3PNS

crystal structure of uridine phosphorylase complexed with uracil from vibrio cholerae o1 biovar el tor

• Total interactions analyzed: 66
• Total true interactions: 26
• Strongest Interaction:
  • Chains: E-F
  • Int. Res.: 183
  • Norm. En. per Res.: -3.4964
• Hub Node: C(5)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-47.335	3.502	-522.977	-566.81	171	14	10	20336	0	49	42
A-J	0.0	0.0	-1.0855	-1.0855	11	0	0	152	0	5	4
A-L	-18.2745	22.2502	-48.5658	-44.59	28	1	0	1935	1	9	12
B-J	0.0	0.0	-0.0145	-0.0145	2	0	0	3	0	1	0
B-L	0.0	0.0	-26.4764	-26.4764	19	0	0	990	0	8	3
C-D	-52.3913	64.2073	-532.314	-520.498	170	16	10	19988	0	53	42
C-F	-20.4737	-11.2229	-25.0559	-56.7524	25	2	0	1037	0	8	7
C-I	-20.8267	-1.4794	-215.154	-237.4601	103	3	7	9431	3	14	15
C-J	-15.0097	-24.2762	-28.237	-67.5229	23	1	0	1074	0	8	7
C-K	0.0	0.0	-0.1957	-0.1957	7	0	0	62	0	3	2
D-E	-6.6098	-25.6573	-27.1649	-59.432	23	0	0	1067	0	8	7
D-F	-19.6059	-3.7437	-204.558	-227.9076	104	6	7	9107	4	16	16
D-I	-13.4892	-25.3727	-30.1602	-69.0222	23	0	0	1064	0	8	7
D-K	0.0	16.5874	-30.3087	-13.7213	16	3	1	1381	0	11	9
E-F	-78.1004	21.4296	-583.175	-639.8457	183	17	10	21393	0	52	44
E-I	-17.2914	-25.2614	-25.0808	-67.6337	24	1	0	1020	0	8	7
E-J	-21.5553	-0.4718	-217.53	-239.5571	104	4	9	9571	4	15	15
F-J	-14.2022	-24.8058	-28.1302	-67.1382	23	0	0	1054	0	8	7
G-H	-65.2533	49.6567	-560.764	-576.3606	181	17	10	21178	0	53	46
G-I	-16.8723	-13.0119	-29.7043	-59.5886	29	2	0	1400	6	17	18
H-I	-22.6756	0.0	-85.9774	-108.653	41	8	5	3288	0	8	5
H-J	0.0	0.0	-0.0411	-0.0411	2	0	0	5	0	0	1
I-J	-75.0951	59.7916	-580.183	-595.4866	185	11	10	21377	0	54	46
I-K	0.0	0.0	-0.2154	-0.2154	9	0	0	75	0	3	2
I-L	0.0	-9.966	-11.4452	-21.4112	21	4	1	804	1	7	5
K-L	-82.1677	38.9409	-565.677	-608.9039	182	12	10	21065	0	55	48

Interface residues

• A-B: ALA123A, ALA123B, ALA128A, ALA128B, ALA211B, ALA33A, ALA33B, ALA81A, ALA81B, ALA86A, ALA86B, ARG119A, ARG119B, ARG172A, ARG172B, ARG179A, ARG179B, ARG182A, ARG182B, ARG183A, ARG183B, ARG34A, ARG34B, ARG52A, ARG52B, ARG91A, ARG91B, ARG95A, ARG95B, ASP121A, ASP121B, ASP164A, ASP164B, ASP174A, ASP174B, ASP31A, ASP31B, CYS210A, CYS210B, GLN170A, GLN170B, GLN87A, GLN87B, GLU171A, GLU171B, GLU202A, GLU202B, GLU53A, GLU53B, GLU83A, GLU83B, GLU84A, GLU84B, GLY122A, GLY122B, GLY169A, GLY169B, GLY178A, GLY178B, GLY214A, GLY214B, GLY30A, GLY30B, GLY72A, GLY72B, GLY74A, GLY74B, GLY75A, GLY75B, GLY89A, GLY89B, HIS126A, HIS126B, HIS12A, HIS12B, HIS51A, HIS51B, ILE224A, ILE224B, ILE225A, ILE225B, ILE73A, ILE73B, ILE80A, ILE80B, LEU120A, LEU120B, LEU125A, LEU125B, LEU13A, LEU13B, LEU215A, LEU215B, LEU85A, LEU85B, LEU88A, LEU88B, PHE11A, PHE11B, PHE127A, PHE127B, PHE132A, PHE132B, PHE166A, PHE166B, PHE176A, PHE176B, PHE184A, PHE184B, PHE199A, PHE199B, PHE93A, PHE93B, PRO129A, PRO129B, PRO168A, PRO168B, PRO29A, PRO29B, PRO32A, PRO32B, PRO76A, PRO76B, SER124A, SER124B, SER162A, SER162B, SER163A, SER163B, SER212A, SER212B, SER213A, SER213B, SER70A, SER70B, SER77A, SER77B, SER79A, SER79B, THR165A, THR165B, THR175A, THR175B, THR177A, THR177B, THR205A, THR205B, THR208A, THR208B, THR71A, THR71B, THR78A, THR78B, THR98A, THR98B, TYR167A, TYR167B, TYR173A, TYR173B, TYR54A, TYR54B, VAL10A, VAL10B, VAL180A, VAL180B, VAL181A, VAL181B, VAL82A, VAL82B, VAL90A, VAL90B
• A-J: ALA18J, ARG58J, ASN21J, ASN44J, ASP19J, ASP234A, GLU60J, HIS235A, ILE232A, LYS230A, PRO233A
• A-L: ALA146L, ALA147L, ALA148L, ALA153L, ALA33A, ALA39A, ALA49A, ARG244L, ARG254L, ARG58A, ASN44A, ASP62L, GLN149L, GLN36A, GLU150L, GLU251L, GLU40A, GLY152L, LEU48A, LYS247L, LYS255L, PHE47A, PRO45A, SER151L, SER50A, TYR57A, VAL248L, VAL46A
• B-J: GLU17J, THR9B
• B-L: ALA49B, ASN44L, ASP43L, GLN36B, GLN36L, GLU40B, GLU40L, GLU60L, GLY63L, HIS51B, LEU48B, PHE47B, PRO45L, SER50B, THR55B, TYR57B, TYR57L, VAL46B, VAL46L
• C-D: ALA123C, ALA123D, ALA128C, ALA128D, ALA211C, ALA33C, ALA33D, ALA81C, ALA81D, ALA86C, ALA86D, ARG119C, ARG119D, ARG172C, ARG172D, ARG179C, ARG179D, ARG182C, ARG182D, ARG183C, ARG183D, ARG34C, ARG34D, ARG52C, ARG52D, ARG91C, ARG91D, ARG95C, ARG95D, ASP121C, ASP121D, ASP164C, ASP164D, ASP174C, ASP174D, ASP31C, ASP31D, CYS210C, CYS210D, GLN170C, GLN170D, GLN87C, GLN87D, GLU171C, GLU171D, GLU202C, GLU202D, GLU53C, GLU53D, GLU83C, GLU83D, GLU84C, GLU84D, GLY122C, GLY122D, GLY169C, GLY169D, GLY178C, GLY178D, GLY214C, GLY214D, GLY30C, GLY30D, GLY72C, GLY72D, GLY74C, GLY74D, GLY75C, GLY75D, GLY89C, GLY89D, HIS126C, HIS126D, HIS12C, HIS12D, HIS51C, HIS51D, ILE224C, ILE224D, ILE225C, ILE225D, ILE73C, ILE73D, ILE80C, ILE80D, LEU120C, LEU120D, LEU125C, LEU125D, LEU13C, LEU13D, LEU215C, LEU215D, LEU85C, LEU85D, LEU88C, LEU88D, PHE11C, PHE11D, PHE127C, PHE127D, PHE132C, PHE132D, PHE166C, PHE166D, PHE176C, PHE176D, PHE184C, PHE184D, PHE199C, PHE199D, PHE93C, PHE93D, PRO129C, PRO129D, PRO168C, PRO168D, PRO29C, PRO29D, PRO32C, PRO32D, PRO76C, PRO76D, SER124C, SER124D, SER162C, SER162D, SER163C, SER163D, SER212C, SER212D, SER213C, SER213D, SER70C, SER70D, SER77C, SER77D, SER79C, SER79D, THR165C, THR165D, THR175C, THR175D, THR177C, THR177D, THR205C, THR205D, THR208C, THR208D, THR71C, THR71D, THR78C, THR78D, THR9D, TYR167C, TYR167D, TYR173C, TYR173D, TYR54C, TYR54D, VAL10C, VAL10D, VAL180C, VAL180D, VAL181C, VAL181D, VAL82C, VAL82D, VAL90C, VAL90D
• C-F: ARG179C, ARG182C, ARG182F, ARG183C, ARG183F, ASP193F, GLN185C, GLN185F, GLN192F, GLU131F, GLU171F, GLU190F, GLY186F, GLY195F, HIS126C, LEU125C, LYS189F, PHE184F, SER187F, THR177C, TRP191F, VAL180C, VAL180F, VAL181C, VAL181F
• C-I: ALA128C, ALA128I, ALA134C, ALA134I, ALA141C, ALA141I, ALA143C, ALA143I, ALA146C, ALA146I, ALA161C, ALA161I, ALA204C, ALA204I, ALA211C, ALA211I, ARG119C, ARG119I, ARG183C, ARG183I, ASP121C, ASP121I, ASP137C, ASP137I, ASP139C, ASP139I, ASP193C, ASP193I, CYS210I, GLN149C, GLN149I, GLN192C, GLU131C, GLU131I, GLU190C, GLU190I, GLY116C, GLY116I, GLY158C, GLY158I, GLY195C, GLY195I, GLY214C, GLY214I, LEU120C, LEU120I, LEU125C, LEU125I, LEU197C, LEU197I, LEU207C, LEU207I, LYS145C, LYS145I, PHE127C, PHE127I, PHE132C, PHE132I, PHE138C, PHE138I, PHE184C, PHE184I, PRO129C, PRO129I, PRO133C, PRO133I, PRO136C, PRO136I, SER117C, SER117I, SER124I, SER162C, SER162I, SER187C, SER187I, SER212C, SER212I, SER213C, SER213I, THR114C, THR114I, THR115C, THR115I, THR142C, THR142I, THR160C, THR160I, THR208C, THR208I, TRP191C, TRP191I, VAL113C, VAL113I, VAL118C, VAL118I, VAL135C, VAL135I, VAL140C, VAL140I, VAL159C, VAL159I, VAL196C, VAL196I
• C-J: ARG179J, ARG182C, ARG182J, ARG183C, ARG183J, ASP193C, GLN185C, GLN185J, GLN192C, GLU131C, GLU171C, GLU190C, GLY186C, GLY195C, HIS126J, LYS189C, PHE184C, SER187C, THR177J, TRP191C, VAL180J, VAL181C, VAL181J
• C-K: ARG91C, GLN87C, GLU83C, LYS189K, LYS230K, LYS8C, PRO104K
• D-E: ARG179E, ARG182D, ARG182E, ARG183D, ARG183E, ASP193D, GLN185D, GLN185E, GLN192D, GLU131D, GLU190D, GLY186D, GLY195D, HIS126E, LEU125E, LYS189D, PHE184D, SER187D, THR177E, TRP191D, VAL180E, VAL181D, VAL181E
