3PK7

crystal structure of d-mannonate dehydratase from chromohalobacter salexigens with mg and glycerol bound in the active site

• Total interactions analyzed: 28
• Total true interactions: 14
• Strongest Interaction:
  • Chains: A-B
  • Int. Res.: 223
  • Norm. En. per Res.: -4.5316
• Hub Node: A(4)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-91.4631	-174.592	-744.484	-1010.5391	223	23	23	27737	20	68	94
A-C	-14.4645	-13.7848	-3.8806	-32.1299	20	2	0	235	2	13	12
A-F	-56.8803	-34.2338	-225.24	-316.3542	109	10	0	9158	4	55	58
A-H	0.0	0.0	-1.4607	-1.4607	7	0	0	106	0	3	4
B-F	-71.841	0.3322	-331.752	-403.2608	126	23	3	14028	5	37	49
B-G	-71.6416	-30.0078	-220.071	-321.7204	110	11	0	9153	4	55	58
B-H	-6.8554	31.603	-83.8197	-59.0721	47	3	0	3530	0	37	37
C-D	-74.6763	-151.5059	-714.157	-940.3391	221	21	23	27543	18	68	95
C-E	-72.3143	-34.0631	-228.098	-334.4755	110	12	0	9351	4	56	60
C-H	-77.2905	-8.7751	-334.454	-420.5196	127	23	3	14338	4	36	48
D-H	-64.4267	-38.752	-232.059	-335.2378	111	12	0	9484	4	55	58
E-H	-94.262	-180.0388	-725.118	-999.4188	223	27	23	27553	22	68	94
F-G	-97.059	-157.5976	-735.86	-990.5165	225	28	23	27926	21	68	94
F-H	0.0	5.523	-8.6495	-3.1265	16	0	0	567	0	12	20

Interface residues

• A-B: ALA180A, ALA180B, ALA244A, ALA244B, ALA390A, ALA390B, ALA44A, ALA44B, ALA46A, ALA46B, ALA47A, ALA47B, ALA56A, ALA56B, ALA76A, ALA76B, ALA87A, ALA87B, ARG149A, ARG17A, ARG17B, ARG217A, ARG217B, ARG274A, ARG274B, ARG286A, ARG286B, ARG389A, ARG389B, ARG396A, ARG396B, ARG41A, ARG41B, ARG60A, ARG60B, ARG64A, ARG64B, ARG74A, ARG74B, ARG79A, ARG79B, ARG80A, ARG80B, ASN18A, ASN18B, ASN246A, ASN246B, ASN268A, ASN268B, ASN279A, ASN279B, ASN395A, ASN395B, ASN39A, ASN39B, ASP213A, ASP213B, ASP240A, ASP240B, ASP272A, ASP272B, ASP319A, ASP319B, ASP399A, ASP50A, ASP50B, ASP61A, ASP61B, ASP67A, ASP67B, CYS273A, CYS273B, GLN247A, GLN247B, GLN278A, GLN278B, GLN70A, GLN70B, GLU181A, GLU181B, GLU239A, GLU239B, GLU245A, GLU245B, GLU248A, GLU248B, GLU265A, GLU265B, GLU275A, GLU275B, GLU388A, GLU388B, GLU42A, GLU42B, GLU51A, GLU51B, GLU66A, GLU66B, GLY264A, GLY264B, GLY400A, GLY400B, GLY40A, GLY40B, GLY75A, GLY75B, GLY81A, GLY81B, HIS215A, HIS215B, HIS216A, HIS216B, HIS271A, HIS271B, HIS291A, HIS291B, HIS315A, HIS315B, HIS404A, HIS404B, HIS52A, HIS52B, ILE270A, ILE270B, ILE58A, ILE58B, ILE88A, ILE88B, LEU178A, LEU178B, LEU320A, LEU320B, LEU38A, LEU38B, LEU392A, LEU392B, LEU397A, LEU397B, LEU402A, LEU402B, LEU49A, LEU49B, LEU57A, LEU57B, LEU72A, LEU72B, MET287A, MET287B, MET43A, MET43B, MET85A, MET85B, PHE267A, PHE267B, PRO179A, PRO179B, PRO243A, PRO243B, PRO288A, PRO288B, PRO317A, PRO317B, PRO393A, PRO393B, PRO55A