3PJA

crystal structure of human c3po complex

• Total interactions analyzed: 66
• Total true interactions: 31
• Strongest Interaction:
  • Chains: A-K
  • Int. Res.: 17
  • Norm. En. per Res.: -3.7434
• Hub Node: B(7)

All Interactions

Chains	Hydro. Bond Ener. (kJ/mol)	Elec. Ener. (kJ/mol)	VDW. Ener. (kJ/mol)	Tot. Stab. Ener. (kJ/mol)	#int. res.	# Short cont.	#Hydr. int.	#VDW pairs	#salt bridges	#Pot. fav. elec. int	#Pot. unfav. elec. int
A-B	-13.6586	-16.9959	-157.3	-187.9545	85	2	3	6975	2	32	38
A-C	-23.6739	-8.2764	-146.968	-178.9184	83	9	3	6231	1	33	34
A-D	0.0	0.0	-1.7789	-1.7789	17	0	0	132	0	6	7
A-E	-11.6304	36.6732	-412.473	-387.4303	159	22	24	18989	7	63	65
A-K	-7.4324	-31.4256	-24.7801	-63.6381	17	0	1	1003	2	4	4
B-C	0.0	0.0	-0.1806	-0.1806	5	0	0	52	0	2	3
B-D	-19.9118	50.9833	-388.135	-357.0635	160	24	22	18032	7	61	67
B-F	0.0	0.0	-9.3996	-9.3996	27	0	0	652	0	9	10
B-H	0.0	0.0	-9.9828	-9.9828	30	0	0	616	0	5	4
B-I	0.0	0.0	-31.0043	-31.0043	23	0	0	1546	0	6	5
B-J	0.0	-4.3483	-89.6454	-93.9937	45	0	3	3793	0	14	11
B-K	-40.9357	-51.8063	-201.244	-293.9859	96	13	3	8394	4	17	25
C-E	0.0	-8.3	-12.3963	-20.6963	26	0	0	776	1	11	11
C-H	0.0	0.0	-38.5538	-38.5538	23	3	0	1754	0	6	5
C-K	-49.5473	-53.7291	-243.537	-346.8134	100	12	3	10421	7	31	34
C-L	-4.4165	25.8606	-410.96	-389.516	149	32	17	17954	6	49	53
D-E	-18.9462	-15.4481	-142.998	-177.3922	83	11	3	6790	2	32	37
D-F	-30.188	-7.9059	-162.194	-200.2879	88	11	3	6574	2	33	35
D-L	-3.6437	-28.2656	-25.018	-56.9273	18	0	1	1011	2	5	4
E-F	0.0	0.0	-0.4036	-0.4036	6	0	0	92	0	3	3
E-L	-40.1726	-40.0301	-209.831	-290.0337	90	13	3	9201	3	18	25
F-K	-23.4938	27.8805	-377.939	-373.5522	147	26	17	16965	6	49	53
F-L	-44.2198	-49.2214	-274.274	-367.7151	105	13	5	11209	8	32	36
G-H	-19.6579	-18.6391	-159.341	-197.638	82	8	3	7142	2	32	38
G-I	-34.9051	1.7798	-144.682	-177.8073	85	11	3	6506	1	28	32
G-J	-9.943	-35.8315	-24.5201	-70.2946	19	2	0	1092	2	5	4
H-I	0.0	0.0	-0.1435	-0.1435	6	0	0	48	0	2	3
H-J	-23.8459	-42.7386	-184.3	-250.8845	91	7	3	8101	2	17	24
H-K	-4.896	-3.7857	-90.4658	-99.1475	47	3	3	3823	0	13	11
I-J	-46.5493	-47.0148	-261.554	-355.1181	104	15	5	11091	6	31	34
K-L	-39.4373	-76.4118	-67.8153	-183.6644	64	4	0	2964	8	47	39

Interface residues