• D-F: ALA128D, ALA128F, ALA134D, ALA134F, ALA141D, ALA141F, ALA143D, ALA143F, ALA146D, ALA146F, ALA161D, ALA161F, ALA204D, ALA204F, ALA211D, ALA211F, ARG119D, ARG119F, ARG183D, ARG183F, ASP121D, ASP121F, ASP137D, ASP137F, ASP139D, ASP139F, ASP193D, ASP193F, CYS210D, GLN149D, GLN149F, GLN192F, GLU131D, GLU131F, GLU190D, GLU190F, GLY116D, GLY116F, GLY158D, GLY158F, GLY195D, GLY195F, GLY214D, GLY214F, LEU120D, LEU120F, LEU125D, LEU125F, LEU197D, LEU197F, LEU207D, LEU207F, LEU215D, LYS145D, LYS145F, PHE127D, PHE127F, PHE132D, PHE132F, PHE138D, PHE138F, PHE184D, PHE184F, PRO129D, PRO129F, PRO133D, PRO133F, PRO136D, PRO136F, SER117D, SER117F, SER124F, SER162D, SER162F, SER187D, SER187F, SER212D, SER212F, SER213D, SER213F, THR114D, THR114F, THR115D, THR115F, THR142D, THR142F, THR160D, THR160F, THR208D, THR208F, TRP191D, TRP191F, VAL113D, VAL113F, VAL118D, VAL118F, VAL135D, VAL135F, VAL140D, VAL140F, VAL159D, VAL159F, VAL196D, VAL196F
• D-I: ARG179D, ARG182D, ARG182I, ARG183D, ARG183I, ASP193I, GLN185D, GLN185I, GLN192I, GLU131I, GLU190I, GLY186I, GLY195I, HIS126D, LEU125D, LYS189I, PHE184I, SER187I, THR177D, TRP191I, VAL180D, VAL181D, VAL181I
• D-K: ARG172D, ARG179D, ARG227D, ASP174D, ASP234K, GLN229K, GLU171D, GLU231K, GLY178D, ILE232K, LYS189D, LYS230K, PHE176D, THR175D, THR177D, TYR173D
• E-F: ALA123E, ALA123F, ALA128E, ALA128F, ALA211E, ALA211F, ALA33E, ALA33F, ALA81E, ALA81F, ALA86E, ALA86F, ARG119E, ARG119F, ARG172E, ARG172F, ARG179E, ARG179F, ARG182E, ARG182F, ARG183E, ARG183F, ARG34E, ARG34F, ARG52E, ARG52F, ARG91E, ARG91F, ARG95E, ARG95F, ASP121E, ASP121F, ASP164E, ASP164F, ASP174E, ASP174F, ASP31E, ASP31F, CYS210E, CYS210F, GLN170E, GLN170F, GLN87E, GLN87F, GLU171E, GLU171F, GLU200E, GLU202E, GLU202F, GLU242E, GLU53E, GLU53F, GLU83E, GLU83F, GLU84E, GLU84F, GLY122E, GLY122F, GLY169E, GLY169F, GLY178E, GLY178F, GLY214E, GLY214F, GLY30E, GLY30F, GLY72E, GLY72F, GLY74E, GLY74F, GLY75E, GLY75F, GLY89E, GLY89F, GLY97E, GLY97F, HIS126E, HIS126F, HIS12E, HIS12F, HIS51E, HIS51F, ILE224E, ILE224F, ILE225E, ILE225F, ILE73E, ILE73F, ILE80E, ILE80F, LEU120E, LEU120F, LEU125E, LEU125F, LEU13E, LEU13F, LEU215E, LEU215F, LEU238E, LEU238F, LEU85E, LEU85F, LEU88E, LEU88F, PHE11E, PHE11F, PHE127E, PHE127F, PHE132E, PHE132F, PHE166E, PHE166F, PHE176E, PHE176F, PHE184E, PHE184F, PHE199E, PHE199F, PHE93E, PHE93F, PRO129E, PRO129F, PRO168E, PRO168F, PRO29E, PRO29F, PRO32E, PRO32F, PRO76E, PRO76F, SER124E, SER124F, SER162E, SER162F, SER163E, SER163F, SER212E, SER212F, SER213E, SER213F, SER50E, SER50F, SER70E, SER70F, SER77E, SER77F, SER79E, SER79F, THR165E, THR165F, THR175E, THR175F, THR177E, THR177F, THR205E, THR205F, THR208E, THR208F, THR55E, THR71E, THR71F, THR78E, THR78F, THR98E, THR98F, THR9F, TYR167E, TYR167F, TYR173E, TYR173F, TYR54E, TYR54F, VAL10E, VAL10F, VAL180E, VAL180F, VAL181E, VAL181F, VAL82E, VAL82F, VAL90E, VAL90F, VAL96F