, PRO55B, PRO82A, PRO82B, SER177A, SER177B, SER249A, SER249B, SER269A, SER269B, SER391A, SER391B, THR37A, THR37B, THR401A, THR401B, THR68A, THR68B, THR84A, THR84B, THR86A, THR86B, TRP281A, TRP281B, TRP403A, TRP403B, TRP405A, TRP405B, TRP69A, TRP69B, TRP78A, TRP78B, TYR161A, TYR387A, TYR387B, TYR48A, TYR48B, TYR71A, TYR71B, TYR73A, TYR73B, TYR77A, TYR77B, VAL20A, VAL20B, VAL242A, VAL242B, VAL266A, VAL266B, VAL394A, VAL394B, VAL45A, VAL45B, VAL53A, VAL53B, VAL54A, VAL54B, VAL83A, VAL83B
• A-C: ALA390A, ARG17A, ARG6C, ASP175A, CYS14A, GLU172A, GLU27C, GLU349A, GLU388A, GLY16A, GLY59C, ILE58C, LEU3C, LYS4C, PRO15A, PRO386A, SER28C, THR347A, TYR171A, TYR385A
• A-F: ALA223A, ALA224A, ALA229A, ALA244A, ARG116F, ARG118F, ARG146F, ARG201F, ARG217A, ARG225A, ARG251A, ARG251F, ARG254F, ARG311F, ARG396A, ASN191A, ASN246A, ASN279F, ASN337F, ASP206F, ASP207F, ASP283F, ASP332F, ASP399A, GLN247A, GLN278F, GLN280F, GLU117F, GLU187A, GLU222A, GLU231F, GLU245A, GLU248A, GLU255A, GLU255F, GLU398A, GLY156A, GLY205F, GLY227A, GLY227F, GLY339F, GLY400A, HIS192A, HIS209F, HIS216A, HIS234F, HIS256A, HIS256F, HIS309F, HIS364F, HIS404A, ILE221A, ILE253A, ILE253F, ILE277F, ILE282F, LEU190A, LEU208F, LEU218A, LEU226A, LEU235F, LEU250A, LEU252A, LEU252F, LEU261F, LEU304F, LEU307F, LEU397A, LEU402A, LYS114F, LYS188A, LYS195A, LYS228A, LYS228F, MET120F, PHE236F, PHE338F, PRO155A, PRO194A, PRO220A, PRO232F, PRO243A, PRO260F, PRO336F, SER115F, SER185A, SER249A, SER306F, THR186A, THR219A, THR257A, THR257F, THR258F, THR259F, THR333F, THR401A, TRP237F, TRP281A, TRP281F, TRP334F, TRP403A, TYR233F, TYR284F, TYR308F, VAL119F, VAL210F, VAL242A, VAL310F, VAL335F
• A-H: ARG359H, ARG389A, GLU369H, LEU178A, LEU366H, LYS114H, SER177A
• B-F: ALA100B, ALA100F, ALA102B, ALA102F, ALA103B, ALA103F, ALA302B, ALA302F, ALA62B, ALA62F, ARG116B, ARG116F, ARG274B, ARG274F, ARG299B, ARG299F, ARG300B, ARG300F, ARG60B, ARG60F, ARG64B, ARG64F, ARG74B, ARG74F, ARG79B, ARG79F, ASN279B, ASN279F, ASN337B, ASN337F, ASP303B, ASP303F, ASP61B, ASP61F, ASP67B, ASP67F, GLN109B, GLN109F, GLN278B, GLN278F, GLN280B, GLN280F, GLN70B, GLN70F, GLU117B, GLU117F, GLU275B, GLU275F, GLU369F, GLU66B, GLU66F, GLY104B, GLY104F, GLY112B, GLY112F, GLY113B, GLY113F, GLY63B, GLY63F, HIS271B, HIS271F, HIS309B, HIS309F, ILE270B, ILE270F, ILE277B, ILE277F, ILE295B, ILE295F, ILE65B, ILE65F, ILE98B, ILE98F, LEU107B, LEU107F, LEU110B, LEU110F, LEU111B, LEU111F, LEU304B, LEU304F, LEU307B, LEU307F, LEU3B, LEU3F, LEU95B, LEU95F, LYS101B, LYS101F, LYS114B, LYS114F, LYS4F, LYS99B, LYS99F, MET105B, MET105F, PRO106B, PRO106F, PRO336B, PRO336F, SER115B, SER115F, SER269F, SER306B, SER306F, THR296B, THR296F, THR333B, THR333F, THR68B, THR68F, TRP334B, TRP334F, TRP69B, TRP69F, TRP96B, TRP96F, TYR108B, TYR108F, TYR308B, TYR308F, TYR73B, VAL301B, VAL301F, VAL335B, VAL335F