• A-B: ALA148A, ALA161A, ALA35A, ARG153A, ARG182B, ARG192B, ARG194A, ARG215A, ARG215B, ARG25A, ARG36A, ARG97A, ASN157A, ASN175B, ASN185B, ASN218B, ASP178B, ASP196B, ASP201A, ASP211A, ASP211B, GLN29A, GLN33A, GLN43A, GLU150A, GLU206B, GLU207A, GLU207B, GLU32A, GLU37A, GLY162A, GLY216A, GLY216B, GLY44A, HIS46A, ILE146A, ILE174B, ILE214A, ILE214B, ILE38A, LEU101A, LEU151A, LEU154A, LEU168B, LEU183B, LEU184B, LEU186B, LEU212A, LEU212B, LEU39A, LEU41A, LYS187B, LYS199B, LYS203B, LYS204A, LYS204B, PHE100A, PHE181B, PHE217A, PHE217B, PHE93A, PRO167A, SER149A, SER152A, SER155A, SER158A, SER171B, SER179B, SER213A, SER213B, THR160A, THR40A, TYR164A, TYR195B, TYR210A, TYR210B, VAL156A, VAL159A, VAL202B, VAL205A, VAL205B, VAL208A, VAL208B, VAL209A, VAL209B
• A-C: ALA161C, ALA35C, ARG153C, ARG182A, ARG192A, ARG194C, ARG215A, ARG215C, ARG25C, ARG36C, ARG97C, ASN157C, ASN175A, ASN185A, ASN218A, ASP178A, ASP196A, ASP201C, ASP211A, ASP211C, GLN29C, GLN33C, GLN43C, GLU150C, GLU206A, GLU207A, GLU207C, GLU32C, GLU37C, GLY162C, GLY216A, HIS46C, ILE174A, ILE214A, ILE214C, ILE38C, LEU101C, LEU154C, LEU168A, LEU183A, LEU184A, LEU186A, LEU198A, LEU212A, LEU212C, LEU39C, LEU41C, LEU42C, LYS187A, LYS199A, LYS203A, LYS203C, LYS204C, PHE100C, PHE181A, PHE217A, PHE93C, PRO167C, SER149C, SER152C, SER155C, SER158C, SER171A, SER179A, SER213A, SER30C, THR160C, THR40C, TYR164C, TYR195A, TYR200A, TYR200C, TYR210A, TYR210C, VAL156C, VAL159C, VAL202A, VAL205A, VAL208A, VAL208C, VAL209A, VAL209C, VAL28C
• A-D: ARG21D, ARG25A, ARG25D, ARG36A, ARG36D, GLN11A, GLN11D, GLN18A, GLN18D, GLN29A, GLN29D, GLN33A, GLN33D, GLU22A, GLU22D, LYS26A, LYS26D
• A-E: ALA118A, ALA148E, ALA15A, ALA15E, ALA16A, ALA16E, ALA81A, ALA81E, ARG116A, ARG116E, ARG129A, ARG129E, ARG182A, ARG182E, ARG192A, ARG192E, ARG21A, ARG21E, ARG25E, ARG86A, ARG86E, ARG92A, ARG92E, ASN175A, ASN175E, ASN185A, ASN185E, ASN188A, ASN188E, ASP128A, ASP128E, ASP136A, ASP136E, ASP139A, ASP139E, ASP178A, ASP178E, ASP189A, ASP189E, ASP19A, GLN11A, GLN11E, GLN18A, GLN18E, GLN83A, GLN83E, GLU111A, GLU111E, GLU117A, GLU117E, GLU130A, GLU130E, GLU138A, GLU138E, GLU176A, GLU176E, GLU17A, GLU17E, GLU22A, GLU22E, GLU5A, GLU5E, GLU82A, GLU82E, GLU9A, GLU9E, GLY12A, GLY12E, GLY132A, GLY180A, GLY180E, HIS134A, HIS134E, HIS88A, HIS88E, HIS90E, ILE174A, ILE174E, ILE6A, ILE6E, LEU10A, LEU10E, LEU113A, LEU113E, LEU135A, LEU135E, LEU141A, LEU141E, LEU145A, LEU145E, LEU14A, LEU14E, LEU177A, LEU177E, LEU183A, LEU183E, LEU184A, LEU184E, LEU186A, LEU186E, LEU191A, LEU191E, LEU198A, LEU198E, LYS131A, LYS131E, LYS187A, LYS187E, MET1E, PHE133A, PHE13A, PHE13E, PHE173A, PHE173E, PHE181A, PHE181E, PHE79A, PHE7A, PHE7E, PHE87A, PHE87E, PRO80A, PRO80E, SER179A, SER179E, SER2A, SER2E, SER4A, SER4E, THR112A, THR112E, THR115A, THR115E, THR172A, THR172E, TRP91A, TRP91E, TYR107A, TYR107E, TYR140A, TYR140E, TYR195A, TYR195E, TYR84A, TYR84E, TYR85A, TYR85E, VAL106A, VAL114A, VAL114E, VAL119A, VAL137A, VAL137E, VAL144A, VAL144E, VAL3A, VAL3E, VAL8A, VAL8E