• E-I: ARG179I, ARG182E, ARG182I, ARG183E, ARG183I, ASP193E, GLN185E, GLN185I, GLN192E, GLU131E, GLU190E, GLY186E, GLY195E, HIS126I, LEU125I, LYS189E, PHE184E, SER187E, THR177I, TRP191E, VAL180E, VAL180I, VAL181E, VAL181I
• E-J: ALA128E, ALA128J, ALA134E, ALA134J, ALA141E, ALA141J, ALA143E, ALA143J, ALA146E, ALA146J, ALA161E, ALA161J, ALA204E, ALA204J, ALA211E, ALA211J, ARG119E, ARG119J, ARG183E, ARG183J, ASP121E, ASP121J, ASP137E, ASP137J, ASP139E, ASP139J, ASP193E, ASP193J, CYS210E, GLN149J, GLN192E, GLU131E, GLU131J, GLU190E, GLU190J, GLY116E, GLY116J, GLY158E, GLY158J, GLY195E, GLY195J, GLY214E, GLY214J, LEU120E, LEU120J, LEU125E, LEU125J, LEU197E, LEU197J, LEU207E, LEU207J, LYS145E, LYS145J, LYS216E, PHE127E, PHE127J, PHE132E, PHE132J, PHE138E, PHE138J, PHE184E, PHE184J, PRO129E, PRO129J, PRO133E, PRO133J, PRO136E, PRO136J, SER117E, SER117J, SER124E, SER124J, SER162E, SER162J, SER187E, SER187J, SER212E, SER212J, SER213E, SER213J, THR114E, THR114J, THR115E, THR115J, THR142E, THR142J, THR160E, THR160J, THR208E, THR208J, TRP191E, TRP191J, VAL113E, VAL113J, VAL118E, VAL118J, VAL135E, VAL135J, VAL140E, VAL140J, VAL159E, VAL159J, VAL196E, VAL196J
• F-J: ARG179F, ARG182F, ARG182J, ARG183F, ARG183J, ASP193J, GLN185F, GLN185J, GLN192J, GLU131J, GLU190J, GLY186J, GLY195J, HIS126F, LEU125F, LYS189J, PHE184J, SER187J, THR177F, TRP191J, VAL180F, VAL181F, VAL181J
• G-H: ALA123G, ALA123H, ALA128G, ALA128H, ALA211G, ALA211H, ALA33G, ALA33H, ALA81G, ALA81H, ALA86G, ALA86H, ARG119G, ARG119H, ARG172G, ARG172H, ARG179G, ARG179H, ARG182G, ARG182H, ARG183G, ARG183H, ARG34G, ARG34H, ARG52G, ARG52H, ARG91G, ARG91H, ARG95G, ARG95H, ASP121G, ASP121H, ASP164G, ASP164H, ASP174G, ASP174H, ASP31G, ASP31H, CYS210G, CYS210H, GLN170G, GLN170H, GLN87G, GLN87H, GLU171G, GLU171H, GLU202G, GLU202H, GLU242G, GLU53G, GLU53H, GLU83G, GLU83H, GLU84G, GLU84H, GLY122G, GLY122H, GLY169G, GLY169H, GLY178G, GLY178H, GLY214G, GLY214H, GLY30G, GLY30H, GLY72G, GLY72H, GLY74G, GLY74H, GLY75G, GLY75H, GLY89G, GLY89H, GLY97G, HIS126G, HIS126H, HIS12G, HIS12H, HIS51G, HIS51H, ILE224G, ILE224H, ILE225G, ILE225H, ILE232H, ILE73G, ILE73H, ILE80G, ILE80H, LEU120G, LEU120H, LEU125