• B-G: ALA223G, ALA224G, ALA229G, ALA244G, ARG116B, ARG118B, ARG146B, ARG201B, ARG217G, ARG225G, ARG251B, ARG251G, ARG254B, ARG311B, ARG396G, ASN191G, ASN246G, ASN279B, ASN337B, ASP206B, ASP207B, ASP283B, ASP332B, ASP399G, GLN247G, GLN278B, GLN280B, GLU117B, GLU187G, GLU222G, GLU231B, GLU245G, GLU248G, GLU255B, GLU255G, GLU398G, GLY156G, GLY205B, GLY227B, GLY227G, GLY339B, GLY400G, HIS192G, HIS209B, HIS216G, HIS234B, HIS256B, HIS256G, HIS309B, HIS364B, HIS404G, ILE221G, ILE253B, ILE253G, ILE277B, ILE282B, ILE340B, LEU190G, LEU208B, LEU218G, LEU226G, LEU235B, LEU250G, LEU252B, LEU252G, LEU261B, LEU304B, LEU307B, LEU397G, LEU402G, LYS114B, LYS188G, LYS195G, LYS228B, LYS228G, MET120B, PHE236B, PHE338B, PRO155G, PRO194G, PRO220G, PRO232B, PRO243G, PRO260B, PRO336B, SER115B, SER185G, SER249G, SER306B, THR186G, THR219G, THR257B, THR257G, THR258B, THR259B, THR333B, THR401G, TRP237B, TRP281B, TRP281G, TRP334B, TRP403G, TYR233B, TYR284B, TYR308B, VAL119B, VAL210B, VAL242G, VAL310B, VAL335B
• B-H: ALA56B, ALA8B, ARG139H, ARG146H, ARG359H, ARG60B, ARG64B, ARG6B, ASP348H, ASP351H, ASP357H, ASP362H, ASP7B, GLU142H, GLU27B, GLU361H, GLY144H, GLY29B, GLY363H, GLY59B, HIS140H, HIS31B, HIS343H, HIS346H, HIS356H, HIS364H, ILE58B, ILE5B, LEU143H, LEU366H, LEU3B, LEU57B, LYS4B, PHE360H, PHE365H, PRO345H, PRO355H, PRO55B, SER28B, THR26B, THR30B, TYR145H, TYR358H, TYR9B, VAL141H, VAL25B, VAL54B
• C-D: ALA180C, ALA180D, ALA244C, ALA244D, ALA390C, ALA390D, ALA44C, ALA44D, ALA46C, ALA46D, ALA47C, ALA47D, ALA56C, ALA56D, ALA76C, ALA76D, ALA87C, ALA87D, ARG149C, ARG17C, ARG17D, ARG217C, ARG217D, ARG274C, ARG274D, ARG389C, ARG389D, ARG396C, ARG396D, ARG41C, ARG41D, ARG60C, ARG60D, ARG64C, ARG64D, ARG74C, ARG74D, ARG79C, ARG79D, ARG80C, ARG80D, ASN18C, ASN18D, ASN246C, ASN246D, ASN268C, ASN268D, ASN279C, ASN279D, ASN395C, ASN395D, ASN39C, ASN39D, ASP213C, ASP213D, ASP240C, ASP240D, ASP272C, ASP272D, ASP319C, ASP319D, ASP399C, ASP399D, ASP50C, ASP50D, ASP61D, ASP67C, ASP67D, CYS273C, CYS273D, GLN247C, GLN247D, GLN278C, GLN278D, GLN70C, GLN70D, GLU181C, GLU181D, GLU239C, GLU239D, GLU245C, GLU245D, GLU248C, GLU248D, GLU265C, GLU265D, GLU275C, GLU275D, GLU388C, GLU388D, GLU42C, GLU42D, GLU51C, GLU51D, GLU66C, GLU66D, GLY264C, GLY264D, GLY400C, GLY400D, GLY40C, GLY40D, GLY75C, GLY75D, GLY81C, GLY81D, HIS215C, HIS215D, HIS216C, HIS216D, HIS271C, HIS271D, HIS291C, HIS291D, HIS315C, HIS315D, HIS404C, HIS404D, HIS52C, HIS52D, ILE270C, ILE270D, ILE58C, ILE58D, ILE88C, ILE88D, LEU178C, LEU178D, LEU320C, LEU320D, LEU38C, LEU38D, LEU392C, LEU392D, LEU397C, LEU397D, LEU402C, LEU402D, LEU49C, LEU49D, LEU57C, LEU57D, LEU72C, LEU72D, MET287C, MET287D, MET43C, MET43D, MET85C, MET85D, PHE267C, PHE267D, PRO179C, PRO179D, PRO243C, PRO243D, PRO288C, PRO288D, PRO317C, PRO317D, PRO393C, PRO393D, PRO55C, PRO55D, PRO82C, PRO82D, SER177C, SER177D, SER249C, SER249D, SER269C, SER269D, SER391C, SER391D, THR37C, THR37D, THR401C, THR401D, THR68C, THR68D, THR84C, THR84D, THR86C, THR86D, TRP281C, TRP281D, TRP403C, TRP403D, TRP405C, TRP405D, TRP69C, TRP69D, TRP78C, TRP78D, TYR161C, TYR387C, TYR387D, TYR48C, TYR48D, TYR71C, TYR71D, TYR73C, TYR73D, TYR77C, TYR77D, VAL20C, VAL20D, VAL242C, VAL242D, VAL266C, VAL266D, VAL394C, VAL394D, VAL45C, VAL45D, VAL53C, VAL53D, VAL54C, VAL54D, VAL83C, VAL83D
• C-E: ALA223E, ALA224E, ALA229E, ALA244E, ARG116C, ARG118C, ARG146C, ARG201C, ARG217E, ARG225E, ARG251C, ARG251E, ARG254C, ARG311C, ARG396E, ASN191E, ASN246E, ASN279C, ASN337C, ASP206C, ASP207C, ASP283C, ASP332C, ASP399E, GLN247E, GLN278C, GLN280C, GLU117C, GLU187E, GLU222E, GLU231C, GLU245E, GLU248E, GLU255C, GLU255E, GLU398E, GLY156E, GLY205C, GLY227C, GLY227E, GLY339C, GLY400E, HIS192E, HIS209C, HIS216E, HIS234C, HIS256C, HIS256E, HIS309C, HIS364C, HIS404E, ILE221E, ILE253C, ILE253E, ILE277C, ILE282C, LEU190E, LEU208C, LEU218E, LEU226E, LEU235C, LEU250E, LEU252C, LEU252E, LEU261C, LEU304C, LEU307C, LEU397E, LEU402E, LYS114C, LYS188E, LYS195E, LYS228C, LYS228E, MET120C, PHE236C, PHE338C, PRO155E, PRO194E, PRO220E, PRO232C, PRO243E, PRO260C, PRO336C, SER115C, SER185E, SER249E, SER306C, THR186E, THR219E, THR257C, THR257E, THR258C, THR259C, THR333C, THR401E, TRP184E, TRP237C, TRP281C, TRP281E, TRP334C, TRP403E, TYR233C, TYR284C, TYR308C, VAL119C, VAL210C, VAL242E, VAL310C, VAL335C
• C-H: ALA100C, ALA100H, ALA102C, ALA102H, ALA103C, ALA103H, ALA302C, ALA302H, ALA62C, ALA62H, ARG116C, ARG116H, ARG118C, ARG118H, ARG274C, ARG274H, ARG299C, ARG299H, ARG300C, ARG300H, ARG60C, ARG60H, ARG64C, ARG64H, ARG74C, ARG74H, ARG79C, ARG79H, ASN279C, ASN279H, ASN337C, ASN337H, ASP303C, ASP303H, ASP61C, ASP61H, ASP67C, ASP67H, GLN109C, GLN109H, GLN278C, GLN278H, GLN280C, GLN280H, GLN70C, GLN70H, GLU117C, GLU117H, GLU275C, GLU275H, GLU66C, GLU66H, GLY104C, GLY104H, GLY112C, GLY112H, GLY113C, GLY113H, GLY63C, GLY63H, HIS271C, HIS271H, HIS309C, HIS309H, ILE270C, ILE270H, ILE277C, ILE277H, ILE295C, ILE295H, ILE65C, ILE65H, ILE98C, ILE98H, LEU107C, LEU107H, LEU110C, LEU110H, LEU111C, LEU111H, LEU304C, LEU304H, LEU307C, LEU307H, LEU3C, LEU3H, LEU95C, LEU95H, LYS101C, LYS101H, LYS114C, LYS114H, LYS99C, LYS99H, MET105C, MET105H, PRO106C, PRO106H, PRO336C, PRO336H, SER115C, SER115H, SER269C, SER269H, SER306C, SER306H, THR296C, THR296H, THR333C, THR333H, THR68C, THR68H, TRP334C, TRP334H, TRP69C, TRP69H, TRP96C, TRP96H, TYR108C, TYR108H, TYR308C, TYR308H, TYR71C, VAL301C, VAL301H, VAL335C, VAL335H
