GLN5M, GLU25T, GLU2M, GLU2T, GLU30M, GLY7M, ILE23M, ILE4T, ILE9M, ILE9T, LEU16M, LEU16T, LEU22M, LEU8M, MET1M, MET1T, PHE14M, PHE23T, PHE8T, SER19M, THR11M, THR3T, THR5T, TYR26M, TYR6T, VAL15M, VAL3M
• O-U: ALA120U, ALA180O, ALA191O, ALA209O, ALA211O, ALA253O, ARG178O, ARG188O, ARG210O, ARG215O, ASN129U, ASN130U, ASN150O, ASN173O, ASN181O, ASN212O, ASN41U, ASP125O, ASP126U, ASP195O, ASP44U, GLU118U, GLU123U, GLU206O, GLU38U, GLU45U, GLY124U, GLY125U, GLY131U, GLY189O, GLY193O, GLY252O, LEU121U, LEU132U, LEU145O, LEU190O, LEU208O, LEU218O, LEU39U, LEU47U, LYS149O, LYS214O, LYS220O, LYS81U, MET251O, PHE129O, PHE182O, PHE216O, PRO175O, SER176O, SER192O, SER217O, THR119U, THR179O, THR219O, TYR194O, TYR51U, VAL117U, VAL122U, VAL174O, VAL213O, VAL40U, VAL42U, VAL43U
• U-V: ALA63U, ALA64U, ALA76U, ALA86V, ALA88V, ARG100U, ARG69U, ARG81V, ARG92V, ASN129U, ASN61U, ASN75V, ASP109V, ASP154V, ASP79V, ASP93V, GLN101U, GLN112V, GLN67U, GLU111V, GLU83V, GLY110V, GLY157V, GLY158V, GLY159V, GLY69V, GLY70U, GLY70V, ILE104U, ILE114V, ILE62U, ILE66U, ILE71V, LEU132U, LEU71U, LEU75U, LEU78V, LEU80V, LEU85V, LEU87V, LYS134U, LYS160V, LYS73V, LYS77U, PHE65U, PRO73U, PRO76V, PRO90V, PRO91V, SER77V, THR106V, THR107V, THR72V, THR74U, THR84V, THR89V, THR98U, TRP156V, TYR108V, TYR128U, TYR133U, TYR162V, TYR163V, TYR68U, TYR72U, VAL161V
• y-Z: ALA26Z, ALA26y, ALA28Z, ALA31y, ALA40y, ARG35Z, ARG42y, ARG43y, ASN45y, ASP32Z, GLN31Z, GLY22Z, GLY29y, GLY32y, GLY44y, ILE14Z, ILE21Z, ILE25y, ILE28y, ILE30y, ILE35y, ILE36y, LEU38y, LEU39y, LEU46y, MET24y, MET27y, MET34y, PHE17Z, PHE37y, PRO24Z, PRO30Z, PRO33y, SER29Z, THR23y, TRP33Z, TYR27Z, VAL13Z, VAL18Z, VAL20Z, VAL23Z, VAL25Z, VAL41y
• X-Y: ILE43X, UNK28Y