G, LEU125H, LEU13G, LEU13H, LEU215G, LEU215H, LEU238G, LEU85G, LEU85H, LEU88G, LEU88H, PHE11G, PHE11H, PHE127G, PHE127H, PHE132G, PHE132H, PHE166G, PHE166H, PHE176G, PHE176H, PHE184G, PHE184H, PHE199G, PHE199H, PHE93G, PHE93H, PRO129G, PRO129H, PRO168G, PRO168H, PRO233G, PRO29G, PRO29H, PRO32G, PRO32H, PRO76G, PRO76H, SER124G, SER124H, SER162G, SER162H, SER163G, SER163H, SER212G, SER212H, SER213G, SER213H, SER50G, SER50H, SER70G, SER70H, SER77G, SER77H, SER79G, SER79H, THR165G, THR165H, THR175G, THR175H, THR177G, THR177H, THR205G, THR205H, THR208G, THR208H, THR71G, THR71H, THR78G, THR78H, THR98G, THR98H, THR99G, THR9G, TYR167G, TYR167H, TYR173G, TYR173H, TYR54G, TYR54H, VAL10G, VAL10H, VAL180G, VAL180H, VAL181G, VAL181H, VAL82G, VAL82H, VAL90G, VAL90H
• G-I: ALA33G, ARG254I, ARG34G, ASN21I, ASN44I, ASP31G, ASP43I, ASP62I, GLN36G, GLN64I, GLU242G, GLU251I, GLU40G, GLU60I, GLY63I, HIS235G, LEU257I, LEU41I, LEU61I, LYS239G, LYS247I, LYS37G, PHE47G, PRO32G, PRO45I, SER65I, TYR57G, VAL250I, VAL35G
• H-I: ALA39I, ALA49H, ALA49I, ALA59I, ARG52H, ARG58H, ARG58I, ASN21H, ASN21I, ASN44I, ASP19H, ASP43I, GLN36H, GLN36I, GLU40H, GLU40I, GLU60I, GLY14H, HIS12H, HIS51H, LEU13H, LEU48H, LEU48I, LYS37I, PHE47H, PHE47I, PRO45I, SER50H, SER50I, THR16H, THR55H, THR55I, THR9H, TYR54H, TYR57H, TYR57I, VAL15H, VAL35I, VAL46H, VAL46I, VAL56H
• H-J: ASN44H, GLN36J
• I-J: ALA123I, ALA123J, ALA128I, ALA128J, ALA211I, ALA211J, ALA33I, ALA33J, ALA81I, ALA81J, ALA86I, ALA86J, ARG119I, ARG119J, ARG172I, ARG172J, ARG179I, ARG179J, ARG182I, ARG182J, ARG183I, ARG183J, ARG34I, ARG34J, ARG52I, ARG52J, ARG91I, ARG91J, ARG95I, ARG95J, ASP121I, ASP121J, ASP164I, ASP164J, ASP174I, ASP174J, ASP31I, ASP31J, CYS210I, CYS210J, GLN170I, GLN170J, GLN87I, GLN87J, GLU171I, GLU171J, GLU202I, GLU202J, GLU242I, GLU242J, GLU53I, GLU53J, GLU83I, GLU83J, GLU84I, GLU84J, GLY122I, GLY122J, GLY169I, GLY169J, GLY178I, GLY178J, GLY214I, GLY214J, GLY30I, GLY30J, GLY72I, GLY72J, GLY74I, GLY74J, GLY75I, GLY75J, GLY89I, GLY89J, GLY97I, GLY97J, HIS126I, HIS126J, HIS12I, HIS12J, HIS51I, HIS51J, ILE224I, ILE224J, ILE225I, ILE225J, ILE73I, ILE73J, ILE80I, ILE80J, LEU120I, LEU120J, LEU125I, LEU125J, LEU13I, LEU13J, LEU215I, LEU215J, LEU238I, LEU238J, LEU85I, LEU85J, LEU88I, LEU88J, LYS8I, PHE11I, PHE11J, PHE127I, PHE127J, PHE132I, PHE132J, PHE166I, PHE166J, PHE176I, PHE176J, PHE184I, PHE184J, PHE199I, PHE199