• D-H: ALA223D, ALA224D, ALA229D, ALA244D, ARG116H, ARG118H, ARG146H, ARG201H, ARG217D, ARG225D, ARG251D, ARG251H, ARG254H, ARG311H, ARG396D, ASN191D, ASN246D, ASN279H, ASN337H, ASP206H, ASP207H, ASP283H, ASP332H, ASP399D, GLN247D, GLN278H, GLN280H, GLU117H, GLU187D, GLU222D, GLU231H, GLU245D, GLU248D, GLU255D, GLU255H, GLU398D, GLY156D, GLY205H, GLY227D, GLY227H, GLY339H, GLY400D, HIS192D, HIS209H, HIS216D, HIS234H, HIS256D, HIS256H, HIS309H, HIS364H, HIS404D, ILE221D, ILE253D, ILE253H, ILE277H, ILE282H, LEU190D, LEU208H, LEU218D, LEU226D, LEU235H, LEU250D, LEU252D, LEU252H, LEU261H, LEU304H, LEU307H, LEU397D, LEU402D, LYS114H, LYS188D, LYS195D, LYS228D, LYS228H, MET120H, PHE236H, PHE338H, PRO155D, PRO194D, PRO220D, PRO232H, PRO243D, PRO260H, PRO336H, SER115H, SER185D, SER249D, SER306H, THR186D, THR219D, THR257D, THR257H, THR258H, THR259H, THR333H, THR401D, TRP184D, TRP237H, TRP281D, TRP281H, TRP334H, TRP403D, TYR233H, TYR284H, TYR308H, VAL119H, VAL183D, VAL210H, VAL242D, VAL310H, VAL335H
• E-H: ALA180E, ALA180H, ALA244E, ALA244H, ALA390E, ALA390H, ALA44E, ALA44H, ALA46E, ALA46H, ALA47E, ALA47H, ALA56E, ALA56H, ALA76E, ALA76H, ALA87E, ALA87H, ARG149H, ARG17E, ARG17H, ARG217E, ARG217H, ARG274E, ARG274H, ARG389E, ARG389H, ARG396E, ARG396H, ARG41E, ARG41H, ARG60E, ARG60H, ARG64E, ARG64H, ARG74E, ARG74H, ARG79E, ARG79H, ARG80E, ARG80H, ASN18E, ASN18H, ASN246E, ASN246H, ASN268E, ASN268H, ASN279E, ASN279H, ASN395E, ASN395H, ASN39E, ASN39H, ASP213E, ASP213H, ASP240E, ASP240H, ASP272E, ASP272H, ASP319E, ASP319H, ASP399E, ASP399H, ASP50E, ASP50H, ASP61E, ASP61H, ASP67E, ASP67H, CYS273E, CYS273H, GLN247E, GLN247H, GLN278E, GLN278H, GLN70E, GLN70H, GLU181E, GLU181H, GLU239E, GLU239H, GLU245E, GLU245H, GLU248E, GLU248H, GLU265E, GLU265H, GLU275E, GLU275H, GLU388E, GLU388H, GLU42E, GLU42H, GLU51E, GLU51H, GLU66E, GLU66H, GLY264E, GLY264H, GLY400E, GLY400H, GLY40E, GLY40H, GLY75E, GLY75H, GLY81E, GLY81H, HIS215E, HIS215H, HIS216E, HIS216H, HIS271E, HIS271H, HIS291E, HIS291H, HIS315E, HIS315H, HIS404E, HIS404H, HIS52E, HIS52H, ILE270E, ILE270H, ILE58E, ILE58H, ILE88E, ILE88H, LEU178E, LEU178H, LEU320E, LEU320H, LEU38E, LEU38H, LEU392E, LEU392H, LEU397E, LEU397H, LEU402E, LEU402H, LEU49E, LEU49H, LEU57E, LEU57H, LEU72E, LEU72H, MET287E, MET287H, MET43E, MET43H, MET85E, MET85H, PHE267E, PHE267H, PRO179E, PRO179H, PRO243E, PRO243