• A-K: ARG215A, ARG263K, ASP211A, GLU207A, GLU266K, GLY216A, HIS270K, ILE214A, LEU212A, LEU272K, LYS269K, MET271K, PHE217A, PRO268K, SER213A, TYR210A, VAL262K
• B-C: ARG215B, ARG215C, ASP211C, ILE214B, TYR210C
• B-D: ALA118B, ALA118D, ALA15B, ALA15D, ALA16B, ALA16D, ALA81B, ALA81D, ARG116B, ARG116D, ARG129B, ARG129D, ARG182B, ARG182D, ARG192D, ARG21B, ARG21D, ARG25B, ARG25D, ARG86B, ARG86D, ARG92B, ARG92D, ASN175B, ASN175D, ASN185B, ASN185D, ASN188B, ASN188D, ASP128B, ASP128D, ASP136B, ASP136D, ASP139B, ASP139D, ASP178B, ASP178D, ASP189D, ASP19B, ASP19D, GLN11B, GLN11D, GLN18B, GLN18D, GLN83B, GLN83D, GLU111B, GLU111D, GLU117B, GLU117D, GLU130B, GLU130D, GLU138B, GLU138D, GLU176B, GLU176D, GLU17B, GLU17D, GLU22B, GLU22D, GLU5B, GLU5D, GLU82B, GLU82D, GLU9B, GLU9D, GLY12B, GLY12D, GLY132B, GLY132D, GLY180B, GLY180D, HIS134B, HIS134D, HIS88B, HIS88D, HIS90B, ILE174B, ILE174D, ILE6B, ILE6D, LEU10B, LEU10D, LEU113B, LEU113D, LEU135B, LEU135D, LEU141B, LEU141D, LEU145B, LEU145D, LEU14B, LEU14D, LEU177B, LEU177D, LEU183B, LEU183D, LEU184B, LEU184D, LEU186B, LEU186D, LEU191B, LEU191D, LEU198B, LEU198D, LYS131B, LYS131D, LYS187B, LYS187D, PHE133D, PHE13B, PHE13D, PHE173B, PHE173D, PHE181B, PHE181D, PHE79D, PHE7B, PHE7D, PHE87B, PHE87D, PRO80B, PRO80D, SER179B, SER179D, SER2B, SER2D, SER4B, SER4D, THR112B, THR112D, THR115B, THR115D, THR172B, THR172D, TRP91B, TRP91D, TYR107B, TYR107D, TYR140B, TYR140D, TYR195B, TYR195D, TYR84B, TYR84D, TYR85B, TYR85D, VAL106D, VAL114B, VAL114D, VAL119B, VAL119D, VAL137B, VAL137D, VAL144B, VAL144D, VAL3B, VAL3D, VAL8B, VAL8D
• B-F: ALA15B, ALA15F, ARG21B, ARG25B, ARG25F, ARG36B, ARG36F, ASP19F, GLN11B, GLN11F, GLN18B, GLN18F, GLN29B, GLN29F, GLN33B, GLN33F, GLN43B, GLU22B, GLU22F, GLU32B, GLU37B, LYS26B, LYS26F, SER4F, THR40B, VAL3F, VAL8F
• B-H: ALA161B, ALA161H, ALA49B, ALA49H, ARG166H, ASP163B, ASP163H, GLN52B, GLN52H, GLY162B, GLY162H, GLY216B, GLY48B, GLY48H, GLY50B, GLY50H, HIS169B, HIS169H, PHE217B, PHE217H, SER158B, SER158H, SER165B, SER165H, THR160B, THR160H, TYR164B, TYR164H, VAL159B, VAL159H
• B-I: ARG215I, ARG57B, ASN218I, ASP211I, ASP53B, CYS58B, GLN52B, GLU206I, GLU207I, GLU63B, GLY216I, ILE214I, ILE54B, LEU212I, LEU59B, LYS56B, LYS60B, PHE217I, PHE51B, PRO55B, SER213I, TYR210I, VAL209I
• B-J: ALA161B, ALA256J, ALA259J, ALA49B, ARG166B, ARG263J, ARG57B, ASP163B, ASP210J, ASP212J, ASP53B, CYS257J, CYS58B, GLN47B, GLN52B, GLU109B, GLU111B, GLU266J, GLY162B, GLY209J, GLY264J, GLY48B, GLY50B, HIS169B, ILE211J, ILE267J, ILE54B, LEU108B, LEU260J, LEU59B, LYS261J, LYS269J, LYS56B, MET271J, PHE215J, PHE51B, PRO214J, PRO268J, PRO55B, SER265J, THR110B, TYR107B, VAL206J, VAL262J, VAL45B