J, PHE93I, PHE93J, PRO129I, PRO129J, PRO168I, PRO168J, PRO233I, PRO29I, PRO29J, PRO32I, PRO32J, PRO76I, PRO76J, SER124I, SER124J, SER162I, SER162J, SER163I, SER163J, SER212I, SER212J, SER213I, SER213J, SER50I, SER50J, SER70I, SER70J, SER77I, SER77J, SER79I, SER79J, THR165I, THR165J, THR175I, THR175J, THR177I, THR177J, THR205I, THR205J, THR208J, THR55J, THR71I, THR71J, THR78I, THR78J, THR98I, THR98J, THR99I, THR9I, TYR167I, TYR167J, TYR173I, TYR173J, TYR54I, TYR54J, VAL10I, VAL10J, VAL180I, VAL180J, VAL181I, VAL181J, VAL82I, VAL82J, VAL90I, VAL90J, VAL96I
• I-K: ASP174K, GLN229I, GLU231I, GLY178K, LYS189I, LYS230I, PHE176K, PRO104I, THR228I
• I-L: ALA18L, ALA23L, ALA86L, ARG227I, ARG91L, ASN21L, ASP174I, GLN229I, GLN87L, GLU17L, GLU231I, GLY22L, GLY89L, LEU20L, LEU85L, LEU88L, LYS230I, THR228I, THR24L, TYR173I, VAL90L
• K-L: ALA123K, ALA123L, ALA128K, ALA128L, ALA211K, ALA211L, ALA33K, ALA33L, ALA81K, ALA81L, ALA86K, ALA86L, ARG119K, ARG119L, ARG172K, ARG172L, ARG179K, ARG179L, ARG182K, ARG182L, ARG183K, ARG183L, ARG34K, ARG34L, ARG52K, ARG52L, ARG91K, ARG91L, ARG95K, ARG95L, ASP121K, ASP121L, ASP164K, ASP164L, ASP174K, ASP174L, ASP31K, ASP31L, CYS210K, CYS210L, GLN170K, GLN170L, GLN87K, GLN87L, GLU171K, GLU171L, GLU202K, GLU202L, GLU242K, GLU242L, GLU53K, GLU53L, GLU83K, GLU83L, GLU84K, GLU84L, GLY122K, GLY122L, GLY169K, GLY169L, GLY178K, GLY178L, GLY214K, GLY214L, GLY30K, GLY30L, GLY72K, GLY72L, GLY74K, GLY74L, GLY75K, GLY75L, GLY89K, GLY89L, GLY97K, GLY97L, HIS126K, HIS126L, HIS12K, HIS12L, HIS51K, HIS51L, ILE224K, ILE224L, ILE225K, ILE225L, ILE232K, ILE73K, ILE73L, ILE80K, ILE80L, LEU120K, LEU120L, LEU125K, LEU125L, LEU13K, LEU13L, LEU215K, LEU215L, LEU238K, LEU238L, LEU85K, LEU85L, LEU88K, LEU88L, LYS8K, PHE11K, PHE11L, PHE127K, PHE127L, PHE132L, PHE166K, PHE166L, PHE176K, PHE176L, PHE184K, PHE184L, PHE199K, PHE199L, PHE93K, PHE93L, PRO129K, PRO129L, PRO168K, PRO168L, PRO233K, PRO29K, PRO29L, PRO32K, PRO32L, PRO76K, PRO76L, SER124K, SER124L, SER162K, SER162L, SER163K, SER163L, SER212K, SER212L, SER213K, SER213L, SER50K, SER50L, SER70K, SER70L, SER77K, SER77L, SER79K, SER79L, THR165K, THR165L, THR175K, THR175L, THR177K, THR177L, THR205K, THR205L, THR208L, THR71K, THR71L, THR78K, THR78L, THR98K, THR98L, THR9K, TYR167K, TYR167L, TYR173K, TYR173L, TYR54K, TYR54L, VAL10K, VAL10L, VAL180K, VAL180L, VAL181K, VAL181L, VAL82K, VAL82L, VAL90K, VAL90L