H, PRO288E, PRO288H, PRO317E, PRO317H, PRO393E, PRO393H, PRO55E, PRO55H, PRO82E, PRO82H, SER177E, SER177H, SER249E, SER249H, SER269E, SER269H, SER391E, SER391H, THR37E, THR37H, THR401E, THR401H, THR68E, THR68H, THR84E, THR84H, THR86E, THR86H, TRP281E, TRP281H, TRP403E, TRP403H, TRP405E, TRP405H, TRP69E, TRP69H, TRP78E, TRP78H, TYR161E, TYR161H, TYR387E, TYR387H, TYR48E, TYR48H, TYR71E, TYR71H, TYR73E, TYR73H, TYR77E, TYR77H, VAL20E, VAL20H, VAL242E, VAL242H, VAL266E, VAL266H, VAL394E, VAL394H, VAL45E, VAL45H, VAL53E, VAL53H, VAL54E, VAL54H, VAL83E, VAL83H
• F-G: ALA180F, ALA180G, ALA244F, ALA244G, ALA390F, ALA390G, ALA44F, ALA44G, ALA46F, ALA46G, ALA47F, ALA47G, ALA56F, ALA56G, ALA76F, ALA76G, ALA87F, ALA87G, ARG149G, ARG17F, ARG17G, ARG217F, ARG217G, ARG274F, ARG274G, ARG286F, ARG286G, ARG389F, ARG389G, ARG396F, ARG396G, ARG41F, ARG41G, ARG60F, ARG60G, ARG64F, ARG64G, ARG74F, ARG74G, ARG79F, ARG79G, ARG80F, ARG80G, ASN18F, ASN18G, ASN246F, ASN246G, ASN268F, ASN268G, ASN279F, ASN279G, ASN395F, ASN395G, ASN39F, ASN39G, ASP213F, ASP213G, ASP240F, ASP240G, ASP272F, ASP272G, ASP319F, ASP319G, ASP399F, ASP399G, ASP50F, ASP50G, ASP61F, ASP61G, ASP67F, ASP67G, CYS273F, CYS273G, GLN247F, GLN247G, GLN278F, GLN278G, GLN70F, GLN70G, GLU181F, GLU181G, GLU239F, GLU239G, GLU245F, GLU245G, GLU248F, GLU248G, GLU265F, GLU265G, GLU275F, GLU275G, GLU388F, GLU388G, GLU42F, GLU42G, GLU51F, GLU51G, GLU66F, GLU66G, GLY264F, GLY264G, GLY400F, GLY400G, GLY40F, GLY40G, GLY59F, GLY75F, GLY75G, GLY81F, GLY81G, HIS215F, HIS215G, HIS216F, HIS216G, HIS271F, HIS271G, HIS291F, HIS291G, HIS315F, HIS315G, HIS404F, HIS404G, HIS52F, HIS52G, ILE270F, ILE270G, ILE58F, ILE58G, ILE88F, ILE88G, LEU178F, LEU178G, LEU320F, LEU320G, LEU38F, LEU38G, LEU392F, LEU392G, LEU397F, LEU397G, LEU402F, LEU402G, LEU49F, LEU49G, LEU57F, LEU57G, LEU72F, LEU72G, MET287F, MET287G, MET43F, MET43G, MET85F, MET85G, PHE267F, PHE267G, PRO179F, PRO179G, PRO243F, PRO243G, PRO288F, PRO288G, PRO317F, PRO317G, PRO393F, PRO393G, PRO55F, PRO55G, PRO82F, PRO82G, SER177F, SER177G, SER249F, SER249G, SER269F, SER269G, SER391F, SER391G, THR37F, THR37G, THR401F, THR401G, THR68F, THR68G, THR84F, THR84G, THR86F, THR86G, TRP281F, TRP281G, TRP403F, TRP403G, TRP405F, TRP405G, TRP69F, TRP69G, TRP78F, TRP78G, TYR161G, TYR387F, TYR387G, TYR48F, TYR48G, TYR71F, TYR71G, TYR73F, TYR73G, TYR77F, TYR77G, VAL20F, VAL20G, VAL242F, VAL242G, VAL266F, VAL266G, VAL394F, VAL394G, VAL45F, VAL45G, VAL53F, VAL53G, VAL54F, VAL54G, VAL83F, VAL83G
• F-H: ALA352H, ALA382H, ARG359F, ASP357F, ASP378H, GLU361F, GLU369F, GLU379H, GLU380H, GLY368F, HIS356F, LEU366F, LEU381H, LYS384H, SER370F, TYR385H