• B-K: ALA161B, ALA251K, ALA256K, ALA259K, ALA35B, ALA49B, ARG153B, ARG194B, ARG215B, ARG222K, ARG263K, ARG36B, ARG97B, ASN157B, ASN233K, ASN255K, ASP163B, ASP201B, ASP211B, ASP226K, CYS257K, GLN219K, GLN223K, GLN248K, GLN29B, GLN33B, GLN43B, GLN47B, GLU150B, GLU206B, GLU207B, GLU216K, GLU254K, GLU266K, GLU32B, GLU37B, GLY162B, GLY216B, GLY227K, GLY232K, GLY235K, GLY264K, GLY44B, GLY48B, HIS46B, ILE146B, ILE214B, ILE231K, ILE267K, LEU154B, LEU212B, LEU221K, LEU243K, LEU250K, LEU260K, LEU39B, LEU42B, LYS204B, LYS247K, LYS252K, LYS261K, LYS269K, PHE215K, PHE217B, PHE220K, PHE228K, PHE230K, PHE93B, PRO167B, PRO268K, SER149B, SER152B, SER155B, SER158B, SER218K, SER229K, SER265K, THR160B, THR234K, THR40B, TYR164B, TYR200B, TYR210B, TYR225K, TYR258K, VAL156B, VAL159B, VAL205B, VAL208B, VAL209B, VAL217K, VAL224K, VAL253K, VAL262K, VAL45B, VAL94B
• C-E: ALA15C, ALA15E, ARG21E, ARG25C, ARG25E, ARG36C, ARG36E, ASP19C, GLN11C, GLN11E, GLN18C, GLN18E, GLN29C, GLN29E, GLN33C, GLN33E, GLU22C, GLU22E, GLU32E, GLU37C, LEU14C, LYS26C, LYS26E, SER4C, THR40E, VAL8C
• C-H: ARG215C, ARG57H, ASN218C, ASP211C, ASP53H, CYS58H, GLN52H, GLU206C, GLU207C, GLU63H, GLY216C, ILE214C, ILE54H, LEU212C, LEU59H, LYS56H, LYS60H, PHE217C, PHE51H, PRO55H, SER213C, TYR210C, VAL209C
• C-K: ALA256K, ALA259K, ARG182C, ARG192C, ARG200K, ARG215C, ARG263K, ARG61K, ARG69K, ARG76K, ASN175C, ASN185C, ASN188C, ASN204K, ASN208K, ASN218C, ASN255K, ASP178C, ASP189C, ASP196C, ASP201C, ASP210K, ASP211C, CYS202K, CYS257K, GLU126K, GLU129K, GLU197K, GLU206C, GLU207C, GLU266K, GLY162C, GLY180C, GLY196K, GLY197C, GLY207K, GLY209K, GLY216C, GLY264K, HIS270K, HIS75K, ILE203K, ILE211K, ILE214C, ILE267K, ILE71K, ILE77K, ILE86K, LEU183C, LEU184C, LEU186C, LEU198C, LEU212C, LEU260K, LEU272K, LEU73K, LEU74K, LYS187C, LYS193C, LYS199C, LYS203C, LYS204C, LYS219C, LYS252K, LYS269K, LYS68K, LYS93K, MET199K, MET201K, MET271K, PHE181C, PHE217C, PHE72K, PRO167C, PRO214K, PRO268K, SER179C, SER205K, SER213C, SER249K, SER265K, SER79K, THR64K, THR70K, THR78K, TYR164C, TYR195C, TYR200C, TYR210C, TYR258K, VAL156C, VAL159C, VAL202C, VAL205C, VAL206K, VAL208C, VAL209C, VAL253K, VAL262K, VAL65K
• C-L: ALA15C, ALA16C, ALA192L, ALA38L, ALA81C, ARG116C, ARG118L, ARG140L, ARG181L, ARG182C, ARG21C, ARG222L, ARG49L, ARG86C, ARG92C, ASN175C, ASN185C, ASN188C, ASN233L, ASP112L, ASP128C, ASP136C, ASP139C, ASP146L, ASP178C, ASP186L, ASP189C, ASP19C, ASP226L, ASP47L, ASP51L, GLN115L, GLN11C, GLN18C, GLN219L, GLN223L, GLN43L, GLN44L, GLN83C, GLU111L, GLU117C, GLU138C, GLU147L, GLU176C, GLU17C, GLU45L, GLU54L, GLU5C, GLU82C, GLU89C, GLU9C, GLY12C, GLY132C, GLY180C, GLY227L, GLY232L, GLY235L, HIS114L, HIS117L, HIS134C, HIS135L, HIS50L, HIS88C, ILE143L, ILE148L, ILE174C, ILE231L, ILE6C, LEU10C, LEU113C, LEU135C, LEU141C, LEU142L, LEU145C, LEU14C, LEU177C, LEU183C, LEU184C, LEU186C, LEU188L, LEU189L, LEU191C, LEU194L, LEU198C, LEU221L, LEU246L, LEU37L, LEU46L, LYS131C, LYS187C, LYS40L, MET113L, MET145L, MET1C, MET36L, PHE116L, PHE136L, PHE13C, PHE173C, PHE181C, PHE220L, PHE228L, PHE230L, PHE39L, PHE42L, PHE7C, PHE87C, PRO184L, PRO236L, PRO34L, SER132L, SER141L, SER144L, SER179C, SER229L, SER2C, SER31L, SER32L, SER33L, SER41L, SER4C, THR112C, THR115C, THR121L, THR139L, THR172C, THR183L, THR195L, THR234L, TYR140C, TYR187L, TYR195C, TYR225L, TYR237L, TYR53L, TYR84C, TYR85C, VAL114C, VAL137C, VAL144C, VAL182L, VAL185L, VAL191L, VAL224L, VAL239L, VAL35L, VAL3C, VAL57L, VAL8C
• D-E: ALA148D, ALA161D, ALA35D, ARG153D, ARG182E, ARG192E, ARG194D, ARG215D, ARG215E, ARG25D, ARG36D, ARG97D, ASN157D, ASN175E, ASN185E, ASN218E, ASP178E, ASP196E, ASP201D, ASP211D, ASP211E, GLN29D, GLN33D, GLN43D, GLU150D, GLU206E, GLU207D, GLU207E, GLU32D, GLU37D, GLY162D, GLY216E, GLY44D, HIS46D, ILE146D, ILE174E, ILE214D, ILE214E, ILE38D, LEU101D, LEU151D, LEU154D, LEU168E, LEU183E, LEU184E, LEU186E, LEU212D, LEU212E, LEU39D, LEU41D, LEU42D, LYS187E, LYS199E, LYS203E, LYS204D, LYS204E, PHE181E, PHE217D, PHE93D, PRO167D, SER149D, SER152D, SER155D, SER158D, SER171E, SER179E, SER213D, SER213E, THR160D, THR40D, TYR164D, TYR195E, TYR200E, TYR210D, TYR210E, VAL156D, VAL159D, VAL202E, VAL205E, VAL208D, VAL208E, VAL209D, VAL209E
• D-F: ALA161F, ALA35F, ARG153F, ARG182D, ARG192D, ARG194F, ARG215D, ARG215F, ARG25F, ARG36F, ARG97F, ASN157F, ASN175D, ASN185D, ASN218D, ASP178D, ASP196D, ASP201F, ASP211D, ASP211F, GLN29F, GLN33F, GLN43F, GLU150F, GLU206D, GLU206F, GLU207D, GLU207F, GLU32F, GLU37F, GLY162F, GLY216D, HIS46F, ILE174D, ILE214D, ILE214F, ILE38F, LEU101F, LEU154F, LEU168D, LEU183D, LEU184D, LEU186D, LEU198D, LEU212D, LEU212F, LEU39F, LEU41F, LEU42F, LYS187D, LYS199D, LYS203D, LYS203F, LYS204D, LYS204F, PHE100F, PHE181D, PHE217D, PHE93F, PRO167F, SER149F, SER152F, SER155F, SER158F, SER171D, SER179D, SER213D, SER30F, THR160F, THR172D, THR40F, TYR164F, TYR195D, TYR200D, TYR200F, TYR210D, TYR210F, VAL156F, VAL159F, VAL202D, VAL205D, VAL205F, VAL208D, VAL208F, VAL209D, VAL209F, VAL28F, VAL45F
• D-L: ARG215D, ARG263L, ASP211D, GLU207D, GLU266L, GLY216D, HIS270L, ILE214D, ILE267L, LEU212D, LEU272L, LYS269L, MET271L, PHE217D, PRO268L, SER213D, TYR210D, VAL262L
• E-F: ARG215E, ARG215F, ASP211F, GLU207F, ILE214E, TYR210F
• E-L: ALA161E, ALA251L, ALA256L, ALA259L, ALA35E, ARG153E, ARG194E, ARG215E, ARG222L, ARG263L, ARG36E, ARG97E, ASN157E, ASN233L, ASN255L, ASP163E, ASP211E, ASP226L, CYS257L, GLN219L, GLN223L, GLN29E, GLN33E, GLN43E, GLN47E, GLU150E, GLU207E, GLU254L, GLU266L, GLU32E, GLU37E, GLY162E, GLY216E, GLY227L, GLY232L, GLY235L, GLY264L, GLY44E, GLY48E, HIS46E, ILE146E, ILE214E, ILE231L, ILE267L, LEU154E, LEU212E, LEU221L, LEU243L, LEU250L, LEU260L, LEU39E, LEU41E, LEU42E, LYS204E, LYS247L, LYS252L, LYS261L, LYS269L, PHE100E, PHE215L, PHE217E, PHE228L, PHE230L, PHE93E, PRO167E, PRO268L, SER149E, SER152E, SER155E, SER158E, SER218L, SER229L, SER265L, THR160E, THR234L, THR40E, TYR164E, TYR210E, TYR225L, TYR258L, VAL156E, VAL159E, VAL205E, VAL208E, VAL209E, VAL253L, VAL262L, VAL28E, VAL45E, VAL94E
• F-K: ALA119K, ALA15F, ALA16F, ALA192K, ALA38K, ALA81F, ARG116F, ARG118K, ARG140K, ARG181K, ARG182F, ARG21F, ARG222K, ARG49K, ARG55K, ARG86F, ARG92F, ASN175F, ASN185F, ASN188F, ASN233K, ASP112K, ASP128F, ASP136F, ASP139F, ASP146K, ASP178F, ASP186K, ASP189F, ASP226K, ASP47K, ASP51K, GLN115K, GLN11F, GLN18F, GLN219K, GLN223K, GLN43K, GLN44K, GLN83F, GLU111K, GLU117F, GLU138F, GLU147K, GLU176F, GLU17F, GLU45K, GLU54K, GLU5F, GLU82F, GLU89F, GLU9F, GLY12F, GLY132F, GLY180F, GLY227K, GLY232K, GLY235K, HIS114K, HIS117K, HIS134F, HIS135K, HIS50K, HIS88F, ILE143K, ILE148K, ILE231K, ILE6F, LEU10F, LEU113F, LEU135F, LEU141F, LEU142K, LEU145F, LEU14F, LEU177F, LEU183F, LEU184F, LEU186F, LEU188K, LEU189K, LEU191F, LEU194K, LEU198F, LEU221K, LEU243K, LEU246K, LEU37K, LEU46K, LYS131F, LYS187F, LYS40K, LYS52K, MET113K, MET145K, MET1F, MET36K, PHE116K, PHE136K, PHE13F, PHE173F, PHE181F, PHE220K, PHE228K, PHE230K, PHE39K, PHE42K, PHE7F, PHE87F, PRO184K, PRO236K, PRO34K, SER141K, SER144K, SER179F, SER229K, SER2F, SER31K, SER32K, SER33K, SER41K, SER4F, THR112F, THR115F, THR121K, THR183K, THR195K, THR234K, TYR140F, TYR187K, TYR195F, TYR225K, TYR53K, TYR84F, TYR85F, VAL114F, VAL137F, VAL144F, VAL182K, VAL185K, VAL191K, VAL224K, VAL239K, VAL35K, VAL3F, VAL57K, VAL8F
• F-L: ALA256L, ALA259L, ALA273L, ALA80L, ARG182F, ARG192F, ARG200L, ARG215F, ARG263L, ARG61L, ARG69L, ARG76L, ASN175F, ASN185F, ASN188F, ASN204L, ASN208L, ASN218F, ASN255L, ASP178F, ASP189F, ASP196F, ASP201F, ASP210L, ASP211F, CYS202L, CYS257L, GLN248L, GLU126L, GLU129L, GLU197L, GLU206F, GLU207F, GLU266L, GLY162F, GLY180F, GLY196L, GLY197F, GLY207L, GLY209L, GLY216F, GLY264L, HIS270L, HIS75L, ILE174F, ILE203L, ILE211L, ILE214F, ILE267L, ILE71L, ILE77L, ILE86L, LEU183F, LEU184F, LEU186F, LEU198F, LEU212F, LEU260L, LEU272L, LEU73L, LEU74L, LYS187F, LYS193F, LYS199F, LYS203F, LYS204F, LYS219F, LYS252L, LYS269L, LYS68L, LYS93L, MET199L, MET201L, MET271L, PHE133L, PHE181F, PHE217F, PHE72L, PRO214L, PRO268L, SER171F, SER179F, SER205L, SER213F, SER249L, SER265L, SER79L, THR64L, THR70L, THR78L, TYR164F, TYR195F, TYR200F, TYR210F, TYR258L, VAL156F, VAL159F, VAL202F, VAL205F, VAL206L, VAL208F, VAL209F, VAL253L, VAL262L, VAL65L
• G-H: ALA148G, ALA161G, ALA35G, ARG153G, ARG182H, ARG192H, ARG194G, ARG215G, ARG215H, ARG25G, ARG36G, ARG97G, ASN157G, ASN175H, ASN185H, ASP178H, ASP196H, ASP201G, ASP211G, ASP211H, GLN29G, GLN33G, GLN43G, GLU150G, GLU206H, GLU207G, GLU207H, GLU32G, GLU37G, GLY162G, GLY216H, GLY44G, HIS46G, ILE146G, ILE174H, ILE214G, ILE214H, ILE38G, LEU101G, LEU151G, LEU154G, LEU168H, LEU183H, LEU184H, LEU186H, LEU212G, LEU212H, LEU39G, LEU41G, LEU42G, LYS187H, LYS199H, LYS203H, LYS204G, LYS204H, PHE181H, PHE217G, PHE217H, PHE93G, PRO167G, SER149G, SER152G, SER155G, SER158G, SER171H, SER179H, SER213G, SER213H, THR160G, THR40G, TYR164G, TYR195H, TYR210G, TYR210H, VAL156G, VAL159G, VAL202H, VAL205H, VAL208G, VAL208H, VAL209G, VAL209H
• G-I: ALA161I, ALA35I, ARG153I, ARG182G, ARG192G, ARG194I, ARG215G, ARG215I, ARG25I, ARG36I, ARG97I, ASN157I, ASN175G, ASN185G, ASN218G, ASP178G, ASP196G, ASP201I, ASP211G, ASP211I, GLN29I, GLN33I, GLN43I, GLU150I, GLU206G, GLU206I, GLU207G, GLU207I, GLU32I, GLU37I, GLY162I, GLY180G, GLY216G, ILE174G, ILE214G, ILE214I, LEU101I, LEU154I, LEU168G, LEU183G, LEU184G, LEU186G, LEU198G, LEU212G, LEU212I, LEU39I, LEU41I, LYS187G, LYS199G, LYS203G, LYS204G, LYS204I, PHE100I, PHE181G, PHE217G, PHE217I, PHE93I, PRO167I, SER149I, SER152I, SER155I, SER158I, SER171G, SER179G, SER213G, SER213I, SER30I, THR160I, THR40I, TYR164I, TYR195G, TYR200G, TYR200I, TYR210G, TYR210I, VAL156I, VAL159I, VAL202G, VAL205G, VAL205I, VAL208G, VAL208I, VAL209G, VAL209I, VAL28I
• G-J: ARG215G, ARG263J, ASN218G, ASP211G, GLU207G, GLU266J, GLY216G, HIS270J, ILE214G, ILE267J, LEU212G, LEU272J, LYS269J, MET271J, PHE217G, PRO268J, SER213G, TYR210G, VAL262J
• H-I: ARG215H, ARG215I, ASP211I, ILE214H, ILE214I, TYR210I
• H-J: ALA161H, ALA251J, ALA256J, ALA259J, ALA35H, ALA49H, ARG153H, ARG194H, ARG215H, ARG222J, ARG263J, ARG36H, ARG97H, ASN157H, ASN233J, ASN255J, ASP163H, ASP211H, ASP226J, CYS257J, GLN219J, GLN223J, GLN248J, GLN29H, GLN33H, GLN43H, GLN47H, GLU150H, GLU207H, GLU254J, GLU266J, GLU32H, GLU37H, GLY162H, GLY216H, GLY227J, GLY232J, GLY235J, GLY264J, GLY44H, GLY48H, HIS46H, ILE146H, ILE214H, ILE231J, ILE267J, LEU154H, LEU212H, LEU221J, LEU243J, LEU250J, LEU260J, LEU39H, LEU42H, LYS204H, LYS247J, LYS252J, LYS261J, LYS269J, PHE100H, PHE215J, PHE217H, PHE228J, PHE230J, PHE93H, PRO167H, PRO268J, SER149H, SER152H, SER155H, SER158H, SER218J, SER229J, SER265J, THR160H, THR234J, THR40H, TYR164H, TYR200H, TYR210H, TYR225J, TYR258J, VAL156H, VAL159H, VAL208H, VAL209H, VAL253J, VAL262J, VAL28H, VAL45H, VAL94H
• H-K: ALA161H, ALA256K, ALA259K, ALA49H, ARG166H, ARG263K, ARG57H, ASP163H, ASP210K, ASP212K, ASP53H, CYS257K, CYS58H, GLN47H, GLN52H, GLU109H, GLU111H, GLU266K, GLY162H, GLY209K, GLY264K, GLY48H, GLY50H, HIS169H, ILE211K, ILE267K, ILE54H, LEU108H, LEU260K, LEU59H, LYS261K, LYS269K, LYS56H, LYS60H, MET271K, PHE215K, PHE51H, PRO214K, PRO268K, PRO55H, SER158H, SER265K, THR110H, TYR107H, VAL206K, VAL262K, VAL45H
• I-J: ALA256J, ALA259J, ALA273J, ARG182I, ARG192I, ARG200J, ARG215I, ARG263J, ARG61J, ARG69J, ARG76J, ASN175I, ASN185I, ASN188I, ASN204J, ASN208J, ASN218I, ASN255J, ASP178I, ASP189I, ASP196I, ASP201I, ASP210J, ASP211I, ASP274J, CYS202J, CYS257J, GLN248J, GLU126J, GLU129J, GLU197J, GLU206I, GLU207I, GLU266J, GLY162I, GLY180I, GLY196J, GLY197I, GLY207J, GLY209J, GLY216I, GLY264J, HIS270J, HIS75J, ILE203J, ILE211J, ILE214I, ILE267J, ILE71J, ILE77J, LEU183I, LEU184I, LEU186I, LEU198I, LEU212I, LEU260J, LEU272J, LEU73J, LEU74J, LYS187I, LYS193I, LYS199I, LYS203I, LYS204I, LYS219I, LYS252J, LYS269J, LYS68J, LYS93J, MET199J, MET201J, MET271J, PHE181I, PHE217I, PHE72J, PRO167I, PRO214J, PRO268J, SER171I, SER179I, SER205J, SER213I, SER249J, SER265J, SER79J, THR160I, THR64J, THR70J, THR78J, TYR164I, TYR195I, TYR200I, TYR210I, TYR258J, VAL156I, VAL159I, VAL202I, VAL205I, VAL206J, VAL208I, VAL209I, VAL253J, VAL262J, VAL65J
• K-L: ALA48K, ALA48L, ARG49K, ARG49L, ARG55K, ARG55L, ARG61K, ARG61L, ARG69K, ARG69L, ARG76K, ARG76L, ASP47K, ASP47L, ASP51K, ASP51L, ASP62K, ASP62L, ASP82K, GLN43K, GLN43L, GLN44K, GLN44L, GLU54K, GLU54L, GLU89K, GLU89L, HIS50K, HIS50L, ILE63K, ILE63L, LEU46K, LEU46L, LEU59K, LEU59L, LEU73K, LEU73L, LYS100K, LYS100L, LYS40K, LYS40L, LYS52K, LYS52L, LYS58K, LYS58L, LYS93K, LYS93L, MET36K, MET36L, PHE39K, PHE39L, PHE72K, PHE72L, SER31L, SER60K, SER60L, THR64K, THR64L, TYR53K, TYR53L, VAL57K, VAL57L, VAL65K, VAL65L